CONFERENCE PROGRAMME

Transcription

1 CONFERENCE PROGRAMME 7:30am - 8:30am - 8:45am 8:45am - 9:30am 1:45pm 10:15am 10:15am - 11am 11am - 11:15am 11:15am - 12pm 12pm - 6:15pm - 1:30pm 1:30pm - 2:15pm 2:15pm 3:45pm 3:45pm 4:30pm Registration MONDAY, 14th December, Conference Room, John Paul II Hotel, 2 Św. Idziego Street Introductory remarks. Andrzej Lange, L. Hirszfeld Institute of Immunology and Experimental Therapy PAS/ Lower Silesian Center for Cellular Transplantation, Wroclaw, Poland Introductory lecture: Novel view on hierarchy of adult bone marrow stem cells and mechanisms regulating stem cell trafficking. Mariusz Z. Ratajczak, University of Louisville, USA/ Pomeranian Medical University, Poland Session 1. Mechanisms involved in somatic stem cell quiescence and mobilization Chairs: Mariusz Z. Ratajczak, Edward Scott Not all Hematopoietic Stem Cells regenerate equally: How HSC regulate scarification versus regeneration in vertebrate species. Edward W. Scott, University of Florida, Gainesville, USA Metabolic regulation of blood and bone forming stem cells by ROS and by Nitric Oxide. Tsvee Lapidot, Weizmann Institute of Science, Rehovot, Israel Mesenchymal stem cells of different tissue origin: the crosstalk between the MSCs and their local microenvironment. Diana S. Bugarski, University of Belgrade, Serbia The effects of pituitary-derived hormones on human stem and progenitor cell subsets. Marcin Moniuszko, Medical University of Bialystok, Poland Session 2. Organ specific stem cells Chairs: Marcin Moniuszko, Graca Almeida-Porada Plasticity of adult stem cells in endocrine and neural reconstitution. Nadir Askenasy, Schneider Children s Medical Center of Israel, Petach Tikva, Israel Ependymal stem cells based therapy. Miodrag Stojkovic, University of Kragujevac, Faculty of Medical Sciences, Centre for Molecular Medicine and Stem Cell Research, Kragujevac, Serbia Lunch & Posters Identification and modification of bone marrow-derived stromal cells for regenerative medicine. Graca Almeida Porada, Wake Forest University School of Medicine, USA

2 4:30pm - 5:15pm 5:15pm 6:00pm 7pm - 11pm Skeletal Stem Cells: Targets for enhancing bone formation. Moustapha Kassem, University Hospital of Odense, Denmark Human Mesenchymal Stromal Cells: Biological Properties and Clinical Application. Erdal Karaoz, Liv Hospital, Istanbul, Turkey Take Together to Appreciate Participants, Concert & Gala Dinner, Town Hall, Piwnica Świdnicka,14/15 Sukiennice Street Concert Program: Wacław z Szamotuł / Modlitwa, gdy dziatki spać idą Vytautas Miškinis / O sacrum convivium Arvo Pärt / Bohoroditse Djevo Felix Mendelssohn-Bartholdy / Richte mich Gott Moses Hogan / Hold on Camille Saint-Saëns / Oratorio de Noel ARS CANTANDI - WROCLAW UNIVERSITY of ECONOMICS CHOIR Conductor: Anna Grabowska Borys; Assistant: Magdalena Truszkowska Reut Monika Piechaczek (soprano) Marta Kilian (mezzosoprano) Marta Motkowicz (alto) Przemysław Borys (tenor) Jerzy Butryn (bass) Marta Komorowska (piano/organ) 7:30am - 8am 12am 8am - 8:45am 8:45am - 9:30am 10:15am Registration TUESDAY, 15th December, Conference Room, John Paul II Hotel, 2 Św. Idziego Street Session 3. Adult Tissue-Derived Mesenchymal Stem Cells Chairs: Barbara Łukomska, Hiroshi Mizuno Mesenchymal stem cells: possibilities and limitations in the application. Jasmin Nurkovic, State University of Novi Pazar, Novi Pazar, Serbia Regulation of inflammatory processes by bone marrow derived stromal cells. Eva Mezey, National Institutes of Health, Bethesda, USA Glioblastoma-mesenchymal stem cell communication modulates expression patterns of kinin receptors: possible involvement of bradykinin in information flow. Henning Ulrich, University of São Paulo, Brazil

3 10:15am 11:00am 11:00am - 11:45am 11:45am 12am 12:00pm 1:30pm Direct and/or indirect effect and the role of adipose-derives stem cells for tissue repair and regeneration. Hiroshi Mizuno, Juntendo University School of Medicine, Tokyo, Japan Mechanisms of action and bone forming capacity of human bone marrow mesenchymal stromal cells are donor dependent. Nathalie Chevallier, University of Paris-EST-Créteil, France Oral presentations Chairs: Aleksandra Klimczak, Diana S. Bugarski The effect of oral S1P receptor modulator (FTY20) on stem and progenitor cell mobilization in a murine model of sever colitis: implications for potential clinical application of FTY20. Wojciech Marlicz Karol Serwin Ewa Kubiś Sylwia Rzeszotek Magdalena Lewandowska Elżbieta Urasińska Mariusz Z. Ratajczak Presenter: Wojciech Marlicz, Pomeranian Medical University, Szczecin, Poland Analysis of smooth muscle regeneration in tissue engineered urinary bladder. Marta Rasmus Marta Pokrywczyńska Arkadiusz Jundziłł Karolina Warda Łukasz Buchholz Magdalena Bodnar Andrzej Marszałek Anna Helmin- Basa Jacek Michałkiewicz Maciej Gagat Alina Grzanka Tomasz Kloskowski Tomasz Drewa Presenter: Marta Rasmus, Nicolaus Copernicus University in Toruń, Ludwik Rydygier Collegium Medicum in Bydgoszcz, Poland The possibility of using the CD271+ and CD271- sub-populations of mesenchymal stem cells in intervertebral discs regeneration. Katarzyna Jezierska-Woźniak Paweł Wojtacha Aleksandra Habich Krzysztof Bladowski Monika Barczewska Joanna Wojtkiewicz Wojciech Maksymowicz Presenter: Katarzyna Jezierska-Woźniak, University of Warmia and Mazury, Olsztyn, Poland Isolation and phenotypical differences of MSC obtained from human bone marrow and skeletal muscle. Urszula Kozłowska Tomasz Jurek Magdalena Czuba Marta Rorat Aleksandra Klimczak Presenter: Urszula Kozłowska, Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Wrocław, Poland Intravenous injected mesenchymal stem cell-derived extracellular vesicles are localized in site of ischemic injury and improve blood flow recovery in vivo. Anna Łabędź-Masłowska Luisa Vergori Sylwia Kędracka-Krok Elżbieta Karnas Michał Sarna Ramaroson Andriantsitohaina Ewa K. Zuba-Surma Presenter: Anna Łabędź-Masłowska, Jagiellonian University, Krakow, Poland mrna-itga4 engineered human bone marrow mesenchymal stem cells for targeted delivery into the brain. Anna Andrzejewska Adam Nowakowski Miroslaw Janowski Sylwia Koniusz Piotr Walczak,Tomasz Grygorowicz Anna Jablonska, Barbara Lukomska Persenter: Anna Andrzejewska, Mossakowski Medical Research Centre, PAS, Warsaw, Poland

4 Haematopoietic fresh stem cells CD34 positive and joint cartilage treatment. Marek Krochmalski Witoński Dariusz Grzelak Piotr Persenter: Marek Krochmalski, Medical Magnus Clinic Lodz, Poland 1:30pm - 3:00pm 3:00 pm 5:45 pm 3:00am- 3:45pm 3:45 pm 4:15pm 4:15pm 5pm 5pm 5:45pm Lunch & Posters Session 4. Plasticity of stem cells and practical aspects of clinical translation Chairs: Ewa Zuba-Surma, Miodrag Stojkovic Better Manufacturing Practice for Cell Therapies, Kevin Murray, Biospherix, USA Hematopoietic stem/progenitor cells express several functional sex hormone receptors - novel evidence for a potential developmental link between hematopoiesis, VSELs and primordial germ cells. Magdalena Kucia, University of Louisville, Louisville, KY, USA Molecular and functional properties of murine and human VSELs continuum. Ewa Zuba-Surma, Jagiellonian University, Krakow, Poland Regeneration of Anti-Leukemic Activity in Patients Relapsing After AlloHSCT: The Possible Effect of Anti-Tyrosine Kinase Inhibitors Andrzej Lange, L. Hirszfeld Institute of Immunology and Experimental Therapy PAS, Lower Silesian Center for Cellular Transplantation, Wroclaw, Poland 9am- 9:15am 9:15am - 10am 10:20am - 1:30pm WEDNESDAY, 16th December, WORKSHOPS GMP Facility/Scientific-Medical Incubator of the Lower Silesian Centre for Cellular Transplantation 6 Gen. Augusta Emila Fieldorfa Street/ 18 Muchoborska Street Introduction, organizational aspects of workshops Andrzej Lange, L. Hirszfeld Institute of Immunology and Experimental Therapy PAS/ Lower Silesian Center for Cellular Transplantation, Wroclaw, Poland GMP facility how it looks like. Andrzej Lange, Agata Borowik, Jolanta Bochenska Lower Silesian Center for Cellular Transplantation, Wroclaw, Poland Mesenchymal stem cells propagation. Stefano Baila, TERUMO BCT We describe good manufacturing practices-compliant procedures for the production of ATMPs using the Quantum Cell Expansion System. The Quantum system is closed and automated medical device that has been successfully implemented in different manufacturing processes, form preclinical to clinical phases. Presented cases will address challenges and opportunities for cell and gene therapies manufacturing in the context of a closed and automated system. Additionally we will present how the system allows large-scale expansion of ATMPs while maintaining the critical quality attributes of interest.

5 1:30pm - 1:45pm 1:45pm - 4pm 10am - 5pm 4pm- Expanding T cells for therapy in a closed bioreactor system. Walter Kohler, Cell Therapy Technologies T cell therapies are a rapidly growing field of person medicine, but the large numbers of cells required present a logistical and technical challenge. Growing T cell in a XuriTM cell expansion system offers the benefits of being a closed, single-use and automated system in which high cell densities can be reached. Monitoring cell growth requires a sample to be taken from the culture, which briefly compromises the closed environment and risks the sterility of the culture. We show here how dissolved oxygen concentration acts as a surrogate readout for cell growth. Multi-omic transcriptomics & proteomics analysis. Danielle Fletcher, Agilent Technologies. During the workshop Danielle Fletcher will present unique features of Agilent s GeneSpring software that allow the combined analysis of transcriptomics and proteomics data. Participants will work on exemplary dataset and will conduct the complete workflow to obtain an integrated view on certain biological process. The aim of the workshop is to demonstrate that with proper bioinformatics tools the systems biology data analysis is at the reach of user s hand. farewell buffet