INCORPORATING 3D PRINTING INTO YOUR BUSINESS MODEL. Dr Phil Reeves, Vice President of Strategic Consulting

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1 INCORPORATING 3D PRINTING INTO YOUR BUSINESS MODEL Dr Phil Reeves, Vice President of Strategic Consulting 1

2 WARNING

3 I AM NOT A BIOTECHNOLOGIST

4 I AM A MANUFACTURING ENGINEER

5 WITH A DIFFERENCE

6 6

7 Who has heard the term 3D Printing before today?

8 3-years of constant media exposure 8

9 So what are 3D Printing technologies? 3D printing processes are automated systems that take 2-dimensional layers of computer data and rebuild them into 3D solid objects 9

10 10

11 Who knew about 3D Printing 3-years ago?

12 Who knew about 3D Printing 5-years ago?

13 Who knew about 3D Printing 10-years ago?

14 Who knew about 3D Printing 20-years ago?

15 Who knew about 3D Printing 30-years ago?

16 30 years ago..

17 3D Printing timeline Chuck Hull files US Patent Layer manufactured tools Open source 3D Printing emerges Stratasys is formed 250,000 machines globally Layer manufactured casting patterns 49,000 machines globally Commercial Rapid Prototyping Layer manufactured production parts

18 30 years of materials development ORGANIC CERAMIC POLYMER METALLIC Waxes Tissue / cells Wood / paper Beta-Tri calcium Phosphate Alumina Mullite ABS Polyamide (nylon) Aluminium Tool Steel Zirconia Silicon Carbide Silica (sand) Plaster Graphite Filled PA PEEK Thermosetting epoxies Ceramic (nano) loaded epoxies PMMA Polycarbonate Polyphenylsulfone Titanium Inconel Cobalt Chrome Copper Stainless steel Gold / platinum Hastelloy ULTEM Aluminium loaded polyamide Silicon Multimaterial multifunctional systems 18

19 30-years of machine diffentiation $200 $35,000 $1,400,000 19

20 3D Printing timeline Chuck Hull files US Patent Layer manufactured tools Open source 3D Printing emerges Stratasys is formed 250,000 machines globally Layer manufactured casting patterns 49,000 machines globally Commercial Rapid Prototyping Layer manufactured production parts

21 INTRODUCING STRATASYS WORLD S LEADING ADDITIVE MANUFACTURING COMPANY FOUNDED IN 1988 BY SCOTT CRUMP PRESIDENT OF STRATASYS INC. HEADQUARTERED IN EDEN PRAIRE, MINNESOTA AND REHOVOT, ISRAEL OVER 30 TECHNOLOGY AND LEADERSHIP AWARDS PUBLICALLY TRADED ON NASDAQ (SSYS) $750M REVENUE (2014) OVER 800 GRANTED OR PENDING ADDITIVE MANUFACTURING PATENTS GLOBALLY 129,197 CUMULATIVE SYSTEMS SOLD AS OF MARCH 31, 2015

22 The 3D printing Solutions company

23 AT STRATASYS STRATEGIC CONSULTING WE EMPOWER & SUPPORT ORGANIZATIONS TO DEVELOP & IMPLIMENT STRATEGIES THAT TRANSFORM THE WAY THEY IMAGINE, DESIGN, MANUFACTURE & DELIVER PRODUCTS USING 3D PRINTING

24 SO WHY ARE COMPANIES TURNING TO 3D PRINTING AS A POTENTIAL WAY OF MAKING PRODUCTS 24

25 Enabling Design Complexity Increased Part Functionality Supply Chain Realignment THE SIX DRIVERS FOR ADDITIVE MANUFACTURING ADOPTION Life Cycle Sustainability Product Personalization Low Volume Production

26 SO HOW DOES THIS MAP TO APPLICATIONS IN THE WIDER BIO-PHARMA & MEDTECH SECTOR? 26

27 Enabling Design Complexity Increased Part Functionality Supply Chain Realignment Life Cycle Sustainability Product Personalization Low Volume Production

28 Filters and strainers 28

29 Heat exchangers 2 29

30 Catalysts 30

31 Lattices 31

32 Lattices used as scaffold and constructs Algae laden scaffold after 1 day of culture Algae laden scaffold after 12 days of culture 32

33 3D bio-printing of tissue for clinical trials 33

34 Lattices used as drug 34

35 Microfluidics and micro reactors 35

36 But 3D Printing is not just for large structures 36

37 37

38 38

39 39

40 40

41 4 41

42 42

43 Sub micron scale structures 43

44 Enabling Design Complexity Increased Part Functionality Supply Chain Realignment Life Cycle Sustainability Product Personalization Low Volume Production

45 hydrophilic + hydrophobic constructs Direction of fluid motion Hydrophobic Hydrophilic 45

46 Conductive and non-conductive materials 46

47 Dual material (seeded) scaffolds Hydrogel matrix Extremely robust and tough hydrogel implants. Composite of two biopolymers. Material can be compressed 99% and stretch 5 times its original size. 500 micron layer thickness 47

48 Dual material cell systems 48

49 Digital drug therapies dosing & reaction 49

50 Enabling Design Complexity Increased Part Functionality Supply Chain Realignment Life Cycle Sustainability Product Personalization Low Volume Production

51 Spare parts 51

52 Spare parts (not just spares) 52

53 3D printed tooling Blow mould Injection mould Embossing & pressing tools 53

54 Development hardware & test rigs 54

55 Distributed manufacture 55

56 Enabling Design Complexity Increased Part Functionality Supply Chain Realignment Life Cycle Sustainability Product Personalization Low Volume Production

57 Patient specific devices 57

58 Surgical planning models 58

59 Enabling Design Complexity Increased Part Functionality Supply Chain Realignment Life Cycle Sustainability Product Personalization Low Volume Production

60 Drug delivery devices 60

61 Device housings 61

62 3D printed tungsten collimators 62

63 Calibration phantoms 63

64 This is all (almost) happening today

65 Where will 3D printing impact on your businesses?

66 QUESTIONS Dr Phil Reeves, VP Strategic Consulting +44 (0)

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