Course Drugs of Abuse

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1 Lecture Objective Template Curse Drugs f Abuse PHAR 4207 Spring 2015 Lecture #1 Date/time: 2/15/2015 Terminlgy f Drugs f Abuse Define cmmn terms assciate with drug abuse. Give examples f variables affecting the nset and cntinuatin f drug abuse. Understand the majr reward circuitry in the brain assciated with substance abuse Lecture #2 2/16/2015 Histrical Perspectives f Drugs f Abuse Describe the majr evlutin f American drug plicy with respect t alchl, pium, ccaine, and marijuana. Be familiar with the time perid f majr US drug plicies. Understand the rganizatin and creatin f federal gvernmental agencies such as the Federal Bureau f Narctics, Drug Enfrcement Agency and Natinal Institute f Drug Abuse. Lecture #3 2/17/2015 Nictine and Cigarette Smking Describe the histry and basic epidemilgy f cigarette smking rates in the US fr different grups. Understand the majr health cnsequences f cigarette smking. Knw the neurchemistry and pharmackinetics f nictine and hw these cntribute t abuse liability. List the majr nictine withdrawal symptms. Understand sme cmmn replacement and adjunct therapy fr smking cessatin. 1

2 Lecture #4 2/18/2015 Prescriptin Drug Abuse Determine abuse trends in classes f Rx drug abuse. Define abuse, misuse and pseudaddictin Understand Rx drug abuse trends in rural vs. urban cmmunities Knw the different methds used t tamper with Rx piids. Lecture #5 2/22/2015 Opiid Drug Abuse Describe the endgenus piid system (receptrs, natural and synthetic ligands). Describe the physilgic effects and cellular mechanisms f actin fr piates. Understand the behaviral and neurchemical mechanism fr piate tlerance and dependence. Understand the therapeutic ptins fr piate addictin and txicity. Lecture #6 3/23/2015 Alchlics Annymus/Narctics Annymus and Family Dynamics Explain the histry and cncepts f Alchlics/Narctics Annymus. Describe the cmpsitin f AA. Differentiate the main distinctin between AA and NA. Understand the utility f the Making Alchlics Annymus Easier (MAAEZ) apprach. Describe dysfunctinal family patterns and specific effects n family life. Explain steretypical behavirs and defense mechanism perative in family members f substance abusers. Lecture #7 2/24/2015 Epidemilgy & Cultural Perspectives f Drug Abuse Summarize general tenets f glbal drug abuse. Rank the mst cmmnly abused illicit drugs in the U.S. Summarize the patterns f drug abuse in the U.S. including peak age, lcatin, and 1st drugs f abuse. List thse states with the highest incidence f drug abuse in the U.S. 2

3 Summarize trends f majr drugs f abuse in Texas and list the regin f Texas with the highest incidence f drug and alchl abuse. Rank the mst cmmn racial/ethnic grups in the U.S. that abuse illicit drugs, alchl, and tbacc. List the racial/ethnic grups in Texas and their mst cmmn agents f abuse. Lecture #8 2/25/2015 Drug Abuse Amng Health Care Prfessinals & Impairment List several factrs why health care prfessinals are at risk fr drug abuse. Cmpare and cntrast the different types f drug abuse amng varius health care prfessinals. Define health care prfessinal impairment. Identify the hallmark signs f impairment in health care prfessinals. Summarize the rle f the PRN in Texas including funding, lcatin, health care prfessinals cvered, and cntact infrmatin. Summarize the ASHP psitin statement n the pharmacist s rle in substance abuse preventin, educatin, and assistance. Lecture #9 2/29/2015 Cannabis List cmmn street names fr marijuana. Summarize the abuse patterns f marijuana wrldwide, in the U.S., and in Texas. Summarize the pharmackinetics f THC and evaluate urine drug screen results with histry in a patient using marijuana. Review the effects f THC n the brain and hw it relates t clinical symptms seen. Summarize the clinical symptms f marijuana use. Outline the effects f marijuana n driving and hw these effects change in the face f alchl. Summarize legality f marijuana in the U.S. especially in States like Clrad & Washingtn. Lecture #10 3/1/2015 Cannabis & Alchl Case Study Mck Trial See lecture bjectives fr lecture 16. Lecture #11 3

4 3/2/2015 Inhalants List and categrize inhalants int their fur main types. Summarize the prevalence f inhalant abuse in the U.S. and Texas. Summarize and demnstrate the different ways inhalants are used. Summarize the acute and chrnic effects f inhalant abuse including ther medical cnsequences. Recgnize the hallmarks f inhalant abuse. Summarize nitrite abuse and hw it mechanistically differs frm ther inhalants. Lecture #12 3/3/2015 Ccaine Cmpare and cntrast ccaine HCl and freebase ccaine. Summarize ccaine prductin, traffic and wrldwide abuse. Summarize ccaine abuse in the U.S. and Texas. Cmpare and cntrast ccaine s nset f actin, peak actin, and duratin f actin depending n rute f administratin. Summarize ccaine s metablism and hw it relates t urine drug screens. Summarize ccaine s pharmaclgy and hw it relates t acute and chrnic clinical effects. List substances cmmnly invlved in bdy packing/stuffing. Outline treatment ptins in smene suspected f bdy packing. Cnstruct a ratinal treatment apprach t a patient presenting with ccaine verdse. Lecture #13 3/7/2015 Methamphetamine List cmmn street names fr methamphetamine. List five (5) cmmn husehld ingredients used t make methamphetamine. Summarize the wrldwide seizures and use f methamphetamine. Summarize the U.S. & Texas use f methamphetamine including deaths, purity and preferred rutes f administratin. Cmpare and cntrast ccaine and methamphetamine s rigin, pharmaclgic effects, duratin f actin, and clinical effects. Summarize methamphetamine s shrt- and lng-term clinical effects. Summarize State and Federal laws regarding prducts cntaining pseudephedrine. Lecture #14 4

5 3/8/2015 Club Drugs List ppular street names fr GHB & flunitrazepam. Cmpare & cntrast the pharmackinetics f GHB & flunitrazepam. Summarize hw the club drugs GHB & flunitrazepam are used and abused. Differentiate hw GHB & flunitrazepam cause their effects n the brain. Summarize the clinical effects f GHB & flunitrazepam including withdrawal syndrmes. Lecture #15 3/9/2015 Alchl I Yu shuld be able t Discuss: The diagnstic criteria fr alchl abuse and alchl dependence. Cmpare and cntrast alchl abuse vs. alchl dependence. Yu shuld be able t Discuss: Characteristics & epidemilgy f alchl abuse disrders Adverse cnsequences f alchl abuse The physilgy behind alchl addictin Hw t screen patients fr alchl abuse List psychscial treatment fr thse wh abuse alchl Lecture #16 3/10/2015 Alchl II Yu shuld be able t Discuss: The differences amng mderate, heavy and binge drinking The difference between intxicatin and withdrawal symptms The Pharmaclgy and Pharmackinetics f ETOH Overall Principles f Treatment When t hspitalize Signs and symptms f withdrawal Drug therapy fr acute withdrawal Drug therapy fr maintaining abstinence Lecture #17 3/14/2015 Hallucingens 5

6 Yu shuld be able t: List the mst cmmn hallucingens used Discuss the epidemilgy f hallucingen abuse/use Discuss the pharmaclgy f hallucingenic cmpunds Describe the clinical features f intxicatin Lecture #18 3/15/2015 Inpatient Pain Management and Addictin Apprpriately assess a patient in pain Given a patient in pain, derive a basic treatment plan fr a patient List c-analgesic medicatins cmmnly used t treat pain Write an IV PCA rder fr a patient in the hspital Transitin a patient frm IV pain therapy t a hme regimen Treat a patient in pain that has either cancer pain, sickle cell disease r pst-perative pain Lecture #19 3/16/2015 Outpatient Pain Management and Addictin Define: Chrnic pain (als classify pain syndrmes) Dependence Addictin Pseudaddictin Tlerance Identify behavirs f inapprpriate piid use by patients Discuss appraching patients with pain abut substance abuse prblems Outline prvider cncerns and barriers t effective pain management in patients with substance abuse disrder Develp a treatment plan fr pain in a patient with a substance abuse disrder Describe a pain cntract Lecture #20 3/17/2015 Substance Abuse and Mental Illness Yu shuld be able t Discuss: The cncept f dual diagnsis The epidemilgy f dual diagnsis patients 6

7 The diagnsis f dual diagnsis patients Substance abuse and psychpathlgy Clinical challenges General Treatment Strategies Pharmactherapy 7

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