Aktuelle Publikationen

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1 Aktuelle Publikationen Beobachtungsstudien Interventionsstudien Investigator initiierte Anwendungsbeobachtungen der Phase I (Bench to bedside) Metaanalysen und Evidenz-basierte Leitlinien Arbeiten zur Studienmethodik Beobachtungsstudien Hepcidin concentrations in serum and urine correlate with iron homeostasis in preterm infants. Müller KF, Lorenz L, Poets CF, Westerman M, Franz AR. J Pediatr Jun;160(6): e2. Celebi N., Tsouraki R., Engel C., Lammerding-Köppel M., Baur P., Riessen R., Weyrich P. (2012): Does doctors workload impact the supervision and ward activities of final-year medical students? A prospective study. BMC Biomedical Education 12:24. Gröschel, S., Kehrer, C., Engel, C., idali, C., Bley, A., Steinfeld, R., Grodd, W., Krägeloh- Mann, I. (2011): Metachromatic leukodystrophy: natural course of cerebral MRI changes in relation to clinical course. Journal of Inherited Metabolic Disease, DOI /s Armbruster J, Schmidt B, Poets CF, Bassler D. Nurses'compliance with alarm limits for pulse oximetry: qualitative study. J Perinatol doi: /jp Gloria Herrmann, Liang Yang, Hong Wu, Zhijun Song, Hengzhuang Wang, Niels Høiby, Riethmüller Joachim, Martina Ulrich, Søren Molin and Gerd Döring. Colistin/tobramycin combinations are superior to monotherapy concerning the killing of biofilm P. aeruginosa. J Infect Dis Nov 15;202(10): Becker Katrin Anne*, Joachim Riethmüller*, Anja Lüth*, Gerd Döring, Burkhard Kleuser, Erich Gulbins. Inhalation of acid sphingomyelinase inhibitors normalizes ceramide and inflammation in cystic fibrosis. Am J Respir Cell Mol Biol Jun;42(6): Martina Ulrich, Isabelle Beer, Peter Braitmaier, Michaela Dierkes, Florian Kummer, Bernhard Krismer, Ulrike Schumacher, Ute Gräpler-Mainka, Joachim Riethmüller, Peter Ø. Jensen, Thomas Bjarnsholt, Niels Høiby, Gabriel Bellon, Gerd Döring. Relative contribution of Prevotella intermedia and Pseudomonas aeruginosa to lung pathology in airways of cystic fibrosis patients. Thorax 2010; 65: Franz AR, Pohlandt F, Bode H, Mihatsch WA, Sander S, Kron M, Steinmacher J. Intrauterine, early neonatal, and postdischarge growth and neurodevelopmental outcome at 5.4 years in extremely preterm infants after intensive neonatal nutritional support. Pediatrics 2009;123:e

2 Bassler D, Stoll BJ, Schmidt B, Asztalos EV, Roberts RS, CMT Robertson, RS Sauve. Using a Count of Neonatal Morbidities to Predict Poor Outcome in Extremely Low-Birth-Weight Infants: The Added Role of Neonatal Infection. Pediatrics 2009;123: Interventionsstudien Karen T, Vatlach S, Maas C, Poets A, Poets CF, Bassler D (2012) The impact of oral sucrose on apnea and bradycardia in preterm infants: a randomised crossover trial. Arch Dis Child Fetal Neonatal Ed, 2012 The 'Effects of Transfusion Thresholds on Neurocognitive Outcome of Extremely Low Birth- Weight Infants (ETTNO)'Study: Background, Aims, and Study Protocol. ETTNO Investigators. Franz AR, Maier RF, Thome UH, Rüdiger M, Kron M, Bassler D, Poets CF, Krägeloh-Mann I, Schoberer M, Trepels-Kottek S, Buheitel G, Schenk W, Bührer C, Guthmann F, Garten L, Hüseman D, Czernik C, Rossi R, Kühn T, Eilers E, Teig N, Weitkämper A, Reinholdt J, Veiergang G, Roll C, Pielemeier W, Ojinaga V, Braun N, Rüdiger M, Bittrich HJ, Roefke K, Schroth M, Topf HG, Stein A, Keller M, Hüning BM, Fischer D, Buxmann H, Heckmann M, Faas D, von der Wense A, Gudowius P, Kabisch S, Hillebrand G, Bohnhorst B, Peter C, Urlichs F, Hoppenz M, Pabst T, Kribs A, Klein RM, Hünseler C, Roth B, Vierzig A, Eifinger F, Oberthür A, Mehler K, Thome UH, Gebauer C, Knüpfer M, Maier RF, Zemlin M, Mähnhardt L, Nussbaum CF, Schwepcke A, Rellensmann G, Rieger-Fackeldey E, Schiffmann JH, Grombach J, Schäfer S, Segerer H, Keller- Wackerbauer A, Burghard R, Hubert M, Vochem M, Pohlmann U, Neuberger P, Wagner M, Franz A, Bassler D, Fuchs H, Schmid M, Hopfner R, Bucher HU, Rabe H, Högel J, Engel C, Riethmüller J. Neonatology Jan 27;101(4): Mainz J, Schiller I, Ritschel C, Mentzel HJ, Riethmüller J, Koitschev A, Schneider G, Beck J, Wiedemann B. Sinu-nasal inhalation of Dornase alfa in CF, double-blind-placebo controlled pilot-trial. Auris Nasus Larynx 2011;38: Klingberg, S., Wölwer, W., Engel, C., Wittorf, A., Herrlich, J., Meisner, C., Buchkremer, G., Wiedemann, G. (2011): Negative Symptoms of Schizophrenia as Primary Target of Cognitive Behavioral Therapy: Results of the Randomized Clinical TONES Study. Schizophrenia Bulletin 37 (Suppl 2), S98-110, doi: /schbul/sbr073. Celebi N., Zwirner K., Lischner U., Bauder M., Ditthard D., Schürger S., Riessen R., Engel C., Balletshofer B., Weyrich P. (2010): Student tutors are able to teach basic sonographic anatomy effectively a prospective randomized controlled trial (Ultraschall in der Med ) Brötz, D., Maschke, E., Burkard, S., Engel, C., Mänz, C., Ernemann, U., Wick, W., Weller, M. (2010): Is there a role for benzodiazepines in the management of lumbar disc prolapse with acute sciatica? Pain 149, Klingberg S., Wittorf A., Meisner C., Wölwer W., Wiedemann W., Herrlich J., Bechdolf A., Mueller BW, Sartory G., Wagner M., Kircher T., Koenig HH, Engel C. and Buchkremer G. (2010): Cognitive behavioural treatment (CBT) for persistent positive symptoms in psychotic disorders. The POSITIVE Study. A multicenter, prospective, single-blind, randomised controlled clinical trial. Trials 2010, 11:213

3 J Riethmueller, M Ballmann, TW Schroeter, P Franke, R von Butler, A Claass, S Junge, G Doering, M Stern. Tobramycin once versus thrice daily for elective intravenous antipseudomonal therapy in cystic fibrosis. Infection 2009;37: J Riethmueller, S Junge, TW Schroeter, K Kuemmerer, P Franke, M Ballmann, A Claass, S Broemme, A Hebestreit, H Hebestreit, D Staab, K Koetz, G Doering, M Stern. Continuous vs thrice-daily ceftazidime for elective intravenous antipseudomonal therapy in cystic fibrosis. Infection 2009;37: Joachim Riethmueller, Matthias Kumpf, Thomas Borth-Bruhns, Wolfgang Brehm, Jakub Wiskirchen, Michael Hofbeck, Winfried Baden. Dornase alfa therapy in mechanically ventilated pediatric non-cystic fibrosis patients with atelectases. Cell Physiol Biochem 2009;23: Riethmueller J, Janina Anthonysamy, Emilio Serra, Matthias Schwab, Gerd Döring, Erich Gulbins. Therapeutic efficacy and safety of amitriptyline in patients with cystic fibrosis. Cell Physiol Biochem 2009;24:65-72 Wick, W., Hartmann, C., Engel, C., Stoffels, M., Felsberg, J., Stockhammer, F., Sabel, M.C., Koeppen, S., Ketter, R., Meyermann, R., Rapp, M., Meisner, C., Kortmann, R., Pietsch, T., Wiestler, O.D., Ernemann, U., Bamberg, M., Reifenberger, G., von Deimling, A., Weller, M. (2009): NOA-04 ranodmized phase III trial of sequential radiochemotherapy of anaplastic glioma with procarbazine, lomusitine and vincristine or temozolomide. Journal of clinical oncology 27, 1-9. Feudner, E., Engel, C., Neuhann, I., Petermeier, K., Bartz-Schmidt K.-U., Szurman, P: (2009): Virtually reality training improves wet-lab performance of capsulorhexis: results of a randomized, controlled study. Graefes Arch Clin Exp. Ophthalmol 247, Plontke, S.K., Löwenheim, H., Mertens, J., Engel, C., Meisner, C., Weidner, A., Zimmermann, R., Preyer, S., Koitschev, A., Zenner, H.-P. (2009): Randomized, double blind, placebo controlled trial on the safety and efficacy of continous intratympanic dexamethasone delivered via a round windom catheter for severe to frofound sudden idiopathic sensorineural hearing loss after failure of systemic therapy. Laryngoscope 119, Riethmueller J, M Ballmann, TW Schroeter, P Franke, R von Butler, A Claass, S Junge, G Doering, M Stern. Tobramycin once versus thrice daily for elective intravenous antipseudomonal therapy in cystic fibrosis. Infection 2009;37: Riethmueller J, S Junge, TW Schroeter, K Kuemmerer, P Franke, M Ballmann, A Claass, S Broemme, A Hebestreit, H Hebestreit, D Staab, K Koetz, G Doering, M Stern. Continuous vs thrice-daily ceftazidime for elective intravenous antipseudomonal therapy in cystic fibrosis. Infection 2009;37: Bassler D, Halliday HL, Plavka R, Hallman M, Shinwell ES, Jarreau PH, Carnielli V, van den Anker J, Schwab M, Poets CF. The Neonatal European Study of Inhaled Steroids (NEUROSIS): An EU-Funded International Randomised Controlled Trial in Preterm Infants. Neonatology. 2009;97:52-55.

4 Investigator initiierte Anwendungsbeobachtungen der Phase I (Bench to bedside) Herrmann G, Yang L, Wu H, Song Z, Wang H, Høiby N, Riethmüller J, Ulrich M, Molin, Döring G. Colistin/tobramycin combinations are superior to monotherapy concerning the killing of biofilm P. aeruginosa. The Journal of Infectious Diseases; accepted for publication Ulrich M, Beer I, Braitmaier P, Dierkes M, KummerF, Krismer B, Schumacher U, Gräpler- Mainka U, Riethmüller J, Jensen P, Bjarnsholt T, Høiby N, Bellon G, Döring G. Relative contribution of Prevotella intermedia and Pseudomonas aeruginosa to lung pathology in airways of cystic fibrosis patients. Thorax 2010; accepted for publication Metaanalysen und Evidenz-basierte Leitlinien Meerpohl JJ, Antes G, Rucker G, Fleeman N, Motschall E, Niemeyer CM, Bassler D (2012) Deferasirox for managing iron overload in people with thalassaemia. Cochrane Database Syst Rev:CD Alfaleh K, Anabrees J, Bassler D, Al-Kharfi T (2011) Probiotics for prevention of necrotizing enterocolitis in preterm infants. Cochrane Database Syst Rev:CD Bassler D, Kreutzer K, McNamara P, Kirpalani H (2010) Milrinone for persistent pulmonary hypertension of the newborn. Cochrane Database Syst Rev:CD Meerpohl JJ, Antes G, Rucker G, Fleeman N, Niemeyer C, Bassler D (2010) Deferasirox for managing transfusional iron overload in people with sickle cell disease. Cochrane Database Syst Rev:CD Briel M, Ferreira-Gonzales I, You JJ, Karanicolas PJ, Akl EA, Wu P, Blechacz B, Bassler D, Wie X, Sharman A, Whitt I, Alves da Silva S, Khalid Z, Nordmann AJ, Zhou Q, Walter SD, ValeN, Bhatnagar N, O'Regan C, Mills EJ, Bucher HC, Montori VM, Guyatt GH. Association between change in high-density lipoprotein cholesterol and cardiovascular disease morbidity and mortality: a systematic review and meta-regression analysis. BMJ. 2009;338:b92. doi: /bmj.b92. Vanderveen JA, Bassler D, Robertson CM, Kirpalani H (2009) Early interventions involving parents to improve neurodevelopmental outcomes of premature infants: a meta-analysis. J Perinatol, 29: Arbeiten zur Studienmethodik Guyatt GH, Briel M, Glasziou P, Bassler D, Montori VM., Problems of stopping trials early. BMJ Jun 15;344:e3863. doi: /bmj.e3863. Akl EA, Sun X, Busse JW, Johnston BC, Briel M, Mulla S, You JJ, Bassler D, Lamontagne F, Vera C, Alshurafa M, Katsios CM, Mills E, Guyatt GH (2012) Specific instructions for

5 estimating unclearly reported blinding status in randomized trials were reliable and valid. J Clin Epidemiol, 65:262-7 Akl, EA, Briel M, You JJ, Sun X, Johnston BC, Busse JW, Mulla S, Lamontagne F, Bassler D, Vera C, Alshurafa M, Katsios CM, Zhou Q, Cukierman-Yaffe T, Gangji A, Mills EJ, Walter SD, Cook DJ, Schünemann HJ, Altman DG, Guyatt GH (2012) LOST to follow-up Information in Trials (LOST IT): Potential impact on estimated treatment effects. BMJ, 2012 Ellenberg S, Fernandes RM, Saloojee H, Bassler D, Askie L, Vandermeer B, Offringa M, Van der Tweel I, Altman DG, van der Lee JH (2012) Standards for child health trial design, conduct and reportin, STANDARD 3: Data Monitoring Committees. Pediatrics, 2012 Van der Tweel I, Askie L, Vandermeer B, Ellenberg S, Fernandes RM, Saloojee H, Bassler D, Offringa M, Altman DG, van der Lee JH (2012) Standards for child health trial design, conduct and reportin, STANDARD 4: Adequate sample sizes. Pediatrics, 2012 Sun X, Briel M, Busse JW, You JJ, Akl EA, Mejza F, Bala MM, Bassler D, Mertz D, Diaz- Granados N, Vandvik PO, Malaga G, Srinathan SK, Dahm P, Johnston BC, Alonso-Coello P, Hassouneh B, Walter SD, Heels-Ansdell D, Bhatnagar N, Altman DG, Guyatt GH (2012) Credibility of claims of subgroup effects in randomised controlled trials: systematic review. BMJ, 344:e1553 Sun X, Briel M, Busse JW, You JJ, Akl EA, Mejza F, Bala MM, Bassler D, Mertz D, Diaz- Granados N, Vandvik PO, Malaga G, Srinathan SK, Dahm P, Johnston BC, Alonso-Coello P, Hassouneh B, Truong J, Dattani ND, Walter SD, Heels-Ansdell D, Bhatnagar N, Altman DG, Guyatt GH (2011) The influence of study characteristics on reporting of subgroup analyses in randomised controlled trials: systematic review. BMJ, 342:d1569 Bassler D, Montori VM, Briel M, Glasziou P, Walter SD, Ramsay T, Guyatt G (2011) Reflections on meta-analyses involving trials stopped early for benefit: Is there a problem and if so, what is it? Stat Methods Med Res [Epub ahead of print] Bassler D, et al. Stopping randomized trials early for benefit and estimation of treatment effects: systematic review and meta-regression analysis. JAMA. 2010;303: Sun X, Briel M, Busse JW, Akl EA, You JJ, Mejza F, Bala M, Diaz-Granados N, Bassler D, Mertz D, Srinathan SK, Vandvik PO, Malaga G, Alshurafa M, Dahm P, Alonso-Coello P, Heels-Ansdell DM, Bhatnagar N, Johnston BC, Wang L, Walter SD, Altman DG, Guyatt GH. Subgroup Analysis of Trials Is Rarely Easy (SATIRE): a study protocol for a systematic review to characterize the analysis, reporting, and claim of subgroup effects in randomized trials. Trials. 2009;10:101. Akl EA, Briel M, You JJ, Lamontagne F, Gangji A, Cukierman-Yaffe T, Alshurafa M, Sun X, Nerenberg KA, Johnston BC, Vera C, Mills EJ, Bassler D, Salazar A, Bhatnagar N, Busse JW, Khalid Z, Walter S, Cook DJ, Schünemann HJ, Altman DG, 9.Guyatt GH. LOST to follow-up Information in Trials (LOST-IT): a protocol on the potential impact. Trials. 2009;10:40.

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