Docent Doktor H. NADIR ÇIRAY, PhD Histolog ve Embriyolog. 2000, Kadir Has Universitesi Tip Fakultesi, Histoloji ve Embriyoloji Bolumu (kurucu)

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1 Docent Doktor H. NADIR ÇIRAY, PhD Histolog ve Embriyolog Egitim ve Akademik Dereceler Docent 2004 Yardimci Docent 2000, Kadir Has Universitesi, Istanbul Bolum Baskani 2000, Kadir Has Universitesi Tip Fakultesi, Histoloji ve Embriyoloji Bolumu (kurucu) Gozlemci arastirmaci 2000 (3 ay), Samuel Lunenfeld Arastirma Enstitusu, Toronto, Kanada (Destek Isvec Ulusal Arastirma Fonundan karsilanmistir) Doktora Tez basligi: Yoneten: 1996, Uppsala Universitesi Tip Fakultesi, Uppsala, Isvec Gap junctions in human myometrium; structural and functional aspects (Acta Universitatis Upsaliensis ISBN-10: ) Prof. Dr. Ulf Ulmsten Histoloji ve Embriyoloji Uzmani Tez basligi: Yoneten: 1990, Ankara Universitesi Tip Fakultesi Ultrastructure of human myometrium during pregnancy and labor Prof. Dr. Meral Tekelioglu Tip Doktoru 1987, Ankara Universitesi Tip Fakultesi

2 Mesleki Sertifikalar Senyor Embriyolog, ESHRE, Mesleki Gecmis (Tibbi) Embriyoloji Laboratuarlari Direktoru (Aralik 1999-Mayis 2012) Bahceci Saglik Grubu IVF Laboratuarlari 2011 embriyo transferi siklus sayisi: 7418 taze, 1850 cozdurme Toplam calisan embriyoloji laboratuari/klinigi=6 Klinik Embriyolog ( ) International Hospital Istanbul Embriyolog ( ) Uppsala Universitesi, Uppsala, Isvec Mesleki Gecmis (Idari ve Isletme) Bilimsel Direktor ve Hissedar ( ) Gonagen Sirketi Bahceci Grubunun tibbi malzeme destekcisi. Temsilcisi oldugu IVF ile ilgili urunleri Bahceci Grubunun bulundugu ulkelerde dagitir. Exclusive distributorlukler arasinda Irvine Scientific, UniSense vb. sayilabilir. Sorumluluklar; IVF ile iliskili yeni urunlerin saptanmasi, firmalarla temas kurulmasi, distributorluk olanaklarinin tespiti ve saglanmasi, firmadaki pazarlama elemanlarinin egitimi Bahceci Fulya Klinigi Isletme Muduru ( ) Grubun Fulya da bulunan ana merkezinin isletmesi Sorumluluklar; Personelin idaresi (yaklasik 50 kisi), klinigin gunluk rutininin idamesi, yasal raporlama prosedurleri

3 BIBLIOGRAFI Hakemli Uluslararasi Bilimsel Dergiler 1. Ciray HN, Aksoy T, Goktas C, Ozturk B, Bahceci M. Time-lapse evaluation of human embryo development in single versus sequential culture media-a sibling oocyte study. Journal of Assisted Reproduction and Genetics Jun 20. [Epub ahead of print] 2. Mesut N, Ciray HN, Mesut A, Aksoy T, Bahceci M. Cryopreservation of blastocysts is the most feasible strategy in good responder patients. Fertility and Sterility. 2011;96: Bakircioglu ME, Ulug U, Erden HF, Tosun S, Bayram A, Ciray N, Bahceci M. Klinefelter syndrome: does it confer a bad prognosis in treatment of nonobstructive azoospermia? Fertility and Sterility. 2011;95: Uyar A, Bener A, Ciray HN, Bahceci M. Physician experience in performing embryo transfers may affect outcome. Fertility Sterility. 2011; 95: Coban O, Hacifazlioglu O, Ciray HN, Ulug U, Tekin HI, Bahceci M. Birth after 12 hours of oocyte refrigeration. Fertility Sterility. 2010; 94:2769, e Sismanoglu A, Tekin HI, Erden HF, Ciray NH, Ulug U, Bahceci M. Ovulation triggering with GnRH agonist vs. hcg in the same egg donor population undergoing donor oocyte cycles with GnRH antagonist: a prospective randomized cross-over trial. Journal of Assisted Reproduction and Genetics. 2009; 26: Uyar A, Bener A, Ciray H, Bahceci M. A frequency based encoding technique for transformation of categorical variables in mixed IVF dataset. Conference Proceedings IEEE Engineering Medicine Biology Society. 2009; 1: Bahçeci M, Ulug U, Erden HF, Tosun S, Ciray N. Frozen-thawed cleavage-stage embryo transfer cycles after previous GnRH agonist or antagonist stimulation. Reproductive Biomedicine Online. 2009; 18: Çıray HN, Aksoy T, Yaramanci K, Karayaka I, Bahçeci M. In vitro culture under physiological oxygen concentration improves blastocyst yield and quality: a prospective randomized survey on sibling oocytes. Fertility Sterility. 2009; 91 (4suppl): Çıray HN, Coban O, Bayram A, Kizilkanat A, Bahceci M. Preliminary study of embryo development following assessment of male and female gametes. Reproductive Biomedicine Online. 2008; 16:

4 11. Bakırcıoğlu ME, Erden HF, Çıray HN, Bayazit N, Bahçeci M. Gonadotropin therapy in combination with ICSI in men with hypogonadotrophic hypogonadism. Reproductive Biomedicine Online. 2007; 15: Çıray HN. Even early cleavage and day 2 embryo score. Reproductive Biomedicine Online. 2007; 14(5):666; author reply Çıray HN, Tosun S, Hacifazlioglu O, Mesut A, Bahçeci M. Prolonged duration of transfer does not affect outcome in cycles with good embryo quality. Fertility and Sterility. 2007; 87: Bakırcıoğlu ME, Erden HF, Kaplancan T, Çıray HN, Bener F, Bahçeci M. Aging may adversely affect testicular sperm recovery in patients with Klinefelter s syndrome. Urology. 2006; 68: Çıray HN, Uluğ U, Tosun S, Erden HF, Bahçeci M. Outcome of 1114 ICSI-ET cycles of women 40 years of age and over. Reproductive BioMedicine Online. 2006; 13: Bahçeci M, Uluğ U, Çıray HN, Akman MA, Erden HF. The efficiency of changing embryo transfer time from day 3 to day 2 among women with poor ovarian response: a prospective randomized trial. Fertility and Sterility. 2006; 86: Çıray HN, Karagenç L, Uluğ U, Bener F, Bahçeci M. Early cleavage morphology affects quality and implantation potential of day 3 embryos. Fertility and Sterility. 2006; 85: Ciray HN, L Karagenc, F Bener, U Uluǧ, M Bahçeci. Reply: Interpretations of multinucleation is it ever normal? Fertility and Sterility. 2005;86: Çıray HN, Karagenç L, Uluğ U, Bener F, Bahçeci M. Early cleavage and day 2 mononucleation are correlated to yield embryos with high implantation potential in intracytoplasmic injection cycles. Fertility and Sterility. 2005; 84: Bahçeci M, Çıray HN, Karagenç L, Uluğ U, Bener F. Effect of oxygen concentration during the incubation of embryos of women undergoing ICSI and embryo transfer: a prospective randomized study. Reproductive BioMedicine Online. 2005; 11: Çıray HN, Bener F, Karagenç L, Uluğ U, Bahçeci M. Impact of assisted hatching on ART outcome in women with endometriosis. Human Reproduction. 2005; 20: Uluğ U, Bener F, Karagenç L, Çıray HN, Bahçeci M. Outcomes in couples undergoing ICSI: comparison between fresh and frozen-thawed surgically retrieved spermatozoa. International Journal of Andrology. 2005; 28:

5 23. Ulug U, Ciray NH, Tuzlali P, Bahceci M. Partial hydatidiform mole following the transfer of single frozen-thawed embryo subsequent to ICSI. Reproductive Biomedicine Online. 2004; 9: Karagenc L, Sertkaya Z, Ciray N, Ulug U, Bahceci M. Impact of oxygen concentration on embryonic development of mouse zygotes. Reproductive Biomedicine Online. 2004; 9: Ciray HN, Ulug U, Bahceci M. Transfer of early-cleaved embryos increases implantation rate in patients undergoing ovarian stimulation and ICSI-embryo transfer. Reproductive Biomedicine Online. 2004; 8: Ciray HN, Fu X, Olovsson M, Ahlsen G, Shuman C, Lindblom B, Ulmsten U. Presence and localization of connexins 43 and 26 in cell cultures derived from myometrial tissues from nonpregnant and pregnant women and from leiomyomas. American Journal of Obstetrics and Gynecology. 2000; 182: Fu X, Liu YJ, Ciray N, Olovsson M, Ulmsten U, Gylfe E. Oxytocin-induced oscillations of cytoplasmic Ca2+ in human myometrial cells. Acta Obstetricia et Gynecologica Scandinavica. 2000; 79: Ciray HN, Backstrom T, Ulmsten U. Ineffectiveness of oxytocin on intercellular communication between term pregnant human myometrial cells before labor. American Journal of Obstetrics and Gynecology. 1998; 178: Ciray HN, Backstrom T, Ulmsten U, Roomans GM. Steroid hormone effects on intercellular communication between term pregnant human myometrial cells before labor. Biology of Reproduction. 1996; 55: Ciray HN, Guner H, Hakansson H, Tekelioglu M, Roomans GM, Ulmsten U. Morphometric analysis of gap junctions in nonpregnant and term pregnant human myometrium. Acta Obstetricia et Gynecologica Scandinavica. 1995; 74: Ciray HN, Persson BE, Roomans GM, Ulmsten U. Dye-coupling between term pregnant human myometrial cells before labor:carboxyfluorescein versus lucifer yellow. Cell Biology International. 1995; 19: Ciray HN, Persson BE, Backstrom T, Roomans GM, Ulmsten U. Direct intracellular injections for studying human myometrial gap junctions prior to labor. Acta Obstetricia et Gynecologica Scandinavica. 1994; 73: Roomans GM, Kilarski WM, Ciray N, Persson BE, Backstrom T, Ulmsten U. Structural and functional studies of gap junctions in human myometrium. European Journal of Morphology. 1993; 31:

6 Abstraktlar 1. H.N. Ciray, T. Aksoy, C. Goktas, B. Ozturk, M. Bahceci. Time-lapse evaluation of human embryo development in single versus sequential culture media in a sibling oocyte study. Human Reproduction 27 (Supp1): i105, M. Serdarogullari, H.N. Ciray, S. Yayla, A. Bayram, M. Bahceci. Female offsprings have an advanced mitotic cell cycle starting from the initial cleavage. Human Reproduction 27 (Supp1): i42, A. Bayram, H.N. Ciray, O. Sahin, O. Okutman-Emonts, M. Bahceci. Comparison of morphokinetic parameters between euploid and aneuploid embryos by time-lapse monitoring. Human Reproduction 27 (Supp1): i104, N Mesut, H.N. Ciray, A. Mesut, A. Isler, M. Bahceci. Thaw-transfers of blastocysts cryopreserved between days five to seven: a comparison of clinical outcomes. Human Reproduction 27 (Supp1): i174, O Okutman-Emonts, M Gultomruk, T Aksoy, C Goktas, HN Ciray, M Bahceci. Combination of biopsy and cryopreservation on cleavage-stage human embryos. Reproductive BioMedicine Online 24, S47, Swain JE, Angle M, Ciray N, Liebermann J, Pool T. A commercially available dualbuffered IVF handling medium containing HEPES and MOPS maintains stable ph and supports human sperm survival, normal fertilization following ICSI and embryo development. 16th World Congress on In Vitro Fertilization, Tokyo, Japan, A Bayram, U Ulug, E Bakircioglu, N Ciray, O Sahin, M Bahceci. Comparison of pregnancy and implantation rates of frozen-thawed embryos fertilized with fresh or frozen-thawed testicular sperm and fresh ejaculated sperm of normospermic and oligospermic patients. Fertility and Sterility 96 (3), S208-S208, A Uyar, A Bener, HN Ciray, M Bahceci. Bayesian Networks for Predicting IVF Blastocyst Development. International Conference on Pattern Recognition, , A Uyar, A Bener, HN Ciray, M Bahceci. Prediction of IVF blastocyst development using Bayesian networks, 7th Turkish Medical Informatics Conference, (TURKMIA 2010), October 2010, Cyprus. (Best paper award) 10. O Okutman-Emonts, HN Ciray, M Bahçe, T Aksoy, M Bahceci. Aggressive ovarian stimulation may affect IVF outcome after PGD for reciprocal translocation carriers. Reproductive BioMedicine Online 20; S30, 2010.

7 11. A Uyar, A Bener, HN Ciray, M Bahceci. ROC Based Evaluation and Comparison of Classifiers for IVF Implantation Prediction Electronic healthcare: second international ICST conference, ehealth, A Uyar, A Bener, HN Ciray, M Bahceci. Handling the Imbalance Problem of IVF Implantation Prediction. IAENG International Journal of Computer Science 37, , A Uyar, A Bener, HN Ciray, M Bahceci. A frequency based encoding technique for transformation of categorical variables in mixed IVF dataset. Engineering in Medicine and Biology Society. EMBC A Uyar, A Bener, HN Ciray, M Bahçeci. Adjusting decision threshold in Naive Bayes based IVF embryo selection. Biomedical Engineering Meeting, A Uyar, A Bener, HN Ciray, M Bahceci. Predicting Implantation Outcome from Imbalanced IVF Dataset. Proceedings of the World Congress on Engineering and Computer Science, San Fransisco, 2009 (Best Paper Award). 16. A Uyar, HN Ciray, A Bener, M Bahceci. 3P: Personalized pregnancy prediction in IVF treatment process. Electronic Healthcare, 58-65, U Ulug, NH Ciray, HF Erden, SB Tosun, M Bahceci. Outcome of ICSI cycles with single oocyte retrieval. Does ovarian stimulation with gonadotropins have any impact? Fertility and Sterility 90; S262-S262, ME Bakircioglu, T Kaplancan, H Erden, U Ulug, N Ciray, M Bahceci. The combination of gonadotrophin therapy and intracytoplasmic sperm injection in the treatment of male hypogonadotrophic hypogonadism. Fertility and Sterility 90, S312-S312, ME Bakircioglu, T Kaplancan, HF Erden, N Ciray, U Ulug, M Bahceci. Comparison of intracytoplasmic sperm injection outcomes in patients with nonobstructive azoospermia, cryptozoospermia and oligozoospermia. Fertility and Sterility 90; S314-S314, ME Bakircioglu, HF Erden, N Bayazit, N Ciray, M Bahceci. Microdissection testicular sperm extraction outcomes in different etiological patterns of nonobstructive azoospermia. Fertility and Sterility 88; S391-S392, U Ulug, N Ciray, S Tosun, M Bahceci. The impact of testicular spermatozoa for ICSI on the outcome of cryopresrved-thawed embryo transfers. Fertility and Sterility 86; S161- S161, ME Bakircioglu, H Erden, MA Akman, N Bayazıt, N Ciray, M Bahceci. Comparison of Intracytoplasmic Sperm Injection Outcomes in Patients With Cryptozoospermia and Severe Oligozoospermia. Fertility and Sterility 84; S221-S221, 2005.

8 23. MA Akman, HF Erden, N Ciray, M Bahceci. A Cocktail of GnRH Agonist and Urinary hcg to Trigger LH Surge in GnRH Antagonist-IVF Cycles Yields Higher Pregnancy Rates. Fertility and Sterility 84; S162-S162, HF Erden, MA Akman, N Ciray, M Bahceci. The Results of the Fresh and Frozen Thaw Embryo Transfer Cycles of PCOS Patients in Which GnRH Antagonists Were Used Together With GnRH Agonists for LH Surge. Fertility and Sterility 84; S164-S164, T Camlibel, AK Kolankaya, B Sarikamis, M Karacan, E Enginsu, N Ciray. Coasting: A Safe Way to Prevent Hyperstimulation in IVF and ICSI Cycles. Fertility and Sterility 70, Kitap ve Kitap Bolumleri Çıray HN (2011) Yardimla Ureme Teknikleri: embriyologun gozuyle, Ureme Endokronoljisinde Teknikler ve Cerrahi Tedaviler. Gulekli B (ed.) ISBN Çıray HN (2007) Embriyo secim kriterleri; IVF Laboratuar Teknikleri; Guncel uygulamalar ve yaklasimlar. Delilbasi L (ed.) ISBN Çıray HN (2003) IVF Laboratuarinda Pratik Yaklasimlar. ISBN Davetli Uluslararasi Kurs Konusmasi 2012 ESHRE Pre-Congress Embryology Course Sunum Basligi: Development of Culture Media-Impact on Embryo Viability Uluslararasi Firmalard Bilimsel Danismanlik Irvine Scientific, Santa Ana, CA-2010/2011

9 Uluslararasi Editorluk ve Bilimsel Hakemlik Gorevleri Editorial Board Journal of Clinical Embryology, Bilimsel Hakemlik Journal of Clinical Embryology, Journal of Assisted Reproduction and Genetics, Human Reproduction, (best reviewer 2011) Fertility and Sterility, Reproductive BioMedicine Online, Reproductive Biology and Endocrinology, Mesleki Uyelikler ESHRE (active)- European Society of Human Reproduction and Embryology Turkish Clinical Embryology Society (founder) ALPHA- Society of Scientists in Reproductive Medicine SSR- Society for the Study of Reproduction Egitim Tecrubeleri Kadir Has Universitesi Tip Fakultesi Histoloji ve Embriyoloji Bolumu ( ) Ankara Universitesi Tip Fakultesi Histoloji ve Embriyoloji Bolumu ( ) Doktora Yoneticiligi Asli Uyar, Bogazici Universitesi Bilgisayar Muhendisligi Bolumu -Application of Machine Learning Methods to Prediction of IVF Outcome Arastirma Fonlari TUBITAK 1501 Endustri Destek Programi (2010) Proje Numarasi- Whole Genome Amplification from a single cell and scanning of chromosomal aneuploidies with array TUBITAK 1507 Orta Olcekli Endustri Destek Programi (2011) Proje Numarasi- Assessment and Quantification of oocyte competence concomitant to ICSI

10 Kisisel Dogum Londra, Ingiltere, 1963 Evli ve bir cocuklu

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