Mapping of Advanced Materials Deployment for Societal Changes: Nanomedicine in Latin America Dr. Noela Invernizzi RELANS

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1 Mapping of Advanced Materials Deployment for Societal Changes: Nanomedicine in Latin America Dr. Noela Invernizzi RELANS NMP-DeLA Expert Workshop 19 th 20 th May, 2014

2

3 Nanotechnology in the S&T agendas of selected Latin American countries Year Country Institution 2000 Brazil Ministry of Science and Technology 2001 Mexico National Council for Science and Technology 2003 Argentina Science and Technology Secretariat 2004 Colombia Administrative Department for Science, Technology and Innovation 2004 Costa Rica National Council for Scientific and Technological Research 2005 Guatemala National Council for Science and Technology 2005 Ecuador National Secretariat for Science and Technology 2006 El Salvador National Council for Science and Technology 2006 Peru National Council for Science, Technology and Innovation Technology 2008 Dominican Rep. State Secretariat for Higher Education, Science and Technology 2009 Uruguay Ministerial Advisory Office for Innovation 2010 Panama National Secretariat for Science, Technology and Innovation

4 Methodology: Selected countries and data sources Countries Latin America Brazil Mexico Argentina Chile Colombia Uruguay Data Source Web of Science & Scopus Research Centers Web pages Call for projects (MCTI, Conacyt, Colciencias, and others) C&T Agencies Web Pages (Conacyt, Promep, CNPq, Colciencias, ANII ): research groups, researchers CVs Networks and professional associations Bibliographic material Nanotechnology companies databases Personal knowledge

5 Brazil Funded research projects on nanomedicine : 61 research projects on nanomedicine funded by MS&T and M. of Health Three of the 122 National Institutes of Science and Technology (MS&T) on nanomedicine: Nat. Inst. of NanoBioPharmaceutics Nat. Inst. of Nanobiotechnology Nat. Inst. of Nanobiostructures & Nanobiomolecular Simulation

6 Brazil: 77 CNPq Research Groups on nanomedicine Note: Some Groups research on more than one area

7 Brazil Important Laboratories on nanomedicine NanoSUS Fiocruz/IBMP, Curitiba, PR. The only lab of the SISNANO on health. Goal: to develop, validate and produce prototypes of nanobiotechnological processes and products for the National Health System (SUS) Institute of Technology in Pharmaceuticals (Farmanguinhos). Rio de Janeiro, RJ. larger public laboratory of the Ministry of Health produces more than one billion of medicines each year for the SUS Researching on drugs and drug delivery systems for esquistomosse and HIV Laboratory of Nanomedicine and Nanotoxicology. São Carlos, SP. functionalized nanoparticles for imaging, drug delivery and new drugs new materials for detection of biological substances and biosensors for diagnostics toxic effects of nanoparticles

8 Brazil Important Laboratories on nanomedicine Center for Nanotechnology and Tissue Engineering- Riberão Preto, SP. nanostructured photo-activated drugs for skin cancer treatment produces artificial skin in considerable scale, used in the treatment of burned patients or other scare-related conditions. Distribution has not yet reached the SUS, but already in major public hospitals Planta de nanopolímeros. Rio de Janeiro, RJ. first pilot plant with capabilities for scaling-up technologies for the production of polymeric micro and nanoparticles with applications in the medical, biotechnology and pharmaceutical areas. Production of Praziquantel (PZQ) developed by Farmanguinhos.

9 Brazil Firms with activities on nanomedicine 2012: 29 Firms in the health sector (out of 155) 16 pharmaceutical 13 other medical materials & devices

10 Mexico Conacyt funded research projects on nanomedicine projects funded. Mainly through Conacyt-Basic research calls.

11 Mexico Secretary of Education s PROMEP Academic Clusters in public universities (except UNAM) Total: 20 ACs distributed among 14 universities Main areas: - polymer materials and metallic particles (17 ACs). - Diagnosis (2 ACs) - Other (1 AC)

12 Mexico UNAM Research Centers in nanomedicine CNyN. Centro de Nanociencias y Nanotecnología - diabetes IBT. Instituto de Biotecnología chemotherapy IFC. Instituto de Ciencias Físicas nanoparticles for medical use

13 Mexico Other relevant Research Groups in nanomedicine Conacyt Research Centers: CIAD; CIATEJ; CIQA- drugs, diagnostics and materials Cinvestav - research on of nanomaterials applied to nanomedicine and toxicology of nanoparticles. Instituto Politécnico Nacional: CICATA-L, CIC, ENCB, ESM, UPIBI, UPIITA different areas of nanomedicine (not specified).

14 Mexico Other relevant Research Groups in nanomedicine National Research Centers: Neuroscience and Neurosurgery National Institute (INNyN) new materials for drug delivery National Institute of Cancer Research -diagnosis Mexican Institute of Social Security - new diagnosis methods for cancer and other diseases Hospital Juárez de México not specified Instituto Nacional de Investigaciones Nucleares - diagnosis

15 Mexico Important Laboratories on nanomedicine Centro Nacional de Investigación en Imagenología e Instrumentación Biomédica (CI3M) UAM-I Laboratorio de Nanotecnología Aplicada a la Medicina (UAM-X & INNN)- Neuroscience and Neurosurgery National Institute

16 Mexico Firms with activities on nanomedicine 2012: 6 Firms in nanomedicine (out of 101 in nanotechnology). Medical and Dentistry supplies (2) Biomedical (2) Pharmaceutical (2)

17 Argentina 21 Research Groups on nanomedicine (FAN) Diagnostics Other issues/ Drugs and Therapies Toxicology 2 Biomaterials Note: Groups may work on more than one area 7 5 Regenerative Medicine 9 Drug Delivery and Vaccines Source: FAN

18 Argentina Nanomedicine Association Nanomedicine researchers are organized in the Argentinean Association for Nanomedicine. Includes several universities, research centers and hospitals throughout the country Organized several Nanomedicine Schools and meetings. Main research topics covered: drugs and therapies, drug delivery, materials, and regenerative medicine, diagnosis

19 Argentina Main Public Laboratories Targeting of drugs, Universidad de Quilmes, Prov. Bs As Laboratory of Engineering of Tissues, Regenerative Medicine and Cellular Therapies, Prov. Bs As.

20 Argentina Firms with activities in nanomedicine FAN identified 3 companies using nanotechnology in the pharmaceutical sector, among a total of 46 nanotechnology companies

21 Chile Research Projects funded by (Conicyt) Institution Universidad de Chile. Centro para la Investigación Interdisciplinaria Avanzada en Ciencia de los Materiales (CIMAT). Research topic Magnet Nanoparticles to treat cancer and Alzheimer's Universidad de Chile Centro de Estudios Avanzados de Enfermedades Crónicas (ACCDiS) Treatment and prevention of chronic diseases Universidad de Chile Universidad de Santiago de Chile. Centro para el Desarrollo de la Nanociencia y la Nanotecnología (Cedenna) Polymeric materials and metallic particles Transport and characterization of fluids in arteries and brain aneurysms

22 Chile Research Projects funded by (Conicyt) Institution Universidad de Santiago de chile. Facultad de Química y Biología Pontificia Universidad Católica de Chile. División de Obstetricia y Ginecología de la Escuela de Medicina Universidad Andrés Bello. Departamento de Ciencias Químicas Research topic Plásticos como transportadores de fármacos con liberación programada Hipertensión arterial Nanopartículas antibacteriales Universidad Andrés Bello. Departamento de Ciencias Químicas Universidad de Talca, Centro de Bioinformática y Simulación Molecular. & Instituto Fraunhofer Gesellschaft, Alemanha, Detección temprana del cáncer por nanopartículas Tratamiento para el Cáncer

23 Colombia Nanomedicine research 1 group in nanomedicine (out of 10 on nanotechnology) within the Colciencias Web search machine. Location: Universidad Javeriana Main research topic: cancer Firm: Clinic Shaio: research on Mems/Nems for pacemakers

24 Uruguay Research Groups Institution Lab./ Department Topic Facultad de Ciencias, Univ.de la República Laboratorio de Radiofarmacia - Centro de Investigaciones Nucleares (CIN) Diagnosis Drug delivery Facultad de Ciencias, Univ. De la República Facultad de Química & Centro Nanomat, Univ. de la República Facultad de Odontología, Univ. de la República Instituto de Investigaciones Biológicas Clemente Estable Instituto Pasteur de Montevideo Universidad ORT Laboratorio de Biomateriales / Instituto de Química Biológica. Cátedra de Física/Laboratorio de Cristalografía/Centro NanoMat - DETEMA Cátedra de Fisiología Laboratorio de Señalización Celular y Nanobiología /Div. Neurociencias. Laboratorio de Neurodegeneración Facultad de Ingeniería. Laboratorio de Biotecnología Biomaterials Diagnosis Regenerative medicine Drugs and therapies Biomaterials Diagnosis Biomaterials Drugs and Therapies Diagnosis. Source: ANII, C. Vitaes

25 Nanomedice Research Groups in LA main research topic Country Total of Research Groups Diagnosis Drugs & Therapy Regenerative medicine Materials & techniques Other/ unknown Brazil Mexico Argentina Colombia Chile Uruguay Total %

26 Conclusions (1) 1. Funding for nanomedicine research is mainly public in all countries. 2. Great inequality among countries: research infrastructure, funding and human capabilities. 3. Basic research in most cases. 4. Considerable amount of research directed to global heath challenges (e.g. cancer).

27 Conclusions (2) 5. Initial steps towards applied research through Public Research Centers and Public Health Care Institutions Brasil Fiocruz, Farmanguinhos; México - Secretaría de Salud Argentina Cucaiba, Ministerio de Salud, Prov. De Buenos Aires

28 Thank you

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