Integrated SPR Biosensor system for smart WSN Rémi, VINCENT, WP2 DEMO5

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1 Rémi, VINCENT, WP2 DEMO5

2 Biosensor Emerging Biosensor Market: One of the fastest growing sectors in the worlds 10 $billion Market (2012) expected to grow at over 9% The total biosensors market showing the world revenue forecast for * Digest Journal of Nanomaterials and Biostructures Vol. 7, No. 4, October-December 2012, p

3 Optical Biosensor: Surface Plasmon Resonance (SPR) Chip (OSNC, LICB) Shift of The plasmon Resonnance Improve the sensibility of optical sensor for the detection of selected analytes (ppm) Analytes Reflectivity Metallic layer Evanescente Wave affinity ligand Wavelength or angle of incidence System software SPW Sensorgram Incoming Beam Incidence Angle Reflected Beam 3

4 Work packages / project status (LNIO, ICD) Project starting date: 15/02/13. Anticipating a 3 year duration Work in progress: Objectives: Optimization and integration of an ultra compact spectrometer for the realization of nano-bio-captors networks for real time sensors Prototyping Lambdameter with reported Camera Replace the imager system (Objective + lens tube + CCD) by a CCD placed very close to the surface of the prism Cobiss spectrometer, Patent n WO Prototyping/Demonstrator: SPR-sensor for liquid phase: CoBiSS + microfluidic cell 4

5 Sensor technology can be adapted to meet various requirements Packaging and collection system can be adapted for: Continuous air monitoring: Airborns particles, Hydrocarborns, CO, CO2, NO2, CH4, Continuous monitoring of water systems : Bisphenol A, Pb2+, CH4, PCBs, Herbicide Lyon/Geneva, 17 October 2013 The specialized cancer agency of the World Health Organization, the International Agency for Research on Cancer (IARC), announced today that it has classified outdoor air pollution as carcinogenic to humans (Group 1). Food monitoring, Bacteries (Salmonella, Listeria ans Shiga-Toxin Escherichia coli) Portable environmental monitoring: Cholesterol,.. Toxin detection, biodefense: Anthrax, Real-time industrial risk monitoring Analyte Gas/vapor Exposure limit, 8 hr (ppm) Exposure limit, 10 mn (ppm) H 2 S CO NOx, NO

6 Potential application : Smart Sensor network for environmental monitoring Continuous air monitoring SPR chip Continuous monitoring of water systems Control over large Area Control center Cobiss spectrometer, Patent n WO Integrated SPR Biosensor system 6

7 Potential application : Smart Wireless network Sensor (WSN) For environmental monitoring (LM2S, Prof. H. SNOUSSI) Objectives : Cooperative sensor network robustness of the global decision-making Traitement du signal Décision statistique Diagnostic des systèmes Intégration électronique Capteurs optiques Fiabilité des capteurs Ordonnancement des activités Optimisation de la couverture Algorithmes de routage Codage distribué et collaboratif Accès multiple Impact des erreurs canal 7

8 State of the art Our strengths Selectivity, sensibility, versatility, robustness (no mechanical part) Integration Temperature insensitive (metallic nanocrystals LSPR substrate) Fast time processing Liquid phase, gas phase Wireless Network Cobiss spectro Intensity Angle Wavelength Phase Resolution (dn/n) 10-5 RIU RIU 10-6 RIU RIU Challenges or scientific/technological bottlenecks Price, interdisciplinary fields, energy consumption 8

9 Project resources Interdisciplinary Team More than ten collaborators Industrial partner Prestodiag device (AAP ANR ASTRID) Detecting bactery in growing phase in few hour! Biogaz valley (ANR AutoFERME 2014) Academic partner OSNC/ICB (Dijon): innovative fabrication technic for nanocristal metallic substrate, and Surface Chemistry for SPR (Surface Plasmon Resonance) LNIO/ICD (Troyes): Nanofabrication, optical measurment, integration and prototyping LM2S/ICD(Troyes): Networking, detection, and network signal analysis. 9

10 Perspectives Up to our knowledges a system integrating all the functionality we propose to develop is new, and neither commercial or prototyped Major publications and Recent Patents [1] Nature Photonics - 1er août "Wavelength-scale stationary-wave integrated Fourier transform spectrometry : SWIFTS", E. Le Coarer, S. Blaize, P. Benech, I. Stefanon, A. Morand, G. Lérondel, G. Leblond, P. Kern, JM. Fedeli, P.I Royer [2] Y. Hadjar, S. Blaize, A. Bruyant, G. Lerondel and P. Royer, «Spectromètre à Echantillonnage Bidimensionnel», Brevet WO 2009/ A1 [3] Y. Hadjar, M. Renault, S. Blaize, A. Bruyant, «Dispositif interférométrique et spectromètre correspondant», Brevet Français No , filed 06/06/

11 Thanks for your attention Rémi VINCENT Tenure Track Researcher at the LNIO

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