A study on new products. available in India for. diabetics. Note: Source:

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1 A study on new products available in India for diabetics

2 Novo Nordisk In one generation, the prevalence of diabetes has increased SIX fold

3 Incidence of Diabetes Europe 2000: 33.3 Million 2030: 48.0 Million The Americas 2000: 33.0 Million 2030: 66.8 Million Africa 2000: 7.0 Million 2030: 18.2 Million The Middle East 2000: 15.2 Million 2030: 42.6 Million Asia 2000: 81.7 Million 2030: Million Australia 2000: 1.0 Million 2030: 1.7 Million In the year 2000, there were 171 Million diabetics in the world. The number is expected to increase to 366 Million by India, China and United States account for 30% of the world s diabetic population World Health Organization; Grail Research Analysis

4 Diabetes is most prevalent in the following 10 countries: India China USA Indonesia Japan Pakistan Russia Brazil Italy Bangladesh Prevalence of Diabetes Ranking Country People with Diabetes (MM) Year 2000 People with Diabetes (MM) Year India China USA World Health Organization It is estimated that India will continue to have the largest number of diabetics in the world, even in 2030

5 Rapid urbanization and industrialization leads to lifestyle changes which adversely affect the risk factors associated with diabetes. Dr A. Ramachandran of Chennai s Diabetes Research Centre and M.V. Hospital For Diabetes Eyes The Major Diabetic Complications (Retinopathy) Heart & Coronary Circulation (Coronary Heart disease) Brian and Cerebral Circulation (Cerebrovascular Disease) Kidney (Nephropathy) Various studies have shown that the high incidence of diabetes in India is mainly Hindustan Times Business World; International Diabetes Federation; Hindustan Times; World Health Organization because of sedentary lifestyle, lack of physical activity, obesity, stress and consumption of diets rich in fat, sugar and calories. Lower Limbs (Peripheral Vascular Disease) Peripheral Nervous System (Neuropathy) Feet (Diabetic Foot Ulceration and Amputation) In areas such as the Middle East and countries in the Pacific region, one out of four deaths for year-olds is due to diabetes Cardiovascular disease is the cause of 50-80% of all deaths among diabetics

6 Projected Loss in National Income Due to Chronic Diseases (USD Bn) Loss in 2005 Loss in 2015 Average Annual Loss Income Loss as a % of GDP in 2015 China Russia India Brazil U.K Pakistan Canada Nigeria Tanzania Global spending on diabetes treatment is expected to increase from USD 232 Bn in 2007 to USD 303 Bn in 2025 Indian Council For Research On International Economic Relations; Novo Nordisk; International Diabetes Federation

7 USD Bn Global Market for Diabetes Drugs (USD Bn) USD Bn Indian Market for Diabetes Drugs (USD Bn) E Insulin Oral drugs 1 Insulin Oral drugs 3 In 2005, the mean estimated annual cost for diabetes per individual in India was USD 418 Indirect costs, which include measures of productivity and income loss through illness, represented USD 267 per individual Direct costs such as drug treatment, check-ups, etc. approximated USD 99 per individual Hospitalization costs were estimated to be USD 51 In the US, diabetics spend an average of USD 13,243 on healthcare every year, well above the estimated annual healthcare expense of USD 2,560 associated with non-diabetics The Indian market for oral diabetes treatments is growing at an annual rate of 14%, more than double the 6.3% global growth rate 1 Oral antibiotic drugs; 2 Converted to USD using average rate of conversion for the period October 2006-October 2007; 3 Oral Hypoglycemic Agents (OHA) The World Diabetes Market, ; PwC; The Financial Express; dlife; Global Forum for Health; Centre for Prevention and Health Services

8 Prof. Lefebvre, President, International Diabetes Federation In 2003, there were 189 million diabetics in the world. The projected figure for 2025 is 324 million. And we have reason to believe that the projection is an underestimation. Products for Diabetes Sugar-free products are selling the fastest in the health food category In the last two years, the sale of health food has shot up by about 40 percent. Rajesh Sanklecha, Manager, Nuts n Spices, a department store chain in India The Hindu; Business Line

9 Amul is India s top brand according to a 2007 Brand Survey 1 Amul, which means priceless, is derived from the Sanskrit word Amoolya It is a brand of Gujarat Cooperative Milk Marketing Federation (GCMMF) GCMMF s 2.6 MM producer members collected 2.38 Bn liters of milk in , a daily collection average of 6.5 MM liters In the financial year , GCMMF posted sales of USD1.05 Bn Amul ventured into sugar free desserts through Amul Sugar Free Probiotic Frozen Desserts and has now also launched sugar free chocolates aimed specifically at diabetics Notes: 1 Asia s Top 1000 Brands Survey by Media, Asian Integrated Media Ltd and Synovate Amul website; Synovate website

10 The Saffola brand belongs to Marico Industries, one of India s leading FMCG companies, generating revenue of USD 380 MM Print Ad Saffola launched Atta (Wheat flour) additives to help control sugar and cholesterol levels The staple use of Atta is to make rotis (a type of Indian bread) which is widely used in daily foods all over India India consumed approximately 40 million tons of Atta in 2004 Brands like Saffola have launched innovative food additives for sugar management. Variants of this product are also available to help control cholesterol intake. Saffola website; Marico industries website; Business Line Saffola website; Marico industries website; Business Line

11 diabetes. Nouveau Diététique would like to reverse this scenario by It is unnerving to find that some 10 year olds are diagnosed with introducing tasty and healthy substitutes to the unhealthy foods we are eating today - Nouveau Diététique Website Nouveau Diététique s product portfolio includes offerings geared for diabetics and obese people, ranging from diabetic dietary supplements to sugar-free chocolate Nouveau Diététique website Soluble fibers like Galactomannan are believed to help slow down the conversion of carbohydrates to glucose and hence improve its subsequent absorption

12 Horlicks, one of India s leading health food drinks, is a brand of GlaxoSmithKline s Consumer Healthcare division In 2004, Horlicks controlled more than half of the Indian health food drink market 1 Horlicks launched two diabetic-friendly products in September 2005 Horlicks Lite health food drink and Horlicks Lite Bite biscuits Both products are endorsed and certified by Diabetes India, the largest body of participating endocrinologists, medical specialists, physicians and researchers interested in the study of diabetes Horlicks lite health food drink and Horlicks lite Bite biscuits have been formulated for the nutritional needs of adults and are promoted for safe use by diabetics 1 The Economic Times Survey, 2004 GlaxoSmithKline Consumer Healthcare India website

13 ICICI Prudential Life Insurance is a joint venture between Prudential plc, an international financial services group, and ICICI Bank, one of India s leading financial services companies ICICI Prudential is ranked second 1 among the insurance sector companies of India In November 2006, ICICI Prudential launched India s first insurance policy specifically tailored to the needs of diabetics ICICI Prudential currently offers two types of insurance policies for diabetics: Diabetes Care: Critical illness insurance policy for Type 2 diabetics and pre-diabetics Diabetes Care Plus: Critical illness and death insurance policy for Type 2 diabetics and prediabetics With India being termed the Diabetes Capital of the World, insurance companies such as ICICI Prudential have introduced new insurance products specifically tailored to diabetics Notes: 1 According to the Businessworld s Most Respected Company Survey of 2006 ICICI Prudential website; Businessworld; DNA India website

14 Done Type 2 Diabetes People suffering from type 2 diabetes are unable to use the insulin produced in the body effectively It is possible to manage this type of diabetes with lifestyle changes and oral drugs, although insulin may also be required Symptoms of type 2 diabetes are similar to type 1 diabetes, though less obvious Often, people with type 2 diabetes have no symptoms and the disease goes undiagnosed for a long period after its onset Type 1 Diabetes Type 1 diabetes is usually diagnosed in children or young adults and was formerly referred to as juvenile diabetes People suffering from type 1 diabetes either produce very little or no insulin at all Daily injections of insulin are required to manage the disease Some of the symptoms of type 1 diabetes include excessive thirst; constant hunger; excessive urination; weight loss for no reason; rapid, hard breathing; vision changes; drowsiness or exhaustion Gestational Diabetes Gestational diabetes mellitus (GDM) develops during pregnancy and usually goes away after pregnancy The chances of GDM sufferers developing type 2 diabetes in the future is high GDM affects around 4% of pregnant women in US every year American Diabetes Association; World Health Organization Types of Diabetes

15 For More Information Contact: Grail Research Copyright 2007 by Grail Research, a division of Integreon No part of this publication may be reproduced, stored in a retrieval system, or transmitted in any form or by any means electronic, mechanical, photocopying, recording, or otherwise without the permission of Grail Research, a division of Integreon