CorCell Stem Cell Banking. Protecting Your Family s Health

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1 CorCell Stem Cell Banking Protecting Your Family s Health

2 DEAR EXPECTANT PARENTS, Thank you for your interest in CorCell, and congratulations on the upcoming birth of your child. The day your child is born is a momentous occasion, and your child s continued excellent health is of primary importance. If your child s health becomes compromised, having options is important. Saving your baby s umbilical cord stem cells can give you those options. The regenerative cells found in your baby s umbilical cord can treat many life-threatening diseases, and ongoing stem cell research is uncovering more treatment possibilities every day. The bottom line... CorCell offers you peace of mind. This booklet should answer most of your questions about CorCell and stem cell banking and includes all the information you need to enroll. You can find more information at or by calling our 24-hour customer care center at (888) 882-CORD(2673) with any questions. Congratulations again on taking this first step toward helping secure your baby s tomorrow. Best wishes to you and your family s future, Joseph Vicente President, CorCell Companies, Inc.

3 BE PROACTIVE WITH YOUR CHILD S HEALTH Your baby s umbilical cord is an amazing source of powerful stem cells, which are the building blocks of your body. Saving these stem cells gives your child options when it comes to treating illness and access to any future treatments that may arise through emerging research. CORD BLOOD BENEFITS Cord Blood Stem Cells, A Life-Saving Resource for Disease Treatment Hematopoietic stem cells from cord blood have been used since 1988 to treat more than 80 life-threatening diseases, such as leukemia, anemia, non-hodgkin s lymphoma, other cancers and impaired immune systems. Research is pushing for more treatments every day. Cord blood stem cells save lives, and these stem cells are being researched to treat diseases that currently have no cure. Your Baby s Own Stem Cells Should your child require them, his or her own stem cells will always be a perfect match, meaning that there will be no time lost waiting for a donor or sitting on a transplant list while your child s condition worsens. Treatment time may be faster, and there is little chance of rejection, which dramatically increases the chances of a successful stem cell transplant. A Potential Match For Another Family Member If a family member s health is compromised, using your own family s stem cells instead of those from an unrelated donor can be advantageous. Siblings have a 25% chance of being a perfect match and a 50% chance of being a partial match. In addition, studies show that patients using cord blood from a related donor have a higher survival rate than those who receive stem cells from an unrelated source. Our son Jake was born with Bladder Extrophy, a rare birth defect. In the future Jake s stem cells may be able to be used for reconstructive repair to grow his own tissue, something his body won t reject because it is his own. This could mean a world of difference for the quality of life our son will have, and for that I am eternally grateful that we took the step to save his cord blood with CorCell. Sandra Gallagher-Mohler Maryland

4 WHY CORD BLOOD BANKING

5 Cord Blood Stem Cells Save Lives Use of umbilical cord blood as an alternate source of hematopoietic stem cells continually increases. To date, there have been over 30,000 cord blood transplants worldwide, and over 20,000 Americans have been saved by a cord blood transplant.* Our daughter Holland was born three years ago and we banked her cord blood with CorCell without thinking twice. I have Lupus and my daughter could inherit the Lupus gene you never know what may happen. Heather Murray Texas CorCell.com For information on CorCell s advantages, collection and storage process, medical benefits, insurance partners and more, visit For a more detailed list and information about diseases treated, visit www. CorCell.com or www. clinicaltrials.gov Transplant Medicine: Current Diseases Treated Blood Cancers (Leukemia, Lymphoma, Myeloma) Blood Disorders (Sickle Cell Anemia, Aplastic Anemia, Fanconi Anemia) Tumors (Neuroblastoma) Immune Disorders (SCID, Wiskott-Aldrich Syndrome) Cord Blood Stem Cells Hold Significant Promise For the Future. Today, there are more than 10,000 stem cell clinical trials occurring around the world to address pervasive conditions such as cerebral palsy, heart disease, diabetes, lung disease, liver disease, lupus, Alzheimer s disease, multiple sclerosis, muscular dystrophy, Parkinson s disease, rheumatoid arthritis, spinal cord injury, stroke and more. WHY CORD BLOOD BANKING Emerging Cord Blood Research Autism (1 in 88 children are diagnosed in the United States.) Brain Injury (Leading cause of disability and death in children and adolescents nationwide.) Cerebral Palsy (Leading cause of childhood onset disability) Type 1 Diabetes (15,000 children are diagnosed every year) Juvenile Onset Diabetes * SOURCE: 4/14/2005

6 MEDICAL ADVANCEMENTS My mom was dying of ovarian cancer and decided that saving her grandchild s umbilical cord blood would be her gift to him. Since there is familial history of blood-related and other cancers in both mine and my husband s families, we decided to save all of our children s umbilical cord bloods. Maria Ydrach Puerto Rico

7 Preparing for the Future: Cord Tissue Stem Cells The power of stem cells does not stop at cord blood. A second stem cell type, called a mesenchymal stem cell, can be found in the tissues surrounding the umbilical cord veins and arteries. These stem cells differentiate into the body s connective tissues, which means that they can repair the body in different ways. There are over 200 clinical trials exploring the potential of cord tissue stem cells. Saving them with CorCell ensures that your family will have access to this emerging medical resource. Mesenchymal Stem Cell Potential Treatments Autoimmune diseases Skeletal diseases Ligament injury Diabetes Save both Cord Blood and Cord Tissue for More Options Cord Tissue Mesenchymal Stem Cells Creates connective tissues, including nerves, bones, muscles, ligaments. Being evaluated for regenerative therapies, including treatments for Alzheimer s, Arthritis, Stroke and Heart Disease. Easy to expand and refreeze, giving a potentially limitless supply. Neurological diseases Alzheimer s (1 in 3 seniors die with Alzheimer s or related dementia) Heart Disease (leading cause of death in the United States) Arthritis (1 in 5 Americans report having doctor-diagnosed arthritis) Cord Blood Hematopoietic Stem Cells Creates blood and immune system cells. Used in transplant medicine since Can currently treat over 80 life-threatening diseases. Being researched to treat conditions such as autism, brain injury, hearing loss, and type 1 diabetes. MEDICAL ADVANCEMENTS Cells do not cause an immune system response. Therefore, they can potentially be used for the entire family. 100% match for baby, potential match for family members. Storing Cord Tissue with CorCell CorCell gives your family a variety of options when it comes to saving this valuable stem cell. Save Cord Tissue Segment A segment of your baby s cord tissue is cryogenically preserved, safeguarding the stem cells within. This preserves other cells within the cord that may have restorative properties. 1 National Marrow Donor Program, 2009 Report to the Community

8 A STEM CELL LEADER

9 Stem cell research has grown dramatically over the past few years,. When it comes to cord blood and cord tissue banking, I believe that all expectant parents should be aware of their options as well as disease treatment possibilities. As CorCell s Tissue Bank Director, with over 30 year s experience in both clinical bone marrow transplantation and cord blood banking, I am committed to ensuring that each stem cell collection at Corcell is processed and stored to the highest standards in the industry. Dr. Geoffrey J. O Neill CorCell s Tissue Bank Director A LEADER IN STEM CELL COLLECTION AND STORAGE Founded in Philadelphia, PA, the CorCell Program was one of the first licensed private cord blood programs in the United States. CorCell has been dedicated to private cord blood banking since From collection to processing, storage, and retrieval for transplant, CorCell s process is unparalleled. Our state-of-the art facilities, experienced professionals, proprietary process that exceed government standards and futureoriented philosophy ensure that your child s stem cells are in the safest hands possible and prepped for use in forthcoming therapies. A STEM CELL LEADER We are committed to the highest ethical standards in serving our customers. As an industry leader, CorCell has collected umbilical cord blood stem cells from thousands of hospitals nationwide and around the world. We have a successful track record of cord blood transplants. In fact, one of CorCell s stored specimens was used in the first known autologous transplant for childhood leukemia.* OUR CREDENTIALS At CorCell, we take our credentials very seriously. Having third party verification of our processes is very important when it comes to ensuring quality. Registered with the FDA to serve as a cord blood bank. Accredited by the American Association of Blood Banks (AABB). Operating under current Good Tissue Practice (cgmp). Testing conducted by CLIA approved, licensed reference laboratories. Licensed as a Tissue Bank in the states of New York and California. * SOURCE: The Official Journal of the American Academy of Pediatrics. (2007). First report of autologous cord blood transplantation in the treatment of a child with leukemia. Pediatrics, 2007 (119),

10 CORCELL ADVANTAGES

11 WHY PARENTS CHOOSE CORCELL Storing Cord Blood and Cord Tissue With CorCell Proper processing of stem cells makes all the difference. Our trained technicians oversee the processing of your baby s stem cells from start to finish. Every stem cell sample is unique and requires an individual approach to obtain the most stem cells possible. Obstetricians find our Collect-A-Cord kits safe, reliable and easy to use. Our courier transports your baby s cord blood to our laboratory, under time and temperature guidelines, where it is tested according to FDA cellular therapy protocols. Initial cord blood collection volume averages ml and after processing is complete, your stem cells are stored in a 25 ml multi-compartment cryobag. Cells are stored at -195 C in our cryogenic storage tanks. Finally, your baby s cord blood and cord tissue stem cells are cryopreserved and then stored in our experienced, licensed, secure, cutting-edge cord blood banking facility with around the clock monitoring. Looking Towards the Future: Cellular Engineering CorCell s dedication to future cellular therapy means we process to the highest standards. All specimens are tested to ensure the stem cells meet the rigid standards for transplantation or other therapeutic use. They are evaluated for bacterial contamination and infectious disease. Also, the number of stem cells and CD34 cells are counted both before and after processing. CORCELL ADVANTAGES Stem Cell Collection is Only Four Easy Steps 1.Receive Collect-A-Cord Kit 2. Place In Your Overnight Bag Can be shipped overnight. Ensures easy access when required. Contains instructions for parents and obgyn. 3. Doctor, Nurse or Midwife Collects Cord Blood, Cord Tissue Segment Process takes only 5 minutes. 4. Contact Courier Number on the Kit Courier transports to CorCell s lab where stem cells are processed within 48 hours of collection. Followup call from our team letting you know the results.

12 COLLECTING CORD BLOOD With colon, ovarian, prostate and breast cancers on both the maternal and paternal sides of the family, we wanted to be proactive in the event we would have to tap into the umbilical cord blood for stem cells. We are thankful to be a CorCell customer. Anthony D Eramo Indiana

13 Your Doctor s Role CorCell s collection procedure is preferred by obstetricians for its safety, reliability and simplicity. 1. The doctor or nurse will draw blood from the mother for hospital use as well as for infectious disease testing by our lab. 2. After the umbilical cord is cut, your doctor or nurse will collect the cord blood into a sterile, closedsystem bag that has the least chance of contamination. A section of cord tissue is also collected. 3. They will return the collected cord blood and/or tissue to you in the Collect-A-Cord kit for courier pickup. COLLECTING CORD BLOOD Collect-A-Cord kit Our Collect-A-Cord features the PALL Medical Cord Blood Sterile Collection Bag. This innovative sterile bag makes it safe for all deliveries, including C-sections. No need for additional sterile adapters. The bag is designed to maximize the recovery of cell-rich plasma and accommodates cord blood volumes of up to 210 ml. This collection bag also features an In-line DonorCare needle guard, ensuring safer cord blood collection by providing an added level of safety for collection staff against accidental needlestick injuries. The Pall bag is FDA NDA approved and individually inspected prior to release per cgmp standards. Each bag is trackable with unique lot numbers, further ensuring dependable quality control measures. Additional features of our Collect-A-Cord kit include: Unique identification bar codes for each delivery Heparin free Individual instruction packets for both the parents and the delivery team Clear and concise instructions for packing the cord blood and cord tissue sample for shipment back to the CorCell s lab 24/7/365 CorCell phone support for both parents and delivery team Denser foam for transport protection Less packaging, which reduces our carbon footprint Temperature monitoring

14 CORCELL S MISSION CorCell Companies, Inc., a Cord Blood America company, aims to combat life-threatening illness. Our goal is to become the world s most respected stem cell company. CorCell will achieve its mission by educating expectant parents, families, and healthcare providers about the life-saving ability of umbilical cord blood stem cells, the future therapies of cord tissue stem cells and the importance of private and public cord blood preservation. We will protect families whose stem cells we store by providing world class support to them and their medical professionals. Always-here customer service. We are here for any question you or your delivery team have 24/7/365. Our customer care representatives are available to help guide you through the easy enrollment process. We guarantee your satisfaction, Call us at CORD (2673) $50,000 Quality Service Guarantee. If your child s cryopreserved cord blood and/or cord tissue stem cells are used for a stem cell transplant and fail to engraft, CorCell will pay the client $50,000 to defray the cost of procurement of an alternative stem cell source if medically indicated.* CORCELL S MISSION Your Baby. Your Price. We believe that every family should have access to affordable stem cell banking. Working with a set of predetermined payment plans makes that difficult, which is why we let you choose your own price per month to fit your budget, not ours. True affordability. No hidden costs. Our enrollment fee includes testing, processing and even the expense of a private courier. Because this service is so important we offer flexible payment options. You can select the best payment plan to meet your budget. Please ask us about our discount programs. You may qualify for one or more discounts! * Subject to certain restrictions. Please visit for more information.

15 COLLECTING CORD BLOOD AND TISSUE IS EASY 1) Complete and submit the forms on our website at Download the forms and return them by fax, or standard mail. 1) Fax to: (888) ) Scan and to: 3) Mail to: CorCell Companies, Inc Helm Drive Las Vegas, NV That s it! Once we receive your enrollment forms we will ship your Collect-A-Cord kit. Please call us at (888) (CORD) if you have any questions or need assistance with completing your enrollment forms. Tell Your Doctor About Your Decision Your doctor should know in advance that you ll be collecting your baby s cord blood. CorCell will provide your doctor and hospital with instructions. If your doctor has any questions about CorCell or the procedure itself, he or she can call us directly on our toll-free number. We re available 24/7/365. Have Your CorCell Collect-A-Cord Kit On Hand Once you ve enrolled with CorCell, we will send your Collect-A-Cord kit to bring to the hospital with you when you are ready to deliver. The kit contains everything necessary, including the telephone number of the courier who will come to your hospital room to pick up and transport directly to our laboratory. COLLECTING CORD BLOOD IT IS VERY IMPORTANT TO KEEP THE CORCELL COLLECT-A-CORD KIT AT ROOM TEMPERATURE. PLEASE DO NOT STORE IT IN YOUR CAR. Bring Your Collect-A-Cord Kit to the Hospital When You Deliver Make sure to bring your CorCell Collect-A-Cord kit with you when you go to the hospital to deliver your baby. It s a good idea to keep it right alongside any overnight bag you may have already packed. Once the blood is collected, call our special 24-hour toll-free number (included in your Collect-A-Cord kit) and we will dispatch a courier right away. And that s it! Final thought: If you decide not to store your baby s cord blood with CorCell, please consider donating this precious gift of life to a public bank. Donations can be made at no cost to you.

16 2014 CorCell Companies, Inc., a Cord Blood America company

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