Abbreviations and Symbols

Transcription

1 Abbreviations and Symbols Information on purity and application see [ ] Chemical Abstracts Registry Number (CAS) > more than < less than min max minimum maximum µm 0,001 mm ~ approximate [α]a +4 C -20 C specific rotation storage in refrigerating room storage in deep-freeze room registered symbol, registered trade mark ë í è=/ è+ ç ê=/ ê+ én éi f m l o k h i g n j Å ACS ADR AW Amp. aq art. asym. AT BP bp bp 12 c CAS CELLPURE corrosive explosive highly flammable / extremely flammable fire-activating, oxidizing toxic / very toxic harmful irritant dangerous for the environment GHS01 exploding bomb GHS02 flame GHS03 flame over circle GHS04 gas cylinder GHS05 corrosion GHS06 skull and crossbones exclamation mark GHS08 health hazard GHS09 environment Ångström = m American Chemical Society European agreement on international road transport of hazardous goods atomic weight ampoule water artificial asymmetrical argentometric titration British Pharmacopoeia boiling point, boiling range boiling point at 12 torr amount-of-substance concentration Chemical Abstract Service suitable for cell culture CHR A compound in this catalogue is designated as being thin-layer chromatographically pure (CHR) if no impurities can be detected during test conditions with 20 µg sample. ~CHR For products with impurities which under our conditions, (see CHR), allow the main compound to be designated; such products can be identified as being "almost thin-layer chromatographically pure" (~CHR). C.I. No colour index number conc. concentrated cp centipoise cryst. crystallized cst centistoke D density DAB Deutsches Arzneibuch (German Pharmacopoeia) DAC Deutscher Arzneimittel-Codex (German Drugs Codex) DC thin-layer chromatography dec. decomposition depur. depuratum, purified quality dest. distilled DIN German Industrial Standards E No number codes for food additives that have been assessed for use within the EC EC No the official number of a chemical substance that is commercially available within the EC extra pure suitable for laboratory use F melting point, melting range FCC Food chemical codex FIP Fédération Internationale Pharmaceutique Flp flash point g gramme GC gas chromatography (GC) content defined by gas chromatography H Hazard statement acc. to regulation (EC) No 1272/2008 (CLP, GHS) HPLC high performance liquid chromatography IE international unit (Internationale Einheit) ISO International Organization for Standardization IU international unit JP Japanese Pharmacopoeia kg kilogramme l, ltr litre Lit. literature LSC liquid scintillation counting lyophil. lyophilized (readily soluble form) M or mol/l molarity, amount-of-substance concentration

2 Abbreviations and Symbols M mg ml Mol.% nat. n D o.r. P Pa s p.a. Pestilyse ph pka pharm. Ph.Eur. ppb ppm ppt prim. PUFFERAN pulv. pure puriss. purum molecular weight or molar mass milligramm mililitre molar percent natural refractive index on request Precautionary statement acc. to regulation (EC) No 1272/2008 (CLP, GHS) Pascal second pro analysi = for analytical purposes solvent, suitable for residue analysis (environmental, water and food analysis) ph value pka value pharmaceutical quality, for pharmaceutical purposes European Pharmacopoeia parts per billion = 1 µg per kg parts per million = 0,0001 %, 1 mg per kg parts per trillion = 1 ng per kg primary can be used as buffer pulverised suitable for synthesis and laboratory use purissimum, especially pure quality. Products with such designation have a content of at least 99%, unless a different content is stated in %. Their appearance and characteristic data correspond to the appertaining literature or deviate only slightly from it. They are suitable for purposes requiring a high degree of purity. With a number of products having this degree of purity, analysis certificates plus guarantee will be supplied or attached to the container. Delicate products are packaged under protective gas. chemically pure quality. Products having the purity designation "purum" have a content of at least 97%, unless a different content is stated, and their colour and characteristic data, apart from minor deviations, correspond to the literature. This degree of purity is recommended for laboratory work such as syntheses, which are subject to purity requirements. Delicate products are packaged under protective gas. ROTICUBE ROTIDRY ROTIDRY SEPT ROTIGEN ROTIPHORESE ROTIPURAN ROTISOLV ROTITAINER S sec. sicc. sine H 2 O stab. subl. sym. synth. techn. tert. TLC U USP WGK WGK 1 WGK 2 WGK 3 Combi-box of 5 litre or 10 litre, consisting of a stable outer card box with inner bag made of PE; comes with stopcock. dried solvents, filled under protective gas dried solvents, in a septum bottle product is suitable for DNA-synthesis product is suitable for electrophoresis highly pure product solvent for specific use - brand name Roth Stackable containers which can also be handled easily by female workers. Matching safety pumps are available. Solid substances are delivered in plastic buckets. Safety statement acc. to regulation 67/548/EEC secondary dry, anhydrous (siccus) water free stabilized sublimated symmetrical synthetic technical quality. Products with the purity designation "technicum" feature a different content. They are generally mass produced and may have a slightly foreign odour and colour. They are used for general technical purposes. tertiary; standard for thin-layer chromatograhy (TLC) thin layer chromatography unit United States Pharmacopoeia water hazard class generally not water hazardous water hazardous extremely water hazardous R Risk statement acc. to regulation 67/548/EEC rect. rectification redest. redistilled resubl. resublimated ROTICHROM suitable as standard in chromatography ROTICHROM GC reference substance for gas chromatography, delivered with GC chromatogram ROTICHROM HPLC reference substance for HPLC, delivered with HPLC chromatogram ROTICHROM TLC reference substance for thin-layer chromatography, delivered with thin-layer chromatogram

3 Labelling acc. to Regulation 67/548/EEC Symbols Risk-phrases Safety-phrases ê T+ ê T é Xn ë C é Xi í E ç O è F+ è F Very toxic 26, 27, 28, 39 1, 4, 13, 20, 21, 22, 27, 28, 29, 35, 36, 37, 38, 45 Toxic 23, 24, 25, 39, 45, 46, 48, 49, 60, 61 1, 4, 13, 20, 21, 22, 27, 28, 35, 36, 37, 38, 45 Harmful 20, 21, 22, 40, 42, 46, 48, 60, 61, 62, 63, 64, 65, 68 2, 13, 36, 37, 45 Corrosive 34, 35 2, 18, 20, 25, 26, 27, 28, 37, 39, 45 Irritant 36, 37, 38, 41, 43 2, 18, 24, 25, 26, 27, 28, 37, 39, 45 Explosive 1, 2, 3, 4, 5, 6, 16 1, 2, 3, 4, 35, (7, 9, 14, 25, 27, 39, 50) Oxidizing 7, 8, 9 2, 14, 25, 40, 50 Extremely flammable 12 2, 3, 9, 15, 16, 29, 33, 43 Highly flammable 11, 15, 17 2, 3, 9, 16, 29, 33 f N ous for the environment 50, 51, 52, 53, 54, 55, 56, 57, 58, 59 29, 56, 57, 59, 60, 61

4 R+S-Phrases R-Phrases R 1: R 2: R 3: R 4: R 5: R 6: R 7: R 8: R 9: R 10: R 11: R 12: R 14: R 15: R 16: R 17: R 18: R 19: R 20: R 21: R 22: R 23: R 24: R 25: R 26: R 27: R 28: R 29: R 30: R 31: R 32: R 33: R 34: R 35: R 36: R 37: R 38: R 39: R 40: R 41: R 42: R 43: R 44: R 45: R 46: Explosive when dry. Risk of explosion by shock, friction, fire or other sources of ignition. Extreme risk of explosion by shock, friction, fire or other sources of ignition. Forms very sensitive explosive metallic compounds. Heating may cause an explosion. Explosive with or without contact with air. May cause fire. Contact with combustible material may cause fire. Explosive when mixed with combustible material. Flammable. Highly flammable. Extremely flammable. Reacts violently with water. Contact with water liberates extremely flammable gases. Explosive when mixed with oxidizing substances. Spontaneously flammable in air. In use, may form flammable/explosive vapour air mixture. May form explosive peroxides. Harmful by inhalation. Harmful in contact with skin. Harmful if swallowed. Toxic by inhalation. Toxic in contact with skin. Toxic if swallowed. Very toxic by inhalation. Very toxic in contact with skin. Very toxic if swallowed. Contact with water liberates toxic gas. Can become highly flammable in use. Contact with acids liberates toxic gas. Contact with acids liberates very toxic gas. of cumulative effects. Causes burns. Causes severe burns. Irritating to eyes. Irritating to respiratory system. Irritating to skin. of very serious irreversible effects. Limited evidence of a carcinogenic effect. Risk of serious damage to eyes. May cause sensitization by inhalation. May cause sensitization by skin contact. Risk of explosion if heated under confinement. May cause cancer. May cause heritable genetic damage. R 48: R 49: R 50: R 51: R 52: R 53: R 54: R 55: R 56: R 57: R 58: R 59: R 60: R 61: R 62: R 63: R 64: R 65: R 66: R 67: R 68: of serious damage to health by prolonged exposure. May cause cancer by inhalation. Very toxic to aquatic organisms. Toxic to aquatic organisms. Harmful to aquatic organisms. May cause long-term adverse effects in the aquatic environment. Toxic to flora. Toxic to fauna. Toxic to soil organisms. Toxic to bees. May cause long-term adverse effects in the environment. ous for the ozone layer. May impair fertility. May cause harm to the unborn child. Possible risk of impaired fertility. Possible risk of harm to the unborn child. May cause harm to breastfed babies. Harmful: may cause lung damage if swallowed. Repeated exposure may cause skin dryness or cracking. Vapours may cause drowsiness and dizziness. Possible risk of irreversible effects. Combination of R-Phrases R14/15: R 15/29: R 20/21: R 20/22: R 20/21/22: R 21/22: R 23/24: R 23/25: R 23/24/25: R 24/25: R 26/27: R 26/28: R 26/27/28: R 27/28: R 36/37: R 36/38: R 36/37/38: R 37/38: R 39/23: R 39/24: Reacts violently with water, liberating extremely flammable gases. Contact with water liberates toxic, extremely flammable gas. Harmful by inhalation and in contact with skin. Harmful by inhalation and if swallowed. Harmful by inhalation, in contact with skin and if swallowed. Harmful in contact with skin and if swallowed. Toxic by inhalation and in contact with skin. Toxic by inhalation and if swallowed. Toxic by inhalation, in contact with skin and if swallowed. Toxic in contact with skin and if swallowed. Very toxic by inhalation and in contact with skin. Very toxic by inhalation and if swallowed. Very toxic by inhalation, in contact with skin and if swallowed. Very toxic in contact with skin and if swallowed. Irritating to eyes and respiratory system. Irritating to eyes and skin. Irritating to eyes, respiratory system and skin. Irritating to respiratory system and skin. Toxic : danger of very serious irreversible effects through inhalation. Toxic : danger of very serious irreversible effects in contact with skin.

5 R+S-Phrases R 39/25: R 39/23/24: R 39/23/25: R 39/24/25: R 39/23/24/25: R 39/26: R 39/27: R 39/28: R 39/26/27: R 39/26/28: R 39/27/28: R 39/26/27/28: R 42/43: R 48/20: R 48/21: R 48/22: R 48/20/21: R 48/20/22: R 48/21/22: R 48/20/21/22: R 48/23: R 48/24: R 48/25: R 48/23/24: R 48/23/25: R 48/24/25: R 48/23/24/25: Toxic : danger of very serious irreversible effects if swallowed. Toxic : danger of very serious irreversible effects through inhalation and in contact with skin. Toxic : danger of very serious irreversible effects through inhalation and if swallowed. Toxic : danger of very serious irreversible effects in contact with skin and if swallowed. Toxic : danger of very serious irreversible effects through inhalation, in contact with skin and if swallowed. Very toxic : danger of very serious irreversible effects through inhalation. Very toxic : danger of very serious irreversible effects in contact with skin. Very toxic : danger of very serious irreversible effects if swallowed. Very toxic : danger of very serious irreversible effects through inhalation and in contact with skin. Very toxic : danger of very serious irreversible effects through inhalation and if swallowed. Very toxic : danger of very serious irreversible effects in contact with skin and if swallowed. Very toxic : danger of very serious irreversible effects through inhalation, in contact with skin and if swallowed. May cause sensitization by inhalation and skin contact. exposure through inhalation exposure in contact with skin. exposure if swallowed. exposure through inhalation and in contact with skin. exposure through inhalation and if swallowed. exposure in contact with skin and if swallowed. exposure through inhalation, in contact with skin and if swallowed. exposure through inhalation. exposure in contact with skin. exposure if swallowed. exposure through inhalation and in contact with skin. exposure through inhalation and if swallowed. exposure in contact with skin and if swallowed. exposure through inhalation, in contact with skin and if swallowed. R 50/53: R 51/53: R 52/53: R 68/20: R 68/20/21: R 68/20/21/22: R 68/20/22: R 68/21: R 68/21/22: R 68/22: S-Phrases Very toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment. Toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment. Harmful to aquatic organisms, may cause long-term adverse effects in the aquatic environment. Harmful : possible risk of irreversible effects through inhalation. Harmful : possible risk of irreversible effects through inhalation and in contact with skin. Harmful : possible risk of irreversible effects through inhalation, in contact with skin and if swallowed. Harmful : possible risk of irreversible effects through inhalation and if swallowed. Harmful : possible risk of irreversible effects in contact with skin. Harmful : possible risk of irreversible effects in contact with skin and if swallowed. Harmful : possible risk of irreversible effects if swallowed. S1: Keep locked up. S2: Keep out of the reach of children. S3: Keep in a cool place. S4: Keep away from living quarters. S5: Keep contents under... (appropriate liquid to be specified by the manufacturer). S6: Keep under...(inert gas to be specified by the manufacturer). S7: Keep container tightly closed. S8: Keep container dry. S9: Keep container in a well-ventilated place. S12: Do not keep the container sealed. S13: Keep away from food, drink and animal feeding stuffs. S14: Keep away from... (incompatible materials to be indicated by the manufacturer). S15: Keep away from heat. S16: Keep away from sources of ignition - No smoking. S17: Keep away from combustible material. S18: Handle and open container with care. S20: When using do not eat or drink. S21: When using do not smoke. S22: Do not breathe dust. S23: Do not breathe gas/fumes/vapour/spray (appropriate wording to be specified by the manufacturer). S24: Avoid contact with skin. S25: Avoid contact with eyes. S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S27: Take off immediately all contaminated clothing. S28: After contact with skin, wash immediately with plenty of... (to be specified by the manufacturer).

6 R+S-Phrases S29: Do not empty into drains. S30: Never add water to this product. S33: Take precautionary measures against static discharges. S35: This material and its container must be disposed of in a safe way. S36: Wear suitable protective clothing. S37: Wear suitable gloves. S38: In case of insufficient ventilation, wear suitable respiratory equipment. S39: Wear eye/face protection. S40: To clean the floor and all objects contaminated by this material, use... (to be specified by the manufacturer). S41: In case of fire and/or explosion do not breathe fumes. S42: During fumigation/spraying wear suitable respiratory equipment (appropriate wording to be specified by the manufacturer). S43: In case of fire, use... (indicate in the space the precise type of fire-fighting equipment. If water increases risk, add - Never use water ). S45: In case of accident or if you feel unwell, seek medical advice immediately (show te label where possible). S46: If swallowed, seek medical advice immediately and show this container or label. S47: Keep at temperature not exceeding... C (to be specified by the manufacturer). S48 Keep wet with... (appropriate material to be specified by the manufacturer). S49: Keep only in the original container. S50: Do not mix with... (to be specified by the manufacturer). S51: Use only in well-ventilated areas. S52: Not recommended for interior use on large surface areas. S53: Avoid exposure - obtain special instructions before use. S56: Dispose of, this material and its container at hazardous or special waste collection point. S57: Use appropriate container to avoid environmental contamination. S59 Refer to manufacturer/supplier for information on recovery/ recycling. S60: This material and its container must be disposed of as hazardous waste. S61: Avoid release to the environment. Refer to special instructions/safety data sheets. S62: If swallowed, do not induce vomiting : seek medical advice immediately and show this container or label. S63: In case of accident by inhalation : remove casualty to fresh air and keep at rest. S64: If swallowed, rinse mouth with water (only if the person is conscious). Combination of S-Phrases S 1/2 Keep locked up and out of the reach of children. S 3/7 Keep container tightly closed in a cool place. S 3/9/14 Keep in a cool, well-ventilated place away from... (incompatible materials to be indicated by the manufacturer). S 3/9/14/49 Keep only in the original container in a cool, well-ventilated place away from... (incompatible materials to be indicated by the manufacturer). S 3/9/49 Keep only in the original container in a cool, well-ventilated place. S 3/14 Keep in a cool place away from... (incompatible materials to be indicated by the manufacturer). S 7/8 Keep container tightly closed and dry. S 7/9 Keep container tightly closed and in a well-ventilated place. S 7/47 Keep container tightly closed and at a temperature not exceeding... C (to be specified by the manufacturer). S 20/21 When using do not eat, drink or smoke. S 24/25 Avoid contact with skin and eyes. S 27/28 After contact with skin, take off immediately all contaminated clothing, and wash immediately with plenty of - (to be specified by the manufacturer). S 29/35 Do not empty into drains; dispose of this material and its container in a safe way. S 29/56 Do not empty into drains, dispose of this material and its container at hazardous or special waste collection point. S 36/37 Wear suitable protective clothing and gloves. S 36/37/39 Wear suitable protective clothing, gloves and eye/face protection. S 36/39 Wear suitable protective clothing and eye/face protection. S 37/39 Wear suitable gloves and eye/face protection. S 47/49 Keep only in the original container at a temperature not inhalation and in contact with skin.

7 Classification & Labelling acc. to (EC) 1272/2008 Hazard Pictograms The hazard pictogram on the designation label indicates the main hazard arising from a substance. If there are several hazardous qualitiies, several symbols are necessary. Each pictogram is allocated a hazard designation and coding that do not appear on the designation label. GHS01 exploding bomb GHS02 flame GHS03 flame over circle GHS04 gas cylinder GHS05 corrosion GHS06 skull and crossbones Hazard Statements H Codes Hazard statements for physical hazards H200 H201 H202 H203 H204 H205 H220 H221 H222 H223 H224 H225 H226 H228 H229 H230 H231 H240 H241 H242 H250 H251 H252 H260 H261 H270 H271 H272 H280 H281 H290 Unstable explosives. Explosive; mass explosion hazard. Explosive, severe projection hazard. Explosive; fire, blast or projection hazard. Fire or projection hazard. May mass explode in fire. Extremely flammable gas. Flammable gas. Extremely flammable aerosol. Flammable aerosol. Extremely flammable liquid and vapour.j Highly flammable liquid and vapour. Flammable liquid and vapour. Flammable solid. Pressurised container: May burst if heated. May react explosively even in the absence of air. May react explosively even in the absence of air at elevated pressure and/or temperature. Heating may cause an explosion. Heating may cause a fire or explosion. Heating may cause a fire. Catches fire spontaneously if exposed to air. Self-heating; may catch fire. Self-heating in large quantities; may catch fire. In contact with water releases flammable gases which may ignite spontaneously. In contact with water releases flammable gases. May cause or intensify fire; oxidiser. May cause fire or explosion; strong oxidiser. May intensify fire; oxidiser. Contains gas under pressure; may explode if heated. Contains refrigerated gas; may cause cryogenic burns or injury. May be corrosive to metals. exclamation mark GHS08 health hazard GHS09 environment Hazard statements for health hazards H300 Fatal if swallowed. H301 Toxic if swallowed. H302 Harmful if swallowed. H304 May be fatal if swallowed and enters airways. H310 Fatal in contact with skin. H311 Toxic in contact with skin. H312 Harmful in contact with skin. H314 Causes severe skin burns and eye damage. H315 Causes skin irritation. H317 May cause an allergic skin reaction. H318 Causes serious eye damage. H319 Causes serious eye irritation.

8 Classification & Labelling acc. to (EC) 1272/2008 H330 H331 H332 H334 H335 H336 H340 H341 H350 H350i H351 H360 H360F H360D H360FD H360Fd H360Df H361 Fatal if inhaled. Toxic if inhaled. Harmful if inhaled. May cause allergy or asthma symptoms or breathing difficulties if inhaled. May cause respiratory irritation. May cause drowsiness or dizziness. May cause genetic defects. Suspected of causing genetic defects. May cause cancer. May cause cancer by inhalation. Suspected of causing cancer. May damage fertility or the unborn child. May damage fertility. May damage the unborn child. May damage fertility. May damage the unborn child. May damage fertility. Suspected of damaging the unborn child. May damage the unborn child. Suspected of damaging fertility. Suspected of damaging fertility or the unborn child. H361f Suspected of damaging fertility. H361d H361fd H362 H370 H371 H372 H373 Suspected of damaging the unborn child. Suspected of damaging fertility. Suspected of damaging the unborn child. May cause harm to breast-fed children. Causes damage to organs. May cause damage to organs. Causes damage to organs through prolonged or repeated exposure. May cause damage to organs through prolonged or repeated exposure. H300+H310 Fatal if swallowed or in contact with skin. H300+H330 Fatal if swallowed or if inhaled. H310+H330 Fatal in contact with skin or if inhaled. H300+H310+H330 Fatal if swallowed, in contact with skin or if inhaled. H301+H311 Toxic if swallowed or in contact with skin. H301+H331 Toxic if swallowed or if inhaled. H311+H331 Toxic in contact with skin or if inhaled. H301+H311+H331 Toxic if swallowed, in contact with skin or if inhaled. H302+H312 Harmful if swallowed or in contact with skin. H302+H332 Harmful if swallowed or if inhaled. H312+H332 Harmful in contact with skin or if inhaled. H302+H312+H332 Harmful if swallowed, in contact with skin or if inhaled. Supplemental Hazard Information H Codes EUH001 EUH006 EUH014 EUH018 EUH019 EUH029 EUH031 EUH032 EUH044 EUH066 EUH070 EUH071 EUH201 EUH201A EUH202 EUH203 EUH204 EUH205 EUH206 EUH207 EUH208 EUH209 EUH209A EUH210 EUH401 Explosive when dry. Explosive with or without contact with air. Reacts violently with water. In use may form flammable/explosive vapour-air mixture. May form explosive peroxides. Contact with water liberates toxic gas. Contact with acids liberates toxic gas. Contact with acids liberates very toxic gas. Risk of explosion if heated under confinement. Repeated exposure may cause skin dryness or cracking. Toxic by eye contact. Corrosive to the respiratory tract. Contains lead. Should not be used on surfaces liable to be chewed or sucked by children. Warning! Contains lead. Cyanoacrylate.. Bonds skin and eyes in seconds. Keep out of the reach of children. Contains chromium (VI). May produce an allergic reaction. Contains isocyanates. May produce an allergic reaction. Contains epoxy constituents. May produce an allergic reaction. Warning! Do not use together with other products. May release dangerous gases (chlorine). Warning! Contains cadmium. ous fumes are formed during use. See information supplied by the manufacturer. Comply with the safety instructions. Contains (name of sensitising substance). May produce an allergic reaction. Can become highly flammable in use. Can become flammable in use. Safety data sheet available on request. To avoid risks to human health and the environment, comply with the instructions for use. Hazard statements for environmental hazards H400 H410 H411 H412 H413 H420 Very toxic to aquatic life. Very toxic to aquatic life with long lasting effects. Toxic to aquatic life with long lasting effects. Harmful to aquatic life with long lasting effects. May cause long lasting harmful effects to aquatic life. Harms public health and the environment by destroying ozone in the upper atmosphere.

9 Classification & Labelling acc. to (EC) 1272/2008 Classification Labelling Hazard class Category codes Pictogram, code Signal word Hazard statements Unstable Unst. Expl. H200 Unstable explosives. explosives Divisions 1.1 Expl. 1.1 H201 Explosive; mass explosion hazard. Divisions 1.2 Expl. 1.2 H202 Explosive, severe projection hazard. Explosive Divisions 1.3 Expl. 1.3 GHS01 H203 Explosive; fire, blast or projection hazard. Divisions 1.4 Expl. 1.4 Warning H204 Fire or projection hazard. Divisions 1.5 Expl. 1.5 No pictogram H205 May mass explode in fire. Divisions 1.6 Expl. 1.6 No pictogram, no signal word, no hazard statement Flammable gas Category 1 Flam. gas 1 H220 Extremely flammable gas. GHS02 Category 2 Flam. gas 2 No pictogram Warning H221 Flammable gas. Flammable aerosol Category 1 Flam. aerosol 1 H222 Extremely flammable aerosol. Category 2 Flam. aerosol 2 GHS02 Warning H223 Flammable aerosol. Oxidising gas Category 1 Ox. gas 1 H270 May cause or intensify fire; oxidiser. GHS03 Compressed gas Gas under pressure Dissolved gas Liquefied gas Press. gas Warning H280 Contains gas under pressure; may explode if heated. Refrigerated liquefied gas GHS04 H281 Contains refrigerated gas; may cause cryogenic burns or injury. Flammable liquid Category 1 Flam. Liq. 1 H224 Extremely flammable liquid and vapour. Category 2 Flam. Liq. 2 H225 Highly flammable liquid and vapour. Category 3 Flam. Liq. 3 Warning H226 Flammable liquid and vapour. Flammable solid Category 1 Flam. Sol. 1 GHS02 Category 2 Flam. Sol. 2 Warning H228 Flammable solid.

10 Classification & Labelling acc. to (EC) 1272/2008 Classification Labelling Hazard class Category codes Pictogram, code Signal word Hazard statements Self-react. A Type A H240 Heating may cause an explosion. Org. Perox. A GHS01 Self-reactive substance or mixture Type B Self-react. B H241 Heating may cause a fire or explosion. Org. Perox. B GHS01 + GHS02 Organic peroxide Type C and D Type E and F Self-react. CD Org. Perox. CD Self-react. EF Org. Perox. EF GHS02 Warning H242 Heating may cause a fire. Type G Self-react. G Org. Perox. G No pictogram, no signal word, no hazard statement Pyrophoric liquid Category 1 Pyr. Liq. 1 Pyrophoric solid Category 1 Pyr. Sol. 1 H250 Catches fire spontaneously if exposed to air. Self-heating substance or mixture Substance or mixture which in contact with water emits flammable gas Category 1 Self-heat. 1 H251 Self-heating; may catch fire. Category 2 Self-heat. 2 Warning H252 Self-heating in large quantities; may catch fire. Category 1 Water-react. 1 H260 GHS02 Category 2 Water-react. 2 Category 3 Water-react. 3 Warning H261 In contact with water releases flammable gases which may ignite spontaneously. In contact with water releases flammable gases. Oxidising liquid Oxidising solid Category 1 Category 2 Category 3 Ox. Liq. 1 Ox. Sol. 1 Ox. Liq. 2 Ox. Sol. 2 Ox. Liq. 3 Ox. Sol. 3 GHS03 H271 May cause fire or explosion; strong oxidiser. H272 May intensify fire; oxidiser. Warning Substance or mixture corrosive to metals Category 1 Met. Corr. 1 Warning H290 May be corrosive to metals. GHS05 Category 1 Acute Tox. 1 Category 2 Acute Tox. 2 H300 H310 H330 Fatal if swallowed. Fatal in contact with skin. Fatal if inhaled. Acute toxicity Category 3 Acute Tox. 3 GHS06 H301 H311 H331 Toxic if swallowed. Toxic in contact with skin. Toxic if inhaled. Category 4 Acute Tox. 4 Warning H302 H312 H332 Harmful if swallowed. Harmful in contact with skin. Harmful if inhaled.

11 Classification & Labelling acc. to (EC) 1272/2008 Classification Labelling Hazard class Category codes Pictogram, code Signal word Hazard statements Category 1A Skin Corr. 1A Category 1B Skin Corr. 1B H314 Causes severe skin burns and eye damage. Skin corrosion/ irritation Category 1C Skin Corr. 1C GHS05 Category 2 Skin Irrit. 2 Warning H315 Causes skin irritation. Category 1 Eye Dam. 1 H318 Causes serious eye damage. Serious eye damage/ eye irritation GHS05 Category 2 Eye Irrit. 2 Warning H319 Causes serious eye irritation. Respiratory sensitization Category 1 Category 1A Category 1B Resp. Sens. 1 Resp. Sens. 1A Resp. Sens. 1B H334 May cause allergy or asthma symptoms or breathing difficulties if inhaled. GHS05 Skin sensitization Category 1 Category 1A Category 1B Skin Sens. 1 Skin Sens. 1A Skin Sens. 1B Warning H317 May cause an allergic skin reaction. Germ cell mutagenicity Carcinogenicity Reproductive toxicity Category 1A Muta. 1A H340 May cause genetic defects. (*) Category 1B Muta. 1B Category 2 Muta. 2 Warning H341 Suspected of causing genetic defects. (*) Category 1A Carc. 1A H350 May cause cancer. (*) Category 1B Carc. 1B H350i May cause cancer by inhalation. GHS08 Category 2 Carc. 2 Warning H351 Suspected of causing cancer. (*) (*) state route of exposure if it is conclusively proven that no other routes of exposure cause the hazard Category 1A Category 1B Repr. 1A Repr. 1B Category 2 Repr. 2 Warning GHS08 H360 H360F H360D H360FD H361 H361f H361d H361fd May damage fertility or the unborn child. (*) May damage fertility. (*) May damage the unborn child. (*) May damage fertility. May damage the unborn child. (*) Suspected of damaging fertility or the unborn child. Suspected of damaging fertility. Suspected of damaging the unborn child. Suspected of damaging fertility. Suspected of damaging the unborn child. Additional category for effects Lact. No pictogram No signal word H362 May cause harm to breast-fed children. on or via lactation (*) state route of exposure if it is conclusively proven that no other routes of exposure cause the hazard

12 Classification & Labelling acc. to (EC) 1272/2008 Classification Labelling Hazard class Category codes Pictogram, code Signal word Hazard statements Category 1 STOT SE 1 H370 Causes damage to organs. (*) Specific target organ toxicity single exposure Category 2 STOT SE 2 Warning H371 May cause damage to organs. (*) GHS08 H335 May cause respiratory irritation. Category 3 STOT SE 3 Warning H336 May cause drowsiness or dizziness. Specific target organ toxicity repeated exposure Category 1 STOT RE 1 H372 Category 2 STOT RE 2 Warning H373 GHS08 (*) state route of exposure if it is conclusively proven that no other routes of exposure cause the hazard Causes damage to organs through prolonged or repeated exposure. (*) May cause damage to organs through prolonged or repeated exposure. (*) Aspiration hazard Category 1 Asp. Tox. 1 H304 May be fatal if swallowed and enters airways. GHS08 Acute aquatic hazard Acute 1 Aquatic Acute 1 Warning H400 Very toxic to aquatic life. Chronic 1 Aquatic Chronic 1 Warning H410 Very toxic to aquatic life with long lasting effects. Long-term aquatic hazard Chronic 2 Aquatic Chronic 2 No signal word H411 Toxic to aquatic life with long lasting effects. GHS09 Chronic 3 Aquatic Chronic 3 H412 Harmful to aquatic life with long lasting effects. No pictogram No signal word Chronic 4 Aquatic Chronic 3 H413 May cause long lasting harmful effects to aquatic life. Hazardous for the ozone layer Category 1 Ozone 1 Warning H420 Harms public health and the environment by destroying ozone in the upper atmosphere.