55 th. Catanzaro September Xxxxxxxxxxxxxxxx. : understanding onc-omics for patient-tailored cancer therapy.

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1 Xxxxxxxxxxxxxxxx 55 th ABSTRACT SUBMISSION DEADLINE June 7,

2 Committee CONGRESS VENUE Università degli Studi Magna Græcia di Viale Europa Germaneto - Villaggio Guglielmo Congress Center Piazza Susanna, Copanello - ORGANIZING SECRETARIAT Adria Congrex Srl Via Sassonia, Rimini RN Ph Fax Web site SIC SECRETARIAT Società Italiana di Cancerologia Via G. Venezian, Milan Ph Fax Web site SIC SCIENTIFIC BOARD President Riccardo Dolcetti (CRO-IRCCS, National Cancer Institute, Aviano, Pordenone, Italy) President Elect Silvia Giordano (Institute for Cancer Research and Treatment, University of Turin, Candiolo, Italy) Board Anna Bagnato (Regina Elena National Cancer Institute, Rome, Italy) Vincenzo Bronte (University of Verona, Italy) Maurizio D Incalci ( Mario Negri Institute for Pharmacological Research, Milan, Italy) Nicola Normanno (National Cancer Institute G. Pascale, Naples, Italy) Salvatore Pece (IFOM-IEO Campus, University of Milan, Italy) Katia Scotlandi (Orthopaedic Rizzoli Institute, Bologna, Italy) Gabriella Sozzi (IRCCS National Cancer Institute, Milan, Italy) Stefania Tommasi (National Cancer Centre Giovanni Paolo II, Bari, Italy) Giuseppe Viglietto (University of Magna Græcia,, Italy) Past President Alfredo Fusco ( Federico II University, Naples, Italy) Representative for Young Researchers Chiara Gabellini (Regina Elena National Cancer Institute, Rome, Italy) Pierlorenzo Pallante (Institute of Endocrinology and Experimental Oncology, CNR, Naples, Italy) SCIENTIFIC AND ORGANIZING COMMITTEE Scientific Coordinator Giuseppe Viglietto (University of Magna Graecia,, Italy) Local Scientific Committee Gennaro Ciliberto (National Cancer Institute G. Pascale, Naples, Italy; University of Magna Græcia,, Italy) Francesco Saverio Costanzo (University of Magna Graecia,, Italy) Gianni Cuda (University of Magna Græcia,, Italy) Dolores Di Vizio (Cedars Sinai Medical Center, Los Angeles, CA, USA) Marcello Maggiolini (University of Cosenza, Italy) Giovanni Morrone (University of Magna Græcia,, Italy) Pierosandro Tagliaferri (University of Magna Græcia,, Italy) Pierfrancesco Tassone (University of Magna Græcia,, Italy) 2 3

3 Speakers Monday 23 September VENUE UNIVERSITY OF CATANZARO, AUDITORIUM Paolo Ascierto National Cancer Institute G. Pascale, Naples, Italy Rosa Bernardi IRCCS San Raffaele Hospital, Milan, Italy Renzo Canetta Bristol-Myers Squibb, Wallingford, CT, USA Ugo Cavallaro European Institute of Oncology, Milan, Italy Paola Chiarugi University of Florence, Italy Francesca Demichelis University of Trento, Italy Federica Di Nicolantonio Institute for Cancer Research and Treatment, Candiolo, Turin, Italy Giulio Draetta MD Anderson Cancer Center, Houston, TX, USA Riccardo Fodde Josephine Nefkens Institute Erasmus University Medical Centre, Rotterdam, The Netherlands Niels Frandsen Exiqon, Vedbaek, Denmark Guido Franzoso Imperial College, London, United Kingdom Eric Holland Memorial Sloan Kettering Cancer Center, New York, NY, USA Antonio Iavarone Columbia University, New York, NY, USA Norman J. Maitland University of York, United Kingdom Francesco Marincola National Institutes of Health, Bethesda, MD, USA Maria Caterina Mione Karlsruhe Institute of Technology, Eggenstein-Leopoldshafen, Germany Paolo Paoletti GlaxoSmithKline, Collegeville, PA, USA Giorgio Parmiani IRCCS San Raffaele Hospital, Milan, Italy Daniel Peeper The Netherlands Cancer Institute, Amsterdam, The Netherlands John Quackenbush Dana-Farber Cancer Institute, Boston, MA, USA Lucia Ricci Vitiani ISS, Istituto Superiore di Sanità, Rome, Italy Mercedes Robledo Spanish National Cancer Centre (CNIO), Madrid, Spain Mark A. Rubin Weill Cornel Medical College, New York, NY, USA Massimo Santoro University of Naples, Italy Aldo Scarpa University of Verona, Italy Jean J. Schuringa Faculty of Medical Sciences, Hematology, Groningen, The Netherlands Salvatore Siena Niguarda Ca Granda Hospital, Milan, Italy Frank J. Slack Yale University, New Haven, CT, USA Gabriella Sozzi IRCCS National Cancer Institute, Milan, Italy Henk J. Stunnemberg Nijmegen Centre for Molecular Life Sciences, Nijmegen, The Netherlands Andreas Trumpp Heidelberg Institute for Stem Cell Technology and Experimental Medicine, Heidelberg, Germany Stefano Volinia University of Ferrara, Italy OPENING CEREMONY A. Quattrone (Magnifico Rettore Magna Graecia University,, Italy) R. Dolcetti (SIC President, Aviano PN, Italy) OPENING LECTURE Function-based screening for therapeutic targets in cancer D. Peeper (Amsterdam, The Netherlands) Sponsored by EACR NON CODING RNAS MicroRNAs as targeted therapeutics and therapeutic targets in cancer F.J. Slack (New Haven, USA) MicroRNA and lung cancer G. Sozzi (Milan, Italy) Role of MicroRNAs in progression and invasiveness of breast cancer S. Volinia (Ferrara, Italy) Selected presentations CANCER BIOCHEMISTRY AND METABOLISM Cancer-selected targeting of the NF-ĸB pathway G. Franzoso (London, UK) Reciprocal metabolic deregulation of tumors and their stroma P. Chiarugi (Florence, Italy) Selected presentations WELCOME COCKTAIL Shuttle Bus from the University to Villaggio Gugliemo 4 5

4 Tuesday 24 September VENUE VILLAGGIO GUGLIELMO Tuesday 24 September VENUE VILLAGGIO GUGLIELMO MEET THE EXPERT INFORMAL ROUND Parallel Sessions ANIMAL MODELS E. Holland (New York, USA) - M. Mione (Eggenstein-Leopoldshafen, Germany) CANCER STEM CELLS N. Maitland (York, United Kingdom) - R. Fodde (Rotterdam, The Netherlands) CANCER GENOMICS AND EPIGENOMICS The drivers of oncogenesis and master regulators of glioblastoma A. Iavarone (New York, USA) Next generation histopathological diagnosis from genomics to clinical application A. Scarpa (Verona, Italy) From OMIC to the patient M. Robledo (Madrid, Spain) Epigenomics functionally indexing genomes in health and disease H. Stunnemberg (Nijmegen, The Netherlands) Coffee Break Molecular archeology from next generation explorations F. Demichelis (Trento, Italy) Detection of genetic and epigenetic alterations in plasma circulating tumor DNA F. Di Nicolantonio (Turin, Italy) Selected presentations Lunch POSTER VIEWING ADVANCED DIAGNOSTICS AND THERAPEUTICS THE PHARMA S VIEW Functional validation of cancer genes G. Draetta (Houston, USA) LNA antisense oligonucleotides promising drug development platform and antisense tools for the study of RNA function in animals N. Frandsen (Exiqon, Vedbaek, Denmark) Challenges of drug discovery and development in the era of precision medicine P. Paoletti (GSK, Collegeville, USA) Immuno oncology as a new modality of cancer treatment research and development R. Canetta (BMS, Wallingford, USA) Coffee Break THE CLINICIANS VIEW Joint Meeting SIC-AIOM Targeted drugs for melanoma P. Ascierto (Naples, Italy) Targeted drugs for colon carcinoma S. Siena (Milan, Italy) Combined immuno and chemotherapeutic strategies G. Parmiani (Milan, Italy) Sponsored by EACR Applications of OMIC approaches to cancer F. Marincola (Bethesda, USA) MEETING OF SIC YOUNG INVESTIGATORS 6 7

5 Wednesday 25 September VENUE VILLAGGIO GUGLIELMO Thursday 26 September VENUE VILLAGGIO GUGLIELMO MEET THE EXPERT INFORMAL ROUND Parallel Sessions Cancer Genomics A. Iavarone (New York, USA) - M.A. Rubin (New York, USA) Non Coding RNAs F.J. Slack (New Haven, USA ) Oncometabolics P. Chiarugi (Florence, Italy) POSTER DISCUSSION 1 Parallel Sessions Poster Discussion A Poster Discussion B GIORGIO PRODI LECTURE From RET oncogene identification in thyroid cancer to targeted therapy M. Santoro (Naples, Italy) POSTER VIEWING Lunch POSTER DISCUSSION 2 Parallel Sessions Poster Discussion A Poster Discussion B CANCER STEM CELLS The importance of asymmetry for gene expression in the stem cell compartment of human prostate epithelium N.J. Maitland (York, United Kingdom) Sponsored by EACR Stem cells in homeostasis and cancer the good, the bad and the ugly R. Fodde (Rotterdam, The Netherlands) Clinical implications of cancer stem cell hypothesis L. Ricci-Vitiani (Rome, Italy) ANIMAL MODELS OF CANCER Title to be defined E. Holland (New York, USA) Circulating metastasis-initiating cells in breast cancer A. Trumpp (Heidelberg, Germany) The role of hypoxic responses in leukemogenesis R. Bernardi (Milan, Italy) Novel players in tumor microenvironment U. Cavallaro (Milan, Italy) Coffee Break Application of genomics to zebrafish models in cancer research M.A. Rubin (New York, USA) Zebrafish models of cancer M.C. Mione (Eggenstein-Leopoldshafen, Germany) Selected presentations CLOSING LECTURE J. Quackenbush (Boston, USA) AWARD FOR THE BEST ORAL SELECTED PRESENTATION CLOSING REMARKS Lunch Modeling of human leukemias J.J. Schuringa (Groningen, The Netherlands) Selected presentations AWARD CEREMONY SIC GENERAL ASSEMBLY SOCIAL DINNER 8 9

6 Scientific Information Scientific Information CME Credits The scientifi c programme of the 55 th has been submitted for the accreditation by the Italian Ministry of Health. Credits have been requested for the following categories - Medical Surgeon (Haematology, Medical Genetics, Oncology, Pathological Anatomy, Pharmacology and Clinical Toxicology, Clinical Pathology, Internal Medicine) - Biologist, Pharmacist, Chemist (Analytical Chemistry), Physicist (Health Physics), Veterinary Surgeon Abstract submission The organizers invite authors to submit abstracts for consideration and inclusion in the programme. Abstracts must be sent by June and must focus on the following topics Autophagy, apoptosis, necrosis and senescence Cancer genetic Cancer modeling and imaging Cancer stem cells Cell adhesion, migration, invasion and metastasis Cell metabolism and cell cycle regulation Control of gene expression and epigenetics DNA damage and molecular responses to damage Drug resistance Infectious agents and cancer Innovative therapeutic Molecular epidemiology and chemoprevention Molecular markers of diagnosis, prognosis and response to therapy Animal models of cancer Nanotechnology Signal transduction and intracellular trafficking System biology and emerging technologies Targeted therapy Tumor immunology and immunotherapy Tumor microenvironment inflammation, hypoxia and angiogenesis Abstracts must be written in English and must not exceed characters (including blanks). All submitted abstracts will be reviewed by a Scientifi c Committee and selected for oral or poster presentations (sizes cm 70x100h.). PRIZES Piero Trivella and EACR Prizes to the best posters The Associazione Oncologica Pisana Prof. Piero Trivella and the European Association for Cancer Research (EACR) will award the best posters. To apply for poster prizes it is necessary to Be SIC Member Be first author of the submitted abstract (copy of the abstract must be attached) Be younger than 35 years at the date of the Meeting (copy of the identity card must be attached) Be regularly registered in the Meeting Those who wish to apply for the prize must present their poster at the Meeting even in case their abstract has been selected as oral presentation. Should the winner not be present at the Award Ceremony, the prize will be awarded following the ranking order. The application must be sent by June 14, Travel Grants A limited number of Travel Grants can be awarded upon financial availability. To apply for Travel Grants it is necessary to Be SIC Member Be first author of the submitted abstract (copy of the abstract must be attached) Be younger than 35 years at the date of the Meeting (copy of the identity card must be attached) Be regularly registered in the Meeting Attach the Curriculum Vitae including a list of all publications The application must be sent by June 14, Elena Cappannini Prize to the best 2012 publication as first author in innovative approaches for cancer treatments To apply for this prize in memory of Elena Cappannini it is necessary to Be first author of the publication in the field of preclinical or clinical innovative approaches for cancer treatment published in 2012 (copy of the paper and CV must be attached) Be younger than 40 years at the date of the Meeting (copy of the identity card must be attached) The application must be sent by June 14, All applications are available on the SIC website and must be sent to the SIC Secretariat via All prizes will be awarded, on the basis of a merit ranking, on September 25, during the Award Ceremony. Abstracts must be sent using the online form. Abstracts sent in any other way will not be accepted. Notifi cation of acceptance or rejection, together with information about session, date, time and type of presentation, will follow. Each Author can present only one abstract. Abstracts will be included in the Programme and in the Abstract book only if the Presenting Author will be regularly registered in the Congress

7 General Information Registration Information Dates, 23 26, September 2013 Congress Venue September 23 Università degli Studi Magna Græcia di Viale Europa Germaneto September Villaggio Guglielmo Congress Center Piazza Susanna, Copanello - SIC Secretariat Società Italiana di Cancerologia Via G. Venezian, Milan Ph Fax Web site Organizing Secretariat Adria Congrex Srl Via Sassonia, Rimini RN Ph Fax Web site Language The offi cial language of the Meeting is English. Simultaneous translation will not be provided. Badges Participants are kindly requested to wear their badge throughout the Meeting. Certificates of Attendance Certifi cate of attendance is issued on request to all registered participants at the end of the Meeting. Exhibition and Sponsorship A technical, pharmaceutical and publication exhibition will take place in the Meeting Venue throughout the scientifi c works. Additional sponsoring opportunities are available. For any information, please contact the Organizing Secretariat Adria Congrex. Registration Fees Early registration Late registration on-site registration by July 7 by September 9 SIC MEMBER (*) 355,00 410,00 450,00 NON SIC MEMBER (**) 455,00 510,00 550,00 SIC MEMBER UNDER 35 (*) 210,00 260,00 280,00 NON SIC MEMBER UNDER 35 (**) 270,00 330,00 355,00 (*)VAT non applicable as for law ex Art.4 DPR 633/72; (**) VAT 21% included The VAT rate will be applied depending on the Italian fiscal law at the time of payment. Registration fees include admission to the scientific sessions admission to the exhibition area name badge and congress kit abstracts book attendance certificate ECM certificate welcome cocktail, coffee breaks, light lunches and social dinner Registrations can be requested submitting the registration form online. Participants can also download a PDF file, fill it in and send it by mail or fax to the Organizing Secretariat AdriaCongrex Fax Registrations without payment will not be accepted. Payment Methods and Details Payment should be made by one of the following methods Bank transfer Please transfer the payment to Adria Congrex Bank details IT 18 N CC The payment transfer form should clearly state SIC 2013 Code VACH and the name(s) of the delegate(s). Credit card All major credit cards are accepted (American Express, VISA, Mastercard, Cartasi). REGISTRATIONS WILL BE PROCESSED ONLY WHEN ACCOMPANIED BY THE TOTAL PAYMENT. Cancellation In case of cancellation reimbursement will not be done

8 Registration Information Registration Information Insurance Registration fee does not include insurance of any kind. The Congress Organizers will not be responsible for any participant failing or damages. Any type of insurance should be purchased by congress participants on their own. Official housing bureau and travel agency For information and/or reservation please contact the Offi cial Housing Bureau and Travel Agency of the Meeting Via Sassonia, Rimini - Ph Fax The Organizing Secretariat provides rooms at the conference venue,villaggio Guglielmo. Reservations can be requested submitting the online registration form available on the website Reservations must be sent by September 3, After this deadline rates and availability will not be guaranteed. Rooms will be allocated on a fi rst come fi rst served basis. Hotel rates are intended per person, per day and include vat (city tax not included). Reservations can be requested submitting the hotel accommodation form online or downloading the PDF form, (in this case, the PDF form can be sent by mail or fax to the Organizing Secretariat, Adria Congrex, Fax ). Reservations without deposit will not be processed Hotel Accommodation at Villaggio Guglielmo Treatment Dus - Double use for single use Twin Room Three bed in a Room Half Board with dinner 78,00 60,00 54,00 B&B 65,00 50,00 45,00 Special Packages (transfer service included) A) Double use for single use euro 228,00 B) Twin room/double room euro 180,00 per person C) Three bed room euro 164,00 per person The special Packages include - n. 2 overnights on Bed&Breakfast treatment at Villaggio Guglielmo (on Sept 23rd and Sept 25th, 2013) - n. 1 overnight on Half Board treatment at Villaggio Guglielmo (on Sept 24th, 2013) - transfer from Lamezia Terme** (airport or railway station) on Sept 23rd, transfer from Villaggio Guglielmo to Lamezia Terme** (airport or railway station) on Sept 26th - vat **Lamezia Terme is 50 Km far from Villaggio Guglielmo. City Tax euro 2,00 per person, per day. City tax will be paid directly to the hotel at the check out. Transfer service People who don t book special packages, can require the transfer from Lamezia Terme airport or railway station and viceversa, sending an to railways and viceversa, sending an to it writing all the details (date, timetable, number of person)

9 IMPORTANT DATES Deadline for abstract submission June 7, 2013 Deadline for application for Piero Trivella and EACR Prizes to the best posters June 14, 2013 Deadline for application for Travel Grants June 14, 2013 Deadline for application for the Prize Elena Cappannini June 14, 2013 Deadline for early registration fees July 7, 2013 Deadline for hotel accommodation September 3, 2013 Deadline for late registration fees September 9, 2013 For abstracts submission, registrations and hotel accommodation please visit

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