SCIENTIFIC PROGRAMME

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1 SCIENTIFIC PROGRAMME FRIDAY, Sept 14 th, 2012 THURSDAY, Sept 13 th, 2012 WEDNESDAY, Sept 12 th, 2012 TUESDAY, Sept 11 th, 2012 TUESDAY, SEPT 11 TH, 2012 Congress Hall 13:00 Meeting of the Executive Boards of the Polish Biochemical Society 17:00 Opening Ceremony Congress Hall 18:00 PaL Parnas Award Lecture Marcin Jaciuk, Elżbieta Nowak, Krzysztof Skowronek, Anna Tańska, Marcin Nowotny International Institute of Molecular and Cell Biology, Warsaw, Poland Structural studies of bacterial nucleotide excision repair pathway 18:30 OL Opening Lecture Anita Magowska Poznan University of Medical Sciences, Poznań, Poland The Polish-German neighborhood in life sciences 19:00 Welcome cocktail 16

2 SCIENTIFIC PROGRAMME WEDNESDAY, SEPT 12 TH, 2012 Congress Hall 09:00 09:45 FL Volker A. Erdmann (Free University, Berlin, Germany) The discovery of Spiegelzymes and their potentials in molecular biology and medicine SESSION 1 Mechanisms of Ageing Room A Prof. Ewa Sikora (Nencki Institute of Experimental Biology, Warsaw,, Prof. Krzysztof Książek (Poznan University of Medical Sciences, Poznań,, Prof. Alexander Bürkle (University of Konstantz, Konstantz Germany) 10:00 10:30 L1.1 Alexander Bürkle (University of Konstantz, Konstantz Germany) Towards biomarkers of human ageing the ongoing EU FP7 project MARK-AGE 10:30 11:00 L1.2 Grzegorz Bartosz (Lodz University, Łódź, Poland/ University of Rzeszów, Rzeszów, Yeasts as model organisms in the studies of ageing 11:00 11:20 O1.1 Grażyna Mosieniak (Nencki Institute of Experimental Biology PAS, Warsaw, Stress-induced premature senescence and autophagy in human cancer cells 11:40 12:10 L1.3 Andrzej Składanowski (Gdansk University of Technology, Gdańsk, Spontaneous and drug-induced premature senescence of tumor cells and its role in tumor drug resistance to anticancer treatment 12:10 12:40 L1.4 Jacek Witkowski (Medical University of Gdansk, Gdańsk, Immune cell ageing in chronic diseases cause or consequence? TUESDAY, Sept 11 th, 2012 WEDNESDAY, Sept 12 th, 2012 THURSDAY, Sept 13 th, 2012 FRIDAY, Sept 14 th,

3 FRIDAY, Sept 14 th, 2012 THURSDAY, Sept 13 th, 2012 WEDNESDAY, Sept 12 th, 2012 TUESDAY, Sept 11 th, :40 12:50 O1.2 Agnieszka Daca (Medical University of Gdansk, Gdańsk, The influence of CMV infection on the immunological parameters in healthy elderly people 12:50 13:00 O1.3 Jerzy Foerster (Medical University of Gdansk, Gdańsk, Influence of chronic CMV infection on the selected parameters of lipid and carbohydrate metabolism in young and elderly healthy subjects LUNCH 14:30 15:00 L1.5 Ewa Sikora (Nencki Institute of Experimental Biology PAS, Warsaw, The role of cellular senescence in ageing and age-related diseases 15:00 15:30 L1.6 Heinz D. Osiewacz (Goethe University, Frankfurt, Germany) Unravelling a network of pathways involved in mitochondrial quality and lifespan control 15:30 15:50 O1.4 Anna Bielak-Żmijewska (Nencki Institute of Experimental Biology PAS, Warsaw, Replicative and premature senescence of vascular smooth muscle cells 16:10 16:30 O1.5 Halina Waś (Nencki Institute of Experimental Biology PAS, Warsaw, Dark side of senescence non-proliferative cancer cells that exhibit proinflammatory and proangiogenic phenotype 16:30 17:00 L1.7 Krzysztof Książek (Poznan University of Medical Sciences, Poznań, Biochemical Trojan horse, or how the high glucose may accelerate cellular senescence SESSION 3 Gene Expression Regulations: Epigenetics, and Alternative Splicing Room B Prof. Volker A. Erdmann (Free University of Berlin, Berlin, Germany), Prof. Marta Koblowska (Institute of Biochemistry and Biophysics PAS, Warsaw,, Prof. Jan Barciszewski (Institute of Bioorganic Chemistry PAS, Poznań, 10:00 10:30 L3.1 Jörn Walter (University of Saarbrücken, Saarbrücken, Germany) Epigenomics the road to functional genomics 18

4 10:30 11:00 L3.2 Andrzej Jerzmanowski (University of Warsaw and Institute of Biochemistry and Biophysics, PAS, Warsaw, Global and specific roles of linker histones in chromatin 11:00 11:20 O3.1 Albrecht Bindereif (University of Giessen, Giessen, Germany) Regulation of alterantive mrna splicing: factors, mechanisms, networks 11:40 12:10 L3.3 Artur Jarmołowski (Adam Mickiewicz University, Poznań, Posttranscriptional regulation of microrna expression in plants 12:10 12:40 L3.4 Albert Jeltsch (University of Stuttgart, Stuttgart, Germany) Reading and writing of methylation marks 12:40 13:00 O3.2 Jarosław Paluszczak (Poznan University of Medical Sciences, Poznań, DNA methylation markers in cancer diagnostics LUNCH 14:30 15:00 L3.5 Reinhard Lührmann (Max Plank Institute, Goettingen, Germany) Assembly, structural dynamics and function of the spliceosome 15:00 15:30 L3.6 Jolanta Zakrzewska-Czerwińska (University of Wroclaw, Wrocław, To Replicate or Not To Replicate? Regulation of the initiation step of bacterial chromosome replication 15:30 15:50 O3.3 Gunter Meister (University of Regensburg, Regensburg, Germany) Regulation of small RNA-guided gene silencing 16:10 16:40 Szymon Świeżewski (Institute of Biochemistry and Biophysics PAS, Warsaw, ncrna in Arabidopsis development 16:40 17:00 O3.4 Tomasz Wilanowski (Nencki Institute of Experimental Biology PAS, Warsaw, The grainyhead-like 3 and mir-21 in skin cancer 17: L3.7 Janusz M. Bujnicki (international Institute of Molecular and Cell Biology Warsaw, Poland; Adam Mickiewicz University, Poznań, If there is an order in all of this disorder... Structural bioinformatics of the human spliceosomal proteome TUESDAY, Sept 11 th, 2012 WEDNESDAY, Sept 12 th, 2012 THURSDAY, Sept 13 th, 2012 FRIDAY, Sept 14 th,

5 FRIDAY, Sept 14 th, 2012 THURSDAY, Sept 13 th, 2012 WEDNESDAY, Sept 12 th, 2012 TUESDAY, Sept 11 th, :30 17:45 O3.5 Marta M. Gabryelska (Institute of Biorganic Chemistry PAS, Poznań, Prediction of hammerhead ribozyme intracellular activity with the catalytic coe parameters fingerprint 17:45 18:00 O3.6 Magdalena Skonieczna (Silesian University of Technology, Gliwice, The role of free radicals in mirna regulation of gene expression in K562 cancer cells SESSION 4 Cell Signaling Room C Prof. Marta Miączyńska (International Institute of Molecular and Cell Biology, Warsaw,, Prof. Hanna Kmita (Adam Mickiewicz University, Poznań,, Prof. Alfred Wittinghofer (Max Planck Institute, Dortmund, Germany) L4.1 Czeslaw Cierniewski (Institute of Medical Biology PAS and Medical University of Lodz, Łódź, Integrin receptor signaling and matrix metalloproteinases regulation L4.2 Theresia Stradal (University of Münster, Germany) Signalling to actin assembly in cell motility and host pathogen interaction L4.3 Alfred Wittinghofer (Max Planck Institute, Dortmund, Germany) Ras membrane localization: old problems, new avenues Ulrich Benjamin Kaupp (Center of Advanced European Studies and Research, Bonn, Germany) The non-genomic action of progesterone in human sperm an ionotropic rather than metabotropic mechanism Klaus Gerwert (University of Bochum, Bochum, Germany) Catalysis of small GTPases by GAPs L4.4 Jens-Ole Bock (Sigma-Aldrich, Copenhagen, Denmark) Advanced gene targeting in eukaryotic cells and animals using the zinc finger nuclease technology LUNCH 20

6 L4.5 Johannes Bluijssen (Adam Mickiewicz University, Poznań, STAT1 and IRF-mediated signal integration between IFNγ and TLR activating pathways in vascular disease L4.6 Bozena Kaminska (Nencki Institute of Experimental Biology PAS, Warsaw, Tumor-derived small integrin ligands polarize host immune response and impact tumor progression O4.1 Monika Kusio-Kobiałka (Nencki Institute of Experimental Biology PAS, Warsaw, PERK-eIF2α signaling pathway activated by BCR-ABL promotes resistance to imatinib and shows cancerogenic potential in vitro and in vivo Frauke Melchior (University of Heidelberg, Heidelberg, Germany) Wrestling with SUMO O4.2 Monika Hartmann (Leibniz Institute for Age Research, Fritz Lipmann Institute, Jena, Germany) Regulation of membrane protein cleavage O4.3 Paweł Niewiadomski (Stanford University School of Medicine, Stanford, CA, USA) From the cell s antenna into the nucleus regulation of Gli protein activation at the primary cilium SESSION 7 Protein Transport and Assembly (sponsored by EMBO) Room D Prof. Agnieszka Chacińska (International Institute of Cell and Molecular Biology, Warsaw,, Prof. Dr. Peter Rehling (GBM Study Group Molecular Cell Biology, University of Göttingen, Germany) 10:00 10:30 David Ron (University of Cambridge, Cambridge, UK) Cellular adaptation to unfolded protein load in the endoplasmic reticulum 10:30 11:00 L7.1 Manajit Hayer-Hartl (Max Planck Institute of Biochemistry, Martinsried, Germany) Chaperones for folding, assembly and maintenance of Rubisco TUESDAY, Sept 11 th, 2012 WEDNESDAY, Sept 12 th, 2012 THURSDAY, Sept 13 th, 2012 FRIDAY, Sept 14 th,

7 FRIDAY, Sept 14 th, 2012 THURSDAY, Sept 13 th, 2012 WEDNESDAY, Sept 12 th, 2012 TUESDAY, Sept 11 th, :00 11:20 O7.1 Justyna Kusek (Centre for Physiology and Pharmacology, Medical University of Vienna, Vienna, Austria) Pharmacochaperonning of the ER-retained A1-adenosine receptor 11:40 12:10 L7.2 Krzysztof Liberek (University of Gdańsk, Chaperone proteins in control of protein aggregation and disaggregation 12:10 12:40 L7.3 Mikael Simons EMBO Young Investigator Lecture (University of Göttingen/Max-Planck-Institute for Experimental Medicine, Göttingen, Germany) Cell polarity in myelinating glia: From membrane flow to diffusion barrier 12:40 13:00 O7.2 Piotr Bragoszewski (International Institute of Molecular and Cell Biology, Warsaw, Competition between proteasomal degradation and protein import in the biogenesis of mitochondrial intermembrane space proteins SESSION 9 Metabolic disease Room D Prof. Grzegorz Węgrzyn (Gdansk University, Gdańsk, Poland, Prof. Arndt Rolfs (University of Rostock, Rostock, Germany) 14:30 15:00 Peter Bauer (University of Tübingen, Tübingen, Germany) Biochemical and genetic basis of Niemann-Pick type C 15:00 15:30 L9.1 Maciej Adamowicz (The Children s Memorial Health Institute, Warsaw, Congenital disorders of glycosylation (CDG) 16:10 16:40 O9.1 Katarzyna Mamica (Jagiellonian University, Cracow, The comparison of direct LDL cholesterol measurement and calculated LDL cholesterol level in relation to matrix effects 16:40 17:00 O9.2 Aleksandra Miszkiel (Gdansk University of Technology, Gdańsk, Activity regulation of GlcN-6-P synthase as an alternative way for diabetes treatment 22

8 SCIENTIFIC PROGRAMME SESSION 2 THURSDAY, SEPT 13 TH, 2012 Genomics, Proteomics, Metabolomics Medical and Environmental Implications Room A Prof. Maciej Stobiecki (Institute of Bioorganic Chemistry PAS, Poznań,, René P. Zahedi (Leibniz Institute of Analytical Sciences ISAS, Dortmund, Germany), Prof. Marek Figlerowicz (Institute of Bioorganic Chemistry PAS, Poznań, 10:00 10:30 L2.1 Ryszard Adamiak (Institute of Bioorganic Chemistry PAS, Poznań, RNAComposer: automated high-resolution structure prediction for large RNAs 10:30 11:00 L2.2 Stanisław Cebrat (University of Wroclaw, Wrocław, Prediction of functional structure of eukaryotic chromosomes by computer modeling 11:00 11:20 L2.3 Maciej Wiznerowicz (Wielkopolska Center of Oncology, Medical University Poznań, The Cancer Genome Atlas Project: Current Status and Future Applications 11:40 12:10 L2.4 Paweł Bednarek (Institute of Bioorganic Chemistry PAS, Poznań, Combining genomic and metabolomic analysis to elucidate plant immunity related metabolic pathways 12:10 12:40 L2.5 Oliver Kayser (Technical University of Dortmund, Dortmund, Germany) Time dependent metabolomics and transcriptional analysis of cannabinoid biosynthesis in Cannabis sativa var. Bedrobinol and Bediol grown under standardized condition and with genetic homogeneity 12:40 13:00 O2.1 Agnieszka Żmieńko (Institute of Bioorganic Chemistry PAS, Poznań, Functional genomics approach to unveil new gene players in plant response to salinit LUNCH TUESDAY, Sept 11 th, 2012 WEDNESDAY, Sept 12 th, 2012 THURSDAY, Sept 13 th, 2012 FRIDAY, Sept 14 th,

9 FRIDAY, Sept 14 th, 2012 THURSDAY, Sept 13 th, 2012 WEDNESDAY, Sept 12 th, 2012 TUESDAY, Sept 11 th, :30 15:00 L2.6 Michał Dadlez (Institute of Biochemistry and Biophysics PAS, Warsaw, RAGE receptor dimeric structure studied by hydrogen-deuterium exchange monitored by mass spectrometry 15:00 15:30 L2.7 Piotr Widłak (Oncology Center, Gliwice, Mass spectrometry-based profiling of serum proteome detection of changes related to progression of cancer and response to anticancer treatment 15:30 16:00 L2.9 Andrej Shevchenko (Max Planck Institute, Dresden, Germany) Full lipidome snapshot and its interpretation 16:20 16:40 O2.2 Magdalena Łuczak (Institute of Bioorganic Chemistry PAS, Poznań, Analysis of the plasma proteome in chronic kidney disease in the context of progressive cardiovascular disease 16:40 17:00 O2.3 Clare Sansom (University of London, London, UK) Modelling the risk of inhibitor formation in haemophilia A 17:00 17:20 O2.4 Łukasz Marczak (Institute of Bioorganic Chemistry PAS, Poznań, Mass spectrometric-analysis of nonenzymatic posttranslational protein modification 17:20 17:40 O2.5 Emilia Bonar (Jagiellonian University, Krakow, A proteomic view of Staphylococcus aureus host-specific virulence factors 17:40 18:00 O2.6 Robert Nawrot (Adam Mickiewicz University, Poznań, Proteomic analysis of Chelidonium majus plants grown in different stress conditions 18:00 18:30 L2.8 Rene Zahedi (Leibniz Institute of Analytical Sciences ISAS, Dortmund, Germany) The first comprehensive and quantitative analysis of human platelet protein composition allows the comparative analysis of structural and functional pathways 24

10 SESSION 5 Molecular Mechanisms of Motility Room C Prof. Przemysław Wojtaszek (Adam Mickiewicz University, Poznań,, Prof. Ingo Morano (Max-Delbrück-Center for Molecular Medicine, Berlin, Germany) 10:00 10:30 L5.1 Ingo Morano (Max-Delbrück-Center for Molecular Medicine, Berlin, Germany) Functional roles of essential light chains of myosin II 10:30 11:00 L5.2 Peter Nick (Karlsruhe Institute of Technology, Karlsruhe, Germany) Why plants need wrong-way kinesins 11:00 11:20 O5.1 Magdalena Sobczak (Nencki Institute of Experimental Biology, PAS, Warsaw, DOCK7, a Rho-family GEF, is a novel myosin VI binding partner in neurosecretory PC12 cells 11:40 12:10 L5.3 Halina Gabryś (Jagiellonian University, Cracow, Actin alone or with myosin? The mechanism of chloroplast movement 12:10 12:40 L5.4 Walter Steffen (Hannover Medical School, Hannover, Germany) Cytoplasmic dynein, a molecular motor with properties of a universal motor 12:40 12:50 O5.2 Aleksandra Simiczyjew (University of Wroclaw, Wroclaw, The role of adhesive podosome-like structures in migration of colon cancer cells with different modes of motility 12:50 13:00 O5.3 Ewa Szczesna (Nencki Institute of Experimental BiologyPAS, Warsaw, Mechanism of movement generation by kinesin-14 Ncd TUESDAY, Sept 11 th, 2012 WEDNESDAY, Sept 12 th, 2012 THURSDAY, Sept 13 th, 2012 FRIDAY, Sept 14 th,

11 SESSION 6 New Vistas in Plant Molecular Biology Room D FRIDAY, Sept 14 th, 2012 THURSDAY, Sept 13 th, 2012 WEDNESDAY, Sept 12 th, 2012 TUESDAY, Sept 11 th, 2012 Prof. Andrzej Kononowicz (University of Lodz, Łódź,, Prof. Andrzej Guranowski (University of Life Sciences, Poznań,, Prof. Enrico Schleiff (Goethe University, Frankfurt am Main, Germany) 14:30 15:00 L6.1 Justin Lee (IPB, Halle, Germany) Signal transduction in plant immunity response 15:00 15:30 L6.3 Seith J Davis (Max-Planck Institute, Köln, Germany) TIME FOR COFFEE mediates between the circadian clock and JA signalling by repressing MYC2 protein accumulation 15:30 16:00 L6.2 Michał Sikorski (Institute of Bioorganic Chemistry, PAS, Poznań, Phytohormone-binding proteins in legume plants 16:20 16:40 O6.1 Rafał Archacki (Institute of Biochemistry and Biophysics, PAS, Warsaw, Chromatin mechanisms and hormone signaling in plants 16:40 17:00 O6.2 Przemysław Nuc (Max-Planck-Institute of Molecular Plant Physiology, Potsdam, Germany and Institute of Molecular Biology and Biotechnology, Adam Mickiewicz University, Poznań, Small RNAs in plant nutrient signaling and homeostasis 17:00 17:20 O6.3 Izabela Sierocka (Adam Mickiewicz University, Poznań, Regulation of gene expression during the sexual reproduction in liverworts the oldest living land plants 17:20 17:40 O6.4 Adriana Szmidt-Jaworska (Nicolaus Copernicus University, Toruń, Cyclic nucleotide signal transduction in plants 17:40 18:00 O6.5 Marcin Pieczynski (Adam Mickiewicz University, Poznań, Down-regulation of CBP80 gene expression as a strategy to engineer drought-tolerant potato 26

12 SESSION 8 Biochemical and molecular targets of chemoprevention Room B Prof. Wanda Baer-Dubowska (Poznan University of Medical Sciences, Poznań,, Dr Agnieszka Bartoszek (Gdansk University of Technology, Gdańsk,, Prof. Claus Jacob (Saarland State University, Saarbruecken, Germany) 10:00 10:30 L8.1 Claus Jacob (Saarland State University, Saarbruecken, Germany) The cellular thiolstat as target for chemopreventive and redox modulating agents 10:30 11:00 L8.2 Jędrzej Antosiewicz (Gdańsk University of Medical Sciences, Gdańsk, Anticancer organosulfur compounds from garlic induces oxidative stress in prostate cancer cells by activating JNK-p665hc -Itch signaling pathway 11:00 11:15 O8.1 Aleksandra Wiczk (University of Gdansk, Gdańsk, Inhibition of Survivin synthesis in prostate cancer cells a novel mechanism of anticancer activity of sulforaphane, a cruciferous vegetable-derived isothiocyanate 11:40 12:10 L8.3 Elke Richling (University of Technology Kaiserslautern, Kaiserslautern, Germany) Chemopreventive constituents vs. genotoxic contaminants in food the example of coffee 12:10 12:40 L8.4 Hausruedi Glatt (German Institute of Human Nutrition, Potsdam-Rehbruecke, Germany) Genotoxicity, the dark site of glucosinolates: 1-methoxy-3- indolylmethyl glucosinolate is a potent mutagen in vitro and forms high levels of DNA, RNA and protein adducts in animal models and humans 12:40 13:00 O8.2 Marek Murias (Poznan University of Medical Sciences, Poznań, Piceatannol, living in the shadow of famous brother LUNCH 14:30 15:00 L8.5 Ryszard Oliński (Nicolaus Copernicus University, Collegium Medicum, Bydgoszcz, 8-oxoguanine and 5-hydroxymethylcytosine as a new epigenetic marks; is there any place for chemoprevention to change the pattern? TUESDAY, Sept 11 th, 2012 WEDNESDAY, Sept 12 th, 2012 THURSDAY, Sept 13 th, 2012 FRIDAY, Sept 14 th,

13 FRIDAY, Sept 14 th, 2012 THURSDAY, Sept 13 th, 2012 WEDNESDAY, Sept 12 th, 2012 TUESDAY, Sept 11 th, :00 15:30 L8.6 Adriana Albini (IRCCS MultiMedica, Milan, Italy) The tumor microenvironment as target for cancer therapy and prevention 15:30 16:00 L8.7 Jan Lubiński (Pomeranian Medical University, Szczecin, Selenoprotein genotypes as well as selenium levels in organisms are critical features of human cancer risk 16:20 16:40 O8.3 Agnieszka Bartoszek (Gdansk University of Technology, Gdańsk, Dietary intervention with beetroot juice during doxorubicin cancer chemotherapy in vivo reduces markers of oxidative stress 16:40 17:00 O8.4 Barbara Licznerska (Poznan University of Medical Sciences, Poznań, Estrogen metabolism as a target for breast cancer chemoprevention 17:00 17:15 O8.5 Katarzyna Lubecka-Pietruszewska (Lodz Medical University, Łódz, Chemopreventive effects of bioactive plant components on estrogen-receptor-positive and negative breast cancer cells in vitro 17:15 17:30 O8.6 Zofia Suchocka (Medical University of Warsow, Warsaw, Is SELOL triglyceride derivative of Se (IV) a remedium for prostate cancer? 17:30 17:45 O8.7 Khashayar Tabari (Islamic Azad University, Lahijan Lahijan Iran) Decontamination of Aflatoxin M1 by lactobacilli and bidobacteria: An experimental case study 17:45 18:00 O8.8 Paulina Koczurkiewicz (Jagiellonian University, Cracow, Effect of triterpene saponosides and clinically applied in cancer therapy drug-mitoxantrone on human cancer and normal cells 28

14 SESSION 9 Metabolic disease Room D 10:00 10:30 L9.2 Hieronim Jakubowski (Institute of Bioorganic Chemistry PAS, Poznań, Mechanisms underlying pathological manisfestations of genetic hyperhomocysteinemia in cystathionine beta-synthase deficiency 10:30 11:00 Arndt Rolfs (University of Rostock, Rostock, Germany) New biomarkers in lysosomal storage disorders 11:00 11:20 O9.3 Uladzimir Spas (Grodno State Medical University, Grodno, Belarus) Sepsis and marker endothelial damage 11:40 12:10 L9.3 Anna Tylki-Szymańska (The Children s Memorial Health Institute, Warsaw, Twenty years experience with enzyme replacement therapy for metabolic diseases 12:10 12:40 L9.4 Grzegorz Węgrzyn (University of Gdansk, Gdańsk, Substrate reduction therapies for lysosomal storage diseases 12:40 13:00 O9.4 Łukasz Kaczyński (Jagiellonian University, Cracow, A pragmatic methodology as a measure of the effectiveness in metabolic diseases research SESSION 10 Cellular Bioenergetics Room C Prof. Adam Szewczyk (Nencki Institute of Experimental Biology PAS, Warsow,, Prof. Wiesława Jarmuszkiewicz (Adam Mickiewicz University, Poznań, 14:30 15:00 L10.1 Peter Rehling (GBM Study Group Molecular Cell Biology, University of Göttingen, Göttingen, Germany) Biogenesis of mitochondrial membrane protein complexes 15:00 15:20 O10.1 Michał Rurek (Adam Mickiewicz University, Poznań, Mitochondrial biogenesis of plant mitochondria in stressfrom proteomics to physiology 15:20 15:40 O10.2 Michal Laskowski ((Nencki Institute of Experimental Biology PAS, Warsaw, Mitochondrial potassium channels in Dictyostelium discoideum TUESDAY, Sept 11 th, 2012 WEDNESDAY, Sept 12 th, 2012 THURSDAY, Sept 13 th, 2012 FRIDAY, Sept 14 th,

15 FRIDAY, Sept 14 th, 2012 THURSDAY, Sept 13 th, 2012 WEDNESDAY, Sept 12 th, 2012 TUESDAY, Sept 11 th, :40 16:00 O10.3 Natalia Niedźwiecka (University of Gdansk, Gdańsk, Kinetic characteristic of NAD(P)-dependent malic enzyme a key enzyme for herring (Clupea harengus) spermatozoa bioenergetics 16:20 16:40 O10.4 Natalia Grzegorzak (The Medical University of Silesia, Katowice, The effect of the vitamin E on the morphological picture of kidneys and the activity selected enzymes on the rat intoxicated with sodium fluoride 16:40 17:00 O10.5 Małgorzata Czarna (University of Wrocław, Wrocław, Mitochondrial/nuclear responses to the loss of the mitochondrial protease FtsH4 during Arabidopsis seed germination 17:00 17:20 O10.6 Andrzej Woyda-Ploszczyca (Adam Mickiewicz University, Poznan, Mitochondrial uncoupling protein of Acanthamoeba castellanii is activated by lipid peroxidation end product, hydroxynonenal 17:20 17:40 O10.7 Anna Kajma (Nencki Institute of Experimental Biology PAS, Warsaw, Polyunsaturated fatty acids and mitochondrial potassium channels 17:40 18:00 Pre-poster Presentations 18:00 18:15 O10.7 Daniel Soor Measuring the cell function using real-time cellular bioenergetics 30

16 SCIENTIFIC PROGRAMME FRIDAY, SEPT 14 TH, :00 09:45 PL Matthias Sprinzl (Biochemistry Laboratory, University of Bayreuth, Bayreuth, Germany) Perspectives of Nucleic Acid Biosensors for medical applications; Electrically readable biochips for rapid RNA analysis SESSION 2 Genomics, Proteomics, Metabolomics - Medical and Environmental Implications Room A Prof. Maciej Stobiecki (Institute of Bioorganic Chemistry PAS, Poznań,, Prof. Marek Figlerowicz (Institute of Bioorganic Chemistry PAS, Poznań,, René P. Zahedi (Leibniz Institute of Analytical Sciences ISAS, Dortmund, Germany) 10:00 10:30 L2.10 Günter Allmaier (Vienna University of Technology, Vienna, Austria) Venom peptidomics and proteomics-from small molecule candidate drugs to neurotoxic phospholipases 10:30 11:00 L2.11 Zoltán Takáts (University of Giessen, Giessen, Germany) Mass spectrometric profiling of biological tissues a comprehensive tool for histopathology 11:00 11:20 O2.7 Arkadiusz Piotrowski (Medical University of Gdansk, Gdansk, Genomic structural rearrangements in unaffected glandular tissue from breast cancer patients 11:40 12:10 L2.12 Piotr Kachlicki (Institute of Plant Genetics PAS, Poznań, Profiling of phenolic compounds in monocots plants 12:10 12:40 O2.8 Jacek Mokrosiński (University of Copenhagen, Copenhagen, Denmark) From the whole genome sequencing to a single receptor function functional genomics of selected 7-transmembrane receptors potentially involved in pathogenesis of metabolic disorders TUESDAY, Sept 11 th, 2012 WEDNESDAY, Sept 12 th, 2012 THURSDAY, Sept 13 th, 2012 FRIDAY, Sept 14 th,

17 FRIDAY, Sept 14 th, 2012 THURSDAY, Sept 13 th, 2012 WEDNESDAY, Sept 12 th, 2012 TUESDAY, Sept 11 th, :40 13:00 O2.9 Krzysztof Sikorski (Adam Mickiewicz University, Poznań, Identification and verification of diagnostic markers of subclinical atherosclerosis by combined genomic and bioinformatic approaches SESSION 6 New Vistas in Plant Molecular Biology Room D 10:00 10:30 L6.4 Stanisław Karpiński (University of Life Sciences, Warsaw, Are plants intelligent? Exponentially integrated quantum-molecular overall regulation of growth, photosynthesis, defence and acclimatory responses in Arabidopsis 10:30 11:00 L6.5 Anton Schäffner (Helmholtz Zentrum Munich, Germany) Ab initio identification of the substrate of an orphan enzyme via non-targeted metabolomics-the glucosyltransferase UGT76B1 and its substrate isoleucic acid modulate plant defense 11:00 11:20 O6.6 Olga Sztatelman (Jagiellonian University, Cracow, Sumoylation of phototropin2, Arabidopsis blue light receptor 11:40 12:10 L6.6 Enrico Schleiff (Goethe University, Frankfurt am Main, Germany) Crosstalk between the chaperone network and heat stress transcription factors in plants 12:10 12:40 L6.7 Andrzej Guranowski (University of Life Sciences, Poznań, Dinucleoside polyphosphates and some other uncommon nucleotides function as alarmones in plants 12:40 13:00 O6.7 Krzysztof Brzezinski (University of Bialystok, Białystok, High-resolution crystal structures of complexes of plant S-adenosyl-L-homocysteine hydrolase (Lupinus luteus) 32

18 SESSION 8 Biochemical and molecular targets of chemoprevention Room B Prof. Józef Dulak (Jagiellonian University, Cracow,, Prof. Regina Brigelius-Flohe (University of Potsdam, Potsdam, Germany) L8.8 Regina Brigelius-Flohe (University of Potsdam, Potsdam, Germany) Activation of Nrf2 under moderate selenium deficiency L8.9 Agnieszka Łoboda (Jagiellonian University, Cracow, Role of Nrf2 and HO-1 in kidney fibrosis O8.9 Agnieszka Toma (M. Sklodowska-Curie Memorial Cancer Center and Institute of Oncology, Gliwice, Heat Shock Transcription Factor 1 mediates resistance of melanoma cells to doxorubicin by-up-regulation of ABC transporters L8.10 Józef Dulak (Jagiellonian University, Cracow, Novel hallmarks of cancer and targets for chemoprevention: role for micrornas L8.11 Katarzyna Piwocka (Nencki Institute of Experimental Biology, Warsaw, Natural polyphenol curcumin in multi-target treatment of apoptosis-resistant cancers O8.10 Violetta Krajka-Kuźniak (Poznan University of Medical Sciences, Poznan, Betanin induces Nrf2-mediated expression of phase II detoxifying/antioxidant enzymes in human liver cell lines SESSION 11 The Glycolytic Landscape from kinetics to epigenetics Room C Prof. Dariusz Rakus (Wroclaw University, Wroclaw,, Prof. Sybille Mazurek (University of Giessen, Germany) 10:00 10:30 L11.1 Sybille Mazurek (University of Giessen, Germany) Pyruvate kinase M2: A Key regulator of the tumor metabolic phenotype 10:30 11:00 L11.2 Dariusz Rakus (University of Wroclaw, Wrocław, Astrocytic glycolysis regulates activity of neuronal network 11:00 11:20 O11.1 Michał Prendecki (Poznań University of Medical Sciences, Poznań, IDH1 mutation analysis in 165 brain tumors TUESDAY, Sept 11 th, 2012 WEDNESDAY, Sept 12 th, 2012 THURSDAY, Sept 13 th, 2012 FRIDAY, Sept 14 th,

19 FRIDAY, Sept 14 th, 2012 THURSDAY, Sept 13 th, 2012 WEDNESDAY, Sept 12 th, 2012 TUESDAY, Sept 11 th, :40 12:10 L11.3 Jacek Wiśniewski (Max-Planck-Institute of Biochemistry, Martinsried, Germany) Proteomics as a tool to trace qualitative and quantitative changes in glycolysis 12:10 12:40 L11.4 Dominika Malińska (Nencki Institue of Experimental Biology PAS, Warsaw, Disturbances in glycogen structure and metabolism implications for intracellular energy homeostasis 16:00 17:00 Open Society Lecture Krzysztof Książek (Katedra i Zaklad Patofizjologii Uniwersytetu Medycznego im. Karola Marcinkowskiego w Poznaniu) Dlaczego i jak się starzejemy? Czy człowiek może żyć 1000 lat? Collegium Maius, sala. im. Śniadeckich ul. Fredry 10, Poznań 34

20 WORKSHOPS Room Company Presentation Speaker 12 Sept :00 14:30 Part I Seminar Monitor cell viability, cytotoxicity & Filip Napierała caspase-dependent apoptosis A Promega Part II Instrument demonstration Dr. Michaela Mack The Versatility of the GloMax -Multi+ Detection System with Instinct Software B Perkin Elmer JANUS Mini Automated Workstation Stefan Knabel, Mini with Huge Potential: Find out how Maciej Stopa it can help with your cellular applications Part I A new approach for Copy Number Variation detection: The power of the Droplet Digital PCR technology Gautier Grellety C Bio-Rad Polska from Bio-Rad Part II Targeting multiple protein levels at the same time: the Power of Gyula Csanadi Multiplexing D Perlan Technologies Agilent Technologies Andrew Few E Merck Innovative Solutions for Cellular Analysis Dr. Cornelia F B D E F Meranco Perkin Elmer Labart Roche Open Exome (13:00 15:30) Leachables dlaczego warto stosować najlepsze materiały zużywalne 13 Sept :00 14:30 Volocity 3D Image Analysis made easy relate cellular structure to function Perfecting qpcr - Quanta BioSciences/ Labart VWR International Group Part I Roche 454 Sequencing: Today, Tomorrow, and Beyond Part II SeqCap EZ enrichment libraries: advance your genomic research with targeted re-sequencing. Part I Illumina Explore The Broadest Range of Next Generation Sequencing Applications Part II Fluidigm - The Power of Microfluidics The Digital PCR Roessler Dr. Rafał Grzeskowiak (Eppendorf AG) James Hutt, Fabien Bonnaud Dr. Yves Ohandja (Quanta Biosciences Inc.) Bill Cigich, Roche Diagnostics Dr. Markos Mihalatos, Roche Diagnostics 35

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