Case Report of Renal Cell Carcinoma Diagnosed in Voided Urine Confirmed by CD10 Immunocytochemistry

Size: px
Start display at page:

Download "Case Report of Renal Cell Carcinoma Diagnosed in Voided Urine Confirmed by CD10 Immunocytochemistry"

Transcription

1 Novel Insights from Clinical Practice DOI: / Received: January 6, 2011 Accepted: February 21, 2011 Published online: July 22, 2011 Case Report of Renal Cell Carcinoma Diagnosed in Voided Urine Confirmed by CD10 Immunocytochemistry Sanjivani B. Dubal a Saleem Pathuthara a Dulhan Ajit a Santosh Menon b Shubhada V. Kane a Departments of a Cytopathology and b Pathology, Tata Memorial Hospital, Mumbai, India E s t a b l i s h e d Fa c t s Not every carcinoma detected in urine cytology is necessarily a transitional cell carcinoma. Renal cell carcinoma can be suspected by urine cytology based on cytomorphology and can be confirmed later in a clinicoradiological context. However, a prospective diagnosis of renal cell carcinoma in urine cytology is rare. Hence this case report. The underdiagnosis of renal cell carcinoma in urine is probably due to minimal cytological atypia and its close resemblance to degenerative urothelial cells. In addition, obscuring hemorrhage and inflammation can lead to screening and interpretative error (false negative). N ove l I n s i g h t s A specific constellation of cytomorphologic features like papillary clusters with bland nuclear features and vacuolated cytoplasm in conjunction with the appropriate clinical setting favors the diagnosis of renal cell carcinoma in urine cytology. Use of immunocytochemistry on smears (destained/restained) with CD10 antibody can confirm the diagnosis. Accurate diagnosis of renal cell carcinoma on urine cytologic examination can avoid further investigations and thereby minimize the cost. Key Words Renal cell carcinoma Urine Cytology Immunocytochemistry CD10 Abstract Background: Preoperative diagnosis of renal cell carcinoma (RCC) by exfoliative urine cytology is difficult, as infiltration of RCC into the pelvicalyceal system is uncommon. The ex- foliation of RCC cells in urine is a rare phenomenon and when it does occur, it is likely to be missed. Cytologic examination of the urine coupled with ancillary immunocytochemistry can clinch the diagnosis leading to appropriate clinical management. Case: A 50-year-old man presented with complaints of hematuria and abdominal pain of 6 months duration. Ultrasonographic examination of the abdomen and pelvis showed a well-defined mass lesion in the upper pole of the left kidney, suggestive of neoplastic etiol- Fax karger@karger.ch S. Karger AG, Basel /11/ $38.00/0 Accessible online at: Correspondence to: Mr. Saleem Pathuthara Department of Cytopathology, Tata Memorial Hospital Parel, Mumbai, Maharashtra (India) Tel , ext gmail.com

2 ogy. In the given clinical context of renal mass, urine cytology was suggestive of RCC and biopsy confirmation was suggested. One cytology smear subjected to immunocytochemistry with anti-cd10 antibody which showed strong diffuse cytoplasmic positivity in these cells confirmed the diagnosis of RCC. Subsequently, fine needle aspiration cytology of the kidney mass was reported as RCC. Conclusions: RCC has distinct cytologic features that facilitate a diagnosis in urine in an appropriate clinical and radiological context. Their recognition in the urine smear is important to avoid costly and invasive modalities like image-guided needle biopsy. Copyright 2011 S. Karger AG, Basel Renal cell carcinoma (RCC) is the most common form of malignancy arising in the adult kidney and accounts for 90 95% of all kidney cancers. Cytologic examination of voided urine is a simple, noninvasive, cost-effective diagnostic modality used to detect any abnormal cells that exfoliate from the urinary tract into the bladder. Traditionally, transitional cell carcinoma (TCC) of the lower urinary tract, i.e. the bladder and ureter, is diagnosed by urine cytology. Cytological findings of papillary RCC obtained from fine needle aspiration or imprint smears have been reported previously [1 4]. To our knowledge, only one case report on papillary RCC diagnosed in voided urine in a patient with renal calculus [5] has been published. devoogt et al. [6] have elaborately described the differential cytomorphological features of RCC, histiocytes and degenerating urothelial cells in urine smear stained by May- Grünwald-Giemsa stain way back in We report a (rare) case of RCC detected by urine cytology in a patient presenting with renal mass and hematuria and confirmed by immunocytochemistry (ICC) of the destained smears. C a s e R e p o r t Fig. 1. CT scan showing a well-defined solid lesion in the upper pole of the left kidney, measuring 32 mm in craniocaudal, 30 mm in transverse and 34 mm in anteroposterior dimensions. A 50-year-old man with complaints of hematuria and abdominal pain attended our urology outpatient department in On a computerized tomography scan of the abdomen and pelvis, a well-defined solid lesion was seen in the upper pole of the left kidney, measuring about 32 mm in craniocaudal, 30 mm in transverse and 34 mm in anteroposterior dimensions ( fig. 1 ). No calcification or calculus was identified. The urinary bladder, seminal vesicles and prostate did not show any abnormality. Minimal ascitis and bilateral pleural effusions were present, which was not tapped. Renal function tests showed elevated levels of serum urea (179 units/ml) and serum uric acid (13.5 mg/dl), whereas serum creatinine was within the normal range (3.9 mg/dl). Urine cytology examination was also performed for the work-up in view of hematuria. About 20 ml of a random sample of urine was collected and submitted to cytology. Grossly, the sample was deep red in color due to hemorrhage. Centrifugation was done at 2,000 rpm for 10 min. The supernatant was discarded and the sediment was picked up with the help of a cotton-tipped applicator stick and smears were prepared by rolling the swab stick on albuminized glass slides. The smears were fixed in 100% methanol and stained by the standard Papanicoloau method. Cytologic Findings The smears were cellular and showed a dual population of cells comprising benign urothelial cells and large atypical cells. The atypical epithelial cells occurred singly and in clusters with papillary architecture. These cells showed characteristic abundant clear to foamy cytoplasm and well-defined cytoplasmic borders as well as a slightly high nuclear cytoplasmic ratio ( fig. 2, 3 ), and the nuclei were round and eccentrically placed and showed vesicular chromatin, a thick nuclear membrane with single or multiple small nucleoli. In addition to atypical cells, smears showed singly occurring benign urothelial cells in the background. These cells showed abundant dense cytoplasm and central vesicular small nuclei. The chromatin was finely granular with a smooth nuclear membrane and inconspicuous nucleoli. The N/C ratio was low. These urothelial cells did not show any cytological or architectural atypia. The cytomorphology of abnormal cells led to suspicion of RCC which matched with the clinicoradiological findings. In the given clinical context of the renal mass and no radiological abnormality in the bladder, urine cytology was suggestive of conventional RCC, and biopsy conformation was advised. Im m u n o c y t o c h e m i s t r y One of the cytology smears was destained and subjected to ICC with anti-cd10 (common acute lymphocytic leukemia anti- Renal Cell Carcinoma Diagnosed in Voided Urine 373

3 2 3 Fig. 2, 3. Voided urine. Cluster of RCC cells with abundant foamy cytoplasm, vesicular eccentric nuclei, fine powdery chromatin and nucleoli. Papanicoloau stain.! 400. in Tris buffer. Primary antibody CD10 (Biocare, dilution 1: 40) was applied for 1 h and washed in Tris buffer. Polymer technology was used as secondary detection system, and after polymerizing for 30 min, 3-3 -diaminobenzidine trichloroacetic acid was applied as chromogen, counterstained with hematoxylin for 5 min and then mounted in DPX. The atypical cells showed strong diffuse cytoplasmic positivity with CD10, which confirmed the diagnosis of RCC ( fig. 4 ). Final Diagnosis Following urine cytology, an ultrasound-guided aspiration from the renal mass was performed. The aspirate was cellular and showed many clusters of atypical cells arranged in sheets and papillary structures. The cells showed central small round nuclei, fine granular chromatin, inconspicuous nucleoli and abundant foamy cytoplasm ( fig. 5, 6 ). These features were consistent with the diagnosis of conventional RCC. Fig. 4. Voided urine. Strong diffuse cytoplasmic immunoreactivity with CD10 antibody in the destained smear confirms the cytologic diagnosis. Treatment and Follow-Up The patient was advised with left radical nephrectomy and, according to his request, the same was planned to be performed at his native place. gen) antibody by using 3-3 -diaminobenzidine trichloroacetic acid as the chromogen. First, the cover slip was removed by immersing the slide in xylene overnight. Subsequently, the slide was kept in 95% ethanol for 1 h and destained in acid alcohol (1% HCl in 70% ethanol) for 30 s. After thorough washing in water, the excess water was blotted. The endogenous peroxidase activity was quenched using 3% H 2 O 2 in methanol for 10 min and washed in running tap water. Antigen retrieval was done by microwaving at low power (180 W for 2 min). After cooling, the smear was washed Discussion RCC represents 80 90% of all malignant tumors of the kidney and 2% of all cancers in adults [7]. It is most common in the late middle age, from the 5th to the 7th decade, and males are affected more often than females. Hematuria and dull abdominal pain are the main features of clinical presentation. 374 Dubal /Pathuthara /Ajit /Menon /Kane

4 5 6 Fig. 5, 6. Fine needle aspiration smears showing clusters of atypical cells with small round nuclei, finely granular chromatin, inconspicuous nucleoli and abundant foamy cytoplasm. Papanicoloau and Giemsa stain.! 400. Detection of tumor cells in the urine is not possible until the cells exfoliate into the urine in large numbers. Cancer cells that arise from the transitional epithelium lining the urinary tract exfoliate directly into the urine. The cells are carried to the bladder and voided in the urine. Thus, the cells of TCC arising from the pelvicalyceal system, ureter or urinary bladder can be detected easily on urine cytologic examination. On the other hand, intrarenal tumors, lying within the renal cortex [8], do not exfoliate cells into urinary passages until they have penetrated the wall of the structures (e.g. the renal pelvis) en mass. Most RCC clinically present with gross hematuria in a later stage. Thus, the scanty exfoliated tumor cells are easily missed on casual screening as they are masked due to hemorrhage. Thus, diagnosis of RCC on urine cytologic examination is uncommon. In addition, degenerative changes [9] in the epithelial cells in urine samples are very common due to the alkaline ph. Hence, at times, it is difficult to pick up the stray degenerating tumor cells and interpret them appropriately. As a result of all these factors, a high degree of sensitivity in detecting RCC in the urine is not expected. Therefore, a high index of suspicion is necessary in such a clinical setting, particularly in smears with hemorrhagic background. Differential diagnoses include reactive and degenerating urothelial cells, foamy macrophages, papillary TCC, as well as colonic adenocarcinoma. Reactive urothelial cells show enlarged nuclei, prominent nucleoli and abundant dense cytoplasm with a low N/C ratio. Degenerating urothelial cells show vacuolated cytoplasm with degenerative nuclear changes. However, these cells depict urothelial morphology. Chromatin and nuclear membrane abnormality associated with cancer cells is not evident. devoogt et al. [6] have highlighted the presence of central nuclei, finely vacuolated cytoplasm, a low N/C ratio and relatively large nucleoli in a monomorphic population of cells as characteristic features of RCC. In papillary TCC, papillary clusters of cells with variable sizes and shapes are seen [10]. Also, TCC cells show obvious nuclear enlargement, a high N/C ratio, nuclear hyperchromasia, irregular nuclear border and dense cytoplasm. On the other hand, papillary RCC will show abundant foamy cytoplasm, eccentric round nuclei with conspicuous nucleoli, a thick nuclear membrane and vesicular chromatin besides the papillary architecture. Foamy macrophages with intracytoplasmic hemosiderin and nuclear grooves in the tumor cells were not seen in the smears which are usually observed in the fine needle aspiration cytology of papillary RCC [11]. Foamy macrophages are a close mimic of RCC cells. The pale reniform nuclei with cytoplasmic phagocytosis help in their recognition and differentiation from RCC cells. In colonic adenocarcinoma, tubular or elongated clusters of large cells with elongated hyperchromatic and pseudostratified nuclei, coarse chromatin and vacuolated or clear cytoplasms are noted [10]. Primary kidney tumors are of varied histological types. RCC, particularly the clear cell type, is the most common primary tumor. Going through the literature, there is only one case report [5] having detected RCC in Renal Cell Carcinoma Diagnosed in Voided Urine 375

5 voided urine cytology; however, we came across one article which reported collecting duct carcinoma in urine cytology [12]. In this case, urine cytology showed cellular abnormalities that were not typical of TCC, yet were suspicious of neoplastic etiology. It is difficult to assess the sensitivity and specificity of urine cytologic examination in recognizing tumors of the upper urinary tract, particularly RCC due to small number. The role of ICC in confirming the diagnosis of RCC has been well worked out. The use of monoclonal antibodies to RCC and CD10 in differentiating clear cell carcinoma of the kidney from chromophobe cell carcinoma, TCC or oncocytoma has been documented by Yang et al. [13] and Avery et al. [14]. TCC is the commonest histological type of tumor of the urinary tract, usually arising from the bladder, and less commonly, from the pelvis and ureters. These tumors can be easily detected by urine cytology, as the cells are readily exfoliated into urine. The tumors of the non- TCC type include mainly RCC which seldom exfoliates cells into urine, to be detected by urine cytology. Therefore, correlation with imaging findings is essential for the proper interpretation of atypical cells detected in the urine which do not look like TCC cells. The possibility of RCC should be considered as one of the differentials in such cases. If in doubt as to whether it is RCC or TCC or degenerating urothelial cells, it is recommended to do an ICC on smears using CD10, CK7, EMA PG3 and HMWCK markers. Urine cytology is a simple, cheap, cost-effective, noninvasive investigation. It may be helpful to identify the origin of cancer cells with reasonable certainty and thus contribute to the final diagnosis. However, it is important to be familiar with the cytological picture of RCC so as to avoid screening and interpretative errors and increase the diagnostic utility in urine cytology. This case highlights the scope of primary diagnosis of RCC in urine cytology. Preoperative diagnosis of RCC in urine helps in appropriate treatment planning, including surgery and targeted therapy. References 1 Granter SR, Perez-Atayde AR, Rensahaw AA: Cytologic analysis of papillary renal cell carcinoma. Cancer Cytopathol 1999; 94: Flint A, Cookingham C: Cytologic diagnosis of the papillary variant of renal cell carcinoma. Acta Cytol 1997; 31: Dekmezian R, Sneige N, Shabb N: Papillary renal cell carcinoma: fine needle aspiration of 15 cases. Diagn Cytopathol 1991; 7: Renshaw AA, Lee KR, Madge R, Granter SR: Accuracy of fine needle aspiration in distinguishing subtypes of renal cell carcinoma. Acta Cytol 1997; 41: Kawakami H, Hoshida Y, Hanai J: Voided urine cytology of papillary RCC and renal calculus. Acta Cytol 2001; 45: devoogt HJ, Rathert P, Beyer-Boon ME: Urinary Cytology: Phase Contrast Microscopy and Analysis of Stained Smears. Berlin, Springer, 1977, pp 39, Garnick, MB, Riche JP: Renal neoplasia in the kidney; in Brenner BM, Recher FC Jr (eds): The Kidney, ed 3. Philadelphia, Saunders, 1986, pp Foot NC, Papanicoloau GN, Holmquist ND, Seybolt JF: Exfoliative cytology of urinary sediments: a review of 2,829 cases. Cancer 1958; 11: Koss LG: Tumors of the urinary tract and prostate in urinary sediment; in Koss LG: Diagnostic Cytopathology and Its Histopathologic Bases, ed 4. Philadelphia, Lippincott, 1992, p Koss LG: Diagnostic Cytology and Its Histologic Bases, ed 4. Philadelphia, Lippincott, 1992, pp Granter SR, Perez-Atayde AR, Renshaw AA: Cytologic analysis of papillary renal cell carcinoma. Cancer Cytopathol 1999; 94: Fallick ML, et al: Collecting duct carcinoma presenting as upper tract lesion with abnormal urine cytology. Diagn Cytopathol 1997; 16: Yang B, Ali SZ, Rosenthal DL: CD10 facilitates the diagnosis of metastatic RCC from primary adrenal cortical neoplasm in adrenal fine-needle aspiration. Diagn Cytopathol 2002; 27: Avery AK, Beckstead J, Rensahaw AA, Coreless CL: Use of antibodies to RCC and CD10 in the differential diagnosis of renal neoplasm. Am J Surg Pathol 2000; 24: Dubal /Pathuthara /Ajit /Menon /Kane

Diagnostic Challenge. Department of Pathology,

Diagnostic Challenge. Department of Pathology, Cytology of Pleural Fluid as a Diagnostic Challenge Paavo Pääkkö,, MD, PhD Chief Physician and Head of the Department Department of Pathology, Oulu University Hospital,, Finland Oulu University Hospital

More information

Cytology : first alert of mesothelioma? Professor B. Weynand, UCL Yvoir, Belgium

Cytology : first alert of mesothelioma? Professor B. Weynand, UCL Yvoir, Belgium Cytology : first alert of mesothelioma? Professor B. Weynand, UCL Yvoir, Belgium Introduction 3 cavities with the same embryologic origin the mesoderme Pleura Exudates Pleura Peritoneum Pericardium 22%

More information

Cytopathology Case Presentation #8

Cytopathology Case Presentation #8 Cytopathology Case Presentation #8 Emily E. Volk, MD William Beaumont Hospital, Troy, MI Jonathan H. Hughes, MD Laboratory Medicine Consultants, Las Vegas, Nevada Clinical History 44 year old woman presents

More information

Carcinosarcoma of the Ovary

Carcinosarcoma of the Ovary Carcinosarcoma of the Ovary A Rare Finding Presented By: Kathryn Kiely Anisa I. Kanbour School of Cytotechnology of the University of Pittsburgh Medical Center Pittsburgh, PA Patient History 55 year old

More information

Something Old, Something New.

Something Old, Something New. Something Old, Something New. Michelle A. Fajardo, D.O. Loma Linda University Medical Center Clinical Presentation 6 year old boy, presented with hematuria Renal mass demonstrated by ultrasound & CT scan

More information

Gladwyn Leiman, MCCCh, FIAC, FRCPath Scott Anderson, MD

Gladwyn Leiman, MCCCh, FIAC, FRCPath Scott Anderson, MD Cytology Works shop #5 Gladwyn Leiman, MCCCh, FIAC, FRCPath Scott Anderson, MD Disclosur re information The speakers have no relationship that represents a possible conflict of interest with respect to

More information

Practical Effusion Cytology

Practical Effusion Cytology Practical Effusion Cytology A Community Pathologist s Approach to Immunocytochemistry in Body Fluid Cytology Emily E. Volk, MD William Beaumont Hospital Troy, MI College of American Pathologists 2004.

More information

Multiple Primary and Histology Site Specific Coding Rules KIDNEY. FLORIDA CANCER DATA SYSTEM MPH Kidney Site Specific Coding Rules

Multiple Primary and Histology Site Specific Coding Rules KIDNEY. FLORIDA CANCER DATA SYSTEM MPH Kidney Site Specific Coding Rules Multiple Primary and Histology Site Specific Coding Rules KIDNEY 1 Prerequisites 2 Completion of Multiple Primary and Histology General Coding Rules 3 There are many ways to view the Multiple l Primary/Histology

More information

Introduction. Case History

Introduction. Case History NAOSITE: Nagasaki University's Ac Title Author(s) A Case Report of Renal Cell Carcino Shimajiri, Shouhei; Shingaki, Yoshi Masaya; Tamamoto, Tooru; Toda, Taka Citation Acta Medica Nagasakiensia. 1992, 37

More information

Outline. Workup for metastatic breast cancer. Metastatic breast cancer

Outline. Workup for metastatic breast cancer. Metastatic breast cancer Metastatic breast cancer Immunostain Update: Diagnosis of metastatic breast carcinoma, emphasizing distinction from GYN primary 1/3 of breast cancer patients will show metastasis 1 st presentation or 20-30

More information

SEMESTER VI 3 RD YEAR PATHOLOGY KIDNEY TUMORS

SEMESTER VI 3 RD YEAR PATHOLOGY KIDNEY TUMORS SEMESTER VI 3 RD YEAR PATHOLOGY KIDNEY TUMORS LEARNING OBJECTIVES At the end of the lecture, students should be able to: Know the pathology of renal tumors. RENAL TUMORS RENAL PAPILLARY ADENOMA Common

More information

Cytology of Lymph Nodes

Cytology of Lymph Nodes Indications Cytology of Lymph Nodes Lymph node enlargement That was easy Mary Anna Thrall Don Meuten Indications Lymph node enlargement Suspect metastasis Normal sized lymph nodes are Normal Do NOT aspirate

More information

Renal Cell Carcinoma: Advances in Diagnosis B. Iványi, MD

Renal Cell Carcinoma: Advances in Diagnosis B. Iványi, MD Renal Cell Carcinoma: Advances in Diagnosis B. Iványi, MD Department of Pathology University of Szeged, Hungary ISUP Vancouver Classification of Renal Neoplasia Am J Surg Pathol 37:14691489, 2013 13 histologic

More information

Effusions: Mesothelioma and Metastatic Cancers

Effusions: Mesothelioma and Metastatic Cancers Effusions: Mesothelioma and Metastatic Cancers Malignant Mesothelioma Incidence: 2,500 cases/year ~60-80% pts with pleural MM relationship with asbestos exposure Other risk factors: radiation, other carcinogens,

More information

Histologic Subtypes of Renal Cell Carcinoma

Histologic Subtypes of Renal Cell Carcinoma Histologic Subtypes of Renal Cell Carcinoma M. Scott Lucia, MD Associate Professor Chief of Genitourinary and Renal Pathology Director, Prostate Diagnostic Laboratory Dept. of Pathology University of Colorado

More information

Cytodiagnosis of renal cell carcinoma A case report

Cytodiagnosis of renal cell carcinoma A case report Case Report Cytodiagnosis of renal cell carcinoma A case report Disha Singla 1, Gunvanti Rathod 2* 1 PG Student, 2 Assistant Professor Department of Pathology, SBKS MI & RC, Sumandeep Vidyapeeth, Vadodara,

More information

MAJOR PARADIGM SHIFT IN EARLY 1990S IN UNDERSTANDING RENAL CANCER

MAJOR PARADIGM SHIFT IN EARLY 1990S IN UNDERSTANDING RENAL CANCER Renal tumours WHO 4 MAJOR PARADIGM SHIFT IN EARLY 1990S IN UNDERSTANDING RENAL CANCER Molecular differential pathology of renal cell tumours G. KOVACS A CLASSIFICATION BASED ON UNDERSTANDING THE GENETIC

More information

How To Diagnose And Treat A Tumour In An Effusion

How To Diagnose And Treat A Tumour In An Effusion Effusions of the Serous Cavities Annika Dejmek Professor/Consultant in Cytopathology Clinical Pathology; Department of Laboratory Medicine, Malmö, Lund University 5th EFCS Tutorial Trondheim 2012 Pleura

More information

ORIGINAL ARTICLES. Materials and Methods

ORIGINAL ARTICLES. Materials and Methods ORIGINAL ARTICLES Cytomorphologic Features of Metastatic Urothelial Carcinoma in Serous Effusions Cheng Cheng Huang, M.D., PH.D., 1 Anoja Attele, M.D., 1 and Claire W. Michael, M.D. 2 * Metastatic urothelial

More information

ALTHOUGH excellent accounts have been published in recent years of

ALTHOUGH excellent accounts have been published in recent years of THE EXFOLIATIVE CYTOLOGY OF DIFFUSE MALIGNANT MESOTHELIOMA BERNARD NAYLOR Department of Pathology, University of Michigan, Ann Arbor, Michigan, U.S.A. PLATE~ LXXXVI-XCI ALTHOUGH excellent accounts have

More information

A912: Kidney, Renal cell carcinoma

A912: Kidney, Renal cell carcinoma A912: Kidney, Renal cell carcinoma General facts of kidney cancer Renal cell carcinoma, a form of kidney cancer that involves cancerous changes in the cells of the renal tubule, is the most common type

More information

Case of the. Month October, 2012

Case of the. Month October, 2012 Case of the Month October, 2012 Case The patient is a 47-year-old male with a 3-week history of abdominal pain. A CT scan of the abdomen revealed a suggestion of wall thickening at the tip of the appendix

More information

INFLAMMATION AND REACTIVE CHANGES IN CERVICAL EPITHELIUM

INFLAMMATION AND REACTIVE CHANGES IN CERVICAL EPITHELIUM INFLAMMATION AND REACTIVE CHANGES IN CERVICAL EPITHELIUM Inflammation is a response of a tissue to injury, often caused by invading microorganisms. The suffix which indicates inflammation is "-itis" (the

More information

KIDNEY CARCINOMA ASSOCIATED WITH XP11.2 TRANSLOCATION / TFE3 (ASPL-TFE3) GENE FUSION

KIDNEY CARCINOMA ASSOCIATED WITH XP11.2 TRANSLOCATION / TFE3 (ASPL-TFE3) GENE FUSION Case Report International Braz J Urol Official Journal of the Brazilian Society of Urology KIDNEY CA AND Xp11.2 TRANSLOCATION Vol. 31 (3): 251-255, May - June, 2005 KIDNEY CARCINOMA ASSOCIATED WITH XP11.2

More information

The Value of Thyroid Transcription Factor-1 in Cytologic Preparations as a Marker for Metastatic Adenocarcinoma of Lung Origin

The Value of Thyroid Transcription Factor-1 in Cytologic Preparations as a Marker for Metastatic Adenocarcinoma of Lung Origin Anatomic Pathology / TTF-1 IN CYTOLOGY OF BODY FLUIDS The Value of Thyroid Transcription Factor-1 in Cytologic Preparations as a Marker for Metastatic Adenocarcinoma of Lung Origin Jonathan L. Hecht, MD,

More information

Pleural and Pericardial fluids a one year analysis

Pleural and Pericardial fluids a one year analysis Pleural and Pericardial fluids a one year analysis Dr Olafsdottir Dr J Williams Department of Cytology, Llandough Hospital Contents Background Standards Aims/Questions Investigation group Results Conclusions

More information

DESMOPLASTIC SMALL ROUND CELL TUMOR: A RARE PATHOLOGY PUZZLE

DESMOPLASTIC SMALL ROUND CELL TUMOR: A RARE PATHOLOGY PUZZLE DESMOPLASTIC SMALL ROUND CELL TUMOR: A RARE PATHOLOGY PUZZLE Ryan Granger University of Rhode Island Cytotechnology program May 2, 2015 ASCT Annual Meeting Nashville, Tennessee DESMOPLASTIC SMALL ROUND

More information

Disclosures. Learning Objectives. Effusion = Confusion. Diagnosis Of Serous Cavity Effusions - Beware The Mesothelial Cell!

Disclosures. Learning Objectives. Effusion = Confusion. Diagnosis Of Serous Cavity Effusions - Beware The Mesothelial Cell! Disclosures Diagnosis Of Serous Cavity Effusions - Beware The Mesothelial Cell! No Relevant Financial Relationships with Commercial Interests Syed Z. Ali, M.D. Syed Z. Ali, M.D. Associate Professor of

More information

Renal Tumors with Eosinophilic Cytoplasm: 2013 Classification. Jesse K. McKenney, MD Associate Head, Surgical Pathology

Renal Tumors with Eosinophilic Cytoplasm: 2013 Classification. Jesse K. McKenney, MD Associate Head, Surgical Pathology Renal Tumors with Eosinophilic Cytoplasm: 2013 Classification Jesse K. McKenney, MD Associate Head, Surgical Pathology Renal Epithelial Neoplasia History 1981: WHO Classification of Renal Neoplasms 1.

More information

INTRODUCTION: CASE REPORT:

INTRODUCTION: CASE REPORT: Balekuduru Chaitanya et SYNCHRONOUS OCCURRENCE OF PAPILLARY RENAL CELL CARCINOMA AND TRANSITIONAL UROTHELIAL CELL CARCINOMA OF URINARY BLADDER a case report S. Rajasekhar Reddy 1, Balekuduru Chaitanya*

More information

MALIGNANT MESOTHELIOMA UPDATE ON PATHOLOGY AND IMMUNOHISTOCHEMISTRY

MALIGNANT MESOTHELIOMA UPDATE ON PATHOLOGY AND IMMUNOHISTOCHEMISTRY MALIGNANT MESOTHELIOMA CLASSIFICATION MALIGNANT MESOTHELIOMA UPDATE ON PATHOLOGY AND IMMUNOHISTOCHEMISTRY Sisko Anttila, MD, PhD Jorvi Hospital Laboratory of Pathology Helsinki University Hospital Espoo,

More information

Basic Professional Training Program for Associate Medical Technologist

Basic Professional Training Program for Associate Medical Technologist Basic Professional Training Program for Associate Medical Technologist Basic Cytology Part 2 (Preparartion and normal morphology) Normal Morphology in Liquid based Gynecologic Cytology Speaker: Mr. Fung

More information

Medullary Renal Cell Carcinoma Case Report

Medullary Renal Cell Carcinoma Case Report Bahrain Medical Bulletin, Vol. 27, No. 4, December 2005 Medullary Renal Cell Carcinoma Case Report Mohammed Abdulla Al-Tantawi MBBCH, CABS* Abdul Amir Issa MBBCH, CABS*** Mohammed Abdulla MBBCH, CABS**

More information

MALIGNANT MESOTHELIOMA UPDATE ON PATHOLOGY AND IMMUNOHISTOCHEMISTRY

MALIGNANT MESOTHELIOMA UPDATE ON PATHOLOGY AND IMMUNOHISTOCHEMISTRY MALIGNANT MESOTHELIOMA UPDATE ON PATHOLOGY AND IMMUNOHISTOCHEMISTRY Sisko Anttila, MD, PhD Jorvi Hospital Laboratory of Pathology Helsinki University Hospital Espoo, Finland 2nd Nordic Conference on Applied

More information

WHAT S WRONG WITH MY GALL BLADDER? GALL BLADDER POLYPS

WHAT S WRONG WITH MY GALL BLADDER? GALL BLADDER POLYPS WHAT S WRONG WITH MY GALL BLADDER? GALL BLADDER POLYPS This is a patient information booklet providing specific practical information about gall bladder polyps in brief. Its aim is to provide the patient

More information

ATLAS OF HEAD AND NECK PATHOLOGY THYROID PAPILLARY CARCINOMA

ATLAS OF HEAD AND NECK PATHOLOGY THYROID PAPILLARY CARCINOMA Papillary carcinoma is the most common of thyroid malignancies and occurs in all age groups but particularly in women under 45 years of age. There is a high rate of cervical metastatic disease and yet

More information

CT and MRI features of the Pathologic Subtypes of Papillary Renal Cell Carcinoma. Melissa Price, MD Aoife Kilcoyne, MD Mukesh G.

CT and MRI features of the Pathologic Subtypes of Papillary Renal Cell Carcinoma. Melissa Price, MD Aoife Kilcoyne, MD Mukesh G. CT and MRI features of the Pathologic Subtypes of Papillary Renal Cell Carcinoma Melissa Price, MD Aoife Kilcoyne, MD Mukesh G. Harisinghani, MD Disclosures Neither I nor my immediate family members have

More information

Squamous cell carcinoma located in the renal caliceal system: A case report and review of the literature

Squamous cell carcinoma located in the renal caliceal system: A case report and review of the literature Turkish Journal of Cancer Vol.32/ No. 1/2002 Squamous cell carcinoma located in the renal caliceal system: A case report and review of the literature AYHAN KARABULUT 1, LEVENT EMİR 1, MEHMET GÖNÜLTAŞ 2,

More information

Breast Fine Needle Aspiration Cytology Reporting : A Study of Application of Probabilistic Approach

Breast Fine Needle Aspiration Cytology Reporting : A Study of Application of Probabilistic Approach 54 Original Study Indian Medical Gazette FEBRUARY 2013 Breast Fine Needle Aspiration Cytology Reporting : A Study of Application of Probabilistic Approach Amrish N. Pandya, Professor & Head, IHBT Department,

More information

How To Test For Cancer

How To Test For Cancer Diagnosis Of Serous Cavity Effusions - Beware The Mesothelial Cell! Effusion = Confusion Syed Z. Ali, M.D. Professor of Pathology and Radiology The Johns Hopkins Hospital Baltimore, Maryland Diagnostic

More information

- Slide Seminar - Endocrine pathology in non-endocrine organs. Case 11. Stefano La Rosa, Gioacchino D Ambrosio, Fausto Sessa

- Slide Seminar - Endocrine pathology in non-endocrine organs. Case 11. Stefano La Rosa, Gioacchino D Ambrosio, Fausto Sessa - Slide Seminar - Endocrine pathology in non-endocrine organs Case 11 Stefano La Rosa, Gioacchino D Ambrosio, Fausto Sessa Dept. of Pathology, Multimedica, Milan, Italy Dept. of Surgical and Morphological

More information

Liquid-based cytology

Liquid-based cytology Liquid-based cytology Claire Bourgain UZBrussel Introduction LBC for gynaecological cytology has been introduced in Belgium a decade ago There is no consensus On performance compared to conventional cytology

More information

Immunohistochemistry on cytology specimens from pleural and peritoneal fluid

Immunohistochemistry on cytology specimens from pleural and peritoneal fluid Immunohistochemistry on cytology specimens from pleural and peritoneal fluid Dr Naveena Singh Consultant Pathologist Bart health NHS Trust London United Kingdom Disclosures and Acknowledgements I have

More information

NEOPLASMS OF KIDNEY (RENAL CELL CARCINOMA) And RENAL PELVIS (TRANSITIONAL CELL CARCINOMA)

NEOPLASMS OF KIDNEY (RENAL CELL CARCINOMA) And RENAL PELVIS (TRANSITIONAL CELL CARCINOMA) NEOPLASMS OF KIDNEY (RENAL CELL CARCINOMA) And RENAL PELVIS (TRANSITIONAL CELL CARCINOMA) Merat Esfahani, MD Medical Oncologist, Hematologist Cancer Liaison Physician SwedishAmerican Regional Cancer Center

More information

The Role of Genetic Testing in the Evaluation of Thyroid Nodules. Thyroid Cancer and FNA. Thyroid Cancer. Pure Follicular Cancers.

The Role of Genetic Testing in the Evaluation of Thyroid Nodules. Thyroid Cancer and FNA. Thyroid Cancer. Pure Follicular Cancers. Where does Molecular Analysis of FNA Specimens fit into the evaluation of thyroid nodules? The Role of Genetic Testing in the Evaluation of Thyroid Nodules Ultrasound TSH Risk factors Jill E. Langer, MD

More information

LYMPHOMA. BACHIR ALOBEID, M.D. HEMATOPATHOLOGY DIVISION PATHOLOGY DEPARTMENT Columbia University/ College of Physicians & Surgeons

LYMPHOMA. BACHIR ALOBEID, M.D. HEMATOPATHOLOGY DIVISION PATHOLOGY DEPARTMENT Columbia University/ College of Physicians & Surgeons LYMPHOMA BACHIR ALOBEID, M.D. HEMATOPATHOLOGY DIVISION PATHOLOGY DEPARTMENT Columbia University/ College of Physicians & Surgeons Normal development of lymphocytes Lymphocyte proliferation and differentiation:

More information

Information Model Requirements of Post-Coordinated SNOMED CT Expressions for Structured Pathology Reports

Information Model Requirements of Post-Coordinated SNOMED CT Expressions for Structured Pathology Reports Information Model Requirements of Post-Coordinated SNOMED CT Expressions for Structured Pathology Reports W. Scott Campbell, Ph.D., MBA James R. Campbell, MD Acknowledgements Steven H. Hinrichs, MD Chairman

More information

Epithelial Tumors of the Kidney Diagnostic Problems and Recently Described Entities

Epithelial Tumors of the Kidney Diagnostic Problems and Recently Described Entities Pathology of Renal Neoplasia Epithelial Tumors of the Kidney Diagnostic Problems and Recently Described Entities Wael A Sakr, MD Wayne State University School of Medicine CURRENT CLASSIFICATION = EPITHELIAL

More information

New Concepts and Refinements to. Existing WHO (2004) Renal Cell. Tumor Categories In Adults

New Concepts and Refinements to. Existing WHO (2004) Renal Cell. Tumor Categories In Adults New Concepts and Refinements to Existing WHO (2004) Renal Cell Tumor Categories In Adults Dr Varsha Manucha Assistant Professor Department of Pathology and Laboratory Medicine Temple University Hospital

More information

OBJECTIVES By the end of this segment, the community participant will be able to:

OBJECTIVES By the end of this segment, the community participant will be able to: Cancer 101: Cancer Diagnosis and Staging Linda U. Krebs, RN, PhD, AOCN, FAAN OCEAN Native Navigators and the Cancer Continuum (NNACC) (NCMHD R24MD002811) Cancer 101: Diagnosis & Staging (Watanabe-Galloway

More information

Four Important Facts about Kidney Cancer

Four Important Facts about Kidney Cancer Volume Article.13-11 Publish Date: 24th June 2013 Author(s): MPUH - CRS Team Four Important Facts about Kidney Cancer ARTICLE hhh Muljibhai Patel Urological Hospital (MPUH) Centre For Robotic Surgery (CRS)

More information

1. What is the prostate-specific antigen (PSA) test?

1. What is the prostate-specific antigen (PSA) test? 1. What is the prostate-specific antigen (PSA) test? Prostate-specific antigen (PSA) is a protein produced by the cells of the prostate gland. The PSA test measures the level of PSA in the blood. The doctor

More information

KIDNEY FUNCTION RELATION TO SIZE OF THE TUMOR IN RENAL CELL CANCINOMA

KIDNEY FUNCTION RELATION TO SIZE OF THE TUMOR IN RENAL CELL CANCINOMA KIDNEY FUNCTION RELATION TO SIZE OF THE TUMOR IN RENAL CELL CANCINOMA O.E. Stakhvoskyi, E.O. Stakhovsky, Y.V. Vitruk, O.A. Voylenko, P.S. Vukalovich, V.A. Kotov, O.M. Gavriluk National Canсer Institute,

More information

CASE OF THE MONTH AUGUST-2015 DR. GURUDUTT GUPTA HEAD HISTOPATHOLOGY

CASE OF THE MONTH AUGUST-2015 DR. GURUDUTT GUPTA HEAD HISTOPATHOLOGY CASE OF THE MONTH AUGUST-2015 DR. GURUDUTT GUPTA HEAD HISTOPATHOLOGY CASE HISTORY 52Y MALE RIGHT RADICAL NEPHERECTOMY Case of right renal mass with IVC thrombus. History of surgery and RT for right occipital

More information

20 Diagnostic Cytopathology, Vol 36, No 1 ' 2007 WILEY-LISS, INC.

20 Diagnostic Cytopathology, Vol 36, No 1 ' 2007 WILEY-LISS, INC. Utility of WT-1, p63, MOC31, Mesothelin, and Cytokeratin (K903 and CK5/6) Immunostains in Differentiating Adenocarcinoma, Squamous Cell Carcinoma, and Malignant Mesothelioma in Effusions Robert T. Pu,

More information

Cytology of Effusion Fluids. Cytology of Effusion Fluids. Types of Effusion Fluids. Anatomy. Causes of Effusions. Sampling of Effusion Fluids

Cytology of Effusion Fluids. Cytology of Effusion Fluids. Types of Effusion Fluids. Anatomy. Causes of Effusions. Sampling of Effusion Fluids Cytology of Effusion Fluids John W. Wong, MD, FRCPC Sunnybrook Health Sciences Centre Assistant Professor, Laboratory Medicine and Pathobiology Faculty of Medicine, University of Toronto November 10, 2012

More information

Neoplasms of the LUNG and PLEURA

Neoplasms of the LUNG and PLEURA Neoplasms of the LUNG and PLEURA 2015-2016 FCDS Educational Webcast Series Steven Peace, BS, CTR September 19, 2015 2015 Focus o Anatomy o SSS 2000 o MPH Rules o AJCC TNM 1 Case 1 Case Vignette HISTORY:

More information

General Rules SEER Summary Stage 2000. Objectives. What is Staging? 5/8/2014

General Rules SEER Summary Stage 2000. Objectives. What is Staging? 5/8/2014 General Rules SEER Summary Stage 2000 Linda Mulvihill Public Health Advisor NCRA Annual Meeting May 2014 National Center for Chronic Disease Prevention and Health Promotion Division of Cancer Prevention

More information

Today s Topics. Tumors of the Peritoneum in Women

Today s Topics. Tumors of the Peritoneum in Women Today s Topics Tumors of the Peritoneum in Women Charles Zaloudek, M.D. Department of Pathology 505 Parnassus Ave., M563 University of California, San Francisco San Francisco, CA USA charles.zaloudek@ucsf.edu

More information

The Use of Immunohistochemistry to Distinguish Reactive Mesothelial Cells From Malignant Mesothelioma in Cytologic Effusions

The Use of Immunohistochemistry to Distinguish Reactive Mesothelial Cells From Malignant Mesothelioma in Cytologic Effusions The Use of Immunohistochemistry to Distinguish Reactive Mesothelial Cells From Malignant Mesothelioma in Cytologic Effusions Farnaz Hasteh, MD 1 ; Grace Y. Lin, MD, PhD 1 ; Noel Weidner, MD 1 ; and Claire

More information

Renal Cell Carcinoma Associated with Xp11.2 Translocation: Clinicopathologic and Immunohistochemical Findings of 4 Cases

Renal Cell Carcinoma Associated with Xp11.2 Translocation: Clinicopathologic and Immunohistochemical Findings of 4 Cases The Korean Journal of Pathology 2005; 39: 406-11 Renal Cell Carcinoma Associated with Xp11.2 Translocation: Clinicopathologic and Immunohistochemical Findings of 4 Cases Sanghui Park Ji-Eun Kwon Yeon-Lim

More information

Kidney Cancer OVERVIEW

Kidney Cancer OVERVIEW Kidney Cancer OVERVIEW Kidney cancer is the third most common genitourinary cancer in adults. There are approximately 54,000 new cancer cases each year in the United States, and the incidence of kidney

More information

Cystic renal cell carcinoma rare clinical finding Radiographic variations of tumor/cyst appearance and further diagnostic work-up

Cystic renal cell carcinoma rare clinical finding Radiographic variations of tumor/cyst appearance and further diagnostic work-up 96 Bratisl Lek Listy 2006; 107 (3): 96 100 CASE REPORT Cystic renal cell carcinoma rare clinical finding Radiographic variations of tumor/cyst appearance and further diagnostic work-up Weibl P, Lutter

More information

HKCPath Anatomical Pathology Peer Review and Scores : PDF version for download

HKCPath Anatomical Pathology Peer Review and Scores : PDF version for download AP2003R1 http://hkcpath.org. Correspondence: pkhui@ha.org.hk 1of 10 07/08/2003 HKCPath Anatomical Pathology Peer Review and Scores : PDF version for download AP141 Bone Marrow: Metastatic Carcinoma from

More information

Hematology Morphology Critique

Hematology Morphology Critique Survey Slide: History: 60-year-old female presenting with pneumonia Further Laboratory Data: Hgb : 90 g/l RBC : 2.92 10 12 /L Hct : 0.25 L/L MCV : 87 fl MCH : 30.8 pg MCHC : 355 g/l RDW : 17.7 % WBC :

More information

PRIMARY SEROUS CARCINOMA OF PERITONEUM: A CASE REPORT

PRIMARY SEROUS CARCINOMA OF PERITONEUM: A CASE REPORT PRIMARY SEROUS CARCINOMA OF PERITONEUM: A CASE REPORT Dott. Francesco Pontieri (*) U.O. di Anatomia Patologica P.O. di Rossano (CS) Dott. Gian Franco Zannoni Anatomia Patologica Facoltà di Medicina e Chirurgia

More information

CONTEMPORARY MANAGEMENT OF RENAL ANGIOMYOLIPOMA

CONTEMPORARY MANAGEMENT OF RENAL ANGIOMYOLIPOMA CONTEMPORARY MANAGEMENT OF RENAL ANGIOMYOLIPOMA Stephen A. Boorjian, MD Professor of Urology Vice Chair of Research Director, Urologic Oncology Fellowship Department of Urology Mayo Clinic, Rochester,

More information

Product Datasheet and Instructions for Use

Product Datasheet and Instructions for Use Product Code: MP-378-CMK01 (0.1ml conc) MP-378-CMK05 (0.5ml conc) MP-378-PM6 (6ml RTU) Product Description: CD141 (Thrombomodulin) Concentrated and Prediluted Monoclonal Antibody Control Number: 901-378-071709

More information

Cystic Neoplasms of the Pancreas: A multidisciplinary approach to the prevention and early detection of invasive pancreatic cancer.

Cystic Neoplasms of the Pancreas: A multidisciplinary approach to the prevention and early detection of invasive pancreatic cancer. This lecture is drawn from the continuing medical education program Finding Hope: Prevention, Early Detection and Treatment of Pancreatic Cancer, Nov, 2011. Robert P. Jury, MD Cystic Neoplasms of the Pancreas:

More information

PATHOLOGY OF THE PLEURA: Mesothelioma and mimickers Necessity of Immunohistochemistry. M. Praet

PATHOLOGY OF THE PLEURA: Mesothelioma and mimickers Necessity of Immunohistochemistry. M. Praet PATHOLOGY OF THE PLEURA: Mesothelioma and mimickers Necessity of Immunohistochemistry M. Praet Pathology of the Pleura Normal serosa: visceral and parietal layers Inflammation Neoplasia: Primary: mesothelioma

More information

Fine Needle Aspiration Cytologic Features of Well-Differentiated Papillary Mesothelioma in the Pleura

Fine Needle Aspiration Cytologic Features of Well-Differentiated Papillary Mesothelioma in the Pleura The Korean Journal of Pathology 2009; 43: 583-8 DOI: 10.4132/KoreanJPathol.2009.43.6.583 Fine Needle Aspiration Cytologic Features of Well-Differentiated Papillary Mesothelioma in the Pleura - A Case Report

More information

MALIGNANT MESOTHELIOMA: A TYPICAL PRESENTATION IN AN ATYPICAL PATIENT

MALIGNANT MESOTHELIOMA: A TYPICAL PRESENTATION IN AN ATYPICAL PATIENT MALIGNANT MESOTHELIOMA: A TYPICAL PRESENTATION IN AN ATYPICAL PATIENT Written by: Karyn Varley MS, SCT(ASCP) The donating laboratory would like to remain anonymous. PATIENT HISTORY 28 year old female Lived

More information

Male. Female. Death rates from lung cancer in USA

Male. Female. Death rates from lung cancer in USA Male Female Death rates from lung cancer in USA Smoking represents an interesting combination of an entrenched industry and a clearly drug-induced cancer Tobacco Use in the US, 1900-2000 5000 100 Per Capita

More information

A Very Rare Indication in Urology: Ablation of all the Urinary Organs: About A Case

A Very Rare Indication in Urology: Ablation of all the Urinary Organs: About A Case Article ID: WMC002102 ISSN 2046-1690 A Very Rare Indication in Urology: Ablation of all the Urinary Organs: About A Case Author(s):Dr. Hatim El Karni, Dr. Bezzaz Aicha, Dr. El Ghanmi Jihad, Dr. Koutani

More information

Open the Flood Gates Urinary Obstruction and Kidney Stones. Dr. Jeffrey Rosenberg Dr. Emilio Lastarria Dr. Richard Kasulke

Open the Flood Gates Urinary Obstruction and Kidney Stones. Dr. Jeffrey Rosenberg Dr. Emilio Lastarria Dr. Richard Kasulke Open the Flood Gates Urinary Obstruction and Kidney Stones Dr. Jeffrey Rosenberg Dr. Emilio Lastarria Dr. Richard Kasulke Nephrology vs. Urology Nephrologist a physician who has been trained in the diagnosis

More information

WHICH SAMPLES SHOULD BE SUBMITTED WHEN LYMPHOID NEOPLASIA IS SUSPECTED?

WHICH SAMPLES SHOULD BE SUBMITTED WHEN LYMPHOID NEOPLASIA IS SUSPECTED? WHICH SAMPLES SHOULD BE SUBMITTED WHEN LYMPHOID NEOPLASIA IS SUSPECTED? Which test should be submitted? The answer to this depends on the clinical signs, and the diagnostic question you are asking. If

More information

FULLY AUTOMATED PARALLEL DUAL STAINING DETECTION SYSTEM. ChromoPlex 1 Dual Detection for BOND

FULLY AUTOMATED PARALLEL DUAL STAINING DETECTION SYSTEM. ChromoPlex 1 Dual Detection for BOND ChromoPlex 1 Dual Detection for BOND FULLY AUTOMATED PARALLEL DUAL STAINING DETECTION SYSTEM View multiple antibodies on a single slide to deliver a comprehensive clinical result. 1 MULTIPLY YOUR CAPABILITIES

More information

Validation of BRAF Mutational Analysis in Thyroid Fine Needle Aspirations: A Morphologic- Molecular Approach

Validation of BRAF Mutational Analysis in Thyroid Fine Needle Aspirations: A Morphologic- Molecular Approach Validation of BRAF Mutational Analysis in Thyroid Fine Needle Aspirations: A Morphologic- Molecular Approach Kerry C. Councilman, MD Assistant Professor University of Colorado Denver Goals: BRAF Mutation

More information

Introduction: Tumor Swelling / new growth / mass. Two types of growth disorders: Non-Neoplastic. Secondary / adaptation due to other cause.

Introduction: Tumor Swelling / new growth / mass. Two types of growth disorders: Non-Neoplastic. Secondary / adaptation due to other cause. Disorders of Growth Introduction: Tumor Swelling / new growth / mass Two types of growth disorders: Non-Neoplastic Secondary / adaptation due to other cause. Neoplastic. Primary growth abnormality. Non-Neoplastic

More information

GENERAL CODING. When you review old cases that were coded to unknown, make corrections based on guidelines in effect at the time of diagnosis.

GENERAL CODING. When you review old cases that were coded to unknown, make corrections based on guidelines in effect at the time of diagnosis. GENERAL CODING When you review old cases that were coded to unknown, make corrections based on guidelines in effect at the time of diagnosis. Exception: You must review and revise EOD coding for prostate

More information

Malignant Lymphomas and Plasma Cell Myeloma

Malignant Lymphomas and Plasma Cell Myeloma Malignant Lymphomas and Plasma Cell Myeloma Dr. Bruce F. Burns Dept. of Pathology and Lab Medicine Overview definitions - lymphoma lymphoproliferative disorder plasma cell myeloma pathogenesis - translocations

More information

Tumour Markers. What are Tumour Markers? How Are Tumour Markers Used?

Tumour Markers. What are Tumour Markers? How Are Tumour Markers Used? Dr. Anthony C.H. YING What are? Tumour markers are substances that can be found in the body when cancer is present. They are usually found in the blood or urine. They can be products of cancer cells or

More information

J of Evidence Based Med & Hlthcare, pissn- 2349-2562, eissn- 2349-2570/ Vol. 2/Issue 33/Aug. 17, 2015 Page 5063

J of Evidence Based Med & Hlthcare, pissn- 2349-2562, eissn- 2349-2570/ Vol. 2/Issue 33/Aug. 17, 2015 Page 5063 PERITONEAL MALIGNANT MESOTHELIOMA: A RARE S. R. Dhamotharan 1, S. Shanthi Nirmala 2, F. Celine Foustina Mary 3, M. Arul Raj Kumar 4, R. Vinothprabhu 5 HOW TO CITE THIS ARTICLE: S. R. Dhamotharan, S. Shanthi

More information

Seattle. Case Presentations. Case 1. 76 year old female with a history of breast cancer 12 years ago. Now presents with a pleural effusion.

Seattle. Case Presentations. Case 1. 76 year old female with a history of breast cancer 12 years ago. Now presents with a pleural effusion. Seattle Montreal IAP September 2006 Case Presentations Allen M. Gown, M.D. Medical Director and Chief Pathologist PhenoPath Laboratories Clinical Professor of Pathology University of British Columbia Case

More information

TUMORS OF THE TESTICULAR ADNEXA and SPERMATIC CORD

TUMORS OF THE TESTICULAR ADNEXA and SPERMATIC CORD TUMORS OF THE TESTICULAR ADNEXA and SPERMATIC CORD Victor E. Reuter, MD Memorial Sloan-Kettering Cancer Center reuterv@mskcc.org 66 th Annual Pathology Seminar California Society of Pathologists Short

More information

Immunohistochemical differentiation of metastatic tumours

Immunohistochemical differentiation of metastatic tumours Immunohistochemical differentiation of metastatic tumours Dr Abi Wheal ST1. TERA 3/2/14 Key points from a review article written by Daisuke Nonaka Intro Metastatic disease is the initial presentation in

More information

Translocation Renal Cell Carcinomas

Translocation Renal Cell Carcinomas Translocation Renal Cell Carcinomas Cora N. Sternberg, MD, FACP Chair, Department of Medical Oncology San Camillo and Forlanini Hospitals Rome, Italy Kidney cancer is not a single disease Clear cell (75%)

More information

PCA3 DETECTION TEST FOR PROSTATE CANCER DO YOU KNOW YOUR RISK OF HAVING CANCER?

PCA3 DETECTION TEST FOR PROSTATE CANCER DO YOU KNOW YOUR RISK OF HAVING CANCER? PCA3 DETECTION TEST FOR PROSTATE CANCER DO YOU KNOW YOUR RISK OF HAVING CANCER? PCA3 DETECTION TEST FOR PROSTATE CANCER There is a range of methods available to your healthcare professional to verify the

More information

Emerging Subtypes in Renal Cancer. Donna E. Hansel, MD PhD Professor of Pathology, UC San Diego Division Chief, Anatomic Pathology dhansel@ucsd.

Emerging Subtypes in Renal Cancer. Donna E. Hansel, MD PhD Professor of Pathology, UC San Diego Division Chief, Anatomic Pathology dhansel@ucsd. Emerging Subtypes in Renal Cancer Donna E. Hansel, MD PhD Professor of Pathology, UC San Diego Division Chief, Anatomic Pathology dhansel@ucsd.edu Some General Comments Fuhrman nuclear grading clear cell

More information

The Diagnosis of Cancer in the Pathology Laboratory

The Diagnosis of Cancer in the Pathology Laboratory The Diagnosis of Cancer in the Pathology Laboratory Dr Edward Sheffield Christmas Select 74 Meeting, Queen s Hotel Cheltenham, 3 rd December 2014 Agenda Overview of the pathology of cancer How specimens

More information

Metastatic Renal Cell Carcinoma: Staging and Prognosis of Three Separate Cases.

Metastatic Renal Cell Carcinoma: Staging and Prognosis of Three Separate Cases. Metastatic Renal Cell Carcinoma: Staging and Prognosis of Three Separate Cases. Abstract This paper describes the staging, imaging, treatment, and prognosis of renal cell carcinoma. Three case studies

More information

Thyroid Fine-Needle Aspiration Indications and Technique. Subcommittee members Zubair W. Baloch, MD, PhD Martha Bishop Pitman, MD

Thyroid Fine-Needle Aspiration Indications and Technique. Subcommittee members Zubair W. Baloch, MD, PhD Martha Bishop Pitman, MD Thyroid Fine-Needle Aspiration Indications and Technique Subcommittee members Zubair W. Baloch, MD, PhD Martha Bishop Pitman, MD Thyroid FNA Indication Clinical Thyroid Nodule (s) > 1 cm? Hypo-functioning

More information

Cytology of Malignant Mesothelioma

Cytology of Malignant Mesothelioma 31 Cytology of Malignant Mesothelioma Richard M. DeMay Because patients with mesotheliomas frequently present with effusions, cytologic examination of the effusion fluid may be the first diagnostic study.

More information

Smoking and misuse of certain pain medicines can affect the risk of developing renal cell cancer.

Smoking and misuse of certain pain medicines can affect the risk of developing renal cell cancer. Renal cell cancer Renal cell cancer is a disease in which malignant (cancer) cells form in tubules of the kidney. Renal cell cancer (also called kidney cancer or renal adenocarcinoma) is a disease in which

More information

These rare variants often act aggressively and may respond differently to therapy than the more common prostate adenocarcinoma.

These rare variants often act aggressively and may respond differently to therapy than the more common prostate adenocarcinoma. Prostate Cancer OVERVIEW Prostate cancer is the second most common cancer diagnosed among American men, accounting for nearly 200,000 new cancer cases in the United States each year. Greater than 65% of

More information

Video Microscopy Tutorial 5

Video Microscopy Tutorial 5 Video Microscopy Tutorial 5 Lool Alikes in Effusion Cytology:Review of Diagnostic Challenges Claire Michael, MD There are no disclosures necessary. Look-Alikes in Effusion Cytology: Review of Diagnostic

More information

Guideline for the Imaging of Patients Presenting with Breast Symptoms incorporating the guideline for the use of MRI in breast cancer

Guideline for the Imaging of Patients Presenting with Breast Symptoms incorporating the guideline for the use of MRI in breast cancer Guideline for the Imaging of Patients Presenting with Breast Symptoms incorporating the guideline for the use of MRI in breast cancer Version History Version Date Summary of Change/Process 0.1 09.01.11

More information

PROTOCOL. Immunocytochemistry (ICC) MATERIALS AND EQUIPMENT REQUIRED

PROTOCOL. Immunocytochemistry (ICC) MATERIALS AND EQUIPMENT REQUIRED PROTOCOL Immunocytochemistry (ICC) 1850 Millrace Drive, Suite 3A Eugene, Oregon 97403 11-07 MATERIALS AND EQUIPMENT REQUIRED Materials: MitoSciences primary monoclonal antibody/antibodies Fluorophore-conjugated

More information

Polyps. Hyperplasias. CAP 2011: Course AP104. The High Risk Benign Endometrium. Mutter and Nucci 1

Polyps. Hyperplasias. CAP 2011: Course AP104. The High Risk Benign Endometrium. Mutter and Nucci 1 Course AP104 Endometrial Hyperplasia A morphologic Definition Hyperplasias Hormonal Effect or Precancer? George L. Mutter, MD Harvard Medical School and Brigham and Women s Hospital Boston, MA Endometrial

More information

A 70-year old Man with Pleural Effusion

A 70-year old Man with Pleural Effusion Mesothelioma Diagnosis: Pitfalls and Latest Updates S Klebe and DW Henderson Recommendations Indisputable malignant cells on cytomorphological criteria which demonstrate a mesothelial phenotype, which

More information