Neurosciences (MSc) Vrije Universiteit Amsterdam - Fac. der Aard- en Levenswetenschappen - M Neurosciences

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1 Neurosciences (MSc) Vrije Universiteit Amsterdam - - M Neurosciences Vrije Universiteit Amsterdam - - M Neurosciences I

2 General information Biological Psychology studies the biological and genetic basis of human behavior. Theoretical knowledge of (molecular) genetics, neurophysiology and neuroanatomy is coupled to empirical research in population samples and in neurological and psychiatric patient groups. This yields an understanding of normal as well as abnormal brain function and behavior. A substantial part of your training is devoted to practical skills with the techniques of genetic and psychophysiological research. Our courses in behavioral genetics are unique in the Netherlands. During these courses you learn to examine the role of genetic and environmental factors on individual differences in personality, lifestyle, and mental and physical health. In the fields of behavior genetics and psychophysiology our department has a strong track record in training highly qualified scientific researchers. Job opportunities in these fields have been, and remain, very good. Bachelor Biological Psychology In the Bachelor program you will be extensively trained in three different research areas: - Cognitive Neuroscience: here you study the genetic architecture, in children, adolescents and adults of cognitive abilities, attention and memory processes. You learn how to assess intermediate phenotypes or "endophenotypes" such as electrophysiological indices of brain development, brain structure and function as assessed with MRI and neuropsychological testing. - Stress & Health: in this block you learn to assess cardiovascular functioning under laboratory and real life situations. The focus is on the sensitivity of the cardiovascular system to psychosocial stress, lifestyle (e.g. exercise) and genetic predisposition. You are trained to study behavioural and psychosocial risk factors, for instance smoking behaviour, physical exercise, work stress, and the hostility/depression cluster. - Genes & Behavior: in this block you study the genetics of variation in anxiety and depression and comorbid phenotypes in adults and the development of behavioural and emotional problems (e.g. attention problems, aggression and anxiety) in children. Large-size longitudinal survey studies focus on the development of psychopathology and on the genetic influences across the life-span in children and adults. You are trained to estimate the contribution of genetic variance to individual differences in these traits and to assess the etiology of comorbidity. Master of Neuroscience The bachelor degree in Biological Psychology guarantees admittance to the Master of Neurosciences program. The Neurosciences Master's program at the VU is a joint initiative by the of Earth and Life Sciences, the of Psychology and Education and the VU University Medical Center. The programme is unique in the Netherlands, due to its strong emphasis on genetics. It includes both fundamental and clinical aspects of the neurosciences, behavioural and quantitative genetics, as well as neurogenomics. The programme is embedded in the joint activities of the Institute for Clinical and Experimental Neurosciences (ICEN) and the Center for Neurogenomics and Cognitive Research (CNCR). The advantage of this Master's programme is that you always have access to experts within your chosen field, whichever specialization you opt for. These experts form part of national and international cooperative networks, so your studies need not be restricted to the VU. An updated schedule and program of the Master can be found at Each year over two million people in the Netherlands suffer from a disease or condition which affects the brain, including dementia, multiple sclerosis, Parkinson's disease, infarctions, tumours, epilepsy, addiction, schizophrenia and anxiety and mood disorders. If you opt for the Master's programme in Neurosciences, you will help push back the boundaries of our knowledge and develop strategies for treating and possibly even preventing these afflictions. The Master of Neurosciences program takes two full years and is accredited with 120 ECTS. All lectures, practicals, and written course materials are in the language Vrije Universiteit Amsterdam - - M Neurosciences II

3 Inhoudsopgave Expired course modules FALW - master programmes 1 MSc Neurosciences, year 1 1 Compulsary modules, first year 2 Individual work master FALW 2 MSc Neurosciences, year 2 2 MSc Neurosciences, Track Animal Behavioural and Systems Neurosciences 3 MSc Neurosciences, Track Clinical Neurosciences 3 MSc Neurosciences, General optional modules 3 MSc Neurosciences, Track Medical and Behavioural Genomics 4 MSc Neurosciences, Track Neurogenomics 4 Track Neurophysiology 4 MSc Neurosciences, Track Psychophysiology 5 MSc Neurosciences, Compulsary modules, second year 5 Vak: Advanced Clinical Neurosciences 5 Vak: Advanced Human Neurophysiology 6 Vak: Advanced Neurogenomics 7 Vak: Behavioral Genetics 8 Vak: Behavioral Genetics 9 Vak: Bioinformatics 10 Vak: Caput Community Genetics 11 Vak: Caput Institutionalising Participatory Approaches in the South 11 Vak: Clinical Neuroscience 12 Vak: Clinical neurosciences 13 Vak: Cognition and Attention 13 Vak: Community Genetics 14 Vak: Developmental Neurobiology of the Vertebrate Brain 15 Vak: Emotional and Cognitive Neuroscience 16 Vak: Experimental and clinical neuroendocrinology 17 Vak: Experimental neurophysiology 18 Vak: From Molecule to Mind 18 Vak: Functional Brain Imaging 19 Vak: Gene Hunting 20 Vak: Genomic Data Analysis 21 Vak: Gezondheidsjournalistiek (Health journalism) 22 Vak: Individual work master FALW 24 Vak: Individual work master FALW 24 Vak: Individual work master FALW 24 Vak: Interactive communication 24 Vak: Internship Neurosciences I 25 Vak: Internship Neurosciences II 25 Vak: Interpersonal Communication 26 Vak: Literature Survey Neurosciences 27 Vak: Literature Survey Neurosciences 27 Vrije Universiteit Amsterdam - - M Neurosciences III

4 Vak: Live Cell Imaging 27 Vak: Methods in Behavioral Neurosciences 28 Vak: Neuro- and Psychopharmacology 29 Vak: Neurobiology of Animal Behaviour 30 Vak: Neurogenomics 31 Vak: Neurogenomics 32 Vak: Neuroinformatics 32 Vak: Neuronal Networks in Vivo 33 Vak: Principles of Neuroscience 34 Vak: Psychophysiology 35 Vak: Quantitative Genetics 36 Vak: Quantitative Methods in Neuroscience and Genetics 37 Vak: Regional Hydrogeology and Groundwater Management 38 Vak: Scientific Writing in 39 Vak: Soil Vegetation Atmosphere Exchange 40 Vak: Statistical Genetics for Gene Finding 41 Vak: Sustainable Land Management 42 Vak: Synaptic and Cellular Neurophysiology 43 Vak: System Neurosciences 43 Vrije Universiteit Amsterdam - - M Neurosciences IV

5 Expired course modules FALW - master programmes The course modules presented in the list below will no longer be offered in academic year For some of these courses a final resit opportunity will be offered in academic year These course modules are: (details will follow). Courses: Name Period Credits Code Behavioral Genetics Period AM_ Caput Community Genetics 6.0 AM_ Caput Institutionalising Participatory Approaches in the South MSc Neurosciences, year AM_ Clinical Neuroscience Ac. Year (September) 5.0 AM_ Cognition and Attention Ac. Year (September) 5.0 AM_ Community Genetics Ac. Year (September) 6.0 AM_ Emotional and Cognitive Neuroscience Experimental neurophysiology Ac. Year (September) 4.0 AM_ Ac. Year (September) 6.0 AM_ Health Journalism Ac. Year (September) 6.0 AM_ Interactive communication 3.0 AM_ Interpersonal Communication 3.0 AM_ Neurogenomics 5.0 AM_ Neuroinformatics Ac. Year (September) 6.0 AM_ Principles of Neuroscience 6.0 AM_ Quantitative Methods in Neuroscience and Genetics Regional Hydrogeology and Groundwater Management Soil Vegetation Atmosphere Exchange Sustainable Land Management 5.0 AM_ Ac. Year (September) 6.0 AM_ Ac. Year (September), Period AM_ Ac. Year (September) 3.0 AM_ The Masters programme is worth 120 credits. The credits are divided over two years of study, each comprising 60 ECTS credits and can only be taken on a full-time basis. Students who take the masters programme in Neurosciences are eligible to sit the examination leading to the title of Master of Science in Neurosciences. The MSc Neurosciences does not have formal specialisations. First year students start the Master's programme with compulsory courses that aim to guide students through the broad field of neurogenomics, starting at the level of genes and extending all the way towards animal Vrije Universiteit Amsterdam - - M Neurosciences Pagina 1 van 44

6 and human behavior and back. The first year is finished with a research project. Programme components: - - MSc Neurosciences, Compulsory modules, first year Individual work master FALW Compulsary modules, first year Vakken: Naam Periode Credits Code Behavioral Genetics Period AM_1006 Clinical neurosciences Periode AM_1005 From Molecule to Mind Period AM_1004 Internship Neurosciences I Ac. Jaar (september) 30.0 AM_ Neurogenomics Periode AM_1007 Scientific Writing in Ac. Year (September), Period 2 Individual work master FALW 3.0 AM_ Vakken: Naam Periode Credits Code Individual work master FALW Individual work master FALW Individual work master FALW MSc Neurosciences, year 2 Ac. Jaar (september) 0.0 AME_001 Ac. Jaar (september) 0.0 AME_002 Ac. Jaar (september) 0.0 AME_003 Second year students can choose from a set of selected specialized courses. These optional courses are designed to deepen knowledge of certain areas. They cover both theoretical and practical aspects of the neurosciences. The choice of courses will depend on the students' interests and the focus of the research traineeships. Programme components: MSc Neurosciences, Track Behavioral and Systems Neurosciences MSc Neurosciences, Track Clinical Neurosciences MSc Neurosciences, general optional modules year 2 MSc Neurosciences, Track Behavioral and Medical Genomics MSc Neurosciences,Track Neurogenomics Vrije Universiteit Amsterdam - - M Neurosciences Pagina 2 van 44

7 - - - MSc Neurosciences, Track Neurophysiology MSc Neurosciences, Track Psychophysiology MSc Neurosciences, compulsory modules, second year MSc Neurosciences, Track Animal Behavioural and Systems Neurosciences Vakken: Naam Periode Credits Code Methods in Behavioral Neurosciences Neurobiology of Animal Behaviour Neuronal Networks in Vivo Semester 1, Period 2, Summer period Period AM_ Period AM_ MSc Neurosciences, Track Clinical Neurosciences 6.0 AM_1001 System Neurosciences Period AM_ Vakken: Naam Periode Credits Code Advanced Clinical Neurosciences Experimental and clinical neuroendocrinology Period AM_1014 Period AM_ Functional Brain Imaging Period AM_ Neuro- and Psychopharmacology Period AM_ MSc Neurosciences, General optional modules Vakken: Naam Periode Credits Code Advanced Neurogenomics Period AM_ Bioinformatics Periode AM_ Cognition and Attention Ac. Year (September) 5.0 AM_ Developmental Neurobiology of the Vertebrate Brain Experimental and clinical neuroendocrinology Experimental neurophysiology Period AM_ Period AM_ Ac. Year (September) 6.0 AM_ Vrije Universiteit Amsterdam - - M Neurosciences Pagina 3 van 44

8 Functional Brain Imaging Period AM_ Gene Hunting Period AM_ Live Cell Imaging Period AM_ Methods in Behavioral Neurosciences Neuro- and Psychopharmacology Neurobiology of Animal Behaviour Period AM_ Period AM_ Period AM_ Neuroinformatics Ac. Year (September) 6.0 AM_ Psychophysiology Period AM_ Quantitative Genetics Period AM_ Statistical Genetics for Gene Finding Period AM_ System Neurosciences Period AM_ MSc Neurosciences, Track Medical and Behavioural Genomics Vakken: Naam Periode Credits Code Gene Hunting Period AM_ Genomic Data Analysis Period AM_1008 Quantitative Genetics Period AM_ Statistical Genetics for Gene Finding Period AM_ MSc Neurosciences, Track Neurogenomics Vakken: Naam Periode Credits Code Advanced Neurogenomics Period AM_ Developmental Neurobiology of the Vertebrate Brain Track Neurophysiology Period AM_ Genomic Data Analysis Period AM_1008 Live Cell Imaging Period AM_ Vakken: Naam Periode Credits Code Vrije Universiteit Amsterdam - - M Neurosciences Pagina 4 van 44

9 Advanced Human Neurophysiology Period AM_1003 Live Cell Imaging Period AM_ Neuronal Networks in Vivo Semester 1, Period 2, Summer period Synaptic and Cellular Neurophysiology MSc Neurosciences, Track Psychophysiology 6.0 AM_1001 Periode AM_1009 Vakken: Naam Periode Credits Code Advanced Human Neurophysiology Experimental and clinical neuroendocrinology Period AM_1003 Period AM_ Functional Brain Imaging Period AM_ Psychophysiology Period AM_ MSc Neurosciences, Compulsary modules, second year Vakken: Naam Periode Credits Code Internship Neurosciences II Ac. Jaar (september) 30.0 AM_ Literature Survey Neurosciences Literature Survey Neurosciences Advanced Clinical Neurosciences Ac. Jaar (september) 8.0 AM_ Ac. Jaar (september) 12.0 AM_ nr Course code AM_1014 () Period Period 1 dr. J.J.G. Geurts Teaching method(s) Lecture, Study Group, Seminar The aim of the Advanced Clinical Neuroscience course is to teach how to design, to perform and critically evaluate clinical neuroscience in which the following concepts play an important role: 1) (endo)phenotyping; Vrije Universiteit Amsterdam - - M Neurosciences Pagina 5 van 44

10 2) systems/circuits in aging and cognition; 3) translational neuroscience (from molecule to mind; and from bedside to bench). Major neurodegenerative diseases like Alzheimer s disease, Parkinson s disease and Multiple sclerosis will be discussed in depth with a focus on the current challenge of developing efficacious therapies. The Advanced Clinical Neuroscience Course will cover the following topics: 1) New strategies and innovative approaches to improve diagnosing and phenotyping of Alzheimer, Parkinson or Multiple Sclerosis patients. 2) Systems and circuits in aging and cognition. 3) Translation neuroscience: what does the rat brain can tell us about the human mind. 4) Clinical epidemiology and statistics 5) How to design and perform clinical research with specific attention to neurodegenerative disorders and developmental disorders. The basic principles of and challenges in clinical research will be presented in a series of 8 lectures. Small groups will write a research proposal with focus on challenges in diagnosing and (endo)phenotyping patients with neurodegenerative or neurodevelopmental disorders. During the course, students will visit the Alzheimer centrum, Multiple Sclerosis (MS) centrum or Parkinson centrum to learn how neurophysiological testing, neuroimaging and other assessment contribute to diagnosis of neurodegenerative diseases. The students will have to study the papers and textbook chapters posted on the blackboard themselves. At the end of the course the students will present their research proposal. General attitude during the course (10%). Research report on specific problem concerning a partical neurological disorder (50%). Presentation of research proposal at the end of the course (40%). A number of relevant reviews posted on Blackboard. Principles of Neuroscience (AM_470701), Clinical Neuroscience (AM_ ) Remarks For further information and application, please contact dr. W.D.J. van de Berg Advanced Human Neurophysiology Course code AM_1003 () Period Period 2 Vrije Universiteit Amsterdam - - M Neurosciences Pagina 6 van 44

11 Teaching method(s) dr. K. Linkenkaer Hansen Lecture, Study Group, Computer lab 1. Insight in how the human brain generates scalp electroencephalographic (EEG) signals, both ongoing oscillations and event-related potentials (ERPs). 2. Practical skills in the measurement of EEG and ERP signals, in the analysis of these data, and the use of MATLAB toolboxes for these purposes. 3. The application of these techniques in various scientific and medical fields, including sleep research, brain-computer interfacing, and genetics. In plenary lectures we will cover - The generating mechanisms of EEG oscillations and ERPs. - The theory behind digital signal processing routines. This will include frequency decomposition of the EEG (Fourier analysis), timefrequency analysis (wavelet), filtering, and methods to quantify temporal and spatial correlations (Detrended Fluctuation Analysis and cross-channel synchrony). - Source localization of observed EEG/ERP signals in the brain. - Insights from EEG/ERP research into sleep, psychophysiology, and genetics of human brain function. The lectures are interspersed with practicals, where the students will learn: - To record data with state-of-the-art high-density EEG systems. - Advanced data analysis techniques to remove non-brain noise form EEG signals (Independent Component Analysis). - Signal analysis techniques such as filtering, Fourier and Hilbert transforms. - Data analysis techniques to quantify peaks and latencies in ERPs. - To quantify EEG with standard measures (EEG power, ERP amplitude and latency) and more advanced measures (Wavelet based time-frequency transforms, DFA, Synchronization, Phase Lag Index). - To control a computer with your mind using a brain computer interface. Written examination and independent EEG/ERP data collection and analysis during the practicals Steven J. Luck An introduction to the event-related potential technique (Boston: The MIT press) and selected papers. Recommended background knowledge To be announced Target group Masters and PhD students with interest in human brain function in general and EEG methodology in particular Advanced Neurogenomics Vrije Universiteit Amsterdam - - M Neurosciences Pagina 7 van 44

12 Course code AM_ () Period Period 1 prof. dr. M. Verhage This course aims to introduce modern techniques in the integrated Neurosciences via hands-on experience. The use of these techniques is embedded in short research projects and typically covers a number of steps: first clone a construct, than culture and tranfect a cell with this construct and finally analyze a functional consequences of this modification using functional assays. Alternatively, research projects may also start with the intact brain and then work down to the molecular networks of proteins and genes, for instance using proteomics and mrna expression profiling. Although centered around genomics, many functional assays are offered, from electronmicroscopy and protein chemistry to life cell imaging, electrophysiology and behavioural analyses. Various tools and technologies will be explained in supporting lectures and used in order to answer questions related to the function of genes in the nervous system and how they contribute to higher order processes important for functioning of circuitry or behavior. This is a largely practical course. You will be executing a small research project aimed at illustrating today's research into gene-function relations. The experiments involve gene expression analysis (transcripts, proteins), and genotypic and phenotypic analysis (genotyping, cell biology, behavior). Theoretical underpinning of concepts and methods will be achieved by using examples from recent literature. The Neurogenomics course (MN 1st year) is obligatory for this course. Lectures, discussion of papers, demonstrations, practicals Examination and presentations of the work performed. Evaluation on the basis of 2 oral presentations by the students and their performance during the practical work and during (plenary) discussions. To be distributed during the course Study: Bsc Biology, Biomedical Sciences, Psychology with profile Biological Psychology or Neuropsychology. Course: Neurogenomics (470706). Remarks Behavioral Genetics Vrije Universiteit Amsterdam - - M Neurosciences Pagina 8 van 44

13 Course code AM_ (450003) Period Period 3 Credits 5.0 R.S.L. Ligthart Teaching staff dr. C.M. Middeldorp, R.S.L. Ligthart Teaching method(s) Lecture, Computer lab To provide the Master of Neuroscience students with a solid basis in human behavior genetics and to provide an overview of empirical results. Behavior genetics focuses on the inheritance of individual differences in complex traits. Such traits are most likely influenced by multiple genetic and environmental factors. The effects of genetic and environmental factors may be additive or interactive and lead to individual differences in complex traits and diseases that are quantitative rather than qualitative. In this course theory and principles from population genetics and biometrical genetics will be introduced, including genetic and cultural inheritance of complex phenotypes. Designs of family, adoption and twin studies and their applications to variation in cognitive abilities, personality and psychiatric disease will be discussed. The advances in molecular genetics have generated substantial progress in identifying the genetic basis of heritable traits using linkage and genome-wide association approaches. Both approaches will be reviewed and illustrated using recent studies aiming to identify genes genes underlying the vulnerability for psychiatric disorders, such as schizophrenia and mood disorders. Practical exercises will guide the student through some of the available online tools that facilitate the interpretation of gene-finding studies. Lectures, computer practicals Written examination; open-end questions (50%). Practical assignments and papers during the course (50%). To be announced via Blackboard BSc Biology, Biomedical Sciences, Psychology with profile Biological Psychology or Neuropsychology Remarks Attending the practicals is compulsory Application: Course coordination Behavioral Genetics Course code AM_1006 () Vrije Universiteit Amsterdam - - M Neurosciences Pagina 9 van 44

14 Period Period 2 R.S.L. Ligthart Teaching method(s) Lecture, Computer lab To provide the Master of Neuroscience students with a solid basis in human behavior genetics and to provide an overview of empirical results. Behavior genetics focuses on the inheritance of individual differences in complex traits. Such traits are most likely influenced by multiple genetic and environmental factors. The effects of genetic and environmental factors may be additive or interactive and lead to individual differences in complex traits and diseases that are quantitative rather than qualitative. In this course theory and principles from population genetics and biometrical genetics will be introduced, including genetic and cultural inheritance of complex phenotypes. Designs of family, adoption and twin studies and their applications to variation in cognitive abilities, personality and psychiatric disease will be discussed. The advances in molecular genetics have generated substantial progress in identifying the genetic basis of heritable traits using linkage and genome-wide association approaches. Both approaches will be reviewed and illustrated using recent studies aiming to identify genes genes underlying the vulnerability for psychiatric disorders, such as schizophrenia and mood disorders. Practical exercises will guide the student through some of the available online tools that facilitate the interpretation of gene-finding studies. Lectures, computer practicals Written examination; open-end questions (60%). Practical assignments and papers during the course (40%). BSc Biology, Biomedical Sciences, Psychology with profile Biological Psychology or Neuropsychology Remarks Attending the practicals is compulsory Bioinformatics Vakcode AM_ (450003) Periode Periode 2 Voertaal Engels Faculteit Coördinator P. Heutink-Rizzu BSc Vrije Universiteit Amsterdam - - M Neurosciences Pagina 10 van 44

15 Caput Community Genetics Course code AM_ () prof. dr. M.C. Cornel Genetics and genomics may lead to a new understanding of genetic contributions to human disease and the development of rational strategies for minimizing or preventing disease phenotypes altogether. However, translation appears to lag behind: the new genetics will not revolutionize the way in which common diseases are identified or prevented. This course aims to give an overview of current and future applications of medical genetics/genomics in health care. The student analyses current debates on pros and cons of these applications, as well as scientific developments in genetics/genomics and Technology Assessment related to these potential applications. Existing genetic care in clinical genetic centres, genetic screening and prenatal diagnosis is studied. Future scenario's are debated, including the development of tailored prevention programs. From the British text book topics will be selected that are currently relevant for Dutch Health Care. Students analyse the state of affairs for these topics in the Netherlands, the stakeholders and parties involved in the debate, the positions taken by parties, to what extent an offer in health care exists or could be developed, what discussions are relevant, and report in a paper and oral presentations. Self study Presentations on book chapters and journal articles followed by discussions in small working groups Writing essay Paper (100 %); presence and participation in working groups Stewart A, Brice Ph, Burton H, Pharoah P, Sanderson S & Zimmern R. Genetics, Health Care and Public Policy Cambridge University Press. ISBN-13: Caput Institutionalising Participatory Approaches in the South Course code AM_ () Credits 3.0 dr. M.B.M. Zweekhorst Vrije Universiteit Amsterdam - - M Neurosciences Pagina 11 van 44

16 - To develop a detailed understanding of the importance of participation strategies for sustainable development - To understand the difficulties that have been identified for institutionalising interactive approaches within existing organisations - To obtain insight into different strategies to institutionalize interactive approaches. - To acquire knowledge on the learning organisation. During the past three decades participation has become increasingly visible as an issue in development. It is recognized that participation is a key element in poverty eradication and sustainable development. Methodologies to enhance participation are now commonly used in development projects and 'participation' has become a development orthodoxy. However, it is one thing to acknowledge the effectiveness of participatory approaches, but another to apply these approaches consistently over longer periods of time. This requires institutionalisation of these approaches within the organisations concerned, so as to build the necessary capacity. Most organisations are not well adapted to the application of participatory approaches. Some organisational change is therefore likely to be necessary if participatory approaches are to be institutionalised successfully. In this theoretical course you study in depth scientific literature about various theoretical concepts and practical experiences of institutionalisation processes of interactive approaches that were undertaken by organisations in the South. This theoretical course comprises self study. After a short introduction you study various scientific articles that are then critically analyzed. Individual assessment though an assignment Selected scientific articles. Target group Optional course for Master students Management, Policy Analysis and Entrepreneurship in health and life sciences (MPA), Societal differentiation of the Health, Life & Natural Sciences. Remarks Self study. Basic knowledge on organisation and management is required. For more information and application: Clinical Neuroscience Course code AM_ (450003) Period Ac. Year (September) Credits 5.0 Vrije Universiteit Amsterdam - - M Neurosciences Pagina 12 van 44

17 dr. J.J.G. Geurts To provide the Master student, independently of his/her primary training, with a solid basis in clinical neurological disease and neuropathology. Tissue handling and interpretation of different aspects of neurological disease (tissue, imaging, clinical history) will be taught and overall disease insight will be improved. We will focus on four commonly occurring neurological diseases; dementias, multiple sclerosis, white matter diseases in children and Parkinson's disease. The student will learn about general neurological and epidemiological models (prevalence/incidence of different conditions, diagnostic/prognostic process, treatment strategies, etc.). Imaging characteristics of the four different neurological conditions will be reviewed. Basic histochemistry techniques will be dealt with and students will visit the neuropathology lab unit. Practical training consists of brain cutting tutorials and tissue microscopy. During the practical sessions, clinical information and knowledge from the lectures will be implemented and tested interactively. In addition to neuroimaging and neuropathology data, we will provide if necessary/applicable electrophysiology data. The aim is to familiarize the students with clinical neuroscience literature. Common methods and statistics (effect size vs. statistical significance, phase I/IV, false positive-negative results, etc.) will be discussed. Lectures, practical sessions (microscopy), tutorials (brain cutting / neuroanatomy), visits (MRI and histology lab), interactive training (three days of workshops), case presentations Written examination (lectures and clinical line), presence and general attitude (practical sessions and workshops) To be announced BSc Biology, Medical Biology, Biomedical Sciences, Medicine, Psychology with profile Biological Psychology or Neuropsychology Clinical neurosciences Vakcode AM_1005 () Periode Periode 2 Voertaal Engels Faculteit Lesmethode(n) Hoorcollege, Practicum Cognition and Attention Vrije Universiteit Amsterdam - - M Neurosciences Pagina 13 van 44

18 Course code AM_ (470628) Period Ac. Year (September) Credits 5.0 dr. L.J.F.M. van Zoest To introduce students to the major research topics in the field of human attention and discuss experimental methods that can be used to investigate attentional performance This course reviews current theories of attention. Topics covered are the relative influences of goal-driven and stimulus-driven control in attention, the relationship between attention and eye movements, dualtask performance, attention and memory, attention and inhibition, crossmodal attention, and the cognitive neuroscience and neuropsychology of attention. Emphasis will be placed on the different experimental designs that can be used to study attention. Lectures and class discussions. Students are expected to be prepared to discuss the literature assigned for each class. Written examination: open end questions To be announced on Blackboard Community Genetics Course code AM_ () Period Ac. Year (September) prof. dr. M.C. Cornel Teaching staff dr. C.G. van El Teaching method(s) Lecture, Study Group Genetics and genomics may lead to a new understanding of genetic contributions to human disease and the development of rational strategies for minimizing or preventing disease phenotypes altogether. However, translation appears to lag behind: the new genetics will not revolutionize the way in which common diseases are identified or prevented. This course aims to give an overview of current and future applications of medical genetics/genomics in health care. The student analyses current debates on pros and cons of these applications, as well as scientific developments in genetics/genomics and Technology Assessment Vrije Universiteit Amsterdam - - M Neurosciences Pagina 14 van 44

19 related to these potential applications. Existing genetic care in clinical genetic centres, genetic screening and prenatal diagnosis is studied. Future scenarios are debated, including the development of tailored prevention programs. From the UK textbook topics will be selected that are currently relevant for Dutch health care. Students analyse the state of affairs for these topics in the Netherlands, the stakeholders and parties involved in the debate, the positions taken by parties, to what extent an offer in health care exists or could be developed, what discussions are relevant, and report in a paper and oral presentations. self study Presentations on book chapters and journal articles followed by discussions in small workgroups Writing essay Lectures Paper (50%) and oral presentation (10%), exam with essay questions (40%) Stewart A, Brice Ph, Burton H, Pharoah P, Sanderson S & Zimmern R. Genetics, Health Care and Public Policy Cambridge University Press. ISBN-13: Other literature will be available at Blackboard. Volksgezondheid en Genetica (BSc, ) is highly recommended to know the basic principles of genetics at the start of the course. In case of uncertainty, please contact the lecturers. Remarks Taught in unless no non-dutch students are present. For further information please contact Martina Cornel Developmental Neurobiology of the Vertebrate Brain Course code AM_ () Period Period 2 dr. R.F.G. Toonen Teaching staff J.P. Weber Teaching method(s) Lecture This course will give insights in the developmental mechanisms of neural circuits and their plasticity during early and late brain development. The following issues will be covered: Molecular mechanisms of general and brain development, positional information systems such as the hox genes, mitogenic activity of embryonic and adult stem cells in relation Vrije Universiteit Amsterdam - - M Neurosciences Pagina 15 van 44

20 to neurogenesis, neuronal migration, neuronal differentiation, axonal growth, synapse formation, critical periods of development and experience dependent plasticity during embryonic and adult life. These topics are discussed while considering the adequate research technology and will be addressed during hands-on lab work using cultured neurons. Lectures, seminars, master classes. The first two weeks will be shared with the Master Developmental Biology and will consist of lectures on general developmental biology in the first week and developmental neurobiology in the second. The last two weeks will focus on master classes and hands-on training on early development of neuronal networks in culture. In the last week, students will present on specific topics in developmental neurobiology. Written mid-term exam (40%). Oral presentation of seminar task (30%). Presentation of labwork (30%) Handouts will be distributed at the beginning of the course Neurobiology, Molecular Developmental Biology Remarks Maximum number of students is 24. For further information and application, please contact: Dr. R. Toonen Emotional and Cognitive Neuroscience Course code AM_ () Period Ac. Year (September) Credits 4.0 Knowledge of the most important psychiatric disorders and basic aspects of underlying emotional and cognitive dysfunctions. After a general introduction, there will be a special session on how to perform a psychiatric investigation and how to obtain a biography. The focus of the course will be on depression and anxiety disorders, addiction, bipolar disorder, schizophrenia, PTSD, delirium, and neuroimaging of psychiatric disorders. In these sessions, we will discuss both clinical aspects, using video demonstrations, and basic aspects, using the corresponding chapters from Principles of Neural Science (see below; ch en ch ) During the sessions we will judge on active participations by the individual students. During the final session there will be an examination on paper. Vrije Universiteit Amsterdam - - M Neurosciences Pagina 16 van 44

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