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1 Europass Curriculum Vitae Personal information First name(s) / Surname(s) CESSELLI Daniela Nationality Italian Date of birth Education and training Date 1989 Title of qualification awarded Secondary school with an emphasis on sciences Name and type of organisation providing education and training Liceo Scientifico M. Grigoletti Via delle Fontane Pordenone Date 1998 Title of qualification awarded MD degree Name and type of organisation providing education and training University of Udine Faculty of Medicine Degree grade: 110/110 with honors The thesis, entitled Study of the expression of the transcription factor Paxin normal and pathological thyroid tissue has been published. Date 2002 Title of qualification awarded Specialization in medical Oncology Degree grade: 70/70 with honors The thesis has been published. Name and type of organisation providing education and training University of Udine Faculty of Medicine School of specialization in Medical Oncology Director: Prof. C.A. Beltrami Date 2006 Title of qualification awarded PhD Name and type of organisation providing education and training University of Siena Faculty of Medicine PhD program in Quantitative and molecular diagnostic pathology - XVIII ciclo Director: Prof. L. Leoncini The PhD thesis, entitled Isolation, growth and characterization of human pluripotent mesenchymal stem cells has been published. Page 1/12 - Curriculum vitae of 11

2 Name and type of organisation providing education and training Date May 2010 Registration to the Medical School for the Specialization in Pathology University of Udine Faculty of Medicine School of specialization in Medical Oncology Director: Prof. C.A. Beltrami Research Activity Dates June Occupation or position held Associate Researcher Main activities and Name and address of employer Coordination of a research group within the European Grant, 7FP, Ideas, ERC Advanced Grant Molecular Nanotechnology For Life Science Application: QUantitative Interactomics for Diagnostics, Proteomics and QUantitative Oncology,(Quidroquo) proposal n P.I. Prof. G. Scoles University of Udine DSMB P.le S.Maria della Misericordia, Udine Dates July Occupation or position held Principal investigator of the project: Employment of Adipose tissue derived Multipotent Adult Stem Cells for cardiovascular regeneration Main activities and Name and address of employer Coordination of a research group of young scientists CIME Azienda Ospedaliero-Universitaria of Udine P.le S.Maria della Misericordia Udine Dates 6/3/2010-2/4/2010 Occupation or position held Visiting scientist Main activities and Collaboration on a project focused on cardiac stem cell senescence Name and address of employerprof. P. Anversa Department of Anesthesia Brigham and Women's Hospital Boston, MA Dates 15/2/ /2/2009 Occupation or position held Visiting scientist Main activities and Collaboration on a project focused on cardiac stem cell senescence Name and address of employerprof. P. Anversa Department of Anesthesia Brigham and Women's Hospital Boston, MA Dates December 2006 May 2010 Occupation or position held Research scientist Page 2/12 - Curriculum vitae of 22

3 Main activities and Name and address of employer Organization and coordination of a research group focused on the study human gliomas. CIME Azienda Ospedaliero-Universitaria of Udine P.le S.Maria della Misericordia Udine Type of activity Isolation, characterization and proteomic analysis of stem cells isolated from human gliomas. Occupation or position held Main activities and Name and address of employer Type of activity Dates January 2003 December 2008 Research activity in the Institute of Pathology held by Prof. C.A. Beltrami Organization and coordination of a research group together with Dr A. Beltrami. DIRM University of Udine P.le S.Maria della Misericordia Udine 1. Isolation and characterization of multipotent adult stem cells from several human tissues. 2. Use of stem cells in cardiac, hepatic and neural regenerative medicine. 3. Stem cells in human ovarian, liver and brain cancer. Dates January 2000 January 2003 Occupation or position held Research Fellow Name and address of employer Main activities and Publication in scientific journals Prof. P. Anversa Cardiovascular Research Institute New York Medical College Valhalla. NY (USA) 1. Study of the effects of hyperglycemia and oxidative stress on myocyte death and heart failure. 2. Identification and characterization of cardiac stem cell niches in a normal murine model. 3. Evaluation, by long term BrdU labeling assay, of the cardiac myocyt turnover in young healthy mouse. PAPERS in international peer-reviewed journals Beltrami AP, Cesselli D, Beltrami CA (2012) Cardiac Resident Stem Cells Work (Still) in Progress. J Stem Cell Res Ther S9:001. doi: / s9-001 Magini A, Polchi A, Urbanelli L, et al. TFEB activation promotes the recruitment of lysosomal glycohydrolases β-hexosaminidase and β- galactosidase to the plasma membrane. Biochemical and Biophysical Research Communications Cesselli D, D'Aurizio F, Marcon P, Bergamin N, Beltrami CA, et al. (2013) Cardiac stem cell senescence. Methods Mol Biol 976: Zeppieri M, Salvetat ML, Beltrami AP, Cesselli D, Bergamin N, et al. (2013) Human adipose-derived stem cells for the treatment of chemically burned rat cornea: preliminary results. Curr Eye Res 38: Garrovo C, Bergamin N, Bates D, Cesselli D, Beltrami AP, et al. (2013) vivo tracking of murine adipose tissue-derived multipotent adult stem cells and ex vivo cross-validation. Int J Mol Imaging 2013: Bergamin N, Dardis A, Beltrami A, Cesselli D, Rigo S, et al. (2013) Page 3/12 - Curriculum vitae of 33

4 Page 4/12 - Curriculum vitae of human neuronal model of Niemann Pick C disease developed from stem cells isolated from patient's skin. Orphanet J Rare Dis 8: 34. Katare R, Oikawa A, Cesselli D, et al. Boosting the pentose phosphat pathway restores cardiac progenitor cell availability in diabete Cardiovasc Res Ferro F, Spelat R, D'Aurizio F, et al. Dental pulp stem cells differentiatio reveals new insights in Oct4A dynamics. PLoS One 2012; 7: e Ferro F, Spelat R, D'Aurizio F, et al. Acellular bone colonization an aggregate culture conditions diversely influence murine periosteum mesenchymal stem cell differentiation potential in long-term in vitr osteoinductive conditions. Tissue Eng Part A 2012; 18: Beltrami AP, Cesselli D, Beltrami CA. Stem cell senescence an regenerative paradigms. Clin Pharmacol Ther 2012; 91: Amadesi S, Reni C, Katare R, et al. Role for substance p-base nociceptive signaling in progenitor cell activation and angiogenes during ischemia in mice and in human subjects. Circulation 2012; , S1-19. Katare R, Riu F, Mitchell K, et al. Transplantation of Human Pericyt Progenitor Cells Improves the Repair of Infarcted Heart Throug Activation of an Angiogenic Program Involving Micro-RNA-132. Circ Re Katare R, Caporali A, Zentilin L, et al. Intravenous gene therapy with PIM 1 via a cardiotropic viral vector halts the progression of diabet cardiomyopathy through promotion of prosurvival signaling. Circ Re 2011; 108: Fortini C, Toffoletto B, Fucili A, et al. Circulating stem cell vary with NYH stage in heart failure patients. J Cell Mol Med 2011; 15: Ferro F, Spelat R, Falini G, et al. Adipose tissue-derived stem cell in vitr differentiation in a three-dimensional dental bud structure. Am J Path 2011; 178: Cesselli D, Beltrami AP, Poz A, et al. Role of tumor associated fibroblas in human liver regeneration, cirrhosis, and cancer. Int J Hepatol : Cesselli D, Beltrami AP, D'Aurizio F, et al. Effects of age and heart failur on human cardiac stem cell function. Am J Pathol 2011; 179: Beltrami AP, Cesselli D, Beltrami CA. At the stem of youth and health Pharmacol Ther 2011; 129: Kajstura J, Gurusamy N, Ogorek B, et al. Myocyte Turnover in the Agin Human Heart. Circ Res Ferro F, Falini G, Spelat R, et al. Biochemical and biophysical analysis o tissue engineered bone obtained from 3D culture of a subset of bon marrow mesenchymal stem cells. Tissue Eng Part A Corallini F, Secchiero P, Beltrami AP, et al. TNF-alpha modulates th migratory response of mesenchymal stem cells to TRAIL. Cell Mol Life S Campagnolo P, Cesselli D, Al Haj Zen A, et al. Human Adult Ven Saphena Contains Perivascular Progenitor Cells Endowed Wit Clonogenic and Proangiogenic Potential. Circulation Kostic I, Toffoletto B, Fontanini E, et al. Influence of iodide excess an interferon-gamma on human primary thyroid cell proliferatio thyroglobulin secretion, and intracellular adhesion molecule-1 an human leukocyte antigen-dr expression. Thyroid 2009; 19: Cesselli D, Beltrami AP, Rigo S, et al. Multipotent progenitor cells ar present in human peripheral blood. Circ Res 2009; 104: Biagioli M, Pinto M, Cesselli D, et al. Unexpected expression of alpha and beta-globin in mesencephalic dopaminergic neurons and glial cell 44

5 Proc Natl Acad Sci U S A 2009; 106: Beltrami AP, Cesselli D, Beltrami CA. Pluripotency rush! Molecular cue for pluripotency, genetic reprogramming of adult stem cells, and wide multipotent adult cells. Pharmacol Ther 2009; 124: Secchiero P, Melloni E, Corallini F, et al. Tumor necrosis factor-relate apoptosis-inducing ligand promotes migration of human bone marro multipotent stromal cells. Stem Cells 2008; 26: Beltrami AP, Cesselli D, Bergamin N, et al. Multipotent cells can b generated in vitro from several adult human organs (heart, liver, an bone marrow). Blood 2007; 110: Urbanek K, Cesselli D, Rota M, et al. Stem cell niches in the adult mous heart. Proc Natl Acad Sci U S A 2006; 103: Muller P, Beltrami AP, Cesselli D, Pfeiffer P, Kazakov A, Bohm M Myocardial regeneration by endogenous adult progenitor cells. J Mol Ce Cardiol 2005; 39: Beltrami AP, Cesselli D, Bergamin N, et al. Investigation on possible ce sources to be utilized for cardiac cell therapy. Pathologica 2005; 97: 185 Fiordaliso F, Leri A, Cesselli D, et al. Hyperglycemia activates p53 an p53-regulated genes leading to myocyte cell death. Diabetes 2001; Cesselli D, Jakoniuk I, Barlucchi L, et al. Oxidative stress-mediate cardiac cell death is a major determinant of ventricular dysfunction an failure in dog dilated cardiomyopathy. Circ Res 2001; 89: Tell G, Pellizzari L, Pucillo C, et al. TSH controls Ref-1 nuclea translocation in thyroid cells. J Mol Endocrinol 2000; 24: Puglisi F, Cesselli D, Damante G, Pellizzari L, Beltrami CA, Di Loreto C Expression of Pax-8, p53 and bcl-2 in human benign and malignan thyroid diseases. Anticancer Res 2000; 20: CHAPTER in peer-reviwed books Cesselli D, Caragnano A, Bergamin N, Zanon V, Finato N, Beltrami CA Beltrami AP. Pharmacologic Inhibition of Cardiac Stem Cell Senescenc In: Nagata T, ed. Senescence. Japan: INTECH; ISBN Accepted manuscript. Beltrami AP, Cesselli D, Beltrami CA. Multiple Sources for Cardiac Stem Cells and Their Cardiogenic Potential. Regenerating the Heart. In: Cohe IS, Gaudette GR, eds. Regenerating the Heart: Humana Press; 2011: ISBN DOI / _10. Cesselli D, D Aurizio F, Marcon P, Bergamin N, Beltrami CA, and Beltram AP. Cardiac Stem Cell Senescence. In: Stem Cells and Aging. Ne York:Springer - Humana press, ISBN: In press Cesselli D, Beltrami AP, Pucer A, Bourkoula E, Ius T, Vindigni M, Skrap M Beltrami CA (in stampa). Human Low Grade Glioma Cultures. In: Diffus Low-Grade Gliomas in Adults. Springer, ISBN: press ABSTRACTs presented at international scientific meeting or published in peer reviewed yournals Katare R, Oikawa A, Riu F, Beltrami AP, Cesselli D, Emanueli C, Madeddu P (2012). Diabetes induces maladaptive autophagy in cardiomyocytes and resident cardiac stem cells. CARDIOVASCULAR RESEARCH, vol. 93, ISSN: Meloni M., Caporali A., Cesselli D, Fortunato O., Avolio E., Madeddu Page 5/12 - Curriculum vitae of 55

6 Page 6/12 - Curriculum vitae of P., Beltrami A. P., Emanueli C. (2012). Effects of cardiac nerve growth factor overexpression on bone marrow and peripheral blood progenitor cells after myocardial infarction. CARDIOVASCULAR RESEARCH, vol. 93, p. S98, ISSN: Meloni M, Caporali A, Cesselli D, Avolio E, Fortunato O, Rowlinson J, Spinetti G, Ascione R, Beltrami AP, Madeddu P, Emanueli C (2012). Effects of Nerve Growth Factor on Processes Regulating Bone Marrow Progenitor Cells Mobilization after Myocardial Infarction. CIRCULATION, ISSN: Ferro F., Spelat R., D'Aurizio F., Falini G., De Pol I., Pandolfi M., Beltrami A. P., Cesselli D, Beltrami C. A., Curcio F. (2011). Hydroxyapatite (HA) stimulates murine periosteal clonal cells to develop osteoblastic-clastic phenotype favoring its own reabsorption after long-term three-dimensional in vitro culture. BONE, vol. 48, p. S130, ISSN: , doi: /j.bone Corvaglia Stefania, Ianeselli Luca, Cesselli D, Beltrami Antonio P., Scoles Giacinto, Scaini Denis, Casalis Loredana (2011). Shaping substrates at the nanoscale for single cell characterization. EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS, vol. 40, p. 226, ISSN: Cesselli D: Advances and Prospects of Nanotechnology in Stem Cells. Joint ICTP-KFAS Conference on Nanotechnology for Biological and Biomedical Applications (Nano-Bio-Med), (10-14 October 2011), (Miramare, Trieste - Italy). D alessandra Y, Beltrami AP, Carena MC, Devanna P, Fortini C, Cecaro F, Ferrari R, Cesselli D, Toffoletto B, Bergamin N, Pompilio G, Capogrossi MC. Abstract 8443: Circulating MicroRNAs Expression in Human Plasma is Dysregulated by Heart Failure. Circulation. 2011;124(21 Supplement):A8443. Caragnano A, Zanon V, Toffoletto B, Bergamin N, Finato N, Mariuzzi L, Livi U, Sorrentino M, Cesselli D, Beltrami AP, Beltrami CA. Novel therapeutic approaches to treat human cardiac stem cells. 25th International Meeting Adriatic Society of Pathology. Duino-Trieste, June 25/ Pucer A, Bourkoula E, Musiello D, Caliò A, Sorrentino M, Puppato E, Toffoletto B, Ius T, Cesselli D, Beltrami AP, Skrap M, Beltrami CA. Tumor supporting cells from low- and high- grade glioma as a model to identify new prognostic factors. 25th International Meeting Adriatic Society of Pathology. Duino-Trieste, June 25/ Toffoletto B, Puppato E, Bergamin N, Sorrentino M, Cesselli D, Beltrami AP, Beltrami CA. Circulating microparticles. 25th International Meeting Adriatic Society of Pathology. Duino-Trieste, June 25/ Avolio E, Katare R, Picco F, Cesselli D, Beltrami AP, Madeddu P, Beltrami CA. Heart failure and diabetes. 25th International Meeting Adriatic Society of Pathology. Duino-Trieste, June 25/ Bourkoula E, Pucer A, Poz A, Comisso E, Avellini C, Marzinotto S, Mariuzzi L, Baccarani U, Cesselli D, Beltrami AP, Beltrami CA. Isolation, characterization and role of tumor supporting fibroblasts in human liver cancer. 25th International Meeting Adriatic Society of Pathology. Duino-Trieste, June 25/ Bergamin N, Vagnarelli G, Bourkoula E, Rigo S, Cesselli D, Beltrami AP, Dardis A, Bembi B, Beltrami CA. Niemann Pick-C: a novel in vitro approach to a rare disease25th International Meeting Adriatic Society of Pathology. Duino-Trieste, June 25/ Ogorek B, Hosoda T, Rondon C, Gurusamy N, Gatti A, Bardelli S, 66

7 Page 7/12 - Curriculum vitae of Quaini F, Bussani R, Silvestri F, Cesselli D, Beltrami AP, del Monte F, Rota M, Urbanek K, Leri A, Beltrami CA, Anversa P, Kajstura J. Abstract 17367: Myocyte Turnover in the Aging Human Heart. Circulation. 2010;122(21 Supplement):A Meloni M, Cesselli D, Fortunato O, Caporali A, Avolio E, Cangiano E, Cavazza C, Spinetti G, Madeddu P, Beltrami AP, Emanueli C. Abstract 15891: Effects of Cardiac Nerve Growth Factor Overexpression on Bone Marrow and Peripheral Blood Progenitor Cells after Myocardial Infarction. Circulation. 2010;122(21 Supplement):A Cesselli D. A novel method to isolate and expand in vitro stem cell lines from human low- and high-grade gliomas. Glioma invasion forum Pirano. Beltrami AP, Cesselli D et al. Multipotent adult stem cells obtained from failing hearts are funtionally impaired. Acta Phisiologica, Supplemet 665 S1. Cesselli D, Beltrami AP, D'Aurizio F, Marcon P, Puppato E, Bergamin N, Rigo S, Finato N, Marzinotto S, Toffoletto B, Beltrami CA. Abstract 2113: Age and Pathology Impair Cardiac Stem Cells. Circulation. 2009;120(18 Supplement):S595. Poz A, Marzinotto S, Baccarani U, Avellini C, Mariuzzi L, Finato N, Toffoletto B, Puppato E, Rigo S, Beltrami AP, Cesselli D, Beltrami CA. Isolation and characterization of cancer stem cells presents in human liver hepatocellular carcinoma. Adriatic Society of Pathology, 23rd Meeting, June 27 29, 2008, Dubrovnik. Poz A, Marzinotto S, Baccarani U, Avellini C, Toffoletto B, Puppato E, Rigo S, Paolo BA, Cesselli D, Beltrami CA. Isolation and characterization of cancer stem cells presents in human liver hepatocellular carcinoma. Cellular Oncology. 2008;30(2):141. Musiello D, Gallelli A, Puppato E, Toffoletto B, Ius T, Vindigni M, Beltrami AP, Cesselli D, Skrap M, Beltrami CA. A new method to isolate and in viro expand cancer stem cells from human gliomas. Cellular Oncology. 2008;30(2):124. Musiello D, Gallelli A, Marzinotto S, Puppato E, Toffoletto B, Ius T, Vindigni M, Beltrami AP, Cesselli D, Skrap M, Beltrami CA. Isolation, characterization and comparison of cancer stem cells obtained from low-grade astrocytomas and their recurrences. Cellular Oncology. 2008;30(2): Cesselli D, Odreman F, Musiello D, Gallelli A, Beltrami AP, Ius T, Vindigni M, Skrap M, Vindigni A, Beltrami CA. Proteomics of stem cell lines obtained from low- and high-grade human astrocytomas. Cellular Oncology. 2008;30(2): Late-Breaking Basic Science Poster at the American Heart Association Annual meeting (Orlando, Florida). D'Aurizio F, Marcon P, Bergamin N, Martini S, Puppato E, Toffoletto B, Finato N, Livi U, Poz A, Cesselli D, Beltrami AP, Beltrami CA. Dynamic Evaluation Of Cardiac Stem Cell (CSCs) Outgrowth From Human Primary Explants. Late-Breaking Basic Science Poster Abstracts. AHA Scientific Sessions 2007 in Orlando, Florida. Circulation Research 2007, 101: P. Marcon, F. D aurizio, N. Finato, L. Mariuzzi, M. Pandolfi, M. Bottecchia, U. Livi, A.P. Beltrami, D. Cesselli, C.A. Beltrami. Pluripotent stem cells obtained from failing heart are functionally impaired. Eur Heart J. 2007;Vol.28(Abstract Supplement):786. Puppato E, Bergamin N, Cesselli D, Beltrami AP, Toffoletto B, Di Chiara A, Dall armellina E, Fioretti PM, Beltrami CA. In humans, Mesenchymal Stem Cells (MSCs) are mobilized into the peripheral blood immediately after an Acute Myocardial Infarction. Eur Heart 77

8 Page 8/12 - Curriculum vitae of J. 2007;Vol.28(Abstract Supplement):515. Saretta F., Ganis R., Canciani M., Toffoletto B., Cesselli D (2007). Feasibility of flow cytometry in diagnosis of drug allergy in children. ALLERGY, vol. 62, p. 530, ISSN: Baccarani Umberto, Beltrami Antonio Paolo, Cesselli D, Bergamin Natasha, Marcon Patrizia, Rigo Silvia, Poz Alessandra, Beltrami Alberto, Bresadola Fabrizio (2007). Adult human heart, liver and bone marrow harbor a similar population of pluripotent mesenchymal stem cells. TRANSPLANT INTERNATIONAL, vol. 20, p , ISSN: Musiello D, Gallelli A, Puppato E, Toffoletto B, Ius T, Vindigni M, Mariuzzi L, Finato N, Beltrami AP, Cesselli D, Skrap M, Beltrami CA. A new method to isolate and in vitro expand cancer stem cells from human gliomas. Adriatic Society of Pathology, 23rd Meeting, June 27 29, 2008, Dubrovnik. Gallelli A, Odreman F, Musiello D, Beltrami AP, Cesselli D, Ius T, Vindigni M, Nicoletta F, Mariuzzi L, Skrap M, Vindigni A, Beltrami CA. Proteomics of stem cell lines obtained from low- and highgrade human astrocytomas. Adriatic Society of Pathology, 23rd Meeting, June 27 29, 2008, Dubrovnik. Urbanek K, Cesselli D, Rota M, Nascimbene A, De Angelis A, Amano K, Miqueo AG, Rotatori F, Loredo M, Vitale S, Hosoda T, Bearzi C, Boni A, Bolli R, Kajstura J, Anversa P, Leri A. Abstract 1265: Cardiac Stem Cell Niches Control Cardiomyogenesis in the Adult Mouse Heart. Circulation. 2006;114(18 Supplement):II_238. Puppato E, Rigo S, Bergamin N, Beltrami AP, Cesselli D, Dall'Armellina E, Di Chiara A, Masolini P, D'Aurizio F, Marcon P, Poz A, Fioretti PM, Beltrami CA. Abstract 796: In Humans, Mesenchymal Stem Cells (MSCs) are Mobilized into the Peripheral Blood Immediately after an Acute Myocardial Infarction (AMI). Circulation. 2006;114(18 Supplement):II_139. Marcon P, Bergamin N, Beltrami AP, Cesselli D, Puppato E, D'Aurizio F, Rigo S, Mariuzzi L, Finato N, Pandolfi M, Bottecchia M, Poz A, Marzinotto S, Livi U, Beltrami CA. Abstract 2046: Human Cardiac Stem Cells are Involved in Pathological Processes. Circulation. 2006;114(18 Supplement):II_412-II_413. Late-Breaking Basic Science Abstract at the American Heart Association Annual meeting (Chicago, Illinois). Rigo S, Beltrami A, Cesselli D, Bergamin N, Marcon P, Puppato E, D'Aurizio F, Coletto A, Damiani D, Fanin R, Beltrami CA. Mobilized peripheral blood contains a very rare population of pluripotent mesenchimal stem cells able to differentiate into myocytes. Circulation Research. 2006;99(11): Science Hotline Session of the European Society of Cardiology / World Heart Federation Joint Meeting. Barcelona, Spain. Beltrami AP, Marcon P, Cesselli D, Bergamin N, D Aurizio F, Beltrami CA. Human cardiac stem cells are involved in pathological processes. World Congress of cardiology, Barcellona Science Hot-line. Abstract Castaldo C, Nurzynska D, Di Meglio F, Vitale S, Cesselli D, Beltrami AP, Muller P, Montagnani S. Epicardium contains a population of c- kit positive cells that may contribute to myocardial regeneration. European Heart Journal 2005; 26 (Abstract Supplement):213. Cesselli D, Marcon P, Puppato E, Rigo S, Burelli S, Bergamin N, Beltrami AP, Beltrami CA. Human atria are a feasible source of multipotent adult progenitor cells. European Heart Journal 2005; 26 (Abstract Supplement):222. D'Aurizio F, Machin P, Mariuzzi L, Finato N, Cesselli D, Beltrami AP, 88

9 Livi U, Beltrami CA. Evaluation of human cardiac growth reserve by means of cell ploidy and CDK inhibitors. European Heart Journal 2005; 26 (Abstract Supplement):318. Cesselli D, Beltrami AP, Marcon P, Burelli S, Bergamin N, Rigo S, D'Aurizio F, Finato N, Mariuzzi L, Baccarani U, Puppato E, Pandolfi M, Bottecchia M, Damiani D et al. (2005). Human atria are a feasible source of multipotent mesenchymal stem cells. CIRCULATION, vol. 112, p. U106, ISSN: Beltrami A, Cesselli D, Rigo S, Marcon P, Bergamin N, Burelli S, Puppato E, Bottecchia M, D'Aurizio F, Beltrami CA, Fanin R, Damiani D (2005). Multipotent Mesenchymal Stem Cells Can Be Isolated and Grown from Many Tissues (Bone Marrow, Liver and Heart). CYTOTHERAPY, vol. 7(Suppl.1), ISSN: Beltrami AP, Cesselli D, Damiani D, Baccarani U, D'Aurizio F,Masolini P, Livi U, Beltrami CA: Isolation, characterization and in vitro growth of human multipotent adult cardiac progenitor cells. Eur Heart J 25(Abstract Supplement): 255, Beltrami AP, Cesselli D, Damiani D, D'Aurizio F, Mariuzzi L, Finato N, Baccarani U, Bottecchia M, Fanin R, Beltrami CA. (2004). In the adult human heart resides a population of non-blood-borne multipotent cardiac progenitor cells. CIRCULATION, vol. 110, p. 239, ISSN: Cesselli D, Pulpito L, Castriotta L, Finato N, Livi U, Mariuzzi L, Bussani R, Silvestri F, Beltrami CA, Beltrami AP: Cardiac cell polyploidy: evaluation and significance. Proceedings of the International conference on Applied Genomics 9th ESACP/16th ISDQP meeting, Amsterdam 1-4 October 2003, p51. Muller P, Barlucchi L, Bohm M, Beltrami AP, Cesselli D, Hintze TH, Nadal-Ginard B, Leri A, Kajstura J, Anversa P: Identification of Cardiac Stem Cells in the Dog Heart. Circulation 108 (supplement IV): IV-156, Leri A, Bearzi C, Cascapera S, Torella D, Cesselli D, Rastaldo R, Quaini F, Urbanek K, Anversa P: Symmetric and Asymmetric Division of Cardiac Stem Cells in the Mouse Heart. Circulation 108 (supplement IV): IV-33, Muller P, Barlucchi L, Bohm M, Beltrami AP, Cesselli D, Hintze TH, Nadal-Ginard B, Leri A, Kajstura J, Anversa P (2003). Identification of cardiac stem cells in the dog heart. CIRCULATION, vol. 108, p , ISSN: Torella D, Cesselli D, Kajstura J, Anversa P, Leri A (2003). Molecular control of cardiac primitive cell migration in the infarcted heart. JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY, vol. 35, p. A43, ISSN: Cesselli D, Kajstura J, Jakoniuk I, Urbanek K, Kasahara H, Nadal- Ginard B, Quaini F, Anversa P, Leri A (2002). Cardiac stem cells (CSC) are endowed in niches of the adult mouse heart and possess the ability to divide and differentiate in the various cardiac lineages. CIRCULATION, vol. 106, p. 286, ISSN: Chimenti S, Barlucchi L, Limana F, Jakonluk I, Cesselli D, Beltrami AP, Mancarella S, Castaldo C, Nadal-Ginard B, Leri A, Kajstura J, Anversa P (2002). Local mobilization of resident cardiac primitive cells by growth factors repairs the infarcted heart. CIRCULATION, vol. 106, p. 14, ISSN: Fiordallso F, Leri A, Cesselli D, Safai B, Nadal-Ginard B, Anversa P, Leri A (2000). Hyperglycemia activates p53 and p53-dependent genes leading to myocyte cell death. CIRCULATION, vol. 102, p. 241, ISSN: Page 9/12 - Curriculum vitae of 99

10 Shortcomings, our Solutions, Our Future Challenges Biomedical Applications (Nano-Bio-Med), October 2011 Miramare, Trieste Italy. Titolo della presentazione: ADVANCES AN in Pathology. Dipartimento di Scienze Matematiche e Informatiche con patrocinio della Facoltà di Medicina dell Università degli Studi di Udine Bologna. Sezione: Cellule staminali in patologia tumorale. Titolo del presentazione: INTERAZIONE CELLULE STAMINALI E STROMA Trieste. 6 novembre Titolo della presentazione: ROLE OF STE Ospedaliero Universitaria di Udine. Sezione: Medicina Rigenerativ Titolo della presentazione: CELLULE STAMINALI E CANCRO. Accreditat method to isolate and expand in vitro stem cell lines from human low Staminale all'ingegneria Tissutale: una promessa ed una sfida anche pe i trapianti. Piazza del Castello Udine Titolo del Reserach). Bologna, Italy June Titolo della presentazione ADULT HUMAN ORGANS (HEART, LIVER AND BONE MARROW) HARBOR Università degli Studi di Udine-Cattedra 10di Anatomia Patologica. 2 settembre Titolo della presentazione: CELLULE STAMINALI: L FONTI, RILEVANZA CLINICA E TERAPEUTICA, NUOVE FRONTIERE NELL Universitaria di Udine. Titolo della presentazione: POST ISCHEMI 2006, Centro Congressi AREA Science Park Trieste, Sezion PATHOPHISIOLOGY OF HEART FAILURE. Titolo della presentazion MOLECULAR MECHANISMS OF MYOCARDIAL REMODELING AND FAILUR Università degli Studi di Udine-Cattedra di Anatomia Patologica. 1 giugno Titolo della presentazione: NUOVE MICROSCOPIE CONFOCALE, IN VIVO CELL IMAGING, FISH E FLOW-FISH: APPLICAZION ALLA DIAGNOSI ISTOPATOLOGICA E NUOVI ASPETTI PER LA RICERCA presentazione: POLIPLOIDIA CARDIACA: VALUTAZIONE E SIGNIFICATO. Invited Speaker Seminario Circulating Tumor Cells: Current Detection Systems, the Centro di Riferimento Oncologico di Aviano (PN). ECM Accreditation. Joint ICTP-KFAS Conference on Nanotechnology for Biological an PROSPECTS OF NANOTECHNOLOGY IN STEM CELL. 3rd Notthingam Image Analysis Training School, Practical Image Analys Giugno Titolo della presentazione: SIAPEC 5 congresso triennale, La forza delle radici, 24 settembre 201 Accreditato ECM. The Yellow Seminars. Fondazione Italiana Fegato. Area Science Par CELLS IN CANCER. Incontri scientifici della società medica del Friuli , Aziend ECM Glioma invasion forum Pirano. Titolo della presentazione: A nov and high-grade gliomas. Associazione Donatori d Organo (ADO). Tavola Rotonda "Dalla Cellu presentazione: CELLULE STAMINALI MULTIPOTENTI. XIX WORLD CONGRESS OF THE ISHR (International Society of Hea SIMILAR POPULATION OF MULTIPOTENT ADULT STEM CELLS Vecchi problemi e nuove metodiche in Anatomia Patologica e Oncologi RICERCA. Accreditato ECM Pre-hospital emergency care Azienda Ospedalier CARDIAC REMODELLING. Accreditato ECM 8th International Congress of the Cell Trasplantation Society, Milan, maggio 2006: Title of the presentation: Cardiac Stem Cell Niches. Summer School - Advanced Topics in Molecular Medicine, JUL Accreditato ECM Vecchi problemi e nuove metodiche in Anatomia Patologica e Oncologi Accreditato ECM Congresso Nazionale SIAPEC-IAP, Chieti 22-24/09/2005. Titolo del Page 10/12 - Curriculum vitae of 1010

11 XXI LATIN MEETING ON VASCULAR RESEARCH, Abbazia di Rosazz (Udine-Italy) settembre Titolo della presentazione: CARDIA STEM CELLS. Vecchi problemi e nuove metodiche in Anatomia Patologica e Oncologi Università degli Studi di Udine-Cattedra di Anatomia Patologica. 2 maggio Titolo della presentazione: CELLULE STAMINALI CANCRO O CANCRO DELLE CELLULE STAMINALI. Accreditato ECM Stem cell day. Azienda ospedaliera di rilievo nazionale Antonio Cardare di Napoli Titolo della presentazione: CARDIAC STE CELLS. Accreditato ECM Previously Supported Researches: D. Cesselli participated in projecting and writing the following grants; Progetto di ricerca del Ministero della Salute: Giovani Ricercatori. Impiego di cellule staminali multipotenti dell adulto da tessuto adiposo per la rigenerazione cardiovascolare. GR Finanziamento totale: euro. 4 Unità Operative. Accettata proroga di un anno. European Grant, 7FP, Ideas, ERC Advanced Grant Molecular Nanotechnology For Life Science Application: QUantitative Interactomics for Diagnostics, Proteomics and QUantitative Oncology,(Quidroquo) proposal n AIRC 5 per mille. Title: Application of Advanced Nanotechnology in the Development of Innovative Cancer Diagnostics Tools. Rif PI G. Toffoli. 14 Unità Operative. Attività all'interno delle unità di ricerca dirette dal Prof. Beltrami e dal Prof. Scoles (Università degli Studi di Udine). Programma per la Cooperazione Transfrontaliera Italia-Slovenia Title: Identificazione di nuovi marcatori di cellule staminali tumorali a scopo diagnostico e terapeutico Coordinator: Tamara Lah (NIB Lubiana). Project Partner CA Beltrami (Azienda Ospedaliero Universitaria di Udine). Progetto FIRB Accordi di programma Title: FIERCE FInd new molecular and CEllular targets against cancer. Pr. RBAP11Z4Z Coordinator: M. Giacca (ICGEB). PP CA Beltrami (Università di Udine). 8 Unità Operative. Finanziamento Unità Operativa: 769,999 euro. Progetto: FIRB accordi di programma 2011 pr. RBAP11ETKA_007 Nanotechnological approaches for tumor theragnostic. Coordinator: Maurizio Prato. PP AP Beltrami (Università di Udine). Ministero della Salute_Progetto Integrato di Oncologia Title: Sviluppo e implementazione di reti di piattaforme tecnologiche avanzate per la caratterizzazione molecolare dei tumori, atte a predire e valutare la risposta terapeutica dei pazienti. Coordinator FVG: CA Beltrami Associazione Italiana per la Ricerca sul Cancro (AIRC): Regional Grant 2005 pr.1023 (P.I. Antonio Amoroso); Title: New approaches for studying genetics, early molecular diagnosis and prognostic factors relevant for HCC. Friuli Venezia Giulia Regional Grant: Art.11 L.R. 11/2003 (P.I. Carlo Alberto Beltrami); Title: Stem cell characterization and utilization, through tissue engineering technologies, in human therapy. MIUR Progetto: PRIN 2006 pr (P.I. Carlo Alberto Beltrami); Title: Cellule staminali mesenchimali (MSC) e cellule staminali mesenchimali pluripotenti dell'adulto (PMSC): biologia, immunomodulazione dei trapianti e ingegneria tissutale. 5 Unità Operative. Finanziamento totale: ,00. Regione Friuli Venezia Giulia,-Legge Regionale Trapianti Titolo: Isoalmento e banking di cellule adulte di fegato e cuore e dei loro precursori staminali mesenchimali per la terapia e trapianto cellulare. Page 11/12 - Curriculum vitae of 1111

12 Regione Friuli Venezia Giulia. finanziato ai sensi dell articolo 23 della LR 26/2005. Title: Utilizzo terapeutico di cellule staminali umane multipotenti. Coordinatore: CA Beltrami (University of Udine) MURST Progetto: PRIN 2004 pr (P.I. Carlo Alberto Beltrami); Title: Study on the role played by cells and microenvironment in regenerative medicine and cell therapy. Progetto di ricerca finalizzata Ministero della Salute P.R.F. 10/04 (P.I. Carlo Alberto Beltrami); Titolo: Identification, characterization, in vitro growth and therapeutical utilization of human multipotent mesenchymal cells. Page 12/12 - Curriculum vitae of 1212

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