Curriculum Vitae Paola Causin

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1 Curriculum Vitae Paola Causin Dipartimento di Matematica F. Enriques Università degli Studi di Milano Personal data: born in Milano on Jan 12th, 1972 Present position (July ): Assistant Professor in Numerical Analysis (MAT08), Università degli Studi di Milano (Italy) Past positions Post-doc at École Polytechnique Fédérale de Lausanne, Chair of Scientific Computing prof. A.Quarteroni, Lausanne (Switzerland), Jan-Jun 2005 Post-doc at INRIA (Institut National de Recherche en Informatique et en Automatique) Rocquencourt in the framework of the European Project Research Training Network on Mathematical Modeling for Haemodynamics, Paris (France), Research fellowship, Politecnico di Milano, Milano (Italy), Education and Qualifications Jan 2003: PhD in Applied Mathematics (with honors), Università degli Studi di Milano, Italy 1999: Accreditation for the Italian Engineering Board : Master Degree in Aerospace Engineering (with honors), Politecnico di Milano, Italy Languages Italian: mother tongue; English: advanced; French: advanced; German: basic Visiting positions Visiting Scientist at the Dept. of Mathematics, Purdue University-Indiana University at Indianapolis (Indianapolis, USA), Aug-Sep 2011 Awards recipient of the prize Most Cited Author awarded by the journal Computer Methods in Applied Mechanics and Engineering,

2 SCIENTIFIC ACTIVITY Organization of scientific activities/editorial activity Organizer of the workshop Integrated multidisciplinary approaches in the study and care of the human eye. Clinical experience, mathematical modelling, new technologies, University of Milano and Politecnico of Milano, June 26-28th, 2013 Member of the Local Committee and Instructor of the ESSIM (part of the European Consortium Industrial Mathematics) Modelling Week, University of Milano, editions 2010 and 2011 Editor of the Volume of the Proceedings of the workshop Integrated multidisciplinary approaches in the study and care of the human eye. Clinical experience, mathematical modelling, new technologies, Kugler Publications, Amsterdam, The Netherlands, 2014 Reviewer for the journals Biomechanics and Modeling in Mechanobiology, Computer Methods in Applied Mechanics and Engineering Computers in Biology and Medicine European Journal of Lipid Science and Technology M3AS, Mathematical Models and Methods in Applied Sciences M2AN, Mathematical Modelling and Numerical Analysis Applied Numerical Mathematics Research papers papers with peer review procedure [P.1] P. Causin, E. Miglio, F. Saleri, Algebraic Factorizations for 3D Free Surface Flows, Comput Visual Sci 2002; 5(2):85 94 [P.2] P. Causin, E. Miglio, Parallel Computing for the Simulation of 3D Free Surface Flows in Environmental Applications, Recent Advances in Parallel Virtual Machine and Message Passing Interface, Lect Notes Comput Sc., ed. D. Kranzlmueller, Springer-Verlag Berlin 2002; 2474:78 87, [P.3] P. Causin, R. Sacco, A Dual-Mixed Hybrid Formulation for Fluid Mechanics Problems: Mathematical Analysis and Application to Semiconductor Process Technology, Comput Methods Appl Mech Engrg. 2003; 192: [P.4] P. Causin, R. Sacco, Mixed-Hybrid Finite Elements for the Simulation of Thermal Oxidation in Semiconductors, J Comp Appl Math 2004; 168(1 2): [P.5] P. Causin, R. Sacco, Mixed-Hybrid Finite Element Methods for Coupled Problems in Silicon Dioxide Technology, (2004), Scientific Computing in Electrical Engineering, Mathematics in Industry, Springer-Verlag 2004; 4: [P.6] P. Causin, M. Restelli, R. Sacco, A simulation system based on mixed-hybrid finite elements for thermal oxidation in semiconductor technology, Comput Methods Appl Mech Engrg. 2004; 193:

3 [P.7] P. Causin, R. Sacco, A Discontinuous Petrov Galerkin method with Lagrangian multipliers for second order elliptic problems, SIAM Jour Numer Anal. 2005; 43(1): [P.8] P.Causin, J.-F.Gerbeau, F.Nobile, Added-mass effect in the design of partitioned algorithms for fluid-structure problems, Comput Methods Appl Mech Engrg. 2005; 194(42-44): [P.9] P.Causin, N.D.dos Santos, J.-F. Gerbeau, C.Guivier, P. Métier, An embedded surface method for valve simulation. Application to stenotic aortic valve estimation, Mathematics and applications to biology and medicine, ESAIM Proc. 2005; 14: pp [P.10] P.Causin, R.Sacco, C.L.Bottasso, Flux-upwind stabilization of the discontinuous Petrov-Galerkin formulation with Lagrange multipliers for advectiondiffusion problems, M2AN Math Model Numer Anal 2005; 39(6) : [P.11] C.Carstensen, P.Causin, R.Sacco, A posteriori dual-mixed adaptive finite element error control for Lamé and Stokes equations, Numer Math. 2005; 101(2): [P.12] G.Aletti, P.Causin, Mathematical characterisation of the transduction chain in growth cone pathfinding, IET Syst Biol. 2008; 2: [P.13] G. Aletti, P. Causin, G. Naldi, A model for axon guidance: sensing, transduction and movement, AIP Proceedings, ed. L.M. Ricciardi et al. 2008; 1028: [P.14] P.Causin, G.Facchetti, Amplification and polarization in chemotaxis: addressing the specificity of neural cells via mathematical modelling and numerical simulation, PLOS Comput Biol 2009; 5(8): e [P.15] P.Causin, R.Sacco, Hierarchical Mixed Hybridized Methods for Elliptic Problems, Comp Meth Appl Mech Engrg. 2009; 198: [P.16] G. Aletti, P. Causin, G. Naldi, M. Semplice, Little Tom Thumb among cells: seeking the cues of life, MathKnow, Mathematics, Applied Sciences and Real Life, M. Emmer, A. Quarteroni Eds., Modeling, Simulation and Applications, Springer-Verlag Italia 2009; 3: [P.17] R.Sacco, P.Causin, M.T.Raimondi, P.Zunino, A multiphysics/multiscale 2D numerical simulation of scaffold-based cartilage regeneration under interstitial perfusion in a bioreactor, Biomech Model Mechanobiol. 2011; 10(4): [P.18] P. Causin, R. Sacco, A Computational Model for Biomass Growth Simulation in Tissue Engineering, CAIM 2011; 2(11):e370 [P.19] M. T. Raimondi, P. Causin, A. Mara, M. Nava, M. Laganà, R. Sacco. Breakthroughs in Computational Modeling of Cartilage Regeneration in Perfused Bioreactors. IEEE Trans Biomed Eng. 2011;58(12): [P.20] P. Causin, R. Sacco, M. Verri, A multiscale approach in the computational modeling of the biophysical environment in artificial cartilage tissue regeneration. Biomech Model Mechanobiol. 2013; 12(4):

4 [P.21] P. Causin, G. Guidoboni, A. Harris, D. Prada, R. Sacco, S. Terragni, A poroelastic model for the perfusion of the lamina cribrosa in the optic nerve head, Math Biosci. 2014; 257:33-41 papers under review procedure [P.22] P.Causin, C.Lelli, R.Sacco, Influence of the Stress State on in vitro Cartilage Growth: Mathematical Modelling and Numerical Simulation of Mechano- Physiological Processes, submitted to Journal of Theoretical Biology, 2014 [P.23] P.Causin, G. Guidoboni, F. Malgaroli, R. Sacco, A. Harris Multiscale Models and Numerical Simulation of Retinal Microcirculation: Blood Flow and Oxygen Transport, submitted to Biomechanics and Modeling in Mechanobiology, 2014 papers and conference proceedings without peer review procedure [P.24] P. Causin, E. Miglio, F. Saleri, A Parallel Finite Element Code for 3D Free Surface Flows, (2001), Scienza e Supercalcolo, CINECA, Settore Sistemi ad Alte Prestazioni, pp , ed. F. Garofalo, M. Moretti, M. Voli, ISBN [P.25] P. Causin, R. Sacco, Mixed-Hybrid Galerkin and Petrov-Galerkin Finite Element Formulations in Continuum Mechanics, Proceedings of the Fifth World Congress on Computational Mechanics (WCCM V), Editors: H.A. Mang, F.G. Rammestorfer, J. Eberhardsteiner, Publisher: Vienna University of Technology, ISBN , Vienna, Austria (2002) [P.26] P.Causin, R.Sacco, Hybridization of Galerkin and Petrov Galerkin mixed finite element methods for 2nd order elliptic problems, Atti del Convegno SIMAI 2006, maggio 2006, Baia Samuele book chapters [P.27] G.Aletti, P.Causin, G.Naldi, M.Semplice. A Multiscale Computational Model of Chemotactic Axon Guidance, (2011), in Liu, L. A., Wei, D., Li, Y., Lei, H. (Eds.), Handbook of Research on Computational and Systems Biology: Interdisciplinary Applications, pp , doi: / ch028 [P.28] M.T. Raimondi, P. Causin, M. Laganà, P. Zunino, R. Sacco, Multiphysics Computational Modeling in Cartilage Tissue Engineering, (2011), in Studies in Mechanobiology, Tissue Engineering and Biomaterials, 9, C. Baumann, Ed., Springer 4

5 PhD thesis [P.29] Mixed-Hybrid Galerkin and Petrov-Galerkin Finite Element Formulations in Fluid Mechanics, advisor: Prof. R.Sacco, University of Milano, (2003) didactical publications [P.30] P. Causin, S. Micheletti, R. Sacco, Introduzione all uso di MATLAB per il Calcolo Scientifico, (2000), in Italian, Technical Report n. 29/R, Dipartimento di Matematica F. Brioschi, Politecnico of Milano Conferences and seminars invited talks [C.1] Fluid Structure Interaction Simulation in Blood Flows: stability and accuracy issues, CEMRACS 2004, Mathematics and Applications in Biology and Medicine, Marseille, August 2004 [C.2] A Posteriori Dual-Mixed (Hybrid) Finite Element Error Control, presented at the minisymposium Error Controlled Adaptivity of Mathematical Models and Finite Element Approximations with Applications to Applied Mechanics, organized by Prof. E. Stein, Prof. J.T. Oden, Sixth World Congress on Computational Mechanics (WCCM VI), Bejing (China), 4 10 September 2004 [C.3] Numerical Aspects in Fluid Structure Interaction Simulation in Hemodynamics, minisymposium Mathematical Models in Biology, SIMAI 2004 Congress, Venice (Italy), September 2004 [C.4] A multiscale deterministic stochastic model of axon pathfinding in embryo development, conference Mathematics for Human Life and Environment, Montecatini (Italy), 29-31/03/07 [C.5] Towards the modelling of axon guidance: cues, gradient sensing and transduction process, Workshop on Neural Modelling, Istituto Italiano di Tecnologia, Genova (Italy), 15/10/07 [C.6] Autocatalytic Loop, Amplification and Diffusion: a Mathematical and Computational Model of Cell Polarization in Neural Chemotaxis, Workshop on Computational Biology in Neurosciences, Pavia (Italy), Sept 2009 [C.7] Multiphysics models in Tissue Engineering applications Italian French meeting on Biological Structures, Politecnico of Milano (Italy), 2010 [C.8] Mathematical Modelling in Life Sciences: the case of Tissue Engineering, Modelli Numerici per Equazioni Differenziali, in Una giornata in ricordo di Fausto Saleri, Politecnico of Milano (Italy), 01/12/2010 [C.9] Multiscale models of retinal microcirculation: blood flow and mass transport phenomena, Euromech Colloquium 2013, Genova, April 4-6/2013 [C.10] Influence of the stress state on in vitro regeneration of cartilage cells: mathematical modeling and numerical simulations, 11th World Congress on Computational Mechanics, to be held in Barcelona, July

6 contributed communications [C.11] Algebraic Factorizations for 3D Free Surface Flows, Congress SIMAI 2000, Ischia, Jun 2000 [C.12] A 3D Finite Element Code for Geophysical Flows, Congress SIMAI 2000 Ischia, Jun 2000 [C.13] The Discontinuous Petrov-Galerkin Finite Element Method, USNCCM VI, Sixth U.S. National Congress on Computational Mechanics, Dearborn, Michigan (USA), Aug 2001 [C.14] Mixed-Hybrid Finite Elements for the Simulation of Thermal Oxidation in Semiconductors, ACOMEN 2002, Liège (Belgium), May 2002 [C.15] A Parallel Finite Element Method for 3D Non-hydrostatic Flows, PVMM- PI 2002 Congress, Linz (Austria), Sept 2002 [C.16] Fluid structure interaction in blood flows, RTN HaeModel Meeting, Bergamo (Italy), May 2003 [C.17] The Discontinuous Petrov-Galerkin Finite Element Method: error analysis and computer implementation, USNCCM VII, Seventh U.S. National Congress on Computational Mechanics, Albuquerque (USA), Jun 2003 [C.18] Fluid-structure coupling in blood flow numerical simulation, Simposium of Modelling of Physiological Flows, Lausanne (Switzerland), Sept 2003 [C.19] A parallel-in-time scheme for fluid-structure interaction in blood flow, UMI Congress, Milano (Italy), Sept 2003 [C.20] Report on advances in fluid-structure interaction in blood flow simulation, RTN HaeModel Meeting, Graz (Austria), Apr 2004 [C.21] Added-mass effect in the design of partitioned algorithms for fluid-structure problems, to be presented at the minisymposium Computational Methods in Cardiovascular Bioengineering, organized by Prof. C. Taylor, WCCM VI Sixth World Congress on Computational Mechanics, Bejing (China), Sept 2004 [C.22] A fictitious domain approach for the simulation of heart valves, GNCS congress, Milano (Italy), 14-16/02/2006 [C.23] A Computational Model of Axon Growth, Biocomp 2007, Vietri sul Mare (Italy), 24-28/09/07 [C.24] A multiscale deterministic stochastic model of axon chemotaxis, congress Prospettive di Sviluppo della Matematica Applicata in Italia, Parma (Italy), 18-19/05/07 [C.25] Static condensation techniques for hybridized mixed FEMs, Seminario di Matematica Applicata, University of Milan (Italy), 16/10/06 [C.26] Hybridization of Galerkin and Petrov Galerkin Mixed Finite Element Methods for 2nd Order Elliptic Problems, VIII Congresso Nazionale SIMAI, Baia Samuele (Italy), 22-26/05/2006 [C.27] Little Tom Thumbs among cells: seeking the cues of life, MathKnow 08, Politecnico of Milan (Italy), 22-24/05/08 [C.28] Cell polarization in neural chemotaxis: mathematical modelling and numerical simulation, Trento (Italy), Dec

7 [C.29] Multiscale computational modelling in bioreactor tissue engineering: the biosynthetic response of cartilage cells to nutrient supply and fluid induced shear stress, ECCOMAS 2010, Paris (France), 16-21/05/2010 [C.30] Mathematical modeling of retinal circulation: fundamental mechanisms and impact on retinal diseases, CIMAB 2013, Milano, April 4-6/2013 Research projects member of Italian government funded projects member of the European Research Training Network Haemodel, member of the project 5 per 1000 Junior Application Multiphysics Computational Models for Advanced Tissue Engineering, awarded 2011 member of the PRIN2009 project (Italian government), awarded 2011 TEACHING/SUPERVISOR ACTIVITY PhD students [PhD.1] F. Malgaroli, Mathematical Engineering, Politecnico of Milano, Degree students [T.1] D.Villa, Studio di fattibilità riguardo la definizione di un modello real time per la simulazione di corpi deformabili, Degree Course in Computer Science, 2006 [T.2] S.Barbieri, Orientamento assonale in fase embrionale: un modello stocastico deterministico dal punto di vista microscopico, (co tutor) Degree Course in Mathematics, 2008 [T.3] G.Facchetti, Polarizzazione cellulare in fenomeni di chemiotassi del neurone: modellizzazione matematica e simulazione numerica, Degree Course in Mathematics, 2009 [T.4] D.Colombo, Un modello matematico per la simulazione della crescita di biomassa in Ingegneria dei Tessuti (co tutor), Degree Course in Mathematical Engineering, Politecnico of Milan, 2010 [T.5] A.Corno, Modelli ridotti di trasporto di massa in strutture biologiche porose, Degree Course in Mathematics, University of Milan, 2010 [T.6] F.Malgaroli, Tecniche di media volumetrica per il calcolo della diffusività effettiva in sistemi biologici, Degree Course in Mathematics, University of Milan, 2010 [T.7] L.Costa, Risoluzione Numerica di Equazioni di Diffusione in Presenza di Interfacce Materiali, Degree Course in Mathematics, University of Milan, 2010 [T.8] A.Rocca, Metodi matematici e computazionali per processi di Meccanotrasduzione cellulare, Degree Course in Mathematics, University of Milan,

8 [T.9] A.Minardi, Un approccio computazionale per il calcolo della conducibilit termica ecace in materiali compositi, Degree Course in Mathematics, University of Milan, 2011 [T.10] S.Valagussa, Modelli matematici per il metabolismo cellulare in ingegneria dei tessuti: dipendenza dal regime di sollecitazione meccanica, Degree Course in Mathematics, University of Milan, 2011 [T.11] L. Origgi, Mathematical and computational models for the study of autoregulation phenomena in the human retinal microvascular network, Degree Course in Mathematics, University of Milan, 2012 [T.12] F. Malgaroli, Multiscale models and numerical simulation of retinal microcirculation: blood flow and mass transport phenomena, Degree Course in Mathematics, University of Milan, 2013 [T.13] L.Sirtori, Computational Models of Cellular Mechanophysiology regulating Tissue Growth, Degree Course in Mathematical Engineering, Politecnico of Milan (cotutor), 2013 [T.14] S.Terragni, Poroelastic Computational Models of Biological Tissues, Degree Course in Mathematical Engineering, Politecnico of Milan (co-tutor), 2014 [T.15] C. Panizzi, Mathematical models of the autoregulatory response in arterial smooth muscle cells, Degree Course in Mathematics, University of Milan, 2013 [T.16] F. Zorzan, topic: mathematical and computational models of autoregulation processes in resistance vascular networks, Degree Course in Mathematics, University of Milan, expected degree date: summer 2014 [T.17] E.Pirovano, topic: mathematical models of ionic currents in the cell under asymmetrical external stimuli, Degree Course in Mathematical Engineering, Politecnico of Milan (co-tutor), 2014 [T.18] S.Pellegrini, topic: spatial dependent mathematical models of intracellular Ca 2+, Degree Course in Mathematical Engineering, Politecnico of Milan (co-tutor), 2014 [T.19] R.Colosio, Degree Course in Mathematics, University of Milano, expeted date: fall 2015 Teaching - Numerical Analysis, assistant, Politecnico of Milano, Degree Course in Aerospace and Mechanical Engineering, Years Numerical Methods for Engineering, assistant, Politecnico of Milano, Degree Course in Mechanical Engineering, Fall Elements of Fourier transform and functional analysis, assistant, Politecnico of Milano, Degree Course in Electronic Engineering, Fall Numerical Linear Algebra, assistant, University of Milano, Degree Course in Mathematics, Spring 2006, 2007,

9 - Introduction to Scientific Computing/Scientific Computing, assistant, University of Milano, Degree Course in Mathematics, Spring 2006, 2007, 2008, 2010, , Laboratory of Computational Mathematics, lecturer, University of Milano, Degree Course in Mathematics, Spring 2008, Numerical Analysis, lecturer, University of Milano, Degree Course in Computer Science, Spring 2005,2006, Numerical Analysis, assistant, University of Milano, Degree Course in Mathematics, Fall 2010, Fundamentals of Mathematics and Statistics, lecturer, University of Milano, Degree Course in Pharmacology, Fall 2009,2010,2011, Numerical Methods Partial Differential Equations 2, assistant, University of Milano, Degree Course in Mathematics, Spring 2011, 2012, 2013, 2014, 2015 COMMUNITY WORK Local representant of the ECMI (European Council for Mathematics in Industry) Educational Board Paola Causin Milano, June 9th,