1 Master s Degree Program in Clinical and Translational Science Teaching Faculty - Core Courses Angeline Andrew, PhD Assistant Professor, Department of Epidemiology Description: Bi-directional research employing population-based collections of human specimens linked to clinical databases, as well as cell culture models, to 1) identify factors that modify cancer susceptibility, recurrence, progression, and survival, 2) identify host genetic factors that modify response, 3) analyze interactions between multiple stressors, and 4) demonstrate intermediate toxicologic/carcinogenic mechanisms. Teaching at Dartmouth: Faculty member PEMM, QBS, graduate student mentor. Cancer Biology (lecturer), Biostatistics and Epidemiology Core Course (small group leader), SYNERGY Certificate Program (co-director). CTS Masters: Clinical Trials Part 2, Research Tutorial Amar Das, MD, PhD Associate Professor of Psychiatry, Associate Professor The Dartmouth Institute, Research Description: Research and teaching in Biomedical Informatics with a focus on Clinical Research Informatics, Translational Bioinformatics and Population Sciences. Research work includes novel computational methods in Semantic Technologies, Knowledge Acquisition, Temporal Data Mining, Data Visualization, Data Integration, Text Mining and Information Extraction. CTS Masters: Introduction to Clinical Research Informatics James DiRenzo, PhD Associate Professor of Pharmacology & Toxicology Research Description: Genetic control of self-renewal in a progenitor cell population during mammary gland differentiation. Application of the principles of tumor stem cell theory to translational breast cancer research. Teaching at Dartmouth: PEMM 103 CTS Masters: PEMM 131
2 Jennifer A. Doherty, MS, PhD Assistant Professor of Epidemiology; Assistant Professor of Community and Family Medicine Research Description: The Doherty Cancer Epidemiology Laboratory focuses on the molecular and genetic epidemiology of ovarian and lung cancers. Teaching at Dartmouth: CTS Masters: Foundations of Epidemiology Diane Gilbert-Diamond, ScD Assistant Professor, Department of Epidemiology, Geisel School of Medicine. Research Description: Teaching at Dartmouth: CTS Masters: Foundations of Epidemiology Jiang Gui, PhD Assistant Professor, Department of Community and Family Medicine, Director of the Statistical Genomics Laboratory Research Description: Develop cutting-edge biostatistical methods for the analysis of high-dimensional omics data. Recent work has focused on the detection of gene-gene interactions in genome-wide association data. Teaching at Dartmouth: Biostatistics and Epidemiology (CFM104) Department of Community & Family Medicine Dartmouth Medical School, Clinical Biomedical Research (Bio1) Dartmouth College, Advanced Statistical Methods (ECS245) Dartmouth Medical School CTS Masters: PEMM 103 Allan Gulledge, PhD Assistant Professor of Physiology and Neurobiology Research Description: Our research focus is the cerebral cortex, an area of the brain that serves as the biological substrate for the higher cognitive functions that define us as individuals. We wish to identify the mechanisms by which individual cortical neurons process and transmit information within the cortical circuit. To accomplish this we employ electrical and optical recording techniques that measure neuronal activity in individual neocortical neurons under a variety
3 of experimental conditions. Teaching at Dartmouth: PEMM 101, PEMM 211, PEMM 212, PEMM 271, PHSL 110,MDED 115, UNSG 100 CTS Masters: UNSG 100 Lionel D. Lewis, MD, MA Professor of Medicine, Professor of Pharmacology and Toxicology Research Description: Dr. Lewis work has focused on two areas of research at Dartmouth. He is interested in the Phase I development of antineoplastic agents and established the Phase I Oncology Group at Dartmouth where he has studied a number of anti-cancer agents in early clinical development and defined their pharmacokinetic (PK) and pharmacodynamics (PD) and the PK-PD relationships. Dr. Lewis has an ongoing interest in drugs which are toxic to the mitochondrion e.g. anti-hiv nucleosides(azt, ddc and ddi ). CTS Masters: Clinical Investigators Training Institute Course Jon D. Lurie, MD, MS Associate Professor of Medicine, Associate Professor of Orthopaedic Surgery, Associate Professor of The Dartmouth Institute, Director, Clinical Trials Unit, The Dartmouth Institute for Health Policy and Clinical Practice, Co-Director, Center for Translation of Rehabilitation Engineering Advances and Technology, T2-T3 Portal Director, SYNERGY: Dartmouth Center for Clinical and Translational Science. Research Description: Dr Lurie has extensive experience in comparative effectiveness research and pragmatic clinical trials as Physician Investigator on the Spine Patient Outcomes Research Trial (SPORT) and a Co-Investigator on the Multi-Centered Prospective Study of Quality of Life in Adult Scoliosis. He is the Principal Investigator of pragmatic randomized clinical trials of fall prevention in the elderly and decision coaching in lumbar spinal stenosis, and he is Program Lead for Dartmouth-Hitchcock to the High Value Healthcare Collaborative. He serves as primary mentor on a NCCAMfunded K-01 award evaluating the utilization and safety of chiropractic care in older adults using Medicare claims data and as a research mentor in the NH INBRE grant on a project evaluating the reliability of center-of-foot-pressure as a measure of balance and fall risk in older adults. Teaching at Dartmouth: Bio1, SYNERGY Certificate Program small group leader,t2 Surgical Intervention studies, ECS 010, Course Director, ECS 80, Course Director CTS Masters: Clinical Trials Part 1, Research Tutorial
4 Carmen Marsit, PhD Associate Professor, Departments of Pharmacology and Toxicology and Community and Family Medicine Research Description: To investigate gene environment interactions and their individual and combined impact on human disease, with a particular focus on the impact of the environment and lifestyle on the character of the human epigenome. The research has focused on two distinct, yet highly related biologic processes, that of environmental carcinogenesis and that of human development. Teaching at Dartmouth: PEMM 103(Co-director), GENE 110, PEMM 123, QBS 131 CTS Masters: PEMM 103 William North, PhD Professor of Physiology and Neurobiology Research Description: Dr. North s studies are centered on the expression of vasopressin and oxytocin genes, and on the post-translational generation of vasopressin, oxytocin, and neurophysins in hypothalamic neurons, small cell carcinoma cells, and breast cancer cells. Patients with Alzheimer's disease have reduced brain levels of vasopressin, oxytocin, and neurophysins. Vasopressin and its peptide fragments improve short-term memory consolidation and retrieval, while oxytocin functions as an amnesic agent. In tumor cells, vasopressin functions as an autocrine growth factor acting through all three of its receptors. In addition, vasopressin-related proteins are markers for small cell lung cancer and breast cancer. Teaching at Dartmouth: Medical Endocrinology, G.I. Physiology, Biomedical Ethics. CTS Masters: Responsible conduct of Research in Human Subjects Tor D. Tosteson, Sc.D. Professor, Biomedical Data Science, Community and Family Medicine (Biostatistics) and The Dartmouth Institute of Health Policy and Clinical Practice Director, Division of Biostatistics Courses Taught at Dartmouth: QBS 120 Fundamentals of Biostatistics I QBS 121 Fundamentals of Biostatistics II QBS 178 Statistics for Clinical and Translational Research
5 Research Description: Dr. Tosteson s current research interests revolve around challenging methodological and statistical problems in medicine. Applied projects include the Center for Comparative Effectiveness Research in Advanced Imaging in Cancer, the Alternative Breast Cancer Imaging Program, and the Spine Patients Outcomes Research Trial, a multicenter trial of surgery versus nonoperative methods of treating low back pain. He conducts related statistical research in the areas of covariate measurement error for nonlinear regression models and statistical methods for comparative effectiveness research. Teaching at Dartmouth: QBS Fundamentals of Biostatistics I & II CTS Masters: QBS 178 Statistics for Clinical and Translational Research Michael J. Spinella, PhD Associate Professor of Pharmacology and Toxicology Research Description: Molecular Targets of Cancer Therapy Research projects in Dr. Spinella's laboratory are focused on identification of mechanistic links between stem cell pluripotency and cancer and the identification of downstream genes and pathways that are induced during chemotherapy that either kill tumors or in other instances lead to their resistance. Teaching at Dartmouth: Pharm 215; Medical Pharmacology, PEMM 126, Cancer Biology, Pharm 133 Pharmacology of Drug Development, PEMM 131, Current Approaches in Experimental Therapeutics CTS Masters: PHARM 133 Richard J. Barth, MD Associate Professor of Surgery Clinical and Translational Science Research Tutorial Faculty Research Description: Interested in understanding the immune response to tumors in vivo by characterizing the cytokines expressed by lymphocytes infiltrating tumors and the tumors themselves. Now actively investigating the mechanisms underlying this phenomenon, and are trying to exploit this in the generation of more effective vaccines.
6 Stephen J. Bartels, MD Professor of Psychiatry, Professor of Community and Family Medicine, Professor of the Dartmouth Institute Research Description: Geriatric Mental Health Services Research; Health Promotion Research; Illness Self-Management Interventions Implementation Research. Teaching at Dartmouth: MS TDI PGM Konstantin H. Dragnev, MD Professor of Medicine Research Description: Lung cancer, Translational research, Clinical Research Paul E. Holtzheimer, MD Associate Professor of Psychiatry, Associate Professor of Surgery Research Description: Dr. Holtzheimer s research program at Dartmouth is focused on the neurobiology and treatment of mood disorders, primarily treatment-resistant depression. Current methodologies include functional and structural neuroimaging and focal neuromodulation techniques such as transcranial magnetic stimulation and deep brain stimulation. Teaching at Dartmouth: Neuroscience II Barbara C. Jobst, MD Associate Professor of Neurology Research Description: Dr. Jobst and the Epilepsy Center perform translational research in cognitive neuroscience and epilepsy. The research directly translates findings in animal models regarding memory to an experiment in humans utilizing single neuron physiology in patients with epilepsy. Dr. Jobst and the Epilepsy Center also researches comorbidities such as depression and cognitive impairment. Other research includes the characterization of certain types of seizures, outcomes of epilepsy surgery and imaging studies that guide epilepsy surgery. Teaching at Dartmouth: Neu-401, Neu-527, Neu-411 as well as SBM- Neurology
7 Margaret Karagas, Ph.D. Chair and Professor of Epidemiology; Professor of Community and Family Medicine Research Description: To understand the pathogenesis of human disease through population-based approaches, with prevention as the ultimate objective. Teaching at Dartmouth: CFM104, Biostatistics and Epidemiology; ECS151 Occupational and Environmental Health Center for Evaluative Clinical Sciences, Department of Community & Family Medicine; QBS 130 Foundations of Epidemiology I, Theory and Methods, Quantitative Biomedical Sciences Graduate Program; ECS 187/188/198, Directed Readings; ECS 197/198/199, Directed Research; IS 87.1, Essentials of Global Health Research, Dartmouth College; Certificate Course, SYNERGY Alan T. Kono, MD Assistant Professor of Medicine Research Description: Heart failure in a Rural Population and reducing readmissions and improving quality of care. Teaching at Dartmouth: Scientific Basis of Medicine, Cardiology Seminar Leader and Health, Society and Physician, Mentor/Facilitator and Small Group Leader Richard J. Powell, MD Professor of Surgery, Professor of Radiology Research Description: Translational research and clinical trial design. Dr. Powell is currently the national or international Principle Investigator on a Gene Therapy Trial, Stem Cell Therapy Trial, and a lower extremity stent trial. William F.C. Rigby, MD Professor of Medicine, Professor of Microbiology and Immunology
8 Research Description: Dr. Rigby's laboratory integrates his basic scientific and clinical interests. On a translational level, Dr. Rigby is examining immune mechanisms in rheumatoid arthritis as well as the changes that accompany clinical responses in response to therapy. David W. Roberts, MD Professor of Surgery, Professor of Neurology Research Description: Intraoperative guidance systems; intraoperative optical imaging; epilepsy Gary N. Schwartz, MD Associate Professor of Medicine Research Description: Cancer chemotherapy and endocrine therapy for breast cancer, signal transduction pathways in breast cancer, and new drug development. Peter F. Wright, MD Professor of Pediatrics Research Description: Both laboratory interests in mucosal immunity to respiratory and enteric pathogens and interest in global health with a particular emphasis on Haiti Teaching at Dartmouth: Organized Porter Symposium on Dartmouth involvement in Haiti with involvement across the whole Dartmouth community, mentoring of students working internationally, seminars in Microbiology and Immunology. Richard A. Zuckerman, MD, MPH Associate Professor of Medicine, Director, Transplant and Immunocomprised Host Program, Program Director, Infectious Disease Fellowship Research Description: He is involved in translational research of mechanisms to evaluate and improve immune function after transplantation. Specifically, he is involved in the evaluation of biomarkers that correlate with immunologic recovery after organ
9 transplantation with a goal of optimizing clinical outcomes. Additionally, he has research evaluating hematologic predictors of response conjugate vaccine after autologous marrow transplantation.
10 Clinical and Translational Science Elective Courses Faculty Alan Eastman, PhD Professor of Pharmacology and Toxicology Research Description: Research projects in Dr. Eastman s laboratory are focused on preclinical development of novel cancer chemotherapeutic strategies, using novel therapeutic agents often as modulators of the response of established drugs. Teaching at Dartmouth: PEMM 126 CTS Masters: PEMM 126 Bill D. Roebuck, PhD Professor of Pharmacology and Toxicology Research Description: Work in Dr. Roebuck's laboratory is in the area of chemical carcinogenesis and cancer chemoprevention. He conducts experiments in two different models of cancer, namely, the rat/aflatoxin model for liver cancer. The common theme of his studies is the modulation of cancer development by nutritional factors or chemicals that would or could be added to the diet of animals including humans. Teaching at Dartmouth: PEMM 123, ENVS 28, ENVS 40 CTS Masters: PEMM 123 Joseph M. Rosen, MD Professor of Surgery, Adjunct Professor of Engineering and Senior Lecturer Research Description: Nerve repair and human machine interfaces; microsurgery and transplantation of limbs; computer-aided surgery; virtual reality simulators and methods of education; telemedicine and informatics; healthcare delivery for medical disasters and counter measures for bio-terrorism. Teaching at Dartmouth: ENG S 5 CTS Masters: ENG S 5
11 Radu V. Stan, MD Associate Professor of Pathology, Associate Professor of Microbiology and Immunology Research Description: Dr. Stan s laboratory is focused on how vascular endothelial cells control the exchange of solutes and cells between the blood and tissues. Teaching at Dartmouth: PEMM 275 CTS Masters: PEMM 275 Edward J. Usherwood, PhD Associate Professor of Microbiology and Immunology Research Description: Dr. Usherwood studies the generation and maintenance of T cell memory. T cells recognized and destroy cells infected with intracellular pathogens such as viruses and are also important in protection against tumor development. Teaching at Dartmouth: MICR146 CTS Masters: MICR 146 Michael L. Whitfield, PhD Associate Professor of Genetics Research Description: Dr. Whitfield is interested In the regulatory mechanisms governing gene expression and in the cell biology of the human cell division cycle and the systemic autoimmune disease, scleroderma. His laboratory will pursue functional studies of novel genes identified in our genome-wide analyses in order to better understand the cell biology of these systems; antibodies have been raised against >70 novel cell cycle-regulated genes and will form the basis of initial studies. Teaching at Dartmouth: CTS Masters: GENE 146