The Smart Dentin Grinder. Business Opportunity 2014

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1 The Smart Dentin Grinder Business Opportunity 2014

2 2 The Market Grafting Materials for Dental Reconstruction Currently a $550M global market An upcoming market, with 5.7% annual growth Tissue and Bone Regeneration Materials Include: Allografts: from human bodies Xenograft: from animals (bovine [cow], porcine [pig]) Synthetics: chemicals & minerals (hydroxyapatite, corals)

3 3 The Global Market GLOBAL MARKET FOR TISSUE AND BONE REGENERATION MATERIALS FOR DENTAL RECONSTRUCTION BY TYPE, THROUGH 2015 ($ MILLIONS) Product CAGR% Allografts Xenografts Synthetics Total Source: BCC Research

4 4 Market Opportunities Allografts Lead the Market The biggest market segment (50%) The fastest growth rate (6.2%) GLOBAL MARKET FOR ALLOGRAFTS, THROUGH 2015 ($ MILLIONS) CAGR% Product Allografts Source: BCC Research

5 5 Market Opportunities Autogenic Graft is better then all other Grafts Autogenic graft (Autograft) is a specific type of Allograft (human bone) It is collected from a patient and then applied for treating the very same patient Properties of various Osteoconductivinductive types of bone Osteo- graft sources Osteogenic 1 Alloplast + Xenograft + Allograft + +/ Autograft + + +

6 6 Market Opportunities Autogenic Graft is Currently the Gold Standard Autogenic grafts offer the best treatment results However, up until now, Autogenic grafts require a separate surgery for collecting bone from the patient Osteoconductive Osteoinductive Osteogenic Alloplast + Xenograft + Allograft + +/ Autograft + + +

7 7 The (New) Gold Standard Dentin - The Ultimate Autogenic Graft Dentin Autograft is produced from extracted teeth The chemical composition of Dentin is almost identical to that of the human bone. Still, Dentin is more solid than bone, and therefore it provides greater stability of the alveolar ridge. In addition, with dentin autograft, the alveolar ridge is absorbed in a very slow pace and it takes more than 6 years for its remodeling.

8 8 The (New) Gold Standard Dentin is Better then Bone Autogenic Graft Better Results Greater stability and treatment efficiency Longer alveolar ridge preservation Simplified Treatment No need for separate surgery for collecting bone Reduced treatment costs and shorter chair-time Saving unnecessary pain and recovery time See also: Scientific Articles about Dentin

9 9 Dentin Uses Dentin is the Optimal Graft for: Filling sockets after tooth extractions Alveolar bone preservation, anywhere in the jaw augmenting jaw bone and filling of bone defects ridge preservation and sinus lifting ridge augmentation for aesthetic purposes Supporting stability of implants including for immediate loading

10 10 Dentin and Implants Dentin Provides Perfect Support for Implants Greater stability for implants shortly after grafting, e.g. for immediate loading Reduced waiting time for delayed loading With Dentin, implants can withstand loading during mastication for longer periods

11 11 Yielding Dentin Dentin Graft is Produced from Extracted Teeth It is estimated that in the USA alone, over 20 million extracted teeth are disposed off every year Such extracted teeth can be used for yielding Dentin graft, in the following steps: Manual cleaning of the tooth Grinding the tooth Sorting (selecting proper size particles) Sterilizing with a cleansing solution

12 12 Yielding Dentin The Problem Lab Grafting Extracted teeth are delivered to a laboratory, grinded, cleansed, and then sent back to the dentist This process is already common in certain countries e.g. - Korea However, this process takes several days, required another visit to the dentist, and is not very efficient

13 13 Yielding Dentin The Solution Immediate Grafting Following extraction, teeth are being grinded and cleansed at the dentist s clinic, by the doctor or by his assistant The Dentin graft is instantly ready to use, and can be applied on the same visit This process requires a simple to use medical device, and this is exactly what we have invented

14 14 The Smart Dentin Grinder The Product 1 st generation launched in nd Generation soon to follow Based on our patented technology and includes our patented cleanser Already in use by many dentists great results & satisfaction

15 15 The Product The Smart Dentin Grinder Enables dentists to produce dentin autograft from extracted teeth within 15 minutes, in 3 quick steps: manual cleaning of the tooth automatic grinding and sorting by the Smart Dentin Grinder sterilizing with a designated cleansing solution. The resulted dentin autograft is free of bacteria and viruses, and can be immediately applied within a few minutes after the tooth is extracted. See also: The Smart Dentin Grinder - Video Guide

16 16 The Product The Smart Dentin Grinder - Grinding Clean Teeth are being placed in a disposable, single-use chamber for grinding and sorting The disposable chamber, in turn, is mounted on the Grinder s body.

17 17 The Product The Smart Dentin Grinder Grinding Using disposable chambers ensures that each treatment is fully autogenous. And, since the parts that come in contact with dentin are all disposable, the grinder is maintenance free. The consumable parts also contribute to the profit

18 18 The Product The Smart Dentin Grinder - Sorting The grinder automatically sorts the Dentin granules after grinding, keeping about 95% of the tooth volume The resulting autograft includes only dentin granules with a diameter between 300-1,200 microns. This is the optimal size, since smaller granules are engulfed by macrophages, and larger granules are inconvenient to work with and interferes with the integration process.

19 19 The Product The Smart Dentin Grinder - Cleansing The product kit comes with a unique cleansing (strong alkali) and a rinsing and neutralizing solution (PBS) Research has shown that the cleansing solution neutralizes germs, viruses, and fungi. Following the cleansing, when placing the dentin granules upon a bacterial substrate, there is no bacterial growth on it. In any case, there is no danger of infection, since the graft is autogenous

20 20 The Product The Smart Dentin Grinder - Product Kit Packed in a convenient suitcase, and includes: Fixed Equipment Grinder body, Hot Plate Consumable Parts for 3 Treatments Three disposable chambers (for grinding and sorting) Three glass containers (for cleansing and storing) Solutions for 10 treatments (Basic cleansing solution and rinsing and PBS neutralizing solution) Three droppers and a clamp See also: Product Manuals

21 21 The Product The Smart Dentin Grinder Consumables Kit Includes parts for 6 treatments: Six disposable chambers Six glass containers One 60 ml bottle of basic cleansing solution strong alkali (sufficient for about 10 treatments on average) One 100 ml bottle of rinsing and neutralizing solution PBS (sufficient for about 10 treatments on average) 2 droppers

22 22 Product Quality High Quality Production, in Taiwan Production under a ISO9001:2008 certificate Every grinder is tested for Proper function A two year warranty is offered

23 23 Certification CE Certification The grinder has a CE Approval as medical equipment The produced dentin is autogenous, therefore FDA approval is not required.

24 24 The Company Kometa Bio KometaBio is a dental biotech company, with R&D based in Israel, manufacturing in Taiwan, and marketing offices in Europe. We focus on developing advanced technologies that empower dentists in their everyday practice, and help them deliver better treatment in shorter chair-time. Established in 2012, our first breakthrough (the Smart Dentin Grinder) is soon to be followed by several other revolutionary solutions. Visit us at Kometa Bio s Web site

25 25 The Team An Outstanding Blend of Theory and Practice Strong scientific background in bone tissue engineering Extensive hands-on clinical practice Re-inventing the dental treatment time and again

26 26 The Management Meir Sahar, CEO Founder of CT Dent, a leading dental imaging services provider, with locations in Israel, UK and Russia Dr. Lari Sapoznikov, DMD, Clinical Advisor Inventor; Basal implantology specialist from University of Nice, France; Runs a private dental clinic in Tel-Aviv, Israel

27 27 The Management Prof. Itzhak Binderman, DMD, Scientific Advisor Former head of Dental Department and Hard Tissue Laboratory, Sourasky Medical Center Tel Aviv; School of Dental medicine & Department of Bio Engineering, Tel Aviv University; Senior Scientist and Consultant in the Department of Structural Biochemistry, Hospital for Special Surgery, NYC and Cornell Medical School, NYC; Visiting Scientist, National Institute of Health, NIDR, Bethesda, USA; Honorary Life Member of International Congress of Oral Implantology (ICOI).

28 28 The Management Ruben Tsaturian, Financial Advisor CFO at Kometa Healthcare IT Solutions, the leading medical imaging company specializing in PACS and 3D diagnostic workstations

29 29 Market Presence Current Distributors: CT Dent UK, United Kingdom Kometa Medical, Russia Divident, Israel Romana Enterprise, Taiwan

30 30 Market Segments for Dentin Advanced Dentistry Expert Dentists, including all those that: Work with implants and/or do various surgeries Get More for Less with the Smart Dentin Grinder: Offer the best treatment Save chair-time and costs See also: FAQ

31 31 Market Segments for Dentin Basic Dentistry General Dentists, including all those that: Extract teeth (& can now fill the sockets with Dentin) And do not work with implants Expand Their Business with the Smart Dentin Grinder: Enjoy a new source of (significant) income Earn much more on tooth extraction Enhance their professional image Before working with implants

32 32 The Opportunity We Have Already Established a Promising Market KometaBio already offers The Smart Dentin Grinder in several countries. This revolutionary device enables any dentist to produce the gold standard Dentin autogenic graft at his clinic, from extracted teeth, within minutes. This superior autograft can be immediately used for alveolar bone preservation and for implant support.

33 33 The Opportunity Now it s YOUR Turn to Expand this Market We are Looking for: Strong distributors in additional countries We prefer: A distributor that offers implants but also works with general dentists A leading global distributor, or a local reseller that is affiliated with a leading global distributor

34 34 The Opportunity And, in Turn, We Believe You will Thank Us As our Distributor, you are Likely to Enjoy: Loyal dentists, that have purchased the grinder and use its consumables regularly Significant and on-going revenues Market leadership New clients among the expert dentists Solid offering to general dentists Hassle-free operation and support

35 35 The Opportunity Your Clients will Thank You With the Smart Denting Grinder, You Can Offer Dentists: The best quality treatment Highly competitive prices Higher profits for expert dentists New sources of income & prestige for general dentists

36 36 The Opportunity And, in Turn, We Believe You will Thank Us As our Distributor, you are Likely to Enjoy: Loyal dentists, that have purchased the grinder and use its consumables regularly Significant and on-going revenues Market leadership New clients among the expert dentists Solid offering to general dentists Hassle-free operation and support

37 37 The Opportunity Why Should Nobel Biocare Be Interested in this? An Advanced and Highly Innovative Solution, that: Supports Nobel s position as market leader & innovator Provides improved quality of life to patients Offers excellent service to dentists Enables hassle-free Operational Excellency Revolutionizes a significant global market ($300M) Will increase the already rapid market growth (6.2%) With an opportunity to sell to general dentists as well

38 38 The Business Offer You Receive: Exclusive distribution rights in your territory Product Kits, Consumable Kits Supporting materials (manuals, articles, etc.) 2 year product warranty for end clients Initial Training and Support

39 39 The Business Offer Pricing Item Product Kit Consumables Kit Item Includes Suitcase, grinder, hot plate Consumables* for 3 treatments Nobel pays Reseller pays Dentist pays 480$ 960$ 1,440$ Consumables* for 6 treatments 180$ 360$ 540$ One Treatment Consumables* for 1 treatment 30$ 60$ 90$ *Consumables include: disposable chambers, glass containers, droppers, clamp, basic cleansing solution, neutralizing solution (PBS)

40 40 The Business Offer You Provide: Minimum orders per year for your territory Marketing efforts (plan, budget, sales force, training) Non-competition (related to dentin graft) Reporting (sales reports, feedbacks, biz intelligence)

41 41 Summary The Smart Dentin Grinder = Win-Win-Win Dentists get better results and simplified treatment Distributors get loyal clients, new clients, and growth KometaBio expands its global presence

42 42 Thank You! For further details: contact us

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