Session I From biochemistry to biotechnology, part I BEL-AMI Hotel Conference Room Chair: Joanna Bereta

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1 PROGRAMME TUESDAY, 16 FEBRUARY :30 Departure from Kraków Faculty of Biochemistry, Biophysics and Biotechnology, 7 Gronostajowa St., Krakow 12:00-13:00 Registration 14:05-14:15 Opening of the XLIII Winter School Session I From biochemistry to biotechnology, part I Chair: Joanna Bereta 14:15-14:45 Andrzej Kozik (Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University): 45 years in research; the scientific road of professor Adam Dubin 14:45-15:30 Gay Salvesen (Sanford-Burnham Medical Research Institute, La Jolla, USA): Inflammatory cell death 15:30-16:00 Joanna Cichy (Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University): The role of Secretory Leukocyte Protease Inhibitor (SLPI) in skin disease-psoriasis 16:00-16:30 Coffee break/meet the Speakers Session II From biochemistry to biotechnology, part II Chair: Joanna Cichy 16:30-17:00 Stanisław Bielecki (Faculty of Biotechnology and Food Sciences, Technical University of Lodz): Bacterial nanocellulose: from cell to industry

2 17:00-17:30 Claudine Kieda (Centre de biophysique moléculaire, CNRS, Orleans, France; Malopolska Centre of Biotechnology, Jagiellonian University): Fighting the hypoxic stress in cancer to restore anti tumor immune response 17:30-18:00 Marcin Drąg (Faculty of Chemistry, Wroclaw University of Technology): Hybrid Combinatorial Substrate Library in design of specific and active probes for proteolytic enzymes 18:00-18:30 Mathias Bochtler (International Institute of Molecular and Cell Biology, Warsaw; Institute of Biochemistry and Biophysics, Polish Academy of Sciences): Methylation/Hydroxymethylation control of endonuclease activity 20:30 Welcome Banquet BY INVITATION ONLY Hotel Kasprowy (Invited participants meet at 20:00 in the ) WEDNESDAY, 17 FEBRUARY :00-10:00 Breakfast 10:00-13:00 Free time/trip to Kościeliska Valley Session I Enzymes in action; host-pathogen interactions Chair: Grzegorz Dubin 14:00-14:30 Marcin Kamiński (German Cancer Research Center DKFZ, Heidelberg, Germany): An ancient twist in T cell activation - ADP-dependent glucokinase, a typically archaeal enzyme, participates in T cell receptor-induced metabolic switch 14:30-15:00 Joanna Skórko-Glonek (Faculty of Biology, University of Gdańsk): The role of the regulatory loops in stimulation and maintaining of the proteolytic activity of the HtrA (DegP) protease from Escherichia coli 15:00-15:30 Adam Lesner (Faculty of Chemistry, University of Gdańsk): Variety of protease detection methods the overview 15:30-15:40 Coffee break/meet the Speakers

3 15:40-16:10 Michał Biśta (AstraZeneca PLC, Cambridge, UK): Potent and selective inhibitors of MTH1 probe its role in cancer cell survival 16:10-16:30 Justyna Karkowska-Kuleta (Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University): Characterization of the interactions between human high-molecular-mass kininogen and cell wall proteins of pathogenic yeast Candida tropicalis 16:30-16:45 Coffee break/meet the Speakers Session II Genome editing; regulation of gene expression Chair: Benedykt Władyka 16:45-17:15 Grzegorz Węgrzyn (Faculty of Biology, University of Gdańsk): Newly discovered regulations of gene expression in lambdoid bacteriophages 17:15-17:45 Józef Dulak (Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University): Gene editing: should we be afraid of it? 17:45-18:00 Szymon Czauderna (Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University): Evaluation of CRISPR/Cas9 efficiency for muscle-specific Mir-378a targeting in vivo 18:00-18:15 Katarzyna Pietraszek-Gremplewicz (Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University): Role of heme oxygenase-1 in Duchenne muscular dystrophy: effect on micrornas 18:15-20:00 Poster session I/Flash talks by poster presenters 20:00-21:00 Dinner 21:00 Beer Party OPEN EVENT NO INVITATIONS /Main Lobby This open event will give you a chance to taste beer proudly brewed at the Faculty of Biochemistry, Biophysics and Biotechnology. It s not a joke, this is a biotech product of a teaching module called Production of beer as an example of biotechnological process, a practical course (WBT-BT610). Everyone is invited to try our limited, winter school editions of Saison and Dunkelweizen!

4 8:00-10:00 Breakfast THURSDAY, 18 FEBRUARY :00-13:00 Free time/ski competition Harenda Ski Resort Session I Structure-function relationships Chair: Marcin Drąg 14:00-14:30 Jerzy Dobrucki (Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University): Super-resolution imaging of nuclear structure 14:30-15:00 Michał Bukowski (Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University): NGS-driven comparative genomics of virulent and non-virulent Staphylococcus aureus 15:00-15:30 Grzegorz Popowicz (Institute of Structural Biology, Helmholtz Zentrum München, Germany): Trypanosoma Achilles heel: Protein-protein interaction inhibitors against parasites 15:30-16:00 Wojciech Dzwolak (The Biological and Chemical Research Centre, University of Warsaw): Misfolding and aggregation of insulin: from the banal to the bizarre 16:00-16:30 Coffee break/meet the Speakers Session II Protein-protein interactions; protein in use Chair: Grzegorz Węgrzyn 16:30-17:00 Jonathan Heddle (Malopolska Centre of Biotechnology, Jagiellonian University): Bionanocience and nanobots: At the thin edge of synthetic biology 17:00-17:20 Bożena Szelążek (Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University): From structure to function an insight into initial steps of nucleocapsid formation of Human Coronavirus NL63 17:20-17:40 Krzysztof Żak (Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University; Malopolska Centre of Biotechnology, Jagiellonian University): Structure of the complex of human Programmed Death 1 (PD-1) and

5 its ligand (PD-L1) 17:40-18:00 Aleksandra Twarda (Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University; Malopolska Centre of Biotechnology, Jagiellonian University): Structural aspects of the inhibition of the p53-mdm2/mdmx interaction 18:00-18:20 Piotr Stępień (Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University): The long road to complete in vitro D2 dopamine receptor and G proteins model 18:20-18:30 Edyta Korbut (LE STUDIUM Loire Valley Institute for Advanced Studies): Biopharmaceuticals in the region Centre-Val de Loire, France 18:30-20:00 Poster session II/Flash talks by poster presenters 20:00-21:00 Dinner 21:00 Wine Party OPEN EVENT NO INVITATIONS /Main Lobby FRIDAY, 19 FEBRUARY :00-10:00 Breakfast 10:00-13:00 Free time/trip to Chochołowska Valley Session I Biology of animal and plant cells; cell biophysics Chair: Claudine Kieda 15:00-15:30 Marta Miączyńska (International Institute of Molecular and Cell Biology, Warsaw): ESCRT-ing cytokine receptors: stress signaling from the endocytic pathway 15:30-16:00 Robert Ekiert (Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University): The effects of mitochondrial disease-related mutation in cytochrome b, G290D, on the motion of iron-sulfur protein and superoxide production studied in Rhodobacter capsulatus

6 16:00-16:15 Coffee break/meet the Speakers 16:15-16:30 Katarzyna Kmiotek (Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University): Optimized isolation of mesenchymal stem cell-derived extracellular vesicles for future applications in heart regeneration in humans 16:30-16:45 Anna Łabędź-Masłowska (Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University): Extracellular Vesicles derived from Mesenchymal Stem Cells as a new promising tool in regeneration of ischemic tissue injury 16:45-17:00 Marta Adamiak (Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University): Molecular composition and potential functional applications of extracellular vesicles derived from induced pluripotent stem cells in heart repair 17:00-17:15 Elżbieta Karnas (Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University): The functional impact of hips-derived extracellular vesicles on human cord blood-derived CD34+ and Lin- fractions 17:15-17:25 Closing of the XLIII Winter School Award ceremonies 20:30 Farewell party BY INVITATION ONLY Restaurant Góralska Tradycja (Invited participants meet at 20:00 in the ) 8:00-10:00 Breakfast 10:30 Departure to Kraków SATURDAY, 20 FEBRUARY 2016

7 ADDITIONAL INORMATION To learn more about parties, trips and how to use your free time in this beautiful town see the INFORMATION FLIER added to your conference materials. POSTER SESSION I Posters (1-40) will be displayed on Wednesday, 17 February 2016 at the BEL-AMI Hotel Conference Room from 12:00 to 20:00. Authors available from 18:15 to 20:00. POSTER SESSION II Posters (41-80) will be displayed on Thursday, 18 February 2016 at the BEL-AMI Hotel Conference Room from 12:00 to 20:00. Authors available from 19:00 to 20:00.