Joshua Blose, Ph.D., Biochemistry

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1 Current Research Joshua Blose, Ph.D., Biochemistry Our research group is interested in learning more about how the cellular environment influences the stability and structure of nucleic acids such as DNA and RNA. The focus of one project in the lab is determining how cellular conditions influence nucleic acids to undergo conformational changes from typical A and Bforms to their Zform. A second project is focused on determining how cellular conditions influence the stability of highly conserved hairpin structures. Topics of Interest and Expertise Nucleic acid chemistry (DNA/RNA) Biomolecular folding and structure formation Biological spectroscopy and structural characterization techniques Binding assays, enzyme kinetics, biological thermodynamics

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3 Michael Brown, Ph.D., Analytical Chemistry Current Research Our research group is interested in the determination of postmortem interval (PMI) by analysis of citrate content of bone. We are collaborating with Dr. Ann Bunch (Brockport Criminal Justice Department) and researchers at the Univ. of Tennessee and Onondaga County Medical Examiners office. The project is funded by a grant from the National Institute of Justice. Topics of Interest and Expertise Analytical Chemistry: GC, HPLC, GCMS, UVVis spec., small molecule membrane diffusion, modelling of membrane diffusion process Environmental Chemistry: water and atmospheric chemistry; drinking water disinfection byproducts, remediation consultation Analytical Forensic Chemistry: dating of skeletal remains; bone chemistry

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5 My background: Elizabeth Gregory, MS Laboratory Manager BA, The College at Brockport Chemistry & Mathematics, Physics Minor Undergraduate research, organic synthesis MS, University of Rochester PI: Patrick Holland, inorganic synthesis What I do As lab manager, I am responsible for: Preparing CHM 121, 205, 206, 260, 05 and 06 labs Hiring, scheduling and training all lab assistants Purchasing/receiving Accounting Teaching CHM 01 and coordinating/teaching CHM 260 laboratory

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7 Mark P. Heitz, Ph.D., Physical / Analytical Chemistry Current Research Research in the Heitz lab is generally focused on molecular solvation dynamics in solution. Current chemical systems of interest include surfactants, ionic liquids, supercritical fluids, and proteins. We study these systems using a broad array of experimental and computational techniques. Topics of Interest and Expertise Solvation dynamics, solution thermodynamics, physical properties characterization, micro and nanoheterogeneous media. Instrumental analysis techniques include: steadystate and timeresolved optical absorption and emission spectroscopies, density, viscosity, and conductivity.

8 Chemical Dynamics in Solution GENERAL SYSTEMS (micro and nanoheterogeneity) Ionic Liquids Surfactants (reverse micelles) Dense Gas/Supercritical Fluids Proteins

9 Solvation Dynamics Slow Solvent Fast Solvent dielectric friction strength of polar interactions solvent response time

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11 Techniques Rheology/Physical Properties Density Viscosity Conductivity Solution Thermodynamics Solvation Dynamics (Laser Spectroscopy) Time Resolved Fluorescence Computational Chemistry

12 Ongoing work O C O C C H 2 H 2 C S C H 2 C NH Me 2 N Acrylodan (Cysteine4)

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14 Dr. Kelley s Research Interest and Expertise 50 nm D AFM image of Fe 2 Ni nanoparticles on mica substrate 200 nm AFM images show patterns, shapes, and letters written with molecules on Au surfaces at the nanoscale (nanografting)

15 My area of expertise is in material science. I am also trained as an analytical chemist. Using various microscopy methods (i.e. AFM, SEM, and TEM) To gain insight into how nanomaterials and their arrangement/orientation on surfaces influence their chemical properties. Synthesizing nanomaterials with green chemistry methods Designing heterometallic nanoparticles Typically less than 10 nm Functionalized metallic core shell Found in nature or can be synthesized 15

16 Topics related to my research interest Microscopy Materials (Nano or Microfabrication) Polymers Microwave Chemistry Surface Science (Crystal lattices of surfaces) Common analytical techniques Chemical Education (Caution: You must choose a topic rich in Chemistry)

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18 Current Research Maggie Logan, Organic Chemistry My research students are currently working on two projects. One is the development of efficient palladiumcatalyzed hydrodechlorination of aryl chlorides (which are related to PCB s), particularly in green solvents, phosphonium ionic liquids. The other is the synthesis and antioxidant properties of diaryl tellurides, including watersoluble ones, and understanding how these antioxidant properties relate to the chemical structure of the molecules. H CO Cl Pd cat HCO 2 Na R 4 PX H CO Topics of Interest and Expertise H Organic chemistry, including synthetic, organometallic, and physical organic chemistry Medicinal chemistry (in which I worked for several years at Eastman Kodak) Clinical chemistry (in which I worked for several years at EK and Johnson & Johnson) Structureproperty relationships of coumpounds N Te 2

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20 Carly Reed, Ph.D., Inorganic Chemistry Current Research Research in the Reed lab this year has focused on developing more efficient syntheses for dimetal paddlewheel complexes using microwave irradiation. Currently we are exploring how this synthetic technique can be applied to create metalorganic frameworks and how the synthesis affects the crystallinity and catalytic ability of products. O O O Re Cl O O Re O O Cl O Topics of Interest and Expertise Inorganic elements and chemistry, inorganic synthesis, airfree synthesis techniques, metalorganic frameworks, solidstate chemistry, nanomaterials, metals, gas separation and storage, catalysis, molecular orbital energy diagrams, molecular wires, molecular magnets, photocatalysis, light absorption and emission by molecules, photovoltaics, LEDs.

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22 Jessica Smith, Ph.D., Bioorganic Chemistry Research Interests My interests span the fields of organic chemistry and biology with focus on using bacterial cells to generate cyclic peptides as potential drugs. One such class of peptides utilizes aminothiol functionalized organic linkers to create headtotail constrained cyclic peptides. These peptides were successful in disrupting the proteinprotein interaction between a tumor suppressor protein, p5, and an oncogenic protein, HDM2. P5interaction domain HDM2 Designed Cyclic Peptide Topics of Interest and Expertise Peptide generated in vivo Peptide chemistry, bioorthogonal chemistry, synthetic chemistry Proteinprotein interactions, oncogenic proteins Synthetic biology (bioengineering), molecular biology Mass spectrometry of peptides, protein purification, biophysical characterization

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24 Brandy Sreenilayam, Ph.D., Biochemistry Current Research Our research group is interested in learning more about the protein LGN. One project is focused on purifying LGN to 95% so protein crystals can be grown and the D structure can be determined using Xray crystallography. A second project is in collaboration with Dr. Laurie Cook (Brockport Biology Department) and is looking at localization of LGN during cell division if residue T450 is phosphorylated or not. Topics of Interest and Expertise Metabolism/metabolic pathways & diseases that disrupt normal metabolism in mammals (i.e. diabetes) Proteinprotein interactions (binding, kinetics, localization) Gproteins, GPCRs Protein structure by Xray crystallography