A Post-market Study to Assess the STENTYS Self-exPanding COronary Stent In AcuTe myocardial InfarctiON in Real Life APPOSITION III

Size: px
Start display at page:

Download "A Post-market Study to Assess the STENTYS Self-exPanding COronary Stent In AcuTe myocardial InfarctiON in Real Life APPOSITION III"

Transcription

1 A Post-market Study to Assess the STENTYS Self-exPanding COronary Stent In AcuTe myocardial InfarctiON in Real Life APPOSITION III Gilles Montalescot, MD, PhD Pitié-Salpêtrière Hospital, Paris, France On behalf of the APPOSITION III investigators

2 The Sizing Dilemma in STEMI Malapposition / Underexpansion Overdilation Stent thrombosis Restenosis Dissection/ Perforation No reflow

3 Malapposition in a STEMI patient Balloon-expandable stent STENTYS Self-Apposing Stent Malapposition at 3 days Good apposition at 3 days 3 day OCT pictures from patients enrolled in the STENTYS Apposition II Trial

4 STENTYS Self-Apposing Stent Self-expanding Nitinol stent deployed by retracting a sheath (no balloon) Bare or Paclitaxel-eluting with Polysulfone biostable polymer 6 French, single-wire, rapid exchange Disconnecting struts for side-branch access Disconnectors along the stent Disconnectable interconnector Disconnection

5 STEMI Clinical Study Program Reference vessel showed a 19% lumen area increase distal to the occlusion at three days in STEMI patients. (APPOSITION I) OCT follow-up at three days showed all STENTYS stents perfectly apposed, while 28% of balloon-expandable stents were malapposed. (APPOSITION II) The STENTYS nitinol platform therefore accommodates early changes in AMI vessel anatomy that are caused by thrombus dissolution and resolution of vessel spasm. The APPOSITION III study evaluates the long-term clinical benefit of the STENTYS BMS and DES (P) stents in STEMI patients in a real-life setting. APPOSITION I: G. Amoroso et al. EuroIntervention 2011;7: APPOSITION II: J Am Coll Cardiol Intv. 2012;5(12):

6 APPOSITION III Study DESIGN Prospective, non-randomized, single-arm, multi-centre study of the STENTYS coronary stent OBJECTIVE Evaluate safety and performance of the STENTYS stent in routine clinical practice in 1000 STEMI patients STUDY DEVICE PES and BMS STENTYS stents were available (use at operator s discretion) PRIMARY ENDPOINT MACE at 12 months: cardiac death, target-vessel re-mi, or clinicallydriven TLR SECONDARY ENDPOINTS Definite / probable stent thrombosis All-cause mortality, any MI, any TVR

7 Study organization Steering Committee G. Amoroso G. De Luca U. Limbruno M. Wiemer Project Management E. Versteven Independent Monitoring Genae Associates Clinical Event Committee P.F. Agostoni G.J. Laarman Data Analysis (AMC Amsterdam) M.J. Grundeken J.G.P. Tijssen

8 Inclusions: 51 Centers 14 Countries

9 Eligibility Criteria Inclusion criteria Patients with STEMI caused by a de novo lesion in a native coronary artery Reference vessel diameter between 2.5 and 4.5mm by visual estimate Exclusion criteria Unprotected left main coronary artery Cardiogenic shock Any vasculature lesions or characteristics preventing PCI, introduction of the STENTYS delivery system or placement of the STENTYS stent

10 Study population 1002 patients enrolled Not fulfilling inclusion criteria (n=24) No STEMI/not a de novo lesion (n=15) Left main (n=2) RVD < 2.5 or > 4.5 mm (n=2) No informed consent obtained (n=1) Cardiogenic shock (n=2) STENTYS was used as second (bail-out) stent (n=2) Stent placement unsuccessful (n=10) Stent did not pass the lesion (n=7) Stent could not be deployed (n=3) No follow-up available (n=3) Study population (n=965)

11 Patient Characteristics n=965 Age (mean) 60±12 Male gender 77% Diabetes mellitus 15% Hypertension 47% Hypercholesterolemia 42% Smoking (current) 56% Previous MI 5% Previous PCI 6% Median STB time (hrs:min) 3:30

12 Angiographic Characteristics n=965 Target vessel LAD/LCX/RCA (%) 37 / 14 / 49 Lesion B2/C (%) 68 Visible thrombus (%) 89 Tortuosity (moderate/severe) (%) 12 Calcification (%) 43 TIMI at baseline 0-1/2/3 (%) 70 / 17 / 13 Median lesion length (mm) 18 Median vessel diameter (mm) 3.5

13 Procedural Characteristics n=965 Preload P2Y 12 inhibitors (%) 81 GP IIb/IIIa inhibitors (%) 39 Thromboaspiration (%) 74 Pre-dilation performed (%) 54 Overlapping stents (%) 22 Post-dilation performed (%) 71 Median final balloon diameter (mm) 3.5 Median maximal pressure (atm) 14 Final TIMI post-procedure 0-1/2/3 (%) 1 / 4 / 95 BMS/DES (%) 74 / 26

14 Clinical outcomes at 1 year Event Patients Event rate* MACE % Cardiac death % Target vessel MI % Clinically driven TLR % Cardiac Death/target vessel MI % Death from any cause % Any MI % Any TVR % Definite/probable ST % Definite ST % Acute / Sub-Acute / Late 13 / 11 / / 1.2 / 0.3% Probable ST 6 0.6% Acute / Sub-Acute / Late 0 / 6 / 0 0 / 0.6 / 0% * Kaplan-Meier estimate at one year

15 Clinical outcomes over time MACE: 9.3% Cardiac death or TV-MI: 3.2% Cardiac death: 2.0%

16 STENTYS BMS / DES (P) subgroups Population Differences n=717 n=248 BMS DES P-value Age (mean) 59±12 62± Diabetes mellitus (%) < Hypertension (%) Hypercholesterolemia (%) Previous MI (%) Previous PCI (%) Bifurcation (sidebranch >2.25mm) DES patients had more complex baseline characteristics

17 STENTYS BMS / DES (P) subgroups Results at 1 year BMS DES P-value n=717 n=248 MACE 8.8% 10.7% NS Cardiac death 2.2% 1.7% NS Target-Vessel re-mi 1.3% 1.3% NS Clinically-indicated TLR 6.9% 9.1% NS Cardiac death/tv-mi 3.3% 2.9% NS Definite/probable ST 3.2% 4.1% NS Definite ST 2.5% 3.7% NS Kaplan-Meier estimates

18 MACE according to post-dilation

19 Landmark analysis of MACE according to post-dilation

20 Cardiac death/tv-mi and ST by post-dilation Cardiac death or TV-MI Definite ST Advantage of post-dilation is sustained at 1 year

21 No difference in 1-year MACE in the following sub-groups

22 Comparative Studies 7% 6% Death at 1 year 5% 4% 3.9% 3% 2% 2.0% 1% 0% Pooled analysis conducted by the ACTION Study Group (La Pitié-Salpêtrière Hospital, Paris) on the most recent studies representing 19,767 patients since 2006 Some studies report all death, others cardiac death. APPOSITION III reports cardiac death.

23 Conclusions The Self-Apposing STENTYS stents show good long-term clinical outcomes in a real-life STEMI population These results support the hypothesis that correct stent sizing and the elimination of malapposition after primary PCI lead to good long-term results Post-dilation significantly improves 30-day outcome with good sustained results in the long-term APPOSITION V the FDA-approved, randomized study (currently enrolling) will provide further evidence

LEADERS: 5-Year Follow-up

LEADERS: 5-Year Follow-up LEADERS: -Year Follow-up from a Prospective, Randomized Trial of Biolimus A9-eluting Stents with a Biodegradable Polymer vs. Sirolimus-eluting Stents with a Durable Polymer : Final Report of the LEADERS

More information

Cilostazol versus Clopidogrel after Coronary Stenting

Cilostazol versus Clopidogrel after Coronary Stenting Cilostazol versus Clopidogrel after Coronary Stenting Seong-Wook Park, MD, PhD, FACC Division of Cardiology, Asan Medical Center University of Ulsan College of Medicine Seoul, Korea AMC, 2004 Background

More information

Copenhagen University Hospital Rigshospitalet Aarhus University Hospital Skejby Denmark

Copenhagen University Hospital Rigshospitalet Aarhus University Hospital Skejby Denmark Long-term outcome after drug-eluting versus bare-metal stent implantation in patients with ST-elevation myocardial infarction 3 year follow-up of the randomised trial Peter Clemmensen, Henning Kelbæk,

More information

Majestic Trial 12 Month Results

Majestic Trial 12 Month Results Majestic Trial 12 Month Results S.Müller-Hülsbeck, MD, EBIR, FCIRSE, FICA ACADEMIC HOSPITALS Flensburg of Kiel University Ev.-Luth. Diakonissenanstalt zu Flensburg Knuthstraße 1, 24939 FLENSBURG Dept.

More information

Antonio Colombo MD on behalf of the SECURITY Investigators

Antonio Colombo MD on behalf of the SECURITY Investigators Second Generation Drug-Eluting Stents Implantation Followed by Six Versus Twelve-Month - Dual Antiplatelet Therapy - The SECURITY Randomized Clinical Trial Antonio Colombo MD on behalf of the SECURITY

More information

OPINION OPtical frequency domain imaging vs. INtravascular ultrasound in percutaneous coronary InterventiON

OPINION OPtical frequency domain imaging vs. INtravascular ultrasound in percutaneous coronary InterventiON OPINION OPtical frequency domain imaging vs. INtravascular ultrasound in percutaneous coronary InterventiON - Baseline preliminary results - Takashi Akasaka, MD, PhD, FESC Wakayama Medical University,

More information

Pantera Lux Device Description and Overview of Clinical Data

Pantera Lux Device Description and Overview of Clinical Data Pantera Lux Device Description and Overview of Clinical Data Ralph Tölg, MD Herzzentrum Segeberger Kliniken GmbH Bad Segeberg, Germany Disclosure Statement of Financial Interest Within the past 12 months,

More information

Duration of Dual Antiplatelet Therapy After Coronary Stenting

Duration of Dual Antiplatelet Therapy After Coronary Stenting Duration of Dual Antiplatelet Therapy After Coronary Stenting C. DEAN KATSAMAKIS, DO, FACC, FSCAI INTERVENTIONAL CARDIOLOGIST ADVOCATE LUTHERAN GENERAL HOSPITAL INTRODUCTION Coronary artery stents are

More information

EXAMINATION trial. Manel Sabaté Hospital Clínic, Barcelona (On behalf of the Examination Investigators)

EXAMINATION trial. Manel Sabaté Hospital Clínic, Barcelona (On behalf of the Examination Investigators) EXAMINATION trial Manel Sabaté Hospital Clínic, Barcelona (On behalf of the Examination Investigators) EXAMINATION trial Background and Rationale (I) Acute coronary syndromes repeatedly appear as independent

More information

The Pantera Lux Paclitaxel DEB Device Description and Clinical Studies. Christoph Hehrlein, University Clinic Freiburg i.br.

The Pantera Lux Paclitaxel DEB Device Description and Clinical Studies. Christoph Hehrlein, University Clinic Freiburg i.br. The Pantera Lux Paclitaxel DEB Device Description and Clinical Studies Christoph Hehrlein, University Clinic Freiburg i.br. Germany Disclosure Statement of Financial Interest Within the past 12 months,

More information

Intracoronary Stenting and. Robert A. Byrne, Julinda Mehilli, Salvatore Cassese, Franz-Josef Neumann, Susanne Pinieck, Tomohisa Tada,

Intracoronary Stenting and. Robert A. Byrne, Julinda Mehilli, Salvatore Cassese, Franz-Josef Neumann, Susanne Pinieck, Tomohisa Tada, Prospective, Randomized Trial of Paclitaxel-Eluting Balloon versus Paclitaxel-Eluting Stent versus Balloon Angioplasty for Treatment of Coronary Restenosis in Limus- Eluting Stents Intracoronary Stenting

More information

PIHRATE Trial. Polish-Italian-Hungarian Randomized ThrombEctomy Trial. Dariusz Dudek MD, PhD. On behalf PIHRATE investigators

PIHRATE Trial. Polish-Italian-Hungarian Randomized ThrombEctomy Trial. Dariusz Dudek MD, PhD. On behalf PIHRATE investigators Polish-Italian-Hungarian Randomized ThrombEctomy Trial PIHRATE Trial On behalf PIHRATE investigators Dariusz Dudek MD, PhD Institute of Cardiology, Krakow, Poland Impact of distal embolization Distal embolization

More information

MEDICAL POLICY No. 91580-R1 DRUG-ELUTING STENTS FOR ISCHEMIC HEART DISEASE

MEDICAL POLICY No. 91580-R1 DRUG-ELUTING STENTS FOR ISCHEMIC HEART DISEASE DRUG-ELUTING STENTS FOR ISCHEMIC HEART DISEASE Effective Date: October 1, 2015 Review Dates: 10/11, 10/12, 10/13, 8/14, 8/15 Date Of Origin: October 12, 2011 Status: Current Summary of Changes Clarifications:

More information

Investor Presentation

Investor Presentation Investor Presentation February 2015 General Disclaimer This presentation contains forward-looking statements about the Company s business and prospects. Such forward-looking statements are based on numerous

More information

OCT STEMI: OCT guidance during stent implantation

OCT STEMI: OCT guidance during stent implantation OCT STEMI: OCT guidance during stent implantation in primary PCI. A Randomized Multicenter study with 9-month optical coherence tomography follow-up Červinka P 1,2, Kala P 3, Jakl M 2,4, Kaňovský J 3,

More information

Clinical Programs. Medtronic Coronary Stent Systems. driver BMS

Clinical Programs. Medtronic Coronary Stent Systems. driver BMS Clinical Programs Medtronic Coronary Stent Systems Endeavor DES driver BMS July 2010 Contents Overview of Clinical Programs... 2 Drug-Eluting Stents ENDEAVOR I*... 4 ENDEAVOR II*... 6 ENDEAVOR II Continued

More information

Pooled RESOLUTE Clinical Program

Pooled RESOLUTE Clinical Program The Relationship Between Short and Long-term Antiplatelet Therapy Use and Stent Thrombosis Following Percutaneous Coronary Intervention With the Resolute Zotarolimus-eluting Stent Pooled RESOLUTE Clinical

More information

Ostial LAD: Single stent approach is the best. Antonio A. Pocoví, MD, FSCAI, MTSAC, Advisory Council Member, CACI

Ostial LAD: Single stent approach is the best. Antonio A. Pocoví, MD, FSCAI, MTSAC, Advisory Council Member, CACI Ostial LAD: Single stent approach is the best Antonio A. Pocoví, MD, FSCAI, MTSAC, Advisory Council Member, CACI Chair, Interventional Cardiology Sanatorio San Lucas Instituto Alexander Fleming Buenos

More information

Coronary Bifurcation Treatment: Update from the European Bifurcation Club. Remo Albiero, MD Ist. Clinico S. Rocco Brescia (Italy)

Coronary Bifurcation Treatment: Update from the European Bifurcation Club. Remo Albiero, MD Ist. Clinico S. Rocco Brescia (Italy) Coronary Bifurcation Treatment: Update from the European Bifurcation Club Remo Albiero, MD Ist. Clinico S. Rocco Brescia (Italy) Disclosure Statement of Financial Interest Within the past 12 months, I

More information

PRECOMBAT Trial. Seung-Whan Lee, MD, PhD On behalf of the PRECOMBAT Investigators

PRECOMBAT Trial. Seung-Whan Lee, MD, PhD On behalf of the PRECOMBAT Investigators Premier of Randomized Comparison of Bypass Surgery versus Angioplasty Using Sirolimus-Eluting Stent in Patients with Left Main Coronary Artery Disease PRECOMBAT Trial Seung-Whan Lee, MD, PhD On behalf

More information

The Role of Self-expanding Stents in Patients with Atypical Coronary Anatomy

The Role of Self-expanding Stents in Patients with Atypical Coronary Anatomy oronary The Role of Self-expanding Stents in Patients with Atypical oronary Anatomy Robert-Jan van Geuns, 1 Katherin Awad, 2 Alexander IJsselmuiden, 3 and Karel Koch 4 1. Erasmus Medical entre, Rotterdam,

More information

Drug-Eluting Balloons. Klaus Bonaventura Department of Cardiology and Angiology Heart Thorax Vascular Center, Klinikum Ernst von Bergmann, Potsdam

Drug-Eluting Balloons. Klaus Bonaventura Department of Cardiology and Angiology Heart Thorax Vascular Center, Klinikum Ernst von Bergmann, Potsdam Drug-Eluting Balloons Klaus Bonaventura Department of Cardiology and Angiology Heart Thorax Vascular Center, Klinikum Ernst von Bergmann, Potsdam Potential conflicts of interest Speaker s name: Klaus Bonaventura

More information

Early healing after treatment of coronary lesions by everolimus, or biolimus eluting bioresorbable polymer stents

Early healing after treatment of coronary lesions by everolimus, or biolimus eluting bioresorbable polymer stents Early healing after treatment of coronary lesions by everolimus, or biolimus eluting bioresorbable polymer stents One-month results of the study Ida Riise Balleby 1, Trine Krejberg Ørhøj 1, Christian Juhl

More information

The Minvasys Amazonia Pax & Nile Pax Polymer Free Paclitaxel Eluting Stent Program

The Minvasys Amazonia Pax & Nile Pax Polymer Free Paclitaxel Eluting Stent Program The Minvasys Amazonia Pax & Nile Pax Polymer Free Paclitaxel Eluting Stent Program Jean Fajadet, MD, FESC Clinique Pasteur - Toulouse - France Disclosure statement Nothing to disclose Dedicated Delivery

More information

University of Ulsan College of Medicine, Asan Medical Center on behalf of the REAL-LATE and the ZEST-LATE trial

University of Ulsan College of Medicine, Asan Medical Center on behalf of the REAL-LATE and the ZEST-LATE trial Duration of Dual Antiplatelet Therapy After Drug-Eluting Stent Implantation A Pooled Analysis of the REAL-LATE and the ZEST-LATE Trial Seung-Jung Park MD PhD Seung-Jung Park, MD, PhD, University of Ulsan

More information

Déjeuner/Repas Débat ABBOTT «Docteur, je veux un stent qui se dissout» ABSORB,la révolu@on oui, mais chez quel pa@ent? Les dernières données ABSORB

Déjeuner/Repas Débat ABBOTT «Docteur, je veux un stent qui se dissout» ABSORB,la révolu@on oui, mais chez quel pa@ent? Les dernières données ABSORB Déjeuner/Repas Débat ABBOTT «Docteur, je veux un stent qui se dissout» ABSORB,la révolu@on oui, mais chez quel pa@ent? Les dernières données ABSORB Didier Carrié CHU Toulouse APPAC 4 Juin 2014 Aucun conflit

More information

Clinical Results of Unprotected Left Main Coronary Stenting

Clinical Results of Unprotected Left Main Coronary Stenting Original Articles IMAJ VOL 11 MARCH 2009 Clinical Results of Unprotected Left Main Coronary Stenting Itsik Ben-Dor MD, Hana Vaknin-Assa MD, Eli Lev MD, David Brosh MD, Shmuel Fuchs MD, Abid Assali MD and

More information

Cardiovascular disease has become a dominant cause of

Cardiovascular disease has become a dominant cause of Abstract Immediate and Six-month Clinical Outcome of Percutaneous Coronary Intervention in a Tertiary Hospital in the Sultanate of Oman Panduranga Prashanth, Mohamed Mukhaini, Abdulla A. Riyami, Kadhim

More information

Steven J. Yakubov, MD FACC For the CoreValve US Clinical Investigators

Steven J. Yakubov, MD FACC For the CoreValve US Clinical Investigators Long-Term Outcomes Using a Self- Expanding Bioprosthesis in Patients With Severe Aortic Stenosis Deemed Extreme Risk for Surgery: Two-Year Results From the CoreValve US Pivotal Trial Steven J. Yakubov,

More information

06 Validation of risk prediction model

06 Validation of risk prediction model HA Territory-wide PCI Audit 2003-06 06 Validation of risk prediction model PCI Audit Working Group Central Committee (Cardiac Services) HA Convention 2007 Background Participants: All HA hospitals via

More information

Presenter: Marco Valgimigli, MD PhD, FESC Erasmus MC, Thoraxcenter Rotterdam The Netherlands

Presenter: Marco Valgimigli, MD PhD, FESC Erasmus MC, Thoraxcenter Rotterdam The Netherlands Comparing zotarolimus-eluting and bare-metal stent efficacy in selected high bleeding risk patients treated with a short dual antiplatelet therapy duration. A pre-specified analysis from the The Zotarolimuseluting

More information

Polymer-Based, Paclitaxel-Eluting TAXUS Liberté Stent in De Novo Lesions: The Pivotal TAXUS ATLAS Trial

Polymer-Based, Paclitaxel-Eluting TAXUS Liberté Stent in De Novo Lesions: The Pivotal TAXUS ATLAS Trial Polymer-Based, Paclitaxel-Eluting Stent in De Novo Lesions: The Pivotal TAXUS ATLAS Trial Mark A. Turco, John A. Ormiston, Jeffrey J. Popma, Lazar Mandinov, Charles D. O'Shaughnessy, Tift Mann, Thomas

More information

Do método diagnóstico ao terapêutico: a História da Hemodinâmica e da Cardiologia Intervencionista, em 15 minutos. Eulógio E Martinez

Do método diagnóstico ao terapêutico: a História da Hemodinâmica e da Cardiologia Intervencionista, em 15 minutos. Eulógio E Martinez Do método diagnóstico ao terapêutico: a História da Hemodinâmica e da Cardiologia Intervencionista, em 15 minutos Eulógio E Martinez IVUS vs luminologia Positivo Negativo estenose TCE oclusão CD sístole

More information

Editorial. Adult Cardiology - Meta-analysis

Editorial. Adult Cardiology - Meta-analysis Editorial Adult Cardiology - Meta-analysis Simple Versus Complex Bifurcation Stenting Strategies A Meta Analysis of Randomized Controlled Trials in the Drug Eluting Stent Era Ana Beatriz R. Medrano, MD

More information

BRIGHT Trial. Bivalirudin versus Heparin and Heparin plus Tirofiban in Patients with AMI Undergoing PCI. Thirty-Day and One-Year Outcomes of the

BRIGHT Trial. Bivalirudin versus Heparin and Heparin plus Tirofiban in Patients with AMI Undergoing PCI. Thirty-Day and One-Year Outcomes of the Bivalirudin versus Heparin and Heparin plus Tirofiban in Patients with AMI Undergoing PCI Thirty-Day and One-Year Outcomes of the BRIGHT Trial Yaling Han, MD, FACC On behalf of the BRIGHT investigators

More information

ESC PCI Guidelines: / Sigmund Silber et al. 1

ESC PCI Guidelines: / Sigmund Silber et al. 1 For the first time! ESC PCI Guidelines: / Sigmund Silber et al. 1 in 2002: 649.332 in 2002: 541.964 ESC PCI Guidelines: Introduction and Definitions / Sigmund Silber et al. 2 ESC PCI Guidelines: Introduction

More information

GUIDELINES ON MEDICAL DEVICES EVALUATION OF CLINICAL DATA - A GUIDE FOR MANUFACTURERS AND NOTIFIED BODIES -

GUIDELINES ON MEDICAL DEVICES EVALUATION OF CLINICAL DATA - A GUIDE FOR MANUFACTURERS AND NOTIFIED BODIES - EUROPEAN COMMISSION ENTERPRISE AND INDUSTRY DIRECTORATE-GENERAL Consumer goods Cosmetics and Medical Devices MEDDEV 2.7.1 Appendix 1 December 2008 GUIDELINES ON MEDICAL DEVICES EVALUATION OF CLINICAL DATA

More information

Therapeutic Approach in Patients with Diabetes and Coronary Artery Disease

Therapeutic Approach in Patients with Diabetes and Coronary Artery Disease Home SVCC Area: English - Español - Português Therapeutic Approach in Patients with Diabetes and Coronary Artery Disease Martial G. Bourassa, MD Research Center, Montreal Heart Institute, Montreal, Quebec,

More information

HA Territory-wide PCI Audit 2003-05

HA Territory-wide PCI Audit 2003-05 HA Territory-wide PCI Audit 23-5 5 PCI Audit Working Group Central Committee (Cardiac Services) HA Convention 26 Percutaneous Coronary Intervention Background HA AP target 2/3, coordinated by PCI Working

More information

CONTRAST. (COntrast media and NephroToxicity following coronary Revascularization by AngioplaSTy)

CONTRAST. (COntrast media and NephroToxicity following coronary Revascularization by AngioplaSTy) Randomized clinical trial to compare the nephrotoxic effects of iso osmolar vs. low osmolar contrast medium in patients with impaired renal function undergoing PCI CONTRAST (COntrast media and NephroToxicity

More information

Using Clinical Registries to Create Evidence-based Health Care Policy : Experiences from Ontario, Canada

Using Clinical Registries to Create Evidence-based Health Care Policy : Experiences from Ontario, Canada Using Clinical Registries to Create Evidence-based Health Care Policy : Experiences from Ontario, Canada April 2009 Jack V. Tu, MD PhD FRCPC CANADA RESEARCH CHAIR IN HEALTH SERVICES RESEARCH Institute

More information

The Cardiac Society of Australia and New Zealand

The Cardiac Society of Australia and New Zealand The Cardiac Society of Australia and New Zealand Guidelines on Support Facilities for Coronary Angiography and Percutaneous Coronary Intervention (PCI) including Guidelines on the Performance of Procedures

More information

What is POT and Why to Do It?

What is POT and Why to Do It? San Francisco, TCT 2013, Monday Oct 28, 10:54-11:09 What is POT and Why to Do It? Carlo Di Mario, Alessio Mattesini, Gianni Dall Ara, Nicola Viceconte, Tito Kabir, Gioel Secco, Alistair Lindsay Royal Brompton

More information

Clinical Study Synopsis

Clinical Study Synopsis Clinical Study Synopsis This Clinical Study Synopsis is provided for patients and healthcare professionals to increase the transparency of Bayer's clinical research. This document is not intended to replace

More information

Dual Antiplatelet Therapy. Stephen Monroe, MD FACC Chattanooga Heart Institute

Dual Antiplatelet Therapy. Stephen Monroe, MD FACC Chattanooga Heart Institute Dual Antiplatelet Therapy Stephen Monroe, MD FACC Chattanooga Heart Institute Scope of Talk Identify the antiplatelet drugs and their mechanisms of action Review dual antiplatelet therapy in: The medical

More information

Supera Peripheral Stent System Instructions for Use

Supera Peripheral Stent System Instructions for Use Supera Peripheral Stent System Instructions for Use Table of Contents 1.0 DEVICE DESCRIPTION 2.0 HOW SUPPLIED 3.0 INDICATIONS 4.0 CONTRAINDICATIONS 5.0 WARNINGS 6.0 PRECAUTIONS 6.1 Stent Delivery System

More information

Clinical Research Intracoronary Stenting with Crushing in Coronary Artery Bifurcation Lesions: Initial Results and Medium-Term Follow Up

Clinical Research Intracoronary Stenting with Crushing in Coronary Artery Bifurcation Lesions: Initial Results and Medium-Term Follow Up Hellenic J Cardiol 45: 379-383, 2004 Clinical Research Intracoronary Stenting with Crushing in Coronary Artery Bifurcation Lesions: Initial Results and Medium-Term Follow Up PETROS S. DARDAS, DIMITRIS

More information

Stenting in Acute Myocardial Infarction

Stenting in Acute Myocardial Infarction Home SVCC Area: English - Español - Português Stenting in Acute Myocardial Infarction David Antoniucci, MD; Renato Valenti, MD Division of Cardiology and Interventional Cardiovascular Catheterization Laboratory,

More information

Databases in Clinical Research. Harvard-MIT Division of Health Sciences and Technology HST.951J: Medical Decision Support

Databases in Clinical Research. Harvard-MIT Division of Health Sciences and Technology HST.951J: Medical Decision Support Databases in Clinical Research Harvard-MIT Division of Health Sciences and Technology HST.951J: Medical Decision Support Overview Background: History and utility of clinical data repositories Strategies:

More information

None. Dual Antiplatelet Therapy Plus Systemic Anticoagulation: Bleeding Risk and Management. 76 year old male LINGO 1/5/2015

None. Dual Antiplatelet Therapy Plus Systemic Anticoagulation: Bleeding Risk and Management. 76 year old male LINGO 1/5/2015 Financial Disclosure Information Dual Antiplatelet Therapy Plus Systemic Anticoagulation: Bleeding Risk and Management Robert D. McBane, M.D. Division of Cardiology Mayo Clinic Rochester Dual Antiplatelet

More information

Earlier Access To Innovation Is It Worth It?

Earlier Access To Innovation Is It Worth It? Earlier Access To Innovation Is It Worth It? HTA Agency Perspective: Germany Dr. Alric Rüther, IQWiG Many thanks to Beate Wieseler and Stefan Sauerland for provision of slides Drivers for earlier access

More information

Optimal Duration of Dual Antiplatelet Therapy

Optimal Duration of Dual Antiplatelet Therapy Optimal Duration of Dual Antiplatelet Therapy Luis A Guzman, MD, FACC, FSCAI Associate Professor of Medicine Director, Cardiac and Vascular Cath Lab University of Florida College of Medicine - Jacksonville

More information

Marco Ferlini Struttura Semplice di Emodinamica, UO Cardiologia Dipartimento Cardiotoracovascolare Fondazione IRCCS, Policlinico San Matteo

Marco Ferlini Struttura Semplice di Emodinamica, UO Cardiologia Dipartimento Cardiotoracovascolare Fondazione IRCCS, Policlinico San Matteo Marco Ferlini Struttura Semplice di Emodinamica, UO Cardiologia Dipartimento Cardiotoracovascolare Fondazione IRCCS, Policlinico San Matteo Acute Coronary Syndromes: oral antithrombotic therapy Focus on

More information

OPTIMIZE: A Prospective, Randomized Trial of 3 Months Versus 12 Months of Dual Antiplatelet Therapy with the Endeavor Zotarolimus-Eluting Stent

OPTIMIZE: A Prospective, Randomized Trial of 3 Months Versus 12 Months of Dual Antiplatelet Therapy with the Endeavor Zotarolimus-Eluting Stent Main Arena III - Plenary Sessions XVI Late Breaking Clinical Trials III - Featured Trial of the Day: OPTIMIZE: A Prospective, Randomized Trial of 3 Months Versus 12 Months of Dual Antiplatelet Therapy

More information

Status of Drug-Eluting Coronary Stents

Status of Drug-Eluting Coronary Stents Status of Drug-Eluting Coronary Stents EVOLUTION OF PERCUTANEOUS CORONARY INTERVENTIONAL TECHNOLOGIES The introduction of percutaneous transluminal coronary angioplasty (PTCA) in the late1970s provided

More information

RX Herculink Elite Renal and Biliary Stent system Instructions for Use. RX Herculink Elite Renal Stent System. Table of Contents

RX Herculink Elite Renal and Biliary Stent system Instructions for Use. RX Herculink Elite Renal Stent System. Table of Contents RX Herculink Elite Renal and Biliary Stent system Instructions for Use Table of Contents RX Herculink Elite Renal Stent System 1.0 DEVICE DESCRIPTION Table 1. In Vitro* Device Specifications 2.0 HOW SUPPLIED

More information

DUAL ANTIPLATELET THERAPY. Dr Robert S Mvungi, MD(Dar), Mmed (Wits) FCP(SA), Cert.Cardio(SA) Phy Tanzania Cardiac Society Dar es Salaam Tanzania

DUAL ANTIPLATELET THERAPY. Dr Robert S Mvungi, MD(Dar), Mmed (Wits) FCP(SA), Cert.Cardio(SA) Phy Tanzania Cardiac Society Dar es Salaam Tanzania DUAL ANTIPLATELET THERAPY Dr Robert S Mvungi, MD(Dar), Mmed (Wits) FCP(SA), Cert.Cardio(SA) Phy Tanzania Cardiac Society Dar es Salaam Tanzania DUAL ANTIPLATELET THERAPY (DAPT) Dual antiplatelet regimen

More information

California Health and Safety Code, Section 1256.01

California Health and Safety Code, Section 1256.01 California Health and Safety Code, Section 1256.01 1256.01. (a) The Elective Percutaneous Coronary Intervention (PCI) Pilot Program is hereby established in the department. The purpose of the pilot program

More information

Main Effect of Screening for Coronary Artery Disease Using CT

Main Effect of Screening for Coronary Artery Disease Using CT Main Effect of Screening for Coronary Artery Disease Using CT Angiography on Mortality and Cardiac Events in High risk Patients with Diabetes: The FACTOR-64 Randomized Clinical Trial Joseph B. Muhlestein,

More information

High incidence of thrombus formation at 18 months after paclitaxel-eluting stent implantation: Angioscopic comparison with sirolimus-eluting stent

High incidence of thrombus formation at 18 months after paclitaxel-eluting stent implantation: Angioscopic comparison with sirolimus-eluting stent High incidence of thrombus formation at 18 months after paclitaxel-eluting stent implantation: Angioscopic comparison with sirolimus-eluting stent Masahiko Hara, MD, Masami Nishino, MD, Masayuki Taniike,

More information

COMMITTEE FOR MEDICINAL PRODUCTS FOR HUMAN USE (CHMP) DRAFT

COMMITTEE FOR MEDICINAL PRODUCTS FOR HUMAN USE (CHMP) DRAFT European Medicines Agency London, 22 March 2007 Doc. Ref. EMEA/CHMP/EWP/110540/2007 COMMITTEE FOR MEDICINAL PRODUCTS FOR HUMAN USE (CHMP) DRAFT GUIDELINE ON THE DEVELOPMENT OF MEDICINAL SUBSTANCES CONTAINED

More information

MANAGEMENT AKUTES KORONARSYNDROM: RISIKOSTRATIFIZIERUNG UND THERAPIE. Peter Wenaweser Universitätsklinik für Kardiologie

MANAGEMENT AKUTES KORONARSYNDROM: RISIKOSTRATIFIZIERUNG UND THERAPIE. Peter Wenaweser Universitätsklinik für Kardiologie MANAGEMENT AKUTES KORONARSYNDROM: RISIKOSTRATIFIZIERUNG UND THERAPIE Peter Wenaweser Universitätsklinik für Kardiologie Scientific Advances & Cardiovascular Mortality 1950 to 2010 Nabel EM and Braunwald

More information

Safety and Feasibility of Robotic Percutaneous Coronary Intervention

Safety and Feasibility of Robotic Percutaneous Coronary Intervention Journal of the American College of Cardiology Vol. 61, No. 15, 2013 2013 by the American College of Cardiology Foundation ISSN 0735-1097/$36.00 Published by Elsevier Inc. http://dx.doi.org/10.1016/j.jacc.2012.12.045

More information

OCT ASSESSMENT OF CUTTING BALLOON ANGIOPLASTY FOR IN-STENT RESTENOSIS

OCT ASSESSMENT OF CUTTING BALLOON ANGIOPLASTY FOR IN-STENT RESTENOSIS OCT ASSESSMENT OF CUTTING BALLOON ANGIOPLASTY FOR IN-STENT RESTENOSIS Division of Cardiology, Mount Sinai Hospital, New York, NY, USA Yuliya Vengrenyuk, PhD; and Annapoorna Kini, MD OCT ASSESSMENT OF CUTTING

More information

European Heart Journal (1999) 20, 1014 1019 Article No. euhj.1998.1395, available online at http://www.idealibrary.com on

European Heart Journal (1999) 20, 1014 1019 Article No. euhj.1998.1395, available online at http://www.idealibrary.com on European Heart Journal (1999) 20, 1014 1019 Article No. euhj.1998.1395, available online at http://www.idealibrary.com on Working Group Report Indications for intracoronary stent placement: the European

More information

Is There A LIfe for DES after discontinuation of Clopidogrel

Is There A LIfe for DES after discontinuation of Clopidogrel Chicago 2014 Is There A LIfe for DES after discontinuation of Clopidogrel Six-month versus 24-month dual antiplatelet therapy after implantation of drug eluting stents in patients non-resistant to aspirin:

More information

Antiaggreganti. STEMI : cosa c è di nuovo? Heartline 2015. Genova 13 14 Novembre 2015

Antiaggreganti. STEMI : cosa c è di nuovo? Heartline 2015. Genova 13 14 Novembre 2015 Heartline 2015 Genova 13 14 Novembre 2015 STEMI : cosa c è di nuovo? Antiaggreganti Luigi Oltrona Visconti Divisione di Cardiologia IRCCS Fondazione Policlinico S. Matteo Pavia STEMI : cosa c è di nuovo?

More information

Overview of Newer Stent Devices for Aneurysm Treatment

Overview of Newer Stent Devices for Aneurysm Treatment Overview of Newer Stent Devices for Aneurysm Treatment Randall C. Edgell, M.D. Associate Professor Vascular and Interventional Neurology Saint Louis University Disclosure Outcome adjudication for THERAPY,

More information

INTERVENTION IN OSTIAL CORONARY LESIONS:

INTERVENTION IN OSTIAL CORONARY LESIONS: INTERVENTION IN OSTIAL CORONARY LESIONS: Antony (92), le 18 septembre 2013 JEAN MARC PERNES Hopital Privé Antony FRANCE Perfection of Precise Ostial Stent Placement Ostial lesions, including aorta ostial

More information

ANESTHESIA FOR PATIENTS WITH CORONARY STENTS FOR NON CARDIAC SURGERY. Dr. Mahesh Vakamudi. Professor and Head

ANESTHESIA FOR PATIENTS WITH CORONARY STENTS FOR NON CARDIAC SURGERY. Dr. Mahesh Vakamudi. Professor and Head ANESTHESIA FOR PATIENTS WITH CORONARY STENTS FOR NON CARDIAC SURGERY Dr. Mahesh Vakamudi Professor and Head Department of Anesthesiology, Critical Care and Pain Medicine Sri Ramachandra University INTRODUCTION

More information

Wingspan Stent System with Gateway PTA Balloon Catheter

Wingspan Stent System with Gateway PTA Balloon Catheter Wingspan System with Gateway PTA Balloon Catheter Directions for Use AUS Australian Sponsor Address Boston Scientific (Australia) Pty Ltd PO Box 332 BOTANY NSW 1455 Australia Free Phone 1800 676 133 Free

More information

Antiplatelet and Antithrombotics From clinical trials to guidelines

Antiplatelet and Antithrombotics From clinical trials to guidelines Antiplatelet and Antithrombotics From clinical trials to guidelines Ashraf Reda, MD, FESC Prof and head of Cardiology Dep. Menofiya University Preisedent of EGYBAC Chairman of WGLVR One of the big stories

More information

Dual Antiplatelet Therapy Beyond One Year in Patients Receiving Coronary Stents for Treatment of Acute Coronary Syndromes

Dual Antiplatelet Therapy Beyond One Year in Patients Receiving Coronary Stents for Treatment of Acute Coronary Syndromes Dual Antiplatelet Therapy Beyond One Year in Patients Receiving Coronary Stents for Treatment of Acute Coronary Syndromes Robert W. Yeh, Dean J. Kereiakes, P. Gabriel Steg, Stephan Windecker, Michael J.

More information

Advances in Stent Technology

Advances in Stent Technology Nurse/Technologist Symposium Advances in Stent Technology Antonietta Tolentino, CCRN, MSN, ANP-C Adult Nurse Practitioner, Cardiac Catheterization Laboratory The Zena and Michael A. Weiner Cardiovascular

More information

PCI vs. CABG for Left Main Disease

PCI vs. CABG for Left Main Disease The EXCEL Ti Trial Design, Status, t and Timelines Gregg W. Stone, MD Columbia University Medical Center NewYork-Presbyterian Hospital Cardiovascular Research Foundation PCI vs. CABG for Left Main Disease

More information

Is Stenting or Coronary Artery By-pass Grafting the Better Treatment for This Patient?

Is Stenting or Coronary Artery By-pass Grafting the Better Treatment for This Patient? Is Stenting or Coronary Artery By-pass Grafting the Better Treatment for This Patient? --- NIRS-IVUS TVC Imaging Adds Additional Information for the Heart Team Dr. Luis Tami Memorial Regional Hospital

More information

έΰζβν αππ έκυ,νσϊίία κν1γν πλδζέκυνβί1γ π ηία δεόμνκαλ δκζόΰκμ, θν δ υγυθ άμνγνκαλ /εάμ ΚζδθδεάμΝ υλωεζδθδεάμν

έΰζβν αππ έκυ,νσϊίία κν1γν πλδζέκυνβί1γ π ηία δεόμνκαλ δκζόΰκμ, θν δ υγυθ άμνγνκαλ /εάμ ΚζδθδεάμΝ υλωεζδθδεάμν ΝΠθ ζζάθδκνσθϋ λδκν έΰκ μνεδν ιωθκ κεκη δεάμνι λδεάμ έΰζβν έκ,νσϊίί κν1γν λδζέκνβί1γ Α Α φ ; έζ δκμννένσθόμ ηί δεόμνκλ δκζόΰκμ, θν δ γθ άμνγνκλ /εάμ ΚζδθδεάμΝ λωεζδθδεάμν ένivus Scientific Director, Mediolanum

More information

REBEL monorail. Platinum Chromium Coronary Stent System ONLY. over-the-wire < EN > 2014-09

REBEL monorail. Platinum Chromium Coronary Stent System ONLY. over-the-wire < EN > 2014-09 90991566-01 REBEL monorail over-the-wire Platinum Chromium Coronary Stent System 2014-09 < EN > Table of Contents 1 WARNING:... 1 2 device description:... 1 Table 2.1 REBEL Stent System Product Description...

More information

FULL COVERAGE FOR PREVENTIVE MEDICATIONS AFTER MYOCARDIAL INFARCTION IMPACT ON RACIAL AND ETHNIC DISPARITIES

FULL COVERAGE FOR PREVENTIVE MEDICATIONS AFTER MYOCARDIAL INFARCTION IMPACT ON RACIAL AND ETHNIC DISPARITIES FULL COVERAGE FOR PREVENTIVE MEDICATIONS AFTER MYOCARDIAL INFARCTION IMPACT ON RACIAL AND ETHNIC DISPARITIES Niteesh K. Choudhry, MD, PhD Harvard Medical School Division of Pharmacoepidemiology and Pharmacoeconomics

More information

Experience of Direct Coronary Stenting at National Institute of Cardiovascular Diseases

Experience of Direct Coronary Stenting at National Institute of Cardiovascular Diseases Experience of Direct Coronary Stenting at National Institute of Cardiovascular Diseases T. Masood,T. Sagheer,D. Jan,N. Qamar,A.M.A. Faruqui ( National Institute of Cardiovascular Diseases (NICVD), Karachi.

More information

Prognostic impact of uric acid in patients with stable coronary artery disease

Prognostic impact of uric acid in patients with stable coronary artery disease Prognostic impact of uric acid in patients with stable coronary artery disease Gjin Ndrepepa, Siegmund Braun, Martin Hadamitzky, Massimiliano Fusaro, Hans-Ullrich Haase, Kathrin A. Birkmeier, Albert Schomig,

More information

Drug-Eluting Coronary Stents. Paul Montero PGY-II University of Colorado Health Sciences Center Surgical Grand Rounds Resident Debate

Drug-Eluting Coronary Stents. Paul Montero PGY-II University of Colorado Health Sciences Center Surgical Grand Rounds Resident Debate Drug-Eluting Coronary Stents Paul Montero PGY-II University of Colorado Health Sciences Center Surgical Grand Rounds Resident Debate Outline Coronary Artery Disease Evolution of Percutaneous Coronary Intervention

More information

Como mejorar el manejo médico de los diabéticos con SCA

Como mejorar el manejo médico de los diabéticos con SCA DIABETES Y ENFERMEDAD CORONARIA EN 2011 Como mejorar el manejo médico de los diabéticos con SCA Antonio Fernández-Ortiz Jueves, 20 Octubre 2011 INSTITUTO CARDIOVASCULAR Conflicto de interés: Antonio Fernández-Ortiz

More information

CORONARY BIFURCATION DISEASE AND BIFURCATION STENTING: A PRACTICAL APPROACH

CORONARY BIFURCATION DISEASE AND BIFURCATION STENTING: A PRACTICAL APPROACH CORONARY BIFURCATION DISEASE AND BIFURCATION STENTING: A PRACTICAL APPROACH Riccardo Colantonio, 1 Enrico Romagnoli, 2 *Giuseppe Sangiorgi 2,3 1. Department of Cardiology, Cardiac Cath Lab, San Pietro

More information

A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines

A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines Duration of Dual Antiplatelet Therapy: A Systematic Review for the 2016 ACC/AHA Guideline Focused Update on Duration of Dual Antiplatelet Therapy in Patients With Coronary Artery Disease A Report of the

More information

Repeat Coronary Revascularization Procedures after Successful Bare-Metal or Drug-Eluting Stent Implantation

Repeat Coronary Revascularization Procedures after Successful Bare-Metal or Drug-Eluting Stent Implantation Original Contribution Repeat Coronary Revascularization Procedures after Successful Bare-Metal or Drug-Eluting Stent Implantation Cynthia A. Yock, MS, J. Michael Isbill, MS, Spencer B. King III, MD, Mark

More information

Preoperative Cardiac Stents Perioperative Management. Mark A. Taylor, MD Department of Anesthesia

Preoperative Cardiac Stents Perioperative Management. Mark A. Taylor, MD Department of Anesthesia Preoperative Cardiac Stents Perioperative Management Mark A. Taylor, MD Department of Anesthesia Revasc prior to NCS If it offered long term benefit-- --made sense to do it 1-22 vessel CAD by angiogram,

More information

Duration of triple therapy in patients requiring oral anticoagulation after drug-eluting stent implantation (ISAR-TRIPLE Trial)

Duration of triple therapy in patients requiring oral anticoagulation after drug-eluting stent implantation (ISAR-TRIPLE Trial) Duration of triple therapy in patients requiring oral anticoagulation after drug-eluting stent implantation (ISAR-TRIPLE Trial) Katrin A. Fiedler, Michael Maeng, Julinda Mehilli, Stefanie Schulz, Robert

More information

Popliteal artery: to stent or not to stent?

Popliteal artery: to stent or not to stent? Popliteal artery: to stent or not to stent? Karl-Ludwig Schulte Vascular Center Berlin Ev. Hospital Königin Elisabeth St. Gertrauden Hospital University Hospital Charité, CC11 Humboldt-University Berlin

More information

JUL 2 2008. Ms. Kendra Basler Regulatory Affairs Associate Abbott Vascular Cardiac Therapies 3200 Lakeside Drive Santa Clara, CA 95054-2807

JUL 2 2008. Ms. Kendra Basler Regulatory Affairs Associate Abbott Vascular Cardiac Therapies 3200 Lakeside Drive Santa Clara, CA 95054-2807 DEPARTMENT OF HEALTH & HUMAN SERVICES Public Health Service JUL 2 2008 Food and Drug Administration 9200 Corporate Boulevard Rockville MD 20850 Ms. Kendra Basler Regulatory Affairs Associate Abbott Vascular

More information

When Procedural Support really matters. Navien TM A+ Intracranial Support Catheter

When Procedural Support really matters. Navien TM A+ Intracranial Support Catheter When Procedural Support really matters Navien TM A+ Intracranial Support Catheter Coils / Liquid Embolics DURABLE ovalization resistance, Maintains patent lumen in tortuosity for smooth micro catheter

More information

The Bioresorbable Vascular Stent Dr Albert Ko

The Bioresorbable Vascular Stent Dr Albert Ko The Bioresorbable Vascular Stent Dr Albert Ko Dr Albert Ko MB BS, FRACP, FCSANZ Interventional/General Cardiologist Ascot Cardiology Symposium 2013 Treatment Goals for Coronary Artery Disease Relieve of

More information

Review Article CORONARY STENTS - PAST, PRESENT AND FUTURE.

Review Article CORONARY STENTS - PAST, PRESENT AND FUTURE. Review Article CORONARY STENTS - PAST, PRESENT AND FUTURE. VV JAIN*, S YELWATKAR**, OP GUPTA*** Introduction The advent of period of angioplasty has revolutionized the practice of interventional cardiology.

More information

First Experience With Drug-Eluting Balloons in Infrapopliteal Arteries

First Experience With Drug-Eluting Balloons in Infrapopliteal Arteries Journal of the American College of Cardiology Vol. 58, No. 11, 2011 2011 by the American College of Cardiology Foundation ISSN 0735-1097/$36.00 Published by Elsevier Inc. doi:10.1016/j.jacc.2011.05.034

More information

Wertigkeit und Einsatz von bioresorbierbaren Koronarstents

Wertigkeit und Einsatz von bioresorbierbaren Koronarstents Wertigkeit und Einsatz von bioresorbierbaren Koronarstents Prof. Dr. med. Christoph A. Nienaber Universität Rostock Universitäres Herzzentrum christoph.nienaber@med.uni-rostock.de New Indications for stents:

More information

Perspectives on the Selection and Duration of Dual Antiplatelet Therapy

Perspectives on the Selection and Duration of Dual Antiplatelet Therapy Perspectives on the Selection and Duration of Dual Antiplatelet Therapy Dominick J. Angiolillo, MD, PhD, FACC, FESC, FSCAI Director of Cardiovascular Research Associate Professor of Medicine University

More information

L'aspirina è diventata obsoleta nell'era dei nuovi inbitori P2Y12? Leonardo Bolognese MD, FESC, FACC Cardiovascular Department, Arezzo, Italy ISO 9001

L'aspirina è diventata obsoleta nell'era dei nuovi inbitori P2Y12? Leonardo Bolognese MD, FESC, FACC Cardiovascular Department, Arezzo, Italy ISO 9001 L'aspirina è diventata obsoleta nell'era dei nuovi inbitori P2Y12? Leonardo Bolognese MD, FESC, FACC Cardiovascular Department, Arezzo, Italy Scientific Advances and Cardiovascular Mortality Nabel and

More information

NOVOSTE BETA-CATH SYSTEM

NOVOSTE BETA-CATH SYSTEM HOSPITAL INPATIENT AND OUTPATIENT BILLING GUIDE FOR THE NOVOSTE BETA-CATH SYSTEM INTRAVASCULAR BRACHYTHERAPY DEVICE This guide is intended solely for use as a tool to help hospital billing staff resolve

More information

Table 1. Balloon and Stent Specifications. Nominal Pressure During Stent Deployment (atm/kpa) Stent Length (mm)

Table 1. Balloon and Stent Specifications. Nominal Pressure During Stent Deployment (atm/kpa) Stent Length (mm) 90590772-01 ONLY Caution: Federal Law (USA) restricts this device to sale by or on the order of a physician. warning 2010-05 < EN > VeriFLEX (Liberté ) m o n o r a i l o v e r - t h e - w i r e Bare-Metal

More information

The BASE-ACS Trial. A Randomized Comparison of a TITAN-2 BAS with XIENCE-V- EES Stent in Acute Coronary Syndrome. 18 months Follow-up results

The BASE-ACS Trial. A Randomized Comparison of a TITAN-2 BAS with XIENCE-V- EES Stent in Acute Coronary Syndrome. 18 months Follow-up results The BASE-ACS Trial A Randomized Comparison of a TITAN-2 BAS with XIENCE-V- EES Stent in Acute Coronary Syndrome 18 months Follow-up results Pasi Karjalainen, MD, PhD, adjunct Professor on behalf of the

More information