3 bedroom, 2 bath home on 5 acres in lincoln county. hurry this home won t last!

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1 3 bedroom, 2 bath home on 5 acres in lincoln county. hurry this home won t last! Visit Lincoln County s #1 Manufactured & Modular Home Center 803 Old Moscow Mills Rd. Troy, MO The Focus News WEEKLY novemeber 2, Number 10 Volume 9 Serving St. Charles, Warren, Lincoln, Montgomery, and Franklin Counties 35 Luminesce in Warrenton Opens Wellness Center, Celebrates 5th Anniversary Luminesce Spa Salon in Warrenton is offering a new and unique approach to wellness with its new Wellness Center. They now offer a variety of group classes that range from increasing your flexibility and toning to providing extreme workouts. They also offer personal training for the person Tina Parrish, owner who excels with accountability and the support system to make and achieve goals. They offer a complementary consultation with a trainer to discuss your personal goals, options and time frame for you to get the results you are looking for. For the group classes, they are CONTINUED ON PAGE 8 Emmett Taylor, owner Old Friends Vintage Guitars Opens in Wentzville Guitar enthusiasts from everywhere should be happy to know downtown Wentzville recently welcomed the opening of Old Friends Vintage Guitars a full service guitar shop specializing in the buying, selling, tuning, repair and lessons. Located on the corner of East Allen and Linn Avenue, this guitar shop has already generated quite the buzz. Old Friends Vintage Guitars is owned by Emmett Taylor, who previously owned another guitar store in the late 70s and 80s in Oakville. Emmett is not only a veteran guitarist but involved in his contemporary rock band which has recorded a few albums that were released and available on ITunes. The albums also received some radio play time too generating more interest. Music never left me, says Emmett, who after moving to CONTINUED ON PAGE 8 Obituaries The following obituary notices are included on page Homer Avis, 88, Warrenton, veteran, construction Rev. Andrew Beck, 93, Elsberry, pastor Donald Bryant, 93, Troy, veteran, hunting guide Mildred Coker, 94, Lake St. Louis, self-employed Mabel Cunningham, 93, Montgomery City, teacher Rosemary Engemann, 82, Marthasville, homemaker Nell Grimes, 80, Eolia Albert Hannibal, 83, Dardenne Prairie, executive Donald Karrenbrock, 79, Warrenton, union carpenter Steven Mount, 55, Wright City, MEMC employee Regina Murray, 101, O'Fallon, nurse Peter Orr, 77, Warrenton, owner Jesse Purvis, 70, Lake St. Louis Vernon Schewe, 79, Lake St. Louis, veteran, industrial agri-engineer Orval Seigler, 80, Winfield, veteran Charles Smith, 80, Warrenton, machinist Patricia Tollefsrud, 59, Elsberry Sponsored by: Don t forget to order your thanksgiving CenterpieCe Still Booking Fall Weddings Fun fact:sunflowers move throughout the day in response to the movement of the sun from east to west. 511 N. Hwy 47, warrenton or Monday - Friday 9:00am to 5:30pm Saturday 9:00am to 3:00pm Funeral & Cremation Center Serving Lincoln And Pike Counties Family Owned and Operated Left, Right & Center Left, Right Starting October 27th Talk radio will change forever! you Starting are invited October 27th join Talk & in Center radio every saturday will change forever! morning

2 News Page The Focus News Weekly Publication Focus News, LLC P.O. Box St. Louis, MO Fax: Phone: (314) Editor/Publisher: Tamara See Advertising: Mir, Jill, Brandon Photography: Curtis Plunk, Alexander Brown Deadline: Tuesday prior to noon. Letters to the editor must be signed with a phone number for verification. Opinions expressed by contributors are not necessarily the views of the newspaper. The Focus News is delivered to homes & businesses in Warrenton, Wentzville, Troy, Lake St. Louis, O'Fallon & St. Peters. It is available at businesses including: Troy Drewel Realty- Brickhouse Zumba Troy Furniture & Carpet Troy Tire Scott s Home Health Medical Supply F&S Customs Corilla's Resale Apple Hearing Solutions Shared Closet Charlotte s Flowers -The Country Cottage Garden Gate Party Rental Here s 2 Eyes Lincoln Co. Animal Hospital - Zaddocks Buzzy s Liquor - Troy Elks Lodge Clayton Homes - 47 West Flea Market The Mercantile Outlet - Halo & Wings A Scrapbook & Craft Haven Troy Trading Tri-County Glass Peoples Bank & Trust Big Creek Archery Landmark Restaurant American Family Home Sales Warrenton Apple Hearing Solutions AMOG Florist Two Dudes Barbecue American Legion Kroger El Jimador Goin Postal Radio Shack - Moser s Classic Nails H & H Outfitters Curves Four Season Travel & Cruises Assist-2-Sell Lansford Treasure Chest Brockfeld s Pamper Your Pets Noah s Bark 4 Doors Down Schraer Heating & Air Conditioning Sunseekers- The Hiding Place -Raterman CPA - Dr. Paz Applebee s Chiropractic Center- FCF Church Warrenton Elks Lodge- Library Ultimate Hair & Spa Brewskies Gastorf-Schrumpf The Hideout Urban Tanz Sharper Image Wentzville SS Nutrition - Crider - Bob Evans Olive Garden - Charlie s -QT Cox & Cohea - Beauty Queen Hometown Cleaners - Coin Laundry Army Gear.net- Rural King - Dobb s Chuy s Mexican Restaurant Wentzville Eye Center - Pizza Pro Jimmy Johns - Fireside Treasures Sears Scrap To It Washington Patients First - Mind, Body & Spirt St. John s Mercy Hospital - El Charro Cartridge World - St. Louis Bread Co. Vein Specialties - Aldo s Pizza Hardee s - Joe s Bakery & Deli Manwell s Coffee - The Art Center Cowan s Restaurant - Purcell Tire Schroeder Drugs - Basket Case Rest. St. John s Medical Bldg. - BP Gourmet Cafe - Los Cabos Mexican Rest. Classic Comb Salon - Straatman Toyota Urban Accents - Phillip 66 - Bubba Shrimp Cecil Whittaker s Pizza - Mommy & Me Modern Auto - Auffenberg Montgomery City BP Brad s Kwik Store- Save-More Casey s - Central Heating & Cooling The Garage Sale Store American Bank Montgomery County Farm Bureau Montgomery City Library Senior Center Winfield Dr Haub IGA True Value Quick Stop Wellsville- IGA Fastlane Wright City American Bank Citgo Shell Economy Supermarket - Branding Iron - I-70 Subs - Revolving Door Resale Bowling Green Storch Ford - Shell - BP Hawk Point BP Sinclair Backroads Grill Unique Treasures Jonesburg Shay s Alley Fast Lane Road House Frumpy Joe s Country Side Middletown Crossroads General Country Store American Bank Country Club Bar Moscow Mills Conoco- Sunset Hair & Tan New Florence- Abel s Quick Shop BP O Fallon- Culligan, Hwy. K Businesses Silex/Auburn Thoro Mart - JR Diamonds Wentzville Board Cuts Business Fee in Half to Encourage Growth Relaxed atmosphere......affordable menu all you eat Fried chicken all day Sunday 9.99 With Mashed Potatoes & Vegetable At its first Board of Aldermen meeting in October, Wentzville s board members voted unanimously to cut the city s annual business license fee in half from 50 a year to 25 a year. According to board president Rick Stokes, this move was part of the board s overall review of the city s fees, taxes, and regulations. We want to make sure Wentzville is an inviting place for businesses to locate, especially small businesses, said Stokes. In late September the board also voted unanimously to eliminate the requirement for a city occupancy permit in the sale of an existing single-family home. Mayor Nick Guccione echoed the board s sentiment and said the city was trying to reduce the cost of doing business, and make Wentzville especially appealing to entrepreneurs and small business owners. A 25 reduction might not make a lot of difference to big retailers, but it does to small businesses and entrepreneurs, said Guccione. We re sending a message to all businesses that we want them here and are willing to work to make Wentzville a prime place for them to locate or expand, Guccione said. The mayor, in fact, made his appeal to business owners personal and invited them to contact him. If someone is interested in growing or opening a business in Wentzville, I want them to call me. I ll make sure they are put in touch with the city staff members who can help them, said Guccione. According to city records, by October Wentzville had already issued 559 business licenses, only 7 less than it issued in all of Over the past six years, the highest number of business licenses the city has issued was 620 in 2008, and the lowest number was 495 in Most years the number of business licenses issued has stayed between 561 and 569. Police Looking for Information Regarding Downtown Burglaries Wentzville Detectives are investigating a series of burglaries that are occurring near the Downtown Business District in Wentzville. The most recent break in occurred this morning at about 5 AM at the Napa Auto Parts store and was the fourth since October 1st. Other businesses that have been targeted are Wheel Sports Bike Shop, Ehll s Western Auto, and Chic Lumber. All have similar methods of entry and the intended objective is believed to be cash in each incident. Wentzville Police and the Wentzville Downtown Business Association are asking for help in identifying the people responsible for these crimes. The Wentzville Downtown Business Association has offered a reward for specific information that leads to a successful arrest and prosecution. If anyone has information regarding these incidents please contact the Wentzville Police at off any food purchase of 30 or more One coupon per table. Not valid with any other offer. Expires 10/31/ Cherry Street Troy, MO (636) THE FOCUS NEWS Friday, Novemeber 2, 2012 Former St. Louis City Building Inspector Anthony D. Davis pled guilty to bribery charges for soliciting and accepting bribes relating to his official duties of inspecting buildings and issuing permits for buildings located within St. Louis City. According to court documents, between May 20 and August 31, 2011, Davis accepted multiple illegal cash payments totaling more than 2500 in exchange for assuring that certain buildings pass inspection and issuing occupancy permits. Davis performed several acts in exchange for the illegal payments, including personally completing and submitting written inspection applications, approving electrical work while not authorized to conduct electrical inspections, handling inspections outside his assigned geographical area, and 2 Former St. Louis Building Inspector Pleads Guilty to Bribery Captain Ronald S. Johnson, commanding officer of Troop C, Weldon Spring, is pleased to announce the results of a recent enforcement detail Operation A.R.R.E.S.T. (Alcohol Related Response Enforcement Strike Team). The purpose of Operation A.R.R.E.S.T. is to increase the motoring public s awareness of the hazards of operating a motor vehicle while in an intoxicated condition. Operation A.R.R.E.S.T. was conducted from 7 p.m. on Saturday, October 27, 2012, to 3 a.m. on Sunday, October 28, 2012, in Franklin County. This eight-hour project was conducted by six officers, who focused their enforcement efforts on identifying hazardous motor vehicle operations. DWI arrests---2 giving advice on how to conceal conditions that might arouse the suspicion of building inspectors. Anthony D. Davis, St. Louis, pled guilty to two felony counts of accepting a bribe by an agent of an organization receiving federal funds before United States District Judge Henry Autrey. Sentencing has been set for January 22, Each count carries a maximum penalty of ten years in prison and/ or fines up to 250,000. In determining the actual sentences, a Judge is required to consider the U.S. Sentencing Guidelines, which provide recommended sentencing ranges. This case was investigated by the Federal Bureau of Investigation. Assistant United States Attorney Reginald Harris is handling the case for the U.S. Attorney s Office. Highway Patrol Announces Results Of "Operation A.R.R.E.S.T." In Franklin County Oil Changes Brakes State InSpectIonS Want your business featured in front of our 20,000+ readers? Speed summonses---2 Seat Belt summonses---7 Following Too Close summonses---3 Non-Moving summonses---9 Felony Drug arrests---13 Warnings---43 Total Vehicles Stopped---47 Captain Johnson stated, Alcohol continues to be responsible for approximately 30 percent of all fatal crashes on Missouri highways. Operation A.R.R.E.S.T. will assist in reducing the number of intoxicated drivers, traffic crashes, and fatalities that occur on our roadways. The Patrol encourages motorists to protect themselves from all types of hazardous drivers by making sure everyone in the vehicle is properly restrained in a seat belt or child restraint. Click It 4 Life. Not just oil... Pennzoil! 8.00 off oil change Present Coupon At Time Of Service. Offers cannot be combined. Expires: 11/30/12 9/30/12 *Excludes all trucks & early bird oil change discounts. 50 King Drive, Troy, MO Call Now:

3 New Radio Talk Show Airs on Saturday Mornings Last Saturday, Westplex News Talk KYRO 1280 launched its brand new talk show LEFT, RIGHT & CENTER. Brainchild of KYRO s in-house political sage, Bud Zeiser, this listener driven call-in show is expected to generate a massive following due to its innovative concept. Our nation is going through major turmoil and it s affecting everyone, says Bud. We wanted to create an arena where anyone, despite their political affiliations, can have an intelligent public discussion with their fellow citizens ---whether they are from the Left, Right OR Center. The show is moderated by three individuals expressing conservative, liberal and moderate political views. Matt Brunson is the left of the group, while Bud represents the right and Sean Thomas Gill is the center. While Matt, Bud and I may not always agree on everything, we do agree that the state of our politics has become more of horse race a less of an idea farm we are not talking about how things work, we are talking whose going to win, says Sean, the producer of the show. The premise of Left, Right & Center is not to introduce enraging ideas to the listening populous but to bring consensus on issues of national importance but on a scale everyone can participate. Bud says, though he is a right winger, he is against the idea of our nation prolonging its wars in Middle East and Afghanistan, which has led to the U.S. borrowing trillions of dollars from China to keep itself afloat. I don t think meddling in the Middle East is in our national interest in any shape or form. Those people have been at war with each other since David & Goliath there s never been peace in the Middle East. We are wasting our money, money we don t have, to try to create peace. And why did we open up Russia s Vietnam- obviously those people don t want us telling them what to do, and I respect that! he says. I agree, says Matt. Now one interesting result of us going into Afghanistan is our heroin on the streets went from 7% Afghani to 92% Afghani. My question is: are we in the drug business, You don t have to be a farmer to save on insurance. Sandy Turner Lincoln County Farm Bureau Agent Let me give you a FRee quote 11 Sydnorville Rd., Suite 1, Troy Fax: Cell: mofbinsurance.com because it sure seems like once we got into Afghanistan, it cleared up the shipping. Who s getting this stuff in our country? asked Bud. UK is facing a staggering 1400% increase in their surge of NOT FOR PROFIT ORGANIZATION The Artisan Guild of Warren County Presents THE 32ND ANNUAL CoUNTry CHrisTmAs 2012 CrAFT show Ad #2 Friday, Nov. 2 9 a.m. to 7 p.m. Saturday, Nov. 3 9 a.m. to 5 p.m. Sunday, Nov. 4 9 a.m. to 3 p.m. Warrenton VFW Hall Hwy. 47 South to E. Banner to Dryden admission is only 1.00 CHildren Under 12 Free! Make a fun day of it. Do your holiday shopping in our cozy country atmosphere. SCentSy PArty October 27th 3:00 p.m. You don t have to be a farmer to call Marcia. heroin also. This is coming after the fall of the Taliban which had previously banned the cultivation of poppy and opium production there. Sean says that, today there is an FARM BUREAU INSURANCE mofbinsurance.com A safe, wickless alternative to scented candles. A great gift for anyone at Christmas West terra Lane, O FaLLOn, MO north of I-70 at Lake st. Louis Blvd. exit Marcia Cox Your Mercer County Farm Bureau Agent (660) NOW OPEN Buy 1, Get 1 Frozen Yogurt FREE Redeem this coupon for one free yogurt cup with the purchase of a yogurt cup of equal or greater value. Limit 6 oz. Coupon may not be assigned, transferred or duplicated. May not be combined with any other offers. No cash value. No substitutions. Expiration Date: November 1, College Campus Dr. Moscow Mills Oil Change and Tire rotation ExpIrEs OCtObEr 31, 2012 Swirls-n-Sweets 24 95* * Some exclusions may apply This offer may not be combined with any other offer. EXPIRES 6/30/ Industrial Court / Moscow Mills, MO When Your Lower Back Issues Become A Real Pain IN THE NECK! When Do You Need To See A Chiropractor For Your Back Pain or Neck Pain? No two pain causes are alike. Your neck or back pain is as unique as you are. Yet, everyone with neck pain shared the same goal: to feel better. To reach that goal, it s helpful to understand the origin of your discomfort. Until a pain s cause or cuases are known, it s difficult to prescribe treatment. Here are a few causes of back pain or neck pain: Degenerative disc disease Herniated discs Bulging discs

4 awful lot of focus on what divides us and not what brings us together. We (republicans and democrats) all see the problems, but no one wants to give an inch. We need to compromise. Our country was founded by five different groups, and our constitution is a monument to compromise, he says. Moreover, we need to bring our conversation down to the level of the public instead at the government. Most of the arguments in Congress are about issues that are irrelevant to the general public anyway. We also need to inject common sense into the discussion; that s what the three of us would like to do in our show. If three people from different backgrounds and upbringing can agree to solve the world s problems, why can t we all! states Matt. Stop the race stereotyping and pigeonholing - we are all entitled to our opinions, but if we don t give one another a chance to voice our views there is no discussion, he says. Sean agrees. There is more branding and less Americanism or patriotism in our culture now, he says Instead of rallying around the cause, we rally around the candidate; that s wrong! You know for a fact, 90% of us vote entirely superficially. What s more important? How good the candidate looks or what he can do to get us out of the hole we are in? asks Bud. The trio hopes that ongoing discussions about healthcare primarily Obamacare, economy, jobs, oil prices, inflation, crime, abortion, 2nd Amendment and even religion will take precedence over foreign policy in their Saturday morning show. We want it to be a show that you can enjoy with your family or friends, have that dialogue and bring it to us as easily as picking up a phone, says Bud. Though they would not stray from the format, the day s topics will be revealed as the show progresses through its two hour weekend time slot. Matt says that predominantly all political talk shows have an agenda to divide the country. Their mission statement is those people are wrong, those people are always wrong and we are right. Sean responds, What s with all this fact checking; we are always trying to find whose lying and whose telling the truth, instead we should be finding out who s got a better idea. On Left, Right & Center the quest of hosts will be dissect and eliminate the rhetoric and find those ideas that can create a change. Speaking about the economy, the guys said, Up until a decade ago, Billion and Trillion were terms used in astronomy! Our bean counting has gone to absurd levels. We the public are so far removed from the concept of a billion dollars compared to our day to day check book, we can t even fathom how immense our national debt is. The hosts agree that by printing more and more borrowed money, the government is on a mission to devalue the Dollar the former measure of worldwide currency comparison. They also agreed on another issue the nonsensical overuse of political correctness. If everything offends you or me, how are we to express our views? says Bud. Barney, the purple dino offends me, does that mean we have to involve the cops? Get over it people! This message has been sent to you as a service of WINFIELD FOLEY FIREFIGHTERS ASSOCIATION Dial 911 for all emergencies HUGE JACKPOTS WEEKLY + 3,600 JACKPOT payouts at every event (if no one wins it will be higher next week) DERBYS & PULL TABS AVAILABLE TOO! Sean says that, our educational system trains us to cherish mediocrity. Children are told everyday they can be a winner- not everybody can be Stephen Hawkins or Bill Gates. If people fail teach them how to get back up; they will get on track. Every failure is another opportunity for later success. Because their parents were taught the same, now we have a nation of adults who live with their parents at 30 and expect them to take care of them. We have been setting them up for failure before they entered adulthood. Teach the children that in real life equality and fairness don t exist; trust me they ll get it, says Sean. Something else that s removed from our society is shame. Shame is also another incredibly good motivator to succeed. If you do not demand excellence you will be faced with mediocrity, says Bud. This discussion with Bud, Sean and Matt provided us with a glimpse of what the trio is capable of bringing to the listeners a radio talk show that just doesn t promise to be different it is deserving of a criteria of its own. Left, Right & Center should be an entertaining discussion for the common people. And you don t need a PhD to tune in. Left, Right & Center airs Saturday mornings on KYRO 1280 from 8 a.m. to 10 a.m. Tune In and let your voice be heard! #5 Winfield Plaza Next #5 Win eld to Hickman s Plaza IGA Every Wednesday Night & Last Saturday of Each Month. Next Doors Open to at 4:30pm Hickman's & 4:00pm on Saturday. 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5 News Page Food for Thought By: Colleen Ryan What if you forgot how to use a fork, knife or spoon? What if you didn t recognize food? What if you couldn t remember the last time you ate or what the sensation of feeling hungry meant? Would you be mad, get upset or just stop eating? We frequently receive calls from family members who are concerned about their loved one (with dementia) and their ability to eat like they once could, said Linda Desmet, Family Services Coordinator for the Alzheimer s Association St. Louis Chapter. People often think that Alzheimer s disease only effects memory, but it causes problems with memory, thinking and behavior. These problems are severe enough to interfere with daily life, including meal time. Today, more than 5.4 million Americans have Alzheimer s, and someone develops the disease every 68 seconds. Alzheimer s is the sixth leading cause of death in the United States, and the only cause of death among the top ten with no way to prevent it, cure it or slow its progression. Desmet explains that many people who call the Alzheimer s Association 24/7 Helpline are worried their loved one is not hungry at meal times and could be losing weight. Volunteers who serve on the 24/7 Helpline explain to callers that there could be a number of reasons why a loved one may not be interested in eating; they may no longer recognize the food that is placed in front of them, they may not know how to use utensils anymore, dementia can change taste buds making foods taste different or not as good. Depending on what stage of Alzheimer s a person is experiencing, they may be embarrassed to admit they are not sure how to use utensils or they may not be able to find the words to explain how they are feeling. Meal time can not only difficult for the person with the disease, but also the caregiver. Due to the disease effecting behavior, sometimes dinning becomes a daily battle. In most cases, it is possible to help your loved one (with dementia) dine with dignity and create an enjoyable experience for everyone, said Maggie Murphy- White, Education Coordinator for the Alzheimer s Association St. Louis Chapter. If your loved one becomes easily agitated trying to figure out how to use utensils, then just serve finger foods. This will help reduce agitation. You may also need to remind your loved one how to eat. Eat with them and show them how to drink or what to do with their food. That way they can try to mimic what you are doing. Also, as the disease progresses, a loved one may need additional assistance with basic things, like swallowing. Murphy-White suggests rubbing their throat to trigger the swallowing reflex. Families can learn about additional meal time tips and tricks from Jeff Goldone, the Administrator of Dining Services at Lutheran Senior Services, at the Alzheimer s Association annual Care & Conquer Conference on Thursday, November 15, 2012, at the Double- Tree Hotel and Conference Center in Chesterfield, Mo. This full-day event will provide support, education and the latest information and resources for people with dementia and people providing care to loved ones in all stages of the disease. The conference features interactive breakout sessions, worldrenowned specialists, a questionand-answer session with dementia experts, dinner, and many opportunities to connect with others battling the Alzheimer s epidemic. Participants will be entertained with an interactive, multi-sensory performance by Metro Theater Company that weaves together a tapestry of music, movement, visual art and poetry. The evening keynote presentation will feature Marc Agronin, M.D., a graduate of Harvard University and Yale Medical School, is a board-certified geriatric psychiatrist and the Director of Mental Health and Clinical Research at the Miami Jewish Health Systems, home to Florida s largest nursing home. As people with dementia and caregivers age, their perspective on growing older is too often focused on the downside of the aging process. However, this is only one side of the coin. Dr. Agronin, author of, How We Age: A Doctor s Journey into the Heart of Growing Old, will provide a spellbinding look at what aging means today how our bodies and brains age, the very way we look at aging, and what current research tells us about growing old with dementia. These strengths include a broader perspective on experience and decision-making, the potential for greater emotional maturity and enhanced creativity, and the ability to reflect on life and make positive changes that were inaccessible when younger. Put together, these new forces open a doorway of growth and possibility as we age. Many memories are made around a dinner table, and that shouldn t have to stop once your loved one is diagnosed with Alzheimer s disease, said Murphy- White. You should be able to continue to spend time with each other, family and friends at such an important place in your home. By spending time together at meal times, your loved one can still experience the atmosphere in which you made these great memories. By changing eating habits, behaviors or only eating finger foods, you can still continue the memories in a new way. If you are interested in attending the Care & Conquer Conference, have questions regarding dementia, or need support, visit or call Alzheimer s Association Care & Conquer Conference will be held on Thursday, November 15 from 1 to 8:15 p.m. at DoubleTree Hotel & Conference Center on Swingley Rd. in Chesterfield, MO. the polls say: eyeglasses - 80% contacts - 12% undecided - 8% so which way will you go? call here s 2 eyes to schedule your exam vote today! #31 Troy Square, Troy, MO Monday-Friday 9am-6pm Saturday 9am-2pm ClOSed Sunday THE FOCUS NEWS Friday, Novemeber 2, Charlie Boyce Elected President of Home Builders Association Charlie Boyce Charlie Boyce, president of Innsbrook Corporation, has been elected the 79th president of the Home Builders Association (HBA) of St. Louis & Eastern Missouri. The HBA is a local trade association of more than 600 member firms representing the residential construction industry. The Focus TURN UP THE HEAT ON YOUR MARKETING! 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6 Health Page Yeast Model Offers Clues to Possible Drug Target for Lou Gehrig's Disease Amyotrophic lateral sclerosis, also called Lou Gehrig s disease, is a devastatingly cruel neurodegenerative disorder that robs sufferers of the ability to move, speak and, finally, breathe. Now researchers at the Stanford University School of Medicine and San Francisco s Gladstone Institutes have used baker s yeast a tiny, one-celled organism to identify a chink in the armor of the currently incurable disease that may eventually lead to new therapies for human patients. Even though yeast and humans are separated by a billion years of evolution, we were able to use the power of yeast genetics to identify an unexpected potential drug target for ALS, said Aaron Gitler, PhD, an associate professor of genetics at Stanford. Many neurodegenerative disorders such as ALS, Parkinson s and Alzheimer s exhibit protein clumping or misfolding within the neurons that is thought to either cause or contribute to the conditions. We are trying to figure out why these proteins aggregate in neurons in the brain and spinal cord, and what happens when they do. In 2008, Gitler received a New Innovator award from the National Institutes of Health to use yeast as a model for understanding human neurodegenerative diseases and as a way to identify new targets for drug development. Gitler is the co-senior author of the research, which will be published online Oct. 28 in Nature Genetics. Robert Farese, Jr., MD, a senior investigator at the Gladstone Institutes, is the other co-senior author. Stanford graduate student Maria Armakola shares co-first authorship with Matthew Higgins, PhD, a postdoctoral scholar at Gladstone. Most cases of ALS have no clear-cut cause. However, it has recently been shown that an RNAbinding protein called TDP-43 accumulates in clumps in the cytoplasm of spinal cord neurons in many people with the condition, and mutations in this protein have been found in some people with the ALS. Researchers like Gitler and Farese have been able to mimic the disease in yeast by expressing TDP-43 at higher-than-normal levels, which causes the protein to form lethal clumps in the cells cytoplasm. In humans, the progression of the disease can take years before symptoms arise, said Gitler. But in yeast, we see protein clumping in the cytoplasm within two days and the cells rapidly begin to die. With their model system in place, Gitler and Farese set out to see whether it was possible to protect yeast cells from this effect by tinkering with the function of other proteins in the cell. In this study, the researchers discovered that blocking the production of a protein called Dbr1 in a yeast model stops the TDP- 43 clumping and allows the cells to live normally. The researchers confirmed the results in human nerve cells grown in the laboratory and in rat neurons overexpressing TDP-43. In this study we made no assumptions as to how TDP-43 injures cells, said Farese, but instead screened the whole yeast genome to find genes that might prevent the toxicity. Independently, both our lab and the Gitler lab found that loss of Dbr1, an enzyme involved in RNA processing, could do this. continued on page 12 Novemeber 2012 Offer: 500 off Invisalign plus Free Whitening (over a 1000 savings) Genetics, for many people, often boils down to a few simple questions. Do I have the gene sequence responsible for my mother s cancer? Will I be as tall as my uncle? Will my children have fair hair, or dark? Will they have dimples? Who in my family might develop asthma or diabetes? Unfortunately, there are few clear-cut answers, particularly in ethnic groups or populations whose genomes have not been well-studied. This is a particular problem when trying to translate genomic information into clinical applications and medical recommendations. Researchers at the Stanford University School of Medicine and around the world are still working to understand which variations among the billions of nucleotides in our DNA are functionally important, and which are merely the THE FOCUS NEWS Friday, Novemeber 2, 2012 Findings From International Genomics Project Describe Variations Among Ethnic Groups, Says Stanford Scientist Eliminating bacteria s DNA and boosting antimicrobial proteins that already exist may help prevent middle ear infections from reoccurring. These are the findings from a Nationwide Children s Hospital study that examined how an immune defense protein common in the middle ear interacts with a structure meant to protect a colony of bacteria. The bacterium nontypeable Haemophilus influenzae (NTHI) causes a wide range of diseases of both the lower and upper airways, including middle ear infection. NTHI, like most other bacteria, can form a biofilm, a robust community of bacteria that allows the bacteria to evade the host s immune system and protects the bacteria from antibiotics and other therapies designed to kill them. Human beta-defensin-3 is A new Down syndrome patient registry will facilitate contacts and information sharing among families, patients, researchers and parent groups. The National Institutes of Health has awarded a contract to PatientCrossroads to operate the registry. The company has created patient-centric registries for muscular dystrophy and many rare disorders. People with Down syndrome or their family members will be able to enter contact information and health history in an online, secure, confidential database. Registry participants will be able to customize their profile, update it online, and choose which information they would like to display, including reminders about their own medical care and general information about result of the genetic noise inherent in the messy process of human reproduction. Now, the international 1,000 Genomes Project has catalogued more than 38 million single-nucleotide variations, called SNPs, and several million other genetic changes in over 1,000 people from 14 populations in four main geographic regions: Europe, Africa, East Asia and the Americas. The results will be published Oct. 31 in Nature. Studies like these will directly benefit some of our most medically underserved populations, while also helping all of us by increasing our knowledge of naturally occurring genetic variation, said Carlos Bustamante, PhD, a professor of genetics at Stanford. There s a real need for these types of tools and resources. In particular, the researcher an antimicrobial defense protein expressed in the middle ear of humans and other mammals that kills both Gram-positive and Gram-negative bacteria. Previous research has shown that if expression of beta-defensin is disrupted, the host s ability to control the bacteria in the upper airway is altered and infection worsens. Investigators in The Research Institute at Nationwide Children s Hospital hypothesized that human beta-defensin-3 might lose its power to kill NTHI if it got caught up within the extracellular DNA that makes up a biofilm s outer layer, thus preventing its contact with bacteria within the biofilm. When the team exposed the bacteria that cause ear infections to a concentration of human-beta defensin-3 that is typically detected in the a middle ear of a child Down syndrome. They also will be able to compare their own medical information to that of other registrants in a confidential and anonymous manner. If a participant gives permission to be contacted, clinicians and researchers who are authorized to access the database will be able to contact these individuals to see if they are interested in participating in a research study. Ultimately, the registry will be able to link to biorepositories of tissue samples and other resources, with the goal of making it easier for patients to take part in clinical studies for new medications and other treatments for Down syndrome. The contract, which will support the creation of the registry through September 2013, received 6 found that the relative prevalence of rare and common variants can differ widely between specific populations. For example, a rare genetic change (defined as those found in fewer than 0.5 percent of samples) linked to disease in one population is not likely to occur in another, and even more-common genetic variants (occurring in 1 to 2 percent of samples) may not be shared among populations in different parts of the world. Bustamante is one of the principal investigators of the study. Gil McVean, PhD, a professor of statistical genetics at the University of Oxford, is the senior author. More than 100 institutions and hundreds of individual scientists are listed as co-authors on the paper. Bustamante and colleagues urged the inclusion of populations from the Americas includcontinued on page 17 Study Suggests New Way to Prevent Recurrent Ear Infections with active infection, the peptide was able to kill 100 percent of the NTHI, but the killing stopped when extracellular DNA was introduced to the reaction. Dr. Bakaletz says this study provides evidence for a new treatment regimen to target biofilms formed by NTHI during middle ear infection. One approach would be to deliver a therapeutic agent that can disrupt bacterial DNA, in conjunction with human betadefensin-3 to the middle ear of a child with chronic, recurrent infection. Physicians could follow the same pathway used to target the middle ear during ear tube surgery, a common treatment for chronic ear infections. Doing so could help diminish the recurrent nature of middle ear infection. NIH Establishes Down Syndrome Patient Registry 300,000 in funding for its first year. "The new registry provides an important resource to individuals with Down syndrome and their families," said Yvonne T. Maddox, deputy director of the NIH's Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), which is funding the registry. "The registry links those seeking volunteers for their research studies with those who most stand to benefit from the research." Down syndrome most frequently results from an extra copy of chromosome 21 in the body s cells. Infants with Down syndrome are likely to have certain physical characteristics, such as short stature and distinctive facial features, continued on page 10

7 Health Page Researchers have learned how a man-made molecule destroys complexes that induce allergic responses a discovery that could lead to the development of highly potent, rapidly acting interventions for a host of acute allergic reactions. The study, which will be published online Oct. 28 in Nature, was led by scientists at the Stanford University School of Medicine and the University of Bern, Switzerland. The new inhibitor disarms IgE antibodies, pivotal players in acute allergies, by detaching the antibody from its partner in crime, a molecule called FcR. (Other mechanisms lead to slower-developing allergic reactions.) It would be an incredible intervention if you could rapidly disconnect IgE antibodies in the midst of an acute allergic response, said Ted Jardetzky, PhD, professor of structural biology and senior investigator for the study. It turns out the inhibitor used by the team does just that. A myriad of allergens, ranging from ragweed pollen to bee venom to peanuts, can set off IgE antibodies, resulting in allergic reactions within seconds. The new inhibitor destroys the complex that tethers IgE to the cells responsible for the reaction, called mast cells. Severing this connection would be the holy grail of IgE-targeted allergy treatment. The first time a potential allergen enters the body, some people respond by making allergen-specific IgE antibodies. These antibodies stick around long after the initial allergen is cleared from the body. Most of the antibodies get snagged by IgE-specific receptors called FcRs, which are exposed on Schizophrenia & Autism Close Relations? Autism Spectrum Disorders (ASD), a category that includes autism, Asperger Syndrome, and Pervasive Developmental Disorder, are characterized by difficulty with social interaction and communication, or repetitive behaviors. The U.S. Centers for Disease Control and Management says that one in 88 children in the US is somewhere on the Autism spectrum an alarming ten-fold increase in the last four decades. New research by Dr. Mark Weiser of Tel Aviv University's Sackler Faculty of Medicine and the Sheba Medical Center has revealed that ASD appears share a root cause with other mental illnesses, including schizophrenia and bipolar disorder. At first glance, schizophrenia and autism may look like completely different illnesses, he says. But closer inspection reveals many common traits, including social and cognitive dysfunction and a decreased ability to lead normal lives and function in the real world. Mechanism Found for Destruction of Key Allergy-Inducing Compounds New research reports that women with systemic lupus erythematosus (SLE) have a two-fold increase in risk of preeclampsia a dangerous condition in which pregnant women develop high blood pressure (hypertension) and protein in their urine (proteinuria) after 20 weeks of gestation. According to the findings published inarthritis Care & Research, a journal of the American College of Rheumatology (ACR), use of Disease- Modifying Antirheumatic Drugs (DMARDs) during pregnancy was rare in the study population, but women who did use these medications show a statistically non-significant increase in preeclampsia risk. The risk could be explained by the severity of autoimmune disease among DMARD users. Patients with autoimmune diseases such as SLE and rheumatoid arthritis (RA) are typically treated Studying extensive databases in Israel and Sweden, the researchers discovered that the two illnesses had a genetic link, representing a heightened risk within families. They found that people who have a schizophrenic sibling are 12 times more likely to have autism than those with no schizophrenia in the family. The presence of bipolar disorder in a sibling showed a similar pattern of association, but to a lesser degree. A scientific leap forward, this study sheds new light on the genetics of these disorders. The results will help scientists better understand the genetics of mental illness, says Dr. Weiser, and may prove to be a fruitful direction for future research. The findings have been published in the Archives of General Psychiatry. Researchers used three data sets, one in Israel and two in Sweden, to determine the familial connection between schizophrenia and autism. The Israeli database alone, used under the auspices of with DMARDs to prevent disease flares. DMARDs are a class of medications that treat the underlying autoimmune disease, not just symptoms of these diseases, and include: methotrexate (Rheumatrex, Trexall); anti-malarial drugs such as hydroxycholorquine (Plaquenil); and biologics such as etanercept (Enbrel) or adalimumab (Humira). "Understanding how DMARD use impacts women with autoimmune disease is important, especially during pregnancy, as previous research found that women with SLE had at least a two-fold increase in preeclampsia risk and women with RA had a two-fold increase of this severe pregnancy complication," said lead author Kristin Palmsten from Harvard School of Public Health. To compare risk of preeclampsia in DMARD users, researchers the ethics committees of both the Sheba Medical Center and the Israeli Defense Forces, included anonymous information about more than a million soldiers, including patients with schizophrenia and ASD. "We found the same results in all three data sets," he says, noting that the ability to replicate the findings across these extensive databases is what makes this study so significant. Understanding this genetic connection could be a missing link, Dr. Weiser says, and provides a fresh direction for study. The researchers are now taking this research in a clinical direction. For now, though, the findings shouldn't influence the way that doctors treat patients with either illness, he adds. This work was done in collaboration with researchers at the University of North Carolina, Karolinska Institute in Sweden, Kings College London, and the Israeli Defense Force Medical Corps. the surface of mast cells. The mast cells are then primed to react the next time a person encounters the allergen. Dissociation of this IgE-FcR interaction is a sought-after goal of allergy treatment for a good reason: IgE-coated mast cells are grenades of histamine, and re-encountering the allergen is equivalent to pulling out the clip. When an allergen makes a return visit, it binds to the pre-loaded IgE on the mast cell surface, triggering the release of inflammatory mediators including histamine that promote the allergic response. As allergy sufferers are well aware, these nasty reactions can occur within a matter of seconds. In a severe allergic response, sudden anaphylactic shock and death can be the result. The key to actively disabling the allergic response lies in the continued on page 15 Women With Lupus Have a Higher Risk for Preeclampsia used the British Columbia healthcare utilization database to identify 306,831 pregnancies in 224,827 women with and without autoimmune disease. Women who filled a prescription for DMARDs, nonsteroidal anti-inflammatory drugs (NSAIDs), or corticosteroids before pregnancy were considered "past users" and those who filled these prescriptions both before and during the first 20 weeks of pregnancy were designated "continuous users." Results show that pregnant women in this study had a median age of 30 years, with 0.3% of women diagnosed with RA or psoriasis; 0.2% with inflammatory bowel disease (IBS); 0.1% with SLE, and another 0.1% with multiple sclerosis (MS). Within this cohort, researchers found that 1,226 (0.4%) women used a DMARD in the continued on page 11 THE FOCUS NEWS Friday, Novemeber 2, 2012 Would you take part in a weight-loss program in which you were explicitly asked not to lose any weight for the first eight weeks? Although the approach sounds counterintuitive, a study from researchers at the Stanford University School of Medicine found that women who spent eight weeks mastering weight-maintenance skills before embarking on a weight-loss program shed the same number of pounds as women who started a weight-loss program immediately. More importantly, the study showed that the maintenance-first women had regained only 3 pounds on average a year later, compared to the average 7-pound gain for the immediate dieters. The study s authors say that the maintenance-first approach may offer a way to halt the cycle of yoyo dieting. Those eight weeks were like a practice run. Women could try out different stability skills and work out the kinks without the pressure of worrying about how much weight they had lost, said lead author Michaela Kiernan, PhD, senior research scientist at the Stanford Prevention Research Center. We found that waiting those eight weeks didn t make the women any less successful at losing weight. But even better, women who practiced stability first were more successful in maintaining that loss after a year. The study will be published online Oct. 31 in the Journal of Consulting and Clinical Psychology. Obesity contributes to a variety of health problems, including heart disease and diabetes. Previous research has shown that losing 5-10 percent of your body weight can decrease the risk factors for heart disease. Yet despite the plethora of diet books and programs, many people who lose weight are unable to keep it off. Over the years, Kiernan has interviewed both those who have succeeded and those who have 7 Mastering Weight- Maintenance Skills Before Embarking on Diet Helps Women Avoid Backsliding failed at keeping the pounds off. She was particularly struck by one woman who said that she had never maintained her weight in her life; instead, she was always either losing or gaining. She had no sense what she was aiming for, Kiernan said. We wanted to see if there was a way to help people get away from this allor-nothing approach that is associated with losing weight. Kiernan noted that weight maintenance may require a different set of skills and behaviors than those used for losing weight. So she and her colleagues came up with the idea to teach weight-maintenance skills first so that people could experience how to fine-tune their behavior in response to everyday pleasures and disruptions rather than being on or off a diet. Among these stability skills are searching out low-fat or lowcalorie foods that taste as good as high-fat/high-calorie options to avoid feelings of deprivation; occasionally eating and savoring small amounts of favorite high-fat/highcalorie foods; weighing daily to see how their body weight naturally fluctuates from day to day; identifying a personalized weight-fluctuation range of about 5 pounds to account for common disruptions, such as water gain and vacations; strategically losing a few pounds before a known disruption (such as a vacation) to minimize its effects; and eating a little more when reaching the lower limit of the personalized 5-pound range. Kiernan said the approach is designed to help people make peace with the scale and learn how to pay relaxed attention to their weight in ways that can be maintained over the long term without keeping food records. Losing a significant amount of weight requires a lot of focused attention to what you re doing, and most people can t keep up that intensity over the long term, Kiernan said. For weight maintenance, we wanted something that continued on page 18

8 News Page Luminesce Salon & Wellness...CONTINUED FROM FRONT THE FOCUS NEWS Friday, Novemeber 2, Old Friends Guitars...CONTINUED FROM FRONT currently offering a package of ten classes for 50 (which are good for a three month time frame) or unlimited monthly group classes for 50. With either package you can use your credits to take any or a variety of the classes. You can mix or match. They welcome drop in guests as long as the classes are not filled to capacity. They would love for everyone to experience the Luminesce difference -- come by and try a complementary class or drop by for a tour. Their group classes offer fitness in an intimate environment, your class and only your class will be going on at one time. "Our focus is you, your comfort and well being. We want to give you an environment to support your needs and give you the tools to excel," said owner, Tina Parish. The Wellness Center's yoga classes are designed for the beginning student to learn the essential elements of yoga practice. Teachers instruct basic postures, the core actions that support and open the body, linking movement to breath, connecting postures, and focusing attention. Of all forms of movement, Yoga is one of the most universally recommended, and one of the most effective from a holistic standpoint. There are poses designed to work every muscle and joint of the body and to stimulate the body's cardiovascular, digestive, nervous and endocrine systems. Yogo promotes optimal body function so that we are physically and emotionally free of stress, a benefit for all generations and every degree of ability. Range of Motion is a blend of Yoga, Pilates and some acceleration of your heart rate. This class is designed to be well-rounded, working with balance, posture and movement. Zumba classes feature exotic rhythms set to high-energy Latin and international beats. Before participants know it, they're getting fit and their energy levels are soaring! There's no other fitness class like Zumba Fitness-Party. It's easy to do, effective and totally exhilarating, often building a deeprooted community among returning students. Zumba toning classes are designed to sculpt your body. Zumba Toning raises the bar (or rather, the toning stick). It combines targeted body-sculpting exercises and high-energy cardio work with Latin-infused Zumba moves to create a calorie-torching, strengthtraining dance fitness-party. Students learn how to use lightweight, maraca-like Toning Sticks to enhance rhythm and tone all their target zones, including arms, abs, glutes and thighs. Zumba Toning is the perfect way for enthusiasts to sculpt their bodies naturally while having a total blast. Turbo Kick is the hottest kick boxing class around for fitness training. It is a fusion of hip hop and kick boxing and provides an intense workout. The unique Turbo Kick movement patterns, combinations and techniques work together to give the ultimate cardiovascular workout. Each full body workout is designed to maximize results and have fun at the same time. Turbo Kick allows participants of any fitness level to participate and custom tailor their workouts. With their expansion they have also added another treatment room where they are able to offer massage for both relaxation and therapy. They offer a variety of massages and treatments. Their massage therapists have been trained in sport, therapeutic, isolative stretching, deep tissue, reflexology, and relaxation massage. Massage has been proven to be instrumental in the healing process. In an age of technical and, at times, impersonal medicine, massage is a drug-free, non-invasive and humanistic approach based on the body's natural ability to heal itself. Receiving regular massage and/or bodywork treatments provides several benefits: Increases circulation, allowing the body to pump more oxygen and nutrients into tissues and vital organs. Stimulates the flow of lymph, the body's natural defense system, against toxic invaders. For example, in breast cancer patients, massage has been shown to increase the cells that fight cancer. Increases circulation of blood and lymph systems and improves the condition of the body's largest organ - the skin. Relaxes and softens injured and overused muscles. Reduces spasms and cramping. Increases joint flexibility. Reduces recovery time, helps prepare for strenuous workouts and eliminates subsequent pains of the athlete at any level. Releases endorphins - the body's natural painkiller - and is used in chronic illness, injury and recovery from surgery to control and relieve pain. Reduces post-surgery adhesions and edema and can be used to reduce and realign scar tissue after healing has occurred. Improves range-of-motion and decreases discomfort for patients with low back pain. Relieves pain for migraine sufferers and decreases the need for medication. Provides exercise and stretching for atrophied muscles and reduces shortening of the muscles for those with restricted range of motion. Assists with shorter labor for expectant mothers, as well as need for medication, less depression and anxiety, and shorter hospital stays. "We believe that beauty radiates from within all of us. It is our passion to enhance both your inner and outer beauty. Our salon team is dedicated to ongoing advanced education as well as legendary customer service. We have celebrated our five year anniversary in business and we are very blessed with amazing clients, a beautiful, energetic environment, and a team who is dedicated to serve," Tina explained. Luminesce Salon & Wellness Center is located at 702 N. Hwy. 47 in Warrenton, Missouri. Their hours are Monday, 9 a.m. to 4 p.m.; Tuesday through Friday, 9 a.m. to 9 p.m.; and Saturday, 9 a.m. to 4 p.m. and can be reached at (636) More information and the current calendar of events is available at Wentzville a few years ago started looking for a place to open a neighborhood guitar shop. When Kevin opened this guitar shop last year to sell primarily older and vintage guitars from his personal collection, the place interested me so much, I made a deal to buy the whole store. After purchasing, Emmett renovated the store to accommodate more inventory of both vintage and collectible as well as entry level guitars. He also built a couple of music rooms in the rear of store where guitar lessons can be rendered. As the name suggests, Old Friends Vintage Guitars carry a fantastic selection of collectible grade guitars which generally interest the aficionados, collectors and professional guitarist. But the walls are also lined with many acoustic and electric guitars for the beginners too. Emmett says the draw for vintage guitars among discriminating and accomplished guitarists is in the quality, craftsmanship and of course the sound. When you are getting a vintage guitar, you are looking for all those and more especially because the mass production lines nowadays cannot deliver those values. May be they are looking for a particular guitar to match their taste, he said as he showed us a 1919 Gibson model L3 acoustic in amazing condition that is currently the oldest guitar in the store. A beautiful Guild 12 string from 1968 had also come in for repair. Emmett s vision for the store is to continue to be a unique venue where you can be comfortable, sit down and play guitar in a family and community atmosphere. Our primary goal at Old Friends Guitars is to be welcoming place for every type of music lover to gather, socialize over a cup of coffee and play or listen to some great music. That s why it was named Old Friends. says Emmett. To that end, the store has been quite successful. Every evening you can find several guitarists- -both budding and experiencedexchanging skills, styles and tips as they listen to each other play. Sometimes people just gather to listen, it s a great meeting place, adds Emmett. Open mic session will be held once a month too and interested individuals are asked to register. For the intermediate and beginner players, Old Friends Vintage Guitars carry a number of accessories from amplifiers to picks. You can also get your guitar tuned or repaired by a professional at the store too. Instructors are available on staff to provide lessons. John Szepanski is an accomplished guitar player who is our primary instructor here. Several people have stopped in already to enroll in the classes, but times are still available, adds Emmett. Parents bringing their children in for lesson can enjoy the Wi-Fi and fresh coffee which are both on the house at Old Friends Vintage Guitars. Available for purchase is a delicious blend of coffee curiously labeled String Beans- a creation of a local guitarist. In Spring, Old Friends Vintage Guitars will be hosting Wenztville s first Blue and Rock festival on the parking lot. Date will be announced soon. On November 10th, the store is hosting their Grand Opening & Open House. Emmett and the staff of Old Friends Vintage Guitars would like to take the opportunity to invite everyone to come visit, hang out and play some tunes. See the store and experience the ambience and be sure to tell them you saw in The Focus. Old Friends Vintage Guitar is located at 1 E. Allen in Wentzville and can be contacted at and on the web at

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10 Down Syndrome...CONTINUED FROM PAGE 6 as well as health conditions like hearing loss, heart malformations, digestive problems, and vision disorders. Although Down syndrome most commonly results in mild to moderate intellectual disability, the condition occasionally involves severe intellectual disability. In addition, some individuals with Down syndrome age prematurely and may experience dementia, memory loss, or impaired judgment similar to that experienced by individuals with Alzheimer disease. "Down syndrome is complex," Dr. Maddox said. "A wide array of scientific expertise is required to address all its aspects in a comprehensive manner." Development of a patient registry was a leading recommendation in the 2007 NIH Down Syndrome Brenda Sue s Research Plan, which sets goals and objectives for the Down syndrome research field. Together with the Global Down Syndrome Foundation, the NICHD sponsored the Down syndrome National Conference on Patient Registries, Research Databases, and Biobanks to solicit the advice of a number of experts from the advocacy community, federal agencies, industry, and the clinical and research communities on how best to establish a Down syndrome registry. The plan for the registry was supported by the public-private Down Syndrome Consortium, which was established by the NIH in 2011 to foster the exchange of information on Down syndrome research, and to implement and update the Research Plan. Membership on the Consortium includes individuals with Down syndrome and family members, representatives from prominent Down syndrome and pediatric organizations, and members of the NIH Down Syndrome Working group, an internal NIH group that coordinates NIH-supported Down syndrome research. "We're grateful to those who provided us with the advice that allowed us to establish a national registry," Dr. Maddox said. "We are happy that this important step in furthering research on Down syndrome has been accomplished and hope that many families will take advantage of the opportunity to sign up as soon as the registry goes online." AT&T Completes Stolen Phone Database to Help Curb Mobile PhoneTheft AT&T has announced the completion of the second phase of its stolen phone database, which enables customers to report and block stolen wireless devices. AT&T is now able to share data on stolen phones with other GSM carriers, allowing a reported stolen phone to be disabled on AT&T s network. Customers may report a stolen phone and suspend their service online at at an AT&T store, or by contacting AT&T Customer Care at Within 24 hours, AT&T will block the use of a device reported as stolen. Earlier this year, AT&T joined Senator Schumer, FCC Chairman Julius Genachowski, New York Police Commissioner Ray Kelly, Washington, D.C. Police Chief Cathy Lanier, NYPD Deputy Chief Phil Pulaski and other wireless carriers at an event to discuss the growing problem of wireless de- vice theft, said Bob Quinn, senior vice president of Federal Regulatory and Chief Privacy Officer. As part of our many efforts to address this important issue, we launched a new website in May to help educate our customers on protecting their wireless device, and in July we began the initial phase of our stolen phone database. Our customers safety is a top priority for AT&T and we look forward to continuing our work in this area. Buy 1 item at Regular Price & 1/2 OFF 25% OFF CHILDREN S Get 1/2 Off Any Item of Equal or COSTUME any Gift Certificates purchased in Nov. & Dec. at Relax-U for Massage & Reiki Lesser Value ChiropraCtor injury & Wellness treatments dr. jon owens, d.c. Missouri Injury & Wellness Chiropractic Centers We get great results even for folks who have tried other forms of therapy. Soft tissue release to relieve symptoms such as pain, numbness & tingling. MIssourI Injury & Wellness ChIropraCtIC Centers 100 West second street n, suite D Wright City, Mo We are the muscle & joint experts of Warren County! massage therapy Relax- U, monday by appointment! FREE Reiki Share Event on Nov. 17th Treat Yourself to Better Health LLC When you buy 1 of equal or lesser value. With Relaxing, Therapeutic Massage Expires this coupon. 10/31/12 Exp. 10/16/10 Hermann & Warrenton locations Denise K. Albritton, NCBLMT, EFT-ADV Costume Sales & Rentals 101 E. Main WARRENTON, MO Full Line Costume Shop! pumpkins also come in green, blue and white New Client Special 39 1 Hour Massage Now in wright City: Mondays washington: tuesday - Friday Massage therapy Call today to schedule your appointment Visit us online vein screening! now offering painless laser tattoo removal

11 Preeclampsia...CONTINUED FROM PAGE 7 year prior to pregnancy, while only (RR=2.02) compared to women was reduced when we more fully 414 (0.1%) women used DMARDs without an autoimmune disease. accounted for the potential effect while pregnant. The occurrence Restricting the analysis to women of the autoimmune diseases, suggesting of preeclampsia in past DMARD, with autoimmune diseases weakened that the underlying disease steroid, NSAIDs users was 2.3%, the preeclampsia relative risk or severity of the disease was likely 2.7%, and 2.9%, respectively. in DMARD users. contributing to the increased risk Further analysis indicates that Ms. Palmsten concludes, "Our of preeclampsia among DMARD a continuous DMARD user was at findings uphold previous evidence, users." The authors advise that fur- greater risk of preeclampsia (relative showing that women with ther studies are needed to confirm risk (RR) =2.29; not statistically SLE had twice the risk of develop- their findings, and research should significant) compared to past ing preeclampsia. The statistically focus on DMARD use and pre- DMARD users. Preeclampsia risk non-significant increase in preeclampsia eclampsia in women with specific was greater in women with SLE risk found for DMARDs autoimmune diseases. Lisa sitler for County Coroner Resident of Lincoln County 15 years / Married to Marc Sitler 25 yrs. PhD Sping 2012 Nursing, RN, Advanced Public Health Nurse, Board Certified Am. Nurses Associations 2011, Sexual Assault Nurse Examiner 2004, Forensic Medical Training 2011, Treasurer Sigma Theta Tau Nursing Honor Society, Lin-Co Maternal Child Health Coordinator, Educator, 30+ yrs. Business Management / 4 yrs. adjunct Nursing Faculty Member Lincoln County Child Fatality Review Board, Chair Lincoln Community Safety Task Force, Pres. for the MO Extension Council of Lincoln County, Troy Kiwanis, 4-H Leader If I am elected I will have the opportunity to provide professional and caring service to our residents! Vanessa Guyot for County CLerk Lifetime resident Lincoln County / Married to Greg Guyot 33 years Business Owner 25+ yrs., Grad Troy Buchanan High School / Grad Missouri Baptist w/ Assoc. in Business Graduate of Real Estate Institute - Independent Broker/GRI McDonnell Douglas - Secret Clearance in Laser Communications United Postal Service Carrier and Clerk, Bookkeeper & Manager Retail Member - St. Mary s Church, Past President VFW Ladies Aux Post Past President Chamber Commerce, LC Republican Party My mission is to provide an Honest Professional Office with a Seasoned & Knowledgeable Staff to Serve the Public! CaroL WesseLL Boyer for PuBLiC administrator Real Estate Agent since 1987 / Prior co-owner cattle farm Co-owned family business/bookkeeping, Coordinator & Secretary Member First Baptist Church Troy, Director Moral Issues Committee, Vice Chair Christian Life Committee MO Baptist Convention, Past leader Celebrate Recover, Appointed to Citizens Advisory Board Dept. of Corrections 2008, Sponsor for Right Track Youth Awareness Group Dept. Corrections Past Member Criminal Justice Task Force Jeff. City, Lift Member Ladies Aux. VFX Treas. 3 yrs., Concerned Women for America, MO Right to Life, Past Chair Lincoln County GOP Central Commitee Paid for by Lisa Sitler for Coroner, Ida C. Ebert, Treasurer Paid for by Committee to elect Vanessa Guyot for County Clerk Paid for by Candidate 10 group FiTNeSS classes FOr Expires in 3 months. group classes include Yoga, Zumba, Zumba Toning & Turbo Kick. Luminesce Salon Spa & Wellness Our Focus is You 702 N. 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12 Lou Gehrigs...CONTINUED FROM PAGE 6 Dbr1 serves as part of the cellular clean-up crew that mops up the bits of unwanted RNA generated as part of the protein production line. In our DNA, most genes consist of coding regions, called exons, broken up into several segments by non-coding regions, called introns. Cells can make many different, related proteins from the same stretch of DNA by mixing and matching different exons in a process called splicing. When the DNA is first copied, or transcribed, into RNA, the introns as well as the exons are included. But the cell quickly splices out the introns, which are released into the cytoplasm as little loops, or lariats. Dbr1, in turn, clips the loops to open them and make them accessible to the cell s disposal system. Blocking the production of Dbr1 causes the RNA lariats to build up in the cytoplasm. The researchers showed by creating lariats with a binding site for a fluorescent tracking protein that the mutant TDP-43 binds to these excess lariats rather than clumping. The effect is like using a paper towel to mop up a spill on your computer keyboard: binding to the lariats appears to keep TDP43 from causing havoc elsewhere. Normally, TDP-43 is found in the nucleus, said first author Armakola. But in the diseased cells, it aggregates in the cyto- plasm and forms clumps. We developed a novel way to track where these lariats go in living cells, and we saw that when Dbr1 is missing, the lariats act as a sink to sequester TDP-43. The researchers note that it s still not entirely clear whether the cells die because the mutant TDP43 is drawing essential RNA transcripts or regulatory molecules away from the nucleus and into the cytoplasm, or because it s not performing its normal RNA-binding function in the nucleus. Both could contribute to the progression of the disease. 115 E. Main St. - Warrenton, MO Family Owned & Operated - Weekly Gun Raffle Tuesday - Saturday 9:00-6:00 Open late on Thursdays Snow Removal Leaf Removal Gutters Cleaned Laminate Floors Driveway Sealing Pu/Del Services Lawncare Handyman services Randy Pruning Blinds Hauling Painting Fencing Window Cleaning Lt. Plumbing Lt. Carpentry Lt. Electrical Ceiling Fans Tile Setting Power Washing Brush Hogging 10% Discounts to seniors 10% cash Discount Wentzville Shop Hop November 9th & 10th Beginning at 10 a.m. on Friday, November 9 and ending Saturday, November 10 at 4 p.m. Customers will obtain a passport with a map of business participants and receive a stamp at each location. e Lifetim e nte Guara Turning The gun World upside down! Handy Randy Participants may win gift certificates & prizes. Have a good time shopping, eating and checking out what each business has to offer. 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13 Obituaries Page THE FOCUS NEWS Friday, Novemeber 2, Regina F. Murray Regina F. Murray, of O'Fallon, MO, passed away on Tuesday, October 23, 2012 at Garden View Nursing Home in O'Fallon, MO, at the age of 101 years. Regina was born to John S. and Anna (nee Schauf) Farrell on January 19, 1911 in Wilson, KS. She was united in marriage to Matthew S. Murray, Jr., on July 30, 1935 in Kansas City, MO. He preceded her in death on December 26, They celebrated 50 years of marriage. She was a registered private duty nurse until she started her family. Survivors include five sons, John Murray (Carole) of Garland, TX; William "Bill" Murray (Cindy) of St. Peters, MO; Robert "Bob" Murray of Virginia; Bernie Murray (Debbie) of Florissant, MO; and Mike Murray (Barb) of Glendale, MO; three daughters, Patricia Gregas of Virginia; Mary Jane Thompson (Leonard) of Panama, IL; and Jeanie Ginther (Jim) of Warrenton, MO; one sister, Peg Haffamier of California; one daughter-in-law, Hiltraut Murray of Delaware; twenty-one grandchildren; nineteen great-grandchildren; other relatives and many friends. She was preceded in death by her parents; her husband; one son, Matthew S. Murray, III; one son-inlaw, George Gregas; and one sister, Bernardine Patterson. Visitation was held on Monday, October 29, 2012 from 9:00-10:00 a.m. at St. Ignatius Catholic Church in Concord Hill, MO, with a mass at 10:00 a.m. Burial was at Jefferson Barracks National Cemetery in St. Louis, MO. Memorials may be made to American Cancer Society or St. John's Hospice in care of Martin Funeral Home, 510 E. Main, Warrenton, MO Online condolences may be made to www. martinfuneral.net. Orval E. Seigler Orval E. "Rooster" Seigler of Winfield, MO, died on Friday, October 26, 2012 at the age of 80. He was born on November 14, He was the loving husband of Virginia Seigler (nee Ohlms), cherished son of the late James B. and the late Marie Seigler; loving father of Linda (Mark) Saettele; Richard (Sherry) Seigler and Donna (Scott) Vogt; adored grandfather of eight and great-grandfather of two. Orval is also survived by his siblings, James Seigler Jr., Virginia Sullivan, and Robert Seigler. He is preceded in death by his brother Roy Seigler. He was a proud member of Local 513 Operating Engineers, AM- VETS Post 106, VFW Post 4219, American Legion Post 312 and Trinity Lutheran Church in Troy, MO. Funeral services were held on Monday, October 29 at 10 a.m. at Family Owned and Operated. Serving LincoLn And Pike counties Funeral Home & Cremation Center Baue Funeral Home in St. Charles. Visitation was held on Sunday from 3 to 8 p.m. and on Monday from 9 a.m. to 10 a.m. at the funeral home. Burial was in St. Peter Cemetery in St. Charles. Memorials may be made to Trinity Lutheran Church in Troy, MO, VFW Post 4219, American Legion Post 312 or AMVETS Post 106. Donald Melvin Karrenbrock Donald Melvin Karrenbrock, age 79, of Warrenton, MO, died on October 24, 2012 at Mercy Hospital in Creve Coeur, MO. He was born on May 24, 1933 in Jonesburg, MO. He was a union carpenter. He is survived by two sons, Randy and wife Diane Karrenbrock of St. Peters, MO; Jeff and wife Kristina Karrenbrock of Town & Country; and five grandchildren. He was preceded in death by his parents, Henry and Della Karrenbrock (nee Nieman); his wife, Joyce Karrenbrock (nee Blake). Funeral services were held on Monday, October 29 at 10 a.m. at Pitman Funeral Home in Warrenton. Private burial was in Jonesburg City Cemetery in Jonesburg, MO. Memorial contributions may be made to Turning Point or American Diabetes Association in care of Pitman Funeral Home, 1545 Wentzville Pkwy., Wentzville, MO Mabel Cunningham Mabel K. Houf Cunningham, 93, of Montgomery City, MO, died on Wednesday, October 24, 2012, at the New Florence Nursing and Care Center in New Florence, MO. One of ten children, Mabel K. Houf Cunningham was born near Middletown, MO, on November 17, 1918 to Gordon Clare Houf and Thora Jeanette White Houf. Teaching was her lifelong passion. Upon graduating from Middletown High School, she received an offer to teach in a one-room school near Williamsburg, MO. She received teacher training at the College of the Ozarks (now the University of the Ozarks) in Clarksville, Arkansas from 1937 until While continuing to teach, she worked on a teaching degree, receiving a Bachelor of Science degree in education from the University of Missouri, Columbia, in Mabel taught elementary students for 44 years. Her first ten years were spent in Callaway County at High Point, Gregory, Williamsburg and Grant Schools. The remainder of her career was spent in Montgomery County at New Florence, Bellflower, and Jonesburg. Hundreds of fifth grade students have named Mrs. Cunningham as their teacher. Mabel married Herbert Hansen Cunningham in High Hill, MO, on December 31, 1944 and they FunerAL & cremation center (636) made their home in Montgomery City. Herbert preceded her in death on January 25, Mabel was a member of the Montgomery City Christian Church, as well as the Montgomery County Area Retired School Personnel Association. Following retirement, she and her husband were winter Texans for several years, living in the Harlingen area; they enjoyed square dancing in Texas as well as in their home community. Mabel was also a member of the Order of the Eastern Star #323 in Warrenton, MO. Preceding Mabel in death were her parents, her husband, brothers: William and Mabel Houf of Miller, MO; Sam, Leona, and Loretta Houf of Wichita, Kansas; Harry Houf of Wellsville, MO; Raymond and Joan Houf of Unionville, MO; and Henry Ford Houf of Middletown, MO; and sisters: Virginia and Barney Daniels of Aurora, MO; Evelyn and Rex Paris of Kansas City, MO; Cannie and Walter Christenson of Vandalia, MO; and Alice Garrett of St. Louis, MO; and brother-in-law, Berwyn McDannold of Mexico, MO. Surviving are her sister, Ruth McDannold of Mexico, MO; sisterin-law, Betty Houf of Mexico, MO; and many nieces and nephews including: Robert and Karen Houf of Unionville, MO, Herbert Ray and Brenda Houf of Unionville, MO and Judy Gail Houf Turner of Unionville, MO; William G. and Kathy Houf of Livermore, CA; Susan and Stuart Phelps of Canon City, CO; Dr. Ted and Gale Garrett of St. Louis, MO; Kathy (Garrett) and David Moros of Suffolk, VA; Gary Heim and wife, Janet, of Middletown, MO; Mary Ann Hensley and Melvin Asay of Pocatello, Idaho; Karen Rex (Paris) and Tom DeWitt of Wichita, KS; Gordon B. and Jane Houf of Mexico, MO; Jim and Lilly Houf of Wellsville, MO, and Danny Houf of Wellsville, MO; Steve and Marti McDannold of Rocky Mount, MO; and Diana (McDannold) and Fred Norman of Tipton, MO. Funeral services were held at 2:00 p.m. on Saturday, October 27, 2012, at the Schlanker Funeral Home in Montgomery City, MO. The Reverend Gary Bailey will officiate and interment will be in the Fairmount Cemetery in Middletown, MO. Visitation will be held from noon until the time of service on Saturday at the Schlanker Funeral Home in Montgomery City, MO. In lieu of flowers, memorial contributions may be made to the student scholarship fund of the Montgomery County High School or the American Cancer Fund, c/o Schlanker Funeral Home, 207 Danville Road, Montgomery City, MO Condolences may be made to Vernon E. Schewe Vernon E. Schewe, age 79, of Lake Saint Louis, MO, died on October 25, He was born on December 1, 1932 in Jennings, MO. He was an industrial agri-engineer. He had participated in numerous Senior Olympic events across the United States and was five medals short of 1,000 upon his death. He served in the United States Army. He is survived by his wife, Margaret "Peggy" Schewe of Lake Saint Louis, MO; one son, Steven and wife Deanna Schewe of Alton, IL; two daughters, Pamela and husband Robert Cook of Ellisville, MO; Kerri Schewe and Chris Mileski of Wildwood, MO; two sisters, Marilyn Schewe of Atlanta, GA; and Karen and husband Dennis Dettro of FL; seven grandchildren; and three great-grandchildren. He was preceded in death by his parents, Edwin and Gladys Schewe. Funeral services were held on Tuesday, October 30 at 1:30 a.m. at Dardenne Prairie Church in Dardenne Prairie, MO. Burial was private. Memorial contributions may be made to Mercy Hospice in care of Pitman Funeral Home, 1545 Wentzville Pkwy., Wentzville, MO Donald Kell Bryant Donald Kell Bryant of Troy, MO, passed away quietly on Thursday, October 25, 2012, at 10:30 p.m. at the Troy Manor in Troy at the age of 93 years, 11 months and 25 days. The son of David Kell and Lillian (Wall) Bryant, he was born October 31, 1918, in Ray County, MO. He was united in marriage to Dorothy Mae Vanskike on July 13, 1941, in Macon, MO, and she preceded him in death on March 25, Also preceding him were his parents; his wife, Dorothy; and a granddaughter, Abby Bryant. He is survived by two daughters, Donna Simpson and husband, Jerry of Troy, MO; and Bonnie Palmer and husband, Rich of Old Monroe, MO; one son, Larry Bryant of Columbia, Missouri; six grandchildren, Scott Simpson and wife, Kris, Lance Simpson and wife, Amber, Kelly Bone and husband, Kevin, Greg Palmer and wife, Michelle, Paula Palmer Berneking and husband, David, and Lynn Palmer Rogliardi and husband, Paul; fifteen great-grandchildren, Tyler and Morgan Simpson, Zach and Samantha Simpson, Drew Millar, Nolan and Reagan Bone, Brett, Alison and Avery Rogliardi, Brett, Palmer and Kell Berneking, and Laniey and Boden Palmer; and two sisters, Betty Ann Daniel and Jean Bengston of Richmond, MO. During WWII, Don served in the Navy from February, 1944 to December, 1945, serving in the South Pacific on the destroyer USS Case. During this time he was the ship s storekeeper. After the war, he became manager of Mattingly Brothers Store in Troy, from 1946 to his retirement in Don was a member of the United Methodist Church all of his life. In 1948 he was baptized at St. Stephens United Methodist Church. He was a charter member of Troy Kiwanis Club, which he joined in He served on the Troy School Board from 1957 to 1969, and as its president for 3 years. He was an active member of the Troy Chamber of Commerce. After retiring from Mattingly Bros., he worked as a hunting guide at Black Hawk Hunting Preserve in Old Monroe, MO. And he became a pretty fair golfer. Funeral services were held at 11:00 a.m., Monday, October 29, 2012 at the Ingersoll Chapel for Funeral and Cremation Services, Troy, MO. Visitation will was held from 9 a.m. until the time of the service Monday. Interment was in the Troy City Cemetery, Troy, MO. Memorial contributions may be made to the St. Stephens United Methodist Church. Honor the memory of Mr. Bryant at www. ingersollchapel.com. Through this site you may light a candle and share your fond memories with the family. Rev. Andrew Leo Beck Rev. Andrew Leo Beck, 93, of Elsberry, passed away on Friday, October 26, He was born on December 25, 1918 in Foss, Oklahoma. He was the son of Andrew Lee Beck and Nellie Ida Wheat. Leo attended and graduated from Burns Flat High School in Burns Flat, Oklahoma. During his senior year, he drove a school bus. On September 9, 1939, Leo married Maud Ellie Murphy in the Baptist parsonage in Dill City, Oklahoma. To this union, three children were born: Delores Diane, Donald Lee and James Noel. Leo was saved in 1943 in Riverview, Oklahoma. In 1947, Leo and family left the farm and entered into the ministry. He became a licensed pastor in the Bible Holiness Church and preached for approximately 50 years in the states of Missouri, Kansas and Illinois. The first place Leo pastored was Peace Valley, MO. He then moved to Vandalia, MO, and pastored part time at Bowling Green, MO. He then moved his family to New Florence, MO, Foley, MO, Kansas City, Kansas, South Pekin, Illinois, Middletown, MO, and the last church he pastored was Cherryvale, Kansas. Rev. Beck was also a carpenter during those years, remodeling several churches and parsonages as was needed. He loved doing work for God. He was an avid gardener. His pride and joy was his weed less garden and bountiful crops of popcorn and other vegetables. Leo worked in his garden until he could no longer work or see. After he retired, he and his wife, Ellie, moved to Elsberry, MO, where he lived for the past five years. Leo and Ellie had been married for over 72 years. Leo was preceded in death by his parents, his wife, Ellie, nine sisters and seven brothers. Leo is survived by his children, Diane Goins and husband Elbert of Thayer, Kansas; Don Beck and wife Suzy of Foley, MO; and James Beck and wife Sue of Troy, MO; nine grandchildren, nineteen great grandchildren and one great, great grandson; one brother, Jesse Beck and wife Gussie of Roswell, Georgia; two sisters-in-law, Essie Hendrix of Cordell, Oklahoma, and Jean Murphy Smith of Havana, Kansas ; one brother-in-law, Junior Murphy of Cordell, Oklahoma, and many nieces and nephews. Leo was a wonderful father and fun-loving, caring grandpa. He will be greatly missed by his family. His greatest desire was for an unbroken circle in Heaven! Visitation was held from 4-8 p.m. on Monday, October 29, 2012 from the McCoy-Blossom Funeral and Cremation Center, Troy, MO. Funeral services were held at 11 a.m. on Tuesday, October 30, 2012 at the McCoy-Blossom Funeral and

14 Obituaries Page THE FOCUS NEWS Friday, Novemeber 2, Cremation Center, Troy, Mo. Rev. George Prior, Rev. Gary Jackson and Rev, Jeffrey Gordon officiated. Interment was in Troy City Cemetery, Troy, MO. Memorials may be made to Gideons International in care of the funeral home. Homer Lee Avis Homer Lee Avis, of Warrenton, MO, passed away Thursday, October 25, 2012 peacefully at home at the age of 88 years. Homer was born to Bernard Henry Avis and Theresa Wilhelmine Leisetta (nee Sprick) on September 11, 1924 in St. Louis, MO. Homer served his country in the United States Army during WWII from April 1943 to January 1946, stationed in Shepton-Mallet, Somerset England and with the 62nd Quartermaster Base Depot in Verdun, France during the Ardennes and Rhineland Campaigns. He was a life long member of Frieden's United Church of Christ in Warrenton where hewas honored to serve as a deacon. Homer worked in the construction business for over 40 years and was a member of the United Brotherhood of Carpenters and Joiners of America Local He was partowner pf Hase Construction and later part-owner of County Builders, both in Warren County. Survivors include by his loving wife of 65 years, Marliyn (Benton), of Warrenton, MO; three sons, Ben Avis and wife, Becky, David Avis and wife, Phyllis, and Dale Avis and wife, Julie, all of Warrenton, MO; one daughter, Marilee Barry and husband, John, of Warrenton, MO; two sisters, Bernadine Cope and June Myers, both of Warrenton, MO; dear grandchildren and great grandchildren; and many relatives and friends. He was preceded in death by his parents, and one brother, Olen Louis Avis. Visitation was held on Monday, October 29, 2012 from 4:00-8:00 p.m. at Martin Funeral Home, Warrenton, MO. Funeral services were held on Tuesday, October 30 at 10:00 a.m. at Frieden's United Church of Christ in Warrenton, MO. Burialwas at the Warrenton City Cemetery in Warrenton, MO. Memorials can be made to Frienden's United Church of Christ in care of the funeral home. Online condolences may be made at www. martinfuneral.net. Peter Richard Orr Peter "Pete" Richard Orr, age 77 years, of Warrenton, MO, passed away Wednesday, October 24, 2012 at his home surrounded by his loving family. Pete was born to Warren Gregg and Dorothy (nee-compton) Orr on December 12, 1934 in Baltimore, MD. He was united in marriage to Darlene DeMarco on October 25, 1997 in New Melle, MO. They have been united in marriage for 15 years. Pete owned Orr Realty. He was a member of the Warrenton Rotary and the Coffee Clutch. He was a member of the Masonic Lodge in Wentzville, MO. He was in the Sports Hall of Fame at Webster Groves for Track and Field. Survivors include his loving wife, Darlene Orr, of Warrenton, MO; one son, Gregg Orr (Janice) of St. Louis, MO; grandson, Jeffery Orr; granddaughter, Cameryn Orr; two nephews, John Orr of Patterson, NJ and David Orr of Trenton, NJ; niece, Candice Orr of St. Louis, MO; brother and sisterin-law, Denny and Toni Maunder of Weatherford, TX; sister-in-law, Sharon Schneider of Gainesville, FL; other dear relatives and many dear friends. He was preceded in death by his parents, one son and one brother. Visitation was held on Sunday, October 28, 2012 from 4:00-8:00 p.m. at Martin Funeral Home in Warrenton, MO. Visitation was also held on Monday from 10:00-11:00 a.m., with funeral services following at St John's United Church of Christ in New Melle, MO. Burial followed at the Church Cemetery. Memorials may be made to St. Louis Children's Hospital in care of the funeral home. Online condolences may be given at Jesse Leonard Purvis Jesse "Len" Leonard Purvis, age 70, of Lake Saint Louis, MO, died on October 28, 2012 at his home. He was born on May 18, 1942 in Kirksville, MO. He was an executive, retired from ALDI & AWG in Kansas City. He loved golfing, traveling, and doing home improvements. He greatly enjoyed his grandchildren. He was a member of Wentzville United Methodist and a member of the Lake St. Louis Ambassadors. He is survived by his wife, Nancy Parvis of Lake Saint Louis, MO; two daughters, Tammy and husband Joe Brown of Lake Saint Louis, MO; Teresa and husband Jeff Harrison of Colorado Springs, CO; one sister, Louise Purvis Tama of IA; and five grandchildren. He was preceded in death by his parents, Jessie and Ruby Purvis (nee Burrus); one sister, Linda Purvis; and one grandson, Hunter Brown. Funeral services were held on Thursday, November 1 at 1 p.m. at Wentzville United Methodist Church. Visitation was held on Thursday from 11 a.m. to 1 p.m. at the church. In lieu of flowers, memorial contributions may be made to the Cardinal Glennon Children's Foundation in care of Pitman Funeral Home, 1545 Wentzville Pkwy., Wentzville, MO RoseMary Engemann RoseMary Engemann, of Marthasville, MO, passed away Friday, October 26, 2012 peacefully at home at the age of 82 years. RoseMary was born to Anthony and Anna (nee Mayer) Roehrig on October 25, 1930 in Augusta, MO. She was united in marriage to Herman A. Engemann on November 15, 1950 in Dutzow, MO. They celebrated 61 years of marriage. She was a wife, mother and homemaker. She was a member of St. Vincent DePaul Catholic Church, the Ladies' Sodality and the Quilters' Guild in Dutzow, MO. She was also a member of the Daniel Boone American Legion Post #180 Ladies' Auxillary in Marthasville, MO. Survivors include her dear husband, Herman Engemann, of Marthasville, MO; three sons, David Engemann and wife, Debbie, and John Engemann and wife, Julie, both of Marthasville, MO; and Carl Engemann and wife, Mechelle, of Loganville, GA; four daughters, Christine Harris and husband, Wayne, of Chicago, IL; Dolores Henderson of Tallahassee, FL; Teresa Volkerding and husband, Mike, and Jennifer Engemann, both of Marthasville, MO; one brother, Harold Roehrig and wife, Lois, of Augusta, MO; two sisters, Marian Roesner of Augusta, MO; and Doris Weber and husband, Melvin, of Washington, MO; one sister-in-law, Arlene Roehrig of Dutzow, MO; twelve grandchildren;?one greatgrandchild and many other relatives and friends. She was preceded in death by her parents;?son-in-law, Tim Henderson; and two brothers, Anthony "Sonny" Roehrig, Jr. and Frederick Roehrig. Visitation was held on Tuesday, October 30, 2012 from 4:00-8:00 p.m. at Lichtenberg Martin Funeral Home, Marthasville, MO. Funeral mass was held on Wednesday, October 31, 2012 at 10:00 a.m. at St. Vincent DePaul Catholic Church in Dutzow, MO, with burial in the Church Cemetery. Memorials may be made to St. Vincent DePaul Catholic Church, the School, Masses or Daniel Boone American Legion Post #180 in care of Martin Funeral Home, 510 E. Main, Warrenton, Mo Online condolences may be given at Nell Grimes Mrs. Nell (Caldwell) Grimes, 80 of Eolia, MO, passed away on Sunday, October 28, Nell was born on August 25, 1932, in Curryville, MO, the child of James H. Caldwell and Vera F. (Kafoury) Caldwell. Nell grew up with three sisters and one brother, and family was always important to her. She attended the local schools and graduated from high school. In January 1952, she married the love of her life, Thomas J. Grimes, in Bowling Green, MO. Nell and Thomas were blessed with two sons; Donald, and Gary, and one daughter; Beverly. She truly was a doting mother to her children and dedicated wife to her husband. Nell truly enjoyed her role as caregiver. She stayed busy spending time with her family and friends and was an active member of her church. Nell was a kind and loving woman who touched the hearts of many. Nell was predeceased by her husband of 53 years. She is survived by her children: Donald E. Grimes and his wife Carole of St. Bruno, Quebec, Canada; Beverly F. (Grimes) Thompson and her husband Darrell of Columbia City, Indiana; and Gary T. Grimes and his wife Cynthia of Bear, Delaware; eight grandchildren; siblings, James H. Caldwell II and his wife Jeri of Seattle, WA; Isabell Watkins of Eugene, OR; Helen Caldwell of Springfield, MO; Emily Ogden and her husband Ray Ogden of Bowling Green, MO; many other relatives and friends. Visitation will be held on Sunday, Nov. 4, 2012, from 3:00 until 7:00 p.m at the McCoy-Blossom Funeral Home & Cremation Center in Troy, MO. A funeral service was held 10:00 a.m., Monday, November 5, 2012 at the Eolia United Methodist Church, 238 N. Main Street, Eolia, MO. Interment will follow in Eolia Cemetery, Eolia, MO. Memorials may be made to donor s choice c/o McCoy-Blossom Funeral Home & Cremation Center. Friends and family are invited to visit our website at to sign the on-line guest register. Charles Smith Charles Smith age 80, of Warrenton passed away Sunday, October 28 at St Joseph Hospital West in Lake Saint Louis, MO. Charles was born on August 11, 1932 to Thomas and Loraine Smith in Petersburg, IL. He was a former machinist working at many different companies throughout the St. Louis area. He enjoyed hunting, playing dominos and collecting many different things from flea markets. Charles is survived by his loving wife Wilma Joan; one son, Timothy Smith of Warrenton, MO; three daughters, Kimberly Clark and husband Scott of O'fallon, MO; Kathy Smith of Wright City, MO; Kerry Borders and husband Jerry of Troy, MO; five grandchildren, Kaylen, Matt, Dustin, Cammeron, Christine; and one great grandchild Ashlyn. A visitation was held on Thursday, November 1, 2012 from 4:00 p.m. to 8:00 p.m. at Martin Funeral Home in Warrenton, MO. Funeral Services will be held Friday, November 2, 2012 at 11:00 a.m. at St. Johns Lutheran Church in Warrenton, MO, with burial to follow at Mount Lebanon Cemetery in St. Ann, MO. Donations can be made to the American Heart Association c/o Martin Funeral Home 510 East Main Street Warrenton, Mo The Smith family has entrusted Martin Funeral Home to care for Charles Smith. Patricia Ann Tollefsrud Patricia "Pat" Ann Tollefsrud, 59 of Elsberry, MO, passed away on Monday, October 29, 2012 at her residence. She was born on July 29, 1953 in Jefferson City, MO, the child of Dale E. and Frieda R. (Schmidt) Wolf. She always loved to play any kind of sports activity, and enjoyed being outside. Pat was always a hard worker, and was a people person. She never met a stranger FUNERAL & CREMATION SERVICES and made friends wherever she went. Pat and her husband Wayne were inseparable and were together 24/7. For many years the couple owned and operated O Fallon Tap in O Fallon, MO. They spent a lot of time on the Mississippi River where they had a vacation home. Pat loved the river and was a self proclaimed river rat. She was a kind, caring individual who touched the hearts of many and will be missed greatly by all those who knew her. She is survived by her husband of 18 years, Wayne Tollefsrud of Elsberry; one son, Richard Allen of O Fallon; one daughter, Jody Allen of O Fallon; a step-son, Rick Tollefsrud of Lake St. Louis; one very special granddaughter, Alexis Lexi Gilpen of O Fallon; and many other relatives and friends. She is preceded in death by her parents. Funeral services are private per her request. Memorial contributions may be made to Heartland Hospice c/o McCoy-Blossom Funeral Home & Cremation Center, 1304 Boone Street, Troy, MO Friends and family members are invited to visit to sign the on-line guest register. Albert George Hannibal Albert George Hannibal, age 83, of Dardenne Prairie, MO, died on October 29, 2012 at 10:15 p.m. at his home. He was born on February 7, 1929 in St. Louis, MO. He was an executive at McGraw Hill Book Publishing and spent his early work years with McDonnell Douglas. Funeral services will be held on Saturday, November 3 at 10 a.m. at Sunrise Methodist Church in Dardenne Prairie. Visitation will be held on Friday from 4 to 8 p.m. at Pitman Funeral Home in Wentzville and on Saturday from 9:00 a.m. to 10:00 a.m. at the church. Burial was in Forever Bellerive in Creve Coeur. He is survived by three sons, Gregg and wife Christine Hannibal; Pat and wife Mary Hannibal; Bob and wife Debby Schroeder of Wentzville, MO; three daughters, Chris and Elaine Hannibal of Boston, MA; Peggy Hannibal; Cindy and husband Gary Casper; fiancee, Polly Samuel of Wentzville, MO; 16 grandchildren; and five greatgrandchildren. ADVANCED FUNERAL PLANNING BANQUET FACILITY CHILDREN S PLAYROOM 211 Boone Street Troy, MO CARE

15 News Page He was preceded in death by his parents, George Albert Hannibal and Emma Schultz; his wife, Florence R. Kettenacker; and one son, Jerry Hannibal. Memorial contributions may be made to the Sunrise UMC or the Green Lantern Senior Center in care of Pitman Funeral Home, 1545 Wentzville Pkwy., Wentzville, MO Steven Lynn Mount Steven Lynn Mount, 55, of Wright City, MO, passed away Monday, October 29, 2012 at St. Lukes Hospital in Chesterfield, MO, from injuries he received in an automobile accident on August 9, The son of Mountie and Phyllis Darlene (Wells) Mount, he was born August 8, 1957 in Louisville, Kentucky. He was preceded in death by: his mother; one brother, Michael Mount; and his step-father, Kermit Thompson. He is survived by: his father, Mountie Mount and his wife, Jeanette; his fiance, Angela Duff of the home; two daughters, Amber Poole and her husband, Dennis of Moscow Mills, MO; and Shelby Mount of Troy, MO; one son, Josh Mount and wife, Jennifer of Moscow Mills, MO; six grandchildren, Chad Poole, Riley Mount, Joshua Michael Mount, Jezeca Poole, Jayla Poole and Starla Poole. Mr. Mount was a 20 year employee of MEMC, St. Peters, MO. He loved Harleys, hunting, fishing boating and exploring creeks. He was a member of Sulphur Lick Baptist Church, Troy, MO. Cremation rites were accorded and a Celebration of Life was held at 2:00 p.m., Friday, November 2, 2012 at Ingersoll Chapel for Funeral and Cremation Services, 211 Boone Street, Troy, Missouri Honor the memory of Mr. Mount at Through this site you may light a candle and share your fond memories with the family. Mildred Edwards Coker Mildred (Emelia) Edwards Coker, age 94, of Lake Saint Louis, MO, died on October 29, 2012 at St. Joseph Hospital West in Lake Saint Louis, MO. She was born on February 25, 1918 in St. Louis, MO. She was self-employed, doing embroidery and monograms. She is survived by two daughters, Donna Gill of Lake Saint Louis, MO; Darlene Griswald of Wentzville, MO; three sisters, Vera Trebilcock of Overland, MO; Helen Thacker of CA; and Elizabeth Schneider; and six grandchildren. She was preceded in death by her parents, Walter and Catherine Krynski (nee Lesinski); her husband, Verl E. Coker; and four sisters, Lottie Kuleza, Ann Gann, Julia Vago, and Marian Romero. Funeral services will be held on Friday, November 2 at 12 p.m. at Immaculate Conception Church in Dardenne Prairie, MO. Visitation will be held on Friday from 11 a.m. to 12 p.m. at the church. Burial will be in Oak Grove Cemetery in St. Ann, MO. Memorial contributions may be made to Church Masses in care of Pitman Funeral Home, 1545 Wentzville Pkwy., Wentzville, MO Allergy Compounds...CONTINUED FROM PAGE 6 separation of IgE from the FcRs on the surface of mast cells. But separating these dangerous couples is a tall order because their interaction is extremely stable sensitizing the mast cells for weeks. Currently available treatment using omalizumab (an anti-ige antibody sold under the trade name Xolair) can block new interactions between IgE and FcR, but it is not designed to pry the molecules apart once they ve formed a bond on the surface of a mast cell. So Xolair can dampen the allergic response, but as stated on the product s website: Xolair is not a rescue medicine and should not be used to treat sudden asthma attacks. While simply blocking IgE binding is helpful for some allergy sufferers, when it comes to the rapid quenching of an acute allergic response, what you d really like to do is get rid of it, said Jardetzky. Along with scientists at the University of Bern, his team discovered that an engineered protein inhibitor called DARPin E2-79 stripped IgE from the mast cell receptor. Using this inhibitor, an interaction that normally lasts for hours or days in terms of its stability is stripped off in a matter of seconds, said Jardetzky. DARPin E2-79 is one of a family of engineered inhibitors containing protein-binding regions called ankryin repeats. While Jardetzky s group was using structural biology and biophysical approaches to probe the weak spots in the IgE-FcR interaction, scientists at the University of Bern were tinkering with DARPins that dampened IgE s disastrous effects. The collaboration of the two groups resulted in the characterization of DAR- Pin E2-79, an inhibitor that goes beyond mere blockade to actively disassemble the IgE-FcR power couple. Jardetzky s group solved E2-79 S structure and used this information to model its interaction with the IgE-FcR pair. Then, using sensitive biochemical techniques that detect step-by-step binding interactions between molecules, the teams were able to tease out the Go BIG or Go Home! TKO-WASH Hours: 5 a.m. to 11 p.m. (877) 856-wash MONTGOMERY WENTZVILLE CITY 707 W. Pearce Next to Papa John s Pizza 200 Sturgeon St. mechanism that the inhibitor uses to break the IgE-FcR bond. The researchers found that E2-79 hastens the separation of the two molecules by taking advantage of a moment of weakness in the relationship between IgE and FcR. IgE maintains its interaction with FcR using two contact points, and occasionally one of these points releases while the other one keeps the pair together. Normally this brief looseness isn t enough to separate the couple, but E2-79 can swoop into the small space between them, effectively driving the couple apart. While E2-79 is the first molecule to display these IgE stripping characteristics, Jardetzky hopes that this work will stimulate the discovery of smaller compounds capable of working even more efficiently. Drug developers generally expect large macromolecules like E2-79 to be less potent than small molecule inhibitors and unlikely to be able to disrupt complexes, so the fact that E2-79 worked so well was a surprise. Small molecules are more amenable to oral administration, and are easier and cheaper to manufacture than large macromolecules. Now we re in the hunt for a small molecule that could have this kind of activity. That would be the real hit, said Jardetzky. The discovery of E2-79 s mechanism of IgE inhibition could lead to rapid discoveries from other labs as well. Now that scientists know what mechanism to look for, they may be inspired to dig back through freezers full of IgE inhibitors that were identified years ago, said Jardetzky. In the light of techniques described in this study, perhaps once-neglected inhibitors will show new promise in the treatment of allergic disease. The study was funded by the National Institutes of Health, the American Asthma Foundation and the Swiss National Science Foundation. Information about Stanford s Department of Structural Biology, which also supported the work, is available at structuralbio.stanford.edu/. Tired of Spending All Day doing Laundry at Home? KNOCK IT OUT FAST at Crossroads Laundry Super Fast High-Extract Washing Machines The Biggest & the Best in the Tri-County Area! Do Your Laundry in an Hour in Our State-of-the-Art Facilities WARRENTON 1319 Green Acres Center Next to Domino s Pizza THE FOCUS NEWS Friday, Novemeber 2, 2012 How is the movement of life for you? Right now is your life moving at a speed beyond your control? I ve noted as I get older, mentioning this in other articles, the perception that time moves much quicker as I get older and seems to be the norm of my here and now. When I was young I used to hear the adults convey this very sentiment and in hearing this I as a youngster often could not understand this concept feeling held back and stagnant and in holding mode waiting for my life to begin. In my early twenties, if it wasn t one thing (mainly money) or another (lack of money) keeping me from doing or accomplishing this (my hearts desires) or that (the ability to go after my hearts desires) I became determined to take time into my own hands and force things to happen. Now- well into my 40 s- there is more to do than I have time for, with nary a moment to slow down unless forced to. Ah, such as the naivety of youth! Recently I was talking with a friend of mine asking her what would be a good topic for this week s article. It was the flavor of this very same prior stated sentiment on the lack of time with which she spoke of too, and not just in her own life. In her line of work she hears what is on women s hearts; women of many differing ages and generations. She and I are about the same age and she said she can remember taking a few moments to read through a magazine back when she was younger. Today, she is hard pressed to even have a moment to herself. I had to ask her if this lack of time is made by personal decisions that encompass her life or is she encumbered with things beyond her control that take up her time? After some discussion we both agreed that life today just holds more. We have more to do. We have more responsibility. We have more technology. We have so much more pulling us this way or that usually never in the direction of our hearts desires! The cost of living is so much higher, and the unrest of what is coming tomorrow just to be able to live is overwhelming us to work harder at all things. When she and I were young, women were just getting their Poetizing Life: R U the speed of Life? By: Heather Farrar 15 mainstay bearings in the workplace. Being a stay at home Mom was still a choice. Now, though, in this economy it takes two- sometimes more incomes- just to keep a hair above water. We also noted that the families in years past who may have shared the responsibility in caring for aging parents now seem to fall onto one person. This responsibility of it falling onto one person alone in a family may also be multiplied in caring for children in conjunction. This is a burden of the heart, true, but still a burden to one person. It is complicated when siblings cannot or will-not note their own connection to provide some form of relief or responsibility to their own. The answers for life s full throttled forward motion are few. The fact that it is sped up is reality. The truth is: time has accelerated with multiple acts for responsibilities given and chosen, and the choices that have grown out each one of these in all of our lives. I know that it is hard for one to say no in certain situations. I also know there have to be boundaries too-if only for the sake your own well being. Each of us is allotted a certain amount of time here on earth. For those moments: think clearly on what you will focus that time on. There are times in our life when no choice is given and we must endure through these times. Then, there are times when life gives us an abundance of things for which we can become inter-woven into. It is then that we must eloquently unravel one by one these strands that bind us and are not well suited for our substance at the time and we must let them go. I want to refer to one of Abraham Maslow s theories on selfactualization, Autonomy and solitude is characteristic of selfactualized people. These people feel the need for independence and privacy. While they enjoy the company of others, these individuals need time to focus on developing their own individual potential. There is little time for our many things in life, yet for us: what only truly counts is the right time for the many things that gives us life. or www. quillsongs.com why Does your ad in FoCus work? 1. Your success is our business 2. Only multi-demographic 6 county distribution weekly 3. Greater Reach = More Customers 4. Extremely Loyal Readership 5. Only newspaper that features your business on the Front Call Now!

16 A&E Page Saint Louis Art Museum Presents James Nares' Street in Gallery 301 The Saint Louis Art Museum presents its New Media Series installation, James Nares: Street, opening Friday, November 2. The 61-minute video will be on view in Gallery 301 through January 27, Using high-speed recording technology, Nares slows down footage of the busy streets of Manhattan and features pedestrians, commuters, and tourists who are largely unaware that they are being photographed. Their movements, presented in Street at a fraction of normal speed, reveal an array of experiences in each passing moment. After his move to New York in the 1970's, English-born Nares initially became known for his films, despite his practice of working across a variety of media. His paintings, which are frequently made from a single brush stroke, seek to capture the very moment of their creation while his films and videos focus on movement, rhythm and repetition. Nares further explores those themes in the video Street, which is set to hypnotic acoustic guitar accompaniment by Thurston Moore, of the band Sonic Youth. Nares' work has been featured in solo exhibitions at the Cine- Marfa Film Festival in Marfa, Tex. (2011), the Museo Reina Sofia, Madrid (2010), and the Anthology Film Archives, New York (2008). He also has been included in recent shows at the Tate Modern, London (2010), the Museum of Modern Art, New York (2009), the Albright-Knox Art Gallery, Buffalo, N.Y. (2005), and the Museum of Fine Arts, Boston (2005). James Nares: Street is curated by Tricia Y. Paik, assistant curator of modern and contemporary art. For more information, call or visit slam.org. Dine Out and Provide HOPE to the Underserved Community Event to raise money for Crider Health Center programs and services Crider Health Center is hosting its first Dining Out for HOPE event on Thursday, November 15. Funds raised by this event will help provide programs and services to the underserved communities of St. Charles, Lincoln, Warren and Franklin Counties who are uninsured, underinsured, or receiving Medicaid benefits. For one night, Crider Health Center has partnered with locallyowned restaurants that have generously agreed to donate 10% of their sales to help provide services such as integrated healthcare, community supports, and school-based programming to individuals and families in the community who need it most. "We are excited to be partnering with locally-owned restaurants in the community to provide residents with a flavorful opportunity to give back to their community," said Pamela Imboden, Marketing and Development Associate for Crider Health Center. "By taking part in the Dining Out for Hope event, the community as a whole will be providing hope for underprivileged children, adults and families who need help finding access to quality, affordable healthcare. And they can help their community by simply doing something they already do - enjoying a night out with their families and friends." Several restaurants across the area have already made a commitment to participate, offering the community a wide variety of cuisine to choose from. Presently, nine restaurants, including The Brass Rail, Grappa Grill, Pantera's Pizza, Rendezvous Cafe and Wine Bar, and Rib City in St. Charles County; Cedar Lake Cellar, Hillbilly Heaven, and Two Dudes Bar- B-Que in Warren County; and Green Pepper in Lincoln County are confirmed to participate. "We fully anticipate adding more restaurants to this list so we encourage the community to visit our website at org frequently," said Imboden. Restaurants wishing to support this worthy cause are encouraged to call Sarah Javier at or Pam Imboden at for more information. More Traffic = More Money Drive More business to your store Advertise in The Focus Call Now! FRIDAY, NOVEMBER 2 Washington Art Walk from 4:00-8:00 p.m. Stroll through the downtown galleries and enjoy the works of Gary Lucy, Larry Pogue, Marty Coulter, Jim Peters, MMFAS, Noreen Baker, ARTCanDo, and ECC Student Artists in Ceramics, Drawing, Printmaking, and Photography. Spaghetti Dinner and Auction at Hawk Point Lions Club. Dinner/ Silent Auction at 4:30 p.m. Live auction at 7:00 p.m. supports Hawk Point Elementary School. Turkey Dinner at St. Stephen United Methodist Church in Troy from 4:00-7:00 p.m. Turkey & dressing, real mashed potatoes & gravy, old fashioned cooked green beans, cranberry salad, homemade tolls, fruit pies & cakes (and prepared cream pies), coffee, tea and lemonade. Carry-outs available. Powell Memorial Library Used Book Sale at Bonfils Lobby in Troy from 12:00-6:00 p.m. and Saturday from 9:00 a.m. to 1:00 p.m. FAM JAM: Free Family Night Out at Morning Star Church, 1600 Feise Road, Dardenne Prairie at 6:00 p.m. & 7:30 p.m. is designed to bring parents and kids together for an evening of entertainment. For 45-minutes, families engage in a live production packed with highenergy music, drama, media, comedy and a look at the Good Book. Free and no need to register. Murder Mystery Dinner Theater at Pitman Banquet Center, Wentzville. Two shows, 6:30-10:00 p.m. Great show, amazing cast and fun "Trivia Night of the Living Dead" at O Fallon City Hall Gymnasium, 100 N. Main St. Doors open at 6:00 p.m., Trivia starts at 7:00 p.m. An evening full of brain power and brain eating with fun questions from a variety of categories, not just zombie trivia. Table of eight includes 10 rounds of trivia, door prizes, a mulligan, beer and soda; bring your favorite snacks and drinks. Cash prizes, 50/50, special games & drawings, prize for best decorated table and best costume plus silent auction. or SATURDAY, NOVEMBER 3 Oyster Supper at Smith Chapel UMC, 1866 Hwy CC in Elsberry from 4:00-7:00 p.m. Dance Marathon at Washington University Athletic Complex Field House in St. Louis from 2:00 p.m. until 2:00 a.m. tomorrow. In addition, there are games and craft activities suitable for the entire family, plus a silent auction. Faculty and Staff Reception, a special opportunity to learn more about Dance Marathon and hear from some of the Miracle children and their families begins at 4:00 p.m. Dance Marathon is an entirely student-run event that culminates yearlong fundraising efforts for Children s Miracle Network Hospitals of Greater St. Louis, benefiting St. Louis Children s Hospital and SSM Cardinal Glennon Children s Medical Center. Registration open until the event. Free Seasonal Flu Vaccinations at SSM Cardinal Glennon Children's Medical Center Ambulatory Care Clinics, 1465 South Grand Blvd. St. Louis 8:00 a.m. to noon. Ages six and above only. Information about the seasonal flu, the vaccine and the clinics at or Anti-Heroin Rally in Wentzville from noon until 3:00 p.m. Rally participants will be lined up along Wentzville Parkway, running north from near the intersection of Wentzville Parkway and Pearce Boulevard, wearing T-shirts and carrying signs and banners designed to bring awareness to the growing epidemic of heroin use among young people. Just show up that day and join with getting the message out on the rise in heroin use among teens, the death and destruction caused nationwide, and pay respects to the tens of thousands of young people lost to the heroin epidemic in recent years. Many participants display tributes in memory of someone they knew or loved who died of a heroin overdose. More information on Facebook: Anti-Heroin Rally Page St. Louis Region. Plowsharing Crafts Sale at St. Peter's UCC, 20 E. 5th St. in Washington from 8:30 a.m. to 3:00 p.m. and Sunday, 9:00 a.m. to noon. Turkey Supper at Friedens UCC, 980 Main Street, Moscow Mills from 3:00-7:00 p.m. Turkey, dressing, mashed potatoes, gravy, slaw, green beans, corn, homemade bread, pie or cake. Carry-outs available. Organic Gardening Class by Master Gardeners of Lincoln County from 10:00 a.m. to noon. Unravel the "mysteries" of organic gardening, learn how to be a green gardener. Registration deadline one week prior to class. for complete class details and directions to the extension office. Breakfast with the Doctor at Hilton Garden Inn St. Louis Airport, 4450 Evans Place, St. Louis from 8:30-10:30 a.m. Join SSM Orthopedics for an informative discussion on treatments for your knee and hip pain. Learn about the latest non-surgical and surgical procedures, including partial knee replacement. Here s your chance to understand your options when it comes to knee and hip replacement. Free, but space is limited; to register. Young People's Theater 5K Fun Run at 9:00 a.m. at St. Charles Community College, 4601 Mid Rivers Mall Drive in Cottleville features musical performances by YPT including sights and sounds of famous Broadway musicals performed during the run and while runners visit local vendors. Awards to the top three finishers in adult male & female, child male & female. Overall male and female winners crowned Drama King and Queen at 10:15 a.m. in the outdoor amphitheater , Gently Used Furniture Collection at Morning Star Church Furnishing Hope Trailer, Northwest corner of I-70/Hwy 79 from 10:00 a.m.- 4:00 p.m. The goal: to collect 150 pieces of furniture to those in need in the Joplin region. To schedule a pick up on/before Nov. 3, or Ham & Bean Dinner at Jonesburg Masonic Building from 11:00 a.m. to 2:00 p.m. Fall Festival at Community of Christ, 2790 Hwy K, O' Fallon. SUNDAY, NOVEMBER 4 (Daylight Saving Time Ends) THE FOCUS NEWS Friday, Novemeber 2, 2012 Events Calendar 16 Pork Sausage and Sauerkraut Dinner at Immanuel Lutheran Church, 214 W. 5th Street in Washington from 11:00 a.m.-6:00 p.m Drive 4 UR Community fundraising event by Pundmann Ford to benefit Sts. Joachim and Ann Care Service, Care Center parking lot, 4116 McClay Rd., St. Charles, 9:45 a.m. to 2 p.m. Participants can test-drive their choice of several Ford vehicles free. Ford will donate 20 per ride to help those in crisis and prevent homelessness and hunger. Everyone is invited to take the wheel and help impact thousands in our local communities , ext Service of Healing & Remembrance, Hawk Point Community Church, 322 Maple St., Hawk Point, 1:30 p.m. People who are in need of healing a longtime illness or who are grieving the loss of loved ones are invited to attend. To include special prayers for healing or remembrance of a loved one in the service, call the church at to leave the information the day before the service. There will also be time during the service for additional concerns to be named. Bobby Wallace Basketball Camp at Progress Park in Wentzville from 9:00-11:30 a.m. Nov. 4, 11, 18, Dec. 12 for ages Start with the fundamentals. Camp helps players develop skills in shooting, passing, dribbling and defense. Register at least one week in advance to insure minimum registration needed Craft Bazaar & Sausage Breakfast at Millwood Knights of Columbus Hall from 8:00 a.m. to Noon. Sausage, biscuits & gravy, pancakes, scrambled eggs, fruit, Danish, milk, coffee, juice. First Sunday Breakfast at St. Vincent Dining Hall, Dutzow from 7:30-11:30 a.m. Bacon, ham, sausage, scrambled eggs, biscuits & gravy, hash browns, pancakes, and cinnamon rolls. Grade school children free. MONDAY, NOVEMBER 5 Health Matters Luncheon at 101 Mockingbird Lane, Ste. 100, Warrenton from 12:00-1:00 p.m. Topic: The Benefits of Wellness Activities (massage, personal trainers, group exercise, yoga, range of motion). A healthy lunch will be served (3 donation suggested). RSVP by Nov. 1 at or Healthy Meal Replacement Program Orientation at SSM DePaul Wellness Center Mondays 6:00-7:00 p.m. and Tuesdays Noon-1:00 p.m. in November. Attend a free orientation to learn the five success variables needed to lose weight, different diet options available and how important physical activity really is. Register at Mother to Mother at Barnes-Jewish St. Peters Hospital, Conference Room A/B (main hospital entrance A) from 6:00-7:30 p.m. 1st & 3rd Mondays for women experiencing postpartum or pregnancy adjustment issues. Infants (birth-12 months) welcome prior to attending first time. Look Good, Feel Better at Siteman Cancer Center at Barnes-Jewish St. Peters Hospital, 150 Entrance Way from 10:00 a.m. to noon November 5, December 3. This American Cancer Society program is designed to help women undergoing cancer treatment learn to cope with the appearance-related side effects of treatment and regain a sense of self-confidence and control over their lives to register. Sharing Losses Through Bereavement at SSM Home Care & Hospice, 1187 Corporate Lake Drive from 1:00-2:30 p.m. provides a supportive group setting to discuss the process of grief, identify and cope with emotions such as emptiness, loneliness, anger and guilt. 1st & 3rd Mondays. To register, TUESDAY, NOVEMBER 6 (Election Day) Knee Replacement Class at May Center Room A, SSM DePaul Health Center at 6:00 p.m to register or for more information. Stroke Support Group at May Center, SSM DePaul Health Center from 1:00-3:00 p.m. A presentation and educational session for stroke survivors and their family members or caregivers I-70 Trikers Chapter of Brothers of the Wheel Meeting at Pit Stop Bar & Grill, Hwy 19, Montgomery City at 6:00 p.m. 1st Tuesdays is looking for new members so if you ride a trike or bike, join them. Not a religious, political, or military group, just people who like to have fun and ride. or Childbirth Education Classes at Mercy Hospital, 901 E. Fifth St. in Washington 6:30-9:30 p.m. for four weeks starting 1st Tuesdays except December. Prepare for the birth process by learning relaxation techniques including breathing, massage, movement and positioning. Expectant moms should begin attending classes by the seventh month of pregnancy to register. WEDNESDAY, NOVEMBER 7 Free Health Talk Dinner at Spiro's Restaurant, 2275 Bluestone at 6:15 p.m. How "Over the Counter" Drugs Could Kill You, #1 Cause of Preventable Death, The Secret to Incredible Health, and How to Live Longer and Enjoy Life More Recycled Fashion at Progress Park, Wentzville from 7:15-8:15 p.m. for ages Make and add some items that no one will even recognize as a recycled item. You will be the trendiest person your friends know when they discover that you could make these things from items that you would normally throw away and instead you found a way to repurpose them Infant Care Class at SSM DePaul Health Center at 6:30 p.m. Topics: bathing, feeding, nutrition, taking temperatures, immunizations, growth and development. 15 per couple to register. Adjustable Gastric Banding Group at May Center, SSM DePaul Health Center from 5:30-7:00 p.m for information, ssmweightloss.com for updates or cancellations of meetings. Dinner with the Doctors at May Center, SSM DePaul Health Center from 6:00-7:30 p.m. Are chronic digestive problems interfering with your life? Know your options! Join two of the area s leading experts in the field of gastroenterology for a complimentary dinner and discussion. Learn about the latest advances in treating and curing digestive problems including minimally-invasive and robotic-assisted surgery. Free, space is limited: to register.

17 A&E Events Calendar Xeriscaping I Class at University of Missouri Extension,, 880 West College, Troy from 6:30-8:30 p.m. Wonder what to do after the summer drought of 2012? Learn the systematic concept for saving water in your landscape design. Registration deadline one week prior to class. for details and directions. Recycled Fashion at Progress Park Center in Wentzville from 7:15-8:15 p.m. for ages 6-8, 6:00-7:00 p.m. for ages Use items you would normally throw away and create trendy fashion items. Pre-register at least one week in advance to insure the program as minimum registration needed Hip Hop Dance at Progress Park in Wentzville 4:30-5:00 p.m. Nov. 7-Dec. 12 for ages Learn to dance like the pros! It is the most current of dance styles making a home in the dance industry. Pre-register at least one week in advance to insure the program as minimum registration is needed Breast-Feeding Basics at Barnes-Jewish St. Peters Hospital, OB classroom from 7:00-9:30 p.m or Registration required. Behavior and Communication for Caregivers at Kathryn Linnemann Library, 2323 Elm Street, St. Charles from 6:00-8:00 p.m or Registration required. First Aid for Grandparents at Kathryn Linnemann Library, 2323 Elm Street, St. Charles from 10:00-11:30 a.m or Registration required. Preparing for Your Total Joint Replacement at Progress West Medical Plaza, 2630 Hwy. K, O Fallon 10:00 a.m.-noon or Registration required. Showcase on Seniors at St. Peters City Center, One St. Peters Centre Blvd., St. Peters from 1:30-3:00 p.m. 1st Wednesdays for men and women 60+ focuses on improving physical, intellectual, social, cultural and financial interests Ready, Set Move at HealthWise Department, Barnes-Jewish St. Peters Hospital, 10 Hospital Dr., St. Peters Wednesdays through December 12, 10:30-11:30 a.m or Registration required. Yoga for Cancer Patients at Institute for Health Education, 222 S. Woods Mill Road, Chesterfield from 6:00-7:00 p.m. Wednesdays. Free , TLC Kid's Circle at Trinity Lutheran Church, 1307 W Boone Street in Troy from 5:007:00 p.m. for children age 3-grade 6. Bible lesson, music, arts and crafts, light meal Wednesdays through mid-april, Free THURSDAY, NOVEMBER 8 Career Planning and Admission Workshops by Pike-Lincoln Technical Center, Clopton School, Hwy WW from 1:00-3:00 p.m. is designed to provide applicants with information about career interests and aptitudes and financial aid. Classes: Administrative Business Technology, Medical Office Specialist, Digital Design, Computer and Networking Technology, Paramedic, Practical Nursing ( ), EMT-B, Diesel Mechanics, Auto Services, Auto Collision , or Ask Questions about Hormone Replacement at Barnes-Jewish St. Peters Hospital Conference Room A/B from Noon-1:00 p.m. with Joseph Hill, DO, gynecology, BJC Medical Group includes lunch. Registration required: Celtic Thunder Voyage at the Fox Theater in St. Louis at 7:30 p.m. pays homage to the musical culture of Ireland while exploring the musical journey each soloist has undertaken since the beginning of Celtic Thunder four years ago. WomenHeart of St. Charles County in the HealthWise Center Cardiology Center (hospital entrance B), Suite 117, Professional Building I, 6 Jungermann Circle in St. Peters from 6:30-7:30 p.m. 2nd Thursdays is dedicated to promoting women s heart health through advocacy, education and patient support. Pilates at WingHaven Medical Building, Suite 80, 5551 WingHaven Blvd., O'Fallon from 7:00-8:00 p.m. Thursdays , FRIDAY, NOVEMBER 9 ABLE Trivia Night at St. Charles Elk Lodge #690, 560 St. Peters Howell Rd. from 6:3011:00 p.m. St. Charles County Alliance for Business, Learning, and Education (ABLE) and local business leaders and school district personnel fosters workforce readiness and educational programs for K-12 students in our community. Registration fee includes beer, soda and coffee. Feel free to bring your own snacks but no outside alcoholic beverages, a cash bar is also available. Must be 21 years or older to participate. There will be 10 rounds with bonus rounds, a 50/50, and a silent auction. The winning table will receive a prize. To register go to For more information call and ask for Tammie DeLosSantos. Barnes-Jewish St. Peters Hospital Auxiliary Extravaganza at 10 Hospital Way from 7:00 a.m. to 5:00 p.m. Many vendors for your shopping pleasure Pilobolus at Touhill Performing Arts Center tonight at 8:00 p.m., Saturday at 2:00 & 8:00 p.m. are doing mind-bending new collaborations with people like puppeteer Basil Twist, Grammy-winning rock band OK Go, lead writer Steven Banks of SpongeBob SquarePants, and even the robotics lab at MIT. Free Speaking of Dance talk in the Terrace Lobby beginning 45 minutes before the performance. Tickets at Dance St. Louis Box Office, 3547 Olive St. Louis, M-F 9:30 a.m. to 4:30 p.m. or pilobolus.org MOMSNext (Mothers of School-Aged Children) at Morning Star Church, 1600 Feise Road in Dardenne Prairie from 7:00-9:00 p.m. 2nd Fridays through the school year, an open, accepting place for moms of kids grades K-12 for authentic community, personal growth, practical help & spiritual hope. Mary Mary Go Get It Tour at The Fabulous Fox Theatre, St. Louis at 8:00 p.m. After 3 Grammy Awards, 2 American Music Awards, an NAACP Image Award and a BET Award, the "Mary Mary way" sounds just as fresh and innovative on the duo's sixth album, the aptly titled Something Big, which resonates with a fusion of sound and empowering messages. AARP Driver Safety Program at HealthWise Department at Barnes-Jewish St. Peters Hospital, 10 Hospital Dr., St. Peters from 9:00 a.m.-1:00 p.m or org. Registration required. Shrek: The Musical at Bezemes Family Theater Main Stage at Lindenwood University in St. Charles at 8:00 p.m. Based on the Oscar-winning DreamWorks film that started it all, this brings the hilarious story of everyone s favorite ogre to life on stage or LindenwoodCenter.com Oak Leaf Artist Guild Fall Art Show at St. Peters Cultural Arts Centre, 1 St. Peters Centre Blvd. (City Hall) through December 3 interprets the style or genre of famous artists from the Stone Age to the Renaissance to Impressionism to Postmodernism. Free or "The Velvet Years : Warhol's Factory" at Foundry Art Centre, 520 N. Main Center, St. Charles from 10:00 a.m. to 5:00 p.m. through December photographs depict Andy Warhol s studio, the Factory, when he was emerging as a prominent visual artist and avant-garde filmmaker. foundryartcentre.org. To list your event, THE FOCUS NEWS Friday, Novemeber 2, 2012 Page 17 Saint Louis Art Museum Presents Federico Barocci: Renaissance Master The Saint Louis Art Museum is now presenting Federico Barocci: Renaissance Master. The international exhibition which opened on October 21 showcases a trove of exceptionally beautiful paintings and studies, the majority of which have never before been seen in this country, gathered from more than 35 institutions worldwide. Federico Barocci was one of the most innovative Italian artists of the second half of the 16th century and was highly sought after by both religious and secular patrons. A major influence on European masters hrissuch as Peter Paul Rubens, Barocci's art combines the beauty of the High Renaissance and the dynamism of the Baroque. In addition to his refined paintings, Barocci completed thousands of preparatory studies (over 1,500 survive), include pastel drawings and oil sketches - a technique he pioneered. Curated in St. Louis by Judith W. Mann, curator of European art to 1800, and Babette Bohn, profes- sor of art history at Texas Christian University in Fort Worth, Federico Barocci: Renaissance Master offers visitors a unique opportunity to study and understand a master's artistic process. The exhibition features a range of Barocci's best works from enchanting pastel and chalk studies to truly exceptional and breathtaking paintings. An international symposium will be held January 10-12, 2013, featuring exhibition curators Judith W. Mann, Babette Bohn,, and Carol Plazzotta of the National Gallery, London, as well as an international panel of scholars. A keynote address will be given by David Ekserdjian, Professor of the History of the Art and Film at the University of Leicester. Following its presentation at the Saint Louis Art Museum, Federico Barocci: Renaissance Master will travel to The National Gallery, where it will be on display from February 27 to May 19, Federico Barocci, Renaissance Master has been organized by the International Genomics ing Puerto Ricans, Colombians, African Americans and Mexican Americans during the analysis of data from the pilot phase of the project that focused on Asia, Europe and Africa. We felt it was very important to include these traditionally underserved populations, said Bustamante, noting that disease incidence can vary widely among what appear to be similar groups. As one example, he pointed out that collaborator Esteban Burchard, MD, professor of biopharmaceutical sciences and medicine at University of California-San Francisco, has shown that Puerto Ricans have a high incidence of asthma, while Mexicans have a low incidence. Normally we would think of both these groups as Hispanic, but they are on the extreme ends of the asthma spectrum, Bustamante said. Similarly, African Americans have a much higher incidence than white Americans of certain kidney diseases and diabetes. Now we can begin to delve deeply into the genetic causes of disease. Bustamante led a working group of the 1,0000 Genomes Project that developed computer algorithms to study a genetic phenomenon called admixing in which two or more formerly separate populations begin to mix. They combined the results of multiple algorithms that allow a deconstruction of an individual s ancestry based on recent genetic contributions. They ve termed the technique ancestry deconvolution. We can see where an individual might have recent European ancestry versus African ancestry, said Bustamante. The new study builds upon the 2010 results of the 1,000 Genome Pilot Project, which sequenced the whole genomes of 179 people in an attempt to identify all variations that occurred in at least 1 percent of the group. The new data in this Saint Louis Art Museum in association with the National Gallery, London, in collaboration with the Soprintendenza per il Patrionio Storico, Artistico ed Etnoantropologico delle Marche - Urbino and the Polo Museale Fiorentino, Gabinetto Disegni e Stampe degli Uffizi, Florence, and with generous support of the Kupferstichkabinett, Staatliche Museum zu Berlin. The presentation of Federico Barocci: Renaissance Master is supported by BMO Private Bank. The exhibition and symposium in St. Louis are supported in part by Sotheby's. Financial assistance has been provided by the Missouri Arts Council, a state agency. This exhibition is supported in part by an award from the National Endowment for the Arts. Additional support has been provided by Emerson. Admission to the Saint Louis Art Museum is free to all every day. For more information about the Saint Louis Art Museum, call or visit slam.org....continued FROM PAGE 6 study provides a more comprehensive examination of such so-called rare variants by combing lowcoverage whole-genome sequencing (in which every nucleotide is sequenced only about five times, as compared to up to 100 times in high-coverage studies) with more in-depth analysis of specific portions of the genome. Like many of the other researchers in the project, Bustamante and his colleagues plan to continue their participation in the effort. For the next phase, the 1,000 Genomes Project has collected and is sequencing DNA samples from Peru and Barbados, said Bustamante. This is a really important collection, and it will provide many additional resources for other research groups. In addition to Bustamante, other Stanford researchers who participated in the study include postdoctoral scholars Jake Byrnes, PhD (now at Ancestry.com), Simon Gravel, PhD, Eimear Kenny, PhD, Jeffrey Kidd, PhD (now at the University of Michigan), and Andres Moreno-Estrada, MD, PhD; research associate Phil Lacroute, PhD (now at Natera); graduate student Brian Maples; and former graduate student Fouad Zakharia, PhD (now at Citibank). The 1,000 Genomes Project is funded by multiple sources throughout the United States and internationally. Bustamante s portion of the work was funded by a grant from the National Human Genome Research Institute to him and his collaborators at Cornell University to develop methods for analyzing data from the project. Create a Distinctive Setting for Your thanksgiving Dinner with Ceramics Your Source for Clay & Ceramic Supplies Car-jo ceramics 321 Monroe Street, troy, Mo

18 News Diet Helps Women CONTINUED FROM PAGE 7 would make the day-to-day experience positive while not requiring overwhelming amounts of effort. For the study, 267 overweight/ obese women were randomized into one of two groups. The women in the control group immediately began taking part in a 20-week behavioral weight-loss program that encouraged greater intake of vegetables and fruit, increased physical activity and use of proven dieting strategies, such as keeping daily food records. The women attended weekly 90-minute sessions with a group facilitator to learn problem-solving skills aimed at losing weight. At the end of 20 weeks, they spent eight weeks using a similar problem-solving approach to learn weight-maintenance skills. By contrast, the women in the maintenance-first group spent the initial eight weeks learning the stability skills Kiernan s group had developed. The women were asked not to lose any weight during that time; if they did lose a few pounds, they were asked to gain them back. Kiernan said this skill mimics a more real-world approach for maintaining weight within a range of a few pounds, rather than aiming for a single number on the scale. After the eight weeks were up, the women embarked on the same 20-week weight-loss program as the women in the control group. After both groups completed their 28-week programs, Kiernan said the results showed that the women on average lost a similar amount of weight about 17 pounds, or roughly 9 percent of their initial weight. Once the weekly group sessions stopped, the women were on their own for the following year. We scheduled the weekly sessions to end in October so that the women would have to navigate the holidays by themselves, without any guidance from the group facilitators, said Kiernan, the principal investigator for the study. We wanted this to mirror real-life conditions as much as possible. When the women were weighed one year later after no contact with their group facilitators, Kiernan said she and her col- laborators were pleased to see that the maintenance-first women had regained only 3 pounds on average, compared to a 7-pound average gain for the control group. She added that the 3-pound gain falls squarely within the personalized range that the women were taught to use. Additionally, 33 percent of the women in the maintenancefirst group displayed what the researchers categorize as a favorable pattern that is, losing at least 5 percent of their body weight without regaining more than 5 pounds over the course of a year compared with 18 percent of the women in the control group. Kiernan said the maintenancefirst approach, though sounding a bit unorthodox, could be a useful tool for those who are trying to slim down and be healthier. This approach helps people learn how to make small, quick adjustments that can help them maintain their weight without requiring a lot of effort, she said. In the future, she hopes to further test the approach to see if people are able to maintain the weight loss for more than a year, and would also like to test it in larger, more diverse populations including men. She also noted that the initial study did not recruit any participants who had reported binge-eating behaviors, and so researchers would need to determine whether the maintenance-first skills were viable for vulnerable subgroups of people. Kiernan s Stanford co-authors include Susan Brown, PhD, a for- mer postdoctoral scholar; former research assistants Danielle Schoffman and Katherine Lee, MS; Abby King, PhD, professor of health research and policy and of medicine; C. Barr Taylor, MD, professor of Drivers: Dedicated Top Paying Runs! Consistent Freight, Weekly Home-Time for Solo's & Teams. Werner Enterprises: Drivers: Want a Professional Career? Haul Flatbed/OD Loads for Trinity Logistics Group! Earn cpm! CDL-A w/2yrs Exp. EEO/AA Call: psychiatry and behavioral sciences; and statistician Nina Schleicher, PhD. The senior author is Michael Perri, PhD, dean of the College of Public Health & Health Professions at the University of Florida. Page 18 The study was funded by the National Institutes of Health. Information about Stanford s Department of Medicine, which also supported the work, is available at real estate Preowned Double 17,900 Wont last! Doublewide on Lake Near Warrenton For Sale in Senior Mobile Home Park with 25 acre lake on culde-sac.view of lake from inlet to dam. Home is 24 x 36 with 2 Bedrooms, 2 full baths, 3 ceiling fans, 10 x 20 porch that has 3,500 in new insulated windows & door. Large shed, gas BBQ grill, siding, roof and carport 10 yrs. old, many flowers & shade trees. 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20 2 FOR 1 2 FOR 1 Electing Chris Kunza Mennemeyer Electing Chris Kunza Mennemeyer gives gives you you the service of of BOTH BOTH Kunza Mennemeyer AND Burkemper!!! Kunza Mennemeyer AND Burkemper!!! I support FOR HOW? our Veterans, and... 1 I am ready to be your Judge If elected in November, Burkemper moves to position of Circuit Judge, which creates a VACANCY in his current Judge position. That vacancy will be filled by the Governor APPOINTING a replacement - not by your vote. HOW? Burkemper is already a Judge until January 1, He will continue to serve you as Judge REGARDLESS of this 2012 Election. pport our Veterans, and... kemper is already a Judge until January 1, He will continue to serve you as Judge REGARDLESS of this 2012 Electio If elected He in November, will continue Burkemper to moves serve to position you as of Judge Circuit Judge, regardless which creates a VACANCY of this in 2012 his current election. Judge position. If elected in That November, vacancy Burkemper will be filled moves by the to Governor position APPOINTING of Circuit Judge, a replacement which creates - not a VaCanCy by your vote. in his current Judge position. That vacancy will be filled by the Governor appointing a replacement - not by your vote. A VOTE FOR KUNZA MENNEMEYER IS A WIN - WIN Small Business Owner for over 10 years Rotary Club ell-rounded Pro-Life Attorney Background: is A win-win more than 15 years Troy Chamber of Commerce HOW? all Business Buchanan Owner High for School over Co-Valedictorian 10 years Moscow Rotary Mills Chamber Club of Commerce MIZZOU Graduate with Honors Home & School Treasurer -Life Attorney more than 15 years HOW? I am ready to be your Judge Life Long Volunteer & Resident of Troy Lincoln County Bar Treasurer anuary hanan Experienced High 1, School He in will Co-Valedictorian over continue 20 areas of the serve Lawyou and as will Judge continue REGARDLESS improving those of programs. this 2012 Election. MO Family Law Executive Board ZZOU moves to Graduate Settled position over of with 2300 Circuit Cases Honors Judge, - Tried which over 500 creates You a VACANCY get the continued his efforts current of Judge Burkemper position. Sacred Home Heart & Church School Parishioner Treasurer e be Long filled Volunteer Former by the Assistant Governor & Resident Prosecuting APPOINTING of Troy Attorney i a support while I bring a fresh perspective and Professional Business Women I replacement all all court - not programs by your vote. currently in place, Proposed Legislation in Jefferson City exceptional experience in over 20 areas of the law. MO Assoc. of Drug Court Professionals HOW? I support all court programs currently in place, OR I am KUNZA 40 years old, I am MENNEMEYER a You Conservative get the continued Republican, efforts of Burkemper and I am asking for your vote. mer Assistant Prosecuting Attorney while i I bring bring a fresh a fresh perspective perspective and excep- and Professional Business Women 6/5/2012 3:41 PM posed Legislation I will make in better Jefferson use City of funds and resources we already have, while bringing common sense to our Court System, exceptional experience in over in over areas of of the law. IS A WIN says Kunza Mennemeyer. - WIN I give over ARTWORK 150 FOR hours APPROVAL of free PROOF legal 3 work to our circuit each year. CUSTOMER # : 5262 I am 40 years old, I am a Conservative Active Republican, Community Leader: and I am asking for your vote. s Active Community Leader: Rotary Club Well-Rounded Background: 6/5/2012 3:41 PM Rotary HOW? Club Troy Chamber Small of Commerce Business Owner for over 10 years n says Kunza Mennemeyer. I give over ARTWORK 150 Moscow FOR hours APPROVAL Mills of Chamber free PROOF legal 3 of Commerce Troy Chamber of Commerce work to our circuit each year. CUSTOMER # : 5262 Pro-Life Attorney more than 15 years Home & School Treasurer y Moscow Mills Chamber of Commerce Lincoln County Buchanan Bar Treasurer High School Co-Valedictorian I support all court programs currently in place, w and Home will continue & School improving Treasurer those programs. MO Family Law MIZZOU Executive Graduate Board with Honors 0 You Lincoln get the continued County efforts Bar Treasurer of Burkemper Sacred Heart Life Church Long Parishioner Volunteer & Resident of Troy while Professional Business Women MO I Family bring a Law fresh Executive perspective Board and Experienced in over 20 areas of the Law exceptional experience in over 20 areas of the law. 32 x MO 48 Double-sided Assoc. Corrugated of Plastic Drug Billboard Signs Court Professionals Imprint in Black Sacred Heart Church Parishioner Settled over 2300 Cases - Tried over 500 Disclaimer: a Conservative Professional Republican, Business Women and I am asking Former for your Assistant vote. Prosecuting Attorney Light grey line represents edge of sign and will not print. nd resources MO Assoc. we already of Drug have, while Court bringing Professionals 6/5/2012 3:41 PM common sense to Proposed our Court System, Legislation in Jefferson City THIS ARTWORK IS THE SOLE PROPERTY OF RUNANDWIN.COM. ANY REPRODUCTION OF ANY OR ALL OF THE ELEMENTS WITHIN THIS ARTWORK IS STRICTLY PROHIBITED. eyer. I give over ARTWORK 150 FOR hours APPROVAL of free PROOF legal 3 work to our circuit RUNANDWIN.COM each year. CUSTOMER # : 5262 I am 40 years old, I am a Conservative Republican, and I am asking for your vote. PO BOX 2096 * AIKEN, SOUTH CAROLINA * PH * FAX will make better use of funds and resources we already have, while bringing common sense to our Court System, 32 x 48 Double-sided Corrugated Plastic Billboard Signs Imprint in Black Disclaimer: of funds and resources THIS ARTWORK IS THE SOLE PROPERTY OF RUNANDWIN.COM. ANY REPRODUCTION OF ANY OR ALL OF THE RUNANDWIN.COM PO BOX 2096 * AIKEN, SOUTH CAROLINA * PH * FAX I am ready to be your Judg Burkemper is already a Judge until January 1, lecting Chris Kunza Mennemeyer gives you the service of BOTH nza Mennemeyer AND Burkemper!!! A Vote VOTE for FOR kunza KUNZA MENNEMEYER mennemeyer Well-Rounded Background: Active Community Leader: IS A WIN - WIN erienced in over 20 areas of the Law tled over 2300 Cases - Tried over 500 and will continue improving those those programs. you get the continued efforts of Burkemper I will make better use Light grey we line represents already edge of sign have, and will not print. while bringing common sense to our Court System, ELEMENTS WITHIN THIS ARTWORK IS STRICTLY PROHIBITED. says Kunza Mennemeyer. I give over 150 hours of free legal work to our circuit each year. Active Community Leader Troy Chamber of Commerce Moscow Mills Chamber of Commer Lincoln County Bar Treasurer MO Family Law Executive Board Sacred Heart Church Parishioner MO Assoc. of Drug Court Professiona 32 x 48 Double-sided Corrugated Plastic Billboard Signs Paid for by Kunza Mennemeyer for Judge; Robert Bob Perry, III - Treasurer Imprint in Black Disclaimer: Light grey line represents edge of sign and will not print.

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