IWK September 22, Cord Blood Program

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1 IWK September 22, 2010 Cord Blood Program

2 Discussion Topics Insception s core values and core purpose Insception s experience Umbilical Cord Blood Stem cell Uses Insception Services in a Hospital Partnership Benefits Next Steps

3 Core Values and Purpose Core Values commitment to the highest quality commitment to the patient and community commitment to teamwork commitment to innovation commitment to integrity and ethics Core Purpose to enable advancements in the use of stem cells for treating disease and developing regenerative therapies

4 Cord Blood Banking Experience 15 years ( ) Moved to purpose built lab in Mississauga in 2004 Mississauga lab has capacity and lease for 10 years plus beyond ,000 cord blood units banked 25,000 families Partnership with Mount Sinai Hospital

5 Experience 11 CBU released to transplant (HSC) 7 CBU released to regenerative therapy trials in CP and Type 1 Diabetes More releases than all competitors combined Oldest released CBU is 11 years viability as good as when collected Highest quality lab and outstanding quality management system AABB, Health Canada, FDA Registered

6 Experience Medical Need Program has benefitted 250 families Feldberg Fund benefits 10 families a year Founders engaged and supported in stem cell research Mount Sinai Hospital and Scientific founder contribute to excellent Board of Director governance. Insception Public Cord Blood Program- Not-for-Profit initiative providing Cord Blood stem cells to those in need. Will be available Fall 2010.

7 Probability of Use 1999 Today It has been estimated that the use of autologous cord blood is 1:20,000 collections. (Annas. NEJM. 1999) CIBMTR data indicate that in the U.S the lifetime probabilities are 1:400 and 1:200 respectively for undergoing allogenic HSCT or either autologous or allogenic HSCT. (Nietfield, Pasquini. American Society for Blood and Marrow Transplantation 2008) Almost 1 in 3 individuals could potentially benefit over their lifetime from regenerative medicine (Harris BJH 2009)

8 Cord Blood Uses Today Over 20,000 cord blood transplants worldwide treating over 75 diseases including: Marrow Failure syndromes Hemoglobinopathies Blood disorders Malignancy/Blood cancers Immunodeficiencies

9 Emerging and Potential Uses Juvenile Diabetes Cerebral Palsy Spinal Cord Injury Heart Disease Brain Injury, Stroke Organ regeneration Multiple sclerosis ALS United Cerebral Palsy. Cerebral Palsy - Facts & Figures. Accessed: April

10 CB Program Services Support for Patient and Community Parent information sessions on site L&D lunch and learns on site Pre-natal education participation on site Support for Health Care Providers and IWK Clinical research and trial updates Quarterly quality reports Quarterly financial reports Multi-specialty Grand rounds

11 Insception s CB Program Services Medical Need Program Financial Need program development Payment Terms Collection kits on site (and consistent) L&D Process consistency Sustainable growing revenue stream

12 Hospital Partnership deliverables Preferred Provider status Co-branding (web site, publications) Access to onsite room for Education Support from IWK management with OBs, Family medicine and nursing staff Feedback and reporting

13 Benefits of Partnering with Insception Cord Blood Program Support Providing access for Patients Education for Healthcare Providers Collaborate to Increase awareness in the community Consistency Collection kits and process allows better collection Clear common message for patients Simplicity Quarterly payment with itemized reports Sustainable Growing Revenue Stream Provide financial support for departments, programs and services Reputation Canada s largest and most experienced Family Cord Blood Program Quality Organization

14 Wings of Hope- Medical Need Compassionate support to families dealing with conditions that might potentially lead to the need of a stem cell transplant in an immediate family member Over 250 families have participated, number is growing Insception waived the processing and initial fees Insception has contributed over $275,000 4/18 of our transplants are through Wings of Hope Largest initiative of its kind in Canada

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