The Worst Headache of My Life A Diagnostic Dilemma
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1 July 2004 The Worst Headache of My Life A Diagnostic Dilemma Megan Coffee, HMS IV
2 History 68 yo woman c/o "worst headache of [her] life" after 3 wks of intermittent HAs. No neurologic deficits, seizures, CP, trauma 6/29/04. Pt called EMS. On EMS arrival, A+Ox3. En route became unresponsive, intubated PMH: HTN, Hyperchol Meds: Atenolol, Triamterene/ HCTZ, Lipitor. NKDA SH: Recent Travel across US, Lives alone 2
3 ED Presentation Febrile, Elevated WBC, Hypertensive (195/116). Tox screen, LP (2 RBCs, 0 WBCs), cardiac enzymes wnl EKG? Inferior MI CXR showed b/l interstitial infiltrates, probable cardiomegaly c/w CHF High on DDx: stroke, Subarachnoid Hemorrhage (SAH)? hemorrhage in pt with HTN and worst HA of her life 3
4 Head CT Our patient Archived SAH pt PACS, BIDMC, courtesy of Dr Kleefield Our patient: no intraparenchymal or extraaxial hemorrhage No increased attenuation in our patient s CSF, Sylvian fissure, basal cisterns or ventricular system. 4
5 Head CT Findings Head CT: Edema Largely Right Posterior Some loss of graywhite differentation and hypodensity in R occipital lobe. Subcortical white matter hypodensities. No midline shift, No hydrocephalus. Broad Differential: Tumor, Infection, Inflammation PACS, BIDMC 5
6 ED Course Pt intubated on propofol. Neuro exam: Comatose, non-focal Fundoscopic Exam: Disc Margins blurred. C/w CT findings of edema. Head MRI per radiology recommendation 5 hours after arrival 6
7 MRI MRI showed focus in R posterior region T2 axial Additionally, multiple cortical and subcortical enhancing lesions bilaterally in cerebral hemispheres and cerebellum Gray and white matter PACS, BIDMC 7
8 Enhancing Lesions Magnevist (Gadolinium-DTPA complex) is highly hydrophilic Brain uptake only if hydrophobic Blood Brain Barrier disrupted Enhancement on post- Gadolinium T1 images compared with T1 pre- Gadolinium images 8
9 Our patient s T1 Axial Images Pre and Post Gadolinium Pre Post PACS, BIDMC 9
10 Our patient s T1 Axial Images Pre and Post Gadolinium Pre Post PACS, BIDMC 10
11 Our patient s T1 Axial Images Pre and Post Gadolinium Pre Post PACS, BIDMC 11
12 Our patient s T1 Axial Images Pre and Post Gadolinium Pre Post Multiple bilateral enhancing cerebellar lesions PACS, BIDMC 12
13 Our patient s T1 Axial Images Pre and Post Gadolinium Pre Post PACS, BIDMC More cerebellar enhancing lesions 13
14 T1 Axial Images Pre and Post Gadolinium Pre Post PACS, BIDMC 14
15 T1 Axial Images Pre and Post Gadolinium Temporal Lobe apparently spared, enhancing lesions in occipital Pre Post Temporal lobe Occipital lobe PACS, BIDMC 15
16 T1 Axial Images Pre and Post Gadolinium Pre Post PACS, BIDMC 16
17 T1 Axial Images Pre and Post Gadolinium Pre Post PACS, BIDMC 17
18 T1 Axial Images Pre and Post Gadolinium Pre Post Basal Ganglia and Thalamus spared PACS, BIDMC 18
19 T1 Axial Images Pre and Post Gadolinium Pre Post PACS, BIDMC 19
20 T1 Axial Images Pre and Post Gadolinium Pre Post PACS, BIDMC 20
21 T1 Axial Images Pre and Post Gadolinium Pre Post Frontal Lobe PACS, BIDMC Corona Radiata (and optic radiation) relatively spared 21
22 T1 Axial Images Pre and Post Gadolinium Pre Post PACS, BIDMC 22
23 T1 Axial Images Pre and Post Gadolinium Pre Post PACS, BIDMC Question of a watershed distribution (Middle Cerebral and Anterior Cerebral Arteries) 23
24 T1 Axial Images Pre and Post Gadolinium Pre Post PACS, BIDMC Possible watershed distribution in Parietal lobes bilaterally 24
25 T1 Axial Images Pre and Post Gadolinium Pre Post PACS, BIDMC 25
26 T1 Axial Images Pre and Post Gadolinium Pre Post PACS, BIDMC 26
27 T1 Axial Images Pre and Post Gadolinium Pre Post PACS, BIDMC 27
28 T1 Gadolinium Findings Multiple enhancing nodular lesions predominantly in occipitoparietal region bilaterally (R>L) Lesions in frontal lobe Temporal lobe, Basal ganglia, and Brain Stem spared Possible watershed distribution (MCA, ACA) 28
29 Fluid-Attenuated Inversion- Strong T2 weighting + CSF suppression Recovery (FLAIR) High lesion to tissue contrast Spin-echo technique Possible CSF pulsation artifact High sensitivity for MS, SAH 29
30 Fluid-Attenuated Inversion- Recovery (FLAIR) PACS, BIDMC Prominent hyperintensity in posterior distribution, R>L c/w Edema 30
31 Fluid-Attenuated Inversion- Recovery (FLAIR) PACS, BIDMC Possible Edema in posterior region 31
32 Diffusion Weighted Images (DWI) Hyperintensity points to Acute Ischemia DWI measures the diffusion of water molecules. (Brownian Motion) 2 pulses tag and catch Hydrogen. 1 st pulse dephases spins 2 nd pulse rephases the spins if no net movement. If between pulses, there is net movement, signal is attenuated In acute ischemia, blood flow is lowered. Sodium enters cells, followed by H20-> cytotoxic edema. Water movement now restricted within cell membranes. Image from 32
33 Diffusion Weighted Image (DWI) Right posterior parietal region raised question of small associated infarction. T2 Axial DWI PACS, BIDMC However, may be an artifact of T2 shine through. High T2 weighting may yield this apparent lesion on DWI and may represent the strong lesion seen on T2. 33
34 Gradient Echo (GRE) T2 weighted technique sensitive to magnetic field inhomogeneity, such as created by paramagenetic materials. GRE Axial DWI Axial Hypointense lesion may represent hemosiderin from small hemorrhage. No evidence of lacunar infarcts c/w HTN hemorrhages 34
35 Magnetic resonance angiography MRA MRA showed a complete Circle of Willis. No aneurysms or other vascular abnormalities seen P Comm Right PCA Right ACA Diminutive Right vertebral Left MCA Basilar Left ICA Left vertebral Images derived from Time of Flight based on blood flow PACS, BIDMC ACA=Anterior Cerebral Artery, MCA= Middle Cerebral Artery, PCA=Posterior Cerebral Artery, ICA =Internal Carotid Artery 35
36 MRI Impression Innumerable nodular enhancing foci predominantly in watershed distribution in cerebrum and cerebellum with edema. Primarily parietal, occipital, and frontal lobes. Possible small posterior parietal area of new infarction with minimal hemorrhage T1 sagittal post-gadolinium 36
37 Differential Diagnosis Hypertensive Leukoencephalopathy Multiple Sclerosis Neurosarcoid/other granuloma Small Vessel Vasculitis Acute Disseminated Encephalomyelitis(ADEM) Infectious Encephalitis 37
38 Hypertensive Encephalopathy Pro Patient was hypertensive (195/116 in ED) Possible subacute presentation MRI classically shows primarily posterior lesions in gray and white matter. FLAIR and DWI show lesions with edema Hypertensive Encephalopathy T2 Con Lesions normally not enhancing Centrally located, usually spares calcarine cortex/sulcus Rarely involves Cerebellum 38
39 Multiple Sclerosis (MS) Pro Multiple lesions, enhancing seen also on T2, FLAIR Con Single attack Plaques usually periventricular or in corpus callosum MS plaques normally ovoid Large number of lesions for initial presentation Image from 39
40 Neurosarcoidosis Pro Presents with Multiple White Matter Lesions Can affect any part of the CNS Con Unlikely, but possible, without lung involvement on CXR Neurosarcoidosis usually in base of the brain and midline, affecting hypothalamus and pituitary May include space occupying lesions 40
41 Brain Biopsy On Hospital day #3, our patient had a brain biopsy to evaluate for vasculitis or other unknown etiology Biopsy showed: Subacute Encephalomyelitis Infectious(Viral) vs Immunologic(MS, ADEM) Cytology negative for malignancy 41
42 ADEM Acute demyelination after viral infections or vaccine Usually in children Often mistaken for MS, but has resolution of symptoms Causes include (zoster, measles, rubella, HSV, coxsackie, echo, polio, CMV, EBV, VZV, influenza, and parainfluenza, Japanese Encephalitis Vaccine). As well as Mycoplasma pneumoniae, Listeria, Streptococcus, and typhus. T1 images post gado Images from 42
43 ADEM and MRI ADEM results in perivascular edema, inflammation, and demyelination.?vasculitis MRI: Multifocal, asymmetric white or gray matter lesions Lesions resolve with time Lesions can be enhancing, associated with edema, and found in b/l hemispheres, cerebellum, and basal ganglia MR Spectroscopy shows promise in determining chemical composition of lesions to differentiate from MS 43
44 Viral Encephalitis Clinical Encephalitis (Elevated WBC, fever, recent travel) Persons with cerebrovascular disease (HTN, Hypercholesterolemia) are at increased risk of viral encephalitis 44
45 Causes of Viral Encephalitis Herpes Encephalitis West Nile Virus St Louis Encephalitis Western/Eastern Equine Encephalitis Influenza HIV Enterovirus Measles, Subacute Sclerosing Panencephalitis Herpeseviridae (EBV/CMV/HHV6/HHV7) Progressive Multifocal Leukoencephalopathy Japanese Encephalitis Nipah Virus?Von Economo 45
46 Treatable Encephalitis HSV HIV CMV, EBV, HHV6, HHV7 Influenza Vaccine for Japanese Encephalitis Question of whether steroid treatment (often for cerebral edema) is harmful for viral encephalitis 46
47 Unlikely HSV Encephalitis Classically Temporal Lobe (spared in our patient) Medial temporal and frontal lobe first affected due to intracranial spread from meningeal branches CN V. Insular cortex (sparing lentiform nucleus). Limbic system spread and later pontine involvement K Martin, C Franco-Paredes. The Lancet. Oct , 9342; 1286 Edema, then Hemorrhage and Necrosis. Most common encephalitis in US 47
48 West Nile Virus Close to 10,000 cases in US with >20% Mortality Mostly Western States MRI shows diffuse lesions with enhancement, but often targets substantia nigra (unlike our patient) St Louis Encephalitis closely related, seen in Southern US Solomon NEJM. 351 (4):
49 Equine Encephalitis Eastern, Western, Venezuelan Rare (8 cases/yr in US of Eastern and Western) Eastern in MA Multiple enhancing lesions common Usually in Basal Ganglia, Thalami as seen in this pt T1 post Gado NEJM :
50 Immunocompromised Disease Patient not immunocompromised Lesions rarely enhancing given immunocompromise and lack of inflammation HIV results in atrophy, large ventricles PML is demyelinating CMV, EBV, HHV6, HHV7 HIV Atrophy T2 50
51 Exotic Encephalitis Japanese Encephalitis, Nipah, Murray Valley No known domestic transmission South East Asia (Nipah recently emerged from pig virus; Murray Valley in Australia and Papau New Guinea) Result in punctate central lesions, predominantly in Thalami (JE) and Basal Ganglia (both) Infection often unrecognized until Parkinsonism sequelae 51
52 The Verdict Most likely ADEM Cause infectious, post-infectious, or autoimmune Exacerbated by HTN ADEM precipitant unknown If Viral possibly West Nile, St Louis, Eastern Equine, or Enterovirus given travel history, lack of immunosuppression, and MRI, but radiologic presentation is not classic 52
53 Patient s progress Pt placed on IV steroids in Neuro ICU Pt improved neurologically, began nodding replies Extubated after 3 days Discharged after 2 weeks to long term care A+Ox3, speech fluent. Residual mild L hemineglect, distal lower extremity weakness. Sister reported possible URI/Earache prior to HA which may represent ADEM precipitant or viral prodrome 53
54 Useful References Solomon T.Current Toprics: Flavivirus Encephalitis.N Engl J Med 2004; 351: , Jul 22, 2004 Woodruff, W. Fundamentals of Neuroimaging Saunders, Philadelphia Huk, WJ et al. MRI of Central Nervous System Diseases Springer-Verlag, NY Grossman, RI and DM Yousem. Neuroradiology, The Requisites Mosby, NY Greenfield s Neuropathology. Editors Graham and Lantos HDI, NY Mascke M et al. Update on Neuroimaging in Infectious Disease in the Central Nervous System Current Opinion Neurology Deresiewicz R. L., Thaler S. J., Hsu L., Zamani A. A. Clinical and Neuroradiologic Manifestations of Eastern Equine Encephalitis. N Engl J Med 1997; 336: Martin K, C Franco-Paredes. Lancet , 9342;
55 Special Thanks to: Jonathan Kleefield, MD who recommended this project and identified the patient Amy Amick, MD and Elijah Owens, MD who cared for the patient Mathew Anderson who discussed his pathology findings Michael Goldfinger, MD and Jason Handwerker, MD who were first the radiologists on the case Nicole Nelson, MD Pamela Lepkowski Larry Barbaras, webmaster 55
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