Echinacea purpurea Studies

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1 Echinacea purpurea Studies

2 ECHINACEA PURPUREA DATABASE 1: Neri PG, Stagni E, Filippello M, Camillieri G, Giovannini A, Leggio GM, Drago F. Related Articles Oral Echinacea purpurea Extract in Low-Grade, Steroid-Dependent, Autoimmune Idiopathic Uveitis: A Pilot Study. J Ocul Pharmacol Ther Dec;22(6): PMID: [PubMed - in process] 2: Wagenius S, Lonsdorf E, Neuhauser C. Patch Aging and the S-Allee Effect: Breeding System Effects on the Demographic Response of Plants to Habitat Fragmentation. Am Nat Jan 17;169(3) [Epub ahead of print] PMID: [PubMed - as supplied by publisher] 3: Hellum BH, Hu Z, Nilsen OG. The Induction of CYP1A2, CYP2D6 and CYP3A4 by Six Trade Herbal Products in Cultured Primary Human Hepatocytes. Basic Clin Pharmacol Toxicol Jan;100(1): PMID: [PubMed - in process] 4: Santaella RM, Fraunfelder FW. Ocular adverse effects associated with systemic medications : recognition and management. Drugs. 2007;67(1): PMID: [PubMed - in process] 5: Senchina DS, Wu L, Flinn GN, Konopka del N, McCoy JA, Widrlechner MP, Wurtele ES, Kohut ML. Year-and-a-Half Old, Dried Echinacea Roots Retain Cytokine- Modulating Capabilities in an in vitro Human Older Adult Model of Influenza Vaccination. Planta Med Dec;72(15):1440. No abstract available. PMID: [PubMed - in process] 6: Liu Y, Murphy PA. Alkamide stability in Echinacea purpurea extracts with and without phenolic acids in dry films and in solution. J Agric Food Chem Jan 10;55(1): PMID: [PubMed - in process] 7: Huntimer ED, Halaweish FT, Chase CC. Proliferative activity of Echinacea angustifolia root extracts on cancer cells: interference with doxorubicin cytotoxicity. Chem Biodivers Jun;3(6): PMID: [PubMed - in process]

3 8: Quimby EL. The use of herbal therapies in pediatric oncology patients: treating symptoms of cancer and side effects of standard therapies. J Pediatr Oncol Nurs Jan-Feb;24(1): PMID: [PubMed - in process] 9: Hill LL, Foote JC, Erickson BD, Cerniglia CE, Denny GS. Echinacea purpurea supplementation stimulates select groups of human gastrointestinal tract microbiota. J Clin Pharm Ther Dec;31(6): PMID: [PubMed - in process] 10: Baillard C, Bianchi A, Gehan G, Sitbon P, Denantes C, Benhamou D, Cupa M, Samama CM. [Anaesthetic preoperative assessment of chronic medications and herbal medicine use: a multicenter survey.] Ann Fr Anesth Reanim Dec 11; [Epub ahead of print] French. PMID: [PubMed - as supplied by publisher] 11: Ball AR, Casadei G, Samosorn S, Bremner JB, Ausubel FM, Moy TI, Lewis K. Conjugating berberine to a multidrug efflux pump inhibitor creates an effective antimicrobial. ACS Chem Biol Oct 24;1(9): PMID: [PubMed - in process] 12: Matovic N, Matthias A, Gertsch J, Raduner S, Bone KM, Lehmann RP, Devoss JJ. Stereoselective synthesis, natural occurrence and CB(2) receptor binding affinities of alkylamides from herbal medicines such as Echinacea sp. Org Biomol Chem Jan 7;5(1): Epub 2006 Nov 29. PMID: [PubMed - in process] 13: Romero FR, Delate K, Hannapel DJ. The effect of seed source, light during germination, and cold-moist stratification on seed germination in three species of Echinacea for organic production. HortScience Oct;40(6): PMID: [PubMed - author manuscript in PMC] 14: Schoop R, Buechi S, Suter A. Open, multicenter study to evaluate the tolerability and efficacy of Echinaforce forte tablets in athletes. Adv Ther Sep-Oct;23(5): PMID: [PubMed - in process]

4 15: Pellati F, Calo S, Benvenuti S. High-performance liquid chromatography analysis of polyacetylenes and polyenes in Echinacea pallida by using a monolithic reversedphase silica column. J Chromatogr A Nov 23; [Epub ahead of print] PMID: [PubMed - as supplied by publisher] 16: Gertsch J, Raduner S, Altmann KH. New natural noncannabinoid ligands for cannabinoid type-2 (CB2) receptors. J Recept Signal Transduct Res. 2006;26(5-6): PMID: [PubMed - in process] 17: Kraus GA, Bae J, Schuster J. The First Synthesis of a Diynone from Echinacea pallida. Synthesis (Stuttg) Dec;2005(20): PMID: [PubMed - author manuscript in PMC] 18: Perri D, Dugoua JJ, Mills E, Koren G. Safety and efficacy of echinacea (Echinacea angustafolia, e. purpurea and e. pallida) during pregnancy and lactation. Can J Clin Pharmacol Fall;13(3):e Epub 2006 Nov 3. Review. PMID: [PubMed - indexed for MEDLINE] 19: Classen B, Thude S, Blaschek W, Wack M, Bodinet C. Immunomodulatory effects of arabinogalactan-proteins from Baptisia and Echinacea. Phytomedicine Nov;13(9-10): Epub 2005 Nov 14. PMID: [PubMed - in process] 20: Qu L, Wang X, Hood E, Scalzo R. Ethephon Promotes Germination of Echinacea angustifolia and E. pallida in Darkness. HortScience Aug;39(5): PMID: [PubMed - author manuscript in PMC] 21: Adinolfi B, Chicca A, Martinotti E, Breschi MC, Nieri P. Sequence characterized amplified region (SCAR) analysis on DNA from the three medicinal Echinacea species. Fitoterapia Jan;78(1):43-5. Epub 2006 Sep 23. PMID: [PubMed - in process] 22: Liu CZ, Abbasi BH, Gao M, Murch SJ, Saxena PK. Caffeic acid derivatives production by hairy root cultures of Echinacea purpurea. J Agric Food Chem Nov 1;54(22): PMID: [PubMed - indexed for MEDLINE]

5 23: Cech NB, Tutor K, Doty BA, Spelman K, Sasagawa M, Raner GM, Wenner CA. Liver Enzyme-Mediated Oxidation of Echinacea purpurea Alkylamides: Production of Novel Metabolites and Changes in Immunomodulatory Activity. Planta Med Dec;72(15): Epub 2006 Oct 20. PMID: [PubMed - in process] 24: Zheng Y, Dixon M, Saxena PK. Growing Environment and Nutrient Availability Affect the Content of Some Phenolic Compounds in Echinacea purpurea and Echinacea angustifolia. Planta Med Dec;72(15): Epub 2006 Oct 20. PMID: [PubMed - in process] 25: Chicca A, Adinolfi B, Martinotti E, Fogli S, Breschi MC, Pellati F, Benvenuti S, Nieri P. Cytotoxic effects of Echinacea root hexanic extracts on human cancer cell lines. J Ethnopharmacol Sep 23; [Epub ahead of print] PMID: [PubMed - as supplied by publisher] 26: Gardiner P, Graham RE, Legedza AT, Eisenberg DM, Phillips RS. Factors associated with dietary supplement use among prescription medication users. Arch Intern Med Oct 9;166(18): PMID: [PubMed - indexed for MEDLINE] 27: Raknes G, Smabrekke L. [Echinacea spp. (coneflower) and upper respiratory tract infections] Tidsskr Nor Laegeforen Oct 5;126(19): Norwegian. No abstract available. PMID: [PubMed - indexed for MEDLINE] 28: Senchina DS, Wu L, Flinn GN, Konopka del N, McCoy JA, Widrelechner MP, Wurtele ES, Kohut ML. Year-and-a-half old, dried Echinacea roots retain cytokine-modulating capabilities in an in vitro human older adult model of influenza vaccination. Planta Med Oct;72(13): Epub 2006 Oct 4. PMID: [PubMed - indexed for MEDLINE]

6 29: Charrois TL, Hrudey J, Vohra S; American Academy of Pediatrics Provisional Section on Complementary, Holistic, and Integrative Medicine. Echinacea. Pediatr Rev Oct;27(10): Review. No abstract available. PMID: [PubMed - indexed for MEDLINE] 30: Wang CY, Chiao MT, Yen PJ, Huang WC, Hou CC, Chien SC, Yeh KC, Yang WC, Shyur LF, Yang NS. Modulatory effects of Echinacea purpurea extracts on human dendritic cells: a cell- and gene-based study. Genomics Dec;88(6): Epub 2006 Sep 29. PMID: [PubMed - indexed for MEDLINE] 31: Sharma M, Arnason JT, Hudson JB. Echinacea extracts modulate the production of multiple transcription factors in uninfected cells and rhinovirus-infected cells. Phytother Res Dec;20(12): PMID: [PubMed - in process] 32: Woelkart K, Marth E, Suter A, Schoop R, Raggam RB, Koidl C, Kleinhappl B, Bauer R. Bioavailability and pharmacokinetics of Echinacea purpurea preparations and their interaction with the immune system. Int J Clin Pharmacol Ther Sep;44(9): PMID: [PubMed - indexed for MEDLINE] 33: Lee LS, Andrade AS, Flexner C. Interactions between natural health products and antiretroviral drugs: pharmacokinetic and pharmacodynamic effects. Clin Infect Dis Oct 15;43(8): Epub 2006 Sep 8. PMID: [PubMed - indexed for MEDLINE] 34: Wang B, Zhang G, Zhu L, Chen L, Zhang Y. Genetic transformation of Echinacea purpurea with Agrobacterium rhizogenes and bioactive ingredient analysis in transformed cultures. Colloids Surf B Biointerfaces Nov 1;53(1): Epub 2006 Aug 17. PMID: [PubMed - in process] 35: Hudson J, Altamirano M. The application of DNA micro-arrays (gene arrays) to the study of herbal medicines. J Ethnopharmacol Nov 3;108(1):2-15. Epub 2006 Aug 18. PMID: [PubMed - in process]

7 36: Kraus GA, Bae J. Synthesis of N-(2-methylpropyl)-2E-undecene-8,10-diynamide, a novel constituent of Echinacea angustifolia. Tetrahedron Lett Jul 14;44(29): PMID: [PubMed - author manuscript in PMC] 37: Gagnier JJ, DeMelo J, Boon H, Rochon P, Bombardier C. Quality of reporting of randomized controlled trials of herbal medicine interventions. Am J Med Sep;119(9):800.e1-11. Review. PMID: [PubMed - indexed for MEDLINE] 38: Messina BA. Herbal supplements: Facts and myths--talking to your patients about herbal supplements. J Perianesth Nurs Aug;21(4):268-78; quiz Review. PMID: [PubMed - indexed for MEDLINE] 39: Yeh GY, Davis RB, Phillips RS. Use of complementary therapies in patients with cardiovascular disease. Am J Cardiol Sep 1;98(5): Epub 2006 Jul 7. PMID: [PubMed - indexed for MEDLINE] 40: Sterer N, Rubinstein Y. Effect of various natural medicinals on salivary protein putrefaction and malodor production. Quintessence Int Sep;37(8): PMID: [PubMed - indexed for MEDLINE] 41: Singh SR, Levine MA. Natural health product use in Canada: analysis of the National Population Health Survey. Can J Clin Pharmacol Summer;13(2):e Epub 2006 Aug 21. PMID: [PubMed - indexed for MEDLINE] 42: Jones MP, Yi Z, Murch SJ, Saxena PK. Thidiazuron-induced regeneration of Echinacea purpurea L.: Micropropagation in solid and liquid culture systems. Plant Cell Rep Jan;26(1):13-9. Epub 2006 Aug 2. PMID: [PubMed - in process] 43: Khaksary Mahabady M, Ranjbar R, Arzi A, Papahn AA, Najafzadeh H. A comparison study of effects of Echinacea extract and levamisole on phenytoin-induced cleft palate in mice. Regul Toxicol Pharmacol Dec;46(3): Epub 2006 Aug 4. PMID: [PubMed - in process]

8 44: Meijerman I, Beijnen JH, Schellens JH. Herb-drug interactions in oncology: focus on mechanisms of induction. Oncologist Jul-Aug;11(7): Review. PMID: [PubMed - indexed for MEDLINE] 45: van den Bout-van den Beukel CJ, Koopmans PP, van der Ven AJ, De Smet PA, Burger DM. Possible drug-metabolism interactions of medicinal herbs with antiretroviral agents. Drug Metab Rev. 2006;38(3): Review. PMID: [PubMed - indexed for MEDLINE] 46: Linde K. Updating systematic reviews. Explore (NY) Jul-Aug;2(4): Review. No abstract available. PMID: [PubMed - indexed for MEDLINE] 47: O'Brien NM, Carpenter R, O'Callaghan YC, O'Grady MN, Kerry JP. Modulatory effects of resveratrol, citroflavan-3-ol, and plant-derived extracts on oxidative stress in U937 cells. J Med Food Summer;9(2): PMID: [PubMed - indexed for MEDLINE] 48: Spelman K, Burns J, Nichols D, Winters N, Ottersberg S, Tenborg M. Modulation of cytokine expression by traditional medicines: a review of herbal immunomodulators. Altern Med Rev Jun;11(2): Review. PMID: [PubMed - indexed for MEDLINE] 49: Brush J, Mendenhall E, Guggenheim A, Chan T, Connelly E, Soumyanath A, Buresh R, Barrett R, Zwickey H. The effect of Echinacea purpurea, Astragalus membranaceus and Glycyrrhiza glabra on CD69 expression and immune cell activation in humans. Phytother Res Aug;20(8): PMID: [PubMed - indexed for MEDLINE] 50: Pellati F, Calo S, Benvenuti S, Adinolfi B, Nieri P, Melegari M. Isolation and structure elucidation of cytotoxic polyacetylenes and polyenes from Echinacea pallida. Phytochemistry Jul;67(13): Epub 2006 Jun 27. PMID: [PubMed - indexed for MEDLINE]

9 51: Trucksess M, Weaver C, Oles C, D'Ovidio K, Rader J. Determination of aflatoxins and ochratoxin A in ginseng and other botanical roots by immunoaffinity column cleanup and liquid chromatography with fluorescence detection. J AOAC Int May-Jun;89(3): PMID: [PubMed - indexed for MEDLINE] 52: Chen P. Development and validation of a high-throughput based on liquid chromatography with ultraviolet absorption and mass spectrometry detection method for quantitation of cichoric acid in Echinacea purpurea aerial-based dietary supplements. J AOAC Int May-Jun;89(3): PMID: [PubMed - indexed for MEDLINE] 53: Cohrssen A. Echinacea's immune effects-possibilities and pitfalls-two cases. Explore (NY) May;2(3): No abstract available. PMID: [PubMed - indexed for MEDLINE] 54: Gillespie EL, Coleman CI. The effect of Echinacea on upper respiratory infection symptom severity and quality of life. Conn Med Feb;70(2):93-7. Review. PMID: [PubMed - indexed for MEDLINE] 55: Ulrich DW, Harrigan R. Echinacea for the common cold: exploring the rational of scientific research on complementary and alternative medical therapies. Hawaii Med J Mar;65(3):88, 93. No abstract available. PMID: [PubMed - indexed for MEDLINE] 56: Thude S, Classen B, Blaschek W, Barz D, Thude H. Binding studies of an arabinogalactan-protein from Echinacea purpurea to leucocytes. Phytomedicine Jun;13(6): Epub 2005 Sep 19. PMID: [PubMed - indexed for MEDLINE] 57: Koenig K, Roehr CC. Does treatment with Echinacea purpurea effectively shorten the course of upper respiratory tract infections in children? Arch Dis Child Jun;91(6): Review. No abstract available. PMID: [PubMed - indexed for MEDLINE] 58: Sasagawa M, Cech NB, Gray DE, Elmer GW, Wenner CA. Echinacea alkylamides inhibit interleukin-2 production by Jurkat T cells. Int Immunopharmacol Jul;6(7): Epub 2006 Mar 7. PMID: [PubMed - indexed for MEDLINE]

10 59: Grudianov AI, Bezrukova IV, Aleksandrovskaia IIu. [Comparative study of homeopathic remedies clinical efficacy in comprehensive treatment of inflammatory periodontal diseases in patients with burdened allergic status] Stomatologiia (Mosk). 2006;85(2):25-8. Russian. PMID: [PubMed - indexed for MEDLINE] 60: Schoop R, Klein P, Suter A, Johnston SL. Echinacea in the prevention of induced rhinovirus colds: a metaanalysis. Clin Ther Feb;28(2): Review. PMID: [PubMed - indexed for MEDLINE] 61: Wagenius S. Scale dependence of reproductive failure in fragmented Echinacea populations. Ecology Apr;87(4): PMID: [PubMed - indexed for MEDLINE] 62: Pan ZG, Liu CZ, Murch SI, Saxena PK. Isolation, culture, and plant regeneration from Echinacea purpurea protoplasts. Methods Mol Biol. 2006;318: PMID: [PubMed - indexed for MEDLINE] 63: Barrett B, Brown R, Voland R, Maberry R, Turner R. Relations among questionnaire and laboratory measures of rhinovirus infection. Eur Respir J Aug;28(2): Epub 2006 Apr 26. PMID: [PubMed - indexed for MEDLINE] 64: Wack M, Blaschek W. Determination of the structure and degree of polymerisation of fructans from Echinacea purpurea roots. Carbohydr Res Jul 3;341(9): Epub 2006 Apr 21. PMID: [PubMed - indexed for MEDLINE] 65: Birosova L, Mikulasova M, Vaverkova S. Antimutagenic effect of phenolic acids. Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub Dec;149(2): PMID: [PubMed - in process] 66: Truchlinski J, Krauze M, Cendrowska-Pinkosz M, Modzelewska-Banachiewicz B. Influence of garlic, synthetic 1,2,4-triasole derivative and herbal preparation echinovit C on selected indices of turkey-hens nonspecific immunity. Pol J Vet Sci. 2006;9(1):51-5. PMID: [PubMed - indexed for MEDLINE]

11 67: Gleeson M. Can nutrition limit exercise-induced immunodepression? Nutr Rev Mar;64(3): Review. PMID: [PubMed - indexed for MEDLINE] 68: Grippo AA, Hamilton B, Hannigan R, Gurley BJ. Metal content of ephedra-containing dietary supplements and select botanicals. Am J Health Syst Pharm Apr 1;63(7): PMID: [PubMed - indexed for MEDLINE] 69: Wilson KM, Klein JD, Sesselberg TS, Yussman SM, Markow DB, Green AE, West JC, Gray NJ. Use of complementary medicine and dietary supplements among U.S. adolescents. J Adolesc Health Apr;38(4): PMID: [PubMed - indexed for MEDLINE] 70: Raduner S, Majewska A, Chen JZ, Xie XQ, Hamon J, Faller B, Altmann KH, Gertsch J. Alkylamides from Echinacea are a new class of cannabinomimetics. Cannabinoid type 2 receptor-dependent and -independent immunomodulatory effects. J Biol Chem May 19;281(20): Epub 2006 Mar 17. PMID: [PubMed - indexed for MEDLINE] 71: Dong GC, Chuang PH, Forrest MD, Lin YC, Chen HM. Immuno-suppressive effect of blocking the CD28 signaling pathway in T-cells by an active component of Echinacea found by a novel pharmaceutical screening method. J Med Chem Mar 23;49(6): PMID: [PubMed - indexed for MEDLINE] 72: Burrowes JD, Van Houten G. Herbs and dietary supplement use in patients with stage 5 chronic kidney disease. Nephrol Nurs J Jan-Feb;33(1):85-8. Review. PMID: [PubMed - indexed for MEDLINE] 73: Li WW, Barz W. Structure and accumulation of phenolics in elicited Echinacea purpurea cell cultures. Planta Med Feb;72(3): PMID: [PubMed - indexed for MEDLINE]

12 74: Clay PG, Glaros AG, Clauson KA. Perceived efficacy, indications, and information sources for medically indigent patients and their healthcare providers regarding dietary supplements. Ann Pharmacother Mar;40(3): Epub 2006 Feb 28. PMID: [PubMed - indexed for MEDLINE] 75: Liatsos G, Elefsiniotis I, Todorova R, Moulakakis A. Severe thrombotic thrombocytopenic purpura (TTP) induced or exacerbated by the immunostimulatory herb Echinacea. Am J Hematol Mar;81(3):224. No abstract available. Erratum in: Am J Hematol Sep;81(9):722. George, Liatsos [corrected to Liatsos, George]; Ioannis, Elefsiniotis [corrected to Elefsiniotis, Ioannis]; Radostina, Todorova [corrected to Todorova, Radostina]; Antonios, Moulakakis [corrected to Moulakakis, Antonios]. PMID: [PubMed - indexed for MEDLINE] 76: Murch SJ, Peiris SE, Shi WL, Zobayed SM, Saxena PK. Genetic diversity in seed populations of Echinacea purpurea controls the capacity for regeneration, route of morphogenesis and phytochemical composition. Plant Cell Rep Jun;25(6): Epub 2006 Feb 14. PMID: [PubMed - indexed for MEDLINE] 77: Kreutzkamp B. [Echinacea angustifolia is ineffective in an experimental study] Med Monatsschr Pharm Jan;29(1): German. No abstract available. PMID: [PubMed - indexed for MEDLINE] 78: Heller J, Gabbay JS, Ghadjar K, Jourabchi M, O'Hara C, Heller M, Bradley JP. Top-10 list of herbal and supplemental medicines used by cosmetic patients: what the plastic surgeon needs to know. Plast Reconstr Surg Feb;117(2):436-45; discussion PMID: [PubMed - indexed for MEDLINE] 79: Sharma M, Arnason JT, Burt A, Hudson JB. Echinacea extracts modulate the pattern of chemokine and cytokine secretion in rhinovirus-infected and uninfected epithelial cells. Phytother Res Feb;20(2): PMID: [PubMed - indexed for MEDLINE] 80: Lohse B, Stotts JL, Priebe JR. Survey of herbal use by Kansas and Wisconsin WIC participants reveals moderate, appropriate use and identifies herbal education needs. J Am Diet Assoc Feb;106(2): PMID: [PubMed - indexed for MEDLINE]

13 81: Linde K, Barrett B, Wolkart K, Bauer R, Melchart D. Echinacea for preventing and treating the common cold. Cochrane Database Syst Rev Jan 25;(1):CD Review. PMID: [PubMed - indexed for MEDLINE] 82: Qu L, Chen Y, Wang X, Scalzo R, Davis JM. Patterns of Variation in Alkamides and Cichoric Acid in Roots and Aboveground Parts of Echinacea purpurea (L.) Moench. HortScience Aug;40(5): PMID: [PubMed - author manuscript in PMC] 83: Qu L, Wang X, Hood E, Wang M, Scalzo R. Chromosome Karyotypes of Echinacea angustifolia var. angustifolia and E. purpurea. HortScience Apr;39(2): PMID: [PubMed - author manuscript in PMC] 84: Qu L, Wang X, Chen Y, Scalzo R, Widrlechner MP, Davis JM, Hancock JF. Commercial Seed Lots Exhibit Reduced Seed Dormancy in Comparison to Wild Seed Lots of Echinacea purpurea. HortScience Oct;40(6): PMID: [PubMed - author manuscript in PMC] 85: Fuchikami H, Satoh H, Tsujimoto M, Ohdo S, Ohtani H, Sawada Y. Effects of herbal extracts on the function of human organic aniontransporting polypeptide OATP-B. Drug Metab Dispos Apr;34(4): Epub 2006 Jan 13. PMID: [PubMed - indexed for MEDLINE] 86: Mattsson KR, Altsjo C. [Common cold guidelines in pharmacies not ungrounded] Lakartidningen Dec 5-11;102(49):3823. Swedish. No abstract available. PMID: [PubMed - indexed for MEDLINE] 87: Bruhn JG. [Lakartidningen and natural remedies--where is the nuanced information?] Lakartidningen Dec 5-11;102(49):3816-7; discussion 3817, Swedish. No abstract available. PMID: [PubMed - indexed for MEDLINE] 88: [No authors listed] Study shows echinacea doesn't prevent or ease cold symptoms. Mayo Clin Womens Healthsource Jan;10(1):3. No abstract available. PMID: [PubMed - indexed for MEDLINE]

14 89: McIntyre M. Commentary: time to research echinacea properly. J Altern Complement Med Dec;11(6): No abstract available. PMID: [PubMed - indexed for MEDLINE] 90: Weber W, Taylor JA, Stoep AV, Weiss NS, Standish LJ, Calabrese C. Echinacea purpurea for prevention of upper respiratory tract infections in children. J Altern Complement Med Dec;11(6): PMID: [PubMed - indexed for MEDLINE] 91: Bernatoniene J, Savickas A, Masteikova R, Chalupova Z. [Composite tincture from the tops of the purple coneflower (Echinacea purpurea) and the fruits of the dog rose (Rosa canina): technology of production and evaluation of quality] Ceska Slov Farm Nov;54(6): Czech. PMID: [PubMed - indexed for MEDLINE] 92: Carr RR, Nahata MC. Complementary and alternative medicine for upper-respiratory-tract infection in children. Am J Health Syst Pharm Jan 1;63(1):33-9. Review. PMID: [PubMed - indexed for MEDLINE] 93: Wang X, Geng Y, Li F, Gao Q, Shi X. Preparative separation of cichoric acid from Echinacea purpurea by ph-zone-refining counter-current chromatography. J Chromatogr A Jan 20;1103(1): Epub 2005 Dec 20. PMID: [PubMed - indexed for MEDLINE] 94: Wist TJ, Davis AR. Floral nectar production and nectary anatomy and ultrastructure of Echinacea purpurea (Asteraceae). Ann Bot (Lond) Feb;97(2): Epub 2005 Dec 9. PMID: [PubMed - indexed for MEDLINE] 95: Malekzadeh F, Rose C, Ingvar C, Jernstrom H. [Natural remedies and hormone preparations--potential risk for breast cancer patients. A study surveys the use of agents which possibly counteract with the treatment] Lakartidningen Oct 31-Nov 6;102(44):3226-8, Swedish. PMID: [PubMed - indexed for MEDLINE] 96: Zaffani S, Cuzzolin L, Benoni G. Herbal products: behaviors and beliefs among Italian women. Pharmacoepidemiol Drug Saf May;15(5): PMID: [PubMed - indexed for MEDLINE]

15 97: Naser B, Lund B, Henneicke-von Zepelin HH, Kohler G, Lehmacher W, Scaglione F. A randomized, double-blind, placebo-controlled, clinical doseresponse trial of an extract of Baptisia, Echinacea and Thuja for the treatment of patients with common cold. Phytomedicine Nov;12(10): PMID: [PubMed - indexed for MEDLINE] 98: Dalby-Brown L, Barsett H, Landbo AK, Meyer AS, Molgaard P. Synergistic antioxidative effects of alkamides, caffeic acid derivatives, and polysaccharide fractions from Echinacea purpurea on in vitro oxidation of human low-density lipoproteins. J Agric Food Chem Nov 30;53(24): PMID: [PubMed - indexed for MEDLINE] 99: Cech NB, Eleazer MS, Shoffner LT, Crosswhite MR, Davis AC, Mortenson AM. High performance liquid chromatography/electrospray ionization mass spectrometry for simultaneous analysis of alkamides and caffeic acid derivatives from Echinacea purpurea extracts. J Chromatogr A Jan 27;1103(2): Epub 2005 Nov 18. PMID: [PubMed - indexed for MEDLINE] 100: Arroll B. Non-antibiotic treatments for upper-respiratory tract infections (common cold). Respir Med Dec;99(12): PMID: [PubMed - indexed for MEDLINE] 101: Delorme D, Miller SC. Dietary consumption of Echinacea by mice afflicted with autoimmune (type I) diabetes: effect of consuming the herb on hemopoietic and immune cell dynamics. Autoimmunity Sep;38(6): PMID: [PubMed - in process] 102: Krahmer N, Hahn EG. [Complementary and alternative medical approaches to infection prophylaxis in the elderly] MMW Fortschr Med Oct 13;147(41):30-3. German. PMID: [PubMed - indexed for MEDLINE] 103: Leach M. Echinacea angustifolia in rhinovirus infections. N Engl J Med Nov 3;353(18):1971-2; author reply No abstract available. PMID: [PubMed - indexed for MEDLINE]

16 104: Blumenthal M, Farnsworth NR. Echinacea angustifolia in rhinovirus infections. N Engl J Med Nov 3;353(18):1971-2; author reply No abstract available. PMID: [PubMed - indexed for MEDLINE] 105: Basch E, Ulbricht C, Basch S, Dalton S, Ernst E, Foppa I, Szapary P, Tiffany N, Orlando CW, Vora M. An evidence-based systemic review Echinacea E. angustifolia DC, E. pallida, E. purpurea by the Natural Standard Research Collaboration. J Herb Pharmacother. 2005;5(2): Review. No abstract available. PMID: [PubMed - indexed for MEDLINE] 106: Rousseau B, Tateya I, Lim X, Munoz-del-Rio A, Bless DM. Investigation of anti-hyaluronidase treatment on vocal fold wound healing. J Voice Sep;20(3): Epub 2005 Oct 21. PMID: [PubMed - in process] 107: [No authors listed] Echinacea and the common cold. Child Health Alert Sep;24:4. No abstract available. PMID: [PubMed - indexed for MEDLINE] 108: Rusu MA, Tamas M, Puica C, Roman I, Sabadas M. The hepatoprotective action of ten herbal extracts in CCl4 intoxicated liver. Phytother Res Sep;19(9): PMID: [PubMed - indexed for MEDLINE] 109: Brovelli EA, Rua D, Roh-Schmidt H, Chandra A, Lamont E, Noratto GD. Human gene expression as a tool to determine horticultural maturity in a bioactive plant (Echinacea purpurea L. Moench). J Agric Food Chem Oct 19;53(21): PMID: [PubMed - indexed for MEDLINE] 110: Chow G, Johns T, Miller SC. Dietary Echinacea purpurea during murine pregnancy: effect on maternal hemopoiesis and fetal growth. Biol Neonate. 2006;89(2): Epub 2005 Oct 5. PMID: [PubMed - indexed for MEDLINE]

17 111: Perfect MM, Bourne N, Ebel C, Rosenthal SL. Use of complementary and alternative medicine for the treatment of genital herpes. Herpes Oct;12(2): Review. PMID: [PubMed - indexed for MEDLINE] 112: Wolsko PM, Solondz DK, Phillips RS, Schachter SC, Eisenberg DM. Lack of herbal supplement characterization in published randomized controlled trials. Am J Med Oct;118(10): Review. PMID: [PubMed - indexed for MEDLINE] 113: Di Carlo G, Pacilio M, Capasso R, Di Carlo R. Effect on prolactin secretion of Echinacea purpurea, hypericum perforatum and Eleutherococcus senticosus. Phytomedicine Sep;12(9): PMID: [PubMed - indexed for MEDLINE] 114: Schwarz E, Parlesak A, Henneicke-von Zepelin HH, Bode JC, Bode C. Effect of oral administration of freshly pressed juice of Echinacea purpurea on the number of various subpopulations of B- and Tlymphocytes in healthy volunteers: results of a double-blind, placebo-controlled cross-over study. Phytomedicine Sep;12(9): PMID: [PubMed - indexed for MEDLINE] 115: Goel V, Lovlin R, Chang C, Slama JV, Barton R, Gahler R, Bauer R, Goonewardene L, Basu TK. A proprietary extract from the echinacea plant (Echinacea purpurea) enhances systemic immune response during a common cold. Phytother Res Aug;19(8): PMID: [PubMed - indexed for MEDLINE] 116: Baranauskas A, Bernatoniene J, Radziunas R, Bernatonis D. [Technology of extract improving the immune system] Medicina (Kaunas). 2005;41(8): Lithuanian. PMID: [PubMed - indexed for MEDLINE] 117: Woelkart K, Xu W, Pei Y, Makriyannis A, Picone RP, Bauer R. The endocannabinoid system as a target for alkamides from Echinacea angustifolia roots. Planta Med Aug;71(8): PMID: [PubMed - indexed for MEDLINE]

18 118: Miller SC. Echinacea: a miracle herb against aging and cancer? Evidence in vivo in mice. Evid Based Complement Alternat Med Sep;2(3): PMID: [PubMed] 119: Arroll B. Common cold. Clin Evid Jun;(13): Review. No abstract available. Update in: Clin Evid Jun;(15): PMID: [PubMed - indexed for MEDLINE] 120: Narimanian M, Badalyan M, Panosyan V, Gabrielyan E, Panossian A, Wikman G, Wagner H. Randomized trial of a fixed combination (KanJang) of herbal extracts containing Adhatoda vasica, Echinacea purpurea and Eleutherococcus senticosus in patients with upper respiratory tract infections. Phytomedicine Aug;12(8): PMID: [PubMed - indexed for MEDLINE] 121: Healy B. Echinacea's war. US News World Rep Aug 8;139(5):56. No abstract available. PMID: [PubMed - indexed for MEDLINE] 122: Barnes J, Anderson LA, Gibbons S, Phillipson JD. Echinacea species (Echinacea angustifolia (DC.) Hell., Echinacea pallida (Nutt.) Nutt.,Echinacea purpurea (L.) Moench): a review of their chemistry, pharmacology and clinical properties. J Pharm Pharmacol Aug;57(8): Review. PMID: [PubMed - indexed for MEDLINE] 123: Guenther E, Mendoza J, Crouch BI, Moyer-Mileur LJ, Junkins EP Jr. Differences in herbal and dietary supplement use in the Hispanic and non-hispanic pediatric populations. Pediatr Emerg Care Aug;21(8): PMID: [PubMed - indexed for MEDLINE] 124: Hemila H. Echinacea, vitamin C, the common cold, and blinding. Clin Infect Dis Sep 1;41(5):762-3; author reply No abstract available. PMID: [PubMed - indexed for MEDLINE] 125: Barton R. Efficacy of echinilin for the common cold. Clin Infect Dis Sep 1;41(5):761-2; author reply No abstract available. PMID: [PubMed - indexed for MEDLINE]

19 126: Turner RB, Bauer R, Woelkart K, Hulsey TC, Gangemi JD. An evaluation of Echinacea angustifolia in experimental rhinovirus infections. N Engl J Med Jul 28;353(4): PMID: [PubMed - indexed for MEDLINE] 127: Sampson W. Studying herbal remedies. N Engl J Med Jul 28;353(4): No abstract available. PMID: [PubMed - indexed for MEDLINE] 128: Brousseau M, Miller SC. Enhancement of natural killer cells and increased survival of aging mice fed daily Echinacea root extract from youth. Biogerontology. 2005;6(3): PMID: [PubMed - indexed for MEDLINE] 129: [No authors listed] Which alternative treatments work? Consum Rep Aug;70(8): No abstract available. PMID: [PubMed - indexed for MEDLINE] 130: Still DW, Kim DH, Aoyama N. Genetic variation in Echinacea angustifolia along a climatic gradient. Ann Bot (Lond) Sep;96(3): Epub 2005 Jul 1. PMID: [PubMed - indexed for MEDLINE] 131: Yale SH, Glurich I. Analysis of the inhibitory potential of Ginkgo biloba, Echinacea purpurea, and Serenoa repens on the metabolic activity of cytochrome P450 3A4, 2D6, and 2C9. J Altern Complement Med Jun;11(3): PMID: [PubMed - indexed for MEDLINE] 132: Agnew LL, Guffogg SP, Matthias A, Lehmann RP, Bone KM, Watson K. Echinacea intake induces an immune response through altered expression of leucocyte hsp70, increased white cell counts and improved erythrocyte antioxidant defences. J Clin Pharm Ther Aug;30(4): PMID: [PubMed - indexed for MEDLINE] 133: Liqing Z, Bochu W, Jing Z, Lingxi C, Chuanyun D, Chuanren D. Protoplast isolation of callus in Echinacea augustifolia. Colloids Surf B Biointerfaces Jul 25;44(1):1-5. PMID: [PubMed - indexed for MEDLINE]

20 134: Maass N, Bauer J, Paulicks BR, Bohmer BM, Roth-Maier DA. Efficiency of Echinacea purpurea on performance and immune status in pigs. J Anim Physiol Anim Nutr (Berl) Aug;89(7-8): PMID: [PubMed - indexed for MEDLINE] 135: Grauer RP, Thomas RD, Tronson MD, Heard GC, Diacon M. Preoperative use of herbal medicines and vitamin supplements. Anaesth Intensive Care Apr;32(2): PMID: [PubMed - indexed for MEDLINE] 136: Morazzoni P, Cristoni A, Di Pierro F, Avanzini C, Ravarino D, Stornello S, Zucca M, Musso T. In vitro and in vivo immune stimulating effects of a new standardized Echinacea angustifolia root extract (Polinacea). Fitoterapia Jul;76(5): PMID: [PubMed - indexed for MEDLINE] 137: Hsu S. Green tea and the skin. J Am Acad Dermatol Jun;52(6): Review. PMID: [PubMed - indexed for MEDLINE] 138: Chen Y, Fu T, Tao T, Yang J, Chang Y, Wang M, Kim L, Qu L, Cassady J, Scalzo R, Wang X. Macrophage activating effects of new alkamides from the roots of Echinacea species. J Nat Prod May;68(5): PMID: [PubMed - indexed for MEDLINE] 139: Matthias A, Addison RS, Penman KG, Dickinson RG, Bone KM, Lehmann RP. Echinacea alkamide disposition and pharmacokinetics in humans after tablet ingestion. Life Sci Sep 2;77(16): PMID: [PubMed - indexed for MEDLINE] 140: Everett LL, Birmingham PK, Williams GD, Brenn BR, Shapiro JH. Herbal and homeopathic medication use in pediatric surgical patients. Paediatr Anaesth Jun;15(6): PMID: [PubMed - indexed for MEDLINE]

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