4 EDUCATION: Georgia Institute of Technology, Atlanta, GA August 2006 December 2007 M.S. Bioinformatics. Concentration: Molecular Modeling Graduate Research: Performed simulation and analysis of various Apolipoprotein A-I mutants. Apolipoprotein A-I protein involved in lipid transport. Performed analysis of favorable alignments of antiparallel protein helices. Analysis was performed by varying rotational alignment of helices relative to each other and assigning a score based on alignment of charged amino acids. Rotation and scoring of alignments was performed using self-written Perl script. Resulting optimal alignment was artificially induced by amino acid substitution at position 129 by replacing Glycine amino acid with Cysteine and forming a disulfide bond between Cysteines of protein helices. Project included setting up initial model of G129C ApoA-I with lipids using Insight II molecular design software. Setting up scripts to run the energy minimization and molecular dynamics simulations. Running scripts using NAMD molecular dynamics simulation software. Analysis of simulation result, RMSD and free energy plotting using VMD visual molecular dynamics software. Simulations were performed on dual processor PC notebook, 12 processor Silicone Graphics cluster and 2042 processor IBM BlueGene cluster. Relevant Graduate Level Courses: Computer Sc. for Bioinformatics, Macromolecular Structure, Molecular Modeling, Biochemistry II, Quantum Mechanics, Scientific Visualization, Database Systems. Virginia Polytechnic Institute and State University, Blacksburg, VA August 2003 May 2006 B.S. Computer Science; Minors: Biology, Mathematics. Undergraduate Research: Participation in implementation of Web server software that determines the location of hydrogen atoms in macromolecules. Primary task involved testing of the application. Close involvement in a project, the goal of which was to determine the effect of the mrna s secondary structure on the efficiency of its degradation in the process of RNA interference. Main tasks involved writing and running small scripts in Perl as well as C++ programs to sort through data and make sense of the results; utilization of Vienna RNA secondary structure package and FASTA format data. Work was performed in UNIX as well as MS Windows environments. Relevant Courses: Chemistry I & II with labs, Molecular Biology with lab, Molecular Genetics, Genomics, Intro to Computational Biology, Computational Biology for Bioinformatics, Object Oriented Design and other computer science courses. Northampton Community College, Bethlehem, PA September 1999 May 2001 CSC Institute, Southampton, PA July July 1998
5 Advanced Visual Basic Programming Concepts, MS SQL Server, Oracle and MS Office. Diploma in Computer Programming. Riga Technology College Fortech, Riga, Latvia December May 1997 Fundamentals of Visual Basic Programming, Object Oriented Programming, Procedure Oriented Programming, Pascal, MS-DOS, Spreadsheets and data processing, Norton Utilities, Norton Commander, Norton Editor. REFERENCES: Available upon request.