Biomedical Sciences. Manual (Modulhandbuch) Diploma of Advanced Studies (DAS) or Certificate of Advanced Studies (CAS) Juli/July 2012

Transcription

1 Biomedical Sciences Diploma of Advanced Studies (DAS) or Certificate of Advanced Studies (CAS) Albert-Ludwigs-Universität Freiburg Manual (Modulhandbuch) Juli/July 2012 University of Freiburg Prof. em. Dr. Drs. h.c. Roland Mertelsmann University Medical Center Dept. of Hematology and Oncology in cooperation with Freiburg Academy of Continuing Education (FRAUW)

2 UNIVERSITY OF FREIBURG... 0 FREIBURG ACADEMY OF CONTINUING EDUCATION PROGRAM STRUCTURE AND ORGANISATION RESPONSIBLE PERSONS... 2 METHODS OF INSTRUCTION AND STUDYING TECHNIQUES... 3 LANGUAGE FORM AND LENGTH OF THE PROGRAM Examinations and Grading DEGREE AND CREDITS OVERVIEW OF MODULES MOLECULAR & CELLULAR BIOLOGY (MODULE 1) IMMUNOLOGY & PATHOLOGY (MODULE 2) PHARMACOLOGY & TOXICOLOGY, MOLECULAR CARDIOLOGY AND MOLECULAR ONCOLOGY (MODULE 3) SPECIAL KNOWLEDGE FOR LIFE SCIENCES: MATERIALS & MICROSYSTEMS, STATISTICAL BIOINFORMATICS/MODELING IN SYSTEMS BIOLOGY (MODULE 4) LABORATORY RESEARCH 1 & 2 (MODULE 5) ADDITIONAL WORKLOAD Manual Biomedical Sciences 1

3 1. Program Biomedical sciences combine the knowledge and questions of experimental medicine with the methods of molecular biology and cell biology. This international program is designed as an intensive time of studies and research with a specific and practical training that qualifies for success in academia or the private sector. IMBS modules are treating following topics: Pharmacology and Toxicology, Materials and Microsystems, Molecular Medicine, Immunology, Pathology, Molecular Oncology, Molecular and Cellular Biology and an module in Statistical Bioinformatics. In addition, participants can chose a personal research project. Each research project is individually supervised and involves eight weeks of lab work, that is seven weeks of experimental work followed by week of data analysis and a written lab report in the format of a scientific research publication. The program is tailored to the interests of international graduate students with professional experience. Applicants should hold at least a Bachelor's degree or equivalent degree in biology, biochemistry, medicine, chemistry, or related fields Structure and Organisation 2.1. Responsible Persons Prof. em. Dr. Drs. h.c. Roland Mertelsmann, Scientific Director Registration, counseling, coordination: International Program in Biomedical Sciences (IMBS) Ms. Yvonne Weigand University Medical Center Freiburg, Dept. of Hematology and Oncology Hugstetter Straße 55, D Freiburg, Germany Tel.: +49 (0)761/ // Fax: +49 (0)761/ yvonne.weigand@uniklinik-freiburg.de Teaching Staff The teaching staff is composed of professors and lecturers of the Albert-Ludwigs-University and the University Medical Center of Freiburg/Breisgau as well as of the University of Furtwangen/Black Forest. 1 Master, Diploma or other foreign degrees Manual Biomedical Sciences 2

4 Methods of instruction and studying techniques Language English Presence lectures and classes group presentations practical lab-work Self Studies scientific reading preparation of presentations in groups preparation of intermediate exam practical lab-work consolidation of acquired knowledge 2.2. Form and Length of the Program Please note: according to the intensive format of a full time program (summer school) and in order to offer a highly flexible program, module sizes may differ from the usual extent. Modules off 2 CP, which is of 50 hours workload per week are offered as well as modules of 4 to 6 CP with a duration of 2 to 3 weeks of intensive course. An additional workload is mentioned for times of preparation and study concerning participants from abroad within the IMBS Summer School Program (see 3.5) Examinations and Grading Examinations: written exams written lab-reports Intermediate Exam oral exam (intermediate exam) Grading Scale: 1,0 / 2,0 / 3,0 / 4,0 / 5,0 (failed) 2.3. Degree and Credits The program concludes either with a Diploma of Advanced Studies "Biomedical Sciences" (DAS) or with a Certificate of Advanced Studies (CAS) "Biomedical Sciences according to the workload and number of modules the student chooses. Manual Biomedical Sciences 3

5 Diploma of Advanced Studies For DAS a total of 30 credit points (CP) in the European Credit Transfer System (ECTS) is awarded. Alternatively: Certificate of Advanced Studies For CAS a total of at least 10 credit points (CP) in the European Credit Transfer System (ECTS) is awarded. Credit Points: Requirements For being awarded credit points the following is required: - preparation according to the specifications and material provided by the professors - active participation in class - reading and self-study - active participation in group presentations - written and oral examinations Manual Biomedical Sciences 4

6 3. Overview of Modules Module 1: Molecular & Cellular Biology Module 2: Immunology and Pathology 2 Module 3: Pharmacology & Toxicology, Molecular Cardiology and Molecular Oncology Module 4: Special Knowledge for Life Sciences: (Materials & Microsystems; Statistical Bioinformatics/Modeling in Systems Biology) Module 5: Laboratory Research 1 & 2 2 CP 4 CP 6 CP 4 CP 14 CP 3.1. Molecular & Cellular Biology (Module 1) Lecturer: Prof. Dr. Christoph Borner There will be study of apoptosis in eukaryotic cells. Scientific methods will be explored: Individual bench work under supervision, statistical analysis, scientific lab report and critical evaluation of data. Learning Outcomes - Knowledge of cellular and biochemical methods on cellular models - Knowledge of rules and safety measure of lab work and ability to work under sterile conditions - Statistical analysis of the data - Proper logging a total workload of 50 hours, distributed over: Presence: 8,5 hrs/day: in the lab 42,5 hrs/week Self-Study: 1 h/day: data analysis and documentation and 2,5 5 hrs/week hrs/week reading 2,5 hrs/week Total per week: 50 hrs 2 Occasionally or alternatively offered: additional contents of Neurology Manual Biomedical Sciences 5

7 Credits: Immunology & Pathology (Module 2) This module contains two submodules: An immunologic submodule and a pathologic submodule. The immunologic submodule comprises lectures on special topics in advanced cellular and molecular immunology and pathology. It will show techniques in cellular immunology such as chromium release, proliferative assays and ELISPOT. It introduces also to multicolor flow cytometry (including practical exercises). Students will learn about tumor immunology, including antigens that can be recognized on human tumors; it will show development and recognition by mouse and human Natural Killer cells (NK cells) and bring light to the role of NK cells in graft-versus host disease. Other topics are allergic contact dermatitis, bacterial endotoxin and the innate immune system, the role of neutrophils in acute GvHD, regulatory T cells in human disease and antigen presentation as well as immune tolerance in the intestine. The pathologic submodule deals with the following: Clinical pathology diagnoses and classifies diseases based on histological, cytological and molecular methods to understand the principles and the development of diseases, f.ex. the causes of cancer, DNA repair and cancer, molecular cytogenetics of cancer, oncogenes and tumor suppressor genes, the cancer cell cycle and cellular immortalization and telomerase activation in cancer. This submodule will show signaling pathways in cancer as well as the spread of tumors. Apoptosis (molecular physiology and significance for cancer therapeutics), stem cells, hematopoiesis, leukemia and animal models of cancer are discussed. Lecturers Immunology: Prof. Dr. Paul Fisch Hans-Eckart Schafer Andreas Diefenbach Andreas Boehmler Beckman Coulter Stefan Martin Marina Freundenberg Robert Zeiser Reinhard Marks Philipp Rauf Thomas Boehm Pathology: Prof. Dr. Martin Werner Dr. Konrad Aumann Learning Outcomes Manual Biomedical Sciences 6

8 (1) - Participants have an overview of flow cytometry and understand the scientific presentation of flow cytometry data. They understand the role of different components of the immune system in human disease. - Evolution of adaptive immunity is a concept understood by participants. - Participants understand general principles of etiology and pathogenetics of diseases and the methods of pathological examination. - They are able to interpret the results of the examinations within an interdisciplinary context. (2) Participants have deeper knowledge on the following subjects: - Role of pathology - Methods in Pathology - Methods in Molecular Pathology - Immunological diseases - Hematological diseases - Tumorpathology - Neuropathology - Molecular genetics - Cellular adaptations, cell injury, and cell death - Acute and chronic inflammation - Tissue renewal and repair : regeneration, healing, and fibrosis - Hemodynamic disorders, thromboembolic disease and shock - Genetic disorders a total workload of 100 hours, distributed over: Presence: (1) 6 hrs/day: lectures/seminars 5 hrs/week: presentations by the students (20 minutes each) (2) 6 hrs/day: lessons 4 hrs/week: exam preparation 1 h/week: exam (1) 35 hrs/week (2) 35 hrs/week Self-Study (1) 5 hrs/week: self-study and preparation time of the own presentation 2 hrs/day: self-study (2) 2 hrs/day: self-study 13 hrs/week: self-study, preparation seminars (1) 15 hrs/week (2) 15 hrs/week Total per week: 50 hrs Credits: 4 Manual Biomedical Sciences 7

9 3.3. Pharmacology & Toxicology, Molecular Cardiology and Molecular Oncology (Module 3) The first part of this module offers basic and advanced knowledge about pharmacological studies of interaction between foreign substances (drugs) and organisms (biological systems). The second part of this module is focusing on recent key aspects of translational research in cellular and molecular biology and medicine. The participants will learn about basic immunologic and inflammatory mechanisms promoting atherosclerosis, and the metabolic syndrome as well as about the fundamental processes governing cardiac metabolism and dysfunction. They will learn about recent key aspects of translational research in cellular and molecular biology of cancer covering various areas of tumor genesis. Lecturers Pharmacology & Toxicology: Prof. Dr. Klaus Aktories Prof. Dr. Norbert T. Klugbauer PD Dr. Joachim Orth PD Dr. Ralf Gilsbach Prof. em. Dr. Dieter Meyer Molecular Cardiology: PD. Dr. Andreas Zirlik Dr. Dennis Wolf Dr. Sonja Hergeth Dr. Heiko Bugger Natalie Hoppe Alexandra Ortiz Molecular Oncology: Prof. Dr. Ralph Wäsch Prof. Dr. Monika Engelhardt PD Dr. Christine Dierks Dr. Milena Pantic Dr. Stefan Zimmermann Learning Outcomes (1) - Participants have knowledge of the mode of action of drugs and poisons, in order to allow a scientifically based, rational pharmacotherapy and treatment of poisoning. Receptor tyrosine kinases Bacterial toxins GPCR Signaling Voltage-gated ion channels GTPases - They have obtained knowledge of the mode of interaction of microsystems, surfaces and materials. (2) Participants know about basic molecular, inflammatory and immune mechanisms in atherosclerosis, the metabolic syndrome and cardiac energy metabolism / experience and in state-of-the-art techniques in the field. Manual Biomedical Sciences 8

10 (3) - Basic concepts and techniques in the field of molecular biology of cancer are understood. - Participants have the ability to get into specific topics of the field by reading current publications and to interpret and communicate the data, which should be applicable to other subjects in life science. a total workload of 150 hours, distributed over: Presence: (1) 3 hrs/day: Lectures and seminars 2 hrs/day: preparation of oral presentation 3 hrs/day: practical course: (2) 6 hrs/day: seminar (3) 8 hrs/day: lecture, group work, presentation Self-Study: (1) 2 hrs/day: self-study (2) 4 hrs/day: self-study estimated (3) 2 hrs/day: self-study (1) 40 hrs/week (2) 30 hrs/week (3) 40 hrs/week (1) 10 hrs/week (2) 20 hrs/week (3) 10 hrs/week Total per week: 50 hrs Credits: Special Knowledge for Life Sciences: Materials & Microsystems, Statistical Bioinformatics/Modeling in Systems Biology (Module 4) Special knowledge and state of the art methods are required to be able to do research in Biomedical Sciences. The first submodule will show the use of DNA-Chip for the detection of bacteria as well as protein adsorption to surfaces as observed by surfaces plasmons. Plasmons can be described as an oscillation of free electron density. Position and intensity of plasmon absorption and emission peaks are affected by molecular adsorption. Students will be watching cells on microstructured surfaces with the help of Atomic force microscopy (AFM) and they will be probing surfaces with small tips. Research laboratories organize journal clubs for all researchers in the lab to help them keep up with the literature produced by others who work in their field. Taking part in the journal club helps of the biomedical sciences program makes Manual Biomedical Sciences 9

11 participants become more familiar with the advanced literature and data in their field of study. This helps to rapidly improve the students' skills of understanding and debating current topics of active interest in their field. The second submodule deals with modeling and the application of statistical analysis methods in order to train the interpretation of the results. The course will teach the following: Multiple testing Unsupervised statistical learning Supervised statistical learning Lecturers: Materials/Microsystems: Prof. Dr. Jürgen Rühe Dr. Oswald Prucker Dr. Karen Lienkamp Statistical Bioinformatics: Prof. Dr. Matthias Kohl Learning Outcomes Dr. Holger Klapproth Dr. Thomas Brandstetter Prof. Dr. Knut Möller (1) Students gain individual laboratory skills. They become acquainted with the assessment and evaluation of scientific literature and also with interdisciplinary work. (2) Students know how important statistical analysis methods have to be applied and how the results have to be interpreted. Students will get familiar with open source statistical software for bioinformatics, i.e. the statistics software R (free, non-commercial implementation of statistical programming language S) and Bioconductor, using the R statistical programming language. a total workload of 100 hours, distributed over: Presence: (1) 4 hrs/day: laboratory work 3 hrs/day: lectures (2) 6 hrs/day: lectures Self-Study (1) 3 hrs/day: self-study (journal club work) (2) 4hrs/day: self-study, case-studies, exercises (1) 35 hrs/week (2) 30 hrs/week (1) 15 hrs/week (2) 20 hrs/week Total per week: 50 hrs Credits: 4 Manual Biomedical Sciences 10

12 3.5. Laboratory Research 1 & 2 (Module 5) Lab Research includes an intensive period of eight weeks respectively two times four weeks of laboratory work including documentation, self study and discussion on methods and results. Participants shall follow individual projects in their chosen laboratory/laboratories. Learning Outcomes Participants learn in depth about methods and documentation during hands-on work They should be able to adapt methods to specific questions. They understand all principles of laboratory work in the chosen laboratory/laboratories. 40 hrs/week: Laboratory work including documentation 3,5-4 hrs/week: Self-study and discussion 8 weeks (4 weeks) 320 hrs (160 hrs) 30 hrs (15 hrs) 350 hrs (175 hrs) Credits: Additional Total Intercultural Training and Scientific German Course Preparation for Intermediate Exam Intermediate Exam (one day) Two Weeks of Self Study (consolidation of acquired knowledge) Evaluation of the program and editing of final written report 48 hrs 40 hrs 10 hrs 50 hrs 02 hrs 150 hrs Manual Biomedical Sciences 11