From metabiobanks to translational research platforms: Integrating Big Data through CRIP Tools

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1 From metabiobanks to translational research platforms: Integrating Big Data through CRIP Tools 4 th Munich Biomarker Conference, November 26, 2014

2 Access to goods Leipzig Trade Fair Quelle Versandhaus dpa We seek to be Earth s most customer-centric company for four primary customer sets: consumers, sellers, enterprises, and content t creators. and to biomedical research-related information ? Fraunhofer ISST 2011

3

4 Metabiobanks / CSMPs Demonstrators: Whitepaper: logiefelder/cloudcomputing/fraunhofer-isst_csmp- ld dc i /F f CSMP Whitepaper_www.pdf P-BioSPRE https://preview-crip.fraunhofer.de/intern/demo/searchtool/search/p- i h f /i t /d / h/ biospre.cgi Weiler G, Schröder C et al.: p-biospre An ICT Framework for Transnational Biomaterial i Sharing and Access ecancer 2014, 8:401 (www.ecancer.org) DPKK-Biobank https://preview-crip.fraunhofer.de/intern/demo/dpkk User: user PW : dpkk

5 CRIP Privacy Regime Research Pool 1 FallgPool Fal 2 3 Pool PFallg4pe 4 3) Statistical Groups Metabiobank 2) Anonymize Search Profile Partner 1 IRDB Biobank Partner 2 IRDB 1) Pseudonymize Biobank C. Schröder C, Heidtke KR, Zacherl N, Zatloukal K, Taupitz J: Safeguarding donors' personal rights and biobank autonomy in biobank networks: the CRIP privacy regime. Cell Tissue Bank 12 (2011), pdf

6 Features of our metabiobanks Web-based parameterized queries (case-by-case) across the entire spectrum of diseases on anonymized data only: Privacy preserving Fulfill BBMRI requirements for networked ICT infrastructure Utilize all pre-existing information management systems No ICT skills required Semi-automated / controlled data export Project request: Establish Biobanking on demand?

7 Biobank Partners Biobank Data Transfer Agreements with Charité Universitätsmedizin Berlin Medizinische Universität Graz Klinikum Rechts der Isar / TU München Universitätsklinikum Ulm Zentralinstitut für Seelische Gesundheit, Mannheim Norddeutsches Darmkrebsnetzwerk / UKSH Lübeck Kinderonkologie und PopGen, UKSH Kiel Kompetenznetz HIV/AIDS, Bochum / Köln Universitätsklinikum des Saarlandes, Homburg Deutsches Prostatakarzinom-Konsortium, Düsseldorf, CRIP website coupled over web services with biobank-suisse

8 CRIP Toolbox Free text records Import Pseudonymised Data div. Formats Anonymisation Export Harmonisation www: Pools Hospital Biobank Project request

9 Free text records Generic, structured data (ICD, TNM...) Import of Coding Guide (e.g. ICD) no training set and no manual entry of rules required Negations interpreted correctly Quick-and-easy amendment of dictionaries and rules multiple languages under clinical evaluation with Inst. of Pathology, Univ. Bern Hospi- tal Biobank

10 .IDB Free text records Import Pseudonymised Data div. Formats Harmonisation Anonymisation Export Hospi- tal Biobank

11 .IDB Harmonize data Checking of data (text, value, date) Catalog values, calculation of values, regular expressions Pre-processing (prior to data import) Analysis of errors Mapping of parameters Anonymize data No tracing back, no reference list Singular random codes Control data export Review export files; no hidden data transfer Metadata repository Adopt biobank partner s needs without programming efforts Plug-in external data sources

12 Data source: ivd platform Multimarker Lab-On-a-Chip System (up to 500 parameters / test) Pluggable into existing CRIP architecture t and tools Standards-compliant (CDISC, HL7, LOINC, POCT1-A) Reader unit Cardiac biomarkers Cartridge plattform.fraunhofer.de/

13 Scientific community BETRIEBEN DURCH DPKK Members / biobanks

14 Funktionalities DPKK-Biobank Integrate Access Navigate Unite Stratify

15 Role Model CRIP.IANUS / DPKK-Biobank P2B2 User Scientific community Admin Web-based based query tool (members only) Webservice API Members only... o y User Anonymised cases / samples Export Project requests Metadata Data Import Biobank operators: Anonymised cases/samples Institute

16 .Anon Configure and document data anonymization De-Identification: Identifiers replaced by anonymized brackets brackets......and / or k-anonymized through Report: Time stamp De-Identifiers: Name(s), status, file K-Anon: Report file Anonymisation Export Hospi- tal Biobank

17 CRIP Search tool Dynamic generation of query interface Corporate design Export www: Pools Hospi- tal Biobank Project request

18 Technologies Server infrastructure: Linux, Apache, PosgreSQL Web Standards (HTML, XML, XSL, CSS, Javascript) Open standards and technologies Programming platform: Perl, Webservices, jquery

19 Big Data Velocity Variety Variability Volume Enhance performance: CRIP.IndexIndex Integrate Diagnoses: ICD, SNOMED, disease ontology.. Restrict Minimal Dataset to a minimum! Molecular biology / Omics data Process multi-parameter analyses (ivd platform) g

20 Thank you! Matthias Dobkowicz, Rukeia El- Athman, Thomas Finkenwirth, Harry Freitas da Cruz, Oliver Gros, Karsten R. Heidtke, Tim Jüttner, Sascha Kunze

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