Welcome to the 10 th LURN retreat. March 20 21, Ystad Saltsjöbad, Ystad

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1 Welcome to the 10 th LURN retreat March 20 21, 2013 Ystad Saltsjöbad, Ystad

2 Organizing Committee: Gunilla Westergren Thorsson, Leif Bjermer, Kristina Rydell Törmänen, Jenny Karlsson, Marianne Person and Agneta Hult Programme coordinator: Kristina Rydell Törmänen Supported by: The Sandberg foundation, The Swedish Research Council (VR) and InterMune The Sandberg foundation is represented by: Per Sandberg Håkan Westling Previous years Honorary Sandberg Lecturates: 2011 Professor Dirkje Postma, University of Groningen, the Netherlands 2012 Professor James C Hogg, icapture Center, St. Paul s Hospital, VA, Canada Previous years Sandberg Prize Award: 2011 Professor Anders Eklund and Professor Johan Grunewald, Karolinska Institutet, Sweden 2012 Professor Thomas Sandström and Professor Anders Blomberg, Umeå University, Sweden 1

3 DAY 1. WEDNESDAY 20 TH MARCH Arrival and Coffee Break Session A Lund Respiratory Network - LURN Introduction to LURN Professor Gunilla Westergren-Thorsson, PhD The history and progress of LURN Professor Leif Bjermer, MD, PhD Sandberg Awardees, Young Investigators and Honorary Sandberg lecturers Professor Claes-Göran Löfdahl, MD, PhD Session B Rare and Orphan Diseases CHAIRMEN: HAMID AKBARSHAHI, MD, PHD AND KRISTINA RYDELL-TÖRMÄNEN, PHD Karin Tran Lundmark, MD, PhD (Lund University, Lund, Sweden) Pulmonary hypertension - with focus on growth factors and extracellular matrix Discussion Erik Eklund, MD, PhD (Lund University Hospital, Lund Sweden) Gorham-Stout disease - sometimes an osteoclastic lung disease? Discussion Gunnar Norstedt, MD, PhD, (Karolinska Institutet, Stockholm, Sweden) Potential role of prolactin signaling in lymphangioleiomyomatosis (LAM) Discussion Lunch Session C Asthma, Allergy and Inflammation CHAIRMEN: SARA ROLANDSSON AND CECILIA ANDERSSON, PHD Andrew N. McKenzie, PhD (University of Cambridge, Cambridge, UK) Type-2 innate lymphoid cells (ILC2) in protective immunity and allergy Discussion Maria Weitoft Lundström (Lund University, Lund, Sweden) Altered turnover and composition of extracellular matrix in patients with uncontrolled asthma Discussion 2

4 Anders Bergqvist (Lund University, Lund, Sweden) Alveolar Th2 inflammation in uncontrolled asthma Discussion Professor Zuzana Diamant, MD, PhD (Lund University, Lund, Sweden and UMCG (Dept. of General Practice) & QPS-NL, Biotech Centre, Groningen, The Netherlands) Allergen challenge in clinical asthma research Discussion Coffee Break Session D Matrix as a Culprit in Pulmonary Disease CHAIRMEN: JENNY CALVÉN AND ANNIKA ANDERSSON-SJÖLAND, PHD Professor Dr. Oliver Eickelberg, MD, PhD (Ludwig-Maximilians-Universität and Helmholtz Zentrum, Munchen, Germany) Early stages of lung fibrosis Discussion Christina Wenglén, PhD (AnaMar, Lund, Sweden) Novel 5-HT 2 receptor antagonists as potential inhibitors of lung fibrosis Discussion Professor Kristofer Rubin, PhD (Lund University, Lund Sweden) TGF-beta and the matrix interactions in tumor stroma Discussion Session E Poster Presentation Committee will be circulating amongst the posters and talking to presenters Posters will be on display during the rest of the retreat Dinner 3

5 DAY 2 THURSDAY 21 ST MARCH Session F - Pulmonary Immune Responses and Immune Remodeling CHAIRMEN: MICHIKO MORI AND ANNA-KARIN LARSSON-CALLERFELT, PHD Professor Pieter S. Hiemstra, PhD (Leiden University, Leiden, The Netherlands) Respiratory host defense and inflammation Discussion Professor Jonas S. Erjefält, PhD (Lund University, Lund, Sweden) Immune remodeling: a new aspect of COPD pathology Discussion Sandra Jovic (Lung University, Lund, Sweden) P. aeruginosa counteracts the host defence system in cystic fibrosis Discussion Coffee Break and Check Out Session G Determinants of Disease CHAIRMEN: MARIAM BAGHER AND ELLEN TUFVESSON, PHD Professor Guy G. Brusselle, MD, PhD (Ghent University Hospital and Ghent University, Ghent, Belgium) Genetic and epigenetic markers of COPD development Discussion Oskar Hallgren, PhD (Lund University, Lund, Sweden) Serine and arginine-rich splicing factors as nuclear targets for TGF-b dependent alternative splicing Discussion Dirk Wuttge, MD, PhD (Lund University, Lund, Sweden) Initiation of pulmonary alterations in systemic sclerosis Discussion 4

6 Johan Staaf, PhD (Lund University, Lund, Sweden) Genomic techniques for analysis of lung cancer genomes Discussion Jill R Johnson, PhD (Imperial College, London, UK) Pericyte mobilization contributes to remodeling in allergic airways disease Discussion Lunch Session H Sandberg lecturers 2012 Professor Gunilla Westergren-Thorsson Sandberg lecturers Stories of 4 successful researchers Young Investigator Awardees Professor Gunilla Westergren-Thorsson Concluding remarks Professor Leif Bjermer Coffee and Departure 5

7 Participants LURN mars 2013 Suado Abdillahi Lund University Lund Hamid Akbarshahi Lund University Lund Cecilia Andersson Lund University Lund Annika Andersson Sjöland Lund University Lund Mariam Bagher Lund University Lund Anders Bergqvist Lund University Lund Leif Bjermer Lund University/SUS Lund Angelica Brandelius Lund University Lund Guy Bruselle Ghent University Belgium Jenny Calvén Lund University Lund Zuzana Diamant Lund University Lund Oliver Eickelberg Helmholtz Zentrum München Germany Erik Eklund Lund University/SUS Lund Gunilla Ekström AnaMar AB Lund Jonas Erjefält Lund University Lund Andrea Forkert Helmholtz Zentrum München Germany Kristina Forsman Semb AstraZeneca Mölndal Helena Forsslund Karolinska Institutet Stockholm Anele Gela Lund University Lund Oskar Hallgren Lund University Lund Pieter Hiemstra Leiden University The Netherlands Hans Jürgen Hoffmann Aarhus University Denmark Hornfelt Marie AstraZeneca Mölndal Agneta Hult Lund University Lund Johanna Höijer AstraZeneca Mölndal Karin Jansner Lund University Lund Jie Ji Karolinska Institutet Stockholm Jill Johnson Imperial College London Sandra Jovic Lund University Lund Jenny Karlsson Lund University Lund Nisha Kurian AstraZeneca Mölndal Anna Karin Larsson Callerfelt Lund University Lund Bettina Levänen Karolinska Institutet Stockholm Kristina Lexmuller Lund University Lund Ulrika Lindberg Lund University/SUS Lund Kristina Lundberg Immunteknologi, LTH Lund Claes Göran Löfdahl Lund University/SUS Lund Irma Mahmutovic Persson Lund University Lund Gyorgy Marko Varga Lund University Lund Anna Mathisson AnaMar AB Lund Christopher McCrae AstraZeneca Mölndal Andrew McKenzie University of Cambridge Cambridge Anna Miller Larsson AstraZeneca Mölndal Michiko Mori Lund University Lund Matthias Mörgelin Lund University Lund Ulf Nihlén AstraZeneca Mölndal Britt Marie Nilsson Lund University Lund 6

8 Maria Nordberg AstraZeneca Mölndal Gunnar Norstedt Karolinska Institutet Stockholm Bettina Oerhle Helmholtz Zentrum München Germany Caroline Olgart Höglund Karolinska Institutet Stockholm Marianne Person Lund University/SUS Lund Marie Ramnegård AstraZeneca Mölndal Sara Rolandsson Lund University Lund Abraham Roos Lund University Lund Kristofer Rubin Lund University Lund Kristina Rydell Törmänen Lund University Lund Medya Mara Shikhagaie Lund University Lund Max Siller AnaMar AB Lund Ingrid Skog Lund University/SUS Lund Johan Staaf Lund University Lund Xanthi Stachtea Lund University Lund Karin Svensson AstraZeneca Mölndal Henning Svensson Lund University Lund Philip Tannenberg Karolinska Institutet Stockholm Lena Thiman Lund University Lund Kristofer Thörn AstraZeneca Mölndal Karin Tran Lundmark Lund University Lund Ellen Tufvesson Lund University Lund Alf Tunsäter Lund University Lund Emil Tykesson Lund University Lund Lena Uller Lund University Lund Maria Weitoft Lundström Lund University Lund Christina Wenglén AnaMar AB Lund Gunilla Westergren Thorsson Lund University Lund Elisabet Wieslander Lund University Lund Cecilia Wikell AstraZeneca Mölndal Marie Wildt Lund University/SUS Lund Cecilia Wingren AstraZeneca Mölndal Dirk Wuttge Lund University/SUS Lund Yuan Xu Karolinska Institutet Stockholm Xiao Hong Zhou AstraZeneca Mölndal Ida Åberg Lund University Lund 7

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