1 Asbestos and Related Durable Fibers: Too Ubiquitous, Too Persistent, Too Complex to Put Health Risks to Rest? Philip M. Cook Mid-Continent Ecology Division National Health and Environmental Effects Research Laboratory Duluth, Minnesota
2 Are health effects from exposures to microscopic durable fibers an old issue? An extensive history of research, discussion and debate which focused on occupational exposures to a few types of asbestos fibers has not lead to an understanding of all risks. Asbestos is more of a slowly expanding pollutant problem than a re-emerging one. A hallmark complication for risk assessment is the very long lag time between exposure and effects.
3 Objectives for this presentation*: Provide overview of asbestos health risks. Give examples of EPA s experience with asbestos-like fibers. Describe why we need and how we can develop a relative potency model for assessing risks from complex mixtures of mineral fibers and new synthetic fibers. Comment on similarity of some synthetic nanofibers to asbestos. *The content of this presentation represents the experience and opinions of the author and not U.S. EPA procedures or policies.
4 Chrysotile asbestos cross-fiber vein Amphibole crystals in taconite (iron ore) - ferroactinolite replacing hornblende 5 cm
5 Asbestos fibers - TEM (high magnification) bundles and fibrils of chrysotile asbestos fibers rodlike bundle of crocidolite asbestos fibers
6 Evolution of Risk Assessment: The Early Years If we go out today, one of us will probably be eaten! It's not safe to go in there after them!
7 Tempus fugit It s a fiber! > 5 micrometers Transmission Electron Microscope (TEM)
8 Tremolite acicular Cleavage Fragments?
9 Amphibole asbestos fibers have complex crystalline structures that may regulate size and shape changes in response to physical, chemical and biological processes. Cleavage of asbestiform fibers can occur and the resulting fibers (cleavage fragments?) are unlikely to be less toxic than the original fibers.
10 Diseases Associated with Inhaled Asbestos Tremolite
11 Phagocytosis of asbestos fibers pulmonary alveolar macrophage cell attempting to engulf and ingest several long crocidolite asbestos fibers incomplete ingestion of asbestos fibers can lead to extensive selective release of proteolytic enzymes and ROS from the frustrated PAMs
12 Ferrugenous bodies in lung tissues
13 Lincoln County: times US Ave. Mortality Rates (ATSDR, NIOSH)
14 Loci of Cancers Associated with Asbestos Fiber Exposures Lung (smoking is a strong co-factor) Pleura - Mesothelioma Peritoneum - Mesothelioma Gastrointestinal tract Kidney Times from low dose exposures to observations of disease are long: years lag time
15 epidemiology Conceptual Model for development of methods for prospective assessment of health risks associated with exposures to mineral fibers Effects toxicology dose-response rel. potencies Dose in tissues respiration Exposures retention/clearance fate/transport Sources translocation Key question: what dose in tissues/lung should not be exceeded? Temporal exposure issues - lifetime, short term, early life stages
16 Libby MT - old mine, new concerns
17 Zonolite Mine - Libby, MT Vermiculite mine started 1920 s About 6 miles from town Produced up to 80% of worlds vermiculite Reportedly processed over 300,000 lbs/day 5000 lbs/day of asbestos into the Libby Airshed WR Grace bought in 1963 & closed in 1990.!Products: construction aggregate, fireproof coatings, insulation, soil additive, fertilizer
18 Over 300 Processing Plants Nationwide
19 Iron Formations of the Lake Superior Region
20 Taconite tailings discharge and delta
21 Transport of fine tailings particles caused turbidity in western Lake Superior
22 TEM view of particles in Duluth MN drinking water
23 Cook and Olson, Science, 1979
24 Dry cobb tailings <2 µm fraction
25 Dry cobb tailings <2 µm fraction decant
26 Background Concerns for risks associated with non-occupational exposures to mineral fibers (e.g. Reserve Mining Case), and interest in effects of synthetic fibers led to EPA research on effects associated with a wide variety of durable fibers during the period of Determination of carcinogenic potencies relative to known asbestos materials was a major objective. The EPA laboratory at Duluth provided electron microscopic characterizations of samples used in biological tests, quantitative measurements of fiber doses in test animals, and determinations of doseresponse relationships.
27 Intratracheal and Intrapleural Exposures of Fischer-344 Rats Primary objective was to determine relative potencies of different fiber types for carcinogenesis Studies included two samples of amphibole from taconite at Peter Mitchell Pit - ferroactinolite (fibrous) and grunerite (non-fibrous) Details of bioassays and effects provided in Coffin et al. Toxicology Letters, 1982 Details of quantitative dose-response analysis provided in Cook et al. Toxicology Letters, 1982
28 G/A ReP: <0.7 <200 <2.7 PRIMARY TUMORS 5 % TUMORS 4 LUNG 3 LUNG PLEURA 0 A F G PLEURA F/A ReP:
29 PRIMARY TUMORS 40 % TUMORS 30 PLEURA 20 PLEURA 10 0 LUNG 0 LUNG A F G F/A ReP: G/A ReP: <0.3 <70 <1.6
30 All Fibers
31 Short thin fibers
32 Eureka! ferroactinolite fibers were dissolving and splitting longitudinally while residing in rat lung tissues over time.
33 Anthophyllite in human lung
34 Conceptual Model for Carcinogenic Potency - Pott, 1978
35 Relative Carcinogenicity Factors from Pott (1978) 2.5 to 5 um 1.25 to 2.5 um 0 to 1.25 um 5 to 10 um 20 to 40 um 10 to 20 um 0 to um to um to um um to 0.25 um 0.25 um to 0.5 um 0.5 um to 1.0 um 1.0 um to 2.0 um RCF = fraction of maximum potency/fiber
36 Carcinogenicity Equivalence Dose (CED) A CED is the number of most potent fiber equivalents in the lung or pleura that results in a defined % of tumors. CED = Σ(RCF i,j )(C i,j ), where C i,j = # fibers/organ, RCF is the relative carcinogenicity factor (0-1), and i,j defines each of i"j length/width categories. The smaller the sample s CED, the greater the predicted potency for individual fibers. If amphiboles have equipotent fibers within specified size and shape ranges and the associated RCF values are reasonable, CEDs should be similar.
37 Rat Intratracheal Instillation Amosite 2.5 to 5 um 1.25 to 2.5 um 0 to 1.25 um 5 to 10 um 10 to 20 um 20 to 40 um 0.5 um to 1.0 um 0.25 um to 0.5 um um to 0.25 um to um to um 0 to um 1.0 um to 2.0 um Carcinogenicity Equivalence Dose = 345 million fibers/lungs
38 Crocidolite 2.5 to 5 um 1.25 to 2.5 um 0 to 1.25 um 5 to 10 um 10 to 20 um 20 to 40 um 0.5 um to 1.0 um 0.25 um to 0.5 um um to 0.25 um to um to um 0 to um 1.0 um to 2.0 um Rat Intratracheal Instillation Carcinogenicity Equivalence Dose = 405 million fibers/lungs
39 Rat Intratracheal Instillation Ferroactinolite (PMPI) 2.5 to 5 um 1.25 to 2.5 um 0 to 1.25 um 5 to 10 um 20 to 40 um 10 to 20 um 0.5 um to 1.0 um 0.25 um to 0.5 um um to 0.25 um to um to um 0 to um 1.0 um to 2.0 um Carcinogenicity Equivalence Dose = 22 million fibers/lungs
40 Rat Intratracheal Instillation Ferroactinolite (PMPI) one year in rat lungs 2.5 to 5 um 1.25 to 2.5 um 0 to 1.25 um 5 to 10 um 10 to 20 um 20 to 40 um 0.5 um to 1.0 um 0.25 um to 0.5 um um to 0.25 um to um to um 0 to um 1.0 um to 2.0 um Carcinogenicity Equivalence Dose = 132 million fibers/lungs
41 Summary of fiber carcinogenicity equivalence doses (CEDs) from relative carcinogenicity factors (RCFs) based on Pott s hypothesis Units for CEDs are millions of most potent fibers in lung per 5% tumors (IT) or in pleura per 30 % tumors (IP) amosite crocidolite ferroactinolite ferroactinolite one year non-fibrous grunerite Intratracheal >? Intrapleural >? The greater the CED, the less potent the amphibole (if RCFs are accurate) Proposal: greater RCFs for short and thin fibers than those proposed by Pott should be investigated and considered.
42 Conclusions Fiber splitting in vivo greatly enhanced the potency of ferroactinolite in rat studies. Short and thin amphibole fibers appear to affect toxicity. If not, long ferroactinolite fibers would have to be regarded as many times more potent than long amosite or crocidolite fibers. Because risk is a function of cumulative fiber dose, exposures should be measured on the basis of all fiber sizes with consideration of relative carcinogenicity and fibrogenicity of different size and shape categories. Similarly, exposure predictions should be based on all fiber sizes so that relative potencies can be included in risk assessments.
43 Adjust Relative Carcinogenicty Factors to Determine Optimum Values Pott assumed short fibers have very low potencies and did not increase potency of very thin fibers. Cook suggests modest increase of RCFs for short, thin fibers. If all amphibole fibers have potencies primarily determined by fiber size and shape, carcinogenicity equivalence doses should be similar.
44 Carcinogenicity Equivalence Doses 600 with Alternative RCFs Million fibers/lungs for 5% tumors -IT * More Potent Pott RCFs Cook RCFs 0 Amosite Crocidolite Ferroact Ferroact 1yr * For Cook RCFs, Amosite and Crocidolite CEDs at 1 year # Ferroactinolite CED at 1 year.
45 Mean Shapes and Sizes of Fiber Types Amosite Grunerite Crocidolite Ferroactinolite Exposure 628 f/ng 40 f/ng 3360 f/ng 54 f/ng Rat Lung One Year 205 f/ng 31 f/ng 464 f/ng 411 f/ng
46 Mean Shapes and Sizes of Fiber Types Chrysotile Glass Erionite Exposure f/ng 5660 f/ng 850 f/ng Rat Lung One Year 5490 f/ng 436 f/ng
47 Conclusions continued Need to determine fiber residence time in lung for optimal expression of potency in rats and humans in order to better define and extrapolate dose-response relationships. Quantitative TEM analyses may be used to calibrate PLM, XRD, and other analytical methods which can not directly measure all fibers in exposure assessments.
48 Risk Assessment Limitations Perpetuated by Narrow Definitions of Hazardous Fibers No methodology for assessing risks from short fibers - need a relative potency model Weak links to mechanism of action data Unable to provide precise definition of undesirable synthetic fibers so that safe alternatives can be developed Human dose-response relationships are very uncertain and may be inaccurate
49 Properties of microscopic fibers that indicate potential for causing asbestos-like pathologies Size and shape that allows respiration, retention in lungs, and translocation to pleura Durable, persistent in tissues Reactive surfaces, ability to induce ROS High collective surface area Propensity to split into thin fibers in vivo
52 Potential Applications of Carbon Nanofibers Additives in ploymers Catalysts Electron field emitters for cathode ray lighting elements flat panel display gas-discharge tubes in telecom networks Electromagnetic-wave absorption and shielding Energy conversion Lithium-battery anodes Hydrogen storage Nanotube composites (by filling or coating); Nanoprobes for STM, AFM, and EFM tips nanolithography nanoelectrodes drug delivery sensors Reinforcements in composites Supercapacitor Zeolite tubes
53 Carbon nanofibers are used to produce zeolite nanotubes
54 Sizes of zeolite nanotubes can be controlled to reduce risks - if we know what sizes are non-hazardous
55 Effective environmental protection requires that each new generation advances the knowledge passed on by the previous generation
Endereço eletrônico http://www.atsdr.cdc.gov/asbestos/asbestos_whatis.html Search Index Home Glossary Contact Us CONTENTS Asbestos What Is Asbestos? Polarized Light Microscopy Slide of Asbestos Fibers.
Page 1 of 6 skip navigational links This is an archive page. The links are no longer being updated. Statement by Gregory R. Wagner, M.D. Director, Division of Respiratory Disease Studies National Institute
Naturally Occurring Asbestos (NOA) General Overview Lee R. Shull PhD Health, Ecology and Risk Practice MWH Global Sacramento, CA CASH NOA Workshop January 24, 2006 Presentation Outline Brief background
Analysis of Asbestos in Soil Hazel Davidson Technical Marketing Manager Diversity of asbestos materials Methods of analysis Problems and issues The way forward Types of asbestos: Chrysotile (white), Amosite
Cancer Risk Factors in Ontario Dusts and Fibres dusts ANd fibres risk factor/exposure Cancer The context where high risks were reported Magnitude of risk* Strength of evidence a Asbestos Larynx Occupational
Update of the scientific evidence on asbestos and cancer Kurt Straif, MD MPH PhD International Agency for Research on Cancer Lyon, France World Health Organisation Asturias, 17 March 2011 The IARC Monographs
Sir William Osler: Listen to the patient; the patient tells you everything. Jean-Martin Charcot: The patient is a liar. Epidemiology of Mesothelioma Jeffrey H. Mandel, MD, MPH Division of Environmental
Influence of Fiber Type, Size, and Number in Human Disease: Conclusions from Fiber Burden Analysis Andrew Churg, MD Department of Pathology University of British Columbia Vancouver, BC, Canada Techniques,
BE.104 Spring Evaluating Environmental Causes of Mesothelioma J. L. Sherley Outline: 1) Toxicological mechanisms and causation evaluations 2) An environetics case: Asbestos and Mesothelioma Toxicological
Asbestos General information Key Points Fire Non flammable and non combustible under normal conditions Chemically inert under normal conditions. Resistant to most solvents, acids and alkalis In the event
Scientific Update on Safe Use of Asbestos Robert P. Nolan, PhD International Environmental Research Foundation New York, New York www.ierfinc.org When We Talk about Asbestos What Do We Mean? Anthophyllite
Comments of Professor Richard Wilson Department of Physics & Center for Risk Analysis Harvard University Cambridge, Massachusetts On the Proposed Asbestos Ban Senate Employment and Workplace Safety Subcommittee
The Health Effects of Dusts The Health Effects of Dusts Some aspects have been well known for decades General effects of industrial / commercial asbestos Silicosis (hard rock mining) Black lung (coal mining)
This Public Health Statement is the summary chapter from the Toxicological Profile for Asbestos. It is one in a series of Public Health Statements about hazardous substances and their health effects. A
Toxicity of Amphibole Asbestos Disclaimer: The material presented in these slides has been reviewed by the U.S. EPA and approved for presentation. Approval does not signify that the contents necessarily
Asbestos & Cancer: An Update Suresh H. Moolgavkar, M.D., Ph.D. Fiber Type and Cancer Epidemiological data clearly indicate that not all fiber types have the same potency as carcinogens. With respect to
Environmental Health Perspectives Vol. 7, pp. 51-56, 1986 Contribution of Environmental Fibers to Respiratory Cancer by Gilbert S. Omenn,* James Merchant,t Edwin Boatman,* John M. Dement, Marvin Kuschner,"
Health Effects of Asbestos Exposure Jill Dyken, PhD, PE John Wheeler, PhD, DABT Agency for Toxic Substances and Disease Registry Asbestos Science Seminar Folsom, California August 18-19, 2004 Agency for
Asbestos: health effects and risk Peter Franklin Senior Scientific Officer, EHD Senior Research Fellow, UWA What is asbestos Naturally occurring mineral that has crystallised to form long thin fibres and
News release from the Royal Society of New Zealand and the Office of the Prime Minister s Chief Science Advisor 15 April 2015 Asbestos exposure during Canterbury rebuild unlikely to cause significant health
What is nanotoxicology? How to estimate the potential hazard related to nanoparticles? Dissemination report October 2008 DR-225 200810-5 Project ID NMP2-CT-2005-515843 An European Integrated Project Supported
Asbestos Presence in a Factory that Produced Asbestos-Containing Products Hana Fajkovi Department of Geology, Faculty of Science, University of Zagreb, Horvatovac 95, 10000 Zagreb, Croatia, e-mail: (firstname.lastname@example.org)
STANDARDS Toxic and Hazardous Substances, Title 29 Code of Federal Regulations (CFR) Part 1910.1001, Subpart Z Asbestos 1. INTRODUCTION IWU has a responsibility to provide a safe environment for students,
Asbestos in Vermiculite and Vermiculite Containing Products IFMA February 18th, 2014 EMSL Analytical, Inc. Edward Cahill, VP, Asbestos Division Email: email@example.com EMSL Analytical, Inc. 200 Route 130
334 Asbestos-Related Lung Cancer and Malignant Mesothelioma of the Pleura: Selected Current Issues Steven Markowitz, MD, DrPH 1 1 Barry Commoner Center for Health and the Environment, Queens College, City
Available online at www.sciencedirect.com Regulatory Toxicology and Pharmacology 52 (2008) S154 S186 www.elsevier.com/locate/yrtph An evaluation of the risks of lung cancer and mesothelioma from exposure
Asbestos Asbestos Disease: An Overview for Clinicians Asbestos Exposure Asbestos: A health hazard Exposure to asbestos was a major occupational health hazard in the United States. The first large-scale
All About Asbestos Read this booklet to learn more about: identifying asbestos-containing material in your home the health risks of asbestos what you can do about asbestos. What is Asbestos? Asbestos is
ASBESTOS AWARENESS Asbestos Awareness Asbestos is a serious health hazard commonly found in our environment today. This module is designed to provide initial education of asbestos and its associated hazards.
Science-Based Facts Relevant Health Issues 2015 For environmental occupational health safe and responsible use SCIENCE-BASED FACTS AND RELEVANT HEALTH ISSUES 2015 ON THE DIFFERENT ASBESTOS FIBER TYPES:
An Evaluation of the Risks of Lung Cancer and Mesothelioma from Exposure to Amphibole Cleavage Fragments John F. Gamble, Ph. D. International Environmental Research Foundation Post Office Box 3459 Grand
ASBESTOS Know what it is and how you can protect yourself environmental affairs Department: Environmental Affairs REPUBLIC OF SOUTH AFRICA 1 What is asbestos? The term asbestos designates a group of naturally
ASBESTOS AWARENESS For workers and building occupants Asbestos Awareness Asbestos is a serious health hazard commonly found in our environment today. This module is designed to provide an overview of asbestos
Ann. occup. llyy.. Vol.. Mos. I 4. pp. 4-4. 98. Primed in Great Bnlain. Inhaled Panicles V 0003 4878/8,004-OSO3.00/O Pergamon Press Lid. (' 98 British Occupational Hygiene Society. ASBESTOS FIBRES IN THE
Asbestos Hazards and Controls Environmental and Occupational Health Public Health Ontario Photo provided with the kind permission of Infrastructure Health & Safety Association 5110 Creekbank Road, Mississauga,
Facilities Operations and Development Environmental Health & Safety 1314 Kinnear Rd. Columbus, Ohio 43212 Phone (614) 292-1284 Fax (614) 292-6404 http://fod.osu.edu The Ohio State University Asbestos Management
BY THE NUMBERS: THE FUTURE OF MESOTHELIOMA IN AMERICA 1 CUTTING-EDGE ISSUES IN ASBESTOS LITIGATION CONFERENCE Scott Masterson Lewis, Brisbois, Bisgaard & Smith, LLP 1180 Peachtree Street, NE, Suite 2900
Asbestos in the Home MISAWA AB, JAPAN Asbestos Awareness OCCUPANT ACKNOWLEDGEMENT OF INFORMATION SIGNATURE UNIT NUMBER DATE Prepared by: 35 CES/CEV If you have further question about location of asbestos
Asbestos and Mesothelioma in Ontario May 29, 2010 CARWH Conference: Worker Health in a Changing world of work Loraine Marrett, PhD Outline Part I: Asbestos & its uses Part II: Asbestos & cancer Part III:
ASBESTOS AWARENESS at THE UNIVERSITY AT ALBANY University at Albany Office of Environmental Health and Safety 2010 Introduction - ASBESTOS WHAT IS IT? ASBESTOS is a fibrous material that occurs naturally
Uses and Abuses of Pathology in Asbestos-exposed Populations Jerrold L. Abraham, MD Department of Pathology State University of New York Upstate Medical University Syracuse, NY, 13210 USA The term: Asbestosis,
Ingraham Environmental Inc. is committed to working with you to ensure that the environments where you live, work, and play are safe. We strive to provide you with the knowledge, experience and facts you
Asbestos The term asbestiform describes a mineral habit characterized by long, thin, strong, flexible fibers equivalent to hairs or whiskers How long? Definition varies Modern Uses of Asbestos Asbestos
Asbestos Awareness at the University of Toronto What is Asbestos? Asbestos is a general term given to a group of naturally occurring mineral silicates that are made up of long thin fibres. These fibrous
Asbestos Awareness What is Asbestos? Why was asbestos used? Asbestos appealed to manufacturers and builders for a variety of reasons. It is strong yet flexible, and it will not burn. It conducts electricity
Known to be a Human Carcinogen Eighth Report on Carcinogens ASBESTOS CAS No. 1332-21-4 First Listed in the First Annual Report on Carcinogens CARCINOGENICITY There is sufficient evidence for the carcinogenicity
Asbestos Trends Worldwide, with Richard Lemen Ashley Ahearn Views and opinions expressed in these podcasts are those of the interview subjects and do not necessarily reflect the views, opinions, or policies
June 2012 This fact sheet provides information to people who are trying to determine whether there is asbestos-containing material in their home or workplace, and what they might do if there is asbestos.
1 Risk Anal. 2004 Jun;24(3):547-52. Related Articles, Links Mesothelioma among brake mechanics: an expanded analysis of a casecontrol study. Hessel PA, Teta MJ, Goodman M, Lau E. Exponent, Wood Dale, IL
Asbestos Awareness Training Topics Uses and forms of asbestos; Common locations of asbestos containing building materials (ACBM); Health effects from exposure; Recognition of ACM damage and deterioration;
The British Occupational Hygiene Society Faculty of Occupational Hygiene INTERNATIONAL MODULE SYLLABUS W504 ASBESTOS AND OTHER FIBRES Aim: Learning Outcomes: This module enhances the student s knowledge
New York State Department of Health Center for Environmental Health Public Health Consultation Results of Air Exposure Investigation PRIMA ASPHALT CONCRETE INC (PAVCO) HAMLET OF HOLBROOK, TOWN OF BROOKHAVEN,
NISG Asbestos Caroline Kirton 1 The Control of Asbestos Regulations 2012, Regulation 10 requires every employer to ensure that adequate information, instruction and training is given to their employees
ERZSÉBET TÓTH (Eötvös L. University, Budapest): ASBESTOS-RELATED DISEASES AND REGULATIONS Outline 1. History and legal definition (mineralogy + morphology) 2. The useful properties of asbestos, its success
Asbestos Health Risks Dr Andrew Pengilley Acting Chief Health Officer Asbestos Asbestos is a name given to several different fibrous minerals Three main commercial types are Chrysotile (white asbestos)
Asbestos Awareness Asbestos is a serious health hazard commonly found in our environment today. This module is designed to provide an overview of asbestos and its associated hazards. It is important for
Elimination of Asbestos- Related Diseases WHO action Dr Ivan D. Ivanov Public Health and Environment WHO Headquarters Worldwide 125 million people are exposed to asbestos (mostly chrysotile) 75 million
Epidemiological insight into occupational causes of respiratory cancers Fraser Brims Epidemiological insight into occupational causes of respiratory cancers The following relevant disclosures, conflicts
Module Three Risk Assessment 136 Module Three Introduction to Risk Assessment Time Allotted: 90 Minutes Objectives: Upon completion of this module, the learner will be able to # Define and understand the
Health Consultation FORMER ZONOLITE COMPANY/ W.R. GRACE FACILITY ST. LOUIS 1705 SULPHUR AVENUE CITY OF ST. LOUIS, MISSOURI EPA FACILITY ID: MON000703779 AUGUST 16, 2006 U.S. DEPARTMENT OF HEALTH AND HUMAN
Health Consultation Residual Soil and Indoor Asbestos Assessment WESTERN MINERAL PRODUCTS SITE MINNEAPOLIS, HENNEPIN COUNTY, MINNESOTA EPA FACILITY ID: MNN000508056 Prepared by The Minnesota Department
A Discussion of Asbestos Detection Techniques for Air and Soil August 2004 Prepared by Anthony Perry National Network of Environmental Management Studies Fellow for U.S. Environmental Protection Agency
ASBESTOS Presented by: Samar Khalil Environmental & Chemical Safety Officer Outline What is Asbestos? Properties of Asbestos Where is Asbestos found? When is Asbestos dangerous? Health effects of Asbestos
Health Consultation Former California Zonolite/W.R. Grace & Company Site 5440 West San Fernando Road Glendale, Los Angeles County, California USEPA Facility ID: CAN000905898 and CAN000905894 June 14, 2007
Why TEM is essential in the measuring the concentration of airborne asbestos fibers Dr Maxime MISSERI THE AIRBORNE ASBESTOS FIBERS Six minerals that can divide into very thin fibers, have been recognized
Understanding Asbestos: Implications for the Individual and the Community Development Practitioner By Eric Fortner, Project Consultant firstname.lastname@example.org June 2014 EXECUTIVE SUMMARY Asbestos is
Asbestos Poisoning in Libby, Montana Namrata Dangol 11/25/2012 Abstract: Vermiculite mine was discovered in Libby, Montana in early 1910s. The mine provided jobs to town people and provided about 80% world
University of Nevada, Reno ASBESTOS AWARENESS TRAINING PROGRAM For workers and building occupants John A Braun, CSP Asbestos Awareness OSHA Standards for Asbestos are: 29 CFR 1910.1001 applies to all occupational
Comments of Professor Richard Wilson Department of Physics & Center for Risk Analysis Harvard University Cambridge, Massachusetts On the Proposed Asbestos Ban Senate Employment and Workplace Safety Subcommittee
University of Michigan Dearborn The Department of Environmental Health and Safety & Emergency Management Asbestos Management Program General What is Asbestos? Asbestos is the name applied to six naturally
Asbestos Toxicological overview Kinetics and metabolism Key Points Short asbestos fibres are deposited in the upper respiratory tract where they are cleared by mucociliary action Longer fibres are carried
Libby Asbestos Site Libby, Montana U.S. Environmental Protection Agency Region 8, ATSDR, PHS, US DOT-Volpe November 14, 2002 Two General Types of Asbestos Serpentine asbestos (chrysotile) Most commonly
CANCER FACTS N a t i o n a l C a n c e r I n s t i t u t e N a t i o n a l I n s t i t u t e s o f H e a l t h D e p a r t m e n t o f H e a l t h a n d H u m a n S e r v i c e s Asbestos Exposure: Questions
MD, DScMed, FRCP, FRACP, hon. FACP Emeritus Professor and Fellow of the Academy of Science, the Royal Institute of Thailand Abstract Chrysotile, a serpentile asbestos, has been used in a number of Thai
Charité- Universitätsmedizin Berlin Institut für Arbeitsmedizin Prof. Dr. med. X. Baur Prevention, recognition and compensation of asbestosinduced diseases (AD) - Which diseases are asbestos-related? -