Biomedical Research and Public Health Summer School 1 st Annual CSISP Summer School 2011 June 27/ August 12

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1 Biomedical Research and Public Health Summer School 1 st Annual CSISP Summer School 2011 June 27/ August 12

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3 CSISP Summer School The is addressed to graduate students, professionals and practitioners of biomedical research, public health and other biological and health sciences. It is intended as an overview of diverse fields of research bearing on Public Health, with a strong hands-on component and direct experience in a Public Health research center. The School will consist of 7 independent 1-weeklong modules of hours that may be taken individually and will include theoretical lectures, research seminars, and practical sessions. The Summer School will take place at the Center for Public Health Research (CSISP) of the Valencian Health Department and will be taught by CSISP researchers and by invited professors from leading international institutions. The official language will be english. 3

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5 Center for Public Health Research The CSISP, Centro Superior de Investigación en Salud Pública (Center for Public Health Research) is a public organisation affiliated with the Valencian Regional Government, with its own legal status, created under the Valencian Public Health Law. It is responsible for implementing the Regional Health Department s policy regarding research in public health; we are a public institution that works very closely with the Direction of Public Health of the Government of Valencia (Generalitat Valenciana). The CSISP aims at developing research-oriented scientific support for the public health policy community, and the Public Health Law created the Center to coordinate all the research in this field that is carried out in Valencia. Specifically, the CSISP is governed by regulations contained in Decree 120/2008, of September 5 th, which approved the statutes of the Centre for Public Health Research. Thus, CSISP represents the effort of the Generalitat Valenciana for the support of policy research in public health, formulated to develop applied research, to gain new knowledge and tools to increase the level of the population s health. The purpose of the CSISP is to develop and coordinate scientific activity proposed by the Direction of of Public Health as a core instrument in its research policy, whilst at the same time providing an environment that facilitates research activity for different external agents whose goals are in alignment with the strategic objectives of the centre. The research developed by the CSISP is multidisciplinary in nature requiring contributions from professionals in the field of public health, health workers and scientists from research centres and universities with the ultimate aim of conducting translational research leading to results that can be applied to health care as well as Public Health activities. The CSISP has different areas of interest in Public Health: Environmental Health, Cancer and Public Health, Vaccines Research, Genomics and Health, Health Inequalities, Rare Diseases, Food Safety, Health Services and Global Health. CSISP s mission is to generate new knowledge through excellence in research and its application in the field of Public Health, to develop this close coordination and to apply research focused on the health needs of citizens. 5

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7 Summer faculty Miriam Barlow, PhD (University of Rochester, New Cork, USA). Assistant Professor, School of Natural Sciences, University of California Merced. Evolution and spread of antibiotic resistance; molecular evolution and population genetics of bacterial pathogens; developing new tools for pathogen diagnostics. Ferran Ballester, MD, MPH (University of Valencia, Spain). PhD (University of Alicante, Spain). Senior Scientist, Coordinator of the Department of Enviroment and Health, Centro Superior de Investigación en Salud Pública (CSISP), Valencia, Spain; Professor of Public Health, University of Valencia, Spain. Environmental epidemiology and statistics. University of California Merced; Quantitative and Systems Biology Graduate Program; Faculty member, UC Merced Stem Cell Consortium. Hematopoietic stem cell biology; T lymphocyte development; bone marrow transplantation; HIV/AIDS. Fernando González-Candelas, PhD (University of Valencia, Spain). Professor of Genetics, University of Valencia (Instituto Cavanilles de Biodiversidad y Biología Evolutiva) and Senior Scientist Centro Superior de Investigación en Salud Pública (CSISP), Valencia, Spain. Evolutionary biology; molecular epidemiology; evolution of viruses and bacteria; bioinformatics; molecular evolution; conservation genetics; population genetics. M. Pilar Francino, PhD (University of Rochester, New York, USA). Senior Scientist, Department of Genomics and Health, Centro Superior de Investigación en Salud Pública (CSISP), Valencia, Spain and Adjunct Assistant Professor, School of Biological Sciences, University of California Merced. Metagenomics of the human gastrointestinal microbiota; evolutionary population genetics and genomics; evolution of bacterial pathogens. Manuel Franco, MD (Universidad Complutense, Madrid, Spain), PhD (Johns Hopkins Bloomberg School of Public Health, Baltimore, USA). Scientist at the Centro Nacional de Investigación Cardiovascular, Madrid, Spain; Adjunct Assistant Professor at the Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, USA. Cardiovascular disease epidemiology; cardiovascular disease prevention; epidemiological methods; social epidemiology; neighborhood health effects. Marcos E. García-Ojeda, PhD (Stanford University, USA). Assistant Professor, School of Natural Sciences, Carmen Martos, MD (University of Granada, Spain), PhD (University of Zaragoza, Spain).Senior Scientist at the Department of Rare Disease Research Area, Centro Superior de Investigación en Salud Pública (CSISP), Valencia, Spain; Professor at the University of Valencia, Spain. Rare disease epidemiology; health inequalities; cancer epidemiology. Óscar Zurriaga, MD, MPH, PhD (University of Valencia, Spain) Senior Scientist at the Health Inequalities Research Area, Centro Superior de Investigación en Salud Pública (CSISP), Valencia, Spain; Epidemiological Surveys and Health Statistics Unit. Department of Epidemiolgy. Dirección General de Salud Pública, Valencia, Spain. Epidemiology and temporal and spatial analysis methods in small areas; social determinants of health. Vicent Yusà, PhD (University of Valencia).Senior Scientist and Coordinator of the Food Safety Research Area (CSISP) and Associate Professor, Department of Analytical Chemistry (University of Valencia). Food safety, environmental contaminants, risk analysis. 7

8 Invited professors Juan José Abellán, PhD (University of Valencia, Spain). Senior Scientist, Department of Genomics and Health, Centro Superior de Investigación en Salud Pública (CSISP), Valencia, Spain. Biostatistics, Bioinformatics. Lucía Artazcoz, MD (Universidad de Navarra, Spain), MPH (Institut de Salut Pública de Catalunya, Spain), PhD (Universitat Pompeu Fabra, Spain). Agència de Salut Pública de Barcelona, Spain. Assistant Professor Johns Hopkins Bloomberg School of Public Health, Baltimore, USA. Health inequialities. Carmen Barona, MD, MPH, PhD (University of Valencia, Spain). Scientist at the Health Inequalities Research Area Centro Superior de Investigación en Salud Pública (CSISP), Valencia, Spain; Perinatal Health Unit, Department of Mother and Child Health, Dirección General de Salud Pública, Valencia, Spain. Reproductive health. Francisco Bolumar, MD, MPH (London School of Hygiene & Tropical Medicine). PhD (University of Seville). Professor (Catedrático) of Public Health at the Departamento de Ciencias Sanitarias y Medicosociales. Universidad de Alcalá. Madrid, Spain. Visiting Professor, London School of Hygiene & Tropical Medicine. Reproductive and perinatal health. Migration and health. Ana Mª García, PhD (University of Valencia, Spain), PhD (University of London, England). Lecturer at the University of Valencia and Contracted Researcher at the Trade Union Institute of Work, Environment and Health (Instituto Sindical de Trabajo, Ambiente y Salud, ISTAS). Epidemiology and Occupational Health. Carmen Iñiguez, PhD (University of Valencia, Spain). Scientist of Environment and Health area, Centro Superior de Investigación en Salud Pública (CSISP), Valencia, Spain. Statistics and environmental epidemiology. M José López-Espinosa, PhD (University of Granada, Spain). Lecturer at the London School of Hygiene and Tropical Medicine. Environmental Epidemiology. Alejandro Mira, PhD (University of Alicante, Spain). Senior Scientist, Department of Genomics and Health, Centro Superior de Investigación en Salud Pública (CSISP), Valencia, Spain. Oral microbiome. Olga Pardo, PhD (University of Valencia). Scientist of the Food Safety Research Area (CSISP) and Associate Professor, Department of Analytical Chemistry (University of Valencia). Food safety, environmental contaminants, risk analysis. Vicenta Escribá-Agüir, MD (University of Valencia, Spain), PhD (University of Alicante, Spain). Scientist at the Health Inequalities Research Area, Centro Superior de Investigación en Salud Pública (CSISP), Valencia, Spain; Department of Health Promotion. Dirección General de Salud Pública, Valencia, Spain. Work-related gender inequalities in health and violence against women. 8

9 Teaching assistants Pedro Belda, PhD Student (University Miguel Hernández, Alicante, Spain). Department of Genomics and Health, Centro Superior de Investigación en Salud Pública (CSISP), Valencia, Spain Raúl Cabrera, PhD Student (University Miguel Hernández, Alicante, Spain). Department of Genomics and Health, Centro Superior de Investigación en Salud Pública (CSISP), Valencia, Spain. Giuseppe D auria, PhD (University of Mesina, Italy). Department of Genomics and Health, Centro Superior de Investigación en Salud Pública (CSISP), Valencia, Spain. Marc García, PhD Student (Universitat Pompeu Fabra, Barcelona). Department of Genomics and Health, Centro Superior de Investigación en Salud Pública (CSISP), Valencia, Spain. Nuria Jiménez, PhD (University of Valencia, Spain). Department of Genomics and Health, Centro Superior de Investigación en Salud Pública (CSISP), Valencia, Spain. Pablo Marín, European Bioinformatics Institute, Cambridge, England. Llúcia Martínez, Master en Tecnologías aplicadas al sector agrario y agroalimentario (Univ. Pierre et Marie Curie, Paris, Francia). Department of Genomics and Health, Centro Superior de Investigación en Salud Pública (CSISP), Valencia, Spain. Francesc Peris, Biodiversity and Evolutive biology Master (University of Valencia, Spain). Department of Genomics and Health, Centro Superior de Investigación en Salud Pública (CSISP), Valencia, Spain. Miguel Pignatelli, PhDEuropean Bioinformatics Institute, Cambridge, England. Yvonne Vallés, PhD (University of Berkeley, California). Department of Genomics and Health, Centro Superior de Investigación en Salud Pública (CSISP), Valencia, Spain. 9

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11 Summer modules 2011 This year s Summer School will be divided into 7 Modules over 7 weeks. The Modules will themselves be divided into 2 Tracks (weeks 1 to 4 and weeks 4 to 7) Module 1 will be repeated in weeks 1 and 4. Course participants may: 1) Complete all modules over 7 weeks, 2) Complete either Track 1 or Track 2, or 3) Complete one or more individually selected modules. Track 1 Epidemiology for Public Health Track 2 Genetics and genomics for Public Health Week 1. June 27-July 1 Module 1- Epidemiological methods and study design Organizer: Carmen Martos (CSISP) Week 4. July 18-July 22 Module 1- Epidemiological methods and study design Organizer: Carmen Martos (CSISP) Week 2. July 4-July 8 Module 2 - HIV/AIDS and Public Health Organizer: Marcos E. García-Ojeda (UC Merced) Week 3. July 11-July 15 Module 3 - Social Epidemiology Organizers: Manuel Franco (CNIC) and Oscar Zurriaga (CSISP) Week 4. July 18-July 22 Module 4 - Environmental health and food safety Organizers: Ferran Ballester and Vicent Yusà (CSISP) Week 5. July 25-July 29 Module 5 - Molecular epidemiology Organizer: Fernando González Candelas (CSISP) Week 6. August 1- August 5 Module 6 - Human microbiome and health Organizer: M. Pilar Francino (CSISP) Week 7. August 8- August 12 Module 7 - Antibiotics and Public Health Organizer: Miriam Barlow (UC Merced) 11

12 Module 1/ Epidemiological methods and study design Module 2/ HIV/AIDS and Public Health Organizer: Carmen Martos (CSISP) The goal of this course is to provide a background in designs and methods to describe disease occurrence and risk factor associations. The course emphasis is on how to undertake epidemiological research, including study planning, data analyses, and interpretation of results. The course will particularly address the quantitative issues of epidemiology and applications of some statistical techniques. We will discuss how to avoid bias, control confounding effects and detect effect modification at study design and data analysis stages. Lectures will be completed by case studies. Appropriate statistical methods will be integrated with the main epidemiological content, and practical sessions will make use of the R commander computer software Organizer: Marcos E. García-Ojeda (UC Merced) The spread of HIV represents the biggest failure in the history of public health, threatening to undermine hard-won development gains in many countries. In some African countries between half and two thirds of all people 15 years old and older are going to die of AIDS. Since the time that HIV was first identified, there have been significant gains in knowledge about how to prevent and treat HIV infection and mitigate the worst social and economic impacts for individuals, families, and communities. This module examines the epidemic that was first defined in the USA and which continues to spread exponentially in many parts of the world. The module will be divided into three parts: 1) what is known about the natural history of the disease, its transmission, and the spread of the epidemic; 2) what is needed to control the epidemic and to care for those infected; 3) what are the impacts, politics, ethics, policy, and human aspects of the disease. 12

13 Module 3/ Social Epidemiology Module 4/ Environmental health and food safety Organizers: Manuel Franco (CNIC) and Oscar Zurriaga (CSISP) This course provides students with a systematic and selective overview of conceptual approaches and research findings related to the impact of social context on the health of various populations. The course is divided into 5 sessions; each highlights a different area of research. Lectures and large-group discussions will be in English, however small-group discussions will take place in both English and Spanish. The topics to be addressed include: - The concepts, theory and history of social epidemiology - Social class, inequality and health - Neighborhood conditions and health - Gender, social class and health - Migration and health: the case of reproductive health Emphasis will placed on extending the causal chain thought to be associated with patterns of acute and chronic disease to include upstream factors related to social context. This includes discussion of methods related to the study of social factors across multiple levels; however, this is not intended to be a methods course. The course will be taught as a seminar with brief lectures followed by small-group discussion of assigned readings. Organizers: Ferran Ballester and Vicent Yusà (CSISP) This course will provide an overview of the needs of public health professionals to critically interpret the environmental health and food safety literature and it will provide attendees with the fundamentals and practical experience needed to start scientific work in this area. The goal of the course will be developing knowledge and competences on the field of environmental health and food safety and increasing awareness on risk assessment in these fields. It will provide an orientation to environmental health and food safety as basic tools for evaluating health risks derived from environmental or occupational exposures and diet as well as for evaluating risk analysis derivedfrom the presence of different contaminants in environment or foodstuffs. The course will explore the different tools to evaluate risk analysis concerning public health problems. During the course, the main environmental health topics will be discussed, i.e. air pollution, climate change, occupational exposures, and food and water contamination. The priority residues and contaminants such as metals, veterinary drugs, persistent compounds and biotic contaminants will be studied from public health, occurrence and analytical perspectives. The program includes practical training and combines several seminars and class discussions. 13

14 Module 5/ Molecular Epidemiology Module 6/ Human Microbiome and Health Organizer: Fernando González Candelas (CSISP) This course will provide an introduction to the concepts and methods of molecular population genetics and evolution applied to specific problems in the short, medium and long-term evolution of infectious microorganisms. Molecular epidemiology is an emerging discipline in the interface between molecular biology, population and evolutionary genetics, and traditional epidemiology interested in providing a perspective on population and epidemic processes from the perspective of the infectious organism. From the origin of new pathogens to the sources of outbreaks or more detailed surveillance, there is an increasing number of uses for molecular epidemiology approaches which practicing epidemiologists should become familiar with. This course provides an excellent opportunity for breaking the initial barriers. Organizer: M. Pilar Francino (CSISP) The course is addressed to graduate students, professionals and practitioners of biology, biomedical research and the health sciences. Some background in molecular biology will be advantageous, though it is not required. The course will consist of theoretical lectures and seminars in the morning and 2 afternoon practicals in molecular biology techniques (day 2) and bioinformatics and biostatistics analysis (day 3). Attendants are welcome to bring their own data. Human microbiome and its relationship to health; molecular biology, genomics and metagenomics; 16/18S rrna and metagenomic approaches to biodiversity analysis; metagenomic and metatranscriptomic analyses of microbial community function; cell population analysis by flux cytometry; sequencing technology; Wet lab on DNA extraction and PCR; Bioinformatics for sequence analyses; Statistics for microbiome analysis and comparison; Bioinformatics and Biostatistics practical (hands on); microbiome, obesity and gastrointestinal disease; microbiome development, atopy and inflammatory/autoimmune diseases. - Research talk on Irritable Bowel Syndrome - Research talk on Clostridium infections after antibiotic treatment. - Research talk on oral microbiome in health and disease - Research talk on skin microbiome in health and disease. 14

15 Module 7/ Antibiotics and Public Health Organizer: Miriam Barlow (UC Merced). There are many controversial issues surrounding the prescription of antibiotics, the delivery of the best possible health care, and the occurrence of antibiotic resistance. The therapies that are in the best interest of the doctor, the patient, and society as a whole are usually different and in conflict with each other. We will examine these issues as well as the widespread evolution of antibiotic resistance, and what can be done to stop it. 15

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17 Application Application procedures All graduate students, professionals and practitioners of biomedical research, public health and other biological and health sciences that are interested in applying for summer course/s must download and complete the course selection form ( Please, be sure to read carefully all sections and instructions for completing the course/s form/s and after completing them with all the information required, submit the application preferably by to: CSISP SUMMER SCHOOL - Centro Superior de Investigación en Salud Pública. Avda. Catalunya, nº , Valencia, Spain summerschool_csisp@gva.es Phone: Fax: Resume or CV With the course/s form/s, submit an up-to-date copy of your resume or Curriculum Vitae to the address indicated in the preceding paragraph. Application Fee A non refundable application fee of 50 is required. You may pay on line by credit card ( or by bank transfer to the next account number: Nº: IBAN: ES SWIFT: CAIXESBBXXX Application deadline The deadline for the application is May 31, After this date, for late applications, in case of being interested in applying for one or several courses, contact with the Summer School department to study this special situation (summerschool_csisp@gva.es). Fee and tuition A late fee of 50 will be applied to all applications after May 31, Applications received after this date will be considered on a space-available basis. Tuition rate for each module is 500. In case of registering for one track, this is for 4 modules, tuition rate will be 20% reduced to In case of registering for all courses, this is, for the entire curriculum of the, tuition rate will be 40% reduced to Students are responsible for all other expenses associated with summer courses (transportation, health insurance, housing, food ). Payment in full is required by the first day of class. CSISP Fellowships in collaboration with some sponsors gives a number of fellowships which offer some help with the travel fee and the accommodation fee. To apply for a fellowship you have to include with your application a letter explaining the reasons you need help. Awards are made on the basis of academic merit. If you are interesting in applying for this fellowships download and complete the fellowship form. ( Applications for all fellowships should be received by 15th May. Cancellation and refund policies Admitted students who draw back from summer courses before June 30, 2011 will be repaid 100 percent of their tuition fee. Withdrawal after those dates corresponds to a prorated schedule. 17

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19 General Information Housing Lluis Vives Residence Hall Av. Blasco Ibañez, Valencia Located in the centre of the Blasco Ibáñez campus close to CSISP. It provides 167 students with accommodation and there are rooms for 26 lecturers. The hall has a canteen, a bar, a library, a gym, video, music, and computer rooms, and an Internet connection in each room. Phone: Info and booking:cllvives@uv.es - Damià Bonet Residence Hall C/ Serpis, Valencia The Damià Bonet Residence Hall has single and double studios and suite apartments with bathroom, kitchen, living-dinning room with TV, terrace and double bedroom. The studios and the apartments fully equipped have air-conditioning, telephone and computer connection with Internet access. Phone: Info and booking: damiabonet@resa.es - Meals CSISP Lunch Room Av. Cataluña, Valencia The CSISP lunch room is situated on the second floor. Equipped with refrigerator, dishwasher, oven and microwave where you can heat your food. The dining room is 30 seats and has an area for relaxation. Universidad Politécnica de Valencia Camino de Vera s/n Valencia Open 07:30 to 21:00 h. The cafeteria-restaurant offers daily menus for 4 euros and is located just 5 minutes walking from CSISP. Phone lvella@upvnet.upv.es Reuniver University Residence C/Jose Maria de Haro, Valencia Reuniver, is located close to CSISP and the Campus de los Naranjos of the University of Valencia. The residence has 60 rooms on three floors in a recently constructed building. Phone: Info and booking: info@reunivervalencia.com These are different options for your stay in Valencia. If you are interested in reservations in any of them, contact us to inform you about the availability and prices: summerschool_csisp@gva.es 19

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21 Valencia City A wide range of cultural, fun and festive offers keeps the city of Valencia in a constant state of animation. Valencia is now a worldwide landmark for its state of the art architecture, science, arts and sport. Various exhibitions continually display the richest museum funds on the cultural scene. History, ethnology, ceramics, paintings, sculptures, biodiversity and science are some of the many offers available. Valencia is a city with over 2000 years of history, which it displays through various popular celebrations both of a religious and a non-religious nature. Creativity, gunpowder, music and fire, together with the kindness of the people, make Valencia that unique corner of the world that every traveller dreams of finding. Getting around - By metro: it is really easy, download the metro map or visit where you can look up the stops that will be most convenient for you, plan your journey in real time or check and download the timetable. If you are travelling on line 4 of the metro, you stop off at U.Politécnica or V.Zaragozá, the stops closest to CSISP. - By bus: Valencia has a city and suburban bus network that reaches every corner of the city. Bus services start at 4 AM on some of the lines, and end at 11 PM. Then follows the night bus service, which ends at 2 AM, except for Fridays, Saturdays and the nights before public holidays, when it continues until 3:30 AM. As well as regular day and night services, in summer and at other specific times such as during the European Grand Prix or major festivals, additional special bus services are put on. Services to the suburbs are provi- ded by a consortium of transport companies grouped together under the name of Metrobús. These services link the city with surrounding towns and villages. More info: EMT (Empresa Municipal de Transportes de Valencia) Leisure There are many leisure zones distributed throughout the city: - Barrio del Carmen (a melting pot of different cultures in the very heart of the city). - Cánovas, Juan Llorens, Aragón and Blasco Ibáñez (traditional nightlife zones) - City of Arts and Sciences (the freshest, most avantguard proposals). - Marina Real Juan Carlos I (a cosmopolitan atmosphere in a luxury setting) - Some tips for enjoying Valencian nightlife: Remember that the action starts around midnight and carries on until dawn. Valencia has a variety of concert halls, auditoriums and smaller venues where all kinds of musical styles can be enjoyed throughout the year. From large concert halls to intimate jazz clubs, from classical to flamenco. During the month of July a series of outdoor concerts with national and international artists are celebrated in the park Jardines de Viveros. Spanish lessons If you are interested, we can offer Spanish classes taught on site at CSISP. You can contact us for information on schedules and prices at summerschool_csisp@gva.es 21

22 For more Information Centro Superior de Investigación en Salud Pública, CSISP Conselleria de Sanitat. Generalitat Valenciana Avda. Catalunya, Valencia Spain Tel.: Fax: Europe, Spain, Valencia