CURRICULUM VITAE HANNEKE E.M. DEN OUDEN PHD Aug-15

Transcription

1 Contact Information Address Donders Institute for Brain, Cognition and Behaviour Centre for Cognitive Neuroimaging Kapittelweg EN Nijmegen, the Netherlands Phone (office/mobile) +31 (0) / +31(0) h.denouden@donders.ru.nl Academic Positions and Education Donders Institute for Brain Cognition and Behaviour New York University Donders Institute for Brain Cognition and Behaviour University College London Veni Laureate Fellow / Senior Researcher Radboud University Nijmegen, Nijmegen, Netherlands (Jul 2012 present) Postdoctoral Fellow Advisor: Prof. N Daw, Center for Neural Science & Department of Psychology (Jun 2011 Jun 2013) Postdoctoral Fellow Advisor: Prof. R. Cools, Radboud University Nijmegen, Nijmegen, Netherlands (April 2009-June 2011) Wellcome Trust PhD in Neuroscience, Submitted: April 2009; Defended: July Thesis: Predictionerror dependent changes during associative learning. Advisors: Prof. KE Stephan, Prof. KJ Friston Utrecht University MSc Neuroscience, cum laude (August 2004) Incl. research project at Institute of Cognitive Neuroscience, University College London, and Department of Psychology, Harvard University. Thesis supervisor: Prof. SJ Blakemore, UCL University College Utrecht BSc Life Sciences, summa cum laude (Sept 2002) GPA 3.98, 1 st of class Honours thesis in Psychology Research Domains Interests: Mechanisms of motivational control, Fronto-striatal circuits, Psychiatric disorders (depression, anxiety disorders, OCD), Neural prediction error coding, Reinforcement learning, Serotonin, Dopamine, Behavioural genetics & pharmacology, and Neuroimaging (fmri, EEG). Quantitative Skills: Advanced (model-based) neuroimaging analysis methods Dynamic causal modelling, Computational models of reinforcement learning, Bayesian model comparison.

2 Research Grants 2015 Donders Centre for Cognition Research Fellowship 10, Research talent grant by the Netherlands Organisation for Scientific 171,362 Research (NWO) for a PhD student Project title: Overcoming affective biases of decision-making - Combining neurophysiology, neurostimulation and computational psychology 2011 Veni grant by the Netherlands Organisation for Scientific Research: 250,000 Project title: Learning to go - Frontostriatal coupling and the interaction between motivation and action 2010 AXA Research Fund postdoctoral fellowship 50,000 Project title: The role of dopamine in learning to approach or avoid - Pharmacological neuroimaging and connectivity in Parkinson s disease (declined because of conflict with VENI grant) year PhD Neuroscience Wellcome Trust Prize Studentship, University College London 126,000 Research and Training Fellowships 2007 Computational Neuroscience summer school, Okinawa Institute of Science and Technology, Japan 2006 Schizophrenia and Related Disorders summer school, Cold Spring Harbor Laboratories, USA 2004 Royal Society Summer studentship with Prof. S.J. Blakemore, UCL, UK 5,000 Honours and Awards 2012 Federation for European Neurosciences Travel Award Brain Travel Award for travel to OHBM with abstract: Striatal prediction 800 error modulates cortical coupling during associative learning OHBM Student Travel Award with abstract: Striatal prediction error $ 800 modulates cortical coupling during associative learning Brain Connectivity Workshop Travel Grant, Sendai, Japan 1, Hersenstichting student travel grants for MSc project on: Adolescent 800 development of the neural circuitry for thinking about intentions Dutch society for neuropsychology travel grant for MSc project on: 1000 Adolescent development of the neural circuitry for thinking about intentions Student travel award University College Utrecht for conference on 500 Touch, Blindness and Neuroscience, UNED, Madrid, with abstract: The role of locomotor information in distance reproduction without vision Class Valedictorian, University College Utrecht. Top grades in class

3 Peer-reviewed Journal Publications * indicates key publication, indicates equal contribution H index (google scholar): 17 I 10 index (google scholar): Cook J, den Ouden HEM, Hayes C, Cools R. (2014) The social dominance paradox: learning from others when you believe you're self-sufficient. Current Biology 24: * Den Ouden HEM, Swart JC, Schmidt K, Fekkes D, Geurts DEM, Cools R. (2015) Acute serotonin depletion releases motivated inhibition of response vigour. Psychopharmacology 232(7): * Den Ouden HEM, Daw ND, Fernandez G, Elshout JA, Rijpkema M, Hoogman M, Franke B, Cools R (2013). Dissociable effects of serotonin and dopamine on reversal learning. Neuron, 80(4): Sescousse GS, den Ouden HEM (2013). Gambling rats and gambling addiction: reconciling the role of dopamine in irrationality. Journal of neuroscience, 33(8), Van Schouwenburg MR, den Ouden HEM, Cools RC (2013). Selective attentional gating by the basal ganglia during spatial attention switching. Cerebral Cortex (bht345) 6. Geurts DEM, Huys QJM, den Ouden HEM, Cools R (2013) Serotonin and aversive Pavlovian control of instrumental behavior in humans. Journal of Neuroscience 33(48), Iglesias S, Mathys C, Brodersen KH, Kasper L, Piccirelli M, den Ouden HEM, Stephan KE (2013). Hierarchical prediction errors in dopaminergic and cholinergic regions during sensory learning. Neuron, 80(2), Geurts DEM, Huys QJM, den Ouden HEM, Cools RC (2013). Aversive Pavlovian control of instrumental behaviour in humans. Journal of cognitive neuroscience, 25(9), Volman I, Verhagen L, den Ouden HEM, Toni I, Roelofs K (2013). Reduced serotonin transporter availability decreases prefrontal control of the amygdala. Journal of neuroscience, 33(21), * Den Ouden HEM, Kok P, De Lange F (2012). Prediction errors in perception, attention and motivation. Frontiers in psychology, 3, Crockett MJ, Clark L, Roiser JP, Robinson OJ, Cools RC, Chase HW, den Ouden H, Apergis- Schoute A, Campbell-Meikeljohn, Seymour B, Sahakian BJ, Rogers RD, Robbins TW (2012). Converging evidence for central 5-HT effects in acute tryptophan depletion. Molecular psychiatry, 17(2), Van Leeuwen T, den Ouden HEM, Hagoort P (2011). Effective connectivity determines subjective experiences in grapheme-color synesthesia. Journal of neuroscience, 31(27), * Den Ouden HEM, Daunizeau J, Roiser J, Friston KJ, Stephan KE (2010). Striatal prediction error drives cortical connectivity changes during associative learning. Journal of neuroscience, 30(9), covered in Journal Club article de-wit et al. JNeurosci Daunizeau J, den Ouden HEM, Pessiglione M, Stephan KE, Kiebel SJ & Friston KJ (2010). Observing the observer(i): Meta-Bayesian models of learning and decision-making. PloS one, 5(12), e Daunizeau J, den Ouden HEM, Pessiglione M, Stephan KE, Kiebel SJ & Friston KJ (2010). Observing the observer (II): Deciding when to decide. PloS one, 5(12), e15555

4 16. Van Schouwenburg M, den Ouden HEM, Cools RC (2010). The human basal ganglia modulate frontal-posterior connectivity during attention shifting. Journal of neuroscience, 30(29), Roiser JP, Stephan KE, den Ouden HEM, Friston KJ, & Joyce EM (2010). Adaptive and aberrant reward signals in the human brain. NeuroImage, 50(2), Stephan KE, Penny WD, Moran RJ, den Ouden HEM, Daunizeau J, Friston KJ (2010). Ten simple rules for Dynamic Causal Modelling. NeuroImage, 49(4), * Den Ouden HEM, Friston KJ, Daw ND, McIntosh AR, & Stephan KE (2009). A dual role for prediction error in associative learning. Cerebral cortex, 19(5), Roiser JP, Stephan KE, den Ouden HEM, Barnes TR, Friston KJ, & Joyce EM (2009). Do patients with schizophrenia exhibit aberrant salience? Psychological medicine, 39(2), Stephan KE, Kasper L, Harrison LM, Daunizeau J, den Ouden HEM, Breakspear M, & Friston KJ (2008). Nonlinear dynamic causal models for fmri. NeuroImage, 42(2), Blakemore S-J, den Ouden HEM, Choudhury S, & Frith C (2007). Adolescent development of the neural circuitry for thinking about intentions. Social cognitive and affective neuroscience, 2(2), Den Ouden HEM, Frith U, Frith C, & Blakemore S-J (2005). Thinking about intentions. NeuroImage, 28(4), Den Ouden HEM, van Ee ER, & de Haan EH (2005). Colour helps to solve the binocular matching problem. Journal of physiology, 567(Pt 2), Invited Book chapters 1. Den Ouden HE, Pijpers WGE, Jehoel S, Wiersma V, Postma A (2004). The role of locomotor information in distance reproduction without vision. In: Touch, Blindness, and Neuroscience. Editors: Ballesteros S & Heller. UNED Press, Madrid 2. Den Ouden HEM, Huys QJM, Cools R. (in preparation). How do emotions and cognition interact? In The Nature of Emotion. Editors: Andrew S Fox, Regina C. Lapate, Alexander J. Shackman & Richard J. Davidson. Manuscripts under Review 1. Piray P, den Ouden HEM, van der Schaaf ME, Toni I, Cools R. Trait impulsivity predicts the effects of dopamine on ventro-dorsal striatal connectivity (in revision, Cerebral Cortex). 2. Heinzle J, KoopmansPJ, den Ouden HEM, Raman SS, Stephan KE. A hemodynamic model for layered BOLD signals. (in revision, NeuroImage) 3. Kroes MCW, Tona KD, den Ouden HEM, Vogel S, van Wingen GA, Fernandez G. Unraveling the mechanisms underlying the sustained loss of fear following noradrenergic blockade during extinction learning (submitted) 4. Dirkx MF, den Ouden HEM, Aarts E, Timmer M, Cools R, Esselink R, Bloem BR, Toni I, Helmich RC. Cerebral mechanisms underlying initiation and propagation of Parkinson s tremor Manuscripts in preparation 1. Den Ouden HEM, Daw ND, Cools RC. Serotonin depletion abolishes prefrontal responses during Pavlovian-instrumental incongruent responding. 2. Geurts DEM, den Ouden HEM. Dopaminergic effects on Pavlovian-Instrumental Transfer depend on working memory capacity

5 3. Swart JC, Froboese M, Geurts DEM, Fallon SJ, Cools RC, den Ouden HEM. Methylphenidate effects on the trade-off of instrumental credit assignment and Pavlovian biases 4. Sjoerds Z, den Ouden HEM. Computationele Psychiatrie. Neuropraxis (invited article; Dutch journal for medical practitioners on recent advances and developments in neuroscience) Teaching International Teaching Each course includes lectures and workshops/tutorials. In the methodological courses I teach on a range of topics, including brain connectivity (DCM, PPI) and other model-based fmri analyses, Bayesian model comparison and reinforcement learning Neurocomputational approaches to Decision Making Summer School, Donders Institute, Nijmegen, Netherlands 2015 Neurocomputational approaches to Neuroimaging Toolkit, Donders Institute, Nijmegen, Netherlands 2013 Summer school on Brain Networks and Neural Communication, Nijmegen, Netherlands Advanced methods in Neuroimaging SPM course, ETH / University of Zurich Advanced SPM short course, NeuroImage Nord, Hamburg, Germany Donders Toolkit for Advanced fmri Analysis, Donders Institute, Radboud University, Nijmegen SPM short course, Wellcome Trust Centre for NeuroImaging, UCL, London, UK 2010 A practical and theoretical intro to fmri, FENS satellite symposium, Utrecht University Advanced methods in Neuroimaging SPM course, ETH / University of Zurich Internal Teaching Each course includes lecture as well as exam preparation/marking 2014 BSc Pharmacology, Dopaminology, Psychopharmacology and Psychopathology, Radboud University Nijmegen, Netherlands MSc Cognitive Neuroscience, Dopamine and Reinforcement learning, Cognitive Control, Radboud University Nijmegen, Netherlands 2015 MSc Cognitive Neuroscience, Cruise control or in control? The neural and cognitive mechanisms of reflective versus reflexive decision-making, Cognitive Control, Radboud University Nijmegen, Netherlands MSc Cognitive Neuroscience,Brain Connectivity, Neuroimaging II: Haemodynamic methods, Radboud University Nijmegen, Netherlands BSc Computer Science, DCM and fmri measures of effective connectivity, Brain Dynamics & Connectivity, Radboud University Nijmegen, Netherlands Course organiser, Methods for Dummies, Wellcome Trust Centre for NeuroImaging, University College London, UK

6 Academic Supervision Primary supervisor Jennifer Swart, Research assistant ( ), PhD Cognitive Neuroscience, Radboud University, 2014-present Overcoming affective biases of decision-making: Combining neurophysiology, neurostimulation and computational psychology. Dr. Martin Guthrie, senior research assistant, 2014-present Dopamine and serotonin genetic pathways in reversal learning Jessica Maatta, MSc Cognitive Neuroscience, Radboud University, 2015-present Prefrontal theta: Credit assignment or Pavlovian control? Joris van Elshout, post-graduate research assistant, current position: PhD candidate at Radboud University (supervisor: prof. Bert van den Berg) Kristin Schmidt, post-graduate research assistant current position: PhD candidate at Oxford University, UK (supervisor: prof. Catherine Harmer) Co-supervisor Marpessa Rietbergen, PhD Cognitive Neuroscience, Radboud University, 2015-present Basal ganglia thalamocortical mechanisms of cognitive control in speaking Annelies van Nuland, Radboud University, 2013 present MSc: The role of striatal GABA in human reward processing (cum laude honours) PhD: Pavlovian and instrumental control in Parkinson s disease Dirk Geurts, PhD Neuroscience / Psychiatrist in training, Radboud University, 2010-present. Neuropharmacology and psychiatry of Pavlovian-Instrumental transfer Dr. Martine van Schouwenburg, PhD Cognitive Neuroscience, Fronto-striatal mechanisms of attentional control current position: postdoctoral fellow at UC San Francisco, USA, (supervisor: prof. Adam Gazzaley) Ilse Thompson, MSc Neuroscience & Cognition, Utrecht University, Striatal GABA and glutamate in reversal learning Public Engagement & Media Public Engagement Leren van je fouten. Full-day workshop for psychiatric nursing staff, Psychiatrisch Centrum St. Amandus, Beernem, Belgium, March 2011 Brain Landing. Live real-time fmri experiment. DCCN Nijmegen & Paradiso Pop podium, Amsterdam, the Netherlands. March 2010 Learning from your mistakes. Lecture for Dutch final year secondary school students, Liemers College Zevenaar, Netherlands, 2009 How your brain tries to predict the world. Lecture for Dutch final year secondary school students, Lorenz College Arnhem, Netherlands, 2010 Can you see what I m thinking? Live real-time fmri experiment for children (age 8-12). NEMO science museum, Amsterdam, October 2009 Selected media coverage Radio: BBC - The Naked Scientists, BBC (2014): Print: The Guardian: In Praise of Uncertainty. (2013) De Telegraaf (Dutch newspaper, 2013). Online media: Psychology Today, Financial Post, PsychCentral, DailyNews, Medical Xpress, Alpha Galileo

7 Invited Talks 1. Affective Neuroscience and Pain Lab, National Center for Complementary and Integrative Health, National Institutes of Health, USA, September seminar 2. Max Planck Institute for Human Cognition, Leipzig, Germany, March Charité Hospital, Berlin, German, March Oxford University,Experimental Psychology Seminar Series, UK. October Danish Research Center for Magnetic Resonance, Global Excellence lecture, Hvidovre Hospital, Copenhagen, Denmark. October Technical University Madrid, Centre for Biomedical Technology, Madrid, Spain. September University College London, ICN seminar Series, Institute of Cognitive Neuroscience, UK, May Harvard Medical School, Department of Molecular & Cellular Biology, April Neuroimage Nord, Universitätsklinikum Hamburg-Eppendorf, Hamburg, Germany, April University of Groningen, Research Discussion Series, Department of Psychiatry, April Cornell University,Sackler Science series, Weil Medical College, September Aarhus University, Keynote lecture, Annual retreat, Mindlab, Denmark, August Rutgers University,Center for Molecular and Behavioural Neuroscience, USA, November University of Amsterdam, Amsterdam center for the study of adaptive control in brain and behavior, Netherlands, March University of Hamburg, Brown Bag seminar, NeuroImage Nord, Germany, Oxford University,FMRIB seminar series, Oxford, UK, January Cambridge University,Department of Psychology, UK, December Ecole Normale Superieure,Seminar series, Departement des Etudes Cognitives, France, October 2008 Conference Presentations 1. NVP Winter Conference, december 2015, Speaker planned symposium: The brain in control 2. Dutch Neuroscience Meeting, Lunteren, June 2015, symposium chair/organiser 3. Federation for European NeuroSciences annual conference, Milan, Italy, July 2014, Speaker 4. How cognitive neuroscience can guide therapy, Workshop at the Royal Netherlands Academy of Arts and Sciences, Netherlands, May 2013, symposium chair 5. Neuroplasticity symposium, Dopamine 2013, Sardinia, Italy, May Speaker 6. Neuroimaging in Psychiatry Symposium, University of Groningen, April 2013, Speaker 7. Workshop on Dynamic Causal Modelling, Brain & Spine Institute (ICM) Paris, France, August 2012, Speaker 8. Workshop on model-based cognitive neuroscience, University of Amsterdam, November 2012, Speaker 9. European Science Foundation Workshop on Attention, Motivation and Action, Copenhagen, August 2012, Speaker 10. Attention, Expectation and Awareness workshop, Columbia University, New York, USA, November 2011, Speaker

8 11. Symposium Verwrongen vooruitblik, schizofrenie als verstoring van de neurobiologische fundering van voorbewuste geestesprocessen. Psychiatric Center St Amandus, Beernem, Belgium, March 2011, Speaker 12. Annual meeting of Human Brain Mapping, Chicago, May 2009, Speaker 13. Schizophrenia Workshop, University College London, UK, March 2006, Speaker 14. EndoNeuroPsycho meeting, Doorwerth, The Netherlands, June 2006, Speaker 15. Touch, Blindness & neuroscience meeting, UNED, Madrid, Spain, October 2002, Speaker Professional Service Scientific reviewer Acta Psychologia, Biological Psychiatry, Brain, Cerebral Cortex, Cortex, Developmental Cognitive Neuroscience, Journal of Cognitive Neuroscience, Journal of Neuroscience, Molecular Psychiatry, NeuroImage, Neuron, Neuroscience and Biobehavioural Reviews, Psychological Science, Social Cognitive and Affective Neuroscience (SCAN), PLoS Computational Biology, PLoS ONE, Psychopharmacology, Wiley Interscience Reviews (WIRE) Review Editor Frontiers in Human Neuroscience