OPEN SOURCE AND BOTTOM-UP VRE APPROACH IN WESTERN FRANCE
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1 OPEN SOURCE AND BOTTOM-UP VRE APPROACH IN WESTERN FRANCE Towards supporting accessible, reproducible, and transparent research in the life sciences Yvan Le Bras Cyril Monjeaud Olivier Collin, the GenOuest team & others CNRS UMR 6074 IRISA-INRIA
2 CONTEXT Data, a lot of data, data analysis and communication
3 Datanami Now : Genomics : Next Generation Sequencing Now : Proteomics Next : Bio-imaging Kahn. On the future of genomic data. Science (2011) vol. 331 (6018) pp Digital data Huge amount Heterogenous Critical situation for laboratories
4 Datanami Now : Genomics : Next Generation Sequencing Now : Proteomics Next : Bio-imaging Kahn. On the future of genomic data. Science (2011) vol. 331 (6018) pp Digital data Huge amount Heterogenous Critical situation for laboratories
5 Datanami Now : Genomics : Next Generation Sequencing Now : Proteomics Next : Bio-imaging Kahn. On the future of genomic data. Science (2011) vol. 331 (6018) pp Digital data Huge amount Heterogenous Critical situation for laboratories
6 Loss of analysis skills people with the skills to analyse data are scarce & will become scarcer Ludwig Siegele Welcome to the yotta world The economist, 2012 Facilitate data analysis Skills transfer by Training Accessibility : More usable tools Reproducibility : Peer review / re-analysis / Portability Transparency : Public funding / citizens & society
7 Loss of communication «comprehensible to everyone» Exchange from one domain to another From ICT / IT to scientific domains Between scientific domains e-science
8 E-science Using Full ICT power in Research Infrastructure related
9 E-science Using Full ICT power in Research Infrastructure related But not only! Human resource Tools to use infrastructure
10 E-science Using Full ICT power in Research Infrastructure related But not only! Human resource Tools to use infrastructure From Top-down based on big infrastructure to bottom-up approach with almost no infrastructure: e-biogenouest project
11 E-BIOGENOUEST An innovative VRE: A system of open source systems
12 E-Biogenouest Started in May 2012 for 3 years Funded by Brittany and Pays de la Loire E-science initiative for the Biogenouest network Test an e-science approach Roadmap preparation
13 E-Biogenouest Started in May 2012 for 3 years Funded by Brittany and Pays de la Loire E-science initiative for the Biogenouest network Test an e-science approach More than 150 scientists trained! 1669 meetings ;) Roadmap preparation -UEB C@mpus -CPER -FRM -INCa -H2020 Health Agro Environment 7 articles IT More than 200 users! An innovative VRE concept -Mission interdisciplinarité CNRS -PIA -IFB -Fce Génomique -Rapsodyn -Sciences citoyennes
14 VIRTUAL RESEARCH ENVIRONMENT A system of systems approach based on -Research Lifecycle -Open source solutions
15 VRE: a tool for e-science application Virtual Research Environment Data User Web portal Collaboration softwares Community Processing resources
16 An innovative VRE approach Research Lifecycle Open source solutions Don t reinvente the wheel
17 An innovative VRE approach Research Lifecycle Open source solutions Don t reinvente the wheel
18 An innovative VRE approach Stay here! Research Lifecycle Open source solutions Don t reinvente the wheel
19 Continuum HubZero Galaxy EMME Community Continuum data management & analysis Collaborative environment Collaboration
20 IFB (French Institut of Bioinformatics) & VRE new VRE national working group H2020 Excelerate project facilitate the integration of Europe s bioinformatics resources
21 DATA MANAGEMENT Experimental Metadata Management Environment
22 ISAtools : Experimental data management EMME ISAtools suite to store data & metadata Fonctionalities -based on biomed ontologies -bridge between existing biomed standards -format publication submission -Pydio to upload data -biological investigation repository (data + metadata) Oxford eresearch Centre P. Rocca-Serra et al. Bioinformatics, 26;254(6), 2010
23 ISAtools : Experimental data management EMME ISAtools suite to store data & metadata Fonctionalities -based on biomed ontologies -bridge between existing biomed standards -format publication submission -Pydio to upload data -biological investigation repository (data + metadata) Oxford eresearch Centre P. Rocca-Serra et al. Bioinformatics, 26;254(6), 2010
24 Pydio : File sharing platform Pydio by GenOuest To store & share data as links Informations -Galaxy workspace -EMME workspace Share - data via URI - control - safety - privacy Abstrium SAS Charles du jeu, David Gillard et al.
25 DATA ANALYSIS Analyze, share and visualize data, create workflows through the web
26 What users want DATA ANALYSIS Analyze, share and visualize data, create workflows through the web
27 What users want DATA ANALYSIS Analyze, share and visualize data, create workflows through the web
28 What users have DATA ANALYSIS Analyze, share and visualize data, create workflows through the web
29 Galaxy : Data analysis web platform GALAXY by GenOuest To analyse & share data as processes and tools Informations jobs 152 users More than 800 tools Share - data - histories - workflows - tools Penn state university J. Goecks, A. Nekrutenko, J. Taylor, et al. Genome Biol, 25;11(8):R86, 2010
30 Galaxy : Data analysis web platform GALAXY by GenOuest To analyse & share data as processes and tools Informations jobs 152 users More than 800 tools Share - data - histories - workflows - tools Penn state university J. Goecks, A. Nekrutenko, J. Taylor, et al. Genome Biol, 25;11(8):R86, 2010
31 Galaxy : GUGGO Working group Galaxy User Group Grand Ouest 5 western France computing centers - Plouzané : Ifremer CAPArmor - Roscoff : IFB-GO ABiMS - Rennes : IFB-GO GenOuest + INRA BIPAA - Nantes : IFB-GO BIRD - Angers : Bioinformatics IRHS team Actions - meetings (tools dev / admin / users) - A dedicated Tool Shed - Training (Galaxy Training Network) - A group on ebgo HUB
32 Giving the key Genocloud Do what you want
33 HUBZERO Collaboration platform dedicated to scientifics collaboration
34 HUBzero : Scientifique collaborative platform ebgo HUB HUBzero to share knowledge and manage groups and projects Informations 218 users 127 projects 57 groups 796 resources > 400 unique users by month Purdue University M. McLennan, R. Kennell. Comput Sci Eng, 12:48-53, 2010.
35 HUBzero : Scientifique collaborative platform VRE in production : Welcome to CeSGO HUB!
36 What are our goals? For society Open Science and open data For end users scientists communities Data management plan Preserve, access, share & visualise (data & analytics processes) Help for project management For ICT Facilitate the use of tools Research Service Accelerate switch between dev to production state Optimise infrastructures use (storage, computing & network ) Infrastructure for data infastructure of data
37 What are our goals? For society Open Science and open data For end users scientists communities Data management plan Preserve, access, share & visualise (data & analytics processes) Help for project management For ICT Facilitate the use of tools Research Service Accelerate switch between dev to production state Optimise infrastructures use (storage, computing & network ) Infrastructure for data infastructure of data
38 From Biologist to Biologist! Not ITist Don t cross lines you don t want to cross Keep your time to do science, not remember how you can copy a directory
39 VRE AS A STARTING BLOCK Horizon & Challenge
40 CeSGO : Western France e-science metadata Data management URI Life sciences protocols
41 CeSGO : Western France e-science cloud Reproducibility Galaxy versioning docker
42 CeSGO : Western France e-science wiki Accessibility Analytics processes Public resources Experiments Publications
43 CeSGO : Western France e-science New VREs! Connected using semantic web approaches Thanks to DOI attribution Linked Data
44 CeSGO : Western France e-science New methods to make science! Scitizen A web platform + a smartphone app Create your dedicated citizen science project web page MMOS A new method for citizen science A first Biogenouest call in december 2014
45 A JOINT VENTURE
46 Thanks Galaxy team Thanks ISA team
47 Thanks HUBzero team Michael McLennan Betsy Hillery Nicholas J Kisseberth Shawn Rice Nikki Huang Claire Stirm Shirley Skeel Shirley Skeel
48 Thanks for your attention GenOuest Bio-informatics core facility Symbiose group IRISA/INRIA GenOuest-Dyliss-Genscale ebgo HUB (collaboration) Scitizen portal (citizen science) EMME portal (data management) Galaxy instance (data analysis) GO4Bioinformatics (education )
49 Thanks for your attention GenOuest Bio-informatics core facility Symbiose group IRISA/INRIA GenOuest-Dyliss-Genscale ebgo HUB (collaboration) Scitizen portal (citizen science) EMME portal (data management) Galaxy instance (data analysis) GO4Bioinformatics (education )
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