1 HECHO RELEVANTE AB-BIOTICS, S.A. 27 de Mayo de 2015 En cumplimiento de lo dispuesto en la Circular 9/2010 del Mercado Alternativo Bursátil y para su puesta a disposición del público como hecho relevante, por medio de la presente se pone a disposición del mercado la siguiente información relativa a AB-BIOTICS, S.A.: Se adjunta la presentación corporativa que utilizará la Compañía en el 11º Foro Medcap de empresas de mediana capitalización, organizado por Bolsas y Mercados Españoles los días 27 y 28 de mayo de Quedamos a su disposición para cuantas aclaraciones consideren oportunas. Atentamente, En Barcelona, 27 de Mayo de AB-BIOTICS, S.A. Sergi Audivert Brugué Miquel Àngel Bonachera Sierra
3 INDEX COMPANY OVERVIEW
4 COMPANY OVERVIEW MISSION AND VALUES HISTORY AB-Biotics was founded in 2004 at the Universitat Autònoma de Barcelona (UAB) with two technology platforms: Research in its own collection of 550 strains of probiotic bacteria Develop of advanced genetic tools for pharmacogenetics MISSION VISION AB-Biotics strives to improve health by developing products and providing services that help support healthy living and prevent diseases. AB-Biotics aspires to set a standard in the European biotechnology industry for both value and profitability.
5 COMPANY OVERVIEW CURRENT SNAPSHOT KEY FIGURES LOCATIONS AB-BIOTICS (GROUP) 2015 Patents filed 124 Products to Market 10 R&D Exp. As % of Rev 29% Employees (FTE) 31 GIRONA: Office and laboratory at Science Park of Universitat de Girona. Authorized genetic laboratory provided by the most advanced genotyping technology, capable of processing more than 20,000 samples/yr. PhD Scientists (FTE) Business Development team (FTE) International Presence markets Public company that aspires to establish state-of-art solutions that improve people s health. BARCELONA: Company Headquarters at Universitat Autonoma Barcelona Research Park.
6 MANAGEMENT TEAM Senior Management Team Carlos de Lecea MD, MBA, Managing Director (since Jan 2014) Former SVP of International Business Development at Ferrer International. Created 10 new affiliates from scratch and established a new network of joint-ventures in Europe and Latin America. Expanded the international business for the group from a marginal 3% to 55% of total revenues of the company. Started from 7 MM, currently represents over 450 MM in sales. Extended the distribution of products from 10 countries to 93 countries in all continents. Successful negotiations of over 200 deals. Miquel Angel Bonachera MoS, MBA, Co-Founder & Executive Director (since Apr 2004) Mr. Bonachera holds a degree in biochemistry from the Autonomous University of Barcelona and an MBA from ESADE Business School, focusing in finance. Miquel is co-founder, shareholder of AB-Biotics. He previously developed his career in the U.S. as a Researcher at the Vanderbilt Microarray Shared Resource at Vanderbilt University. Sergi Audivert MoS, MBA, Co-Founder & Executive Director (since Apr 2004) Mr. Audivert holds a degree in Science and Food Technology from the Autonomous University of Barcelona, a degree in Human Nutrition and Dietetics from the University of Barcelona and an MBA from ESADE Business School. Sergi is co-founder, shareholder of AB-Biotics. Prior to this he developed his career working as Scientific Manager at Medical Novartis.
7 COMPANY OVERVIEW CURRENT SNAPSHOT In company R&D for development of functional ingredients, mainly probiotics for application in the pharmaceutical industry. Best-in-class probiotic solutions in the market for a variety of therapeuctic areas. More than 40 concepts under development. Personalized medicine and pharmacogenetics. Team of 16 FTE (within 7 Ph.D.) dedicated to the development of pharmacogenetic tools. Our own laboratory ISO 9001 certified with capacity for analysis per year
8 INDEX COMPANY OVERVIEW BUSINESS DEVELOPMENT AND LICENSING ACTIVITIES
9 Time to market PARTNERING STRATEGY PARTNER DIVERSIFICATION: Risk and Life Cycle Management National champions Global distributors Niche leaders Deal scope
10 COMPANY LICENSING DEALS R&D for development of functional ingredients, mainly probiotics for application in functional foods and food supplements. Division dedicated to the development of advanced genetic tools for pharmacogenetics. The company has appropriate human and technical resources for conducting genetic analysis.
11 BUSINESS MODEL RESEARCH & DEVELOPMENT INTELLECTUAL PROPERTY LICENSING AND BUSINESS SUPPORT - Hit Screening. - In Vitro Models. - Animal Studies. - Industrial Scale-Up. - Clinical Studies. - International patent protection in over 32 countries. - Regional agreements for our patented strains and/ or products for specific channels and uses. - Regular business support helping with marketing mix strategy and product improvement.
12 INDEX PROBIOTICS TECHNOLOGY PLATFORM A BIG LEAP FORWARD IN THE PROBIOTIC SCIENCE
13 WHAT IS A PROBIOTIC? World Health Organization's 2001 definition of probiotics is "live micro-organisms which, when administered in adequate amounts, confer a health benefit on the host" The human microbiome consists of about 100 trillion microbial cells, outnumbering human cells 10 to 1. There are more than 3 millions microbial genes in our gut microbiota 150 times more genes than in the human genome. Microbiota, in total, can weigh up to 2,000 g. The mean weights of adult brain and liver are respectively 1,407 g and 1,561 g. More than 1,000 different known bacterial species can be found in human gut microbiota, but only 150 to 170 predominate in any given subject. The composition of gut microbiota is unique to each individual, just like our fingerprints. We are 90% microbe and 10% human
14 AB-BIOTICS COMPETITIVE ADVANTAGE IN PROBIOTICS AB Biotics owns a large collection of bacterial strains, collected from several places around the world that contains more than 550 different wild-type strains. 1st: Identify isolated areas in which the microbiota has been preserved across the years. 2nd:To obtain Lactic Acid Bacteria Strains from areas with low incidence of GI disease, immunity disorders, oral condition etc.. Little or no use of antibacterials and antifungals. Thus natural flora must hold the ground on their own LOW IBD AND LOW IMMUNITY DISORDERS INCIDENCE The lack of exposure to microbial has established an immunity tolerant disposition in human beings. Such exposure is still present in some communities through-out the world, giving hosts an improved health condition.
15 AB-BIOTICS COMPETITIVE ADVANTAGE IN PROBIOTICS AB Biotics owns a large collection of bacterial strains, collected from isolated places around the world that contains more than 550 different wild-type strains. Bringing diversity to the harmed, modern accomodated microbiota
16 PRODUCT PORTFOLIO PRODUCT PORTFOLIO CARDIO- METABOLIC PAEDIATRIC GASTRO- INTESTINAL ORAL CARE URO- GYNAECOLOGY Metablock Avantbise AB-Dentisani AB-INTIMUS WEIGHT MANAGEMENT RENAL DERMATOLOGY COUGH & COLD BONE HEALTH LipiGO PROBIO 65 AB-INMUNO AB-K BONE
17 INDEX COMPANY OVERVIEW NEUROPHARMAGEN
18 PHARMACOGENETICS Personalized medicine means tailoring treatments to the individual characteristics of patients. CURRENT MODEL Same diagnosis, Same prescription PERSONALIZED MEDICINE Same diagnosis + Genetic analysis Increased drug dose BENEFITS OF THE ANALYSIS 1. Decreased adverse reactions Standard dose Reduction in drug dose Drastic reduction of dose 2. Safer drug selection 3. Better treatment compliance 4. Higher probability of therapeutic success 5. Reduction of health care costs Changes in treatment according to: age, height, weight, gender, biochemistry (creatinine). Genetic analysis provide an additional selection criterion.
19 NEUROPHARMAGEN RESULTS: DYNAMIC REPORT allowing the delivery of the most accurate approach to the patient s response beyond genetics. GENETIC RESULTS FINAL RESULTS: GENETICS + PATIENT INFO. NEUROPHARMAGEN is the first and only test to incorporate environmental factors to the genetic information in order to improve the clinical practise and the utility of the pharmacogenetics.
20 NEUROPHARMAGEN RESULTS 2.- RESULTS Information and recommendations for drugs that the analysis suggests that the patient will behave differently from the average of the population (tables in red, amber or green).
21 NEUROPHARMAGEN CLINICAL RESULTS Study conducted at 3 clinical settings in Madrid (Spain), coordinated by Hospital Clinico San Carlos (Madrid) Cross-sectional, retrospective, multi-centric study 190 in- and out-patients with full data available o o 31% inpatients 69% outpatients CGI-S 3 at baseline (92% of subjects 4) Number of non-stabilized patients (i.e CGI-S >3) almost reduced by half after 10-12wk
23 LATEST FIGURES Year Business Structure /10/ /20/ /25/35 Year Sales abroad % % % Year Contribution Margin % %
24 EXPECTATIONS. Business Area Submissions Approved EUROPA ASIA NORTH AMERICA 6 4 LATAM 21 3 MEA 60 4 Total Year License Agr
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