Program. Rengül Atalay & A. Elif Erson-Bensan. Prof. Dr. Ahmet Acar, METU Rector. Nerin Özören, MBD President

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1 Program 27 November, Friday :30-12:00 Arrival and registration 9:00-9:30 KKM, Salon A Welcome Rengül Atalay & A. Elif Erson-Bensan Prof. Dr. Ahmet Acar, METU Rector Nerin Özören, MBD President 9:30-10:30 Plenary Lecture: Regulation of transcription and invasion by EGF family growth factors Yosef Yarden, Weizmann Institute of Science, Department of Biological Regulation, Rehovot, Israel Chair: Nesrin Özeren, Boğaziçi University, Istanbul, 10:30-11:00 Coffee Break + Poster 11:00-11:40 Session 1: Gene Regulation/Signal Transduction Chair: Uygar Tazebay, GTU, Kocali, Keynote lecture: How progesterone promotes breast carcinogenesis Cathrin Brisken EPFL SV ISREC UPBRI, Lausanne, Switzerland 11:40-12:05 IKKe promotes intestinal tumorigenesis via establishing a proinflammatory microenvironment Serkan Göktuna Bilkent University, Molecular Biology and Genetics, Ankara, 12:05-12:30 mir-644a is a Novel Tumor Suppressor Coregulating p53-independent Cell Survival, EMT and Drug Resistance In Breast Cancer Umar Raza, Özge Saatci, Stefan Uhlmann, Erol Eyüpoğlu, Suhail Akhtar Ansari, Emre Yurdusev, Merve Mutlu, Pelin Gülizar Ersan, Stefan Wiemann and Özgür Şahin Bilkent University, Ankara,

2 12:30-14:00 Lunch Break +Poster 14:00-14:40 Session 2: Cell Biology Chair: Esra Çağavi, Medipol University, Istanbul, : Circadian Clock and Cancer Nuri Öztürk, Gebze Institute of Technology, Molecular Biology and Genetics, Kocaeli, 14:40-15:05 Coiled-coil domain-containing protein 124 (Ccdc124) is a centrosome and midbody protein involved in cytokinetic abscission Uygar H. Tazebay, Pelin Telkoparan, Sinem Gül, Özge Arslan, Ömer Güllülü, and Merve Tuzlakoğlu-Öztürk Gebze Technical University, Kocaeli, 15:05-15:30 The Effect of the Plasma Membrane Content on Wnt-receptor Complex Activation Güneş Özhan, ibg-izmir, İzmir, Erdinç Sezgin, Yağmur Azbazdar and Güneş Özhan 15:30-16:00 Coffee Break + Poster 16:00-16:40 Session 3: Development and Stem Cell Biology Chair: Arzu Çelik, Boğaziçi University, Istanbul, Molecular mechanisms of induced plasticity and regenerative neurogenesis in vertebrate brains Çağhan Kızıl German Center for Neurodegenerative Diseases (DZNE) Dresden, Germany 16:40-17:05 Epigenetic Control of Lineage Commitment of Mouse Embryonic Stem Cells Nihal Terzi Çizmecioğlu Boston Children s Hospital/ Harvard Medical School, MA, USA 17:05-17:30 Klf5 Acts as a Differentiation Switch from Proliferation to Fusion in Myoblasts Ugur Akpulat, Yilmaz Yildiz, Cansu Ozdemir, Duygu Akcay, Cetin Kocaefe Hacettepe Univeristy, Ankara, 17:30-19:00 Welcome Coctail at KKM

3 28 November, Saturday 2015 Meetings will be held in parallel sessions in Salon A and B 9:30-10:30 KKM, Salon A Plenary Lecture Understanding Transcriptional Regulation in Breast Cancer; Towards the Development of New Targeted Cancer Therapies Simak Ali Imperial College of London, Surgery & Cancer, London, UK Chair: Rengül Çetin-Atalay, METU, Ankara, 10:30-11:00 Coffee Break + Poster 11:00-11:40 Salon A Session 4A: Plant Molecular Biology Chair: Hikmet Budak, Sabancı University, Istanbul, Keynote lecture Application of molecular tools in response to abiotic and biotic stress tolerance in model and complex plants species Hikmet Budak Sabancı University, Molecular Biology, Genetics & Bioengineering, Istanbul, 11:40-12:05 In vitro phytoremediation of nitroaromatic pollutants with transgenic plants Yelda Özden Gebze Institute of Technology, Molecular Biology and Genetics, Kocaeli, 12:05-12:30 Histone Acetylation Influences the Transcriptional Activation of POX in Beta vulgaris L. and Beta maritima L. under salt stress Seher Yolcu, Filiz Ozdemir, Aybüke Güler, Melike Bor Ege University, İzmir, 12:30-14:00 Lunch Break +Poster 14:00-14:40 Salon A Session 5A: Biochemistry Chair: Tülin Güray, METU, Ankara,

4 Targeting DNA repair pathways for cancer therapy: A synthetic lethal approach Meltem Müftüoğlu, Acıbadem University, Molecular Biology and Genetics, Istanbul, 14:40-15:05 Proteomic Analysis of Cell Division Nurhan Özlü Koç University, Molecular Biology and Genetics, Istanbul, 15:05-15:30 Timely and spatial control of exit from mitosis Ayse Koca Caydasi and Gislene Pereira German Cancer Research Center, Heidelberg, Germany 15:30-16:00 Coffee Break + Poster 16:00-16:40 Salon A Session 6A: Immunology/Microbiology Chair: Tolga Sütlü, Sabancı University, Istanbul, Keynote lecture DNA sensors and the Immune system in health and disease Mayda Gürsel, METU, Biological Sciences, Ankara, 16:40-17:05 Adenosine regulation of myeloid cells and anti-tumor immune responses Çağlar Çekiç Bilkent University, Molecular Biology and Genetics, Ankara, 17:05-17:30 Multiplex-PCR-Based Screening of Virulence Factors and its impact on T-Cell Mediated Immunity in Helicobacter pylori Infections Sinem Öktem Okullu, Arzu Tiftikçi, Murat Saruç, Bahattin Çicek, Eser Vardareli, Nurdan Tozun, Tanıl Kocagöz, Uğur Sezerman, Ahmet Sinan Yavuz and Ayça Sayı Yazgan ITU, Acıbadem Univeristy, & Sabancı University, Istanbul, 17:30-17:50 MBD Best PhD Thesis Award 2015 Microrna dependent control and regulation mechanisms of autophagy in health and disease Ayse Kumsal Tekirdag Kosar, Sabancı University, Istanbul, ; Albert Einstein College of Medicine, New York, USA

5 28 November, Saturday 2015 Meetings will be held in parallel sessions in Salon A and B 11:00-11:40 Salon B Session 4B: Neuroscience Chair: Deniz Atasoy, Medipol University, Istanbul, Defining the Epigenetic Origins of Mental Illness Reid S. Alisch University of Wisconsin School of Medicine Madison, WI, USA 11:40-12:05 Modeling myelin formation and myelination disorders using stem cells Bilal Ersen Kerman, Medipol University, Istanbul, 12:05-12:30 Genome-wide target analysis of NEUROD2 provides new insights into regulation of cortical projection neuron migration and differentiation Efil Bayam, Gülcan Semra Şahin, Gizem Güzelsoy, Gökhan Güner, Alkan Kabakçıoğlu, Gülayşe İnce-Dunn Koç University, Istanbul, 12:30-14:00 Lunch Break +Poster 14:00-14:40 Salon B Session 5B: Bioinformatics &Systems Biology Chair: Tolga Can, METU, Ankara, Dissecting the role of biological noise by single-cell analysis Savaş Tay ETH Zurich, Switzerland 14:40-15:05 Network Modeling Identifies Personalized Therapeutic Strategies in Glioblastoma Nurcan Tunçbağ METU, Informatics Institute, Ankara, 15:05-15:30 Predicting the Progression of Subclinical MGUS to Clinically Active MM in Multiple Myeloma Semih Alpsoy, Mehdi Ghasemi, Seyhan Türk, Sultan N. Can, Ali O. Güre, İbrahim C. Haznedaroğlu METU Technopark, METU & Hacettepe University, Ankara,

6 15:30-16:00 Coffee Break 16:00-16:40 Salon B Session 6B: Genomics/Proteomics Chair: Özlen Konu, Bilkent University, Ankara, Exome sequencing in Turkish patients implicate autophagy and ubiquitination in ataxia and developmental delay Margit Burmeister University of Michigan, Molecular and Behavioral Neuroscience Institute, MI, USA 16:40-17:05 A Non-parametric Mixed Membership Model to Leverage Biological Networks for the Analysis of Omics Data Aybar Acar, METU, Bioinformatics, Ankara, 17:05-17:30 Novel Resistance Mechanisms against Two Antifungal Drugs: Amphotericin B and Caspofungin Çiğdem IŞIK, Hana SYCHROVA, Ahmet KOÇ Izmir Institute of Technology, Izmir,; Academy of Sciences, the Czech Republic 19:30 Gala Dinner atvişnelik

7 29 November, Sunday :30-10:30 KKM, Salon A Plenary Lecture Title: Mike Yaffe, MIT, Biology and Biological Engineering, MA, USA Chair: Işık Yuluğ, Bilkent University, Ankara, 10:30-11:00 Coffee Break + Poster 11:00-11:40 Session 7: Cancer Biology Chair: N.C. Tolga Emre, Boğaziçi University, Istanbul, Keynote lecture 1 Unraveling therapy response and resistance in mouse models of human breast cancer Jos Jonkers Cancer Systems Biology Centre, NTCI, Amsterdam, Netherlands 11:40-12:20 Keynote lecture 2 Dietary control of stem cells in physiology and disease Ömer Yılmaz MIT, Biology, MA, USA 12:20-12:45 Alternative Polyadenylation Related 3 UTR Length Changes in Breast Cancer A. Elif Erson-Bensan METU, Biological Sciences, Ankara, 12:45-13:05 Activation of C/EBPβ-3 During Cellular Differentiation Links the Development of ER Stress and Autophagy in Colon Epithelial Cells Aslı Sade Memişoğlu, Sreeparna Banerjee METU, Ankara, 13:05-14:00 Posters and Adjourn/ MBG meeting (members only)