Translational Research in Oncology: a New Approach to Personalized Medicine

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1 P R O G R A M 2 nd International Conference Translational Research in Oncology: a New Approach to Personalized Medicine May 8, 2012 IRCCS IRST, Meldola May , 2012 Hotel Globus City, Forlì

2 Under the Auspices of: Alto Patronato del Presidente della Repubblica Italiana Ministero della Salute Ministero dell Istruzione, dell Università e della Ricerca Regione Emilia Romagna Provincia Forlì-Cesena Comune di Forlì Ordine dei Medici e Odontoiatri Forlì-Cesena Azienda Unità Sanitaria Locale di Forlì AIOM, Associazione Italiana di Oncologia Medica AIRO, Associazione Italiana di Radioterapia Oncologica ESMO, European Society for Medical Oncology FISM, Federazione delle Società Medico-Scientifiche Italiane IOR, Istituto Oncologico Romagnolo ISO, Società Italiana di Osteoncologia LILT, Lega Italiana per la Lotta contro i Tumori SIC, Società Italiana di Cancerologia SIE, Società Italiana di Ematologia

3 Presidents Dino Amadori Rosella Silvestrini Scientific Committee Giovanni Luca Frassineti Giorgio Cruciani Ugo De Giorgi Muller Fabbri Pier Paolo Fattori Giampaolo Gavelli Toni Ibrahim Carlo Milandri Oriana Nanni Giovanni Paganelli Rolando Polico Alberto Ravaioli Ruggero Ridolfi Andrea Rocca Wainer Zoli Organizing Committee Carlo Milandri Salvatore Luca Burgio Alberto Farolfi Andrea Casadei Gardini Talia Piolanti Marianna Ricci Gráinne Tierney Martina Valgiusti Annalisa Volpi Scientific Secretariat IRCCS Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IRST) Via Maroncelli, Meldola (FC), Italy Ph Organizing Secretariat Studio E.R. Congressi - Triumph Group Via Marconi, Bologna, Italy Ph Fax

4 FACULTY Matti S. Aapro Genolier, Switzerland Adriana Albini Milano, Italy Dino Amadori Meldola (FC), Italy Andrea Ardizzoni Parma, Italy Paolo A. Ascierto Napoli, Italy Domenico Barone Meldola (FC), Italy Mirco Bartolomei Cesena, Italy Massimo Bellomi Milano, Italy Marcello Benassi Meldola (FC), Italy Giampaolo Biti Firenze, Italy Sergio Bracarda Arezzo, Italy Paolo Bruzzi Genova, Italy George A. Calin Houston, USA Stefano Cascinu Ancona, Italy Ian Chau London, United Kindom Rita Chiari Perugia, Italy Pierfranco Conte Modena, Italy Massimo Cristofanilli Philadelphia, USA Carlo M. Croce Columbus, USA Giorgio Cruciani Ravenna, Italy Riccardo Dalla Favera New York, USA Romano Danesi Pisa, Italy Serena Di Cosimo Milano, Italy Ugo De Giorgi Meldola (FC), Italy Antonio Esposito Milano, Italy Muller Fabbri Meldola (FC), Italy - Columbus, USA Pier Paolo Fattori Meldola (FC), Italy Roberto Foà Roma, Italy Silvia C. Formenti New York, USA G. Luca Frassineti Meldola (FC), Italy Gianluca Gaidano Novara, Italy Ramiro Garzon Columbus, USA Giampaolo Gavelli Meldola (FC), Italy Emanuele Giordano Bologna, Italy Grazia Graziani Roma, Italy Toni Ibrahim Meldola (FC), Italy Yibin Kang Princeton, USA Claus-Henning Köhne Oldenburg, Germany Barbara Kopf Meldola (FC), Italy Eunice L. Kwak Boston, USA 4 4

5 FACULTY Roberto Labianca Bergamo, Italy James Larkin London, United Kindom Michele Maio Siena, Italy Giovanni Mandoliti Rovigo, Italy Francesco M. Marincola Bethesda, USA Massimo Massaia Torino, Italy Laura Mercatali Meldola (FC), Italy Carlo Milandri Empoli, Italy Alessandro Morabito Napoli, Italy Dario Neri Zürich, Switzerland Giovanni Paganelli Milano, Italy Angelo Paradiso Bari, Italy Fabrizio Pane Napoli, Italy Pier Giuseppe Pelicci Milano, Italy Edith Perez Jacksonville, USA Sandro Pignata Napoli, Italy Rolando Polico Meldola (FC), Italy Paolo Pronzato Genova, Italy Alberto Ravaioli Rimini, Italy Federico Rea Padova, Italy Ruggero Ridolfi Meldola (FC), Italy Andrea Rocca Meldola (FC), Italy Roberto Sabbatini Modena, Italy Giuseppe Saglio Orbassano (TO), Italy Leonardo Santi Genova, Italy Anna Sarnelli Meldola (FC), Italy Giorgio V. Scagliotti Torino, Italy Manuela Schmidinger Wien, Austria Gianluca Severi Carlton, Australia Stefano Severi Meldola (FC), Italy Rosella Silvestrini Meldola (FC), Italy Alberto Sobrero Genova, Italy Cora Sternberg Roma, Italy Stefano Tamberi Faenza (RA), Italy Ayalew Tefferi Rochester, USA Anna Tesei Meldola (FC), Italy Gabri van der Pluijm Leiden, The Netherlands Augusto Villanueva Barcelona, Spain Jeffrey Weber Tampa, USA Kurt Zatloukal Graz, Austria Pier Luigi Zinzani Bologna, Italy 5 5

6 PROGRAM Tuesday May 8, 2012 IRCCS IRST, Meldola 2.30 p.m. Welcome Ceremony D. Amadori, Scientific Director IRCCS IRST R. Silvestrini, Scientific Consultant IRCCS IRST AIOM President S. Cascinu In memory of Marco Venturini AIRO President G. Mandoliti ISO President T. Ibrahim SIE President F. Pane President: L. Santi Chairmen: A. Paradiso, A. Ravaioli 3.30 p.m. Lecture Clinical traslational research in oncology: trials methodology and new developments P. Bruzzi 4.00 p.m. Lecture Circulating Tumor Cells: preclinical data and clinical impact M. Cristofanilli 4.30 p.m. Lecture Mammary epithelial lineage determinants in mammary gland development, breast cancer initiation and metastasis Y. Kang 5.00 p.m. Lecture Epidemiological research in the whole-genome era: challenges and opportunities G. Severi 5.30 p.m. Lecture Bioengineering as a tool for translational research in oncology E. Giordano 6.00 p.m. Opening Ceremony with the Italian Minister of Health 7.00 p.m. Visit of the Institute 7.30 p.m. Cocktail 6 6

7 PROGRAM Wednesday May 9, 2012 Hotel Globus City, Forlì 8.30 a.m. Lecture The role of biobanking in personalized medicine K. Zatloukal Breast President: A. Rocca Chairmen: G. Cruciani, P. Pronzato 9.00 a.m. Targeting breast cancer stem cells P.G. Pelicci 9.25 a.m. Targeting the PI3K/Akt/mTOR pathway in breast cancer S. Di Cosimo 9.50 a.m. New therapeutic opportunities in HER2-positive tumors E. Perez a.m. Coffee break a.m. Synthetic lethal approaches: PARP inhibitors G. Graziani a.m. Anti-angiogenic therapies in breast cancer R. Danesi a.m. New therapeutic opportunities in breast cancer: from liposomal to nanotechnological formulations P. Pronzato a.m. The role of microenvironment in breast cancer development and progression A. Albini p.m. Discussion 7 7

8 PROGRAM Radiometabolic Medicine President: G. Paganelli Chairmen: M. Bartolomei, S. Severi p.m. Monoclonal antibody small immunoprotein (SIP) tumor targeting in patients with cancer D. Neri 1.10 p.m. Poster Session and Buffet Lunch Chairmen: G.L. Frassineti, W. Zoli P01 Fenretinide: new perspectives in treatment of medulloblastoma Bartolini D., Magnani E., Pagani A., Focaccetti C., Cantelmo A.R., Albini A. Fondazione MultiMedica Onlus, Science and Technology Pole, Milan; IRCCS MultiMedica, Milan, Italy P02 Isolation of living circulating tumor cells using the DEPArray TM platform Carloni S., Fanini F., Gallerani G., Bandini E., Pignatta S., Fabbri F., Brigliadori G., Amadori D., Zoli W. Biosciences Laboratory, IRCCS Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IRST), Meldola (FC), Italy P03 I.R.S.T. s surveillance of therapeutic use of investigational medicinal product s under Italian Ministerial Decree 8 May 2003 (D.M. 08/05/2003): possible tool to generate translational research s hypothesis Donati C., Burioli P., Benini G., Minguzzi M. Clinical Oncological Pharmacy and Ethics Committee s (CEAV/IRST), Scientific Secretariat of IRCCS Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IRST), Meldola (FC), Italy P04 Investigation of circulating colon and lung cancer cells using dielectrophoresis-based instrumentation Fabbri F., Carloni S., Ulivi P., Gallerani G., Fici P., Chiadini E., Amadori D., Zoli W. Biosciences Laboratory, IRCCS Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IRST), Meldola (FC), Italy P05 BRAF gene mutation and MLH1 promoter methylation in colorectal carcinomas with microsatellite instability and loss of MLH1 protein expression Gafà R., Maestri I., Ulazzi L., Mazzoni R., Mora F., Magri E., Zampini C., Lanza G. Section of Anatomic Pathology, Department of Experimental and Diagnostic Medicine, University of Ferrara, Ferrara, Italy 8 8

9 P06 Developing of an in vitro model of breast cancer osteolytic bone metastasis for preclinical trials of novel bone-targeted molecules Liverani C., Ibrahim T., Mercatali L., Zoli W., Amadori D. Osteoncology Center, IRCCS Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IRST), Meldola (FC), Italy P07 Phosphorylated Akt and MAPK expression in primary tumours and in corresponding metastases and clinical outcome in colorectal cancer patients receiving irinotecancetuximab Loretelli C., Giampieri R., Scartozzi M., Maccaroni E., Mandolesi A., Biagetti S., Alfonsi S., Giustizi L., Faloppi L., Bittoni A., Bianconi M., Del Prete M., Bearzi I., Cascinu S. Clinica di Oncologia Medica, AO Ospedali Riuniti-Università Politecnica delle Marche, Ancona, Italy; Scuola di Specializzazione in Oncologia, Università Politecnica delle Marche, Ancona, Italy; Anatomia Patologica, Università Politecnica delle Marche, Ancona, Italy; Oncologia Medica, Ospedale di Fermo, Fermo, Italy P08 Highly sensitive FRET biosensors for detecting MT1-MMP activity in live breast cancer cells Lu S., Wang Y., Huang H., Wang Y., Pan Y., Strongin A.Y., Chaney E., Boppart S.A., Ozer H. University of Illinois Cancer Center, Chicago, USA P09 Molecular characterization of breast cancer cell lines after zoledronic acid treatment Mercatali L., Ibrahim T.,Liverani C., Guerra D., Zoli W., Amadori D. Osteoncology Center, IRCCS Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IRST), Meldola (FC), Italy P10 Mini-gene profiling for the prediction of metastatization to bone in breast cancer patients Mercatali L., Ibrahim T., Liverani C., Guerra D., Scarpi E., Zoli W., Amadori D. Osteoncology Center, IRCCS Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IRST), Meldola (FC), Italy P11 Osteoncology Center: the management of patients with bone cancer disease in a multidisciplinary approach Nicoletti S., Ibrahim T., Ricci M., Ricci R., Fabbri L., Falasconi M.C., Casadei R., Micheletti S., Oboldi D., Severi S., Amadori E., Galassi R., Matteucci F., Moretti A., Sansovini M., Petrella E., Ceccolini M., Gavelli G.P., Riva N., Calpona S., Mercatali L., Liverani C., Serra P., Monti M., Maltoni M., Amadori D. Osteoncology Center, IRCCS Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IRST), Meldola (FC), Italy 9 9

10 PROGRAM P12 MicroRNA profile in osteosarcoma: role of mir-1 and mir-133b Novello C., Pazzaglia L., Cingolani C., Conti A., Quattrini I., Manara M.C., Picci P., Benassi M.S. Laboratory of Experimental Oncology, Istituto Ortopedico Rizzoli, Bologna, Italy P13 Circulating RANK/RANK-L/OPG pathway in cancer patients treated with Zoledronic Acid Ricci M., Ibrahim T., Mercatali L., Scarpi E., Fabbri F., Liverani C., Serra P., Ricci R., Nicoletti S., Zoli W., Amadori D. Osteoncology Center, IRCCS Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IRST), Meldola (FC), Italy P14 The role of Research Nurse in the management of bone cancer patients in the multidisciplinary Osteoncology Center (CDO) Ricci R., Ibrahim T., Zavoiu V., Resta D., Tedaldi R., Mercatali L., Nicoletti S., Amadori D. Osteoncology Center, IRCCS Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IRST), Meldola (FC), Italy P15 Circulating tumour cells from bench to bed: streamlining from technological research to clinical practice Torchio M., Danova M., Mazzini G. S.C. Medicina Interna e Oncologia Medica, A.O. di Pavia, Ospedale di Vigevano, Italy; Istituto di Genetica Molecolare GM-CNR, Pavia, Italy P16 EGFR and K-RAS analysis in cytological specimens from Non Small Cell Lung Cancer (NSCLC) patients Ulivi P., Zoli W., Chiadini E., Capelli L., Candoli P., Calistri D., Silvestrini R., Puccetti M. Biosciences Laboratory, IRCCS Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IRST), Meldola (FC), Italy; Pneumology Unit, Lugo Hospital, Lugo, Italy; Pathology Unit, S. Maria delle Croci Hospital, Ravenna, Italy P17 Multiple marker detection in peripheral blood for NSCLC diagnosis Ulivi P., Mercatali L., Casoni G.L., Scarpi E., Bucchi L., Silvestrini R., Sanna S., Monteverde M., Zoli W., Poletti V., Amadori D. IRCCS Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IRST), Meldola (FC), Italy; Interventional Pulmonology and General Thoracic Surgery, Department of Thoracic Diseases, Morgagni-Pierantoni Hospital, Forlì, Italy 10 10

11 PROGRAM Osteoncology President: P. Conte Chairmen: T. Ibrahim, L. Mercatali 2.30 p.m. Lecture Novel mediators of tumor-stromal interactions in bone metastasis Y. Kang 3.00 p.m. Osteoclast-dependent and -independent effects of RANKL inhibition on tumorogenesis and metastasis G. van der Pluijm 3.25 p.m. Beyond the bone: multitarget approach with zoledronic acid M. Massaia 3.50 p.m. Prevention of bone metastases: clinical data M.S. Aapro 4.15 p.m. Discussion mirna President: M. Fabbri Chairmen: G.A. Calin, C.M. Croce 4.30 p.m. Lecture Causes and consequences of mirna deregulation in cancer C.M. Croce 5.00 p.m. micrornas in hematological malignancies R. Garzon 5.25 p.m. micrornas in solid tumors M. Fabbri 11 11

12 PROGRAM 5.50 p.m. Non-coding RNAs and cancer: beyond micrornas G.A. Calin 6.15 p.m. Discussion Thursday May 10, 2012 Hotel Globus City, Forlì Gastrointestinal tract and liver President: G.L. Frassineti Chairmen: S. Cascinu, R. Labianca 9.00 a.m. Lecture Current and emerging therapies for metastatic colorectal cancer A. Sobrero 9.30 a.m. Adjuvant chemotherapy and targeted therapies for resected colon cancer. What next? C.H. Köhne 9.55 a.m. Advanced gastric cancer: the role of target therapy I. Chau a.m. Linking signalling pathways and molecular therapies in hepatocellular carcinoma A. Villanueva a.m. Discussion a.m. Coffee break Hematology President: P.P. Fattori Chairmen: R. Foà, P.L. Zinzani a.m. Lecture Analysis of the genome of Diffuse Large B-cell Lymphoma: pathogenetic and clinical implications R. Dalla Favera 12 12

13 PROGRAM p.m. Targeting JAK in myeloproliferative neoplasms A. Tefferi p.m. Tyrosine kinase pathways in hematologic disorders G. Saglio p.m. Chemorefractoriness in B cell Malignancies: Who and Why G. Gaidano 1.15 p.m. Discussion 1.30 p.m. Poster Session and Buffet Lunch Chairmen: G.L. Frassineti, W. Zoli P18 Slug silencing increases radiosensitivity of melanoma cells in vitro Arienti C., Tesei A., Carloni S., Ulivi P., Romeo A., Ghigi G., Menghi E., Sarnelli A., Parisi E., Silvestrini R., Zoli W. Biosciences Laboratory, IRCCS Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IRST), Meldola (FC), Italy; Radiotherapy Department, IRCCS Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IRST), Meldola (FC), Italy; Department of Health Physics, IRCCS Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IRST), Meldola (FC), Italy P19 Cancer region detection by visual features in histopathology Bevilacqua A., Gherardi A., Busa C., Bravaccini S. DEIS, Department of Electronics, Computer Science and Systems, University of Bologna, Italy; ARCES, Advanced Research Center on Electronic Systems, University of Bologna, Italy; IRCCS Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IRST), Meldola (FC), Italy P20 Extension of the microscope s depth of focus Bevilacqua A., Zoli W., Piccinini F., Tesei A. DEIS, Department of Electronics, Computer Science and Systems, University of Bologna, Italy; ARCES, Advanced Research Center on Electronic Systems, University of Bologna, Italy; IRCCS Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IRST), Meldola (FC), Italy P21 Assessing reliability in computation of perfusion CT indexes Bevilacqua A., Barone D., Carozza L., Gavelli G. DEIS, Department of Electronics, Computer Science and Systems, University of Bologna, Italy; ARCES, Advanced Research Center on Electronic Systems, University of Bologna, Italy; IRCCS Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IRST), Meldola (FC), Italy 13 13

14 PROGRAM P22 Detecting early errors in DCE-CT imaging Bevilacqua A., Barone D., Carozza L., Gavelli G. DEIS, Department of Electronics, Computer Science and Systems, University of Bologna, Italy; ARCES, Advanced Research Center on Electronic Systems, University of Bologna, Italy; IRCCS Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IRST), Meldola (FC), Italy P23 Role of telomerase activity in predicting the clinical outcome of patients with benign lesions of the uterine cervix or CIN Bravaccini S., Amadori A., Scarpi E., Tumedei M.M., Puccetti M., Zoli W., Silvestrini R. IRCCS Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IRST), Meldola (FC), Italy; Department of Obstetrics and Gynecology, Morgagni-Pierantoni Hospital, Forlì, Italy P24 Feasibility study of translational research in Africa: preliminary data on the biology of 71 breast cancer cases from Bugando Medical Center Bravaccini S., Serra P., Tumedei M.M., Puccetti M., Rengucci C., Masalu N., Zoli W., Crinò L., Puglisi F., Franciosi V., Serra L., Amadori D. IRCCS Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IRST), Meldola (FC), Italy; Bugando Medical Center, Mwanza, Tanzania; Medical Oncology Department, S. Maria della Misericordia Hospital, Perugia, Italy; Department of Oncology, University Hospital of Udine, Udine, Italy; Medical Oncology Unit, University-Hospital of Parma, Parma, Italy; Pathology Unit, Morgagni-Pierantoni Hospital, Forlì, Italy P25 Protective effect of Rosiglitazone on late pulmonary damage and radiation-induced acute intestinal damage on a murine model Cassani S., Mangoni M., Franzese C., Masoni T., Loi M., Gerini C., Sottili M., Vanzi E., Pupi A., Livi L., Biti G.P. Clinical Physiopathology Department, University of Florence, Firenze, Italy P26 Prognostic value of proliferation marker Ki67 in advanced breast cancer Farolfi A., Ibrahim T., Mercatali L., Scarpi E., Ricci R., Ricci M., Liverani C., Guerra D., Serra P., Nanni O., Amadori D. Osteoncology Center, IRCCS Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IRST), Meldola (FC), Italy P27 Hormone receptor, Her-2 and Ki67 discordance between primary breast cancer and paired metastases: clinical impact Farolfi A., Ibrahim T., Mercatali L., Scarpi E., Ricci R., Ricci M., Liverani C., Guerra D., Serra P., Nanni O., Amadori D

15 PROGRAM Osteoncology Center, IRCCS Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IRST), Meldola (FC), Italy P28 Local antitumor immune responses in tumor tissues after vaccination with dendritic cell (DC) vaccine in patients with advanced melanoma Granato A.M., Ancarani V., Petrini M., Fiammenghi L., Pancisi E., Ridolfi L., Nicoletti S., Serra L., Lanza G., Verdecchia G.M., Riccobon A., Amadori D., Ridolfi R., Guidoboni M. Immunotherapy, Department of Medical Oncology, IRCCS Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IRST) (FC) Italy; Department of Pathology, Oncological Surgery, Morgagni- Pierantoni Hospital, Forlì, Italy; Department of Pathology, Ferrara University, Ferrara, Italy P29 The Abs.I.De. (Abscopal Effect, Interferon-alpha, Dendritic Cell Vaccine) study: a randomized phase II Proof of Concept clinical study in Advanced Melanoma Guidoboni M., Ridolfi L., Nicoletti S.L.V., Petrini M., Fiammenghi L., Granato A.M., Ancarani V., Pancisi E., Soldati V., Valmorri L., Imbalzano S., Nanni O., Polico R., Amadori D., Riccobon A., Ridolfi R. Immunotherapy, Unit of Biostatistics and Clinical Trials, Radiotherapy and Department of Medical Oncology, IRCCS Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IRST), Meldola (FC), Italy P30 Antitumor activity of Zoledronic Acid in combination with Cisplatin in triple negative breast cancer cell lines Liverani C., Ibrahim T., Mercatali L., Ciani S., Fabbri F., Zanoni M., Zoli W., Amadori D. Osteoncology Center, IRCCS Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IRST), Meldola (FC), Italy P31 Specific biomarkers are associated to docetaxel and gemcitabine resistant NSCLC cell lines Pasini A., Paganelli G., Tesei A., Zoli W., Giordano E., Calistri D. Laboratory of Cellular and Molecular Engineering S. Cavalcanti, School of Biomedical Engineering University of Bologna, Campus of Cesena, Cesena (FC), Italy; Biosciences Laboratory, IRCCS Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IRST), Meldola (FC), Italy P32 Radiotherapy as an immunological booster in patients with metastatic melanoma or renal cell carcinoma treated with High-dose Interleukin-2 (HD-IL-2) Ridolfi L., Guidoboni M., Nicoletti S.V.L., Romeo A., Ghigi G., Parisi E., Polico R., Petrini M., Fiammenghi L., Granato A.M., Ancarani V., Pancisi E., Soldati V., Valmorri L., Imbalzano S., Riccobon A., Ridolfi R. Immunotherapy, Radiotherapy, Unit of Biostatistics and Clinical Trials, IRCCS Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IRST), Meldola (FC), Italy 15 15

16 PROGRAM P33 The therapeutic activity of gemcitabine on transplanted intracranially Ehrlich tumor in mice Stukov A.N., Gershanovich M.L., Filatova L.V., Semiglazova T.J., Tarasenkova A.A., Latipova D.Kh., Vershinina S.F., Belyaeva O.A., Brezhnev N.V., Moiseyenko F.V., Chubenko V.A. FGBU Research Institute of Oncology named after N.N. Petrov, Saint-Petersburg, Russia Radiotherapy President: R. Polico Chairmen: G. Biti, R. Silvestrini 2.30 p.m. Lecture Radiobiology from the physician s point of view S.C. Formenti 3.00 p.m. Radiobiology from the physicist s point of view M. Benassi, A. Sarnelli 3.25 p.m. Creation of a radiobiology laboratory at IRCCS IRST A. Tesei 3.50 p.m. Discussion Prostate and Kidney President: U. De Giorgi Chairmen: R. Sabbatini, C. Sternberg Prostate cancer: 4.00 p.m. Emerging drugs for the pre-docetaxel space S. Bracarda 4.25 p.m. Which treatment after docetaxel for castrationresistant prostate cancer? C. Sternberg Kidney cancer: 4.50 p.m. Best standard for front-line therapy in metastatic renal cell cancer M. Schmidinger 16 16

17 PROGRAM 5.15 p.m. How to select drugs for TKI resistant metastatic renal cell cancer J. Larkin 5.40 p.m. Discussion Ovarian cancer: Chairmen: B. Kopf, S. Tamberi 6.00 p.m. Lecture Effect of antiangiogenic drugs in ovarian cancer S. Pignata Friday May 11, 2012 Hotel Globus City, Forlì Radiology President: G. Gavelli Chairmen: D. Barone, G. Gavelli 8.30 a.m. Imaging of perfusion of solid-body tumors (ct and mr) M. Bellomi 8.55 a.m. Quantitative vascular measurements with imaging A. Esposito 9.20 a.m. Discussion Lung President: C. Milandri Chairmen: A. Morabito, F. Rea 9.30 a.m. Folate pathway: a special target for chemotherapy? G.V. Scagliotti 9.55 a.m. EGFR inhibitors A. Ardizzoni 17 17

18 10.20 a.m. Anti-angiogenetics R. Chiari a.m. EML4_ALK target E.L. Kwak a.m. Discussion Immunotherapy President: R. Ridolfi Chairmen: P.A. Ascierto, M. Maio a.m. Lecture Target therapies in melanoma J. Weber p.m. Gene-expression profiling in vaccine therapy and immunotherapy for cancer F.M. Marincola p.m. Discussion p.m. Conclusions and Closing Remarks D. Amadori, R. Silvestrini 1.00 p.m. Lunch 18 18

19 GENERAL INFORMATION Meeting venues May 8, 2012 IRCCS Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IRST) Via Maroncelli, Meldola (FC), Italy Ph May , 2012 Hotel Globus City Via Traiano Imperatore, Forlì, Italy Ph hotelglobuscity.com How to reach the meeting venues IRCCS Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IRST), Meldola A shuttle service from Hotel Globus City to Meldola and back will be provided according to the meeting timetable. Please contact the Organizing Secretariat for further information. Hotel Globus City, Forlì By plane: Bologna G. Marconi Airport, 70 km. By car: A14 Bologna-Taranto Motorway, exit Forlì, 500 m. Free parking. By train: Forlì train station, 2 km

20 GENERAL INFORMATION Language The Conference will be in English with no simultaneous translation into other languages. Badge All registered participants, speakers and exhibitors will be given a badge which they must wear to be admitted to the scientific sessions. Attendance certificate A certificate will be given to all participants at the end of the Conference. Italian CME credits Two requests for Italian CME credits have been made for physicians, biologists, technicians, pharmacists, nurses and physicists. The Italian Ministry of Health allows: 5.5 CME credits for May 8-9, CME credits for May 10-11, 2012 At the registration desk attendees will receive two different evaluation forms related to each request. ESMO-MORA points The conference has been awarded the ESMO Label with: 8 ESMO-MORA cat. 1 points. Registration Fees (inclusive of VAT) AIOM members Euro 100 ESMO members Euro 100 ISO members Euro 100 Participants under 35 years Euro 100 Others Euro 200 The registration fees include: participation in the scientific sessions, access to exhibition area, attendance certificate, Conference proceedings dvd, lunches, coffee breaks and welcome cocktail. How to register The completed registration form (also available on line at registration.pdf) and payment must be sent by fax to: Registration can only be accepted and confirmed when the registration form and payment have been received by the Organizing Secretariat Studio E.R. Congressi

21 GENERAL INFORMATION Slides Slides must be in English. Computer videoprojection will be available in a Microsoft Power Point extension. Other requirements should be communicated to the Organizing Secretariat as soon as possible. Slides should be handed to the slide center one hour before the beginning of the session. Hotel Booking and Travel Agency Participants are kindly requested to contact the Hotel Booking and Travel Agency, Bononia Viaggi, in order to arrange their accomodation in Italy. Bononia Viaggi Piazza dei Martiri, Bologna - Italy Ph Fax Changes Parts of the program may be changed if and when necessary without notice

22 NOTES ACKNOWLEDGMENTS 22 22

23 Acknowledgements NOVARTIS ROCHE AMGEN DOMPé ASTELLAS PHARMA ASTRAZENECA BRISTOL MYERS SQUIBB ELI LILLY ITALIA JANSSEN PFIZER ITALIA TEVA ITALIA BAYER SCHERING PHARMA CELGENE SANOFI-AVENTIS EISAI GLAXOSMITHKLINE IPSEN ITALFARMACO MERCK SERONO SANDOZ BIOPHARMACEUTICALS

24 Scientific Secretariat IRCCS Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IRST) Via Maroncelli, Meldola (FC), Italy Ph Organizing Secretariat Studio E.R. Congressi - Triumph Group Via Marconi, Bologna, Italy Ph Fax Guido Cagnacci, Ratto di Europa (1644/45 ca.) - Collezione Molinari Pradelli, Bologna

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