CORPORATE PRESENTATION

Transcription

1 CORPORATE PRESENTATION 1537 NW 65th Avenue Plantation, FL USA Phone: (954) Fax: (954)

2 OVERVIEW ReceptoPharm is an innovative biopharmaceutical drug discovery company developing proprietary therapeutic protein products and providing specialized contract services catering to small and start-up biotechnology companies.

3 Introduction ReceptoPharm is a biopharmaceutical drug discovery company based in Plantation, Florida. The Company is primarily engaged in the discovery and development of novel and off-patent peptide technologies for the prevention and treatment of disease in humans. In 2008, ReceptoPharm began offering a full range of contract services catering to small and start-up biotechnology companies. OVERVIEW Drug Development The emphasis of ReceptoPharm's approach to drug discovery and the development of new therapeutic agents is based upon specialized receptor-binding proteins found in nature. With its' large volume of research and preclinical data ReceptoPharm believes it has identified a number of therapeutic products that have the capability to provide significant benefits for patients with neurological, immunological, autoimmune and viral conditions. CRO Services ReceptoPharm offers a full range of contract services catering to start-up and small biotechnology companies. These services include pre-production studies, contract manufacturing services, US & EU regulatory support, and quality systems/gmp certification.

4 Management Team ReceptoPharm s management is comprised of a team of highly experienced businesspeople and scientists with over 100 years of combined industry expertise. OVERVIEW Name Rik J. Deitsch Paul F. Reid, Ph.D. Laurence N. Raymond, Ph.D. Harold Rumph Chairman and Chief Executive Officer, Nutra Pharma Corporation Chief Executive Officer, ReceptoPharm Chief Scientific Officer, ReceptoPharm Director, ReceptoPharm

5 Advisors ReceptoPharm maintains collaborative and research relationships with a number of noted academic researchers associated with the National Institutes of Health (NIH), Harvard University, Massachusetts General Hospital, Yale University, Baylor College of Medicine and Soochow University. OVERVIEW Name Dorothy Bray, Ph.D. Zouhair M. Atassi, Ph.D., D.Sc. Zheng-Hong Qin, MD, Ph.D. Thomas L. Lentz, MD Organization ImmunoClin Ltd. Baylor College of Medicine Harvard University / Massachusetts General Hospital (Boston, Massachusetts) and Soochow University (Suzhou, China) Yale University

6 DRUG DISCOVERY ReceptoPharm conducts research into a number of products with applications for neurological, immunological, autoimmune and viral conditions. The Company s leading drug candidates are RPI-MN and RPI-78M.

7 Drug Discovery Overview ReceptoPharm is an innovative biopharmaceutical drug discovery company developing proprietary therapeutic protein products for the billion-dollar biologics market. The Company has two leading products: RPI-MN and RPI-78M. RPI-MN RPI-MN inhibits the entry of several viruses that are known to cause severe neurological damage in such diseases as encephalitis and Human Immunodeficiency Virus (HIV). It is being developed first for the treatment of HIV. DRUG DISCOVERY RPI-78M RPI-78M is being developed for the treatment of Multiple Sclerosis (MS) and Adrenomyeloneuropathy (AMN). Other neurological disorders that may be served by RPI-78M include Myasthenia Gravis (MG) and Amyotrophic Lateral Sclerosis (ALS). RPI-78M and RPI-MN contain anticholinergic peptides that recognize the same receptors as nicotine (acetylcholine receptors) but have the opposite effect. In a specific chemical process unique to ReceptoPharm, the drugs are created through a process of chemical modification.

8 Benefits of RPI-MN and RPI-78M RPI-MN and RPI-78M possess several desirable properties as drugs: 1. They lack measurable toxicity but are still capable of attaching to and affecting the target site on the nerve cells. This means that patients cannot overdose. 2. They display no serious adverse side effects following years of investigations in humans and animals. DRUG DISCOVERY 3. They are extremely stable and resistant to heat, which gives the drugs a long shelf life. The drugs' stability has been determined to be over 4 years at room temperature. This is extremely unusual for a biologic drug. 4. They are easy to administer. 5. RPI-78M can be administered orally -- a first for a biologic MS drug. This will present MS patients with additional quality of life benefits by eliminating the requirement for routine injections.

9 Specific Benefits of RPI-MN Benefits of ReceptoPharm s HIV/AIDs Treatment RPI-MN Fuzeon by Roche/Trimeris Mutations are not Created Mutations are Created Relatively Inexpensive Very Expensive Twice Current Therapies DRUG DISCOVERY No Significant Adverse Side Effects Long Shelf Life Patient Does Not Develop Resistance Easy to Manufacture Adverse Side Effects Present Some Severe Limited Shelf Life Patient Develops Immune Resistance Difficult Manufacturing Leads to Limited Use

10 Specific Benefits of RPI-78M Benefits of ReceptoPharm s Multiple Sclerosis (MS) Treatment RPI-78M Competitive Drugs Disease Progress Stops Disease Progression Only Slows Patient Condition Improves No Claims Against Patient Improvement DRUG DISCOVERY No Significant Adverse Side Effects Long Shelf Life Resistant to Heat Patient Does Not Develop Resistance Improves Quality of Life Adverse Side Effects Present Some Severe Limited Shelf Life Requires Refrigeration Patient Develops Immune Resistance No Evidence for Quality of Life Improvement

11 Cobroxin Overview Cobroxin is the first over-the-counter pain reliever clinically proven to treat Stage 2 (moderate to severe) chronic pain. Cobroxin, which was developed by ReceptoPharm, was launched in August 2009 and will be available as an oral spray for treating lower back pain, migraines, neck aches, shoulder pain, cramps and neuralgia and as a topical gel for treating joint pain and pain associated with repetitive stress and arthritis. DRUG DISCOVERY Additional Benefits to Cobroxin Include: All Natural Non-Addictive Non-Narcotic Non-Opiate More Potent than Morphine Long Lasting

12 Cobroxin Market Potential Pain is the single most common reason patients seek medical care and accounts for half of all physician office visits in the United States. According to the American Pain Foundation, each year, more than 25 million people in the United States experience acute pain as a result of injury or surgery. Additionally, more than 50 million people in the United States are affected by ongoing chronic pain. DRUG DISCOVERY The Cobroxin Advantage: 1. Makes potent pain relief accessible to: People without healthcare insurance (42 million) People without prescription coverage People afraid of opiate side effects People subject to drug screening for work People for whom OTC NSAIDs didn t work and are just living with the pain Doctors afraid to prescribe opiates 2. Targets consumers not well-served by current products

13 Research & Development Pipeline ReceptoPharm's research and development pipeline consists of several novel therapies in various stages of development to prevent and/or treat Multiple Sclerosis (MS), Human Immunodeficiency Virus (HIV), Adrenomyeloneuropathy (AMN), Herpes, Rheumatoid Arthritis (RA) and Pain. DRUG DISCOVERY Abbreviations: Preclinical (PC), Phase 1 (P-I), Phase 2 (P-II), Phase 3 (P-III)

14 Published Research Cobratoxin Inhibits Pain-Evoked Discharge of Neurons in Thalamic Parafascicular Nucleus in Rats: Involvement of cholinergic and serotonergic systems // Toxicon (April 2009) Alpha Cobratoxin as a Possible Therapy for Multiple Sclerosis: A Review of the Literature leading to Its Development for This Application // Critical Reviews in Immunology (Volume 27 / Issue ) DRUG DISCOVERY Analgesic Effects of Receptin, a Chemically Modified Cobratoxin from Thailand Cobra Venom // Neuroscience Bulletin (September 2006) Amelioration of Acute and Relapsing Stages of the Experimental Allergic Encephalomyelitis by Cobra Toxins // Biomedical Sciences Instrumentation (June 2006) A Long-Form a-neurotoxin from Cobra Venom Produces Potent Opioid-Independent Analgesia // Acta Pharmacologica Sinica (April 2006) A Short-Chain a-neurotoxin from Naja naja atra Produces Potent Cholinergic-Dependent Analgesia // Neuroscience Bulletin (March 2006)

15 CONTRACT RESEARCH SERVICES ReceptoPharm has installed the pathways to develop, produce and supply clinical material for Phase I and II studies at the highest levels. In 2008, the Company began offering services catering to small and start-up biotechnology companies.

16 Partnering with ReceptoPharm As a clinical stage company specializing in biologics, ReceptoPharm has cleared many of the hurdles that face emerging biotech companies. Below are the top reasons that companies choose to partner with ReceptoPharm as its CRO: 1. Therapeutic experience encompassing infectious disease, autoimmune conditions, neurological disorders and oncology indications. 2. A renowned team of scientists, led by Dr. Paul Reid, specializing in human and veterinary regulatory affairs for the United States, Canada, and Europe, and drug applications (pre IND, IND and Orphan), drug production, new drug development, clinical trial design, patient monitoring, and experimental design. CONTRACT RESEARCH SERVICES 3. Significant investment in establishing a production facility to meet US and EU standards, including the installation of quality systems to meet GMP standards and ISO Class 5 certification.

17 A Global View on Drug Development ReceptoPharm prides itself on taking a global view on drug development; whether it s preparing submissions, protocols, formulations, or organizing clinical trials internationally. ReceptoPharm has invested heavily in establishing its own production facility to meet US and EU standards, including the installation of quality systems to meet GMP standards. Its commitment to maintaining the highest quality standards can now be used as a resource by other biopharmaceutical companies. CONTRACT RESEARCH SERVICES

18 Top-Rated Drug Production Facilities Establishing and maintaining a qualified drug production facility can represent a significant drain on a small company s resources. ReceptoPharm understands that its investment in manufacturing and its first-hand knowledge in drug discovery and development can be very valuable assets to small companies that do not have these resources or capabilities inhouse. Working with ReceptoPharm through its ISO class 5 and GMP certified facilities will allow these companies to avoid considerable clinical development expenses and allow them to focus on a more important task, expeditiously getting their products to the next stage. CONTRACT RESEARCH SERVICES

19 Pre-Production Studies Stability Studies Formulation Adventitious Viral Testing Preservative Efficacy Testing Assay Development/Potency Testing Methods Development US & EU Regulatory Support FDA Drug Applications, IND Preparation EU Submissions, IMPD Preparation Sterile Filling Capabilities ReceptoPharm can manually fill a variety of drug products for your clinical development projects in the US and EU. While ReceptoPharm specializes in biologics, including MAbs, natural, recombinant and synthetic proteins, it can also prepare and fill pharmaceutical products in its ISO class 5 cleanroom facilities. Contract Manufacturing Services Drug Formulation ISO 5 Sterile Filling Suite, Single and Multi-Dose Liquids for Injection Clinical Trial Supplies to FDA & EU Requirements Packaging and Shipment to Sites Release Testing and Certification Quality Systems/GMP Certification Installation of Quality Systems Using Our SOPs GMP Audits GMP Training QA Function IQ/OQ/PQ Validations (Equipment and Processes) CONTRACT RESEARCH SERVICES

20 CONTACT RECEPTOPHARM 1537 NW 65th Avenue Plantation, FL USA Phone: (954) Fax: (954)