1 Entering a Clinical Trial Is It Right for You? Paula Chandoha, Chandoha Productions
2 About This Program THIS AUDIOVISUAL PROGRAM AND BOOKLET WERE produced by Dana-Farber Cancer Institute in collaboration with Brigham and Women s Hospital, Massachusetts General Hospital, and the Beth Israel Deaconess Medical Center. They are for use by the Dana-Farber/Harvard Cancer Center and other institutions that offer cancer clinical trials. Funding for the production of this program was provided by the National Institute of Health (NIH) Human Subjects Research Enhancements Program. We thank the patients, family members, and hospital staff members who generously volunteered their time to participate in this program. They described unique experiences in their own words, and their insights provided the core of the program. As we were putting together the program, we talked with patients, family members, health care providers, and others who offered differing points of view. These conversations helped us see that there were sections that required clearer descriptions and new topics that needed to be covered. They also helped us balance our description of the pros and cons of cancer clinical trials.
3 Committees that offered critical suggestions include the: Office for the Protection of Research Subjects Dana-Farber/Harvard Cancer Center Research/Program Nurse Council Dana-Farber Cancer Institute Department of Patient Family Education Dana-Farber Cancer Institute Patient and Family Advisory Council Dana-Farber Cancer Institute Patient-to-Patient, Heart-to-Heart Beth Israel Deaconess Medical Center Community Engagement Committee Dana-Farber/Harvard Cancer Center Multicultural Cancer Task Force Beth Israel Deaconess Medical Center The Wellness Community Greater Boston This program and booklet are dedicated to the patients who have taken part in cancer clinical trials. Without them, new treatments for cancer could not have been developed.
4 4 ENTERING A CLINICAL TRIAL Our Goal THIS PROGRAM WAS CREATED TO EXPLAIN THE DIFFERENT types of cancer clinical trials and their purpose. Our goal is to provide information that might help you decide whether or not to take part in a trial. The booklet reviews key information from the program and contains additional questions that you may want to ask. We hope that this information is useful as you consider whether or not a clinical trial is right for you.
5 IS IT RIGHT FOR YOU? 5 Table of Contents 6 WHAT IS A CLINICAL TRIAL? 7 WHAT ARE THE PHASES OF CLINICAL TRIALS? 7 PHASE I 8 PHASE II 9 PHASE III 11 HOW ARE PATIENTS PROTECTED WHILE ON A STUDY? 11 PROTOCOL REVIEW 12 ELIGIBILITY 12 MONITORING 13 WHAT MIGHT HELP YOU DECIDE IF ENTERING A CLINICAL TRIAL IS RIGHT FOR YOU? 15 QUESTIONS YOU MIGHT ASK THE STUDY TEAM OR HOSPITAL STAFF 17 QUESTIONS YOU MIGHT ASK YOURSELF 19 FOR GENERAL INFORMATION ABOUT CLINICAL TRIALS 20 FOR INFORMATION ABOUT SPECIFIC CLINICAL TRIALS
6 6 ENTERING A CLINICAL TRIAL What Is a Clinical Trial? A CLINICAL TRIAL IS A RESEARCH STUDY that is done to answer important questions about medical care. If you choose to take part, you and the study team will work together to find out if a new method of cancer treatment, diagnosis, or prevention is effective. In a clinical trial, researchers don t know if the new method will be better than standard therapy for patients who are being treated now. What researchers do know is that clinical trials will result in better treatments for patients in the future. Although there are many types of clinical trials, this program and booklet focus on trials that test new cancer drugs. Taking part in a clinical trial is voluntary. Anyone can decide not to participate. If you decide to take part in a trial and then change your mind, you can also drop out of the trial at any time. Whatever decision you make, your doctors and nurses will make sure you get the best care possible for your disease.
7 IS IT RIGHT FOR YOU? 7 What Are the Phases of Clinical Trials? Phase I: How much of the new treatment can be given with reasonable safety? The goal of a Phase I study is to find out three things: how much of a new drug can be given safely how often the drug needs to be given what the side effects of the new drug are Generally, if you are one of the first patients to take part in a Phase I study, you will be given a small amount of the drug. This amount is based on animal testing or the safe dose of a similar medication given to other people. In some cases, it is based on the safe dose of the new drug given to people who took part in earlier studies of the drug. If there are no serious side effects, people who enroll later in the same study will receive more of the drug, until the study team learns the maximum amount of the drug that can be given and still be reasonably safe. About 20 to 30 people are included in Phase I studies. The studies are most often carried out at academic medical centers or large hospitals.
8 8 ENTERING A CLINICAL TRIAL Important things to know about Phase I trials: Because you might be one of the first people in the world to receive the new drug, the side effects may not be known. Although this drug has shown promise in the laboratory or in animals, we don t know if it will work against your cancer. Phase II: Does the new treatment work for a specific type of cancer? The goals of a Phase II study are to: continue to gather information about the safety of the drug test whether or not the drug works against a specific kind of cancer In Phase II studies, patients with a specific type of cancer are given the highest dose of the new drug that is thought to be reasonably safe. This dose is based on results from Phase I studies. Generally, no more than 100 people are enrolled in Phase II studies. The studies are often carried out at major hospitals or academic medical centers, but they may also be conducted at local community hospitals.
9 IS IT RIGHT FOR YOU? 9 An important thing to know about Phase II trials: When Phase II trials are conducted, researchers do not know whether or not the new drug will be effective against your cancer. Phase III: Is the new treatment better than standard treatment for a specific type of cancer? The goal of a Phase III study is to compare the new treatment to a standard (meaning current, state-ofthe-art) treatment. Patients are assigned at random to a group that receives standard treatment or to a group that receives the new treatment. This means that the patient is assigned to a group by chance, like rolling dice or flipping a coin, and not by his or her doctor. The patient has an equal chance of being assigned to any one of the groups. Sometimes, the patient and the doctor don t even know which group the patient is in. Rarely, there is no effective standard treatment. If this is the case in a Phase III trial, then the new treatment may be compared to a current known treatment, supportive care, or a placebo (an inactive substance).
10 10 ENTERING A CLINICAL TRIAL In Phase III studies, the treatment is given to hundreds or even thousands of people. The studies are carried out at many treatment centers nationwide. Important things to know about Phase III trials: If the study team learns that one of the drugs is not effective or is too toxic, the study might be changed or stopped earlier than planned. At the beginning of the study, doctors don t know if the new treatment is better than the standard treatment. Patients are assigned at random (by chance, like rolling dice or flipping a coin) to a group. Neither the doctor nor the patient is involved in the decision. In some cases, the patient and the doctor don t know which group the patient is in.
11 IS IT RIGHT FOR YOU? 11 How Are Patients Protected While on a Study? ThEre are three systems in place to keep patients as safe as possible while taking part in a study: protocol review, eligibility, and monitoring. Protocol Review When a researcher wants to perform a clinical trial, he or she must prepare a detailed plan. This is called a protocol. The trial cannot be started until a group of people called the Institutional Review Board (IRB) has reviewed the protocol. The IRB must be satisfied that the trial addresses an important scientific question, is well planned, is as safe as possible, and is ethically sound. These groups are made up of physicians, nurses, scientists, pharmacists, and administrators who may work at the facility offering the trial, and at least one person who is not connected with the health care facility. Federal institutions such as the U.S. Food and Drug Administration (FDA) or the National Cancer Institute (NCI) may also review the study. While the study is going on, the IRB receives regular updates to make
12 12 ENTERING A CLINICAL TRIAL sure the study is being carried out as planned and that any safety issues are addressed promptly. Eligibility, or Do You Fit the Group of People to Be Studied? A patient must meet certain requirements to take part in a clinical trial. First, if your risk from being in the trial is greater than any possible benefit, you might not be able to join the study. Second, the people taking part in some trials must be similar to one another so the study team can learn if the new treatment works the same as or better than the standard treatment. Some examples of study criteria are age, disease type, the ability of body organs to work, and the ability of the person to carry out the normal activities of daily living. Safety Monitoring, or How Will Side Effects Be Found Early? Often, the study treatment has not been used in many people. In these cases it may be hard to predict what side effects might occur. During a study, the team will try to identify any potential side effects as quickly as possible. They may do more tests and physical exams than they would if someone were not taking part in a clinical trial. If you develop unexpected health problems, you would be treated promptly and may have to withdraw from the study.
13 IS IT RIGHT FOR YOU? 13 What Might Help You Decide if Entering a Clinical Trial Is Right for You? If you are eligible and are thinking about taking part in a study, it is important that you find out what options are available and that you think about them carefully. Don t make a decision without getting as much information as you reasonably can. Understand your choices. Bring a trusted family member or friend with you when you meet with the study team to discuss options. That person can: ask questions write down the study team s answers discuss the pros and cons of the study with you after the doctor s visit Find out what the study involves and what other options are available to you. Useful resources include: health care professionals, such as the study team, your primary care physician, or a second medical opinion personal contacts, such as family members and friends, other patients, or a support group the hospital s patient and family resource center or library national organizations like the National Cancer Institute (NCI) or the American Cancer Society (ACS)
14 14 ENTERING A CLINICAL TRIAL Meet with a financial counselor at the study site. He or she can contact your insurance company to find out if it will pay for the extra costs of taking part in the trial. Many insurance companies will pay for a lot of clinical trial-related services. Use a professional medical interpreter if English is not your first language. That person will: make sure that the translation is accurate make it possible for family members or friends to act as advisors in the decision-making process know the medical terms so he or she can translate the medical information clearly and accurately If you are feeling pressured by anyone, even a family member, to make a certain decision, you may always discuss your options with someone else. Possible sources of help include: spiritual leaders friends health care team members, such as your physician, nurse, or social worker psychologists and support group members Remember that you don t have to take part in research. You should not take part in the trial unless you feel it is right for you.
15 IS IT RIGHT FOR YOU? 15 Questions You Might Ask the Study Team or Hospital Staff What should I know about the study? Why is the study being done? Have there been other studies that evaluated this drug? If so, what were the results? Is it possible that I will be treated with an inactive substance (placebo) if I participate in the study? What financial issues I should consider? Will my insurance company pay for any extra costs of participating in the trial? If I don t have insurance, can I still be in the study? If I need long-term treatment for a health problem that might have been caused by the new treatment, will my insurance company pay for it? How will my health care study team follow my care? Who are the health care professionals who will take care of me during the study? Will my primary care physician or primary oncologist be involved? If I withdraw from the study or if I change studies, will my health care team change? When the study is over, will the same doctors and nurses take care of me?
16 16 ENTERING A CLINICAL TRIAL How will the study affect my overall health care? How are the study treatments and procedures different than the regular medical care that I might get if I decide not to take part? Will the study require that I be hospitalized? If so, for how long? Can I take my regular medications while I am in the study? If I enroll in the study, will I be able to find out my test results? If someone else in the study has an unexpected and severe health problem, will I be told? If I think the new treatment worked for me, will I be able to get the same treatment after the study ends? Will I need to keep getting tests done after I stop taking the study drug? Where will I be treated if I participate in the study? What happens if I withdraw from the study? If I withdraw, will I continue to be cared for by the same health care team? Can I switch from one trial to another? How do I get a medical interpreter, and how will his or her services be paid for?
17 IS IT RIGHT FOR YOU? 17 Questions You Might Ask Yourself Because each person is unique, what feels right to someone else might not feel right to you. In other words, when it comes to a clinical trial, you should make a decision based on your personal feelings and needs. Below is a list of questions you might want to ask yourself as you think about whether or not to take part in a clinical trial. Am I able to make the extra trips to the doctor or hospital that might be needed for the study? Do I have family or friends who can help me if I experience special problems during the trial, such as nausea, diarrhea, headaches, fever, or tiredness? Do I feel comfortable receiving a treatment whose risks and benefits are somewhat unknown? Would any of the possible side effects from receiving the study drug be unsatisfactory to me? Will I be able to manage if taking part in the trial means I might miss more work? If taking part in the study might cost me more money than standard treatment, would I be able to afford it? If I am very sick and have exhausted all other treatment options, would I rather receive treatment aimed at making me live comfortably and help me stay at home instead of being in a clinical trial that might cause side effects?
18 18 ENTERING A CLINICAL TRIAL Am I satisfied that my decision is right for me, and not a decision that is being made to please someone else? This program and booklet were created to help you understand what clinical trials are and to help you decide whether or not to take part in a study. We hope you will write down any other questions or concerns and take this booklet with you when you discuss treatment options with the study team. This program is not intended to be a substitute for discussions between you and your doctors or other members of your treatment or research team. If you are considering enrollment in a clinical trial, you are advised to get your questions answered by your physician and clinical trial study team before making your decision.
19 IS IT RIGHT FOR YOU? 19 To Learn More For General Information About Clinical Trials National Cancer Institute (NCI) CANCER ( ) TTY: American Cancer Society ACS-2345 ( ) Provides general information about clinical trials and also a national listing of clinical trials. National Coalition for Cancer Survivorship 1010 Wayne Avenue, Fifth Floor Silver Spring, MD NCCS-YES ( )
20 20 ENTERING A CLINICAL TRIAL For Information About Specific Clinical Trials Dana-Farber/Harvard Cancer Center Provides a listing of all clinical trials that are currently being done through Dana-Farber/Harvard Cancer Center, at Dana-Farber Cancer Institute, Brigham and Women s Hospital, Massachusetts General Hospital, and Beth Israel Deaconess Medical Center. U.S. National Library of Medicine s List of Clinical Trials Provides current information about clinical research studies. National Cancer Institute s Clinical Studies Support Center (CSSC) NCI-1937 ( ) Provides general information about clinical trials as well as a listing of clinical trials currently taking place on the campus of the National Institutes of Health in Bethesda, Maryland.
21 IS IT RIGHT FOR YOU? 21 To View This Program Using the Internet Visit us at: To Request a Copy of This Program Mailing Address: Dana-Farber/Harvard Cancer Center Clinical Trials Education Office Dana-Farber Cancer Institute 450 Brookline Ave. Boston, MA Telephone: On the Web:
22 22 ENTERING A CLINICAL TRIAL My Questions
23 Entering a Clinical Trial Is It Right for You? Acknowledgements Producer: Director: Christina M. Parker, MD Dana-Farber Cancer Institute, Inc. David H. Rose Rose Films Inc.
24 This is an honest and open account of clinical trials: why they are done, what people can learn, why patients should think about joining in - the pluses and minuses - the processes. The programme will really be able to help people make the right decision for them. AWARDS Professor Sally Davies Director of Research and Development Department of Health, London Oh, it was great. You think you know everything about the mechanics of these trials and the video showed me a whole different layer. Mary Alice MacKay Clinical trial participant Dana-Farber Cancer Institute This inspiring, upbeat video can truly help educate patients about clinical trials. The real-life patients in this work are proof that informed people [help] to advance medical research and achieve the best possible clinical outcomes and patient satisfaction. George D. Demetri, MD Director, Center for Sarcoma and Bone Oncology Dana-Farber Cancer Institute and Harvard Medical School The distribution of this program has been supported by a generous gift from the Friends of the Dana-Farber Cancer Institute. Patient Family Education Council Dana-Farber Cancer Institute Oct. 18, Dana-Farber Cancer Institute, Inc. All Rights Reserved
Tissue Banking Advancing Cancer Care Acknowledgments Producer Director Writer Photographer Designer Christina M. Parker, MD Dana-Farber Cancer Institute, Inc. David H. Rose POV-Rose Films Lonnie K. Christiansen
CLINICAL TRIALS Clinical Trials: Improving the Care of People Living With Cancer Presented by Mary McCabe, RN, MA Memorial Sloan-Kettering Cancer Center Carolyn Messner, DSW CancerCare Learn about: Stages
National Cancer Institute Taking Part in Cancer Treatment Research Studies U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health Taking Part in Cancer Treatment Research Studies If
Clinical Trials at PMH What You Need To Know UHN Patient Education Improving Health Through Education A Guide for Patients, Their Families and Friends in the PMH Cancer Program This information is to be
For more infomation about Cancer Clinical Trials at Upstate Cancer Center please call Upstate Connect 1.800.464.8668 TAKING PART IN CANCER TREATMENT RESEARCH STUDIES Information provided by: National Cancer
Clinical Trials: Questions and Answers Key Points Clinical trials are research studies that test how well new medical approaches work in people (see Question 1). Every clinical trial has a protocol, which
National Cancer Institute Taking Part in Cancer Treatment Research Studies U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health This booklet is for people with cancer, their family,
UNDERSTANDING LUNG CANCER CLINICAL TRIALS 1-800-298-2436 LungCancerAlliance.org A GUIDE FOR THE PATIENT 1 TABLE OF CONTENTS INTRODUCTION TO CLINICAL TRIALS What Is a Clinical Trial?...4 Types of Clinical
Cancer Clinical Trials: The Basics What Are Cancer Clinical Trials? Research studies involving people Try to answer scientific questions and find better ways to prevent, diagnose, or treat cancer 2 Why
Cancer Clinical Trials & You: Source: National Cancer Institute What Are Cancer Clinical Trials? Research studies involving people Try to answer scientific questions and find better ways to prevent, diagnose,
Understanding series LUNG CANCER CLINICAL TRIALS 1-800-298-2436 LungCancerAlliance.org A guide for the patient TABLE OF CONTENTS The Basics What is a Clinical Trial?...3 Types of Clinical Trials... 3 Phases
Clinical Trials: What You Need to Know Clinical trials are studies in which people volunteer to test new drugs or devices. Doctors use clinical trials to learn whether a new treatment works and is safe
PARTICIPATING IN CLINICAL TRIALS A GUIDE FOR PEOPLE WITH MS If you have ever taken a medication or received rehabilitative physical therapy, then you have experienced the benefits of clinical research.
CENTERS FOR MEDICARE & MEDICAID SERVICES Medicare & Clinical Research Studies You may have the choice to join a clinical research study to diagnose or treat an illness. If you join a covered clinical research
Ask Us About Clinical Trials Clinical Trials and You. Our specialists and researchers are at the forefront of their fields and are leading the way in developing new therapies and procedures for diagnosing
A Participant s Guide to Mental Health Clinical Research Contents Purpose of this document... 1 What is clinical research?... 2 Why do people choose to participate in research?... 3 What are the different
Clinical Trials Clinical Trials This brochure is for people making decisions about cancer treatment. You may be thinking about a clinical trial for you or your child but need to know more before you decide.
Participating in Alzheimer s Disease Clinical Trials and Studies FACT SHEET When Margaret was diagnosed with earlystage Alzheimer s disease at age 68, she wanted to do everything possible to combat the
North Central Cancer Treatment Group Working with Mayo Clinic to Bring the Latest Cancer Treatment to the Community NCCTG Dedicated to you More than 1.3 million people in the United States will be diagnosed
Clinical Trials: What You Need to Know The Basics of Clinical Trials Clinical trials are studies in which people volunteer to test new drugs or devices. Doctors use clinical trials to learn whether a new
A Treatment Op on for Me? What are Clinical Trials? Clinical research allows scien sts to find new, improved treatments and cures. Medicines used now to treat cancer were studied and tested before pa ents
A Guide to Participating in Clinical Trials Iowa Cancer Resources This guide is intended to help Iowans find resources to participate in clinical trials. The guide is meant to accompany the National Cancer
volunteering for a clinical trial www.centerwatch.com :: about this pamphlet This pamphlet provides an overview of the clinical trials process and answers frequently asked questions that many potential
1 A guide to prostate cancer clinical trials In this fact sheet: What is a clinical trial? Why are trials done? What are trials looking into at the moment? How are clinical trials done? Should I take part
What is a clinical trial? An introduction for patients and families Introduction Life expectancy in Europe in the first decade of this century has continued to rise. We owe this fortunate development to
Medicals c i e n t i f i c study design risks medical-ethics review board 2 Table of contents M e d i c a l - s c i e n t i f i c study Preface 2 Introduction 4 Medical-scientific study 5 Why participate?
National Drug Abuse Treatment Clinical Trials Network STOP SMOKING STUDY Should I Join? NATIONAL INSTITUTES OF HEALTH U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES Introduction Many people who abuse drugs
Frequently Asked Questions (FAQs) Research Rationale 1. What does PrEP stand for? There is scientific evidence that antiretroviral (anti-hiv) medications may be able to play an important role in reducing
Understanding Clinical Trials The UK Clinical Research Collaboration (UKCRC) is a partnership of organisations working to establish the UK as a world leader in clinical research, by harnessing the power
WHI - Volume 1, Section 2 - Consent Form for the Calcium/Vitamin D Part of the WHI Clinical Trial Page 1 CONSENT FORM FOR THE CALCIUM/VITAMIN D PART OF THE WOMEN'S HEALTH INITIATIVE (WHI) CLINICAL TRIAL
Clinical Trials Clinical Trials This brochure is for people making decisions about cancer treatment. You may be thinking about a clinical trial for you or your child but need to know more before you decide.
Research DRUG APPROVAL PROCESS FOR THE TREATMENT OF ALZHEIMER S DISEASE There are certain principles that should be followed when involving people with Alzheimer s disease in research. For more information,
National Cancer Institute U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES National Institutes of Health How You Can Help Medical Research Donating Your Blood, Tissue, and Other Samples You have the choice
Palliative Care The Relief You Need When You re Experiencing the Symptoms of Serious Illness Dealing with the symptoms of any painful or serious illness is difficult. However, special care is available
Phasel clinical trials: what are they all about? Information for people wanting to know more about early clinical trials in cancer, Belfast City Hospital NORTHERN IRELAND CANCER TRIALS CENTRE Introduction
Clinical Trials More answers to beat cancer. Cancer Care Well Respected. Well Connected ṢM Clinical research means more options and new hope. Ingalls Cancer Care connects patients to more options. Ingalls
Palliative Care for Children Support for the Whole Family When Your Child Is Living with a Serious Illness Palliative care provides comfort and support to your child and family. When a child is seriously
Block 1 Introduction Instructions You recently called the National Cancer Institute's Cancer Information Service (CIS) and talked about clinical trials with a Cancer Information Specialist. Please respond
Josephine Silvestre, RN, MSN The University of Chicago Medical Center October 13, 2007 A study in which people participate as volunteers. A clinical trial is conducted to develop potential new treatments
A Checklist for Patients with Breast Cancer Questions to Ask the Doctor 1 and Quick Help Resources 1 Adapted from: American Cancer Society. Detailed Guide: Breast Cancer - What Should You Ask Your Doctor
Volunteer for a CliniCal ReseaRCh study OffICE Of CLINICaL TRIaLS oct.med.nyu.edu email@example.com 212-263-4210 Why NYU Langone Medical Center? NYU Langone Medical Center (NYULMC) is one of the
Track 3: Goals of therapy I was just diagnosed, so my doctor and I are deciding on treatment. My doctor said there are several factors she ll use to decide what s best for me. Let s talk about making treatment
Patient Handbook on Stem Cell Therapies Appendix I of the Guidelines for the Clinical Translation of Stem Cells www.isscr.org 2008, International Society for Stem Cell Research 2 Introduction We have all
+ IF AT FIRST YOU DON T SUCCEED: TRIAL, TRIAL AGAIN Rena Buckstein MD FRCPC Head Hematology Site Group Sunnybrook Odette Cancer Center (OCC) Head of Hematology Clinical Trials Group at OCC + Outline Start
August Is Palliative Care and Cancer Pain Awareness Month What Is Palliative Care? Palliative care is a growing research area that focuses on improving the quality of life of all people living with cancer,
Mesothelioma CLINICAL TRIALS Information for Patients and Families identifying and evaluating experimental treatments table of contents Pg. 2... Phases of a Clinical Trial Pg. 3... Mesothelioma and Clinical
A Greater Understanding A Practical Guide to Clinical Trials Solving Insurance and Healthcare AccessProblems I since 1996 A Greater Understanding Patient Advocate Foundation MISSION STATEMENT Patient Advocate
CLINICAL CASE STUDY SERIES Research on Research: Learning about Phase 1 Trials Phases of clinical trial investigation are described in some detail in the Code of Federal Regulations. Phase 1 is described
March 1, 2013 Marilyn Tavenner, RN, BSN, MHA Acting Administrator Centers for Medicare & Medicaid Services Department of Health and Human Services 200 Independence Avenue, SW Washington, D.C. 20201 Submitted
CANCER FACTS N a t i o n a l C a n c e r I n s t i t u t e N a t i o n a l I n s t i t u t e s o f H e a l t h D e p a r t m e n t o f H e a l t h a n d H u m a n S e r v i c e s The NCI/VA Agreement on
Cancer and Advance Care Planning You ve been diagnosed with cancer. Now what? You have a lot to think about and it can be difficult to know where to start. One important thing you should think about is
A Guide to Clinical Trials For young people with cancer and their parents Children s Cancer and Leukaemia Group www.cclg.org.uk Original booklet produced in conjunction with the CCLG Patient Advocacy Committee.
Cancer Clinical Trials: In-Depth Information The Drug Development and Approval Process 1. Early research and preclinical testing 2. IND application filed with FDA 3. Clinical trials (phases 1, 2, and 3)
DENTAL ASSISTANT get on the dental careers path 36 Is this the job for me? Take this quick quiz to find out if dental assistant is a good direction for you: Are you interested in helping people get and
Clinical Trials Helpful information and answers for patients I joined a clinical trial because I want to make it a better world for my daughter and grandchildren. Hopefully, by the time they re old enough
Glossary of Clinical Trial Terms ADVERSE REACTION: (Adverse Event): Also known as side effects, adverse reactions include any undesired actions or effects of the experimental drug or treatment. Experimental
CLINICAL TRIALS SHOULD YOU PARTICIPATE? by Gwen L. Nichols, MD Gwen L. Nichols, M.D., is currently the Oncology Site Head of the Roche Translational Clinical Research Center at Hoffman- LaRoche. In this
Summary Medical Insurance for Retirees: Basics You Need to Know Last update: June 3, 2014 For most of us, medical insurance is important because it guards us against catastrophic financial losses if we
Advancing research: a physician s guide to clinical trials Recruiting and retaining trial participants is one of the greatest obstacles to developing the next generation of Alzheimer s treatments Alzheimer
Talking About Living Kidney Donation with Family and Friends Purpose of this guide Y ou may be a person who has kidney disease. Perhaps you know someone with kidney disease. Talking about kidney disease
Teaming Up Against Sarcoma Recorded on: April 4, 2013 Darin Davidson, MD, MHSc, FRCSC Assistant Professor, Department of Orthopaedics and Sports Medicine University of Washington School of Medicine Robin
Treatment Helpline 0800 074 8383 prostatecanceruk.org 1 A guide to prostate cancer clinical trials In this fact sheet: What is a clinical trial? Why are trials done? Who works on trials? What are the different
Palliative Care The Relief You Need When You re Experiencing the Symptoms of Serious Illness Healthcare & Rehab Centre Palliative Care Improving quality of life when you re seriously ill Dealing with the
PALLIATIVE CARE SERVICES AND RESOURCES A guide for patients and their loved ones Living well with serious illness A patient and family centered approach to living with serious illness Palliative care addresses
Where World-Class Expertise and Genuine Compassion Come Together 0011000110100111100110111100000101010011000101100010111000010010000100010000100001011110101010101111000 000010111000101110011000110100111100110111100000101010011000101100010111000010010000100010000100
How We Make Sure You Get the Best Health Care Table of Contents Quality Improvement... 1 Care Management... 2 Utilization Management: Working to Get You Covered and Necessary Care... 3 Behavioral Health...
University of California, Los Angeles CONSENT TO PARTICIPATE IN RESEARCH A phase II trial on rizatriptan for Vestibular Migraine Robert W. Baloh, M.D. from the Department of Neurology at the University
Palliative Medicine, Pain Management, and Hospice Devon Neale, MD Assistant Professor Dept of Internal Medicine UNM School of Medicine Pall-i- What??? Objectives: Provide information about Palliative Medicine
Your Pharmacy Benefit: Make it Work for You! www.yourpharmacybenefit.org Table of Contents Choose Your Plan.............................................2 Steps in Choosing Your Pharmacy Benefits.........................
CONSENT TO PARTICIPATE IN A CLINICAL RESEARCH STUDY Adult Patient or Parent, for Minor Patient INSTITUTE: National Cancer Institute PRINCIPAL INVESTIGATOR: Raffit Hassan, M.D. STUDY TITLE: Tissue Procurement
Allsup Medicare Advisor Seniors Survey Examining Medicare Plan Selection Issues Among Seniors November 2009 Confidence in Medicare Plan Only one-quarter of respondents are very confident in their Medicare
Produced November 2010 Next revision due November 2012 How do I find the best place to get treatment for my lymphoma? Introduction Fortunately this is not a question that patients with cancers of the blood
PSYCHOTHERAPY: HOW TO GET STARTED I didn t want to talk about my problems with someone I didn t know. Then I learned how common it is to initially feel hesitant and to even try several therapists before
LUNG CANCER TREATMENTS What you need to know about... clinical trials patient-assisted research studies foreword About LUNGevity LUNGevity is the largest national lung cancer-focused nonprofit, changing
California s Cancer Clinical Trial Law: A clinical trial is a study of a treatment or treatments to find out how well they work in certain patients. Introduction If you are a cancer patient, you and your