Centro de Investigación Biomédica En Red de Salud Mental

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1 2010 ANNUAL REPORT

2

3 Centro de Investigación Biomédica En Red de Salud Mental Unión Europea Instituto de Salud Carlos III Fondo Europeo de Desarrollo Regional Una manera de hacer Europa

4 INDEX Presentation...5 Introduction... 6 CIBERSAM Innovation... 9 Internal Organization Scientific Activity Calls and Projects...18 Transversal Areas Figures and News...45 CIBERSAM in figures CIBERSAM in the News Research Areas Depression Schizophrenia Bipolar Disorder Other Mentals Disorders Groups Centro de Investigación Biomédica En Red de Salud Mental

5 PRESENTATION Introduction...5 CIBERSAM Innovation...9 Internal Organization... 10

6 2010 ANNUAL REPORT Introduction Three years after its establishment, the Mental Health CIBER (CIBERSAM) has largely attained the objectives set at the beginning of our project s course. This annual report shows how in a short period of time we have succeeded in that the main mental health research groups of our country participate in joint objectives. It also bears witness to the fact that, apart from a national collaboration between clinical and basic groups, the common effort has resulted in our internationalization via the cooperation with other European mental health networks, especially through initiatives funded by the 7th Framework Programme. In 2010, we have changed our working strategy per areas to a set of pathology programmes, enhancing and adding cross areas. This means that, although the groups carry out research not directly embedded in the CIBER s mission, only the collaborative elements, those that take advantage from CIBERSAM s structure, will be fostered. In the 2011 annual strategy, we go on identifying evaluable indicators for each one of the areas, platforms, joint projects and training, all of them being more and more ambitious in spite of the economic context and the granted funds. Some platforms have steadied themselves, as for instance the Bank of Instruments, which is providing a good service to the intramural and extramural scientific community, and the DNA platform, which is gathering a considerable amount of samples and this makes us highly competitive among international consortia. The GRIDSAM tool, which allows entering data in multiple centre projects, has been transformed into a grid system that makes a centralized capture of data, allowing thus a more efficient data mining. This system is already being used in multiple centre projects and allows the researchers to have an easier access to an important amount of data. It not only facilitates the data management, but also can be used to carry out concept tests that later on can be checked through studies designed for those purposes. We are particularly proud of our increasingly prolific participation in European projects within programmes such as the 7th Framework Programme, DG-SANCO, Marie Curie, IMI, among others. This year we have obtained several projects of the ERANET-Neuron mental health call. After having impelled the Madrid Statement, available in our website (www.cibersam.es) and in our 2009 annual report, we have succeeded in having the European Commission launch a call to elaborate the European Mental Health Road Map, with the aim to integrate and coordinate the research done on this field in all the European Union countries. By the time we were preparing this annual report, we have been informed that the CIBERSAM-led consortium, directed by Josep Maria Haro, has been chosen to carry out that road map for the next three years. Due to its extremely strategic importance, this excellent news represents the best European project granting, since the Road Map will determine the priority and financing lines of the European Commission concerning mental health in the years to come. Our coordinator of European programmes, José Luis Ayuso, has played a key role in the achievements of this area. 6

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8 2010 ANNUAL REPORT Being aware of the need to communicate our findings to society, one of the cross areas that we have fostered is the institutional relations and communication area, to which Dr. Miquel Bernardo has been appointed. During 2010, we have intensified our relationship with families and patients associations. We organized the CIBERSAM Social Forum, which gathered the most relevant associations of families and patients along with CIBERSAM researchers. In this meeting we had the opportunity to explain CIBERSAM s activities and to have a first-hand report by the associations about the perceived needs and areas to be improved in mental health research. In 2010, CIBERSAM frequently appeared in the media. We have constantly improved our website so as to make it more intuitive and to provide the users, network members as well as CIBERSAM outsiders, with more information. As for the management area, the quality accreditation has been renewed for all administrative procedures in purchasing and staff management. Moreover, we have improved a software allowing the people in charge of administration to do a non-centralized management of the groups projects and budgets, with real time monitoring and limiting the use of paper only to legally compulsive cases. Likewise, this software facilitates the automated elaboration of annual reports as well as the annual evaluation of the CIBERSAM groups. It is evident that there are many challenges ahead and that the current context, with its budget limitations, makes it difficult to keep the cruising speed we had up to now. In spite of the decreasing public funding, we will only be able to progress with a higher efficiency in the scientific management of the granted funds. We must also actively look for other funding resources. This was an attained objective in 2010 due to the agreements reached with different private companies. Finally, we can only have a stable research structure through a dynamic model, away from the public research centre classic model of our country. For this purpose, it is necessary to facilitate, on the one hand, that the less productive groups and with a lesser added value to CIBER leave the consortium and, on the other hand, that those outside groups having enough credentials and willing to become members be included in our institution. The current economic crisis must strengthen us and we must turn this budget decrease into an opportunity to increase our efficiency, excellence, and alternative fund raising. It is only in this way that we will be able to keep the splendid cruising speed attained during our first three years. With no vertigo. Celso Arango López Scientific Director 8

9 Innovation in Cibersam Nowadays, the word innovation has become a magic word about which everybody wants to talk. In our field, it basically stands for the process that allows translating the object of our research into a genuine knowledge that brings improvements in the clinical practice and, therefore, in the mental health of our society and its citizens. With this view, in CIBERSAM we try to promote an innovation culture in all research areas. A good example would be the creation of a new programme of therapeutic innovation in which a large number of groups participates. This innovation process must be continuous. This continuity has allowed our institution to become a national reference in the short term and to transcend now to an international level. The creation or modification of useful products for society is directly connected to the mission and the perspective of our CIBER. In this Annual Report, at the end of each research group record, the main innovative contributions in 2010 are presented. CIBERSAM aims to generate a translation between clinic and knowledge fields such as Neuropharmacology, Genetics, Imaging, Epidemiology or Biochemistry, which results in a better understanding of mental disorders. In order to achieve this, we are totally aware that we must make a symbiosis with the private business sector. In line with this, since the consortium was created, 17 agreements have been reached between CIBERSAM and private companies. Innovation, transmission, and transference in relation with products as well as with processes as in the new therapeutic targets with a specific programme in our CIBER since 2010 are elements that must focus not only on searching molecules with new action mechanisms, but also on searching new diagnosis, detection, assessment and prognosis techniques, non pharmacologic therapeutic approaches or imaging technology. An example of all this would be the participation of CIBERSAM groups, for instance Dr. Artiga s, in the European initiative IMI to develop new therapeutic targets. This project is half sponsored by private companies and by the European Commission. The combination public-private sector is the most efficient way to turn ideas into patents and to obtain funds from the research that has been carried out. This is the philosophy of other countries that have increased their research budget, even in a situation of economical crisis, since they are convinced that this is the only way to generate wealth in the medium term. In 2010, the CIBERSAM groups achieved 5 patents, they did 53 clinical trials, and participated in 13 clinical guides. We are committed in going on innovating with the ultimate aim of having the feeling of being more useful to society and, thus, of doing what we really like. 9

10 2010 ANNUAL REPORT Internal Organization CIBERSAM, in accordance with its statutes, is governed and administered by the Board of Trustees and its Permanent Commission and the following managerial bodies: the Steering Committee, the Scientific Director, and the Management. The coordinating structure of CIBERSAM is set up to guarantee that it functions efficiently and facilitates the achievement of its planned goals. Such structure is divided into a scientific line and an economicadministrative line. Organization Chart: BOARD OF TRUSTEES SCIENTIFIC COUNCIL PERMANENT COMMISSION SCIENTIFIC DIRECTOR MANAGEMENT STEERING COMMITTE TECHNICAL UNIT AREA COORDINATOR TRAINING & MOBILITY COORDINATOR EUROPEAN PROGRAMMES COORDINATOR INSTITUTIONALS RELATIONS COORDINATOR QUALITY & INTERNAL EVALUATION COORDINATOR RESULTS & COMUNICATIONS COORDINATOR DATABASES COORDINATOR PLATFORMS COORDINATOR During the meeting of the Steering Committee held on August 2, 2010, the committee unanimously approved the replacement of Jerónimo Saiz by Miguel Bernardo Arroyo as Institutional Relations Coordinator. 10

11 Board of Trustees The Board of Trustees consists of three representatives from the Instituto de Salud Carlos III and a representative from each of the Consortium Institutions. The President of the Board of Trustees is the Director of the Instituto de Salud Carlos III and the Managing Director of the Consortium acts as the Secretary of the Board. The Board of Trustees exercises general control over the Consortium; it designates and appoints the members of the Scientific Council, the Permanent Commission and the Scientific Director of CIBERSAM. Members of the Board of Trustees: Instituto de Salud Carlos III: Jerónimo Navas Palacios (Presidente del Consejo) Instituto de Salud Carlos III: Joaquín Arenas Barbero (Vicepresidente del Consejo) Instituto de Salud Carlos III: Miguel A. Cabo López Cibersam. Managing Director: Manuel Sánchez Delgado (Secretario del Consejo) Cibersam. Scientific Director: Celso Arango López Consejo Superior de Investigaciones Científicas: Paola Bovolenta Nicolao Fundación IDIBELL: Emilià Pola Robles Fundación Hospital Universitario Marqués de Valdecilla: Luis Carmelo Anchoriz Tejedor Fundación para la Investigación Docencia Sant Joan de Deu: Emili Bargallo Angerri Fundación Vasca de Innovación e Investigación Sanitarias: Carmen Garaizar Axpe Hermanas Hospitalarias Sagrado Corazón de Jesús - Benito Menni: Josep Treserra Torres Hospital Clínico y Provincial de Barcelona: Ramón Gomis de Barabara Instituto Aragonés de Ciencias de la Salud: Esteban de Manuel Keenoy Instituto de Investigación Hospital Santa Cruz y San Pablo: Jaume Kulisevsky Servicio Madrileño de Salud: Elena Andradas Aragonés Universidad Complutense de Madrid: Milagros Palacios Alarcón Universidad de Barcelona: Xavier Meneses Martínez Universidad de Cádiz: Francisco Antonio Macías Domínguez Universidad de Cantabria: José Carlos Gómez Sal Universidad de Granada: María Dolores Suárez Ortega Universidad de Oviedo: Santiago García Granda Universidad de Valencia: Ana María Cortés Herreros Universidad del País Vasco: Antonio Romo Soler 11

12 2010 ANNUAL REPORT Permanent Commission The Permanent Commission is comprised of the President of the Board of Trustees, the Scientific Director of the Consortium, the Managing Director of the Consortium, who acts as Secretary, and four representatives of the Consortium Institutions. The Permanent Commission evaluates the activities of the Consortium and reviews and adjusts budgets, accounts and other reports to be approved by the Board of Trustees. Members of the Permanent Commission CIBERSAM. Managing Director: CIBERSAM. Scientific Director: Fundación para la Investigación y Docencia Sant Joan de Deu: Fundación Vasca de Innovación e Investigación Sanitarias: Instituto de Salud Carlos III: : Universidad de Granada: Universidad de Oviedo: Manuel Sánchez Delgado (Secretario) Celso Arango López Emili Bargallo Angerri Carmen Garaizar Axpe Joaquín Arenas Barbero María Dolores Suárez Ortega Santiago García Granda 12

13 External Scientific Advisory Committee This committee provides general scientific advice and support to the Board of Trustees. Its members are composed of international caliber scientists in the field of health services whose distinguished professional or scientific careers are especially relevant to the objectives of CIBERSAM. The committee has a President and at least four additional members, all of them appointed by the President of the Board of Trustees. The External Scientific Advisory Committee informs and advises the Board of Trustees on the characteristics of scientific and technical research occurring at national and international levels and on its possible impact on the operation of CIBERSAM. Its main functions are: Advising with respect to scientific policy guidelines and institutional relationships Reviewing the proposed Strategic Plan, the proposed Annual Scientific Reports, and the Annual Action Plans Reporting on the adequacy of programs, resources, and capabilities for the purposes of the consortium Advising on the strategy of transferring research results Advising on the policy relating to scientific staff incorporation Reporting on the creation of research programs MEMBERS INSTITUTION POSITION Jim Van Os Guy Goodwin Michael Hamon María Ron Marion Leboyer Maastricht University, Holland Department of Psychiatry, University Of Oxford, Warneford Hospital, Oxford, United Kingdom Institut National de la Santé et de la Recherchev Médicale/Université Pierre et Marie Curie. Paris, France Institute of Neurology, University College London, Queen Square, London, United Kingdom Groupe Henri Mondor-Albert Chenevier, Pôle de Psychiatrie, Créteil, Paris, France President of the External Scientific Comiitee Member Member Member Member 13

14 2010 ANNUAL REPORT Steering Committee The Steering Committee of CIBERSAM is the body responsible for carrying out managerial tasks. It is a collegiate body that ensures the development of CIBERSAM, meeting the needs of its member groups and their strategic objectives. Members of the Steering Committee: Dr. Celso Arango Dr. Francesc Artigas Dr. Victor Pérez Dr. Eduard Vieta Dr. Julio Sanjuán Dr. Antonio Lobo Dr. Ángel Pazos Dr. Josep María Haro Dra. Ana María González-Pinto Dr. Manuel Sánchez Scientific Director Coordinator of the Depression Area Coordinator of the Bipolar Disorder Area Coordinator of Schizophrenia Area and Common Databases Coordinator of Other Mental Disorders Area Coordinator of Training and Mobility Coordinator of Platforms Quality Coordinator Managing Director Technical Unit The headquarters of CIBERSAM s Technical Unit are in Madrid, at 46 Doctor Esquerdo Street, in the Gregorio Marañón Hospital, Government Pavillion, 1st floor. Its mission tasks include an appropriate staff management, payments to vendors, project coordination, diffusion and communication, asset management, administrative hiring, negotiation of agreements, and lastly, the facilitation of dialogue among the geographically dispersed research groups and the administrative bodies of CIBERSAM. Manuel Sánchez Delgado Begoña Sáenz de Tejada Paula López Amaya Rivera Algarrada Sara García Rodríguez Elena Cortés Leclerc María Miret García Managing Director Technical Unit Administration Human Resources European Projects - Communication Scientific Secretary Communication* *Dropped out on September 15th,

15 Cibersam Consortium Eight Autonomous Regions taking part through the following institutions and/or centres Funded by: Unión Europea Fondo Europeo de Desarrollo Regional Una manera de hacer Europa 15

16 2010 ANNUAL REPORT Cibersam Groups principal investigator institution city code área Dr. Celso Arango López Hospital General Universitario Madrid G01 Other mental Gregorio Marañón disorders Dr. Francesc Artigas Pérez Instituto de Investigaciones Biomédicas Barcelona G02 Depression Dr. Jose Luis Ayuso Mateos Hospital Universitario La Princesa Madrid G03 Bipolar disorder Dr. Miquel Bernardo Arroyo Hospital Clínic i Universitari de Barcelona Barcelona G04 Schizophrenia Dr. Julio Bobes García Universidad de Oviedo Oviedo G05 Bipolar disorder Dr. Jorge A. Cervilla Ballesteros Universidad de Granada Granada G06 Depression Dr. Manuel Desco Menéndez Hospital General Universitario Madrid G07 Schizophrenia Gregorio Marañón Dra. Lourdes Fañanás Saura Universidad de Barcelona Barcelona G08 Depression Dr. Javier Garzón Niño Instituto Cajal, CSIC Madrid G09 Depression Dra. Ana Mª. Glez-Pinto Arrillaga Hospital Santiago Apóstol Vitoria G10 Bipolar disorder Dr. Josep M. Haro Abad Fundació Sant Joan de Déu Barcelona G11 Schizophrenia Dr. Juan Carlos Leza Cerro Universidad Complutense Madrid G12 Other mental disorders Dr. Antonio Lobo Satué Hospital Clínico Universitario Zaragoza G13 Other mental disorders Dr. Juan José López-Ibor Aliño Hospital Clínico San Carlos Madrid G14 Other mental disorders Dr. Peter McKenna Benito Menni Complex Assistencial Barcelona G15 Schizophrenia Dr. Javier Meana Martínez Universidad del País Vasco Leioa, G16 Depression Bizkaia Dr. José Manuel Menchón Magriñá Hospital Universitari de Bellvitge Barcelona G17 Other mental disorders Dr. Juan Antonio Micó Segura Universidad de Cádiz Cádiz G18 Bipolar disorder Dr. Tomás Palomo Álvarez Hospital Universitario 12 de Octubre Madrid G19 Schizophrenia Dr. Ángel A. Pazos Carro Universidad de Santander Santander G20 Depression Dr. Víctor Pérez Solá Hospital de la Santa Creu i Sant Pau Barcelona G21 Depression Dr. Jerónimo Sáiz Ruiz Hospital Universitario Ramón y Cajal Madrid G22 Other mental disorders Dr. Julio Sanjuán Arias Universidad de Valencia Valencia G23 Schizophrenia Dr. Rafael Tabarés Seisdedos Universidad de Valencia Valencia G24 Bipolar disorder Dr. Eduard Vieta Pascual Hospital Clínic i Universitari de Barcelona Barcelona G25 Bipolar disorder Dr. José Luis Vázquez-Barquero Hospital Universitario Marqués de Valdecilla Santander G26 Schizophrenia 16

17 scientific ACTIVITY Calls and Projects Transversal Areas

18 2010 ANNUAL REPORT Calls and Projects Among the activities developed by CIBERSAM, there are innovation initiatives that contribute to carrying out a quality research. In this area, it is noteworthy the launch of funding calls for coordinated projects fostering cooperation between the consortium groups. In 2010, the following internal calls were carried out: Intensification Call, Translational Intramural Call, Funding call to develop projects within the Neuroimaging Platform, Call of grants for the Bank of Instruments research projects. Intensification Call This call, approved in CIBERSAM s annual meeting held on October 24th 2009, finances up to 36 months/year. It was published on October 27th 2009 and its aim is to free the researcher or the scholar from the assistance workload. According to the resolution published on December 9th 2009, the list of intensified CIBERSAM researchers for the year 2010 is as follows: Dr. Celso Arango López Dra. Lourdes Fañanás Saura Dr. Víctor Pérez Sola 18

19 Translational Intramural Call Always within the frame of development and support to scientific activities, CIBERSAM has agreed to finance intramural projects of clinical and translational nature. The funds are used as a complement to projects financed by public institutions in competitive calls as well as for projects specifically addressed to this call, without complementary fundings. In CIBERSAM, the studies on mental health aim to lead a translational tendency that allows innovative results. The innovative, translational, and collaborative nature of the project to be developed is one of the valued aspects when selecting projects. In this context, 16 projects were submitted to the translational intramural call on September 23rd All the projects had high quality standards and 6 of them were granted funds for the year 2011 (resolution on December 28th 2010). Resolution to the translational intramural projects call: Project MR GROUPS Granted amount Use of antidepressants in the last decade and its relation to mortality and suicide-related events, with special focus on children and adolescents JL Ayuso G03-G01-G21 55,000 Metylphenidate immediate release in the initial treatment of symptoms of acute mania JL Ayuso G03-G5-G21 53,000 Cortical activity in schizophrenia: a translational study on the pharmacological response to hallucinations. J. Sanjuán G23-G02-G21-G15 39,000 Metabotropic glutamate receptors 2/3 (mglur2/3) as drug targets to improve cognitive impairment in schizophrenia. F. Artigas (A. Castañé) G02-G20 39,000 Depression and chronic pain comorbidity: impact on neurogenesis and cognition. JA Micó G18-G12-G07-G09 43,000 Study of gene-environment interactions in schizophrenia: vulnerability and severity. C. Arango G01-G04-G23-G05 74,000 19

20 2010 ANNUAL REPORT Funding call to develop projects within the Neuroimaging Platform With the aim to promote the development and application of quantitative analysis techniques in Neuroimaging within CIBERSAM, the Neuroimaging Platform received a 63,000 grant to finance research projects throughout This call is addressed to all CIBERSAM groups. The projects can be jointly done by several research teams and, in general, the multiple centre (multiple group) nature is highly valued. The participation of external groups is also taken into consideration if at least one of the participants and the coordinating group belong to CIBERSAM. The projects must fit into the working lines that are of interest for the whole CIBERSAM. The projects orientation must be technical, methodological, and eminently practical, focused on the development, implementation, and validation of analysis and image processing techniques applicable to neurobiological research. Four out of five projects were funded with the call published on October 6th The resolution of the 2010 call of the Neuroimaging Platform took place on December 21st

21 Title Research team Granted funds Comparative analysis of segmentation tools for the estimation of sulcal depth in brain MR images Validation and Implementation of Morphomety technique based on sources for its application in the field of mental diseases Software programming to calculate connectivity maps at voxel level using the spectrum measurements and minimizing the physiological noise Development of a software tool for the automated processing of SPM studies on fmri in animals and for the adaptation of non-linear and multiple variable methods in SPM studies. IP J Janssen G01 E Canales G15 R Salvador G15 Y Alemán G07 S Reig G07 IP G Monté Rubio G15 E Canales G15 P Salgado G15 E Pomarol G15 P McKenna G15 J Sanjuán G23 G García-Martí G23 V Iglesia G23 IP R Salvador G15 E Canales G15 M Anguera G15 S Reig G07 Y Aleman G07 IP E Berrocoso G18 JA Micó G18 S Torres G18 M Desco G07 Y Aleman G07 M Soto-Montenegro G07 C Chavarrías G07 M Benito G07 M Martínez UC3M V Gómez UC3M M Cassía UC3M 17,500 4,900 19,600 21,000 21

22 2010 ANNUAL REPORT Call of grants for the Bank of Instruments research projects On the 28th September 2010, CIBERSAM launched the financing call for research projects in the Bank of Instruments (BICIBERSAM). The research projects liable to receive grants must be within some of the following working lines developed by BICIBERSAM: Instruments for diagnosis evaluation. Instruments for symptomatology evaluation. Instruments for neuropsychology evaluation. Instruments for disability assessment. Specific instruments to be applied to childhood/adolescence. Specific instruments to be applied to special populations. Instruments for dual pathology assessement. 22

23 This call s resolution was published on December 22nd The following 9 projects, out of 31, received funds for 2011: TITLE Researcher Group Validation of the Bermond-Vorst alexithymia questionnaire for Spanish population with severe mental disorder Ana González-Pinto G10 Factorial structure, convergent validity, discrimination capacity and change sensitivity in the Spanish version of the Remission from Depression Questionnaire (RDQ) Víctor Pérez Sola G21 Relation between the psychometric evaluation of psychosocial performance and quality of life in euthymic bipolar patients Eduard Vieta G25 Evaluation of change sensitivity in a psychosocial performance scale in bipolar patients (FAST) Eduard Vieta G25 Creation of a screening test for cognitive deterioration in alcoholism Gabriel Rubio Valladolid G19 Development of a new scale for dementia stages: practicability, reliability, and validity Antonio Lobo G13 Validation of the self-injurious thoughts and behaviours interview (SITBI) in Spanish population with suicidal conduct Enrique Baca García G22 Study on the creation and validation, for the Spanish population, of a scale to measure the degree of severity of drugs consumption in dual pathology patients Iris Baños Yeste G11 Spanish validation of a series of films to induce emotions Enrique Álvarez Martínez G21 23

24 2010 ANNUAL REPORT Transversal Areas Transversal Areas are tools that allow approaching the objectives planned in CIBERSAM. These areas were created drawing from the REM-TAP experience, at the origin of the Mental Health CIBER, with a view to empower the research groups that shape this network centre by providing them with more means, by facilitating the accessibility and by fostering their collaboration. Transversal AREAS Training and Mobility European Programmes and International Relations Institutional Relations Quality and Internal Evaluation Results and Communication Common Data Bases Platforms AREA coordinator Dr. Ángel Pazos Carro (G20) Dr. José Luis Ayuso Mateos (G03) Dr. Jerónimo Saiz (G22) * Dr. Miquel Bernardo (G04) Dra. Ana González-Pinto (G10) Dr. Julio Bobes García (G05) Dr. Juan Antonio Micó Segura (G18) Dr. Julio Sanjúan Arias (G23) Dr. Josep Mª Haro Abad (G11) * The Steering Committee, at the meeting held on the 2nd August 2010, unanimously approved that Miquel Bernardo should substitute Jerónimo Saiz as Coordinator of Institutional Relations. 24

25 Training and Mobility One of the objectives of CIBER of Mental Health is to improve the training of mental health researchers in this country. It is a necessary goal if we want to have well-trained professionals in the field of Mental Health and the Neurosciences. We at CIBERSAM believe that the training, especially of young researchers, is a strategic investment. Accordingly, since the start of the network centre, a training programme has been organized that seeks to be a reference for training in Mental Health in this country. Ángel Pazos Carro Coordinator of Training and Mobility Area Training Programme Objectives One of the missions of CIBERSAM is to facilitate and improve the training capacity of its researchers. For this reason, CIBER of Mental Health provides, within its work strategies, a specific training programme aimed preferentially towards trainee researchers. 80% of the total Training budget and at least 70% of each group s budget must be devoted to priority courses and internships or placements with other CIBERs. The training programme includes the following priority objectives: Facilitate the training of young researchers and their access to new scientific and technological knowledge related to research. Enhance training activities, preferably in the strategic lines defined in the basic project of CIBERSAM. Contribute to the integration of all the groups of CIBER as per its structure. Identify new needs with respect to the in-house training of the CIBERSAM professionals which should be incorporated into the programme. Training Programme Activities In 2010, the following activities were completed as part of the training programme: Training courses which are related to various research areas of CIBER or which are of a more general character. In accordance with the funding rules and the approved prioritization for 2010, the training programme funded: As a first priority, programmes and courses offered by CIBERSAM itself, organized by its member groups or those others identified as of special interest. The course offerings are listed on the CIBERSAM website throughout the year. 25

26 2010 ANNUAL REPORT As a second priority, attendance at other courses related to subjects that the Programme has identified as of interest as they are subject matters which are in high demand by a significant part of the member groups: Applied Statistics for Medicine, Data Analysis and the Use of Specific Software, Research Methodology, Cognitive Therapy, Statistical Parametric Mapping (SPM), Approved Courses on the Handling Animals for Scientific Research and Courses for Operators or Supervisors of Radioactive Installation. Research Placements: in accordance with the funding rules approved in 2010, the Programme financed placements in other units of CIBER (hospitals, laboratories, specific units) or placements abroad for the purpose of learning techniques, instruments, strategic and diagnostic therapies, new approaches, etc. Curriculum Development and the corresponding Report regarding the development of CIBER s own Master and Postgraduate Studies in Mental Health Research. As discussed further below, in 2010, CIBERSAM designed a Studies Programme, selecting the participating Universities and establishing the performance standards, etc. Each of the Universities has begun the approval process. Training Courses With regard to the courses that were offered, the Programme established the following as priority courses: Courses organized by CIBERSAM itself: Jornada de Bancos de Tejidos Neurológicos y Salud Mental, Barcelona (Dr. Josep Mª Haro) Curso sobre Validación de cuestionarios, Barcelona (Dr. Josep Mª Haro) Curso intensivo de introducción a la investigación básica en Neurociencias, Madrid, (Dra. Lourdes Fañanás) Evaluación y Tratamiento de las alucinaciones auditivas en las Psicosis, Valencia, (Dr. Julio Sanjuán) Laboratorio de Ideas del CIBERSAM: Reunión semestral de presentación y discusión de resultados de investigación, Madrid (Dres. Juan C. Leza y Rafael Tabares) Introducción a la psicopatología y diagnóstico de la enfermedad mental, Barcelona (Dra. Lourdes Fañanás) 26

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