A Multi-locus Genetic Risk Score for Abdominal Aortic Aneurysm

Size: px
Start display at page:

Download "A Multi-locus Genetic Risk Score for Abdominal Aortic Aneurysm"

Transcription

1 A Multi-locus Genetic Risk Score for Abdominal Aortic Aneurysm Zi Ye, 1 MD, Erin Austin, 1,2 PhD, Daniel J Schaid, 2 PhD, Iftikhar J. Kullo, 1 MD Affiliations: 1 Division of Cardiovascular Diseases and the Gonda Vascular Center, Mayo Clinic, Rochester, MN; 2 Division of Health Science Research AHA ATVB MFMER slide-1

2 Disclosure None 2014 MFMER slide-2

3 Background Abdominal aortic aneurysm (AAA): transverse diameter 3.0cm Prevalence: 12.8% in men; 4.1% in women above 65 years old respectively. Prognosis: mortality of 80% associated with aneurysm rupture; rupture determined by size and aneurysm growth rate Treatment: no pharmacological treatment is available to limit disease progression MFMER slide-3

4 Background AAA is a multifactorial disease with a heritable component GWAS reported several common single nucleotide polymorphisms to be associated with AAA 2014 MFMER slide-4

5 Questions remain Identify biomarkers of AAA to improve disease prediction and enable individualized screening? Genetic risk improve prediction of presence of AAA beyond conventional risk factors? Genetic risk predict aneurysm growth? 2014 MFMER slide-5

6 Hypothesis A multi-locus genetic risk score (GRS) based on SNPs of GWAS may improve disease prediction beyond conventional risk factors and associated with aneurysm growth 2014 MFMER slide-6

7 Study design Case control study Study population: participants from Vascular Disease Biorepository. patients referred for noninvasive vascular evaluation in the Mayo Gonda Vascular Center and stress EKG lab, from 2008 to 2013, consent to give blood sample Ascertainment of conventional risk factors and comorbidities: electronic phenotype algorithms Information from institutional EHR Study questionnaire for smoking status 2014 MFMER slide-7

8 Study design Ascertainment of cases and non-cases: AAA: infrarenal abdominal aortic diameter 3 cm or history of aneurysm repair; Non-AAA: without ICD-9 codes of aortic aneurysm Aneurysm growth rate: latest/pre-operation first diameter / time interval (mm/ year) 2014 MFMER slide-8

9 Study design-genotyping Genomic DNA extracted from whole blood samples drawn at the recruitment Performed in Mayo clinic core lab using Illumina infinium Human core Exome Array, Ilumina Human 610 and 660w Quad-v1 (call rates>95%) Candidate SNPs from GWAS catalog and Pubmed MFMER slide-9

10 Study design-grs Z-test to assess whether the risk estimates of SNPs were substantially different from that in the published literature Candidate SNPs from independent loci (linkage disequilibrium=0) GRS calculation Genotype-informed estimation of risk of coronary heart disease based on genome-wide association data linked to the electronic medical record Keyue Ding, Kent R Bailey and Iftikhar J Kullo BMC Cardiovascular disease 2011, 11: MFMER slide-10

11 Statistical methods Logistic regression analysis: presence of AAA as dependent variable Adjustment: 1) age and sex; and 2) additionally for BMI, hypertension, diabetes, dyslipidemia, ASCVD and family history of aortic aneurysm AUC and net reclassification index were estimated to assess whether GRS can improve disease prediction beyond conventional risk factors. Aneurysm growth rate 2014 MFMER slide-11

12 Results 2014 MFMER slide-12

13 Table. Associations of SNPs with presence of AAA Locus Gene SNPs (risk allele) MAF OR (95% CI) 19p13.2 LDLR rs (G) ( ) 12q13.3 LRP1 rs (c) ( ) 9p33.2 DAB2IP rs (A) ( ) 9p21 CDKN2 A-2B In literature In VDB Z test P- MAF value 2x10^ x10^ x10^ rs (T) x10^ p13.3 SORT1 rs (G) ( ) 7.2x1 0^ OR (95% CI) 1.04 ( ) 1.04 ( ) 1.17 ( ) 1.22 ( ) 0.90 ( ) P-value P- value MFMER slide-13

14 Table. Patient characteristics AAA (n=1098) Non-AAA (n=6538) Age, years 74 (8) 67 (11) Men 915 (83) 4039 (62) Body mass index, kg/m (4.9) 29.1 (5.6) *Smoking (ever) 952 (87) 3800 (58) *Hypertension 908 (82) 4203 (64) Type 2 diabetes 342 (25) 1819 (22) *Dyslipidemia 959 (87) 4931 (75) *ASCVD 966 (88) 4552 (70) *Family history of aortic aneurysm 178 (16) 471 (7) *GRS 5.34 (2.74) 4.89 (2.86) Values expressed as mean (SD) or number (%).*P-value < 0.05 for comparisons in cases vs. non-cases adjusted for age and sex. Abbreviations: AAA=abdominal aortic aneurysm; ASCVD=atherosclerotic cardiovascular disease; GRS=genetic risk score MFMER slide-14

15 Age & sex adjusted odds ratio for AAA Covariates OR ( 95% CI) GRS above median 1.37 ( ) FHx of AA 2.49 ( ) ASCVD 2.74 ( ) Type 2 diabetes 1.00 ( ) Dyslipidemia 2.02 ( ) Hypertension 2.43 ( ) Smoker 3.55 ( ) BMI 30kg/m ( ) MFMER slide-15

16 Multivariable regression analysis: odds ratio for presence of AAA Covariates OR ( 95% CI) Age >65 years 1.55 ( ) Male sex 2.98 ( ) GRS above median 1.31 ( ) FHx of AA 2.43 ( ) ASCVD 2.09 ( ) Type 2 diabetes 0.78 ( ) Dyslipidemia 1.32 ( ) Hypertension 1.86 ( ) Smoker 3.35 ( ) BMI 30kg/m ( ) MFMER slide-16

17 Association with AAA size change (N=628) 45% 55% Growth rate median 55% 45% Growth rate < median GRS < median GRS median GRS < median GRS median Linear regression Beta (SE) P-value AAA size baseline 1.29 (0.13) <0.001 GRS median 0.44 (0.20) 0.03 Logistic regression OR (95% CI) P- value AAA size baseline 2.78 ( ) <0.001 GRS median 1.5 ( ) MFMER slide-17

18 Conclusions A multi-locus GRS was associated with presence of AAA and greater aneurysm growth, suggesting genetic predisposition to disease initiation and progression 2014 MFMER slide-18

19 Limitations May not generalized to other population Not non-diseased participants with ultrasound screening GRS built based on additive model that may be an over simplification of the true biological mechanism 2014 MFMER slide-19

20 Questions & Discussion 2014 MFMER slide-20

Improving cardiometabolic health in Major Mental Illness

Improving cardiometabolic health in Major Mental Illness Improving cardiometabolic health in Major Mental Illness Dr. Adrian Heald Consultant in Endocrinology and Diabetes Leighton Hospital, Crewe and Macclesfield Research Fellow, Manchester University Metabolic

More information

EHRs and large scale comparative effectiveness research

EHRs and large scale comparative effectiveness research EHRs and large scale comparative effectiveness research September 16, 2014 Dana C. Crawford, PhD Associate Professor Epidemiology and Biostatistics Institute for Computational Biology Single Nucleotide

More information

EXPANDING THE EVIDENCE BASE IN OUTCOMES RESEARCH: USING LINKED ELECTRONIC MEDICAL RECORDS (EMR) AND CLAIMS DATA

EXPANDING THE EVIDENCE BASE IN OUTCOMES RESEARCH: USING LINKED ELECTRONIC MEDICAL RECORDS (EMR) AND CLAIMS DATA EXPANDING THE EVIDENCE BASE IN OUTCOMES RESEARCH: USING LINKED ELECTRONIC MEDICAL RECORDS (EMR) AND CLAIMS DATA A CASE STUDY EXAMINING RISK FACTORS AND COSTS OF UNCONTROLLED HYPERTENSION ISPOR 2013 WORKSHOP

More information

NGS and complex genetics

NGS and complex genetics NGS and complex genetics Robert Kraaij Genetic Laboratory Department of Internal Medicine r.kraaij@erasmusmc.nl Gene Hunting Rotterdam Study and GWAS Next Generation Sequencing Gene Hunting Mendelian gene

More information

Overview. Total Joint Replacement in the U.S. KP National Total Joint Registry EMR Tools and Outcome Assessment: A Model for Vascular Surgery?

Overview. Total Joint Replacement in the U.S. KP National Total Joint Registry EMR Tools and Outcome Assessment: A Model for Vascular Surgery? KP National Total Joint Registry EMR Tools and Outcome Assessment: A Model for Vascular Surgery? Liz Paxton Director of Surgical Outcomes and Analysis Overview KP Total Joint Replacement Registry Background

More information

Listen to your heart: Good Cardiovascular Health for Life

Listen to your heart: Good Cardiovascular Health for Life Listen to your heart: Good Cardiovascular Health for Life Luis R. Castellanos MD, MPH Assistant Clinical Professor of Medicine University of California San Diego School of Medicine Sulpizio Family Cardiovascular

More information

Logistic Regression (1/24/13)

Logistic Regression (1/24/13) STA63/CBB540: Statistical methods in computational biology Logistic Regression (/24/3) Lecturer: Barbara Engelhardt Scribe: Dinesh Manandhar Introduction Logistic regression is model for regression used

More information

Big Data for Population Health and Personalised Medicine through EMR Linkages

Big Data for Population Health and Personalised Medicine through EMR Linkages Big Data for Population Health and Personalised Medicine through EMR Linkages Zheng-Ming CHEN Professor of Epidemiology Nuffield Dept. of Population Health, University of Oxford Big Data for Health Policy

More information

Predicting The Risk Of Rheumatoid Arthritis

Predicting The Risk Of Rheumatoid Arthritis Predicting The Risk Of Rheumatoid Arthritis Modelling Genetic And Environmental Risk Factors Ian Scott Arthritis Research UK Clinical Research Fellow Declaration Of Interests: No Competing Interests Describe

More information

C-Reactive Protein and Diabetes: proving a negative, for a change?

C-Reactive Protein and Diabetes: proving a negative, for a change? C-Reactive Protein and Diabetes: proving a negative, for a change? Eric Brunner PhD FFPH Reader in Epidemiology and Public Health MRC Centre for Causal Analyses in Translational Epidemiology 2 March 2009

More information

PRACTICE PROBLEMS FOR BIOSTATISTICS

PRACTICE PROBLEMS FOR BIOSTATISTICS PRACTICE PROBLEMS FOR BIOSTATISTICS BIOSTATISTICS DESCRIBING DATA, THE NORMAL DISTRIBUTION 1. The duration of time from first exposure to HIV infection to AIDS diagnosis is called the incubation period.

More information

Main Effect of Screening for Coronary Artery Disease Using CT

Main Effect of Screening for Coronary Artery Disease Using CT Main Effect of Screening for Coronary Artery Disease Using CT Angiography on Mortality and Cardiac Events in High risk Patients with Diabetes: The FACTOR-64 Randomized Clinical Trial Joseph B. Muhlestein,

More information

School of Nursing. Presented by Yvette Conley, PhD

School of Nursing. Presented by Yvette Conley, PhD Presented by Yvette Conley, PhD What we will cover during this webcast: Briefly discuss the approaches introduced in the paper: Genome Sequencing Genome Wide Association Studies Epigenomics Gene Expression

More information

Impact of Massachusetts Health Care Reform on Racial, Ethnic and Socioeconomic Disparities in Cardiovascular Care

Impact of Massachusetts Health Care Reform on Racial, Ethnic and Socioeconomic Disparities in Cardiovascular Care Impact of Massachusetts Health Care Reform on Racial, Ethnic and Socioeconomic Disparities in Cardiovascular Care Michelle A. Albert MD MPH Treacy S. Silbaugh B.S, John Z. Ayanian MD MPP, Ann Lovett RN

More information

DISCLOSURES RISK ASSESSMENT. Stroke and Heart Disease -Is there a Link Beyond Risk Factors? Daniel Lackland, MD

DISCLOSURES RISK ASSESSMENT. Stroke and Heart Disease -Is there a Link Beyond Risk Factors? Daniel Lackland, MD STROKE AND HEART DISEASE IS THERE A LINK BEYOND RISK FACTORS? D AN IE L T. L AC K L AN D DISCLOSURES Member of NHLBI Risk Assessment Workgroup RISK ASSESSMENT Count major risk factors For patients with

More information

GENETIC DATA ANALYSIS

GENETIC DATA ANALYSIS GENETIC DATA ANALYSIS 1 Genetic Data: Future of Personalized Healthcare To achieve personalization in Healthcare, there is a need for more advancements in the field of Genomics. The human genome is made

More information

Epigenetic variation and complex disease risk

Epigenetic variation and complex disease risk Epigenetic variation and complex disease risk Caroline Relton Institute of Human Genetics Newcastle University ALSPAC Research Symposium 2 & 3 March 2009 Missing heritability Even when dozens of genes

More information

Results of streamlined regional ambulance transport and subsequent treatment of acute abdominal aortic aneurysm

Results of streamlined regional ambulance transport and subsequent treatment of acute abdominal aortic aneurysm CHAPTER 6 Results of streamlined regional ambulance transport and subsequent treatment of acute abdominal aortic aneurysm JW Haveman, A Karliczek, ELG Verhoeven, IFJ Tielliu, R de Vos, JH Zwaveling, JJAM

More information

Heritability: Twin Studies. Twin studies are often used to assess genetic effects on variation in a trait

Heritability: Twin Studies. Twin studies are often used to assess genetic effects on variation in a trait TWINS AND GENETICS TWINS Heritability: Twin Studies Twin studies are often used to assess genetic effects on variation in a trait Comparing MZ/DZ twins can give evidence for genetic and/or environmental

More information

Electronic Medical Records and Genomics: Possibilities, Realities, Ethical Issues to Consider

Electronic Medical Records and Genomics: Possibilities, Realities, Ethical Issues to Consider Electronic Medical Records and Genomics: Possibilities, Realities, Ethical Issues to Consider Daniel Masys, M.D. Affiliate Professor Biomedical and Health Informatics University of Washington, Seattle

More information

The Cross-Sectional Study:

The Cross-Sectional Study: The Cross-Sectional Study: Investigating Prevalence and Association Ronald A. Thisted Departments of Health Studies and Statistics The University of Chicago CRTP Track I Seminar, Autumn, 2006 Lecture Objectives

More information

FACILITATOR/MENTOR GUIDE

FACILITATOR/MENTOR GUIDE FACILITATOR/MENTOR GUIDE Descriptive analysis variables table shells hypotheses Measures of association methods design justify analytic assess calculate analysis problem stratify confounding statistical

More information

Abdominal Aortic Aneurysm (AAA) General Information. Patient information Leaflet

Abdominal Aortic Aneurysm (AAA) General Information. Patient information Leaflet Abdominal Aortic Aneurysm (AAA) General Information Patient information Leaflet 1 st July 2016 WHAT IS THE AORTA? The aorta is the largest artery (blood vessel) in the body. It carries blood from the heart

More information

Psoriasis Co-morbidities: Changing Clinical Practice. Theresa Schroeder Devere, MD Assistant Professor, OHSU Dermatology. Psoriatic Arthritis

Psoriasis Co-morbidities: Changing Clinical Practice. Theresa Schroeder Devere, MD Assistant Professor, OHSU Dermatology. Psoriatic Arthritis Psoriasis Co-morbidities: Changing Clinical Practice Theresa Schroeder Devere, MD Assistant Professor, OHSU Dermatology Psoriatic Arthritis Psoriatic Arthritis! 11-31% of patients with psoriasis have psoriatic

More information

NHS Diabetes Prevention Programme (NHS DPP) Non-diabetic hyperglycaemia. Produced by: National Cardiovascular Intelligence Network (NCVIN)

NHS Diabetes Prevention Programme (NHS DPP) Non-diabetic hyperglycaemia. Produced by: National Cardiovascular Intelligence Network (NCVIN) NHS Diabetes Prevention Programme (NHS DPP) Non-diabetic hyperglycaemia Produced by: National Cardiovascular Intelligence Network (NCVIN) Date: August 2015 About Public Health England Public Health England

More information

Potentials for EHR Phenotyping in SJS/TEN

Potentials for EHR Phenotyping in SJS/TEN Potentials for EHR Phenotyping in SJS/TEN Josh Denny, MD, MS josh.denny@vanderbilt.edu Vanderbilt University, Nashville, Tennessee, USA 3/3/2015 emerge goals To perform GWAS using EMR-derived phenotypes

More information

Genetics of Rheumatoid Arthritis Markey Lecture Series

Genetics of Rheumatoid Arthritis Markey Lecture Series Genetics of Rheumatoid Arthritis Markey Lecture Series Al Kim akim@dom.wustl.edu 2012.09.06 Overview of Rheumatoid Arthritis Rheumatoid Arthritis (RA) Autoimmune disease primarily targeting the synovium

More information

Underwriting Critical Illness Insurance: A model for coronary heart disease and stroke

Underwriting Critical Illness Insurance: A model for coronary heart disease and stroke Underwriting Critical Illness Insurance: A model for coronary heart disease and stroke Presented to the 6th International Congress on Insurance: Mathematics and Economics. July 2002. Lisbon, Portugal.

More information

Traditional View of Diabetes. Are children with type 1 diabetes obese: What can we do? 8/9/2012. Change in Traditional View of Diabetes

Traditional View of Diabetes. Are children with type 1 diabetes obese: What can we do? 8/9/2012. Change in Traditional View of Diabetes Are children with type 1 diabetes obese: What can we do? Traditional View of Diabetes Type 1 Diabetes ( T1DM) Onset Juvenile Lean Type 2 Diabetes ( T2DM) Onset Adult Obese QI Project Indrajit Majumdar

More information

Prognostic impact of uric acid in patients with stable coronary artery disease

Prognostic impact of uric acid in patients with stable coronary artery disease Prognostic impact of uric acid in patients with stable coronary artery disease Gjin Ndrepepa, Siegmund Braun, Martin Hadamitzky, Massimiliano Fusaro, Hans-Ullrich Haase, Kathrin A. Birkmeier, Albert Schomig,

More information

GENETICS AND HEALTH INSURANCE

GENETICS AND HEALTH INSURANCE GENETICS AND HEALTH INSURANCE Angus Macdonald Department of Actuarial Mathematics and Statistics and the Maxwell Institute for Mathematical Sciences Heriot-Watt University, Edinburgh www.maxwell.ac.uk

More information

General and Abdominal Adiposity and Risk of Death in Europe

General and Abdominal Adiposity and Risk of Death in Europe Deutsches Institut für Ernährungsforschung Potsdam-Rehbrücke General and Abdominal Adiposity and Risk of Death in Europe Tobias Pischon Department of Epidemiology German Institute of Human Nutrition Potsdam-Rehbruecke

More information

Major US Genomic Medicine Programs: NHGRI s Electronic Medical Records and Genomics (emerge) Network

Major US Genomic Medicine Programs: NHGRI s Electronic Medical Records and Genomics (emerge) Network Major US Genomic Medicine Programs: NHGRI s Electronic Medical Records and Genomics (emerge) Network Dan Roden Member, National Advisory Council For Human Genome Research Genomic Medicine Working Group

More information

Online Supplement to Polygenic Influence on Educational Attainment. Genotyping was conducted with the Illumina HumanOmni1-Quad v1 platform using

Online Supplement to Polygenic Influence on Educational Attainment. Genotyping was conducted with the Illumina HumanOmni1-Quad v1 platform using Online Supplement to Polygenic Influence on Educational Attainment Construction of Polygenic Score for Educational Attainment Genotyping was conducted with the Illumina HumanOmni1-Quad v1 platform using

More information

Are differences in methylation in cord blood DNA associated with prenatal exposure to alcohol?

Are differences in methylation in cord blood DNA associated with prenatal exposure to alcohol? Are differences in methylation in cord blood DNA associated with prenatal exposure to alcohol? Luisa Zuccolo l.zuccolo@bristol.ac.uk MRC IEU, School of Social and Community Medicine Outline Background

More information

Sponsor. Novartis Generic Drug Name. Vildagliptin. Therapeutic Area of Trial. Type 2 diabetes. Approved Indication. Investigational.

Sponsor. Novartis Generic Drug Name. Vildagliptin. Therapeutic Area of Trial. Type 2 diabetes. Approved Indication. Investigational. Clinical Trial Results Database Page 1 Sponsor Novartis Generic Drug Name Vildagliptin Therapeutic Area of Trial Type 2 diabetes Approved Indication Investigational Study Number CLAF237A2386 Title A single-center,

More information

Preventive Services for Pregnancy SERVICE WHAT IS COVERED INTERVALS OF COVERAGE Anemia Screening Screening Annual screening for pregnant women

Preventive Services for Pregnancy SERVICE WHAT IS COVERED INTERVALS OF COVERAGE Anemia Screening Screening Annual screening for pregnant women Preventive Services for Pregnancy SERVICE WHAT IS COVERED INTERVALS OF COVERAGE Anemia Annual screening for pregnant women Bacteriuria For pregnant women at 12-16 weeks gestation or first prenatal visit

More information

Clinical Research on Lifestyle Interventions to Treat Obesity and Asthma in Primary Care Jun Ma, M.D., Ph.D.

Clinical Research on Lifestyle Interventions to Treat Obesity and Asthma in Primary Care Jun Ma, M.D., Ph.D. Clinical Research on Lifestyle Interventions to Treat Obesity and Asthma in Primary Care Jun Ma, M.D., Ph.D. Associate Investigator Palo Alto Medical Foundation Research Institute Consulting Assistant

More information

Genetics for preventative cardiology. Objectives HEART DISEASE COMES IN MANY FORMS!

Genetics for preventative cardiology. Objectives HEART DISEASE COMES IN MANY FORMS! Genetics for preventative cardiology Robert Nussbaum, MD Chief of Genomic Medicine, UCSF Medical Center; Co-Director, Program in Cardiovascular Genetics, UCSF Heart and Vascular Center Julianne Wojciak,

More information

Social inequalities in all cause and cause specific mortality in a country of the African region

Social inequalities in all cause and cause specific mortality in a country of the African region Social inequalities in all cause and cause specific mortality in a country of the African region Silvia STRINGHINI 1, Valentin Rousson 1, Bharathi Viswanathan 2, Jude Gedeon 2, Fred Paccaud 1, Pascal Bovet

More information

Refugees with diabetes mellitus have higher prevalence of latent tuberculosis infection

Refugees with diabetes mellitus have higher prevalence of latent tuberculosis infection Refugees with diabetes mellitus have higher prevalence of latent tuberculosis infection Matthew Magee Division of Epidemiology and Biostatistics School of Public Health, Georgia State University Saturday,

More information

Komorbide brystkræftpatienter kan de tåle behandling? Et registerstudie baseret på Danish Breast Cancer Cooperative Group

Komorbide brystkræftpatienter kan de tåle behandling? Et registerstudie baseret på Danish Breast Cancer Cooperative Group Komorbide brystkræftpatienter kan de tåle behandling? Et registerstudie baseret på Danish Breast Cancer Cooperative Group Lotte Holm Land MD, ph.d. Onkologisk Afd. R. OUH Kræft og komorbiditet - alle skal

More information

Metabolic Syndrome Overview: Easy Living, Bitter Harvest. Sabrina Gill MD MPH FRCPC Caroline Stigant MD FRCPC BC Nephrology Days, October 2007

Metabolic Syndrome Overview: Easy Living, Bitter Harvest. Sabrina Gill MD MPH FRCPC Caroline Stigant MD FRCPC BC Nephrology Days, October 2007 Metabolic Syndrome Overview: Easy Living, Bitter Harvest Sabrina Gill MD MPH FRCPC Caroline Stigant MD FRCPC BC Nephrology Days, October 2007 Evolution of Metabolic Syndrome 1923: Kylin describes clustering

More information

GENETICS AND INSURANCE: QUANTIFYING THE IMPACT OF GENETIC INFORMATION

GENETICS AND INSURANCE: QUANTIFYING THE IMPACT OF GENETIC INFORMATION GENETICS AND INSURANCE: QUANTIFYING THE IMPACT OF GENETIC INFORMATION Angus Macdonald Department of Actuarial Mathematics and Statistics and the Maxwell Institute for Mathematical Sciences Heriot-Watt

More information

Hormones and cardiovascular disease, what the Danish Nurse Cohort learned us

Hormones and cardiovascular disease, what the Danish Nurse Cohort learned us Hormones and cardiovascular disease, what the Danish Nurse Cohort learned us Ellen Løkkegaard, Clinical Associate Professor, Ph.d. Dept. Obstetrics and Gynecology. Hillerød Hospital, University of Copenhagen

More information

Summary ID# 13614. Clinical Study Summary: Study F3Z-JE-PV06

Summary ID# 13614. Clinical Study Summary: Study F3Z-JE-PV06 CT Registry ID# Page 1 Summary ID# 13614 Clinical Study Summary: Study F3Z-JE-PV06 INSIGHTS; INSulin-changing study Intending to Gain patients insights into insulin treatment with patient-reported Health

More information

How To Determine Pad

How To Determine Pad Process Representation #1 : The PAD algorithm as a sequential flow thru all sections An exploded version of the above scoped section flow is shown below. Notes: The flow presupposes existing services (

More information

A Markov model for long-term cost-effectiveness modelling of screening for abdominal aortic aneurysms

A Markov model for long-term cost-effectiveness modelling of screening for abdominal aortic aneurysms A Markov model for long-term cost-effectiveness modelling of screening for abdominal aortic aneurysms Version 2 July 2006 Lois Kim, MRC Biostatistics Unit, Institute of Public Health, Robinson Way, Cambridge

More information

Core Facility Genomics

Core Facility Genomics Core Facility Genomics versatile genome or transcriptome analyses based on quantifiable highthroughput data ascertainment 1 Topics Collaboration with Harald Binder and Clemens Kreutz Project: Microarray

More information

Mortality Assessment Technology: A New Tool for Life Insurance Underwriting

Mortality Assessment Technology: A New Tool for Life Insurance Underwriting Mortality Assessment Technology: A New Tool for Life Insurance Underwriting Guizhou Hu, MD, PhD BioSignia, Inc, Durham, North Carolina Abstract The ability to more accurately predict chronic disease morbidity

More information

METABOLIC SYNDROME IN A CORRECTIONS POPULATION TREATED WITH ANTIPSYCHOTICS

METABOLIC SYNDROME IN A CORRECTIONS POPULATION TREATED WITH ANTIPSYCHOTICS METABOLIC SYNDROME IN A CORRECTIONS POPULATION TREATED WITH ANTIPSYCHOTICS Andrew M. Cislo, PhD Megan J. Ehret, PharmD, MS, BCPP Robert L. Trestman, MD, PhD Kirsten Shea, MBA www.uchc.edu Background Metabolic

More information

06 Validation of risk prediction model

06 Validation of risk prediction model HA Territory-wide PCI Audit 2003-06 06 Validation of risk prediction model PCI Audit Working Group Central Committee (Cardiac Services) HA Convention 2007 Background Participants: All HA hospitals via

More information

The Prevalence and Determinants of Undiagnosed and Diagnosed Type 2 Diabetes in Middle-Aged Irish Adults

The Prevalence and Determinants of Undiagnosed and Diagnosed Type 2 Diabetes in Middle-Aged Irish Adults The Prevalence and Determinants of Undiagnosed and Diagnosed Type 2 Diabetes in Middle-Aged Irish Adults Seán R. Millar, Jennifer M. O Connor, Claire M. Buckley, Patricia M. Kearney, Ivan J. Perry Email:

More information

Validation and Replication

Validation and Replication Validation and Replication Overview Definitions of validation and replication Difficulties and limitations Working examples from our group and others Why? False positive results still occur. even after

More information

FULL COVERAGE FOR PREVENTIVE MEDICATIONS AFTER MYOCARDIAL INFARCTION IMPACT ON RACIAL AND ETHNIC DISPARITIES

FULL COVERAGE FOR PREVENTIVE MEDICATIONS AFTER MYOCARDIAL INFARCTION IMPACT ON RACIAL AND ETHNIC DISPARITIES FULL COVERAGE FOR PREVENTIVE MEDICATIONS AFTER MYOCARDIAL INFARCTION IMPACT ON RACIAL AND ETHNIC DISPARITIES Niteesh K. Choudhry, MD, PhD Harvard Medical School Division of Pharmacoepidemiology and Pharmacoeconomics

More information

Low diabetes numeracy predicts worse glycemic control

Low diabetes numeracy predicts worse glycemic control Low diabetes numeracy predicts worse glycemic control Kerri L. Cavanaugh, MD MHS, Kenneth A. Wallston, PhD, Tebeb Gebretsadik, MPH, Ayumi Shintani, PhD, MPH, Darren DeWalt, MD MPH, Michael Pignone, MD

More information

Genomics and Health Data Standards: Lessons from the Past and Present for a Genome-enabled Future

Genomics and Health Data Standards: Lessons from the Past and Present for a Genome-enabled Future Genomics and Health Data Standards: Lessons from the Past and Present for a Genome-enabled Future Daniel Masys, MD Professor and Chair Department of Biomedical Informatics Professor of Medicine Vanderbilt

More information

Incorporating Research Into Sight (IRIS) Essentia Rural Health Institute Marshfield Clinic Penn State University

Incorporating Research Into Sight (IRIS) Essentia Rural Health Institute Marshfield Clinic Penn State University Incorporating Research Into Sight (IRIS) Essentia Rural Health Institute Marshfield Clinic Penn State University Aim 1. Develop and validate electronic algorithms for ophthalmic conditions and efficacy

More information

Summary and conclusions. Chapter 8. Summary and conclusions

Summary and conclusions. Chapter 8. Summary and conclusions Summary and conclusions Chapter 8 Summary and conclusions 153 Chapter 8 154 Summary and conclusions Summary This thesis describes an experimental study in healthy MZ and same-sex DZ twins and siblings

More information

The Functional but not Nonfunctional LILRA3 Contributes to Sex Bias in Susceptibility and Severity of ACPA-Positive Rheumatoid Arthritis

The Functional but not Nonfunctional LILRA3 Contributes to Sex Bias in Susceptibility and Severity of ACPA-Positive Rheumatoid Arthritis The Functional but not Nonfunctional LILRA3 Contributes to Sex Bias in Susceptibility and Severity of ACPA-Positive Rheumatoid Arthritis Yan Du Peking University People s Hospital 100044 Beijing CHINA

More information

Technical Issues in Aggregating and Analyzing Data from Heterogeneous EHR Systems

Technical Issues in Aggregating and Analyzing Data from Heterogeneous EHR Systems Technical Issues in Aggregating and Analyzing Data from Heterogeneous EHR Systems Josh Denny, MD, MS josh.denny@vanderbilt.edu Vanderbilt University, Nashville, Tennessee, USA 2/12/2015 EHR data are dense

More information

Principles of Hypothesis Testing for Public Health

Principles of Hypothesis Testing for Public Health Principles of Hypothesis Testing for Public Health Laura Lee Johnson, Ph.D. Statistician National Center for Complementary and Alternative Medicine johnslau@mail.nih.gov Fall 2011 Answers to Questions

More information

Prevalence of alcohol consumption among Rheumatoid Arthritis patients on Methotrexate and impact on liver function tests

Prevalence of alcohol consumption among Rheumatoid Arthritis patients on Methotrexate and impact on liver function tests Prevalence of alcohol consumption among Rheumatoid Arthritis patients on Methotrexate and impact on liver function tests Christine Iannaccone, MPH, Michelle Frits, Jing Cui, PhD, Michael Weinblatt MD,

More information

PARTICIPANT INFORMATION

PARTICIPANT INFORMATION PARTICIPANT INFORMATION IMPERIAL POPULATION BIORESOURCE TISSUE BANK (PART OF NIHR BIORESOURCE) In the UK around 20 million people are said to be living with a long-term condition such as diabetes or heart

More information

Exploratory data: COPD and blood eosinophils. David Price: 9.23-9.35am

Exploratory data: COPD and blood eosinophils. David Price: 9.23-9.35am Exploratory data: COPD and blood eosinophils David Price: 9.23-9.35am Blood Eosinophilia in COPD The reliability and utility of blood eosinophils as a marker of disease burden, healthcare resource utilisation

More information

Multivariate Logistic Regression

Multivariate Logistic Regression 1 Multivariate Logistic Regression As in univariate logistic regression, let π(x) represent the probability of an event that depends on p covariates or independent variables. Then, using an inv.logit formulation

More information

on behalf of the AUGMENT-HF Investigators

on behalf of the AUGMENT-HF Investigators One Year Follow-Up Results from AUGMENT-HF: A Multicenter Randomized Controlled Clinical Trial of the Efficacy of Left Ventricular Augmentation with Algisyl-LVR in the Treatment of Heart Failure* Douglas

More information

Appendix: Description of the DIETRON model

Appendix: Description of the DIETRON model Appendix: Description of the DIETRON model Much of the description of the DIETRON model that appears in this appendix is taken from an earlier publication outlining the development of the model (Scarborough

More information

STROKE April 2011 Dr Amer Jafar A delay in recognizing early warning signs (WS) and risk factors (RF) of ischemic stroke causes a delay in treatment Evaluated: knowledge of RF and WS and the impact of

More information

Driving molecular pharmacology research utilizing EHRs and enhanced analytics:

Driving molecular pharmacology research utilizing EHRs and enhanced analytics: Driving molecular pharmacology research utilizing EHRs and enhanced analytics: An application of metformin in breast cancer and type II diabetes mellitus. Academic Health Center Informatics Grand Rounds,

More information

TYPE 2 DIABETES MELLITUS: NEW HOPE FOR PREVENTION. Robert Dobbins, M.D. Ph.D.

TYPE 2 DIABETES MELLITUS: NEW HOPE FOR PREVENTION. Robert Dobbins, M.D. Ph.D. TYPE 2 DIABETES MELLITUS: NEW HOPE FOR PREVENTION Robert Dobbins, M.D. Ph.D. Learning Objectives Recognize current trends in the prevalence of type 2 diabetes. Learn differences between type 1 and type

More information

HLA-Cw*0602 associates with a twofold higher prevalence. of positive streptococcal throat swab at the onset of

HLA-Cw*0602 associates with a twofold higher prevalence. of positive streptococcal throat swab at the onset of 1 HLA-Cw*0602 associates with a twofold higher prevalence of positive streptococcal throat swab at the onset of psoriasis: a case control study Lotus Mallbris, MD, PhD, Katarina Wolk, MD, Fabio Sánchez

More information

Diabetes Prevention in Latinos

Diabetes Prevention in Latinos Diabetes Prevention in Latinos Matthew O Brien, MD, MSc Assistant Professor of Medicine and Public Health Northwestern Feinberg School of Medicine Institute for Public Health and Medicine October 17, 2013

More information

CARDIOVASCULAR PROBLEMS IN SURVIVORS OF CHILDHOOD CANCER AND THEIR SIBLINGS

CARDIOVASCULAR PROBLEMS IN SURVIVORS OF CHILDHOOD CANCER AND THEIR SIBLINGS Swiss Childhood Cancer Registry (SCCR) CARDIOVASCULAR PROBLEMS IN SURVIVORS OF CHILDHOOD CANCER AND THEIR SIBLINGS Julien Caccia, Corina S. Rueegg, Eva-Maria Hau, Nicolas X. von der Weid, Gisela Michel,

More information

Systolic Blood Pressure Intervention Trial (SPRINT) Principal Results

Systolic Blood Pressure Intervention Trial (SPRINT) Principal Results Systolic Blood Pressure Intervention Trial (SPRINT) Principal Results Paul K. Whelton, MB, MD, MSc Chair, SPRINT Steering Committee Tulane University School of Public Health and Tropical Medicine, and

More information

FACTORS ASSOCIATED WITH HEALTHCARE COSTS AMONG ELDERLY PATIENTS WITH DIABETIC NEUROPATHY

FACTORS ASSOCIATED WITH HEALTHCARE COSTS AMONG ELDERLY PATIENTS WITH DIABETIC NEUROPATHY FACTORS ASSOCIATED WITH HEALTHCARE COSTS AMONG ELDERLY PATIENTS WITH DIABETIC NEUROPATHY Luke Boulanger, MA, MBA 1, Yang Zhao, PhD 2, Yanjun Bao, PhD 1, Cassie Cai, MS, MSPH 1, Wenyu Ye, PhD 2, Mason W

More information

Factors for success in big data science

Factors for success in big data science Factors for success in big data science Damjan Vukcevic Data Science Murdoch Childrens Research Institute 16 October 2014 Big Data Reading Group (Department of Mathematics & Statistics, University of Melbourne)

More information

Combining Data from Different Genotyping Platforms. Gonçalo Abecasis Center for Statistical Genetics University of Michigan

Combining Data from Different Genotyping Platforms. Gonçalo Abecasis Center for Statistical Genetics University of Michigan Combining Data from Different Genotyping Platforms Gonçalo Abecasis Center for Statistical Genetics University of Michigan The Challenge Detecting small effects requires very large sample sizes Combined

More information

Presentation by: Ahmad Alsahaf. Research collaborator at the Hydroinformatics lab - Politecnico di Milano MSc in Automation and Control Engineering

Presentation by: Ahmad Alsahaf. Research collaborator at the Hydroinformatics lab - Politecnico di Milano MSc in Automation and Control Engineering Johann Bernoulli Institute for Mathematics and Computer Science, University of Groningen 9-October 2015 Presentation by: Ahmad Alsahaf Research collaborator at the Hydroinformatics lab - Politecnico di

More information

Atherosclerosis of the aorta. Artur Evangelista

Atherosclerosis of the aorta. Artur Evangelista Atherosclerosis of the aorta Artur Evangelista Atherosclerosis of the aorta Diagnosis Classification Prevalence Risk factors Marker of generalized atherosclerosis Risk of embolism Therapy Diagnosis Atherosclerosis

More information

GAW 15 Problem 3: Simulated Rheumatoid Arthritis Data Full Model and Simulation Parameters

GAW 15 Problem 3: Simulated Rheumatoid Arthritis Data Full Model and Simulation Parameters GAW 15 Problem 3: Simulated Rheumatoid Arthritis Data Full Model and Simulation Parameters Michael B Miller , Michael Li , Gregg Lind , Soon-Young

More information

Addressing Racial/Ethnic Disparities in Hypertensive Health Center Patients

Addressing Racial/Ethnic Disparities in Hypertensive Health Center Patients Addressing Racial/Ethnic Disparities in Hypertensive Health Center Patients Academy Health June 11, 2011 Quyen Ngo Metzger, MD, MPH Data Branch Chief, Office of Quality and Data U.S. Department of Health

More information

Atrial Fibrillation: A Different Perspective. Michael Heffernan MD PhD FRCPC FACC Staff Cardiologist Oakville Hospital

Atrial Fibrillation: A Different Perspective. Michael Heffernan MD PhD FRCPC FACC Staff Cardiologist Oakville Hospital Atrial Fibrillation: A Different Perspective Michael Heffernan MD PhD FRCPC FACC Staff Cardiologist Oakville Hospital Faculty/Presenter Disclosure Faculty: Dr. Michael Heffernan Relationships with commercial

More information

This clinical study synopsis is provided in line with Boehringer Ingelheim s Policy on Transparency and Publication of Clinical Study Data.

This clinical study synopsis is provided in line with Boehringer Ingelheim s Policy on Transparency and Publication of Clinical Study Data. abcd Clinical Study for Public Disclosure This clinical study synopsis is provided in line with s Policy on Transparency and Publication of Clinical Study Data. The synopsis which is part of the clinical

More information

Renal cell carcinoma and body composition:

Renal cell carcinoma and body composition: Renal cell carcinoma and body composition: Results from a case-control control study Ryan P. Theis, MPH Department of Epidemiology and Biostatistics College of Public Health and Health Professions University

More information

The Scottish Health Survey

The Scottish Health Survey The Scottish Health Survey The Glasgow Effect Topic Report A National Statistics Publication for Scotland The Scottish Health Survey The Glasgow Effect Topic Report The Scottish Government, Edinburgh

More information

Estimating the Completeness of Physician Billing Claims for Diabetes Case Ascertainment

Estimating the Completeness of Physician Billing Claims for Diabetes Case Ascertainment Estimating the Completeness of Physician Billing Claims for Diabetes Case Ascertainment Lisa M. Lix, Xue Yao, George Kephart, Khokan Sikdar, Hude Quan, J. Paul Kuwornu, Wilfrid Kouokam, Mark Smith IHDLN

More information

Importance of Statistics in creating high dimensional data

Importance of Statistics in creating high dimensional data Importance of Statistics in creating high dimensional data Hemant K. Tiwari, PhD Section on Statistical Genetics Department of Biostatistics University of Alabama at Birmingham History of Genomic Data

More information

Using EHRs for Heart Failure Therapy Recommendation Using Multidimensional Patient Similarity Analytics

Using EHRs for Heart Failure Therapy Recommendation Using Multidimensional Patient Similarity Analytics Digital Healthcare Empowering Europeans R. Cornet et al. (Eds.) 2015 European Federation for Medical Informatics (EFMI). This article is published online with Open Access by IOS Press and distributed under

More information

Use of the Chi-Square Statistic. Marie Diener-West, PhD Johns Hopkins University

Use of the Chi-Square Statistic. Marie Diener-West, PhD Johns Hopkins University This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike License. Your use of this material constitutes acceptance of that license and the conditions of use of materials on this

More information

Building risk prediction models - with a focus on Genome-Wide Association Studies. Charles Kooperberg

Building risk prediction models - with a focus on Genome-Wide Association Studies. Charles Kooperberg Building risk prediction models - with a focus on Genome-Wide Association Studies Risk prediction models Based on data: (D i, X i1,..., X ip ) i = 1,..., n we like to fit a model P(D = 1 X 1,..., X p )

More information

R.P. Zecchin*, J. Baihn, Y.Y. Chai, J. Hungerford, G. Lindsay, M. Owen, J. Thelander, D.L. Ross, C. Chow, A.R. Denniss. Westmead Hospital, Sydney,

R.P. Zecchin*, J. Baihn, Y.Y. Chai, J. Hungerford, G. Lindsay, M. Owen, J. Thelander, D.L. Ross, C. Chow, A.R. Denniss. Westmead Hospital, Sydney, R.P. Zecchin*, J. Baihn, Y.Y. Chai, J. Hungerford, G. Lindsay, M. Owen, J. Thelander, D.L. Ross, C. Chow, A.R. Denniss. Westmead Hospital, Sydney, Australia Cardiac rehabilitation is an effective and safe

More information

Cardiac Rehabilitation The Best Medicine for Your CAD Patients. James A. Stone

Cardiac Rehabilitation The Best Medicine for Your CAD Patients. James A. Stone James A. Stone BPHE, BA, MSc, MD, PhD, FRCPC, FAACVPR, FACC Clinical Professor of Medicine, University of Calgary Total Cardiology, Calgary Acknowledgements and Disclosures Acknowledgements Jacques Genest

More information

Conveners: S. Bruno, C.M. Mastroianni

Conveners: S. Bruno, C.M. Mastroianni SESSIONE 2 Oral communications based on selected abstracts Conveners: S. Bruno, C.M. Mastroianni PNPLA3 variant is an independent predictor of severe steatosis in patients with chronic hepatitis C and

More information

Cohort Studies. Sukon Kanchanaraksa, PhD Johns Hopkins University

Cohort Studies. Sukon Kanchanaraksa, PhD Johns Hopkins University This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike License. Your use of this material constitutes acceptance of that license and the conditions of use of materials on this

More information

Investigating the genetic basis for intelligence

Investigating the genetic basis for intelligence Investigating the genetic basis for intelligence Steve Hsu University of Oregon and BGI www.cog-genomics.org Outline: a multidisciplinary subject 1. What is intelligence? Psychometrics 2. g and GWAS: a

More information

MANAGEMENT OF LIPID DISORDERS: IMPLICATIONS OF THE NEW GUIDELINES

MANAGEMENT OF LIPID DISORDERS: IMPLICATIONS OF THE NEW GUIDELINES MANAGEMENT OF LIPID DISORDERS: IMPLICATIONS OF THE NEW GUIDELINES Robert B. Baron MD MS Professor and Associate Dean UCSF School of Medicine Declaration of full disclosure: No conflict of interest EXPLAINING

More information

Research Article Cardiovascular Risk in Psoriasis: A Population-Based Analysis with Assessment of the Framingham Risk Score

Research Article Cardiovascular Risk in Psoriasis: A Population-Based Analysis with Assessment of the Framingham Risk Score Scientifica Volume 2013, Article ID 371569, 4 pages http://dx.doi.org/10.1155/2013/371569 Research Article Cardiovascular Risk in Psoriasis: A Population-Based Analysis with Assessment of the Framingham

More information

The M.U.R.D.O.C.K. Study

The M.U.R.D.O.C.K. Study 1 The M.U.R.D.O.C.K. Study Measurement to Understand Reclassification of Disease Of Cabarrus/Kannapolis Jessica Tenenbaum, PhD and many, many others 2 MURDOCK Study Measurement to Understand the Reclassification

More information

The birth of the population-based cohort studies in preventive medicine From Framingham to Värmland

The birth of the population-based cohort studies in preventive medicine From Framingham to Värmland EpiScania Symposium Medicon Village, Lund 2 nd September 2015 The birth of the population-based cohort studies in preventive medicine From Framingham to Värmland Peter M Nilsson, MD, PhD Department of

More information