BIOGRAPHICAL SKETCH (February 16, 2013)

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1 BIOGRAPHICAL SKETCH (February 16, 2013) NAME Arús Caraltó, Carles Male. Born December 21 st, 1954, at Barcelona, Spain. Married, one son and one daughter. POSITION TITLE Full Professor of Biochemistry and Molecular Biology EDUCATION/TRAINING INSTITUTION AND LOCATION DEGREE (if applicable) YEAR(s) FIELD OF STUDY Universitat Autònoma de Barcelona (UAB), Cerdanyola del Vallès, Spain BSc Biology UAB, Cerdanyola del Vallès, Spain MsC Biochemistry UAB, Cerdanyola del Vallès, Spain PhD Chemistry University of Illinois, School of Medicine at Chicago, Chicago, IL, USA A. Positions and honors postdoctoral Biomedical NMR Teaching assistant and predoctoral fellow at UAB, Spain Best PhD thesis award at UAB (Chemistry), (Advisor: Claudi M. Cuchillo) Research Associate. University of Illinois at Chicago, Chicago Il, USA (Advisors: Michael Bárány at Illinois and John L. Markley at Purdue University, Indiana) Postdoctoral research fellowship from the Muscular Distrophy Association (USA) Tenured Assistant Professor of Biochemistry and Molecular Biology at UAB, Spain present Full Professor of Biochemistry and Molecular Biology at UAB, Spain. B. Selected peer-reviewed publication information Publications selected from 115 entries according to the ISI web of knowledge, h index: 29. Total number of citations 2436, as of February 16, Further details are available from the ResarcherID link at: At left, cummulative citation distribution by year from the ResearcherID web page. See also annex 1 at the end of the CV for full publication list. 1

2 Ten selected peer-reviewed publications (in decreasing order of citations, see also annex 1 at the end of the CV for full publications list) 1 Barba I, Cabanas ME, Arus C. The relationship between nuclear magnetic resonance-visible lipids, lipid droplets, and cell proliferation in cultured C6 cells. Cancer Res. 1999;59: PMID: Times Cited: 128. First demonstration of the correlation between an NMR non-invasive biomarker, the mobile lipid resonances, and proliferation rate in cultured glioma cells. 2 Tate AR, Majos C, Moreno A, Howe FA, Griffiths JR, Arus C. Automated classification of short echo time in in vivo 1H brain tumor spectra: a multicenter study. Magn Reson Med. 2003; 49: PMID: Times cited: 111. Demonstration of the ability to produce classifiers, mathematical formula that may automatically discriminate the in vivo NMR pattern of three major human brain tumour types, with potential for decision support system use. 3 Remy C, Fouilhe N, Barba I, Sam-Lai E, Lahrech H, Cucurella MG, Izquierdo M, Moreno A, Ziegler A, Massarelli R, Decorps M, Arus C. Evidence that mobile lipids detected in rat brain glioma by 1H nuclear magnetic resonance correspond to lipid droplets. Cancer Res. 1997; 57: PMID: Times cited: 104. First full demonstration that the so called NMR visible MR lipids (ML) did arise from the triacylglycerol content of extracellular (necrotic cores) and cytosolic (viable tumour tissue) lipid droplets. 4 Tate AR, Underwood J, Acosta DM, Julia-Sape M, Majos C, Moreno-Torres A, Howe FA, van der Graaf M, Lefournier V, Murphy MM, Loosemore A, Ladroue C, Wesseling P, Luc Bosson J, Cabanas ME, Simonetti AW, Gajewicz W, Calvar J, Capdevila A, Wilkins PR, Bell BA, Remy C, Heerschap A, Watson D, Griffiths JR, Arus C. Development of a decision support system for diagnosis and grading of brain tumours using in vivo magnetic resonance single voxel spectra. NMR Biomed. 2006;19: PMID: Times cited: 94. Description of the major result of the EU funded INTERPRET project coordinated by C. Arús, the decision support system (DSS) for human brain tumour diagnosis using in vivo MRS, and an initial study of its added value over MRI use alone. 5 Tate AR, Griffiths JR, Martinez-Perez I, Moreno A, Barba I, Cabanas ME, Watson D, Alonso J, Bartumeus F, Isamat F, Ferrer I, Vila F, Ferrer E, Capdevila A, Arus C. Towards a method for automated classification of 1H MRS spectra from brain tumours. NMR Biomed. 1998;11: PMID: Times cited: 93. Outline of the required path for a successful decision support system development for human brain in vivo MRS pattern-based non-invasive diagnostic. 6 Remy C, Arus C, Ziegler A, Lai ES, Moreno A, Le Fur Y, Decorps M. In vivo, ex vivo, and in vitro one- and two-dimensional nuclear magnetic resonance spectroscopy of an intracerebral glioma in rat brain: assignment of resonances. J Neurochem. 1994; 62: PMID: Times cited: 90. One of the first attempts to fully account for the in vivo pattern of a brain tumour in a preclinical rat model using correlation to ex vivo and in vitro data. 7 Barany M, Chang YC, Arus C, Rustan T, Frey WH 2nd. Increased glycerol-3-phosphorylcholine in post-mortem Alzheimer's brain. Lancet. 1985;1(8427):517. PMID: Times cited: 88. Ex vivo demonstration of in vitro changes in the NMR pattern on phosphorylated metabolites found in Alzheimer vs control post-mortem human brain tissue, which was later found in preclinical studies and in humans, in vivo. 8 Quintero M, Cabanas ME, Arus C. A possible cellular explanation for the NMR-visible mobile lipid (ML) changes in cultured C6 glioma cells with growth. Biochim Biophys Acta. 2007;1771:

3 PMID: Times cited: 27. First data-supported explanation of the recycling of plasma membrane phospholipids between plasma membrane and endoplasmic reticulum through lipid droplet transport in the form of its triacylgycerol content, and its relationship to NMR-visible mobile lipids in C6 glioma cells. 9 Simões RV, Delgado-Goñi T, Lope-Piedrafita S, Arús C. (1)H-MRSI pattern perturbation in a mouse glioma: the effects of acute hyperglycemia and moderate hypothermia. NMR Biomed Jan;23(1):23-33.PMID: Times cited: 7. Demonstration that the in vivo MRS pattern can be reversibly perturbed by transient hyperglycemia and that this can be used to demonstrate tumour heterogeneity in GL261 grade IV glioma-bearing mice using molecular imaging-based MRSI. 10 Ortega-Martorell S, Olier I, Julià-Sapé M, Arús C. SpectraClassifier 1.0: a user friendly, automated MRS-based classifier-development system. BMC Bioinformatics Feb 24;11:106.PMID: Times cited: 5. New platform-independent software tool for the semiautomated development and performance evaluation of classifiers from MR spectral vectors and its rendering in a format compatible with a DSS previously developed by the GABRMN group. C. Research support (see also annex 2 at the end of the CV for full research support list) Ongoing research support 1. Transforming Magnetic Resonance Spectroscopy into a Clinical Tool (TRANSACT), EU FP7-PEOPLE-2012-ITN Project number , 1/3/2013-1/3/2017, Coordinator (Sabine van Huffel (BE), PI for the UAB partner: Carles Arús. 2. Improvement of Magnetic Resonance based Molecular Imaging strategies for brain cancer diagnosis and therapy response monitoring (MARESCAN). Spanish Ministry of Science and Innovation, SAF /1/12-12/31/14. The goal of MARESCAN is to produce MRSIbased molecular imaging strategies of response to therapy in preclinical brain tumours and carry out a proof-of-concept in humans. Role: PI. 3. Dynamic Nuclear Polarizer Hypersense. Scientific and Technologic Infrastructure from the Spanish Ministry of Science and Innovation, UNAB08-4E-004, System from Oxford Systems to increase polarization of substances in the solid phase and bring it in seconds to physiologic temperature for ultrafast molecular imaging experiments in an in vivo MR scanner. Role PI. 4. Director of a CIBER-BBN Research Group (GABRMN-UAB; CIBER-BBN group CB ) of the Networking Research Center on Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN, Instituto de Salud carlos III (ISCiii). 01/01/06-12/31/13 (renewable for 4 year periods). The goal of this network is to foster collaborative research among spanish groups in the area of Bioengineering, Biomaterials and Nanomedicine through stable funding. Role: PI of the GABRMN-UAB group of the network grant. 5. Intramural CIBER-BBN Project. Improving diagnosis, prognosis and therapy response in glioma and stroke. Preclinical and translational studies, part 2. (PROGLIO2). Área de Bioingenieria, 11 CIBER-BBN groups, Role: Project coordinator. 3

4 Completed research support Phenotype and molecular imaging of brain cancer progression by MRS/MRI in murine models. Translational application to humans (PHENOIMA). Spanish Ministry of Science and Innovation, SAF , 1/1/09-12/31/11. The goal of the project is to demonstrate molecular phenotyping by MRS in animal models of brain tumors and propose translational protocols for human subjects. Role: PI. 2. Intramural CIBER-BBN Project. Optimización del diagnóstico, pronóstico y terapia de glioma humano. Estudios preclínicos y traslacionales (PROGLIO). Área de Bioingenieria, Role: Project coordinator. 3. Intramural CIBER-BBN project IMAFEN Desarrollo de estrategias de imagen molecular y de fenotipo, in vivo de modelos murinos de tumores gliales y de enfermedad de Alzheimer (IMAFEN), 12 CIBER-BBN groups, Role: Project coordinator. 4. etumour (European Union, FP LIFESCIHEALTH ), 02/01/04-07/31/09. The goal of this project is to create a web accessible MR decision support system for brain tumor diagnosis and prognosis, incorporating in-vivo and ex-vivo genomic and metabolomic data. Role: Co-investigator and PI of UAB partner. 5. Health Agents (European Union, IST ). 01/01/06-12/31/08. The goal of this project has been to improve the classification of brain tumours by using a distributed network of local data marts and to send and retrieve brain tumour MR data through a multi-agent based network. Role: Co-investigator and PI of UAB partner. 6. Improvement of diagnostic and prognostic evaluation of human brain tumours in vivo. Metabolomics of tumour progression in cellular and animal models. Phase 2 (MEDIVO2), (Spanish Ministry of Education, SAF ).12/31/05-12/31/08.The goal of the project has been to improve the diagnosis and prognostic evaluation of human brain tumors in-vivo and in animal models of the disease. Role: PI. 7. NMR spectrometer (7T) for small animal work. Scientific and Technologic Infrastructure from the Spanish Ministry of Science and Education, UNAB A BioSpec USR 70/30 system has been deployed at UAB for studies with animal models (mice, rat) of human disease Role: PI. D. Other merits - Director of a multidisciplinary research group Grup d aplicacions biomèdiques de la RMN, GABRMN since 2002 (url: which is also an established CIBER-BBN group since 2006 (group CB , and recognized as a consolidated research group by the Generalitat de Catalunya since 2002 (present reference number: 2009/SGR-00926). - Member of the Institut de Biologia i de Biomedicina (http://ibb.uab.es/ibb/) of the UAB since Five six-year research performance periods granted by the Spanish State research evaluation system. - Six five-year University teaching performance periods granted by the Spanish State public University evaluation system. 4

5 - Adviser for 12 PhD Thesis and 19 Master degree reports in the period Maintenance and access to DSS and MRS processing software available from the GABRMN web page Maintenance at the GABRMN of databases containing MR data of scientific and clinical interest https://dbtest.etumour.net:9091/etumour/, - PI of a CIBER-BBN Infrastructure Bio-Imaging Platform based at UAB: Plataforma de Equipamiento: Bio-imagen. Unidad de RMN. Aplicaciones Biomédicas I ; - Coordinator of the PhD Programme in Biochemistry and Molecular Biology at UAB ( ) - Head of the Sciences Unit of the Department of Biochemistry and Molecular Biology at UAB ( and ). - Coordinator of the Biochemistry Bachelor degree at UAB ( ). - Member of Societies: Sociedad Española de Bioquímica y Biología Molecular (SEBBM), associated member since 1978 and full member since 1997; International Society of Magnetic Resonance in Medicine (ISMRM, formerly SMRM) since 1984; Sociedad de Biofísica de España (SEB) since 1986; European Society of Magnetic Resonance in Medicine and Biology (ESMRMB) since Member of the Executive Board of the European Society of Magnetic Resonance in Medicine and Biology (ESMRMB) and Chairperson of the Scientific Program Committee ( ) of the 25 th Annual Congress of the ESMRMB at Valencia (ES), Grant reviewer for: Agencia Nacional de Evaluación y Prospectiva (ANEP), Spain; Cancer Research Campaign, UK; Samantha Dickson Brain Tumour Trust, UK; Swiss National Science Foundation, SW; Medical Research Council, UK; The Netherlands Organisation for Scientific Research (NWO), NE. - Tenure track evaluation of candidates for: Johns Hopkins School of Medicine, USA; Newcastle University, UK. - Editorial Board membership and reviewer activities. Editorial Board member and reviewer for Magnetic Resonance Materials in Physics Biology and Medicine, MAGMA; frequent reviewer for NMR in Biomedicine, Magnetic Resonance in Medicine, Magnetic Resonance Materials in Physics Biology and Medicine, MAGMA; ocasional reviewer for Cancer Research, British Journal of Cancer, Biochimica et Biophysica Acta. 5

6 Annex 1 Full publication list for Carles Arús 1. Delgado-Goñi T, Martín-Sitjar J, Simões RV, Acosta M, Lope-Piedrafita S, Arús C. Dimethyl sulfoxide (DMSO) as a potential contrast agent for brain tumors. NMR Biomed Feb;26(2): Ortega-Martorell, S, Lisboa, PJG, Vellido A, Simões RV,Pumarola M, Julià-Sapé M, Arús C. Convex Non-Negative Matrix Factorization for Brain Tumor Delimitation from MRSI Data. PLOS ONE, 2012;7(10):e Julià-Sapé M, Lurgi M, Mier M, Estanyol F, Rafael X, Candiota AP, Barceló A, García A, Martínez- Bisbal MC, Ferrer-Luna R, Moreno-Torres A, Celda B, Arús C. Strategies for annotation and curation of translational databases: the etumour project. Database-Oxford, Database (Oxford), 2012:bas035. doi: /database/bas Martín-Sitjar J, Delgado-Goñi T, Cabañas ME, Tzen J, Arús C. Influence of the spinning rate in the HR-MAS pattern of mobile lipids in C6 glioma cells and in artificial oil bodies. Magnetic Resonance Materials in Physics Biology and Medicine, MAGMA. 2012, 25: Simões RV, Candiota AP, Julià-Sapé M, Arús C. In vivo magnetic resonance spectroscopic imaging and ex vivo quantitative neuropathology by high resolution magic angle spinning proton magnetic resonance spectroscopy. Neuromethods. Chapter 30. DOI /7657_2011_31, Springer Science+Business Media, LLC Castells X, Acebes JJ, Majós C, Boluda S, Julià-Sapé M, Candiota AP, Ariño J, Barceló A, Arús C. Development of robust discriminant equations for assessing subtypes of glioblastoma biopsies. Br J Cancer May 22;106(11): Cavalli S, Carbajo D, Acosta M, Lope-Piedrafita S, Candiota AP, Arús C, Royo M, Albericio F. Efficient γ-amino-proline-derived cell penetrating peptide-superparamagnetic iron oxide nanoparticle conjugates via aniline-catalyzed oxime chemistry as bimodal imaging nanoagents. Chem Commun (Camb) May 28;48(43): Ortega-Martorell S, Lisboa PJ, Vellido A, Julià-Sapé M, Arús C. Non-negative matrix factorisation methods for the spectral decomposition of MRS data from human brain tumours. BMC Bioinformatics Mar 8;13: Davila M, Candiota AP, Pumarola M, Arus C. Minimization of spectral pattern changes during HRMAS experiments at 37 degrees celsius by prior focused microwave irradiation. MAGMA, 2012 Oct;25(5): Simões RV, Ortega-Martorell S, Delgado-Goñi T, Le Fur Y, Pumarola M, Candiota AP, Martín J, Stoyanova R, Cozzone PJ, Julià-Sapé M, Arús C. Improving the classification of brain tumors in mice with perturbation enhanced (PE)-MRSI. Integr Biol (Camb) Feb;4(2): Vellido A, Romero E, Julià-Sapé M, Majós C, Moreno-Torres Á, Pujol J, Arús C. Robust discrimination of glioblastomas from metastatic brain tumors on the basis of single-voxel (1)H MRS. NMR Biomed Jun;25(6):

7 12. Julià-Sapé M, Coronel I, Majós C, Candiota AP, Serrallonga M, Cos M, Aguilera C, Acebes JJ, Griffiths JR, Arús C. Prospective diagnostic performance evaluation of single-voxel 1H MRS for typing and grading of brain tumours. NMR Biomed Apr;25(4): Candiota AP, Majós C, Julià-Sapé M, Cabañas M, Acebes JJ, Moreno-Torres A, Griffiths JR, Arús C. Non-invasive grading of astrocytic tumours from the relative contents of myo-inositol and glycine measured by in vivo MRS. JBR-BTR Nov-Dec;94(6): Tortajada S, Fuster-Garcia E, Vicente J, Wesseling P, Howe FA, Julià-Sapé M, Candiota AP, Monleón D, Moreno-Torres A, Pujol J, Griffiths JR, Wright A, Peet AC, Martínez-Bisbal MC, Celda B, Arús C, Robles M, García-Gómez JM. Incremental Gaussian Discriminant Analysis based on Graybill and Deal weighted combination of estimators for brain tumour diagnosis. J Biomed Inform. 44: , Fuster-Garcia E, Navarro C, Javier V,Tortajada S, García-Gómez J, Sáez C, Calvar J, Griffiths J, Julià -Sapé M, Howe F, Pujol J, Peet A, Heerschap A, Moreno-Torres A, Martínez-Bisbal MC, Martínez-Granados B, Wesseling P, Semmler W, Capellades J, Majós C, Capdevila A, Monleon D, Martí-Bonmatí L, Arús C, Celda B, Robles M. Compatibility between 3T 1H SV-MRS data and automatic brain tumour diagnosis support systems based on databases of 1.5T 1H SV- MRS spectra. Magnetic Resonance Materials in Physics Biology and Medicine, MAGMA, 24:35-42, Majós C, Bruna J., Julià-Sapé M, Cos, M., Camins A, Gil, M., Aguilera C, Arús C. Proton magnetic resonance spectroscopy provides relevant prognostic information in high-grade astrocytomas. American Journal of Neuroradiogy, AJNR 32: 74-80, Pérez-Ruíz A, Julià-Sapé M, Mercadal G, Olier I, Majós C, Arús C. The INTERPRET Decision- Support Sytem version 3.0 for the evaluation of Magnetic Resonance Spectroscopy data from human brain tumours and other abnormal brain masses. BMC Bioinformatics 11:581, 2010, doi: / Julia-Sape M, Majos C, Arus C. Diagnosis and staging of brain tumours:magnetic resonance single voxel spectra. In Methods of cancer diagnosis, therapy, and prognosis Vol 8, Chapter 19, pp , Springer, ISBN Valverde, D., Candiota, A.P., Molins, M.A., Feliz M., Godino O., Martino J., Dávila, M., Acebes J.J., Arús C. Short term temperature effect on the HRMAS spectra of human brain tumor biopsies and their pattern recognition analysis. Magnetic Resonance Materials in Physics Biology and Medicine, MAGMA 23: , Quintero, M.R., Cabañas, M.E. Arús, C. 13C-labelling studies indicate compartmentalized synthesis of triacylglycerols in C6 rat glioma cells. Biochimica Biophysica Acta - Molecular and Cell Biology of Lipids 1801: , González-Navarro, F.F., Belanche-Muñoz, Ll.A., Romero, E.,Vellido, A., Julià-Sapé, M., Arús, C. Feature and model selection with discriminatory visualization for diagnostic classification of brain tumours. Neurocomputing 73: , Castells, X., Acebes, J.J., Boluda, S., Moreno, A., Pujol, J., Julià-Sapé, M., Candiota, A.P., Ariño, J., Barceló, A., Arús, C. Development of a Predictor for Human Brain Tumours Based on Gene Expression Values Obtained From Two Types of Microarray Technologies. OMICS: a Journal of Integrative Biology 14: , Ortega-Martorell S, Olier, Iván, Julià-Sapé, M, Arús C. SpectraClassifier 1.0: a user friendly, automated MRS-based classifier-development system. BMC Bioinformatics 11:106,

8 24. Simões RV, Delgado-Goñi, Lope-Piedrafita S, Arús C. 1 H-MRSI pattern perturbation in mouse glioma: effects of acute hyperglycemia and moderate hypothermia. NMR in Biomedicine 23:23-33, Castells, X., García-Gómez, J.M., Navarro, A., Acebes J.J., Godino O., Boluda S., Barceló A., Robles M., Ariño A., Arús C. Automated brain tumour biopsy prediction using singlelabelling cdna microarrays-based gene expression profiling. Diagnostic Molecular Pathology 18: , Vellido, A.; Romero, E.; González-Navarro, F.F.; Belanche-Muñoz, L.A.; Julià-Sapé, M.; Arús, C. Outlier exploration and diagnostic classification of a multi-centre H-MRS brain tumour database. Neurocomputing 72: , Majós C, Aguilera C, Cos M, Camins A, Candiota AP, Delgado-Goñi T, Samitier A, Castañer S, Sánchez JJ, Mato D, Acebes JJ, Arús C. In vivo proton magnetic resonance spectroscopy of intraventricular tumours of the brain. European Radiology 19: , Gonzalez-Velez H, Mier M, Julià-Sapé M, Arvanitis TN, Garcia-Gomez JM, Robles M, Lewis, P.H., Dasmahapatra, S., Dupplae, D., Peet, A., Arús, C., Celda, B., Van Huffel, S., Lluch-Ariet, M. HealthAgents: Distributed Multi-Agent Brain Tumour Diagnosis and Prognosis. Applied Intelligence 30: , Majós C., Aguilera C., Alonso J., Julià-Sapé M., Castañer S., Sánchez J.J., Samitier A., Cos M., Camins A., León A., Acebes J.J., Rovira A., Arús C. Proton MR spectroscopy improves discrimination between tumor and pseudotumoral lesion in solid brain masses. American Journal of Neuroradiology 30: , Vellido A, Julia-Sape M, Romero E, Arus C. Exploratory characterization of ouliers in a multicentre 1H-MRS brain tumour dataset. Lecture notes in computer science 5178: , Springer Berlin/Heidelberg, ISBN: / Nebot A, Castro F, Vellido A, Julia-Sape M, Arus C. Rule-based assistance to brain tumour diagnosis using LR-FIR. Lecture notes in computer science 5178: , Springer Berlin/Heidelberg, ISBN: / García-Gómez JM, Luts J, Julià-Sapé M, Krooshof P, Tortajada S, Robledo JV, Melssen W, Fuster-García E, Olier I, Postma G, Monleón D, Moreno-Torres A, Pujol J, Candiota AP, Martínez-Bisbal MC, Suykens J, Buydens L, Celda B, Van Huffel S, Arús C, Robles M. Multiproject-multicenter evaluation of automatic brain tumor classification by magnetic resonance spectroscopy. Magnetic Resonance Materials in Physics Biology and Medicine, MAGMA 22:5-18, García-Gómez, J.M, Tortajada, S., Vidal, C., Julià-Sapé, M., Luts, J., Moreno-Torres, A., van Huffel, S., Arús, C., Robles., M. The effect of combining two echo times in automatic brain tumor classification by MRS. NMR in Biomedicine 21: , Julià- Sapé, M, Arús, C. MRS in Clinical Practice. Application to Brain Tumour MRS, in IEEE International Workshop on Imaging Systems and Techniques pp: , IEEE, 345 E 47th st, New York 10017, USA, ISBN: Simões RV, Martinez-Aranda A, Martín B, Cerdán S, Sierra A, Arús C. Preliminary characterization of an experimental breast cancer cells brain metastasis mouse model by MRI/MRS. Magnetic Resonance Materials in Physics Biology and Medicine, MAGMA 21: ,

9 36. Wright A., Arús C., Wijnen J., Moreno-Torres A., Griffiths J., Celda, B., Howe, F. An automated Quality Control Protocol for MR Spectra of Brain Tumours. Magnetic Resonance in Medicine 59: , Simões R.V., García-Martín M.L., Cerdán S., Arús C. Perturbation of mouse glioma MRS pattern by induced acute hyperglycemia. NMR in Biomedicine 21: , Van der Graff, M., Julià-Sapé, M., Howe, F., Ziegler, A., Majós, C., Moreno-Torres, A., Rijpkema, M., Acosta, D., Opstad, K., van der Meulen, Y., Arús, C., Heerschap, A. MRS quality assessment in a multicentre study on MRS-based classification of brain tumours. NMR in Biomedicine 21: , Simoes RV, Garcia-Martin ML, Cerdan S, Arus C. Perturbation of mouse glioma MRS pattern by induced acute hyperglycemia. NMR in Biomedicine 21: , García-Gómez, J.M, Tortajada, S., Vicente, J., Sáez, C., Castells, X., Luts, J., Julià-Sapé, M., Juan-Císcar, A., van Fuel, S., Barceló, A., Ariño, J., Arús, C., Robles., M. Genomics and Metabolomics Research for Brain Tumour Diagnosis Based on Machine Learning. Lecture Notes in Computer Science Conference (9th International Work-Conference on Artificial Neural Networks) 4507: , Poullet JB, Martinez-Bisbal MC, Valverde D, Monleon D, Celda B, Arús C, Van Huffel S. Quantification and classification of high-resolution magic angle spinning data for brain tumor diagnosis. Conf Proc IEEE Eng Med Biol Soc. 2007: , Lu C, Devos A, Suykens JA, Arus C, Van Huffel S. Bagging linear sparse Bayesian learning models for variable selection in cancer diagnosis. IEEE Trans Inf Technol Biomed. 11: , Oriol A, Valverde D, Capellades J, Cabanas ME, Ribera JM, Arus C. In vivo quantification of response to treatment in patients with multiple myeloma by 1H magnetic resonance spectroscopy of bone marrow. Magnetic Resonance Materials in Physics Biology and Medicine, MAGMA. 20:93-101, Rodriguez E, Simoes RV, Roig A, Molins E, Nedelko N, Slawska-Waniewska A, Aime S, Arus C, Cabanas ME, Sanfeliu C, Cerdan S, Garcia-Martin ML. An iron-based T1 contrast agent made of iron-phosphate complexes: in vitro and in vivo studies. Magnetic Resonance Materials in Physics Biology and Medicine, MAGMA 20:27-37, Quintero M, Cabanas ME, Arus C. A possible cellular explanation for the NMR-visible mobile lipid (ML) changes in cultured C6 glioma cells with growth. Biochimica Biophysica Acta - Molecular and Cell Biology of Lipids 1771:31-44, Julia-Sape M, Acosta D, Majos C, Moreno-Torres A, Wesseling P, Acebes JJ, Griffiths JR, Arus C. Comparison between neuroimaging classifications and histopathological diagnoses using an international multicenter brain tumor magnetic resonance imaging database. J Neurosurg. 105:6-14, Tate AR, Underwood J, Acosta DM, Julia-Sape M, Majos C, Moreno-Torres A, Howe FA, van der Graaf M, Lefournier V, Murphy MM, Loosemore A, Ladroue C, Wesseling P, Luc Bosson J, Cabanas ME, Simonetti AW, Gajewicz W, Calvar J, Capdevila A, Wilkins PR, Bell BA, Remy C, Heerschap A, Watson D, Griffiths JR, Arus C. Development of a decision support system for diagnosis and grading of brain tumours using in vivo magnetic resonance single voxel spectra. NMR Biomed. 19: ,

10 48. Diekmann, C., Simoes, R., Rolf, P., Cerdán, S., Arús, C. Proton Chemical shift imaging of mouse brain tumors at 7T. Bruker SpinReport 157/2006, ISSN: , Valverde D, Quintero MR, Candiota AP, Badiella L, Cabanas ME, Arus C. Analysis of the changes in the 1H NMR spectral pattern of perchloric acid extracts of C6 cells with growth. NMR Biomed. 19: , Julia-Sape M, Acosta D, Mier M, Arus C, Watson D; INTERPRET consortium. A multi-centre, web-accessible and quality control-checked database of in vivo MR spectra of brain tumour patients. Magnetic Resonance Materials in Physics Biology and Medicine, MAGMA, 19:22-33, Rodriguez E, Roig A, Molins E, Arus C, Quintero MR, Cabanas ME, Cerdan S, Lopez-Larrubia P, Sanfeliu C. In vitro characterization of an Fe(8) cluster as potential MRI contrast agent. NMR Biomed. 18: , Majos C, Julia-Sape M, Alonso J, Serrallonga M, Aguilera C, Acebes JJ, Arus C, Gili J. Brain tumor classification by proton MR spectroscopy: comparison of diagnostic accuracy at short and long TE. Am J Neuroradiol, AJNR, 25: , Moreno-Torres A, Martinez-Perez I, Baquero M, Campistol J, Capdevila A, Arus C, Pujol J. Taurine detection by proton magnetic resonance spectroscopy in medulloblastoma: contribution to noninvasive differential diagnosis with cerebellar astrocytoma. Neurosurgery 55: , Candiota AP, Majos C, Bassols A, Cabanas ME, Acebes JJ, Quintero MR, Arus C. Assignment of the 2.03 ppm resonance in in vivo 1H MRS of human brain tumour cystic fluid: contribution of macromolecules. Magnetic Resonance Materials in Physics Biology and Medicine, MAGMA, 17:36-46, Devos A, Lukas L, Suykens JA, Vanhamme L, Tate AR, Howe FA, Majos C, Moreno-Torres A, van der Graaf M, Arus C, Van Huffel S. Classification of brain tumours using short echo time 1H MR spectra. J Magn Reson. 170: , Santos MG, Gonzalez de Suso JM, Moreno A, Cabanas M, Arus C. [Muscular energetic metabolism study in athletes using 31P-MRS]. Rev Assoc Med Bras. 50: , Lukas L, Devos A, Suykens JA, Vanhamme L, Howe FA, Majos C, Moreno-Torres A, Van der Graaf M, Tate AR, Arus C, Van Huffel S. Brain tumor classification based on long echo proton MRS signals. Artif. Intell. Med. 31:73-89, Majos C, Alonso J, Aguilera C, Serrallonga M, Coll S, Acebes JJ, Arus C, Gili J. Utility of proton MR spectroscopy in the diagnosis of radiologically atypical intracranial meningiomas. Neuroradiology 45: , Majos C, Alonso J, Aguilera C, Serrallonga M, Perez-Martin J, Acebes JJ, Arus C, Gili J. Proton magnetic resonance spectroscopy ((1)H MRS) of human brain tumours: assessment of differences between tumour types and its applicability in brain tumour categorization. Eur Radiol 13: , Tate AR, Majos C, Moreno A, Howe FA, Griffiths JR, Arus C. Automated classification of short echo time in in vivo 1H brain tumor spectra: a multicenter study. Magn Reson Med. 49:29-36,

11 61. Lisboa, P.J.G., El-Deredy, W., Lee, Y.Y.B., Huang, Y., Corona Hernandez, Arús, C. and Harris, P. Characterization of brain tissue from MR spectra for tumour discrimination in Signal processing for magnetic resonance imaging and spectroscopy, Chapter 19, pp , Marcel Dekker, Inc, New York, USA Minguillón, J., Tate, A.R., Arús, C., Griffiths, J. Classifier combination for in vivo Magnetic Resonance Spectra of brain tumours. Lecture Notes in Computer Science 2364: , Majos C, Alonso J, Aguilera C, Serrallonga M, Acebes JJ, Arus C, Gili J. Adult primitive neuroectodermal tumor: proton MR spectroscopic findings with possible application for differential diagnosis. Radiology 225: , Perez Y, Lahrech H, Cabanas ME, Barnadas R, Sabes M, Remy C, Arus C. Measurement by nuclear magnetic resonance diffusion of the dimensions of the mobile lipid compartment in C6 cells. Cancer Res. 62: , Barba, I., Cabañas, M., Arús, C. [Tumores cerebrales. Tasa de proliferación]. Investigación y Ciencia N 304 pp , Arús, C. [Espectroscopia in vivo y metabolismo]. Curso avanzado de Resonancia Magnética Nuclear, pp , 2001, Ed. J. Santoro. Comité de Espectroscopia, SEDO, Madrid. 67. Underwood J, Tate AR, Luckin R, Majos C, Capdevila A, Howe F, Griffiths J, Arus C. A prototype decision support system for MR spectroscopy-assisted diagnosis of brain tumours. 10th World Congress on Medical Informatics (MEDINFO 2001) 84: , Barba I, Mann P, Cabanas ME, Arus C, Gasparovic C. Mobile lipid production after confluence and ph stress in perfused C6 cells. NMR Biomed. 14:33-40, Barba I, Moreno A, Martinez-Perez I, Tate AR, Cabanas ME, Baquero M, Capdevila A, Arus C. Magnetic resonance spectroscopy of brain hemangiopericytomas: high myoinositol concentrations and discrimination from meningiomas. J Neurosurg. 94:55-60, Lee, Y.Y.B. Huang, Y., El-Deredy, W., Lisboa, P.J.G. Arús, C., Harris, P. Robust methodology for the discrimination of brain tumours from in vivo magnetic resonance spectra. Institute of Electrical Engineers Proceedings Science of Measuring Tecnologies 147: , Barba I, Cabanas ME, Arus C. The relationship between nuclear magnetic resonance-visible lipids, lipid droplets, and cell proliferation in cultured C6 cells. Cancer Res. 59: , Gray HF, Maxwell RJ, Martinez-Perez I, Arus C, Cerdan S. Genetic programming for classification and feature selection: analysis of 1H nuclear magnetic resonance spectra from human brain tumour biopsies. NMR Biomed. 11: , Tate AR, Griffiths JR, Martinez-Perez I, Moreno A, Barba I, Cabanas ME, Watson D, Alonso J, Bartumeus F, Isamat F, Ferrer I, Vila F, Ferrer E, Capdevila A, Arus C. Towards a method for automated classification of 1H MRS spectra from brain tumours. NMR Biomed. 11: , Moreno A, Lopez LA, Fabra A, Arus C. 1H MRS markers of tumour growth in intrasplenic tumours and liver metastasis induced by injection of HT-29 cells in nude mice spleen. NMR Biomed. 11:93-106,

12 75. Gasparovic C, Barba I, Born J, Barton S, Arus C, Mann P. A study of imidazole-based nuclear magnetic resonance probes of cellular ph. Anal Biochem. 261:64-72, Maxwell RJ, Martinez-Perez I, Cerdan S, Cabanas ME, Arus C, Moreno A, Capdevila A, Ferrer E, Bartomeus F, Aparicio A, Conesa G, Roda JM, Carceller F, Pascual JM, Howells SL, Mazucco R, Griffiths JR. Pattern recognition analysis of 1H NMR spectra from perchloric acid extracts of human brain tumor biopsies. Magn Reson Med. 39: , Barba I, Gasparovic C, Cabanas ME, Alonso J, Murillo I, San Segundo B, Arus C. Measurement of intracellular ph of maize seeds (Zea mays) during germination by 31P nuclear magnetic resonance spectroscopy. Cell Mol Biol (Noisy-le-grand) 43: , Martinez-Perez I, Moreno A, Alonso J, Aguas J, Conesa G, Capdevila A, Arus C. Diagnosis of brain abscess by magnetic resonance spectroscopy. Report of two cases. J Neurosurg. 86: , Remy C, Fouilhe N, Barba I, Sam-Lai E, Lahrech H, Cucurella MG, Izquierdo M, Moreno A, Ziegler A, Massarelli R, Decorps M, Arus C. Evidence that mobile lipids detected in rat brain glioma by 1H nuclear magnetic resonance correspond to lipid droplets. Cancer Res. 57: , González de Suso, J.M., Alonso, J., Moreno, A., Aldomà, J., Arús, C., Capdevila, A., Gili, J. [Imagen y Espectroscopía por Resonancia Magnética en el Deporte] in "Olimpismo y Medicina Deportiva". Eds. J.F. Marcos R. Santonja Gómez pp , 1996, Impresión, S.A., Madrid. 81. Moreno A, Arus C. Quantitative and qualitative characterization of 1H NMR spectra of colon tumors, normal mucosa and their perchloric acid extracts: decreased levels of myoinositol in tumours can be detected in intact biopsies. NMR Biomed. 9:33-45, González de Suso, J.M., Alonso, J., Bernús, G., Prat, J.A., Arús, C. [Estudio por 31P-MRS del ph muscular durante la recuperación de esfuerzos de intensidad elevada y corta duración]. CAR News (Colección de fascículos sobre entrenamiento de alto rendimiento y proyectos de investigación asociados). Nº: 10 pp. 4-7, CAR/Sandoz Sport Research, Sant Cugat del Vallés. 83. González de Suso, J.M., Alonso, J., Bernús, G., Prat, J.A., Alvarez, J., Arús, C. [Cambios en el ph muscular y en la concentración de lactato sanguíneo después de ejercicios intermitentes de intensidad elevada] CAR News (Colección de fascículos sobre entrenamiento de alto rendimiento y proyectos de investigación asociados), Nº: 10 pp 8-11, CAR/Sandoz Sport Research, Sant Cugat del Vallés. 84. Gasparovic C, Cabanas M, Arus C. A simple approach to the design of a shielded gradient probe for high-resolution in vivo spectroscopy. J Magn Reson B. 109: , González de Suso, J.M., Bernús, G., Alonso, J., Pujol, P., Prat, J.A., Arús, C. [Cambios bioquímicos producidos en el músculo esquelético después de una carrera de maratón]. CAR News (Colección de fascículos sobre entrenamiento de alto rendimiento y proyectos de investigación asociados), Nº: 2 pp. 4-9, 1994, CAR/Sandoz Sport Research, Sant Cugat del Vallés. 86. Bernús, G., González de Suso, J.M., Alonso, J., Martin, P.A., Prat, J.A., Arús, C. [Diferencias cuantitativas en el músculo quádriceps femoral de velocistas y fondistas detectadas por 31 P-MRS]. CAR News (Colección de fascículos sobre entrenamiento de alto rendimiento y 12

13 proyectos de investigación asociados), Nº: 3, pp. 4-11, 1994, CAR/Sandoz Sport Research, Sant Cugat del Vallés. 87. González de Suso, J.M., Bernús, G., Alonso, J., Alay, A., Capdevila, A., Gili, J. [Desarrollo y caracterización de un ergómetro para estudiar la bioenergética del músculo quádriceps humano]. CAR News (Colección de fascículos sobre entrenamiento de alto rendimiento y proyectos de investigación asociados), Nº: 4, pp. 4-11, CAR/Sandoz Sport Research, Sant Cugat del Vallés. 88. Alonso, J., González de Suso, J.M., Bernús, G., Prat, J.A., Arús, C. [Resonancia magnética nuclear, metabolismo energético muscular y deporte] CAR News (Colección de fascículos sobre entrenamiento de alto rendimiento y proyectos de investigación asociados), Nº: 5 pp. 4-11, CAR/Sandoz Sport Research, Sant Cugat del Vallés. 89. González de Suso, J.M., Alonso, J., Bernús, G., Pujol, P., Prat, J.A., Arús, C. [Na utilizaçao da Ressonáncia magnética no Estudo do Metabolismo Energético em Desportistas]. Revista Portuguesa Medicina Desportiva 12: , González de Suso, J.M., Alonso, J., Bernús, G., Pujol, J., Gili, J., Capdevila, A., Prat, J.A., Arús, C. Aplicación de la imagen y de la espectroscopia por resonancia magnética nuclear a la valoración de factores que intervienen en el rendimiento deportivo. Revista de Entrenamiento Deportivo 8: 17-22, Remy C, Arus C, Ziegler A, Lai ES, Moreno A, Le Fur Y, Decorps M. In vivo, ex vivo, and in vitro one- and two-dimensional nuclear magnetic resonance spectroscopy of an intracerebral glioma in rat brain: assignment of resonances. J Neurochem. 62: , Cabanas ME, Alonso J, Arus C, Anderson ME, Westler WM, Markley JL. A versatile perifusion system for the NMR spectroscopy of bovine retina. Assignment of resonances and effect of ischemia. Exp Eye Res. 57: , Laurent, D., Bernús, G., Alonso, J., Lebas, J.F., Arús, C., González de Suso, J.M., Rossi, A. Efecto del entrenamiento sobre el metabolismo energético de los músculos del gemelo. CAR News (colección de fascículos sobre entrenamiento de alto rendimiento y proyectos de investigación asociados), Nº 1, pp. 4-11, 1993, CAR/Sandoz Sport Research, Sant Cugat del Vallés. 94. González de Suso, J.M., Alonso, J., Bernús, G., Alvarez, J. y Arús, C. Espectroscopía por resonancia magnética nuclear. Una metodología no invasiva para el estudio localizado del metabolismo energético muscular. Atletismo Español 447:56-60, Bernus G, Gonzalez de Suso JM, Alonso J, Martin PA, Prat JA, Arus C. 31P-MRS of quadriceps reveals quantitative differences between sprinters and long-distance runners. Med Sci Sports Exerc. 25: , Gonzalez de Suso JM, Bernus G, Alonso J, Alay A, Capdevila A, Gili J, Prat JA, Arus C. Development and characterization of an ergometer to study the bioenergetics of the human quadriceps muscle by 31P NMR spectroscopy inside a standard MR scanner. Magn Reson Med. 29: , González de Suso, J.M., Bernús, G., Alonso, J., Pujol, P., Prat, J.A. y Arús, C. Biochemical changes in skeletal muscle after a marathon race as assessed by phosphorus-31 nuclear magnetic resonance spectroscopy. Medicine, Exercise, Nutrition and Health 2:50-54,

14 98. Anderson ME, Markley JL, Arus C, Chobanian MC. A perifusion loop-gap resonator NMR probe for aerobic cell suspensions. Magn Reson Med. 29: , Moreno A, Rey M, Montane JM, Alonso J, Arus C. 1H NMR spectroscopy of colon tumors and normal mucosal biopsies; elevated taurine levels and reduced polyethyleneglycol absorption in tumors may have diagnostic significance. NMR Biomed. 6: , Moreno A, Escrich E, Prats M, Benito N, Alonso J, Arus C. Study of the ability of proton nuclear magnetic resonance spectroscopy of human plasma to differentiate between controls and breast cancer patients. Oncology 50: , Laurent D, Bernus G, Alonso J, Lebas JF, Arus C, Gonzalez de Suso JM, Rossi A. Effect of training on the calf muscle energy metabolism. A 31P-NMR study on four elite downhill skiers challenged with a standardized exercise protocol. Int J Sports Med. 13: , Alonso J, Arus C, Westler WM, Markley JL. Two-dimensional spectra of intact tissue: homonuclear Hartmann-Hahn spectroscopy provides increased sensitivity and information content as compared to COSY. Magn Reson Med. 15: , Alonso J, Arus C, Westler WM, Markley JL. Two-dimensional correlated spectroscopy (COSY) of intact frog muscle: spectral pattern characterization and lactate quantitation. Magn Reson Med. 11: , de Llorens R, Arus C, Pares X, Cuchillo CM. Chemical and computer graphics studies on the topography of the ribonuclease A active site cleft. A model of the enzyme-pentanucleotide substrate complex. Protein Eng. 2: , Arus C, Westler WM, Barany M, Markley JL. Observation of the terminal methyl group in fatty acids of the linolenic series by a new 1H NMR pulse sequence providing spectral editing and solvent suppression. Application to excised frog muscle and rat brain. Biochemistry 25: , Arus C, Barany M. Application of high-field 1H-NMR spectroscopy for the study of perifused amphibian and excised mammalian muscles. Biochim Biophys Acta. 886: , Bárány, M. y Arús, C. Lactic acid production in intact muscle, as followed by 13 C and 1 H nuclear magnetic resonance, in"human muscle power", Human Kinetics, pp Human Kinetics Publishers, Champaign, IL, USA, 1986, 108. Venkatasubramanian PN, Arus C, Barany M. Two-dimensional proton magnetic resonance of human muscle extracts. Clin Physiol Biochem 4: , Barany M, Chang YC, Arus C. Effect of halothane on the natural-abundance 13C NMR spectra of excised rat brain. Biochemistry 24: , Barany M, Arus C, Chang YC. Natural-abundance 13C NMR of brain. Magn Reson Med. 2:289-95, Barany M, Chang YC, Arus C, Rustan T, Frey WH 2nd. Increased glycerol-3- phosphorylcholine in post-mortem Alzheimer's brain. Lancet i:517, Arus C, Chang YC, Barany M. The separation of phosphocreatine from creatine, and ph determination in frog muscle by natural abundance 13C-NMR. Biochim Biophys Acta 844:91-93,

15 113. Chang YC, Arus C, Barany M. Characterization of the broad resonance in 31P NMR spectra of excised rat brain. Physiol Chem Phys Med NMR 17: , Arús, C., Chang, Y.-C. y Bárány, M. N-acetylaspartate as an intrinsec thermometer for 1 H NMR of brain slices. Journal of Magnetic Resonance 63: , Arus C, Yen-Chang, C, Barany M. Proton nuclear magnetic resonance spectra of excised rat brain. Assignment of resonances. Physiol Chem Phys Med NMR 17:23-33, Arús, C., Bárány, M., Westler, W.M. y Markley, J.L. 1 H NMR of intact tissues at 11,1 T. Journal of Magnetic Resonance 57: , Arus C, Barany M, Westler WM, Markley JL. 1H NMR of intact muscle at 11 T. FEBS Lett. 165: , Arus C, Barany M, Westler WM, Markley JL. Proton nuclear magnetic resonance of human muscle extracts. Clin Physiol Biochem 2:49-55, Arus C, Paolillo L, Llorens R, Napolitano R, Cuchillo CM. Evidence on the existence of a purine ligand induced conformational change in the active site of bovine pancreatic ribonuclease A studied by proton nuclear magnetic resonance spectroscopy. Biochemistry 21: , Arús, C., Nogués, M.V. y Cuchillo, C.M. Preparative purification and group separation of mono and dinucleotides by combining charge transfer and affinity chromatography. Journal of Chromatography 237: , Arus C, Paolillo L, Llorens R, Napolitano R, Pares X, Cuchillo CM. 1H-NMR studies on the binding subsites of bovine pancreatic ribonuclease A. Biochim Biophys Acta 660: , Pares X, Llorens R, Arus C, Cuchillo CM. The reaction of bovine pancreatic ribonuclease A with 6-chloropurineriboside 5'-monophosphate. Evidence on the existence of a phosphatebinding sub-site. Eur J Biochem 105: , Pares X, Arus C, Llorens R, Cuchillo CM. The specificity of the interaction of bovine pancreatic ribonuclease A with natural and halogenated purine nucleotides. Biochem J. 175:21-27,

16 Annex 2 Research support received by Carles Arús (full list) 1. Transforming Magnetic Resonance Spectroscopy into a Clinical Tool (TRANSACT), EU FP7-PEOPLE-2012-ITN Project number , 1/3/2013-1/3/2017, Coordinator (Sabine van Huffel (BE), PI for the UAB partner: Carles Arús. 2. Improvement of Magnetic Resonance based Molecular Imaging strategies for brain cancer diagnosis and therapy response monitoring (MARESCAN), SAF , MICINN, 1/1/12-12/31/14, PI: Carles Arús. 3. Dynamic Nuclear Polarizer (DNP). UNAB08-4E-004, MICINN, 2009, PI Carles Arús 4. [Grup d Aplicacions Biomèdiques de l Espectroscòpia de Ressonància Magnètica Nuclear] (GABERC), Generalitat de Catalunya, 2009/SGR-00926, 10/ /2012, PI Carles Arús. 5. Phenotype and molecular imaging of brain cancer progression by MRS/MRI in murine models. Translational application to humans (PHENOIMA). SAF , MICINN, 1/1/09-12/31/11. PI Carles Arús. 6. [Imagen multiparamétrica de la competencia vascular] (MULTIMAG). Comunidad de Madrid (S-BIO/0170/2006), 1/1/ /12/2010 PI: Sebastián Cerdán (role CA, head of participating group). 7. Gene interaction networks and models of cation homeostasis in Saccharomyces cerevisae (Translucent). Ministerio de Educación y Ciencia. GEN C2-1-E/SYS, IP Joaquin Ariño (role CA, participating scientist). 8. Director of a CIBER-BBN Research Group (GABRMN-UAB; CIBER-BBN group CB ) of the Networking Research Center on Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN, Instituto de Salud Carlos III (ISCiii). 01/01/06-12/31/13 (renewable for 4 year periods). 9. Agent-based distributed decision support system for brain tumour diagnosis and prognosis (HealthAgents). EU project IST , 1/1/ /12/2008 Poject Coordinator Magí Lluch (MicroArt). Role CA, head of UAB partner. 10. [Mejora del diagnóstico y de la valoración pronóstica de tumores cerebrales humanos in vivo. Modelos animales y celulares para la metabolómica de la progresión tumoral. Fase 2] (MEDIVO2). Ministerio de Educación y Ciencia, SAF , 12/ /2008, PI: Carles Arús. 11. [Grup d Aplicacions Biomèdiques de l Espectroscòpia de Ressonància Magnètica Nuclear] (GABERC), Generalitat de Catalunya, Convocatòria de Suport als Grups de Recerca de Catalunya, 2005/SGR /12/ /12/2008. PI: Carles Arús. 12. [Espectrómetro de Resonancia Magnética Nuclear con imán horizontal de 7 Teslas y diámetro de 30 cm para imaginería y espectroscopia in vivo de pequeños animales (rata, 16

17 ratón, conejo]. Ministerio de Educación y Ciencia (Infraestructura Científico-Tecnológica FEDER), UNAB , 2005, PI: Carles Arús. 13. [Xarxa Temàtica sobre aplicacions biomèdiques de la Ressonància Magnètica]. Generalitat de Catalunya, , PI: Carles Arús. 14. Web accessible MR decision support system for brain tumour diagnosis and prognosis, incorporating in vivo and ex vivo genomic and metabolomic data (etumour). EU project FP LIFESCIHEALTH , 1/2/ /6/2009. Project Coordinator Bernardo Celda (Universitat de Valencia). Role CA, head of UAB partner. 15. [Mejora del diagnóstico y de la valoración pronóstica de tumores cerebrales hunanos in viovo y en modelos animales de la patología] (MEDIVO). MCYT SAF , 1/2/ /11/2005. PI: Carles Arús. 16. International Network for pattern recognition of tumours using magentic resonance (INTERPRET). EU project IST , 1/1/ /12/2002. Project Coordinator: Carles Arús. 17. [Grup d Aplicacions Biomèdiques de l Espectroscòpia de Ressonància Magnètica Nuclear] (GABERC). Generalitat de Catalunya, Convocatòria de Suport als Grups de Recerca de Catalunya, 2001/SGR-00194, 10/02/ /12/2004. PI: Carles Arús. 18. [Aplicaciones clínicas de la espectroscopía de resonancia magnética nuclear: 1. Desarrollo de un sistema experto para la diagnosis, prognosis y seguimiento de la respuesta a la terapia en tumores cerebrales humanos. 2. Mecanismo bioquímico y utilidad clínica de la suplementación dietaria con creatina], CICYT SAF , 1/6/1999-1/6/2002. PI: Carles Arús. 19. A decission support tool for classifying brain lesions using MRI/MRS. Royal Society, , PI A.R. Tate (UK). 20. [Análisis mediante reconocimiento de patrones in vitro e in vivo de espectros de RMN de tumores cerebrales humanos. Aplicaciones diagnósticas]. Ministerio Educación y Cultura. Acción integrada Hispano-Británica, HB , , PI: Carles Arús (ES) and John R. Griffiths (UK). 21. [Triglicéridos como marcadores de hipoxia y de necrosis en tumores cerebrales. Detección in vivo por espectroscopía de RMN]. Ministerio Educación y Cultura, Acción Integrada Hispano-Francesa HF PI: Carles Arús (ES) and Chantal Rémy (FR). 22. [Triglicéridos como marcadores de hipoxia y de necrosis en tumores cerebrales. Detección in vivo por espectroscopia de RMN]. Ministerio Educación y Cultura. Acción Integrada Hispano-Francesa HF , PI: Carles Arús (ES) and Chantal Rémy (FR). 23. [Desarrollo de las aplicaciones clínicas de la espectroscopia de resonancia magnética nuclear (MRS) como técnica no invasiva para el estudio de la patología tumoral cerebral y la fisiología muscular]. CICYT SAF , 26/04/ /04/1999. PI: Carles Arús. 17

18 24. Pattern recognition and neural network processing of in vivo and in vitro 1 H NMR spectra of human brain tumors for diagnostic applications. Ministerio de Educación y Ciencia / British Council. Proyecto de colaboración Hispano-Británico HB , 04/ /1996. PI: Carles Arús (ES) and John R. Griffiths (UK). 25. [Desarrollo de protocolos de interés diagnóstico mediante espectroscopia de resonancia magnética nuclear. Aplicación al estudio del metabolismo de tejidos excitables y a la búsqueda de marcadores tumorales]. CICYT SAF CO2-01, PI: Carles Arús. 26. Cancer and brain disease characterization and therapy assessment by quantitative magnetic resonance spectroscopy. EEC BIOMED 1 Concerted Action. (Unión Europea) Re. PL , Project Coordinator Franca Podo Istituto Superiore di Sanità (IT), Carles Arús PI of partner UAB. 27. [Estudio por espectroscopia de RMN monodimensional (1D) y bidimensional (2D) de biopsias de tumores cerebrales y de colon]. Proyecto concertado INSERM-CSIC, PI: Carles Arús (ES) and Michel Décorps (FR). 28. [Construcción y puesta a punto de una antena de superficie para la obtención de espectros de RMN de 1 H de tumor de colon humano in vivo. Asignación del patrón espectral observado en tumores cerebrales y de colon]. Acción Integrada Hispano-Francesa HF-162B, PI: Carles Arús (ES) and Michel Décorps (FR). 29. Two-dimensional NMR analysis of excitable tissue. NATO Collaborative Research Grant CRG , PI: Carlos Arús (ES) y John L. Markley (USA). 30. [Obtención de patrones metabólicos tisulares mediante espectroscopia bidimensional de resonancia magnética nuclear (RMN-2D)]. DGICYT PB , PI: Carles Arús. 31. [Estudio del metabolismo muscular en atletas de alto nivel mediante espectrometría de resonancia magnética nuclear]. Acción Integrada Hispano-Francesa HF-227, PI: Carles Arús (ES) and Jean François Le Bas (FR). 32. [El estudio del metabolismo muscular en atletas de alto rendimiento mediante espectroscopia de Resonancia Magnética Nuclear], "Sandoz Sport Research Project", Sandoz (actualmente Novartis), PI: Joan Antoni Prat (Centre d Alt Rendiment Esportiu de Sant Cugat, CAR, ES), Carles Arús, PI of the UAB partner. 33. [Aplicaciones biomédicas de la espectroscopia de resonancia magnética nuclear]. DGICYT PB , PI: Carles Arús. 34. [Metabolisme en teixits intactes estudiat per ressonància magnètica nuclear]. CIRIT (Generalitat de Catalunya), PI: Carles Arús. 35. [RMN de Tejidos in vivo]. Comité Conjunto Hispano-Norteamericano para la Cooperación Científica Científica y Tecnológica, CCA , PI: Carles Arús (ES) and John L. Markley (USA). 18

19 36. Multinuclear NMR studies of human muscle. Muscular Dystrophy Association (USA), 7/1982-9/1985. PI: Michael Bárány. 19

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