Verona, September 30 th -October 3 rd, 2007 Scientific Committee AINI Board AINP Board AIRIC Chairman

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1 XVII AINI Congress - Italian Association of NeuroImmunology XLIII AINP Congress Italian Association of NeuroPathology XXXIII AIRIC Congress Italian Association for Research on Brain Aging Scientific Committee AINI Board AINP Board AIRIC Chairman Verona, September 30 th -October 3 rd, 2007 Scientific Secretariat Prof. Bruno Bonetti Dipartimento di Scienze Neurologiche e della Visione Sezione di Neurologia Università di Verona P. Scuro, Verona Dr.ssa Gabriela Constantin Dipartimento di Patologia Sezione di Patologia Generale Università di Verona Strada le Grazie, Verona Prof. Alessandro Simonati Dipartimento di Scienze Neurologiche e della Visione Sezione di Neurologia Università di Verona P. Scuro, Verona Organising Secretariat Francesca Mariani EEM Congressi & Eventi Via Elio Lampridio Cerva, Roma

2 Invitation Cari Colleghi, siamo lieti di presentarvi il XVII Congresso dell Associazione Italiana di Neuroimmunologia che si terrà a Verona dal 30 Settembre al 3 Ottobre Il Congresso si svilupperà ricalcando lo schema consolidato degli ultimi eventi, con alcune novità che riteniamo interessanti dal punto di vista scientifico e culturale per tutti i partecipanti. La struttura portante del Congresso si articolerà in diverse Sessioni scientifiche che tratteranno le consuete tematiche neuroimmunologiche, sia in ambito clinico che sperimentale, avvalendosi anche della partecipazione di esperti internazionali: le problematiche dell autoimmunità nel sistema nervoso centrale, periferico e del muscolo, il ruolo di linfociti B e T nella risposta autoimmune, gli aspetti terapeutici nelle malattie neuroimmunologiche umane e sperimentali ed il contributo delle nuove tecnologie in tale ambito (systems biology e proteomica). Dal momento che negli stessi giorni a Verona si svolgeranno i Convegni nazionali della Società di Neuroscienze (SINS) e dell Associazione di Neuropatologia (AINP), abbiamo voluto cogliere l occasione per creare alcuni momenti di condivisione con tali eventi. A questo scopo, è stato organizzato un Simposio comune alle tre Società sul tema della Neuroinfiammazione che si terrà nella nostra giornata inaugurale; a seguire, vi sarà la lettura Sclerosi multipla: dalla neuropatologia alla neuroimmunologia pensata come trait d union dei partecipanti dell AINI e AINP. I due convegni proseguiranno poi in parallelo in maniera indipendente, ma con altri due eventi in comune: un simposio sull imaging in vivo del sistema nervoso centrale ed una sessione sulle malattie del nervo periferico. Vi aspettiamo numerosi a Verona nella speranza di avere colto le vostre esigenze e soddisfatto le vostre aspettative. Bruno Bonetti Gabriela Constantin

3 Congress venues: Sunday, September 30, 2007 Monday, Tuesday & Wednesday, October 1-2-3, 2007 Palazzo della Ragione Palazzo della Gran Guardia Piazza delle Erbe Piazza Brà Verona Verona Dates to remember: 27 August 2007 abstract submission deadline 27 August 2007 Travel Grant application deadline 3 September 2007 authors notification 10 September 2007 on-line registration deadline Updatings: Information about the congress and any change in the programme will be constantly updated at the AINI website Abstract submission: We invite you to submit an abstract no later than 27 August 2007 using the on-line facitilies which will be available on the congress website Abstract should be written in English and submitted on-line. If you have no access to the internet, please contact the Organising Secretariat. The Scientific Secretariat will accept abstracts on all topics related to Neuroimmunology. Oral communication: All abstracts selected as oral communication are in English and are allotted 10 minutes for presentation and 5 minutes for discussion. Power Point computer projection will be available for oral presentations. Poster session: A relevant area will be provided for the poster session. Posters should be 150 cm height and 100 cm wide and will remain on display for the whole duration of the meeting. Poster session requires the author s presence. Posters will be discussed preferably in English in the congress room on 1 October, from 14:30 to 16:00. Power point computer projection will be available for presentation, please bring a digital presentation with you. Travel Grants: A limited number of travel grants of 300 Euro will be awarded to students and young scientists under 32 years. The applicant should be AINI member and first author of a submitted abstract. Applicants should send a motivated letter to the Organsing Secretariat ( within 27 August 2007 together with a copy of their Curriculum Vitae and a letter signed by the head of department.

4 ECM accreditation: The Italian Commission for Continuous Medical Education assigned 16 credits to the congress. The credits will be assigned to all participants who will fulfill the questionnaire which will be distributed the last day of the meeting. Daily sign in will be also required. VII AINI Award Marco Vergelli The VII AINI award Marco Vergelli of Euro 750, will be assigned at the end of the congress to a student or young scientist under 35 years, whose scientific contribution, as an oral presentation, will be selected by a Scientific Committee composed by the AINI Board and the Organising Committee. IV AINI Award Domenico Paolini The IV AINI award Domenico Paolini of Euro 500, will be assigned at the end of the congress to a student or young scientist under 32 years, whose scientific contribution, as a poster presentation, will be selected by a Scientific Committee composed by the AINI Board and the Organising Committee. Registration fees: AINI member* Euro 240,00 Non AINI member Euro 300,00 *AINI member should be updated with the annual fee. The registration fee includes: participation to scientific sessions printed material of the congress certificate of attendance welcome reception coffee breaks buffet lunches social dinner VAT 20% included. To register, please use the on-line registration form which will be available in the website The deadline to register on-line is 10 September Payment in Euro can be made either by bank transfer, by cheque or by credit card. After that date, payments will be accepted only by credit card. Upon receipt of actual payment of the registration fee, each participant will receive a confirmation of registration. Refund of registration fees will be as follows: postmarked before 30 days of the meeting s date 100% refund minus Euro 25,00 handling fee; postmarked before 15 days of the meeting s date 50% refund; no refund for cancellations received after 15 September Any change of names will be allowed until 20 September 2007 free of charge. Social Programme: 30 September 2007 Welcome Reception 2 October 2007 Social Dinner

5 FINAL SCIENTIFIC PROGRAMME Sunday, 30 September 2007 Palazzo della Ragione Piazza delle Erbe 13:30 Registration Cangrande Room 14:30 17:00 Joint symposium of the Italian Associations of Neuroimmunology (AINI), Neuropathology (AINP) and Neuroscience (SINS) Neuroinflammation at the croassroad of neurosciences Chairs: M. Bentivoglio, N. Rizzuto, G. Martino 14:30 GL. Mancardi (Italy): Clinical features of Multiple Sclerosis and inflammatory demyelinating disorders of the central nervous system 15:15 M. Schwartz (Israel): Neuroinflammation and neurodegeneration 16:00 F. Aloisi (Italy): Mechanisms of chronic inflammation in the central nervous system 16:45 Welcome addresses Mastino Room 17:15 Plenary lecture (AINI+AINP+SINS) Chairs: A. Schenone, F. Aloisi C. Lucchinetti (USA): Multiple sclerosis: from neuropathology to neuroimmunology 18:30 Welcome party: Wine and cheese tasting

6 Sala Convegni Room Monday, 1 October 2007 Palazzo della Gran Guardia Piazza Brà 8:30-10:45 Session I: Immune regulation in nervous system diseases Chairs: G. Matarese, L. Battistini 8:30 Abstract 19 - Cytokine profile of CD4+Foxp3+ T cells in peripheral lymphoid organs and CNS during the course of relapsing EAE M. Esposito (Milan, Italy) 8:45 Abstract 45 - Phenotypical and functional characterization of Regulatory T cells in healthy individuals and in patients affected by Multiple Sclerosis disease with and without treatment D. Di Mitri (Rome, Italy) 9:00 Abstract 24 - Dopaminergic modulation of CD4+CD25+ regulatory T cells in multiple sclerosis patients: effect of interferon-beta M. Zaffaroni (Gallarate, VA, Italy) 9:15 Abstract 34 - Adipose-derived mesenchymal stem cells and CNS: differentiation potential and immune suppression S. Marconi (Verona, Italy) 9:30 Abstact 56 - Non cell-autonomous dysfunction of the endogenous brain stem cell compartment in mice with chronic brain inflammation S. Pluchino (Milan, Italy) 9:45 Abstract 53 - Leptin and regulatory T cells: a novel link between immune tolerance, metabolic state and autoimmunity V. De Rosa (Napoli, Italy) 10:00 V. Kuchroo (USA): TIM family in the regulation of autoimmune diseases 10:45-11:15 Coffee break Sala Convegni Room 11:15-13:15 Session II: Autoimmunity in PNS Joint Session Italian Association of Neuroimmunology and Neuropathology Chairs: N. Rizzuto, A. Uncini 11:15 B. Kieseier (Germany): Immune circuitry in the peripheral nervous system 11:45 R. Martini (Germany): Immunological aspects of inherited demyelination 12:15 S. Ferrari (Italy): Pathology of immune-mediated neuropathies 12:45 A. Quattrini (Italy): Clinical and pathological features of vasculitides associated with neuropathy

7 13:15-14:30 Lunch 14:30-16:00 Posters and coffee Chairs: G. Borsellino, D. Giunti, G. Ristori Sala Convegni Room 16:00-18:00 Symposium: In vivo imaging of the nervous system Joint Symposium Italian Association of Neuroimmunology and Neuropathology Chairs: A. Uccelli, A. Sbarbati 16:00 M. Kerschensteiner (Germany): In vivo imaging of axonal degeneration and regeneration 16:30 A. Flugel (Germany): Visualization of immune cells in inflammatory brain diseases 17:00 B. Stankoff (France): CNS damage by positron-emission tomography 17:30 P. Pinton (Italy): Intracellular signaling molecules in neurodegenerative diseases Sala Convegni Room 18:00-19:00 AINI General Assembly 19:30 AINI Soccer Venue

8 Sala Convegni Room Tuesday, 2 October 2007 Palazzo della Gran Guardia Piazza Brà 8:30-10:45 Session III: Autoimmunity in muscle Chairs: C. Antozzi, A. Evoli 8:30 Abstract 3 - Exploring the link between innate immunity and autoimmunity in myasthenia gravis: a study of TLR4-mediated pathways in thymic epithelial cells P. Cavalcante (Milan, Italy) 8:45 Abstract 8 - The involvement of the innate immune system in the pathophysiology of idiopathic inflammatory myopathies: a new insight C. Cappelletti (Milan, Italy) 9:00 Abstract 7 HLA allele frequency in MUSK-positive and ACHR-positive myasthenia gravis E. Bartoccioni (Rome, Italy) 9:15 Abstract 55 - Identification and characterization of immune-mediated myofibrillar myopathy M. Marini (Verona, Italy) 9:30 Abstract 32 - BDNF and its receptors are consistently expressed in human thymus: implications for cell fate in thymic physiology and myasthenia gravis-associated pathology A. Berzi (Milan, Italy) 9:45 Abstract 44 - T cell response to GM1 ganglioside in Guillain-Barré syndrome patients post-campylobacter jejuni infection M.T. Cencioni (Rome, Italy) 10:00 G. Vattemi (Italy): Immunobiology of muscle 10:45-11:15 Coffee break Sala Convegni Room 11:15-13:30 Session IV: Blood brain barrier and leukocyte migration Chairs: G. Constantin, S. Pluchino 11:15 R. Ransohoff (USA): Chemokines: Standing at the crossroads of immunobiology and neurobiology

9 12:00 Abstract 25 - Receptor-activity-modifying-protein (RAMP) 3 expression on Human T cells E. Liverani (Bristol, UK) 12:15 Abstract 50 - Role of Fucosyltransferase-VII and P-selectin glycoprotein ligand-1 in the migration of CD4+CD25+ regulatory T cells in inflamed brain S. Angiari (Verona, Italy) 12:30 Abstract 1 - Characterization of spleen and spinal cord infiltrating lymphocytes during actively induced EAE in Lewis rats R. Rigolio (Monza, Italy) 12:45 Abstract 12- Host/environment interactions in EAE: the adjuvant modulates differently CD4 and CD8 mediated responses to CNS antigens: clues to the role of environment in MS development F. Ria (Rome, Italy) 13:00 Abstract 2 - Histamine in immune regulation of the autoimmune response in experimental autoimmune encephalomyelitis M. Lapilla (Milan, Italy) 13:15 Abstract 49 - Critical role for leukocyte-endothelial adhesion mechanisms in epilepsy M. Martinello (Verona, Italy) 13:30-14:45 Lunch Sala Convegni Room 14:45-18:00 Session V: Immune mechanisms and intervention in nervous system diseases I Chairs: P. Muraro, R. Pedotti 14:45 D. Wraith (UK): Antigen-specific immunotherapy of autoimmune diseases 15:30 Abstract 57 - Neural stem cells restrain developing immunity and central nervous system damage via BMP-4-dependent ectopic niches in secondary lymphoid organs S. Pluchino (Milan, Italy) 15:45 Abstract 47 - Anti-inflammatory effects of calorie restriction on experimental autoimmune encephalomyelitis L. Piccio (St. Louis, USA)

10 16:00 Abstract 9 - Real time imaging of effector T cell activation within autoimmune CNS lesions after soluble antigen treatment F. Odoardi (Munich, Germany) 16:15 Abstract 48 - Mesenchymal Stem Cells ameliorate experimental ALS upon i.v. administration M.C. Principato (Genoa, Italy) 16:30-17:00 Cofee break 17:00 Abstract 23 - MSCs-DCs interactions: an intimate cell-cell contact A. Aldinucci (Florence, Italy) 17:15 Abstract 52 - Murine Mesenchymal Stem cell inhibit differentiation and functions of Bone Marrow Dendritic cells S. Chiesa (Genoa, Italy) 17:30 Abstract 4 IL17 and Multiple Sclerosis increased production in Clinically Isolated Syndrome A.P. Batocchi (Rome, Italy) 17:45 Abstract 26 - Multiple sclerosis in Sardinia: Reduced proportion of circulating plasmacytoid dendritic cells expressing BDCA-2 and BDCA-4 and reduced production of IL-6 and IL-10 by pdc in response to herpes simplex virus type 1 A. Sanna (Sassari, Italy) Sala Convegni Room 18:00-18:30 AINI Standardization Guidelines. Updating Chairs: F. Lolli, D. Franciotta

11 Sala Convegni Room Wednesday, 3 October 2007 Palazzo della Gran Guardia Piazza Brà 8:30-10:45 Session VI: Novel methodologies and data analysis Chairs: B. Bonetti, C. Laudanna 8:30 Abstract 10 - Nerve fiber layer analysis with OCT, SLP VCC and SCLO in patients with optic neuritis M. Suzani (Monza, Italy) 8:45 Abstract 13 - The expression of nine discriminating genes reverts to normal levels during pregnancy in patients with multiple sclerosis F. Gilli (Orbassano, TO, Italy) 9:00 Abstract 20 - Novel autoantigens recognized by CSF IgG from Hashimoto s encephalitis revealed by a proteomic approach B. Gini (Verona, Italy) 9:15 Abstract 22 - Carbon nanotubes impact on neurons and primary immune cells: an in vitro model T. Biagioli (Florence, Italy) 9:30 Abstract 46 - Role of NAADP-mediated Ca 2+ signalling in encephalitogenic CD4+ T cells C. Cordiglieri (Munich, Germany) 9:45 Abstract 21- Detection of Anti-Aquaporin4 antibodies by Western blot: a new tool for differential diagnosis in patients showing Neuromyelitis Optica M. Caldano (Orbassano, TO, Italy) 10:00 S. Baranzini (USA): Systems-based medicine approaches to understand and treat multiple sclerosis 10:45-11:15 Coffee break Sala Convegni Room 11:15-13:30 Session VII: Immune mechanisms and intervention in nervous system diseases II Chairs: S. Sotgiu, C. Avolio 11:15 P. Muraro (UK): Immuno-ablative therapies for neurological immune-mediated disorders 12:00 Abstract 37 - Regulatory CD56bright natural killer cells expanded during cyclophosphamide therapy in multiple sclerosis A. Laroni (Padova, Italy)

12 12:15 Abstract 42 - Glatiramer Acetate and Minocycline differently affect phenotype expression of blood derived dendritic cells in Multiple Sclerosis patients M. Ruggieri (Bari, Italy) 12:30 Abstract 35 - Relevance of NKRP1a+ CD8+ T cell subset in multiple sclerosis V. Annibali (Rome, Italy) 12:45 Abstract 29 - Reduced Toll-like receptor 9 expression in Multiple Sclerosis in response to P. falciparum A. Sanna (Sassari, Italy) 13:00 Abstract 31 - Immuno-mediated limbic encephalitis: clinical and immunological description of 15 patients R. Vitaliani (Treviso, Italy) 13:15-14:30 Lunch Sala Convegni Room 14:30-16:45 SessionVIII: Humoral immunity in nervous system diseases Chairs: D. Franciotta, R. Furlan 14:30 D. Lefranc (France): Proteomics and immunomics in multiple sclerosis 15:15 Abstract 17- Circulating levels of BAFF and APRIL in multiple sclerosis patients: results of a pilot study G. Cavaletti (Milano, Italy) 15:30 Abstract 30 - Transketolase and CNPase I isoforms are specifically recognized by IgG autoantibodies in multiple sclerosis patients L. Lovato (Verona, Italy) 15:45 Abstract 39 - Intrathecal IgM synthesis is associated with cortical lesions in multiple sclerosis patients L. Rinaldi (Padova, Italy) 16:00 Abstract 41 - Accumulation of Epstein-Barr virus-infected B-cells in the multiple sclerosis brain B. Serafini (Rome, Italy) 16:15 Abstract 43 - IgGs purified from RR-MS enhance demyelination in experimental autoimmune encephalomyelitis R. Pedotti (Milano, Italy) 16:30 Abstract 38- Trasverse myelitis and delayed VEP with positive NMO-IgG: Devic Syndrome? D. Travaglini (Chieti, Italy) 16:45 7th Marco Vergelli Award 17:00 4th Domenico Paolini Award 17:15 Closing remarks

13 POSTERS SESSION Monday, 1 October 2007 Abstract 5 - Increased expression of T-bet in circulating B cells of a patient with Multiple Sclerosis and celiac disease R. Iorio (Rome, Italy) Abstract 14 - Monophasic longitudinally extensive myelitis. A case report A.M. Musso (Verona, Italy) Abstract 18- Reversible paraneoplastic limbic encephalitis without antineural antibodies S. Ottaviani (Verona, Italy) Abstract 33 - Anti-neuropil antibodies in a patient with limbic encephalitis and breast cancer M. Zoccarato (Padova, Italy) Abstract 36 - Temporal epilepsy and psychosis with persistent oligoclonal bands and vanishing white matter lesion: atypical multiple sclerosis? D. Travaglini (Chieti, Italy) Abstract 11 T regulatory cells in the hyperplastic thymus associated with myasthenia gravis and their modulation by immunosuppressive therapy L. Peri (Rome, Italy) Abstract 54 - Complement-mediated necrotizing myopathy: clinical and pathological features of a specific idiopathic inflammatory myopathy F. Zappini (Verona, Italy) Abstract 16 - IFN-g/IL10 imbalance and altered FOXP3 induction in PBLS from MG patients following antigen-stimulation V. Nessi (Milan, Italy) Abstract 40 - Neural differentiation potential of human adipose-derived adult stem cells S. Marconi (Verona, Italy) Abstract 27 - Polymorphisms of the Chitotriosidase and clinical expression of multiple sclerosis G. Arru (Sassari, Italy) Abstract 28 - Multiple sclerosis-associated retrovirus and IFN therapy: a correlation study G. Arru (Sassari, Italy) Abstract 51 - Intracisternal administration of MSC does not provide clinical advantage in comparison of intravenous injection S. Morando (Genoa, Italy) Abstract 15 - Interferon-a/b receptor (IFNAR) Gene Expression has a prognostic value for NABs Development in patients treated with interferon-b P. Valentino (Orbassano, TO, Italy)

14 Abstract 58 Clinical usefilness of NMO-IgG in the diagnosis of Neuromyelitis Optica S. Matà (Firenze, Italy) Abstract 59 CNS human herpes virus-6 infection in immunocompetent adult patients S. Matà (Firenze, Italy) Abstract 60 Dramatic improvement of follicular non-hodgkin s neurolypphomatosis after rituximab therapy M. Lucchetta (Padova, Italy) Abstract 61 Neuromyotonia associated with myasthenia gravis occurring after thymectomy for malignant thymic carcinoma F. Grassivaro (Padova, Italy)

15 Accommodation: EEM Congressi has been appointed the official agency for the Congress and will be offering special reduced rates for hotel accommodation. Rooms have been booked in several hotels in the city centre. All hotels are within walking distance of the Congress venues. Reservations should be made through EEM Congressi using the on-line Registration and Accommodation form. Hotel reservation deadline will be 10 September Rooms will be assigned on a first-come, first-served basis. AINI Members* Non members Hotel SGL DUS DBL SGL DUS DBL Distance from Gran Guardia Giberti**** 115,00 130,00 145,00 145,00 160,00 175, meters Accademia**** 86,00 118,00 130,00 116,00 148,00 160, meters San Luca**** n/d 120,00 130,00 n/d 150,00 160, meters Firenze**** n/d 92,00 116,00 n/d 122,00 146, meters Europa*** n/d 85,00 95,00 n/d 115,00 125, meters Mastino*** n/d 90,00 100,00 n/d 120,00 130, meters De Capuleti*** n/d 95,00 100,00 n/d 125,00 130, meters legend: SGL: single room DUS: double room for single use DBL: double room Rates shown are in Euro, per room, per night and inclusive of breakfast, services and VAT of 10%. *AINI members should be updated with the annual fee. Reservations: Upon receiving your request, together with the actual full payment of hotel accommodation, EEM will assign a room in the chosen hotel upon availability and send a confirmation indicating all hotel details, as well as arrival and departure dates and type of room. Payment: Full payment is required upon reservation. Payments by bank transfer, cheque or credit card will be accepted for all accommodation requests received within 10 September After that date, payments can be made only by credit card. Please also complete the on-line form with your invoicing details to allow EEM to issue and send you the relevant invoice for hotel accommodation and registration fee. Changes & cancellations: Cancellations will be subject to a penalty which will be calculated on the total hotel accommodation amount as follows: postmarked before 60 days of the congress date 30% postmarked before 17 days of the congress date 60% postmarked after 17 days of the congress date and for no-show 100% Changes should be made in writing to EEM. Please do not contact the hotel directly. Any change of names will be allowed until 20 September 2007 free of charge.

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