8 th Senftenberg Innovation Forum on Multiparametric Analysis. May Senftenberg Germany

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1 8 th Senftenberg Innovation Forum on Multiparametric Analysis AUTOIMMUNE Diagnostics May Senftenberg Germany

2 In cooperation with: Media Partner: Recent developments of multiparametric technologies in applied genomics and proteomics research enriched enormously the discovery of novel biomarkers and improved applications in the clinical practice. Comprehensive technologies also simplify clinical diagnosis of autoimmune diseases and lower costs while performing large panels of assays in single wells with high sensitivity and specificity. Methodologies include autoantibody detection and cell pattern recognition but also PCR-based approaches. Supported by: The 8th Senftenberg Innovation Forum on Multiparametric Analysis will focus on advances in multiparametric autoimmune diagnostics in research and the healthcare market. Multiparametric technologies are a prerequisite for precision medicine that places the patient at the center of integrated clinical research, diagnosis and therapy. Various analytical platforms and novel biomarkers will be presented at this forum as well as new systems that combine cell-based tests with a secondary technology such as protein microarrays, integrated chip technologies or microbeads. Accompanying Exhibitions: Posters, scientific demonstrators as well as industrial products and services will be presented. Participation is free of charge. Prior registration is requested. Further details are available at:

3 Schedule - May 7 th 9.15 Welcome Birger Hendriks, BTU Cottbus - Senftenberg, Germany 9.45 Opening Lecture: Historical perspective on autoantibodies René L. Humbel, Laboratoire Luxembourgeois d Immunopathologie (LLIP), Luxemburg City, Luxemburg Yes, we combine CytoBead Assays CytoBead ANCA CytoBead ANA CytoBead CeliAK Automatic fast diagnostics Test principle: combination of screening and differentiation in one well Coffee Session I: Autoimmune Diseases Key Note: Cutting edge autoantibody diagnostics: Learning from Liverpool Dimitrios P. Bogdanos, King s College London School of Medicine, London, United Kingdom New aspects of antibody diagnostics in coeliac disease Thomas Mothes, Universitätsklinikum Leipzig, Leipzig, Germany Multiparameter diagnostic: Benefits and limitations Heinz-Detlef Gremmels, MDI Laboratorien GmbH MVZ, Berlin, Germany Lunch, Poster Session and Industrial Exhibition Example: CytoBead ANCA GBM Granulocytes PR3 MPO Reference bead Reference bead PR3 bead negative PR3 bead positive MPO bead positive Ethanol fixed granulocytes (panca) MPO bead negative Ethanol fixed granulocytes (canca)

4 Schedule - May 7 th Session II: New Biomarkers for Key Note: Antinuclear antibodies by indirect immunofluorescence and by solid phase assay Xavier Bossuyt, Katholieke Universiteit Leuven, Leuven, Belgium Improvement of autoimmune diagnostics by implementation of novel autoantibodies Karsten Conrad, Technical University Dresden, Dresden, Germany NETS and inflammation in ANCA-associated vasculitis Elena Csernok, Klinikum Bad Bramstedt GmbH, Bad Bramstedt, Germany Aptamers, a new tool for diagnostics and therapy Ingolf Schimke, Charité Universitätsmedizin Berlin, Berlin, Germany (tbc) Coffee Anti-hnRNP B1 autoantibodies in rheumatoid arthritis and systemic sclerosis Sergey Lapin, St. Petersburg Pavlov State Medical University, St. Petersburg, Russian Federation Development of tools for a multi-substrate microbead-chip for screening of serological markers and epitopes Stefan Rödiger, BTU Cottbus-Senftenberg, Senftenberg, Germany Identification and characterization of novel autoantibodies in Myasthenia gravis Stephan Kröger, Ludwig-Maximilians-University Munich, Germany Get Together

5 Schedule - May 8 th Session III: New Technologies for Clinical Diagnostics 9.15 Key Note: Improving early cancer diagnostics using protein and peptide arrays Andreas Weinhäusel, AIT Austrian Institute of Technology, Vienna, Austria Please visit our Industrial Exhibition! 9.40 Novel diagnostic systems based on single molecule detection Till Korten, Max Planck Institute of Molecular Cell Biology and Genetics, Dresden, Germany Novel approaches in generating monoclonal antibodies for diagnostic use Katja Hanack, University of Potsdam, Potsdam, Germany Fully automated analysis of γ-h2ax foci to monitor DNA damage Annika Willitzki, Otto-von-Guericke University, Magdeburg, Germany Coffee Session IV: Research and Development in SME s Videoscan a new device for evaluation of antibody bead assays in autoimmune and infectious diseases Werner Lehmann, Attomol GmbH, Lipten, Germany Novel CytoBead TM technology for comprehensive autoantibody assessment Kai Großmann, Medipan GmbH, Dahlewitz, Germany Directed immobilization of peptides for different applications N. N., PolyAn GmbH, Berlin, Germany Closing Remarks

6 Scientific Exhibition Notes AKLIDES Platform Technology The AKLIDES system is a platform technology for the multiplex diagnostics using digital multi-color immunofluorescence. It represents the worlds s first system for the automatic and objective analysis of immunofluorescence testing in routine diagnostics. There also exists an application for the automatic determination of DNA double-strand breaks via γh2ax foci. Fraunhofer ivd-platform The ivd-platform is a system, which enables measurements of diagnostic parameters directly at the patient s bedside. The system contains a credit card-sized cartridge and a base-unit. For usage, a drop of blood has to be applied to the cartridge, which will then be inserted into the base unit. After 15 minutes the results are displayed, enabling a fast therapeutic decision. VideoScan Technology VideoScan 1.1 is a highly versatile fluorescence microscopic platform and encompasses a tool kit for the multiplex detection of serological markers. Tools include aptamer, antibody and epitope mapping technologies. Currently, up to 20 targets per cavity can be used to monitor changes in real-time. VideoScan 1.1 is a useful tool for highthroughput screening.

7 Contact: Berlin Partner für Wirtschaft und Technologie GmbH Zentrum für Molekulare Diagnostik und Bioanalytik (ZMDB) Dr. Günter Peine Director Management and Coordination Tel BTU Cottbus-Senftenberg Dr. Claudia Liebsch / Dr. Stefan Rödiger Tel claudia.liebsch@hs-lausitz.de Venue: BTU Cottbus-Senftenberg Campus Senftenberg Konrad-Zuse-Bau Großenhainer Straße Senftenberg Germany Further Information: Investing in your future! EUROPEAN UNION European Regional Development Fund The Center for Molecular Diagnostics and Bioanalysis (ZMDB) is a Flagship Project of the Joint Innovation Strategy Berlin-Brandenburg at Berlin Partner für Wirtschaft und Technologie GmbH. The ZMDB is funded by the states of Berlin and Brandenburg and co-financed by the European Regional Development Fund (ERDF) of the European Union. Investing in your future!