Pain Therapeutics, Inc.

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1 Pain Therapeutics, Inc. Pioneers in Preventing Prescription Drug Abuse Remi Barbier President & CEO June

2 Forward-Looking Statements This presentation contains forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995, including statement about our prospects for growth, intellectual property protection, market size or growth, competitive position, regulatory agency action, and the anticipated development, timing, data readouts and therapeutic scope and value of our development stage products. You should not place undue reliance on these statements. These statements involve significant risks and uncertainties. Our results may differ materially from those contained in such statements, including, among others: our inability to protect our intellectual property rights and to have sufficient rights to commercialize our products; product competition; clinical trials of our products may fail or not initiated or conducted in a timely manner; our products may show insufficient therapeutic effects or unacceptable safety profiles; adverse decisions by regulatory authorities; existing preclinical and clinical data with respect to our products may not be indicative of future clinical or commercial results; unfavorable market launch of our product by Pfizer; reimbursement for our products; and the inability to manufacture successfully our products. Additional factors that could cause actual results to differ significantly from those projected in our forward-looking statement are discussed in our Annual Report on Form 10-K, Quarterly Reports on Form 10-Q and recent Current Reports on Form 8-K. Our forward-looking statements are based on our current beliefs and expectations and speak only as of the date of this presentation. We do not undertake any obligation to update any forward-looking statements. The term Abuse-resistance or Tamper-resistance as used in this presentation are not intended to designate an indication or a medical claim but rather a general description of agents designed to address the misuse, abuse and diversion of opioids. Oxycodone (CII) is a controlled-substance with high potential for abuse. The active ingredient in all opioids (including REMOXY) are highly addictive. 2

3 Pain Therapeutics Highlights Lead compound represents next-generation abuse-resistance Phase III efficacy study met all primary endpoints under an SPA Large target market ~$2.5 billion, with favorable demographics REMOXY Attractive deal economics, 15-20% royalty on net sales in the U.S. 3

4 Balanced Pipeline Registration Phase I/II Pre-clinical Three Undisclosed Assets in Pain and Other Indications. One Undisclosed Asset; Abuse-resistant Hydromorphone; Abuse-resistant Hydrocodone. REMOXY (oxycodone CII) 4

5 REMOXY - Product Overview A unique, extended-release formulation of oxycodone (CII) for patients with moderate-to-severe chronic pain. 1 Phase III achieved all clinical endpoints under an SPA Next-generation abuse-resistance technology designed to discourage common methods of tampering. Intellectual property protection beyond 2030 Large, established target market (~$2.5 billion) with demographics in favor of volume growth. (1) This is not intended to designate an indication or a medical claim but rather a general description of strong opioids designed to address certain types of clinical pain. Oxycodone (CII) is a controlled-substance with high potential for abuse. The active ingredient in all opioids (including REMOXY) are highly addictive. 5

6 An Attractive Partnership Pfizer has worldwide rights to REMOXY 1 $185 million cash received to date from partnership. $15 million milestone payment on FDA approval of REMOXY. 100% of R&D, commercial costs paid by Pfizer. (1) Except Australia & New Zealand. 6

7 An Attractive Partnership Pfizer has worldwide rights to REMOXY 1 $185 million cash received to date from partnership. $15 million milestone payment on FDA approval of REMOXY. 100% of R&D, commercial costs paid by Pfizer. 20% ROYALTY on net sales in the U.S., except as to the first cumulative billion in sales, where the royalty is 15%. 2 (1) Except Australia & New Zealand. (2) We will also receive a supplemental royalty equal to 6 to 11.5% of net sales, directly offsetting our financial obligation to one of our suppliers of excipients. 7

8 Pain Management Today Annual market for pain medications exceeds $7 billion; Over 27 million people have moderate-to-severe pain in U.S. MILD MODERATE SEVERE BREAK-THROUGH ORTHOPEDIC POST-OP SOFT TISSUE INJURIES BACK PAIN CANCER Acetaminophen COX-2 Inhibitor Hydrocodone Hydromorphone Oxycodone Morphine 8

9 Opioids For Pain Management 70 Global Opioid Consumption 6 principal opioids used to treat moderate to severe pain Oxycodone Source: Pain & Policy Studies Group (2013) 9

10 Opioid Misuse is Epidemic The World Health Organization estimates that approximately 2 million people in the U.S. alone are addicted to prescription opiates. An estimated 52 million people (20% of those age 12 and older) have used prescription drugs for nonmedical reasons at least once in their lifetime. Opiate dependency is estimated to affect nearly 10% of modern day medical practitioners. The problem is not limited to the medical community, first use of an opiate seems to be getting younger. 1 in 12 high school seniors reported past-year nonmedical use of the prescription pain reliever, Vicodin. Heroin is the most widely used illegal opiate 50% 40% 20% More than half of teens agree that prescription drugs are easier to get than illegal drugs. Almost 40% of teens don t perceive any great risk in trying heroin once or twice. Prescription opiate painkillers are just as prevalent, and just as dangerous 3 of 10 teens believe that prescription pain relievers are not addictive The total number of opiate prescriptions dispensed by retail pharmacies in the US rose from 76 million in 1991 to 210 million in

11 Regulators Are Committed Let me say, in no uncertain terms: the prevention of prescription opioid abuse is of the highest priority for the FDA. - April 2014 Margaret A. Hamburg, M.D., Commissioner of the U.S. Food and Drug Administration Prescription painkiller overdoses are a public health epidemic. Prescription painkiller overdoses killed nearly 15,000 people in the US in This is more than 3 times the 4,000 people killed by these drugs in Nov 2011 [Our]action plan primarily focuses on the growing and often deadly problem of prescription opioid abuse From 1997 to 2007, the milligram per person use of prescription opioids in the U.S. increased from 74 milligrams to 369 milligrams, an increase of 402 percent. Nov

12 Common Methods of Abuse VAPORIZE DISSOLVE FREEZE CHEW MICROWAVE SNORT CRUSH INJECT GRIND 12

13 1 st Gen Abuse Resistance Optimized to resist some methods of abuse VAPORIZE DISSOLVE FREEZE CHEW MICROWAVE SNORT CRUSH INJECT GRIND Examples: Crush-resistant polymer matrices ( hard shell ); sequestered antagonists ( beads ); gelling agents that prevent injection. 13

14 Next Gen Abuse Resistance REMOXY: Designed to resist all common methods of formulation abuse. VAPORIZE DISSOLVE FREEZE CHEW MICROWAVE SNORT CRUSH INJECT GRIND This is not intended to designate an indication or a medical claim but rather a general description of strong opioids designed to address certain types of clinical pain. Oxycodone (CII) is a controlled-substance with high potential for abuse. The active ingredient in all opioids (including REMOXY) are highly addictive. 14

15 A Gold Standard REMOXY may challenge market dynamics with a gold standard of abuse resistance VAPORIZE DISSOLVE FREEZE CHEW MICROWAVE SNORT CRUSH INJECT GRIND and help ensure patients in pain have appropriate access to opioid analgesics. 15

16 Phase III Design Under SPA Primary Endpoint - Pain Scores vs. Placebo 412 osteoarthritic patients, moderate-severe pain 12-Week treatment period 16

17 Mean Pain Intensity AUC Phase III Result Summary Mean Reduction of Pain Intensity Over 12 Weeks Placebo (N=205*) (p=0.007) Remoxy (N=201*) Achieved Primary Endpoint of pain reduction vs. placebo Quality of Analgesia and Global Assessment of medication were superior for REMOXY (p=0.004 and p=0.007) Most AEs were typical opioid-related AEs, mild and transient in nature 17

18 REMOXY Regulatory History REMOXY NDA submitted by PTI: June st Complete Response: Dec MANUFACTURING ISSUES 2 nd Complete Response: June MANUFACTURING ISSUES Pfizer has handled CMC remedial work, at its own expense. Pfizer obtained FDA endorsement of the REMOXY program in March 2013: In summary, it appears there is a regulatory path forward for REMOXY. 18

19 Pfizer s Press Release (excerpt) Pfizer Inc. Continues Development Program For Remoxy (oxycodone) Extended-Release Capsules CII October 22, Pfizer Inc. (NYSE: PFE) announced today that, having achieved technical milestones related to manufacturing, it will continue the development program for Remoxy (oxycodone) Extended-Release Capsules CII. Following guidance received from the U.S. Food and Drug Administration (FDA) earlier this year, Pfizer will proceed with the additional clinical studies and other actions required to address the Complete Response Letter received in June

20 Pfizer: NDA Re-filing mid-2015 Clinical Milestones Study Abuse Potential # Subjects 60 Est. Timelines On-going Pharmacokinetics Bioavailability 60 Dose Proportionality 18 Effects of Food 18 Mid-2014 Sources: ClinicalTrials.gov, May 2014 and Pfizer, Inc. 20

21 REMOXY Path To Market Market launch by Pfizer in the U.S., following FDA approval and risk-mitigation negotiations We believe REMOXY s unique chemical properties have potential to set a high bar for a gold standard of abuse-resistance in a $2.5 billion target market REMOXY is in Pfizer s Global Innovative Products unit Unit sales ~$12 billion in FY2014, most profitable segment Established relationships with health care systems, primary care providers & consumers Cornerstone pain drug brands include Celebrex & Lyrica 21

22 Efficient Capital Management ~ $47 million of cash & equivalents at Q ~ $12 million net cash use expected in 2014 ~ 45 million shares outstanding ~ 300,000 shares trade daily ~ $33 million NOL Management has ~ 30% ownership 22

23 Pain Therapeutics Highlights Lead compound represents next-generation abuse-resistance Phase III efficacy study met all primary endpoints under an SPA Large target market ~$2.5 billion, with favorable demographics REMOXY Attractive deal economics, 15-20% royalty on net sales in the U.S. 23

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