CORK INSTITUTE OF TECHNOLOGY INSTITIÚID TEICNEOLAÍOCHTA CHORCAÍ

Size: px
Start display at page:

Download "CORK INSTITUTE OF TECHNOLOGY INSTITIÚID TEICNEOLAÍOCHTA CHORCAÍ"

Transcription

1 CORK INSTITUTE OF TECHNOLOGY INSTITIÚID TEICNEOLAÍOCHTA CHORCAÍ Module Title: Topics in Organic Chemistry Module Code: CHEO 7003 School : Science Programme Title: Bachelor of Science in Analytical & Pharmaceutical Chemistry Stage 3 BSc. in Analytical Chemistry with Quality Assurance Stage 3 Programme Code: SCHEM_7_Y3 SCQUA_8_Y3 External Examiner(s): Internal Examiner(s): Dr Claire Lennon Dr W O Doherty Instructions: Answer four question in total. Each question carries equal marks Duration: 2 hours Sitting: Christmas 2013 Date: Requirements for this exam: Chemical Shift Tables Note to Candidates: Please check the Programme Title and the Module Title to ensure that you have received the correct examination paper. If in doubt please contact an Invigilator.

2 Q1. (a) Explain what is meant by keto-enol tautomerisation. Give an example of such tautomerism. (b) (i) List the component reactions of the Robinson annulation reaction. [4 marks] (ii) Give the product, A, of the Robinson annulation reaction for the following reagents [8 marks] (iii) The Robinson annulation is often not carried out as a single pot reaction in particular when using the above conditions. One of the products of the component reactions is isolated first. At what stage is this isolation carried out? Why is this done, what complications/side reactions can occur? [8 marks] Q2. (a) Tartaric acid has a structure as given in the following diagram. It has two chiral centres. (i) (ii) How many possible stereoisomers can be drawn for any molecule with two chiral centres? Highlight the chiral centres in tartaric acid with an asterisk* (redraw in your answer book). [4 marks] Draw the 2S,3R and 2R,3S stereoisomers of tartaric acid. In your answer, explain your use of the Cahn-Ingold-Prelog sequence rules. [6 marks]

3 (b) (iii) What is the relationship between the 2S,3R and 2R,3S stereoisomers of tartaric acid. [3 marks] The following product is a result of a mixed aldol condensation reaction. (i) What are the two carbonyl starting materials? [4 marks] (ii) Identify which is the nucleophile and which is the electrophile. [2 marks] (iii) What are the other possible structures that could be formed from the two carbonyl starting materials that you have indicated in part (i). Why can these other products be formed? [6 marks] Q3. (a) Explain what is meant by the term effective magnetic field strength. [4 marks] (b) (i) Explain the origin of splitting in an NMR spectrum. [3 marks] (ii) Construct the splitting pattern you would expect to see for the Ha protons in the following molecule. Assume 3 J ac ~ 3 J ab. [8 marks] (c) Deduce the structure of the compound with molecular formula C 11 H 22 O 2 from the following IR and 1 H NMR data:

4 IR: 1740cm -1 strong 1250cm -1 strong NMR: (ppm) multiplicity peak area Coupling constant(s) (Hz) 0.86 s d t m / t d [10 marks] Q4. (a) Write the mechanism for the solid-state Merrifield peptide synthesis. In answer clearly identify the role of blocking and activating groups. [10 marks] (b) Explain how Edman s Reagent is used to determine the amino acid sequence in a peptide chain. Show a general reaction mechanism detailing the cleavage of the peptide bond. [9 marks] (c) What is the isoelectric point and how is it determined for an amino acid? [6 marks]

5 Q5 (a) The following pyridine can be synthesized using the Hantzsch synthesis method. (b) (i) Detail the starting materials, and reagents required. (ii) This is a multi-step process, which involves an ester enamine as a key intermediate. Draw the mechanism for reaction that produces this ester enamine, using the reagents above. [10 marks] (iii) What is the driving force for the production of the pyridine from the dihydropyridine derivative? To prevent side reactions in a mixed aldol reaction, it is necessary for one of the reagents to be electrophilic only. Give an example of such a reagent and explain why it can only act as an electrophile. Q6 (a) (i) Detail the reagents used in the haloform test and the characteristic product that indicates a positive test result. [3 marks] (ii) Give a structure of an alcohol with the formula C 5 H 11 OH that would give a positive haloform result. (b) Discuss the difference between kinetic and thermodynamic enolate anions and their formation. Give examples of the relevant structures of these enolates anions and reagents that would be used to produce the relevant anions. [9 marks] (c) What is meant by optically active molecules? [3 marks] (d) What is meant by the terms absolute configuration and relative configuration of a molecule

6

A Grignard reagent formed would deprotonate H of the ethyl alcohol OH.

A Grignard reagent formed would deprotonate H of the ethyl alcohol OH. 216 S11-E2 Page 2 Name Key I. (9 points) Answer in the boxes below the following questions for the Grignard reagent C 3 -Mg. (1) (2 points) Is the carbon atom associated with magnesium electrophilic or

More information

NMR and other Instrumental Techniques in Chemistry and the proposed National Curriculum.

NMR and other Instrumental Techniques in Chemistry and the proposed National Curriculum. NMR and other Instrumental Techniques in Chemistry and the proposed National Curriculum. Dr. John Jackowski Chair of Science, Head of Chemistry Scotch College Melbourne john.jackowski@scotch.vic.edu.au

More information

The Four Questions to Ask While Interpreting Spectra. 1. How many different environments are there?

The Four Questions to Ask While Interpreting Spectra. 1. How many different environments are there? 1 H NMR Spectroscopy (#1c) The technique of 1 H NMR spectroscopy is central to organic chemistry and other fields involving analysis of organic chemicals, such as forensics and environmental science. It

More information

Chapter 22 Carbonyl Alpha-Substitution Reactions

Chapter 22 Carbonyl Alpha-Substitution Reactions John E. McMurry www.cengage.com/chemistry/mcmurry Chapter 22 Carbonyl Alpha-Substitution Reactions The α Position The carbon next to the carbonyl group is designated as being in the α position Electrophilic

More information

CHEM 208(Organic Chemistry I) Instructor: Dr. Niranjan Goswami. Tel: (618)545-3361. Email: Ngoswami@kaskaskia.edu. Web: www.kc.cc.il.

CHEM 208(Organic Chemistry I) Instructor: Dr. Niranjan Goswami. Tel: (618)545-3361. Email: Ngoswami@kaskaskia.edu. Web: www.kc.cc.il. CHEM 208(Organic Chemistry I) Instructor: Dr. Niranjan Goswami Tel: (618)545-3361 Email: Ngoswami@kaskaskia.edu Web: www.kc.cc.il.us/ngoswami CHEM 208 COURSE SYLLABUS KASKASKIA COLLEGE NAME TERM YEAR TEXT:

More information

3. Semester Completion date: May 9, 2016. a. You can finish early, and you can start early (or late), but you MUST FINISH BY MAY 9

3. Semester Completion date: May 9, 2016. a. You can finish early, and you can start early (or late), but you MUST FINISH BY MAY 9 4 Dates, Flexible Schedules: Go-At-Your-Own-Pace Asynchronous. 1. FLEXIBILITY. You can schedule your own test dates (so long as you finish all by May 9, 2016) 2. The Official semester start date is January

More information

Combinatorial Chemistry and solid phase synthesis seminar and laboratory course

Combinatorial Chemistry and solid phase synthesis seminar and laboratory course Combinatorial Chemistry and solid phase synthesis seminar and laboratory course Topic 1: Principles of combinatorial chemistry 1. Introduction: Why Combinatorial Chemistry? Until recently, a common drug

More information

2814 hains, Rings and Spectroscopy June 2003 Mark Scheme 2814 Mark Scheme June 2003 The following annotations may be used when marking: X = incorrect response (errors may also be underlined) ^ = omission

More information

Sample exam questions for First exam CHM 2211

Sample exam questions for First exam CHM 2211 Sample exam questions for First exam CM 2211 1. The IR absorption due to the stretching of which of these carbon-hydrogen bonds occurs at the highest frequency? I II III E) V IV V 2. ow many signals would

More information

Isomers Have same molecular formula, but different structures

Isomers Have same molecular formula, but different structures Isomers ave same molecular formula, but different structures Constitutional Isomers Differ in the order of attachment of atoms (different bond connectivity) Stereoisomers Atoms are connected in the same

More information

The Aldol Condensation

The Aldol Condensation The Aldol ondensation Synthesis and Analysis of 2,3,4,5-Tetraphenylcyclopentadienone Yakety Sax Bennie ill theme song TPP eactions of Aldehydes and Ketones ' 1. Nucleophilic Addition. 2. Substitution at

More information

Resonance Structures Arrow Pushing Practice

Resonance Structures Arrow Pushing Practice Resonance Structures Arrow Pushing Practice The following is a collection of ions and neutral molecules for which several resonance structures can be drawn. For the ions, the charges can be delocalized

More information

Organometallics Study Seminar Chapter 13: Metal-Ligand Multiple Bonds

Organometallics Study Seminar Chapter 13: Metal-Ligand Multiple Bonds Organometallics Study Seminar Chapter 13: Metal-Ligand Multiple Bonds Contents 1. Carbene Complexes 2. Silylene Complexes 3. Metal-Heteroatom Multiple Bonds 1. Carbene Complexes 1.1 Classes of Carbene

More information

Organic Chemistry Tenth Edition

Organic Chemistry Tenth Edition Organic Chemistry Tenth Edition T. W. Graham Solomons Craig B. Fryhle Welcome to CHM 22 Organic Chemisty II Chapters 2 (IR), 9, 3-20. Chapter 2 and Chapter 9 Spectroscopy (interaction of molecule with

More information

Peptides: Synthesis and Biological Interest

Peptides: Synthesis and Biological Interest Peptides: Synthesis and Biological Interest Therapeutic Agents Therapeutic peptides approved by the FDA (2009-2011) 3 Proteins Biopolymers of α-amino acids. Amino acids are joined by peptide bond. They

More information

Determination of Equilibrium Constants using NMR Spectrscopy

Determination of Equilibrium Constants using NMR Spectrscopy CHEM 331L Physical Chemistry Laboratory Revision 1.0 Determination of Equilibrium Constants using NMR Spectrscopy In this laboratory exercise we will measure a chemical equilibrium constant using key proton

More information

CNAS ASSESSMENT COMMITTEE CHEMISTRY (CH) DEGREE PROGRAM CURRICULAR MAPPINGS AND COURSE EXPECTED STUDENT LEARNING OUTCOMES (SLOs)

CNAS ASSESSMENT COMMITTEE CHEMISTRY (CH) DEGREE PROGRAM CURRICULAR MAPPINGS AND COURSE EXPECTED STUDENT LEARNING OUTCOMES (SLOs) CNAS ASSESSMENT COMMITTEE CHEMISTRY (CH) DEGREE PROGRAM CURRICULAR MAPPINGS AND COURSE EXPECTED STUDENT LEARNING OUTCOMES (SLOs) DEGREE PROGRAM CURRICULAR MAPPING DEFINED PROGRAM SLOs Course No. 11 12

More information

Suggested solutions for Chapter 3

Suggested solutions for Chapter 3 s for Chapter PRBLEM Assuming that the molecular ion is the base peak (00% abundance) what peaks would appear in the mass spectrum of each of these molecules: (a) C5Br (b) C60 (c) C64Br In cases (a) and

More information

IR Applied to Isomer Analysis

IR Applied to Isomer Analysis DiscovIR-LC TM Application Note 025 April 2008 Deposition and Detection System IR Applied to Isomer Analysis Infrared spectra provide valuable information about local configurations of atoms in molecules.

More information

For example: (Example is from page 50 of the Thinkbook)

For example: (Example is from page 50 of the Thinkbook) SOLVING COMBINED SPECTROSCOPY PROBLEMS: Lecture Supplement: page 50-53 in Thinkbook CFQ s and PP s: page 216 241 in Thinkbook Introduction: The structure of an unknown molecule can be determined using

More information

How to Quickly Solve Spectrometry Problems

How to Quickly Solve Spectrometry Problems How to Quickly Solve Spectrometry Problems You should be looking for: Mass Spectrometry (MS) Chemical Formula DBE Infrared Spectroscopy (IR) Important Functional Groups o Alcohol O-H o Carboxylic Acid

More information

CEM, First in Microwave Peptide Synthesis

CEM, First in Microwave Peptide Synthesis CEM, First in Microwave Peptide Synthesis In 2002, a CEM biochemist named Jonathan Collins presented his concept of a microwave-assisted peptide synthesis system to several colleagues. Collins concept

More information

Organic Spectroscopy

Organic Spectroscopy 1 Organic Spectroscopy Second Year, Michaelmas term, 8 lectures: Dr TDW Claridge & Prof BG Davis Lectures 1 4 highlight the importance of spectroscopic methods in the structural elucidation of organic

More information

Molecule Projections

Molecule Projections Key Definitions ü Stereochemistry refers to the chemistry in 3 dimensions (greek stereos = solid). This science was created by Pasteur (1860), van Hoff et LeBel (1874). ü Stereisomers are isomeric molecules

More information

SOLID SUPPORTS AND CATALYSTS IN ORGANIC SYNTHESIS

SOLID SUPPORTS AND CATALYSTS IN ORGANIC SYNTHESIS SOLID SUPPORTS AND CATALYSTS IN ORGANIC SYNTHESIS Editor Professor K. SMITH, M.SC,PhD. Head of Department of Chemistry University College of Swansea Wales ELLIS HORWOOD PTR PRENTICE HALL NEW YORK LONDON

More information

Assessment Method 1: Oral seminar presentation

Assessment Method 1: Oral seminar presentation 2013-2014 Assessment Report College of Sciences & Mathematics Chemistry & Biochemistry Chemistry, Master's Expected Outcome 1: Effective Oral Communication Skills Students in M.S. degree Program will demonstrate

More information

These instructions are for a classroom activity which supports OCR A Level Chemistry A.

These instructions are for a classroom activity which supports OCR A Level Chemistry A. Lesson Element Keyword activities Instructions for teachers These instructions are for a classroom activity which supports OCR A Level Chemistry A. Just a minute! To run this activity you will need a set

More information

Previous lecture: Today:

Previous lecture: Today: Previous lecture: The energy requiring step from substrate to transition state is an energy barrier called the free energy of activation G Transition state is the unstable (10-13 seconds) highest energy

More information

Syllabus for General Organic Chemistry M07A- Fall 2013 Prof. Robert Keil

Syllabus for General Organic Chemistry M07A- Fall 2013 Prof. Robert Keil Syllabus for General Organic Chemistry M07A- Fall 2013 Prof. Robert Keil Textbook and Materials What you must buy: Organic Chemistry 4 th Ed. Janice G. Smith, McGraw Hill. (Older edition is fine) Chem

More information

California State Polytechnic University, Pomona. Exam Points 1. Nomenclature (1) 30

California State Polytechnic University, Pomona. Exam Points 1. Nomenclature (1) 30 Chem 316 Final Exam Winter, 2008 Beauchamp ame: Topic Total Points Exam Points 1. omenclature (1) 30 Credit 2. Explanation of elative eactivities of Aromatic 20 Compounds or Carbonyl Compounds 3. eactions

More information

Chemistry INDIVIDUAL PROGRAM INFORMATION 2015 2016. 866.Macomb1 (866.622.6621) www.macomb.edu

Chemistry INDIVIDUAL PROGRAM INFORMATION 2015 2016. 866.Macomb1 (866.622.6621) www.macomb.edu Chemistry INDIVIDUAL PROGRAM INFORMATION 2015 2016 866.Macomb1 (866.622.6621) www.macomb.edu Chemistry PROGRAM OPTIONS CREDENTIAL TITLE CREDIT HOURS REQUIRED NOTES Associate of Science Chemistry 64 CONTACT

More information

Quality. Now Certified to ISO 9001:2008

Quality. Now Certified to ISO 9001:2008 Quality Now Certified to ISO 90012008 Quality Policy It is Peptides International's goal is to achieve complete customer satisfaction by addressing customer needs and delivering what we promise. The company

More information

j. SO 3, SO 2, NaCl, Na 2 O (1 mark each) Total 10 a) 525 kj mol -1 per mole of Mg (2 marks) (-1 for incorrect sign or unit)

j. SO 3, SO 2, NaCl, Na 2 O (1 mark each) Total 10 a) 525 kj mol -1 per mole of Mg (2 marks) (-1 for incorrect sign or unit) ANSWERS RUND 1 1. This is a question about trends in chemistry a. Na, S 8, Al, Si b. 2, 4, N 3, Li c. Mg, Na, a, K d. Mg 2+, Na +, F -, l - e. K, Na, l, F f. Si, S, P, l g. Br 2, l 2, 2, N 2 h. XeF 4,

More information

HOMEWORK PROBLEMS: IR SPECTROSCOPY AND 13C NMR. The peak at 1720 indicates a C=O bond (carbonyl). One possibility is acetone:

HOMEWORK PROBLEMS: IR SPECTROSCOPY AND 13C NMR. The peak at 1720 indicates a C=O bond (carbonyl). One possibility is acetone: HMEWRK PRBLEMS: IR SPECTRSCPY AND 13C NMR 1. You find a bottle on the shelf only labeled C 3 H 6. You take an IR spectrum of the compound and find major peaks at 2950, 1720, and 1400 cm -1. Draw a molecule

More information

Table of contents. Bibliografische Informationen http://d-nb.info/1006571213. digitalisiert durch

Table of contents. Bibliografische Informationen http://d-nb.info/1006571213. digitalisiert durch 1. Research scope: The role of structure rigid'tf'ication in nature and chemistry 1 2. Establishing a Dha=Tap backbone scan in order to elucidate structural properties of the N-terminusofNPY 5 2.1 Introduction.

More information

Biochemistry - I. Prof. S. Dasgupta Department of Chemistry Indian Institute of Technology, Kharagpur Lecture-11 Enzyme Mechanisms II

Biochemistry - I. Prof. S. Dasgupta Department of Chemistry Indian Institute of Technology, Kharagpur Lecture-11 Enzyme Mechanisms II Biochemistry - I Prof. S. Dasgupta Department of Chemistry Indian Institute of Technology, Kharagpur Lecture-11 Enzyme Mechanisms II In the last class we studied the enzyme mechanisms of ribonuclease A

More information

EXPERIMENT 5: DIPEPTIDE RESEARCH PROJECT

EXPERIMENT 5: DIPEPTIDE RESEARCH PROJECT EXPERIMENT 5: DIPEPTIDE RESEARCH PROJECT Pre-Lab Questions: None. 64 I. Background Information DIPEPTIDE RESEARCH PROJECT Methods developed by organic chemists for the synthesis of biopolymers have had

More information

2. Couple the two protected amino acids.

2. Couple the two protected amino acids. General Considerations The Strategy of Peptide Synthesis Making peptide bonds between amino acids is not difficult. The challenge is connecting amino acids in the correct sequence. andom peptide bond formation

More information

GCE. Chemistry A. Mark Scheme for June 2012. Advanced GCE. Unit F324: Rings, Polymers and Analysis. Oxford Cambridge and RSA Examinations

GCE. Chemistry A. Mark Scheme for June 2012. Advanced GCE. Unit F324: Rings, Polymers and Analysis. Oxford Cambridge and RSA Examinations GE hemistry A Advanced GE Unit F324: Rings, Polymers and Analysis Mark Scheme for June 2012 Oxford ambridge and RSA Examinations OR (Oxford ambridge and RSA) is a leading UK awarding body, providing a

More information

The Experiment Some nuclei have nuclear magnetic moments; just as importantly, some do not

The Experiment Some nuclei have nuclear magnetic moments; just as importantly, some do not Chemistry 2600 Lecture Notes Chapter 15 Nuclear Magnetic Resonance Spectroscopy Page 1 of 23 Structure Determination in Organic Chemistry: NMR Spectroscopy Three main techniques are used to determine the

More information

Proton Nuclear Magnetic Resonance Spectroscopy

Proton Nuclear Magnetic Resonance Spectroscopy Proton Nuclear Magnetic Resonance Spectroscopy Introduction: The NMR Spectrum serves as a great resource in determining the structure of an organic compound by revealing the hydrogen and carbon skeleton.

More information

But in organic terms: Oxidation: loss of H 2 ; addition of O or O 2 ; addition of X 2 (halogens).

But in organic terms: Oxidation: loss of H 2 ; addition of O or O 2 ; addition of X 2 (halogens). Reactions of Alcohols Alcohols are versatile organic compounds since they undergo a wide variety of transformations the majority of which are either oxidation or reduction type reactions. Normally: Oxidation

More information

Solving Spectroscopy Problems

Solving Spectroscopy Problems Solving Spectroscopy Problems The following is a detailed summary on how to solve spectroscopy problems, key terms are highlighted in bold and the definitions are from the illustrated glossary on Dr. Hardinger

More information

A LEVEL. Type of resource H433 CHEMISTRY B. Theme: Carbon-13 MMR. October 2015

A LEVEL. Type of resource H433 CHEMISTRY B. Theme: Carbon-13 MMR. October 2015 A LEVEL Type of resource H433 CHEMISTRY B (SALTERS) Theme: Carbon-13 MMR October 2015 We will inform centres about any changes to the specification. We will also publish changes on our website. The latest

More information

Determining the Structure of an Organic Compound

Determining the Structure of an Organic Compound Determining the Structure of an Organic Compound The analysis of the outcome of a reaction requires that we know the full structure of the products as well as the reactants In the 19 th and early 20 th

More information

NMR SPECTROSCOPY. Basic Principles, Concepts, and Applications in Chemistry. Harald Günther University of Siegen, Siegen, Germany.

NMR SPECTROSCOPY. Basic Principles, Concepts, and Applications in Chemistry. Harald Günther University of Siegen, Siegen, Germany. NMR SPECTROSCOPY Basic Principles, Concepts, and Applications in Chemistry Harald Günther University of Siegen, Siegen, Germany Second Edition Translated by Harald Günther JOHN WILEY & SONS Chichester

More information

Prof. Dr. Burkhard König, Institut für Organische Chemie, Uni Regensburg 1. Enolate Chemistry

Prof. Dr. Burkhard König, Institut für Organische Chemie, Uni Regensburg 1. Enolate Chemistry Prof. Dr. Burkhard König, Institut für rganische Chemie, Uni Regensburg 1 1. Some Basics Enolate Chemistry In most cases the equilibrium lies almost completely on the side of the ketone. The ketone tautomer

More information

Boston University Dresden Science Program ORGANIC CHEMISTRY CAS CH 203 Lecture

Boston University Dresden Science Program ORGANIC CHEMISTRY CAS CH 203 Lecture Boston University Dresden Science Program ORGANIC CHEMISTRY CAS CH 203 Lecture Instructor: Professor Wolf D. Habicher, Professor Claus Rüger Meeting Times Lectures: twice a week at 90 minutes each Discussions:

More information

Chapter 13 Spectroscopy NMR, IR, MS, UV-Vis

Chapter 13 Spectroscopy NMR, IR, MS, UV-Vis Chapter 13 Spectroscopy NMR, IR, MS, UV-Vis Main points of the chapter 1. Hydrogen Nuclear Magnetic Resonance a. Splitting or coupling (what s next to what) b. Chemical shifts (what type is it) c. Integration

More information

1 General introduction

1 General introduction General introduction Peptides and peptidomimetics _ 1 1 General introduction 1.1 Peptides and peptidomimetics umerous small and large peptides, which are sequence and length-specific polymers composed

More information

Chemistry and Environmental Science

Chemistry and Environmental Science New Jersey Institute of Technology 1 Chemistry and Environmental Science NJIT's Department of Chemistry and Environmental Science provides a unique focus for addressing some of today's most pressing scientific

More information

USP's Therapeutic Peptides Expert Panel discusses manufacturing processes and impurity control for synthetic peptide APIs.

USP's Therapeutic Peptides Expert Panel discusses manufacturing processes and impurity control for synthetic peptide APIs. Control Strategies for Synthetic Therapeutic Peptide APIs Part III: Manufacturing Process Considerations By Brian Gregg,Aleksander Swietlow,Anita Y. Szajek,Harold Rode,Michael Verlander,Ivo Eggen USP's

More information

Experimental procedures. Solid phase peptide synthesis (SPPS)

Experimental procedures. Solid phase peptide synthesis (SPPS) Electronic Supplementary Material (ESI) for Organic & Biomolecular Chemistry This journal is The Royal Society of Chemistry 214 Experimental procedures Solid phase peptide synthesis (SPPS) Solid phase

More information

Infrared Spectroscopy 紅 外 線 光 譜 儀

Infrared Spectroscopy 紅 外 線 光 譜 儀 Infrared Spectroscopy 紅 外 線 光 譜 儀 Introduction Spectroscopy is an analytical technique which helps determine structure. It destroys little or no sample (nondestructive method). The amount of light absorbed

More information

Department of Chemistry, Delaware State University

Department of Chemistry, Delaware State University Department of Chemistry, Delaware State University Syllabus: ORGANIC CHEMISTRY II - 18042 - CHEM 211 01 (Spring 2016) 1. Course Information CRN 18042 Credit 3 Class Time M/W/R, 12:00 PM 12:50 PM Class

More information

Mt. San Antonio College

Mt. San Antonio College Green Organic Chemistry @ Mt. SAC Mt. San Antonio College Walnut, California Iraj B. Nejad inejad@mtsac.edu 210 th 2YC3 Conference Chemistry for a Sustainable Future Kaneohe, Hawaii May 22-23, 2015 Mt.

More information

F322: Chains, Energy and Resources 2.2.4 Alcohols

F322: Chains, Energy and Resources 2.2.4 Alcohols F322: hains, Energy and Resources 2.2.4 Alcohols 167 marks 1. This question is about the six alcohols below. butan-2-ol 2-methylpentan-3-ol propan-1-ol ethane-1,2-diol 2-methylpropan-2-ol propan-2-ol Which

More information

Proton Nuclear Magnetic Resonance ( 1 H-NMR) Spectroscopy

Proton Nuclear Magnetic Resonance ( 1 H-NMR) Spectroscopy Proton Nuclear Magnetic Resonance ( 1 H-NMR) Spectroscopy Theory behind NMR: In the late 1940 s, physical chemists originally developed NMR spectroscopy to study different properties of atomic nuclei,

More information

13C NMR Spectroscopy

13C NMR Spectroscopy 13 C NMR Spectroscopy Introduction Nuclear magnetic resonance spectroscopy (NMR) is the most powerful tool available for structural determination. A nucleus with an odd number of protons, an odd number

More information

Name Key 215 F12-Exam No. 2 Page 2

Name Key 215 F12-Exam No. 2 Page 2 ame Key 15 F1-Exam o. Page. (9 points) For each of the following sets of molecules, rank the molecules in order of to least acidic. ompare the underlined s for each set. (a) (b) (c). (11 points) Draw in

More information

CHEMISTRY. Real. Amazing. Program Goals and Learning Outcomes. Preparation for Graduate School. Requirements for the Chemistry Major (71-72 credits)

CHEMISTRY. Real. Amazing. Program Goals and Learning Outcomes. Preparation for Graduate School. Requirements for the Chemistry Major (71-72 credits) CHEMISTRY UW-PARKSIDE 2015-17 CATALOG Greenquist 344 262-595-2326 College: Natural and Health Sciences Degree and Programs Offered: Bachelor of Science Major - Chemistry Minor - Chemistry Certificate -

More information

Reactions of Aldehydes and Ketones

Reactions of Aldehydes and Ketones Reactions of Aldehydes and Ketones Structure Deduction using lassification Tests 1 Determination of Structure Determining the structure of an unknown organic compound is an exercise in deductive reasoning.

More information

Guide to the Chemistry Major at Johns Hopkins

Guide to the Chemistry Major at Johns Hopkins Guide to the Chemistry Major at Johns Hopkins 1 Welcome to the Chemistry Major at Johns Hopkins. Chemistry is a broad field that encompasses both physics and biology with traditional areas of chemistry

More information

Chapter 11 Homework and practice questions Reactions of Alkyl Halides: Nucleophilic Substitutions and Eliminations

Chapter 11 Homework and practice questions Reactions of Alkyl Halides: Nucleophilic Substitutions and Eliminations Chapter 11 Homework and practice questions Reactions of Alkyl Halides: Nucleophilic Substitutions and Eliminations SHORT ANSWER Exhibit 11-1 Circle your response in each set below. 1. Circle the least

More information

Lehigh University CHEM 112 ORGANIC CHEMISTRY II Spring 2016 Course Syllabus. Instructors:

Lehigh University CHEM 112 ORGANIC CHEMISTRY II Spring 2016 Course Syllabus. Instructors: Lehigh University CHEM 112 ORGANIC CHEMISTRY II Spring 2016 Course Syllabus Instructors: Name: Robert Flowers, Ph.D. Name: Suzanne M. Fernandez, Ph.D. Office: room 796 Mudd Office: room 692 Mudd Phone:

More information

INTI COLLEGE MALAYSIA A? LEVEL PROGRAMME CHM 111: CHEMISTRY MOCK EXAMINATION: DECEMBER 2000 SESSION. 37 74 20 40 60 80 m/e

INTI COLLEGE MALAYSIA A? LEVEL PROGRAMME CHM 111: CHEMISTRY MOCK EXAMINATION: DECEMBER 2000 SESSION. 37 74 20 40 60 80 m/e CHM111(M)/Page 1 of 5 INTI COLLEGE MALAYSIA A? LEVEL PROGRAMME CHM 111: CHEMISTRY MOCK EXAMINATION: DECEMBER 2000 SESSION SECTION A Answer ALL EIGHT questions. (52 marks) 1. The following is the mass spectrum

More information

Ultraviolet Spectroscopy

Ultraviolet Spectroscopy Ultraviolet Spectroscopy The wavelength of UV and visible light are substantially shorter than the wavelength of infrared radiation. The UV spectrum ranges from 100 to 400 nm. A UV-Vis spectrophotometer

More information

Chemistry CHEMISTRY. 2015-16 Sacramento City College Catalog. Degrees: A.S. Chemistry A.S. Chemical Technology

Chemistry CHEMISTRY. 2015-16 Sacramento City College Catalog. Degrees: A.S. Chemistry A.S. Chemical Technology CHEM Degrees: A.S. A.S. Chemical Technology Certificate of Achievement: Chemical Technology Associate in Science Degree Program Information is the study of the properties, composition, and transformations

More information

Examination of Proton NMR Spectra

Examination of Proton NMR Spectra Examination of Proton NMR Spectra What to Look For 1) Number of Signals --- indicates how many "different kinds" of protons are present. 2) Positions of the Signals --- indicates something about magnetic

More information

Used to determine relative location of atoms within a molecule Most helpful spectroscopic technique in organic chemistry Related to MRI in medicine

Used to determine relative location of atoms within a molecule Most helpful spectroscopic technique in organic chemistry Related to MRI in medicine Structure Determination: Nuclear Magnetic Resonance CHEM 241 UNIT 5C 1 The Use of NMR Spectroscopy Used to determine relative location of atoms within a molecule Most helpful spectroscopic technique in

More information

The content is based on the National Science Teachers Association (NSTA) standards and is aligned with state standards.

The content is based on the National Science Teachers Association (NSTA) standards and is aligned with state standards. Literacy Advantage Physical Science Physical Science Literacy Advantage offers a tightly focused curriculum designed to address fundamental concepts such as the nature and structure of matter, the characteristics

More information

l 4-minute cycle time l 90% solvent reduction Remarkably fast Automated Microwave Peptide Synthesizer

l 4-minute cycle time l 90% solvent reduction Remarkably fast Automated Microwave Peptide Synthesizer Automated Microwave Peptide Synthesizer CEM is transforming the way chemists perform peptide synthesis once again with the introduction of the Liberty Blue Microwave Peptide Synthesizer. More than just

More information

ALKENES AND ALKYNES REACTIONS

ALKENES AND ALKYNES REACTIONS A STUDENT SHULD BE ABLE T: ALKENES AND ALKYNES REACTINS 1. Given the starting materials and reaction conditions, predict the products of the following reactions of alkenes and alkynes. Regioselective Markovnikov

More information

CHEMISTRY A. AS and A LEVEL Co-teach Guide. A Guide to co-teaching The OCR A and AS level Chemistry A Specifications. www.ocr.org.

CHEMISTRY A. AS and A LEVEL Co-teach Guide. A Guide to co-teaching The OCR A and AS level Chemistry A Specifications. www.ocr.org. Qualification Accredited Oxford Cambridge and RSA AS and A LEVEL Co-teach Guide CHEMISTRY A H032/H432 For first teaching in 2015 A Guide to co-teaching The OCR A and AS level Chemistry A Specifications

More information

Solution problem 13: Absorption of Light by Molecules

Solution problem 13: Absorption of Light by Molecules Solution problem 13: Absorption of Light by Molecules 13.1 A = εcd = 1.5 10 5 mol -1 L cm -1 4 10-6 mol L -1 10-4 cm = 6 10-5 Since A = log(p 0 /P), the ratio P/P 0 is 0.999862. This is the percentage

More information

MCAT Organic Chemistry - Problem Drill 23: Amino Acids, Peptides and Proteins

MCAT Organic Chemistry - Problem Drill 23: Amino Acids, Peptides and Proteins MCAT rganic Chemistry - Problem Drill 23: Amino Acids, Peptides and Proteins Question No. 1 of 10 Question 1. Which amino acid does not contain a chiral center? Question #01 (A) Serine (B) Proline (C)

More information

NMR SPECTROSCOPY A N I N T R O D U C T I O N T O... Self-study booklet NUCLEAR MAGNETIC RESONANCE. 4 3 2 1 0 δ PUBLISHING

NMR SPECTROSCOPY A N I N T R O D U C T I O N T O... Self-study booklet NUCLEAR MAGNETIC RESONANCE. 4 3 2 1 0 δ PUBLISHING A N I N T R O D U T I O N T O... NMR SPETROSOPY NULEAR MAGNETI RESONANE 4 3 1 0 δ Self-study booklet PUBLISING NMR Spectroscopy NULEAR MAGNETI RESONANE SPETROSOPY Origin of Spectra Theory All nuclei possess

More information

LifeTein in Industrial Production of Therapeutic Peptides. Phil Moore, PhD Director of Business Development LifeTein LLC, NJ, USA

LifeTein in Industrial Production of Therapeutic Peptides. Phil Moore, PhD Director of Business Development LifeTein LLC, NJ, USA LifeTein in Industrial Production of Therapeutic Peptides Phil Moore, PhD Director of Business Development LifeTein LLC, NJ, USA 1 Outline Market and Technology Trend LifeTein s Technology portfolio LifeTein

More information

1) Technical informations. - a) How does it work? - b) Purification - c) Quality Control. 2) Standard synthesis

1) Technical informations. - a) How does it work? - b) Purification - c) Quality Control. 2) Standard synthesis 1) Technical informations - a) How does it work? - b) Purification - c) Quality Control 2) Standard synthesis - a) Standard peptides - b) Modified peptides - c) Shipment and Delivery Time - d) How to order?

More information

INFRARED SPECTROSCOPY (IR)

INFRARED SPECTROSCOPY (IR) INFRARED SPECTROSCOPY (IR) Theory and Interpretation of IR spectra ASSIGNED READINGS Introduction to technique 25 (p. 833-834 in lab textbook) Uses of the Infrared Spectrum (p. 847-853) Look over pages

More information

T3P Propane Phosphonic Acid Anhydride

T3P Propane Phosphonic Acid Anhydride Technology StrengthS T3P Propane Phosphonic Acid Anhydride The coupling agent of the future Coupling and water removal are synthesis tools that stand at the cutting edge of purity and cost effective manufacture

More information

Carboxylic Acid Derivatives and Nitriles

Carboxylic Acid Derivatives and Nitriles Carboxylic Acid Derivatives and itriles Carboxylic Acid Derivatives: There are really only four things to worry about under this heading; acid chlorides, anhydrides, esters and amides. We ll start with

More information

The Citric Acid Cycle

The Citric Acid Cycle The itric Acid ycle February 14, 2003 Bryant Miles I. itrate Synthase + 3 SoA The first reaction of the citric acid cycle is the condensation of acetyloa and oxaloacetate to form citrate and oas. The enzyme

More information

Nuclear Magnetic Resonance Spectroscopy

Nuclear Magnetic Resonance Spectroscopy Nuclear Magnetic Resonance Spectroscopy Introduction NMR is the most powerful tool available for organic structure determination. It is used to study a wide variety of nuclei: 1 H 13 C 15 N 19 F 31 P 2

More information

Everything You Need to Know About Mechanisms. First rule: Arrows are used to indicate movement of electrons

Everything You Need to Know About Mechanisms. First rule: Arrows are used to indicate movement of electrons Everything You eed to Know About Mechanisms A) The orrect Use of Arrows to Indicate Electron Movement The ability to write an organic reaction mechanism properly is key to success in organic chemistry

More information

In Situ Spectroscopy. Reaction Analysis and PAT Tools From Research to Manufacturing

In Situ Spectroscopy. Reaction Analysis and PAT Tools From Research to Manufacturing In Situ Spectroscopy Reaction Analysis and PAT Tools From Research to Manufacturing Chemical Synthesis, Engineering and PAT Understanding Reaction Chemistry with ReactIR In Situ Analytical Tools ReactIR

More information

Suggested solutions for Chapter 7

Suggested solutions for Chapter 7 s for Chapter 7 7 PRBLEM 1 Are these molecules conjugated? Explain your answer in any reasonable way. C Et C Et C Et Revision of the basic kinds of conjugation and how to show conjugation with curly arrows.

More information

Symmetric Stretch: allows molecule to move through space

Symmetric Stretch: allows molecule to move through space BACKGROUND INFORMATION Infrared Spectroscopy Before introducing the subject of IR spectroscopy, we must first review some aspects of the electromagnetic spectrum. The electromagnetic spectrum is composed

More information

Southeastern Louisiana University Dual Enrollment Program--Chemistry

Southeastern Louisiana University Dual Enrollment Program--Chemistry Southeastern Louisiana University Dual Enrollment Program--Chemistry The Southeastern Dual Enrollment Chemistry Program is a program whereby high school students are given the opportunity to take college

More information

NMR Spectroscopy of Aromatic Compounds (#1e)

NMR Spectroscopy of Aromatic Compounds (#1e) NMR Spectroscopy of Aromatic Compounds (#1e) 1 H NMR Spectroscopy of Aromatic Compounds Erich Hückel s study of aromaticity in the 1930s produced a set of rules for determining whether a compound is aromatic.

More information

Chemistry Diagnostic Questions

Chemistry Diagnostic Questions Chemistry Diagnostic Questions Answer these 40 multiple choice questions and then check your answers, located at the end of this document. If you correctly answered less than 25 questions, you need to

More information

1. What is the hybridization of the indicated atom in the following molecule?

1. What is the hybridization of the indicated atom in the following molecule? Practice Final Exam, Chemistry 2210, rganic Chem I 1. What is the hybridization of the indicated atom in the following molecule? A. sp 3 B. sp 2 C. sp D. not hybridized 2. Name the functional groups in

More information

BERGEN COMMUNITY COLLEGE DIVISION OF MATHEMATICS, SCIENCE AND TECHNOLOGY DEPARTMENT OF PHYSICAL SCIENCES STUDENT COURSE OUTLINE

BERGEN COMMUNITY COLLEGE DIVISION OF MATHEMATICS, SCIENCE AND TECHNOLOGY DEPARTMENT OF PHYSICAL SCIENCES STUDENT COURSE OUTLINE BERGEN COMMUNITY COLLEGE DIVISION OF MATHEMATICS, SCIENCE AND TECHNOLOGY DEPARTMENT OF PHYSICAL SCIENCES STUDENT COURSE OUTLINE Course Title: Prerequisites: Course Description: Textbook: CHM 212 Organic

More information

A declaration form should be completed online, printed and signed by persons applying for entry to the PME.

A declaration form should be completed online, printed and signed by persons applying for entry to the PME. Page 1 of 10 Professional Master of Education Subject Declaration Form IMPORTANT This declaration form should be returned to the PME provider(s) to which you have applied or the Postgraduate Applications

More information

GCE Chemistry A. Mark Scheme for June 2014. Unit F324: Rings, Polymers and Analysis. Advanced GCE. Oxford Cambridge and RSA Examinations

GCE Chemistry A. Mark Scheme for June 2014. Unit F324: Rings, Polymers and Analysis. Advanced GCE. Oxford Cambridge and RSA Examinations GCE Chemistry A Unit F324: Rings, Polymers and Analysis Advanced GCE Mark Scheme for June 2014 Oxford Cambridge and RSA Examinations OCR (Oxford Cambridge and RSA) is a leading UK awarding body, providing

More information

Overview'of'Solid-Phase'Peptide'Synthesis'(SPPS)'and'Secondary'Structure'Determination'by'FTIR'

Overview'of'Solid-Phase'Peptide'Synthesis'(SPPS)'and'Secondary'Structure'Determination'by'FTIR' verviewofsolid-phasepeptidesynthesis(spps)andsecondarystructuredeterminationbyftir Introduction Proteinsareubiquitousinlivingorganismsandcells,andcanserveavarietyoffunctions.Proteinscanactas enzymes,hormones,antibiotics,receptors,orserveasstructuralsupportsintissuessuchasmuscle,hair,and

More information

Chemistry Course Descriptions

Chemistry Course Descriptions Chemistry Course Descriptions Please note: Course numbers and descriptions are given based on the UCF course offerings, if available. Courses Offered UCF BCC CFCC DBCC LSCC SCC VCC CHM 1015 (Pre-College

More information

4026 Synthesis of 2-chloro-2-methylpropane (tert-butyl chloride) from tert-butanol

4026 Synthesis of 2-chloro-2-methylpropane (tert-butyl chloride) from tert-butanol 4026 Synthesis of 2-chloro-2-methylpropane (tert-butyl chloride) from tert-butanol OH + HCl Cl + H 2 O C 4 H 10 O C 4 H 9 Cl (74.1) (36.5) (92.6) Classification Reaction types and substance classes nucleophilic

More information

INTDUCTIN T LEWIS ACID-BASE CEMISTY DEINITINS Lewis acids and bases are defined in terms of electron pair transfers. A Lewis base is an electron pair donor, and a Lewis acid is an electron pair acceptor.

More information

Nuclear Magnetic Resonance notes

Nuclear Magnetic Resonance notes Reminder: These notes are meant to supplement, not replace, the laboratory manual. Nuclear Magnetic Resonance notes Nuclear Magnetic Resonance (NMR) is a spectrometric technique which provides information

More information