CURRICULUM VITAE EDUCATION POSTDOCTORAL TRAINING ACADEMIC APPOINTMENTS RESEARCH INTERESTS GRANTS

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1 CURRICULUM VITAE Rajan P. Nair, Ph.D. Associate Research Scientist Department of Dermatology Michigan 7421 Medical Science Building I, SPC East Catherine St. Ann Arbor, MI Telephone: Fax: EDUCATION N.S.S. High School, Kattampak, Kerala, India University of Kerala, Trivandrum, India, Pre-degree, (chemistry, biology, physics) University of Kerala, Trivandrum, India, B.S. (chemistry major) University of Kerala, Trivandrum, India, M.S. (chemistry) University of Kerala, Trivandrum, India, Ph.D. (organic chemistry) POSTDOCTORAL TRAINING Postdoctoral Fellow, Department of Endocrinology, Medical College of Georgia, Augusta, GA Postdoctoral Fellow, Department of Obstetrics and Gynecology, University of Michigan, Ann Arbor, MI Research Associate and Research Specialist, Howard Hughes Medical Institute, University of Michigan, Ann Arbor, MI ACADEMIC APPOINTMENTS Research Investigator and Lecturer, Department of Dermatology, University of Michigan, Ann Arbor, MI Research Assistant Professor, Department of Dermatology, University of Michigan, Ann Arbor, MI present Associate Research Scientist, Department of Dermatology, University of Michigan, Ann Arbor, MI RESEARCH INTERESTS GRANTS Identification and delineation of the genetic basis of psoriasis and psoriatic arthritis. Present and Active R01 AR (Elder, J.T., PI) 09/15/13 07/31/17 NIH/NIAMS Functional Genomics of Psoriasis

2 The major goal of this project is to identify causal variants from GWAS data in psoriasis and demonstrate their functional effects. R01 AR (Elder, J.T., PI) 09/12/12 08/31/17 NIH/NIAMS Genetics and Genomics of Psoriatic Arthritis The major goal of this project is to identify genetic and genomic determinants of psoriatic arthritis. Role: Co-Investigator R01 AR (Elder, J.T., PI) 09/1/09 08/31/15 NIH/NIAMS Linkage Analysis of Familial Psoriasis The major goal of this project is to identify the genetic determinant(s) of psoriasis Role: Co-Investigator R01 AR (Elder, J.T., PI) 08/01/09 07/31/15 NIH/NIAMS Identification of Psoriatic Arthritis Genes The major of this project is to identify the MHC determinant(s) of psoriatic arthritis Role: Co-Investigator AWARDS/HONORS Eugene M. Farber Research in Psoriasis Award, Society for Investigative Dermatology, 2007 MEMBERSHIPS AND OFFICES IN PROFESSIONAL SOCIETIES present Society for Investigative Dermatology present American Society of Human Genetics EDITORIAL POSITIONS AND PEER-REVIEW SERVICE Editorial Committee Member: Latin American Journal of Psoriasis and Psoriatic Arthritis. Reviewer for the following journals: Archives of Dermatological Research British Journal of Dermatology Disease Markers European Journal of Human Genetics Human Genetics Human Heredity Journal of Dermatological Research Journal of the European Academy of Dermatology and Venereology Journal of Investigative Dermatology Journal of Medical Genetics Molecular and Cellular Probes Pharmacogenomics Tissue Antigens Reviewer of research grants for:

3 Italian Telethon Medical Research Council, UK The Wellcome Trust, UK National Eczema Foundation NIAMS, NIH (Ad hoc reviewer) TEACHING ACTIVITIES Mentor, Undergraduate Research Opportunities Program, mentored 1-2 students every year present Mentored 1-2 postdoctoral fellows or graduate students every year. COMMITTEE, ORGANIZATIONAL, AND VOLUNTEER SERVICE present Member, Institutional Review Board, University of Michigan Medical School, reviews 1-5 human subject research protocols every week. PRESENTATIONS 1. Genome Scan Identifies Four Susceptibility Loci for Psoriasis. American Society of Human Genetics Annual Meeting, October Identification of Psoriasis Susceptibility Loci. Department of Dermatology Research Conference, University of Michigan, November Multiple Susceptibility Loci for Psoriasis. International Psoriasis Congress, Milan, Italy, September Michigan Psoriasis Research Progress. Psoriasis Gene Mapping Collaboration, Amsterdam, January Fine Mapping of the Psoriasis Locus PSORS1. American Society of Human Genetics Annual Meeting, October Homing in on a Psoriasis Gene. Department of Dermatology Research Conference, University of Michigan, January Finding a Psoriasis Gene. Department of Dermatology Research Conference, University of Michigan, September Progress in Michigan Psoriasis Genetics Research. Michigan-Kiel Psoriasis Genetics Collaboration Annual Meeting, Amsterdam, February Fine mapping of chromosome 6 psoriasis locus. Michigan-Kiel Psoriasis Genetics Collaboration Annual Meeting, Amsterdam, February Michigan Psoriasis Research Progress. Michigan-Kiel Psoriasis Genetics Collaboration Annual Meeting, Amsterdam, February Finding a Disease Gene. Dermatology Dialogue Presentation, University of Michigan, August Goals of the Michigan Psoriasis Genetics Project. Michigan-Kiel Psoriasis Genetics Collaboration Annual Meeting, Amsterdam, March Fine mapping a Psoriasis Gene and Gene Identification Strategies. Department of Dermatology Research Conference, University of Michigan, September 2004.

4 14. Gene identification in the major psoriasis susceptibility locus on chromosome 6. Michigan-Kiel Psoriasis genetics Collaboration Annual Meeting, Amsterdam, June Analysis of non-mhc psoriasis susceptibility loci PSORS2, PSORS4, PSORS5, and PSORS8. Michigan- Kiel Psoriasis genetics Collaboration Annual Meeting, Amsterdam, February Psoriasis candidate gene and MHC class III haplotype analysis. Michigan-Kiel Psoriasis Genetics Collaboration Annual Meeting, Amsterdam, February Genome Wide Association Study of psoriasis. Department of Dermatology Research Conference, University of Michigan, January Analysis of the Thai HLA-Cw1-B46 risk haplotype and fine mapping of PSORS2. Michigan-Kiel Psoriasis Genetics Collaboration Annual Meeting, Amsterdam, February Follow-up of Collaborative Association Study of Psoriasis (CASP). Dermatology Research Presentation, University of Michigan, September Replication of Association of ZNF313 Locus on Chromosome 20q13 with Psoriasis. Psoriasis Gene to Clinic Conference, London, December Progress in the Michigan Psoriasis Genetics Study. Michigan-Kiel Psoriasis Genetics Collaboration Annual Meeting, Amsterdam, February Following up on Genome Wide Association Study of psoriasis. Department of Dermatology Research Conference, University of Michigan, September Progress in the Michigan Psoriasis Genetics Study. Michigan-Kiel Psoriasis Genetics Collaboration Annual Meeting, Amsterdam, February Michigan Psoriasis Genetics Study: Recent Progress and Plans. Michigan-Kiel Psoriasis Genetics Collaboration Annual Meeting, Amsterdam, February Psoriasis Susceptibility Genes. Department of Dermatology Research Conference, University of Michigan, November First Pass Analysis of Immunochip Data. International Psoriasis and Arthritis Research Team annual meeting, Toronto, November Replication of Eighteen Psoriasis Genetic Associations in Psoriasis. Psoriasis Gene to Clinic conference in London, December Immunochip and psa GWAS Analysis Results. Progress and Plans. Michigan-Kiel Psoriasis Genetics Collaboration Annual Meeting, Amsterdam, January Psoriasis susceptibility genes. Medical Education Department, Toronto General Hospital, Toronto, ON, May Genomic dissection of psoriasis and psoriatic arthritis - extension of IPART, International Psoriasis and Arthritis Research Team annual meeting, Toronto, October Michigan Psoriasis Genetics Study: Recent Progress and Plans. Michigan-Kiel Psoriasis Genetics Collaboration Annual Meeting, Amsterdam, January Designing a genetic association study. Department of Dermatology, All India Institute of Medical Sciences, New Delhi, India, January Genetic association of psoriasis and psoriatic arthritis. Department of Dermatology Research Conference, University of Michigan, February Meta-analysis of psoriasis and psoriatic arthritis identifies three new susceptibility loci. International Investigative Dermatology meeting, Edinburgh, Scotland.

5 PATENT Nair RP, Upadhyay VK, Bannore SN, Subbarao HN, Dev S. Mixture of cis pinanol and epoxycarene. Indian Patent No. 79/B , BIBLIOGRAPHY Peer-Reviewed Publications 1. Joshua CP, Nair RP: Synthesis of amidinothioureas. Chemistry and Industry 1974: Joshua CP, Nair RP: Synthesis of biguanide. Chemistry and Industry 1974: Joshua CP, Nair RP: Interaction of dicyandiamide with thiocarbamide: formation of 2,4-diamino-6- mercapto-s-triazine and biguanide. Indian J Chem 12: , Joshua CP, Nair RP: Interaction of dicyandiamides with thioamides. Australian J Chem 27: , Joshua CP, Nair RP: Interaction of dicyandiamides with thioureas. Australian J Chem 28: , Joshua CP, Nair RP: Reaction of isothiocyanates with thiourea and amidinothioureas. Australian J Chem 29: , Joshua CP, Nair RP: Reaction of dicyandiamide with thiosemicarbazide and thiocarbohydrazide. Australian J Chem 29: , Indukumari PV, Joshua CP, Nair RP: Oxidation and eliminative cyclization of S-alkylisothioureas. Indian J Chem 20B: , Nair RP, Bannore SN, Subbarao HN, Dev S: Ligand effects in epoxidations by hydroperoxides using molybdenum catalysts: epoxidation of 3-carene. Tetrahedron 40: , Powell MM, Nair RP, Cohen JD, Bhalla VK: Gonadal receptors: upregulation in response to elevated serum gonadotropin levels. Biol Reprod 25: , Nair RP, Powell MM, Burgett AC, Bhalla VK: Ethanol-induced release of adenosine 3',5'-monophosphate into the medium by rat testis in vitro. Endocrinology 110:80-88, Bhalla VK, Nair RP, Newman ME: Alcohol-induced luteinizing hormone receptor deficiency at the testicular level. Alcoholism (NY) 7: , Nair RP, Menon KMJ: Involvement of microtubules in lipoprotein degradation and utilization for progesterone production in cultured rat luteal cells. Endocrinology, 117: , Nair RP, Menon KMJ: Evidence that dissociation, not intracellular degradation, is the major pathway for removal of receptor-bound human chorionic gonadotropin in cultured rat luteal cells. Biol Reprod, 33:60-66, Bhalla VK, Nair RP, Burgett AC, Sohal GS: Interstitial cell heterogeneity in rat testes Part I: purification of collagenase dispersed Leydig cells by unit gravity sedimentation and demonstration of binding sites for gonadotropin in light cells versus enhanced steroidogenesis in heavier cells. J Biol Chem 262: , Nair RP, Menon KMJ: Metabolism of high density lipoprotein in cultured rat luteal cells. Biochim Biophys Acta 921:25-37, 1987.

6 17. Nair RP, Menon KMJ: Differential uptake and metabolism of free and esterified cholesterol from high density lipoprotein in the rat ovary. Biochim Biophys Acta, 959: , Nair RP, Menon KMJ: Cholesterol flux between high density lipoproteins and cultured rat luteal cells. Endocrinology, 124: , Ernst LK, Nair RP, Larsen RD, Ruff MM, Lowe JB: Stable expression of blood group H determinants and GDP-L-fucose:b-D-galactoside 2-a-L-fucosyltransferase in mouse cells after transfection with human DNA. J Biol Chem, 264: , Larsen RD, Nair RP, Ruff MM, Kukowska-Latallo J, Cummings RD, Lowe JB: Isolation of a cdna encoding murine UDP-galactose: b-d-galactosyl-1,4-n-acetyl-d-glucosaminide a-1,3-galactosyltransferase: Expression cloning by gene transfer. Proc Natl Acad Sci USA, 86: , Nair RP, Larsen RD, Ajmera S, Ernst LK, Lowe JB: A cloned human DNA restriction fragment determines expression of a GDP-L-fucose:b-D-galactoside 2-a-L-fucosyltransferase in transfected cells. J Biol Chem, 264: , Larsen RD, Ernst LK, Nair RP, Lowe JB: Molecular cloning, sequence, and expression of a human GDP- L-fucose: -D-galactoside 2-a-L-fucosyltransferase cdna that can form the H blood group antigen. Proc Natl Acad Sci USA, 87: , Kukowska-Latallo J, Larsen RD, Nair RP, Lowe JB: A cloned human cdna determines expression of a mouse stage-specific embryonic antigen and the Lewis blood group a(1,3/1,4)fucosyltransferase. Genes and Development, 4: , Lowe JB, Stoolman LM, Nair RP, Larsen RD, Berhendt T, Marks RM: ELAM-1-dependent cell adhesion to vascular endothelium determined by a transfected human fucosyltransferase cdna. Cell, 63: , Lowe JB, Kukowska-Latallo J, Nair RP, Larsen RD, Marks RM, Macher BA, Kelly RJ, Ernst LK: Molecular cloning of a human fucosyltransferase gene that determines expression of the Lewis x and VIM- 2 epitopes but not ELAM-1-dependent cell adhesion. J Biol Chem, 266: , Dumas DP, Ichikawa Y, Wong C-H, Lowe JB, Nair RP: Enzymatic synthesis of sialyl Le x and derivatives based on a recombinant fucosyltransferase. Biorganic & Medicinal Chemistry Letters, 1: , Lowe JB, Stoolman LM, Nair RP, Larsen RD, Behrend TL, Marks RM: A transfected human fucosyltransferase cdna determines biosynthesis of oligosaccharide ligand(s) for endothelial-leucocyte adhesion molecule I. Biochem Soc Trans, 19: , Weston BW, Nair RP, Larsen RD, Lowe JB: Isolation of a novel human a(1,3)fucosyltransferase gene and molecular comparison to the human Lewis blood group a(1,3/1,4)fucosyltransferase gene: syntenic, homologous, non-allelic genes encoding enzymes with distinct acceptor substrate specificities. J Biol Chem, 267: , Elder JT, Hammerberg C, Cooper KD, Kojima T, Nair RP, Ellis CN, Voorhees JJ: Cyclosporin A rapidly inhibits epidermal cytokine expression in psoriasis lesions, but not in cytokine-stimulated cultured keratinocytes. J Invest Dermatol 101:761-6, Elder JT, Nair RP, Guo SW, Henseler T, Christophers E, Voorhees JJ: The genetics of psoriasis. Arch Dermatol 130: , Elder JT, Nair RP, Voorhees JJ: Epidemiology and the genetics of psoriasis. J Invest Dermatol 102:24S- 27S, Elder JT, Henseler T, Christophers E, Voorhees JJ, Nair RP: Of genes and antigens: the inheritance of psoriasis. J Invest Dermatol 103:150S-153S, 1994.

7 33. Nair RP, Guo S-W, Jenisch S, Henseler T, Lange EM, Terhune M, Westphal E, Christophers E, Voorhees JJ, Elder JT: Scanning chromosome 17 for psoriasis susceptibility: lack of evidence for a distal 17q locus. Hum Hered 45: , Nair RP, Henseler T, Jenisch S, Stuart P, Bichakjian CK, Lenk W, Westphal E, Guo SW, Christophers E, Voorhees JJ, Elder JT: Evidence for two psoriasis susceptibility loci (HLA and 17q) and two novel candidate regions (16q and 20p) by genome-wide scan. Human Mol. Genetics, 6: , Bichakjian CK, Nair RP, Wu WW, Goldberg S, Elder JT: Prenatal exclusion of lamellar ichthyosis based on identification of two new mutations in the transglutaminase1 gene. J Invest Dermatol 110: , Jenisch S, Henseler T, Nair RP, Guo SW, Westphal E, Stuart S, Kronke M, Voorhees JJ, Christophers E, Elder JT: Linkage analysis of human leucocyte antigen (HLA) markers in familial psoriasis: strong disequilibrium effects provide evidence for a major determinant in the HLA-B-C region. Am. J. Hum. Genet. 63: , Jenisch S, Westphal E, Nair RP, Stuart P, Voorhees JJ, Christophers E, Krönke M, Elder JT, Henseler T: Linkage disequilibrium analysis of familial psoriasis: identification of multiple disease-associated MHC haplotypes. Tissue Antigens 53: , Jenisch S, Koch S, Henseler T, Nair RP, Elder JT, Watts CE, Westphal E, Voorhees JJ, Christophers E, Krönke M: Corneodesmosin gene polymorphism demonstrates strong linkage disequilibrium with HLA and association with psoriasis vulgaris. Tissue Antigens 54: , Nair RP, Stuart P, Henseler T, Jenisch S, Chia NVC, Schork NJ, Kim J, Lim HW, Christophers E, Voorhees JJ, Elder JT: Fine mapping of psoriasis susceptibility locus PSORS1 to a 60 kilobase interval telomeric to HLA-C. Am J Hum Genet 66: , Stoll SW, Chia NC, Nair RP, Woods TL, Stuart P, Henseler T, Jenisch S, Christophers E, Voorhees JJ, Elder JT: S100A2 coding sequence polymorphism: characterization and lack of association with psoriasis. Clin Exp Dermatol. 26:79-83, Chia NV, Stuart P, Nair RP, Henseler T, Jenisch S, Lim HW, Christophers E, Voorhees JJ, Elder JT: Variations in the HCR (Pg8) gene are unlikely to be causal for familial psoriasis. J Invest Dermatol. 116:823-4, Nair RP, Stuart P, Ogura Y, Inohara N, Henseler T, Jenisch S, Christophers E, Voorhees JJ, Nuñez G, Elder JT: Lack of association between NOD2 3020InsC frameshift mutation and psoriasis. J Invest Dermatol 117: , Elder JT, Nair RP, Henseler T, Jenisch S, Stuart P, Chia N, Christophers E, Voorhees JJ: The genetics of psoriasis 2001: The odyssey continues. Arch Dermatol 137: , Stuart P, Malick F, Nair RP, Henseler T, Lim HW, Jenisch S, Voorhees JJ, Christophers E, Elder JT: Analysis of phenotypic variation in psoriasis as a function of age at onset and family history. Arch Dermatol Res 294: , Graham RR, Ortmann WA, Langefeld CD, Jawaheer D, Selby SA, Rodine PR, Baechler EC, Rohlf KE, Shark KB, Espe KJ, Green LE, Nair RP, Stuart PE, Elder PE, King RA, Moser KL, Gaffney PM, Bugawan TL, Erlich HA, Rich SS, Gregersen PK, Behrens TW: Visualizing Human Leukocyte Antigen Class II Risk Haplotypes in Human Systemic Lupus Erythematosus. Am J Hum Genet 71: , Guo SW, Jenisch S, Stuart P, Lange EM, Kukuruga D, Nair R, Henseler T, Voorhees J, Christophers E, Elder JT: Combined segregation and linkage analysis of HLA markers in familial psoriasis. Eur J Hum Genet 10:327-33, International Psoriasis Genetics Consortium (Allen M, Barker JNWN, Bowcock AM, Burden AD, Chia N, Capon F, Christophers E, Daly MJ, Elder JT, Helms C, Henseler T, Jenisch S, Menter A, Mistry R, Nair

8 RP, Stuart PE, Tillman D, Trembath RC, Veal C, Voorhees JJ): The international psoriasis genetics study: assessing linkage to 14 candidate susceptibility loci in a 942 affected-sib-pair cohort. Am J Hum Genet 73: , Sagoo GS, Tazi-Ahnini R, Barker JW, Elder JT, Nair RP, Samuelsson L, Traupe H, Trembath RC, Robinson DA, Iles MM: Meta-Analysis of Genome-Wide Studies of Psoriasis Susceptibility Reveals Linkage to Chromosomes 6p21 and 4q28-q31 in Caucasian and Chinese Hans Population. J Invest Dermatol. 122: , Elder JT, Nair RP, Weichenthal M, Stuart P, Voorhees JJ, Christophers E, Jenisch S: The MHC genes in psoriasis. Current Genomics 6:39-43, The Cluster 17 Collaboration (Abecasis G, Allen M, Barker JNWN, Burden D, Capon F, Christophers E, Elder JT, Fischer J, Giardina E, Gudjonsson JE, Hüffmeier U, Jenisch S, Karason A, Kere J, Nair RP, Novelli G, Prud homme J-F, Qin ZS, Samuelsson L, Sanchez F, Saarialho-Kere U, Ståhle M, Stuart P, Tilman D, Traupe H, Trembath R, Valdimarsson H, Veal C, Voorhees JJ, Weichenthal M): Fine mapping of the psoriasis susceptibility gene PSORS1: A reassessment of risk associated with a putative risk haplotype lacking HLA-Cw6). J Invest Dermatol 124: , Nistor I, Nair RP, Stuart PE, Hiremagalore R, Thompson RA, Jenisch S, Weichenthal M, Abecasis GR, Qin S, Christophers E, Lim HW, Voorhees JJ, and Elder JT: Protein tyrosine phosphatase gene PTPN22 polymorphisms in psoriasis: lack of evidence for association. J Invest Dermatol 125: , Stuart PE, Nair RP, Abecasis GR, Nistor I, Hiremagalore R, Chia NV, Qin ZS, Thompson RA, Jenisch S, Weichenthal M, Janiga J, Lim HW, Christophers E, Voorhees JJ, and Elder JT: Analysis of RUNX1 binding site and Raptor polymorphisms in psoriasis: no evidence for association despite adequate power and evidence for linkage. J Med Genet 43:12-17, Jenisch S, Hampe J, Elder JT, Nair R, Stuart P, Voorhees JJ, Schreiber S, Kabelitz D, Christophers E, Weichenthal M: CARD15 mutations in patients with plaque-type psoriasis and psoriatic arthritis: lack of association. Arch Dermatol Res 297: , Nair RP, Stuart P, Nistor I, Hiremagalore R, Chia NVC, Jenisch S, Weichenthal M, Abecasis G, Lim HW, Christophers E, Voorhees JJ, Elder JT: Sequence and haplotype analysis supports HLA-C as the psoriasis susceptibility gene. Am J Hum Genet 78: , Poynter JN, Elder JT, Fullen DR, Nair RP, Soengas MS, Johnson TM, Redman B, Thomas NE, Gruber SB: BRAF and NRAS mutations in melanoma and melanocytic nevi. Melanoma Res 16:267-73, Fullen DR, Poynter JN, Lowe L, Su LD, Elder JT, Nair RP, Johnson TM, Gruber SB: BRAF and NRAS mutations in spitzoid melanocytic lesions. Mod Pathol 19: , Verhaegen M, Bauer JA, Martin de la Vega C, Wang G, Wolter KG, Brenner JC, Nikolovska-Coleska Z, Bengtson A, Nair R, Elder JT, Van Brocklin M, Carey TE, Bradford CR, Wang S, Soengas MS: A novel BH3 mimetic reveals a mitogen-activated protein kinase-dependent mechanism of melanoma cell death controlled by p53 and reactive oxygen species. Cancer Res. 66: , Kia KF, Nair RP, Ike RW, Hiremagalore R, Elder JT, Ellis CN: Prevalence of antigliadin antibodies in patients with psoriasis is not elevated compared with controls. Am J Clin Dermatol 8:301-5, Weichenthal M, Ruether A, Schreiber S, Nair R, Voorhees JJ, Schwarz T, Kabelitz D, Christophers E, Elder JT, Jenisch S: Filaggrin R501X and 2282del4 mutations are not associated with chronic plaque-type psoriasis in a German cohort. J Invest Dermatol 127:1535-7, Nair RP, Ruether A, Stuart PE, Jenisch S, Tejasvi T, Hiremagalore R, Schreiber S, Kabelitz D, Lim HW, Voorhees JJ, Christophers E, Elder JT, Weichenthal M: Polymorphisms of the IL12B and IL23R Genes Are Associated with Psoriasis. J Invest Dermatol 128: , 2008.

9 61. Gudjonsson JE, Aphale A, Grachtchouk M, Ding J, Nair RP, Wang T, Voorhees JJ, Dlugosz AA, Elder JT: Lack of Evidence for Activation of the Hedgehog Pathway in Psoriasis. J Invest Dermatol 129:635-40, Nair RP, Duffin KC, Helms C, Ding J, Stuart PE, Goldgar D, Gudjonsson JE, Li Y, Tejasvi T, Feng BJ, Ruether A, Schreiber S, Weichenthal W, Gladman D, Rahman P, Schrodi SJ, Prahalad S, Guthery SL, Fischer J, Liao W, Kwok P, Menter A, Lathrop GM, Wise C, Begovich AB, Voorhees JJ, Elder JT, Krueger GG, Bowcock AM, Abecasis GR, et al.: Genome-wide Scan Reveals Association of Psoriasis with IL-23 and NF-κB Pathways. Nat Genet 41: , de Cid R, Riveira-Munoz E, Zeeuwen PL, Robarge J, Liao W, Dannhauser EN, Giardina E, Stuart PE, Nair R, Helms C, Escaramís G, Ballana E, Martín-Ezquerra G, den Heijer M, Kamsteeg M, Joosten I, Eichler EE, Lázaro C, Pujol RM, Armengol L, Abecasis G, Elder JT, Novelli G, Armour JA, Kwok PY, Bowcock A, Schalkwijk J, Estivill X: Deletion of the late cornified envelope LCE3B and LCE3C genes as a susceptibility factor for psoriasis. Nat Genet 41:211-5, Nair RP, Ding J, Duffin K., Helms C, Voorhees JJ, Krueger GG, Bowcock AM, Abecasis GR, and Elder JT: Psoriasis bench to bedside: genetics meets immunology. Arch Dermatol 145:462-4, Feng BJ, Sun LD, Soltani-Arabshahi R, Bowcock AM, Nair RP, Stuart P, Elder JT, Schrodi SJ, Begovich AB, Abecasis GR, Zhang XJ, Callis-Duffin KP, Krueger GG, Goldgar DE: Multiple Loci within the major histocompatibility complex confer risk of psoriasis. PLoS Genet 5:e , Gudjonsson JE, Ding J, Li X, Nair RP, Tejasvi T, Qin ZS, Ghosh D, Aphale A, Gumucio DL, Voorhees JJ, Abecasis GR, Elder JT: Global Gene Expression Analysis Reveals Evidence for Decreased Lipid Biosynthesis and Increased Innate Immunity in Uninvolved Psoriatic Skin. J Invest Dermatol 129: , Elder JT, Bruce AT, Gudjonsson JE, Johnston A, Stuart PE, Tejasvi T, Voorhees JJ, Abecasis GR, Nair RP: Molecular Dissection of Psoriasis: Integrating Genetics and Biology. J Invest Dermatol 130: , Nair RP, Stuart PE, Kullavanijaya P, Kullavanijaya P, Tejasvi T, Voorhees JJ, Elder JT: Genetic evidence for involvement of the IL23 pathway in Thai psoriatics. Arch Dermatol Res 302: , Gudjonsson JE, Ding J, Johnston A, Tejasvi T, Guzman AM, Nair RP, Voorhees JJ, Abecasis GR, Elder JT: Assessment of the Psoriatic Transcriptome in a Large Sample: Additional Regulated Genes and Comparisons with In Vitro Models. J Invest Dermatol 130: , Gudjonsson JE, Johnston A, Stoll SW, Riblett MB, Xing X, Kochkodan JJ, Ding J, Nair RP, Aphale A, Voorhees JJ, Elder JT: Evidence for Altered Wnt Signaling in Psoriatic Skin. J Invest Dermatol 130: , Stuart PE, Nair RP, Hiremagalore R, Kullavanijaya P, Kullavanijaya P, Tejasvi T, Lim HW, Voorhees JJ, Elder JT: Comparison of MHC class I risk haplotypes in Thai and Caucasian psoriatics shows locus heterogeneity at PSORS1. Tissue Antigens 76: , Ellinghaus E, Ellinghaus D, Stuart PE, Nair RP, Debrus S, Raelson JV, Ding D, Li Y, Tejasvi T, Gudjonsson J, Stephan Weidinger, Eberlein B, Kunz M, Rahman P, Gladman D, Gieger C, Wichmann HE, Karlsen TH, Kabelitz D, Abecasis GR, Elder JT, Schreiber S, Weichenthal W, and Franke A:Genome-wide association study identifies a psoriasis susceptibility locus at TRAF3IP2. Nat Genet 42:991-5, Stuart PE *, Nair RP *, Ellinghaus E, Ding J, Tejasvi T, Gudjonsson JE, Li Y, Weidinger S, Eberlein B, Gieger C, Wichmann HE, Kunz M, Ike R, Krueger GG, Bowcock AM, Mroweitz U, Lim HW, Voorhees JJ, Abecasis GR, Weichental M, Franke A, Rahman P, Gladman D, and Elder JT: Genome-wide association analyses identifies three psoriasis susceptibility loci. Nat Genet 42:1000-4, * co-first authors.

10 74. Sun LD, Wang Cheng Z-X, H, Zhang AP, Wang P-G, Xu J-H, Zhu Q-X, Zhou H-S, Buchert E, Zhang F-R, Pu X-M, Yang X-Q, Zhang J-Z, Xu A-E, Wu R-N, L-M Xu, Peng L, Helms CA, Ren Y-Q, Zhang C, Zhang S-M, Nair RP, Wang H-Y, Lin G-S, Stuart PE, Fan Chen X, G, Tejasvi T, Li P, Zhu J, Li Z-M, Ge H-M, Weichenthal M, Ye W-Z, Zhang C, Shen S-K, Yang B-Q, Sun Y-Y, Li S-S, Lin Y, Jiang J-H, Li C-T, Chen R-X, Cheng J, Jiang X, Zhang P, Song W-M, Tang J, Zhang H-Q, Sun L, Cui J, Zhang L-J, Tang B, Huang F, Qin Q, Pei X-P, Zhou A-M, Shao L-M, Liu J-L, Zhang F-Y, Du W-D, Franke A, Bowcock AM, Elder JT, Liu J-J, Yang S, Zhang X-J: Follow-up study identifies six novel psoriasis susceptibility loci in the Chinese Han population. Nat Genet 42:1005-9, Ding J, Gudjonsson JE, Liang L, Stuart PE, Li Y, Chen W, Weichenthal M, Ellinghaus E, Franke A, Cookson W, Nair RP, Elder JT, Abecasis GR: Gene expression in skin and lymphoblastoid cells: Refined statistical method reveals extensive overlap in cis-eqtl signals. Am J Hum Genet 87:779-89, Riveira-Munoz E, He SM, Escaramís G, Stuart PE, Hüffmeier U, Lee C, Kirby B, Oka A, Giardina E, Liao W, Bergboer J, Kainu K, de Cid R, Munkhbat B, Zeeuwen PL, Armour JA, Poon A, Mabuchi T, Ozawa A, Zawirska A, Burden AD, Barker JN, Capon F, Traupe H, Sun LD, Cui Y, Yin XY, Chen G, Lim HW, Nair RP, Voorhees JJ, Tejasvi T, Pujol R, Munkhtuvshin N, Fischer J, Kere J, Schalkwijk J, Bowcock A, Kwok PY, Novelli G, Inoko H, Ryan AW, Trembath RC, Reis A, Zhang XJ, Elder JT, Estivill X: Meta-Analysis Confirms the LCE3C_LCE3B Deletion as a Risk Factor for Psoriasis in Several Ethnic Groups and Finds Interaction with HLA-Cw6. J Invest Dermatol 131:1105-9, Swindell WR, Johnston A, Carbajal S, Han G, Wohn C, Lu J, Xing X, Nair RP, Voorhees JJ, Elder JT, Wang XJ, Sano S, Prens EP, Digiovanni J, Pittelkow MR, Ward NL, Gudjonsson JE: Genome-wide expression profiling of five mouse models identifies similarities and differences with human psoriasis. PLoS One 6:e18266, Tejasvi T, Stuart PE, Chandran V, Voorhees JJ, Gladman DD, Rahman P, Elder JT, Nair RP: TNFAIP3 gene polymorphisms are associated with response to TNF blockade in psoriasis. J Invest Dermatol 132: , Ellinghaus E, Stuart PE, Ellinghaus D, Nair RP, Debrus S, Raelson JV, Belouchi M, Tejasvi T, Li Y, Tsoi LC, Onken AT, Esko T, Metspalu A, Rahman P, Gladman DD, Bowcock AM, Helms C, Krueger GG, Koks S, Kingo K, Gieger C, Wichmann HE, Mrowietz U, Weidinger S, Schreiber S, Abecasis GR, Elder JT, Weichenthal M, Franke A: Genome-Wide Meta-Analysis of Psoriatic Arthritis Identifies Susceptibility Locus at REL. J Invest Dermatol 132: , Swindell WR, Xing X, Stuart PE, Chen CS, Aphale A, Nair RP, Voorhees JJ, Elder JT, Johnston A, Gudjonsson JE: Heterogeneity of inflammatory and cytokine networks in chronic plaque psoriasis. PLoS One 7:e34594, Ellinghaus D, Ellinghaus E, Nair RP, Stuart PE, Esko T, Metspalu A, Debrus S, Raelson JV, Tejasvi T, Belouchi M, West SL, Barker JN, Kõks S, Kingo K, Balschun T, Palmieri O, Annese V, Gieger C, Wichmann HE, Kabesch M, Trembath RC, Mathew CG, Abecasis GR, Weidinger S, Nikolaus S, Schreiber S, Elder JT, Weichenthal M, Nothnagel M, Franke A: Combined analysis of genome-wide association studies for Crohn disease and psoriasis identifies seven shared susceptibility loci. Am J Hum Genet 90:636-47, Jordan CT, Cao L, Roberson ED, Duan S, Helms CA, Nair RP, Duffin KC, Stuart PE, Goldgar D, Hayashi G, Olfson EH, Feng BJ, Pullinger CR, Kane JP, Wise CA, Goldbach-Mansky R, Lowes MA, Peddle L, Chandran V, Liao W, Rahman P, Krueger GG, Gladman D, Elder JT, Menter A, Bowcock AM: Rare and Common Variants in CARD14, Encoding an Epidermal Regulator of NF-kappaB, in Psoriasis. Am J Hum Genet 90: , Stuart PE *, Hüffmeier U *, Nair RP *, Palla R, Tejasvi T, Schalkwijk J, Elder JT, Reis A, Armour JAL: Association of β-defensin copy number and psoriasis in three cohorts of European origin. J Invest Dermatol 132: , 2012.

11 * co-first authors. 84. Tsoi LC, West SL, Knight J, Ellinghaus E, Stuart PE, Capon F, Ding J, Li Y, Kang HM...(36 others)... Rahman P, Gladman DD, Griffiths CEM, Reis A, Kere J, Nair RP, Franke F, Barker JNWN, R Abecasis GR, Elder JT, Trembath RC: Identification of 15 new psoriasis susceptibility loci highlights the role of innate immunity. Nature Genetics 44:1341-8, Johnston A, Xing X, Swindell WR, Kochkodan J, Riblett M, Nair RP, Stuart PE, Ding J, Voorhees JJ, Elder JT, Gudjonsson JE: Susceptibility-associated genetic variation at IL12B enhances Th1 polarization in psoriasis. Hum Mol Genet 22: , Shaiq PA, Stuart PE, Latif A, Schmotzer C, Kazmi AH, Khan MS, Azam M, Tejasvi T, Voorhees JJ, Raja GK, Elder JT, Qamar R, Nair RP: Genetic Associations of Psoriasis in a Pakistani Population. Br J Dermatol 169: , Li B, Tsoi LC, Swindell WR, Gudjonsson JE, Tejasvi T, Johnston A, Ding J, Stuart PE, Xing X, Kochkodan JJ, Voorhees JJ, Kang HM, Nair RP, Abecasis GR, Elder JT: Transcriptome Analysis of Psoriasis in a Large Case-Control Sample: RNA-Seq Provides Insights into Disease Mechanisms. J Invest Dermatol 134: , Okada Y, Han B, Tsoi LC, Stuart PE, Ellinghaus E, Tejasvi T, Chandran V, Pellett F, Pollock R, Bowcock AM, Krueger GG, Weichenthal M, Voorhees JJ, Rahman P, Gregersen PK, Franke A, Nair RP, Abecasis GR, Gladman DD, Elder JT, de Bakker PI, Raychaudhuri S: Fine mapping major histocompatibility complex associations in psoriasis and its clinical subtypes. Am J Hum Genet 95:162-72, Das S, Stuart PE, Ding J, Tejasvi T, Li Y, Tsoi LC, Chandran V, Fischer J, Helms C, Duffin KC, Voorhees JJ, Bowcock AM, Krueger GG, Lathrop GM, Nair RP, Rahman P, Abecasis GR, Gladman D, Elder JT: Fine mapping of eight psoriasis susceptibility loci. Eur J Hum Genet Sep 3. doi: /ejhg [Epub ahead of print] Non-Peer-Reviewed Publications 1. Elder JT, Nair RP, Voorhees JJ. Epidemiology and the genetics of psoriasis. J Invest Dermatol 102:24S- 27S, (Review article) 2. Elder JT, Henseler T, Christophers E, Voorhees JJ, Nair RP. Of genes and antigens: the inheritance of psoriasis. J Invest Dermatol 103:150S-153S, (Review article) Book Chapters 1. Bhalla VK, Powell MM, Rojas FJ, Nair RP. Gonadotropin binding model: comparison of the binding characteristics of camp to protein kinase holoenzyme and gonadotropin to particulate receptors in rat testis. In: Function correlates of hormone receptors in reproduction, Mahesh VB, Muldoon TG (Ed), Elsevier North-Holland, p. 419, Nair RP, Menon KMJ Role of microtubules in lipoprotein transport in cultured rat luteal cells In: Lipoprotein and cholesterol metabolism in steroidogenic tissues. Strauss JF, Menon KMJ (Ed), George F Stickley Press, p 197, Jenisch S, Nair RP, Henseler T, Elder JT, Marxen B, Kronke M, Westphal W: Association of Type I psoriasis with the Cw*0802-DRB1*0102-DQB1*0501 haplotype in North American multiplex families. In: 12th International Histocompatibility Workshop and Conference Proceedings: Genetic diversity of HLA: functional and medical implication. Charron, D(Ed), Serves: EDK, p , Abstracts

12 1. Nair RP, Henseler T, Brenner KF, Voorhees JJ, Christophers E, Terhune M, Griffiths CEM, Elder JT: PCR analysis of 73-alanine of HLA-C as a genetic marker for psoriasis. J Invest Dermatol 98:627A, Henseler T, Koch F, Westphal E, Nair RP, Voorhees JJ, Elder JT, Christophers E: Presence of HLA- DR7 in the type I psoriasis. J Invest Dermatol 98:607A, Nair RP, Henseler T, Lunetta K, Guo SW, Terhune M, Westphal E, Christophers E, Voorhees JJ, Elder JT: Exclusion of tight linkage between familial psoriasis and HLA genes under a single gene, autosomal dominant model. J Invest Dermatol 100:539A, Henseler T, Westphal E, Jenisch S, Nair RP, Zavazava N, Elder JT, Voorhees JJ, Christophers E: Mechanism of linkage disequilibrium between Cw6 and DR7 in type 1 psoriasis: Examples of inheritance in trans. J Invest Dermatol 100:542A, Nair RP, Kokx S, Henseler T, Jenisch S, Westphal E, Terhune M, Christophers E, Voorhees JJ, Elder JT: DNA-based typing of HLA-Cw6, a human leukocyte antigen with increased frequency in type 1 psoriasis. J Invest Dermatol 102:624A, Nair RP, Jenisch S, Guo S-W, Henseler T, Kokx S, Terhune M, Woodbury M, Westphal E, Christophers E, Voorhees JJ, Elder JT: Evidence for psoriasis susceptibility gene(s) on human chromosome 6p. J Invest Dermatol 104:598A, Henseler T, Elder JT, Nair R, Jenisch S, Lenk W, Westphal E, Voorhees JJ, Christophers E: Psoriasis and HLA-Cw7 in a Caucasian family: Role of alanine 73. J Invest Dermatol 104:598A, Jenisch S, Henseler T, Westphal E, Elder JT, Nair RP, Voorhees JJ, hristophers, ller-ruchholtz W: HLA-DQ9 (DQB1*0303) increases susceptibility to type 1 psoriasis in multiplex families, but only in the presence of HLA-Cw6. J Invest Dermatol 104:629A, Nair RP, Henseler T, Jenisch S, Stuart P, Rasmussen B, Bichakjian C, Guo SW, Westphal E, Christophers E, Voorhees JJ, Elder JT: A recombinant-based, genome-wide scan for psoriasis genes: The hunt continues. J Invest Dermatol 106:905A, Henseler T, Westphal E, Jenisch S, Nair RP, Zavazava N, Elder JT, Voorhees JJ, Christophers E: Mechanism of linkage disequilibrium between Cw6 and DR7 in type 1 psoriasis: Examples of inheritance in trans. J Invest Dermatol 100:542A, Nair RP, Kokx S, Henseler T, Jenisch S, Westphal E, Terhune M, Christophers E, Voorhees JJ, Elder JT: DNA-based typing of HLA-Cw6, a human leukocyte antigen with increased frequency in type 1 psoriasis. J Invest Dermatol 102:624A, Nair RP, Jenisch S, Guo S-W, Henseler T, Kokx S, Terhune M, Woodbury M, Westphal E, Christophers E, Voorhees JJ, Elder JT: Evidence for psoriasis susceptibility gene(s) on human chromosome 6p. J Invest Dermatol 104:598A, Henseler T, Elder JT, Nair R, Jenisch S, Lenk W, Westphal E, Voorhees JJ, Christophers E: Psoriasis and HLA-Cw7 in a Caucasian family: Role of alanine 73. J Invest Dermatol 104:598A, Jenisch S, Henseler T, Westphal E, Elder JT, Nair RP, oorhees JJ, hristophers, ller-ruchholtz W: HLA-DQ9 (DQB1*0303) increases susceptibility to type 1 psoriasis in multiplex families, but only in the presence of HLA-Cw6. J Invest Dermatol 104:629A, Nair RP, Henseler T, Jenisch S, Stuart P, Rasmussen B, Bichakjian C, Guo SW, Westphal E, Christophers E, Voorhees JJ, Elder JT: A recombinant-based, genome-wide scan for psoriasis genes: The hunt continues. J Invest Dermatol 106:905A, 1996.

13 16. Bichakjian CK, Wu WW, Elder JT, Nair RP: Two new mutations in the transglutaminase 1 gene in a lamellar ichthyosis kindred. J Invest Dermatol Henseler T, Lenk W, Jenisch S, Westphal E, Nair RP, Elder JT, Voorhees JJ, Christophers E: HLA class I haplotypes in multiplex families with type I psoriasis. J Invest Dermatol 106:935A, Elder JT, Jenisch S, Westphal, Henseler T, Nair RP, Guo S-W, Stuart P, Lenk W, Bichakjian C, Voorhees JJ, Christophers E: Familial psoriasis is linked to HLA - B and -C. J Invest Dermatol 108:561A, Bichakjian CK, Nair RP, Elder JT: Successful antenatal diagnosis of lamellar ichthyosis. J Invest Dermatol 108:599A, Nair RP, Henseler T, Jenisch S, Stuart P, Bichakjian C, Lenk W, Guo S-W, Westphal E, Malvitz E, Kim H, Christophers E, Voorhees JJ, Elder JT: Candidate susceptibility loci for familial psoriasis. J Invest Dermatol 108:645A, Nair RP, Henseler T, Jenisch S, Stuart P, Bichakjian CK, Lenk W, Westphal E, Malvitz, Christophers E, Voorhees JJ, Elder JT: Genome scan identifies four susceptibility loci for psoriasis. Am J Hum Genet 61:A42, Elder JT, Jenisch S, Westphal E, Henseler T, Nair RP, Stuart P, Guo SW, Voorhees JJ, Christophers E: Strong linkage disequilibrium localizes psoriasis susceptibility to within 0.4 Mb of HLA-C. Am J Hum Genet 61:A274, Nair RP, Henseler T, Jenisch S, Stuart P, Chia N, Westphal E, Malvitz E, Christophers E, Voorhees JJ, Elder JT: Mapping of psoriasis susceptibility locus to a 330 KB region of centromeric HLA class I (6p21.3) by linkage disequilibrium analysis. J Invest Dermatol 110: 615A, Jenisch S, Elder JT, Westphal E, Nair RP, Christophers E, Krönke M, Henseler T: Localization of a psoriasis vulgaris susceptibility allele on specific ancestral HLA-haplotypes. J Invest Dermatol 110: 619A, Stoll SW, Sciabica M, Wiesen J, Werb Z, Elder JT: Induction of HB-EGF mrna is intact in skin organ cultures of EGFR knockout mice. J Invest Dermatol 110: 625A, Nair RP, Stuart P, Henseler T, Jenisch S, Chia N, Westphal E, Arndt J, Epperson J, Christophers E, Voorhees JJ, Elder JT: Linkage disequilibrium mapping of psoriasis susceptibility locus PSORSI on chromosome 6. J Invest Dermatol 112: 640A, Chia NVC, Elder JT, Nair RP: Use of a new mutation detection technique to identify genetic mutation in a lamellar ichthyosis family. J Invest Dermatol 112: 593A, Nair RP, Chia NVC, Jenisch S, Stuart P, Epperson J, Henseler T, Westphal E, Arndt JL, Christophers E, Voorhees JJ, Elder JT: Investigation of TCF19 as a candidate gene for psoriasis susceptibility. Am J Human Genet 65:A463, Nair RP, Chia NVC, Stuart PE, Henseler T, Jenisch S, Westphal E, Arndt JL, Epperson J, Christophers E, Voorhees J, Elder J: Investigation of OTF3 and TCF19 as candidate genes for psoriasis susceptibility. J Invest Dermatol 114: 452A, Chia NVC, Stoll SW, Woods TL, Nair RP, Stuart P, Elder JT: S100A2 sequence polymorphism is not associated with psoriasis. J Invest Dermatol 114: 713A, Nair RP, Stuart P, Henseler T, Jenisch S, Chia NVC, Westphal E, Schork NJ, Kim J, Lim HW, Christophers E, Voorhees JJ, Elder JT : Phenotypic characterization of the EH57.1 disease allele at psoriasis susceptibility locus PSORS1. Am J Hum Genet 67 (4) Suppl 2: 47A, Nair R, Chia N, Shahabi L, Stuart P, Henseler S, Christophers E, Voorhees H, Elder J: Sequence variation in a retrovirus-like expressed sequence tag in the PSORS1 critical region of the MHC: Lack of evidence for a causative psoriasis gene. J Invest Dermatol 117: 513A, 2001.

14 31. Chia N, Stuart P, Nair RP, Henseler T, Lim H, Jenisch S, Christophers E, Voorhees J, Elder J: Analysis of HCR gene polymorphism in familial psoriasis: Evidence against a causal role. J Invest Dermatol 117: 514A, Elder J, Malick F, Stuart P, Lim H, Nair RP, Jenisch, Christophers E, Voorhees, J: Differential relationship of disease severity to age of onset in familial vs. sporadic psoriasis. J Invest Dermatol 117: 514A, Nair RP, Stuart P, Chia N, Epperson J, Nistor I, Henseler T, Jenisch S, Christophers E, Voorhees J, Elder J: Analysis of the deletion of a tandem repeat sequence in human STG gene in psoriasis. J Invest Dermatol 117: 262A, Elder JT, Barker JN, Burden D, Chia N, Christophers E, Daly M, Helms C, Henseler T, Jenisch S, Menter A, Mistry R, Nair RP, Stuart P, Tillman D, Veal C, Voorhees JJ, Trembath R, Bowcock AM: Linkage of psoriasis to the MHC and evidence for additional loci in the large cohort (International Psoriasis Genetics Consortium). J Invest Dermatol 117: 266A, Elder JT, Poynter J, Ge C, Johnson J, Nair RP, Redman B, Soengas M, Gruber S: BRAF exon 15 mutations in melanoma: presence in primary melanomas and evidence for constitutive ERK activation in the absence of mutation. J Invest Dermatol 121: 0166A, Nair RP, Stuart P, Epperson, J, Nistor I, Dubal N, Weichenthal M, Jenisch S, Christophers E, Voorhees JJ, Elder JT: Genomic Sequence analysis of PSORSI. J Invest Dermatol 121: 0611A, Eymess A, Weichenthal M, Wedler M, Nair RP, Elder JT, Voorhees JJ, Christophers E, Kabelitz D, Jenisch S: Analysis of the MIC-B polymorphism and its association with psoriasis. Genes and Immunity 4 (Suppl): S6, Nair RP, Stuart P, Nistor I, Kullavanijaya P, Weichenthal M, Jenisch S, Christophers E, Voorhees JJ, Elder JT: Sequence analysis of PSORS1 candidate genes: Only HLA-C and CDSN encode proteins unique to risk haplotypes. J. Invest Dermatol 122: 495A, Hiremagalore R, Nair RP, Stuart P, Nistor I, Thompson R, Jenisch S, Weichenthal M, Christophers E, Lim H, Voorhees J, Elder JT: Lack of association of VEGF 405G/C polymorphism with psoriasis. J Invest Dermatol 124: A79, Nair RP, Stuart P, Hiremagalore R, Nistor I, Thompson R, Jenisch S, Weichenthal M, Christohers E, Abecasis G, Qin Z, Lim H, Voorhees J, Elder JT: Lack of association of psoriasis with RUNX1 and RAPTOR polymorphisms in PSORS2 locus on chromosome 17. J Invest Dermatol 124: A79, Nistor I, Nair RP, Stuart P, Hiremagalore R, Thompson R, Jenisch S, Weichenthal M, Christophers E, Lim H, Voorhees J, Elder JT: Protein tyrosine phosphatase gene PTPN22 polymorphism is not associated with psoriasis. J Invest Dermatol 124: A80, Gudjonsson JE, Ding J, Nair RP, Abecasis G, Voorhees JJ, Elder JT: Global gene expression analysis of psoriasis reveals differences between normal and uninvolved skin. J Invest Dermatology 126 (suppl): 14, Hiremagalore R, Inohara N, Nair RP, Stuart PE, Jenisch S, Weichenthal M, Lim HW, Christophers E, Voorhees JJ, Nunez G, Elder JT: Genetic association analysis of NOD27 as a candidate gene psoriasis susceptibility. J Invest Dermatology 126 (suppl): 80, Nair RP, Stuart PE, Nistor I, Hiremagalore R, Jenisch S, Weichenthal M, Abecasis GR, Lim HW, Christophers E, Voorhees JJ, Elder JT: Genomic sequencing and haplotype analysis identify HLA-C as the PSORS1 gene. J Invest Dermatolgy 126 (suppl): 84, Tejasvi T, Nair RP, Stuart P, oorhees JJ, lder JT: ffectiveness of psoriasis treatments: a patients perspective. J Invest Dermatology 127 (suppl): 357, 2007

15 46. Nair RP, Stuart PE, Qin AZ, Abecasis GR, Jenisch S, Weichenthal M, Lim HW, Christophers E, Voorhees JJ, Elder JT: Fine mapping of psoriasis susceptibility locus PSORS2 on chromosome17q. J Invest Dermatology 126 (suppl): 533, Gudjonsson J, Tejasvi T, Aphale A, Stoll S, Nair R, Voorhees, J, Elder JT: Differences in the expression of HLA class I molecules in uninvolved and involved psoriatic skin. J Invest Dermatol 127 suppl 2, S72 (2007) 48. Weichenthal M, Nair RP, Ruether A, Stuart PE, Schreiber S, Christophers E, Voorhees J, Elder JT, Jenisch S: Polymorphisms of the IL12B and IL23R genes are associated with psoriasis. J Invest Dermatol 127 suppl 2, S86 (2007) 49. Tejasvi T, Stuart PE, Nair RP, Voorhees JJ, Elder JT: Initial pharmacogenomic assessment of TNF-alpha and TRAF1 ploymorphisms in psoriasis: response to TNF blockers and other systemic therapies. J Invest Dermatol 128, suppl 1, A442, Nair RP, Stuart PE, Kullavanijaya P, Kullavanijaya P, Tejasvi T, Voorhees JJ, Elder JT: Genetic evidence for involvement of the IL23 pathway in Thai psoriatics. J Invest Dermatol 128, suppl 1, A678, Elder JT, Callis Duffin K, Helms C, Stuart PE, Ding J, Goldgar D, Tejasvi T, Gudjonsson JE, Liao W, Menter A, Voorhees JJ, Abecasis GR, Nair RP, Bowcock AM, Krueger GG: Genome-wide association scan reveals novel psoriasis susceptibility loci. J Invest Dermatol 128, suppl 1, A747, Gudjonsson JE, Ding J, Nair RP, Stuart PE, Aphale A, Tejasvi T, Voorhees JJ, Abecasis GR, Elder JT: Global gene expression analysis reveals evidence for abnormal lipid biosynthesis in uninvolved psoriatic skin. J Invest Dermatol 128, suppl 1, A768, Tejasvi T, Stuart PE, Nair RP, Voorhees JJ, Elder JT: Polymorphisms in TNFAIP3 as a predictor of response to TNF blockage in psoriasis. J Invest Dermatol 129, suppl 1, A327, Nair RP, Stuart PE, Hiremagalore R, Kullavanijaya P, Tejasvi T, Voorhees JJ, Elder JT: Analysis of the HLA-Cw1-B46 psoriasis risk haplotype reveals allelic herogeneity with HLA-Cw6. J Invest Dermatol 129, suppl 1, A489, Feng B, soltani-arabshi R, Bowcock AM, Nair RP, Elder JT, Schrodi SJ, Begovich AB, Abecasis GR, Callis-Duffin KP, Goldgar DE, Krueger GG: Multiple independent loci within the major histocompatibility complex confer risk of psoriasis. J Invest Dermatol 129, suppl 1, A510, Nair RP, Stuart PE, Voorhees JJ, Elder JT: Haplotype analysis implicates MICA*002 in susceptibility to psoriatic arthritis. J Invest Dermatol 129, suppl 1, A532, Gudjonsson JE, Ding J, Nair RP, Liang L. Voorhees JJ, Abecasis GR, Elder JT: A genome-wide association study of gene expression in skin and psoriatic lesions. J Invest Dermatol 129, suppl 1, A535, Gudjonsson JE, Ding J, Johnston A, Guzman A, Nair RP, Voorhees JJ, Abecasis GR, Elder JT: Comprehensive analysis of the psoriatic transcriptome and comparison with previous studies and cytokine models. J Invest Dermatol 129, S49-S49, Schrodi SJ, Li YH, Chang M, Garcia VE, Duffin KC, Nair RP, Bowcock AM, Elder JT, Krueger GG, Rowland CM: Trait Prediction Using Multi-Locus Information: Psoriasis as a Model for Complex Disease Prognostics. Genetics Epidemiology 33, , Stuart PE, Nair RP, Buchert E, Ding J, Tejasvi T, Gudjonsson JE, Li Y, Abecasis GR, Krueger GG, Bowcock AM, Voorhees JJ, Weichental M, Franke A, Rahman P, Gladman DD, Elder JT: genome-wide association scan identifies twelve susceptibility loci for psoriasis and/or psoriatic arthritis. Clin Exp Rheumatol 28: , Gudjonsson JE, Xing X, Nair RP, Voorhees JJ, Johnston A, Elder JT: The psoriasis associated IL12B risk haplotype influences IL-12 and IL-23 expression and secretion. J Invest Dermatol 13: S20-S20, 2010.

16 62. Tejasvi T, Stuart PE, Nair RP, Voorhees JJ, Elder JT: Interaction between psoriasis susceptibility loci ERAP1 and HLA-Cw6. J Invest Dermatol 131:S65-S65, Shaiq PA, Stuart PE, Raja GK, Voorhees JJ, Elder JT, Qamar R, Nair RP: Genetic associations of psoriasis in a Pakistani population. J Invest Dermatol 131:S63-S63, Swindell, WR, Xing X, Chen C, Nair RP, Voorhees JJ, Elder JT, Johnston A, Gudjonsson JE: Heterogeneity in the inflammatory network in chronic plaque psoriasis. J Invest Dermatol 131:S4-S4, Swindell WR, Johnston A, Carbajal S, Han G, Wohn C, Lu J, Xing X, Nair RP, Voorhees JJ, Elder JT, Wang X, Sano S, Prens EP, DiGiovanni J, Pittelkow MR, Ward NL, Gudjonsson JE: Genome-wide expression profiling of five mouse models identifies similarities and differences with human psoriasis. J Invest Dermatol 131:S3-S3, Tejasvi T, Chandran, V, Voorhees JJ, Gladman DD, Rahman P, Elder JT, Nair RP: TNFAIP3 polymorphisms and age at onset are associated with response to tumour necrosis factor blockade in psoriasis. Br J Dermatol 165:E9-E10, Nair RP, Ellinghaus E, Tsoi LC, Esko T, Tejasvi T, Chandran V, Pellett F, Peddle, L, Weichenthal M, Weidinger S, Mrowietz U, Balschun T, Metspalu A, Voorhees JJ, Abecasis GR, Rahman P, Gladman DD, Franke A, Elder JT: Replication of 18 psoriasis genetic associations in Caucasians. Br J Dermatol 165:E1- E1, Tsoi LC, Li B, Nair RP, Ding J, Gudjonsson JE, Stuart PE, Voorhees JJ, Tejasvi T, Kang HM, Abecasis GR, Elder JT: RNASeq reveals new insights into psoriasis biology, J Invest Dermatol 132:S6, Xing X, Riblett M, Kochkodan JJ, Nair RP, Voorhees JJ, Elder JT, Johnston A, Gudjonsson JE: The role of the IL12B associated psoriasis risk allele in the pathogenesis of psoriasis. J Invest Dermatol 132:S13, Tejasvi T, Stuart PE, Nair RP, Voorhees JJ, Elder JT: Prevalence of comorbidities is lower among HLA- Cw6-positive psoriasis patients. J Invest Dermatol 132:S46, Nair RP, Tsoi LC, Chandran V, Stuart PE, Tejasvi T, Voorhees JJ, Abecasis GR, Rahman P, Elder JT, Gladman D: Genome wide association analysis of psoriatic arthritis. J Invest Dermatol 132:S65, Johnston A, Xing X, Swindell WR, Kochkodan J, Nair RP, Stuart PE, Ding J, Voorhees JJ, Elder JT, Gudjonsson JE: Susceptibility-associated genetic variation at IL12B enhances Th1 polarization in psoriasis. J Invest Dermatol 132:S23, Xing X, Johnston A, Swindell WR, Stuart PE, Nair RP, Voorhees JJ, Elder JT, Gudjonsson JE: Opposing effects of the IL12B and IL23R psoriasis associated risk alleles on Th1 and Th17 responses in psoriatic skin. J Invest Dermatol 133:S41, Tejasvi T, Tsoi LC, Stuart PE, Nair RP, Voorhees JJ, Abecasis G, Elder JT: Transcriptome analysis reveals that severity of psoriasis is correlated with expression of genes involved in epidermal differentiation and proliferation. J Invest Dermatol 133:S185, Nair RP, Tsoi LC, Stuart PE, Chandran V, TejasviT, Ellinghaus E, Voorhees JJ, Weichenthal M, Franke A, Abecasis GR...: Meta-analysis of psoriasis and psoriatic arthritis identifies three new susceptibility loci. J Invest Dermatol 133:S136, Lambert S, Swindell WR, Tsoi LC, Drumright BL, Stoll SW, Nair RP, Elder JT: Gene expression signature of TRAF31P2-silenced keratinocytes reveals unexpected effects on KC differentiation and cytokine responses. J Invest Dermatol 133:S40, 2013.