Hammar Reliance Documents Updated 1/1/2014. Table of Contents

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1 Hammar Reliance Documents Updated 1/1/2014 Note: this list reflects Dr. Hammar s most commonly cited reliance documents. Table of Contents Core Reliance Documents... 4 Books... 4 Attribution... 4 Background Level... 5 Concentrations... 5 Environmental Exposure and EPA... 5 Familial/Paraoccupational/Non-occupational Exposures... 6 Fiber Burden... 6 Genetic Alterations... 7 Genetic Susceptibility... 7 Governmental and Other Agencies Concerning No Safe Level... 7 Historical... 8 IMIG Consensus Statement... 8 Low Level Exposure... 9 PEL... 9 Translocation... 9 Tumorigenesis Alpha by Author Cullen Dodson Egilman Hammar (also see CV) Heller Henderson Henley Hillerdal Hodgson and Darnton Iwatsubo Langer and Nolan Page 1 of 51

2 Leigh Lemen Nicholson Ordónez Reid and de Klerk Rodelsperger Rolland Saracci Selikoff Suzuki Welch Lung cancer, Asbestosis, and Pleural Plaques Lung Cancer Risk According to Occupation Synergism (interactions/mechanisms of the combined effect of asbestos and smoking in the etiology of lung cancer) Lung Cancer, Cigarette Smoking, and HPV Calidria/UICC-B Asbestos Chrysotile Asbestos Talc Mesothelioma by Type Deciduoid Mesothelioma Localized Malignant Mesothelioma Pericardial Mesothelioma Peritoneal Mesothelioma Peritoneal mesothelioma case reports Pseudomesotheliomatous Adenocarcinoma Small cell mesothelioma Tunica Vaginalis Testis Meso Well-differentiated Papillary Mesothelioma Selected Cancers Colorectal, Esophageal, Laryngeal, Pharyngeal, Stomach, Kidney/Renal, Ovarian, Lymphoma, Autoimmune, Pseudomeso Kidney/Renal Carcinoma Multiple Myeloma Page 2 of 51

3 Non-malignant Asbestos-related Diseases Occupations/Trades Associated with Asbestos Exposure List of Occupations Associated with Asbestos Exposure General Construction: Carpenters/Electricians Insulation Workers Longshoremen/Dock Workers/Shipbuilding Industry/Shipyard Workers Maintenance Workers Merchant Marines/Seamen Plumbers/Pipefitters Pulp and Paper Mill Workers School Teachers Textile Workers Products Associated with Asbestos Exposure Cement Pipe Drywall, Taping, and Joint Compounds Floor Tiles Friction Products Gaskets Kent Cigarettes RT Vanderbilt Talc Regions Registers Miscellaneous Animal Studies Black Spots on the Pleura Metastases SV40 Virus Page 3 of 51

4 Core Reliance Documents Books Dodson RF, Hammar SP, eds. Asbestos: Risk Assessment, Epidemiology, and Health Effects, 2nd ed. Boca Raton: CRC Press/Taylor & Francis Group, Note: 1st edition published in Tomashefski JF Jr., ed. Dail and Hammar s Pulmonary Pathology, 3rd Ed. New York: Springer, Robbins and Cotran Pathologic Basis of Disease, 8th ed. Kumar V, Abbas AB, Fausto N, Aster JC (eds). Philadelphia, PA: Saunders/Elsevier, DeVita, Hellman, and Rosenberg s Cancer: Principles and Practice of Oncology, 8th ed. DeVita VT, Lawrence TS, Rosenberg SA (eds). Philadelphia, PA: Lippincott Williams & Wilkins, Weinberg RA, ed. The Biology of Cancer. New York: Garland Science, Taylor & Francis Group LLC, Galateau-Sallé F, ed. International Mesothelioma Panel: Brambilla E, Cagle PT, Churg AM, et al. Pathology of Malignant Mesothelioma. London: Springer, Institute of Medicine of the National Academies. Asbestos: Selected Cancers. Committee on Asbestos: Selected Health Effects Board on Population Health and Public Health Practices. Washington DC: The National Academies Press, Light RW, Lee YC Gary, eds. Textbook of Pleural Diseases. New York: Oxford University Press, Corrin B, ed. Pathology of Lung Tumors. Churchill Livingstone, 1997: Peters GA, Peters BJ, eds. Asbestos Health Effects, Treatment and Control. The Michie Company, Henderson DW, Shilkin KB, Langlois SL, Whitaker D, eds. Malignant Mesothelioma. New York: Hemisphere, Landrigan PJ, Kazemi H, eds. The Third Wave of Asbestos Disease: Exposure to Asbestos in Place, Public Health Control. Ann N Y Acad Sci, Volume 643. Attribution Helsinki Consensus Report. Asbestos, asbestosis and cancer: The Helsinki criteria for diagnosis and attribution. Scand J Work Environ Health 1997;23: Henderson DW, Rödelsperger K, Woitowitz H-W, Leigh J. After Helsinki: a multidisciplinary review of the relationship between asbestos exposure and lung cancer, with emphasis on studies published during Pathology 2004;36: American Thoracic Society. Diagnosis and initial management of nonmalignant diseases related to asbestos. Am J Respir Crit Care Med 2004;170: Page 4 of 51

5 Background Level Roggli VL, Oury TD, Sporn TA, eds. Pathology of Asbestos-Associated Diseases, 2 nd Ed. New York: Springer, 2004 (Table 2.2). Concentrations Dodson RF, O Sullivan M, Corn CJ, McLarty JW, Hammar SP. Analysis of asbestos fiber burden in lung tissue from mesothelioma patients. Ultrastruct Pathol 1997;21: Environmental Exposure and EPA Magnani C, et al. Pleural malignant mesothelioma and non-occupational exposure to asbestos in Casale Monferrato, Italy. Occup Environ Med 1995;52: Berry M. Mesothelioma incidence and community asbestos exposure. Environ Research 1997;75: Statement by the EPA concerning each and every exposure. U.S. EPA Office of Enforcement and Compliance Assurance: A guideline for ship scrappers: Tips for regulatory compliance, Summer EPA 315. Bourdes V, et al. Environmental exposure to asbestos and risk of pleural mesothelioma: review and meta-analysis. European J Epidem 2000;16: Magnani C, et al. Multicentric study on malignant pleural mesothelioma and non- occupational exposure to asbestos. British Journal of Cancer 2000;83: Orenstein MR, Schenker MB. Environmental asbestos exposure and mesothelioma. Curr Opin Pul Med 2000;6: Pan XL, Day HW, Wang W, et al. Residential proximity to naturally occurring asbestos and mesothelioma risk in California. Am J Respir Crit Care Med 2005;172: EPA Region 9: Response to the November 2005 National Stone, Sand & Gravel Association Report prepared by the R.J.Lee Group, Inc. Evaluation of EPA s analytical data from the El Dorado Hills Asbestos Evaluation Project. April 20, 2006 (Rejection of Berman-Crump and statement that a concentration of f/cc translates in the protocol to an increased cancer risk of 1 in 1,000 exposed individuals, which is outside the acceptable cancer risk ranges of EPA, Cal/EPA and most other state and federal health agencies - see pages of document) Maule MM, et al. Modeling mesothelioma risk associated with environmental asbestos exposure. Environ Health Perspect 2007;115: Kurumatani N, Kumagai S. Mapping the risk of mesothelioma due to neighborhood asbestos exposure. Am J Respir Crit Care Med 2008;178: Rake C, Gilham C, Hatch J, Darnton A, Hodgson J, Peto J. Occupational, domestic and environmental mesothelioma risks in the British population: a case-control study. Br J Cancer 2009;100: Madkour MT, El Bokhary MS, Awad Allah HI, et al. Environmental exposure to asbestos and the exposure-response relationship with mesothelioma. Eastern Mediterranean Health Journal 2009;15: Page 5 of 51

6 Goldberg S, Rey G, Luce D, et al. Possible effect of environmental exposure to asbestos on geographical variation in mesothelioma rates. Occup Environ Med 2010;67: Familial/Paraoccupational/Non-occupational Exposures Vianna NJ, Polan AK. Non-occupational exposure to asbestos and malignant mesothelioma in females. Lancet 1978;1: NIOSH. Report to Congress on Workers Home Contamination Study Conducted Under the Workers Family Protection Act (29 U.S.C. 671a). U.S. Dept of Human and Health Services, Sept DHHS(NIOSH) Publication No Hammar SP et al. Malignant mesothelioma in women. Lung Cancer 1997;18, suppl 1:236. Hillerdal G. Mesothelioma: cases associated with non-occupational and low dose exposures. Occup Environ Med 1999;56: Dodson RF et al. Tissue burden of asbestos in nonoccupationally exposed individuals from East Texas. Am J Ind Med 1999;35: Dodson RF et al. Asbestos content of omentum and mesentery in nonoccupationally exposed individuals. Toxicol Ind Health 2001;17: Dodson RF et al. Quantitative analysis of asbestos burden in women with mesothelioma. Am J Ind Med 2003;43: Sinninghe Damste HEJ et al. Environmental exposure to asbestos in the area around Goor established as a cause of pleural mesothelioma in women. Neth J Med 2007;151: Goldberg M. Luce D. The health impact of nonoccupational exposure to asbestos: What do we know? European J Cancer Prevention Lemen RA. Section in Chapter 5 on Take Home and Community Exposures to Asbestos. In: Asbestos: Risk Assessment, Epidemiology, and Health Effects, 2nd ed. Dodson RA, Hammar SP (eds.). CRC Press/Taylor & Francis Group 2011: Familial Exposure to Asbestos (List of 50 references) Familial Exposure to Asbestos: Citations and Summary Fiber Burden Dodson RF, et al. Asbestos fiber length as related to potential pathogenicity: a critical review. Am J Ind Med 2003;44: Dodson RF. Analysis and relevance of asbestos burden in tissue. In: Asbestos: Risk assessment, epidemiology, and health effects, 2nd ed. Dodson RF, Hammar SP (Eds). Boca Raton: CRC Press/Taylor Francis 2011: Page 6 of 51

7 Kohyama N, Suzuki Y. Analysis of asbestos fibers in lung parenchyma, pleural plaques, and mesothelioma tissues of North American Insulation Workers. Ann NY Acad Sci 1991;643: Suzuki Y, Yuen SR. Asbestos tissue burden study on human malignant mesothelioma. Ind Health 2001;39: Suzuki Y, Yuen SR. Asbestos fibers contributing to the induction of human malignant mesothelioma. Ann N Y Acad Sci 2002;982: Suzuki Y, Yuen SR, Ashley R. Short, thin asbestos fibers contribute to the development of human malignant mesothelioma: pathological evidence. Int J Hyg Environ Health 2005;208: Genetic Alterations Jaurand M-C. Asbestos, chromosomal deletions and tumor suppressor gene alterations in human malignant mesothelioma. Lung Cancer 2006;54 (Supp 1):S15;#59. Robbins and Cotran Pathologic Basis of Disease, 8 th ed. Molecular Basis of Cancer, pages Genetic Susceptibility Neri M, Ugolini D, Dianzani I, et al. Genetic susceptibility to malignant pleural mesothelioma and other asbestos-associated diseases. Mutat Res 2008;659: Kukkonen MK, Hamalainen S, Kaleva S, et al. Genetic susceptibility to asbestos-related fibrotic pleuropulmonary changes. Eur Respir J 2011;38: Governmental and Other Agencies Concerning No Safe Level NIOSH, 1976 (page 92): excessive cancer risks have been demonstrated at all fiber concentrations studied to date. Evaluation of all available human data provides no evidence for a threshold or a safe level of asbestos exposure. NIOSH, 1980 (page 3): All levels of asbestos exposure studied to date have demonstrated asbestos related disease there is no level of exposure below which clinical effects do not occur. USPHS, 1980: It is important to point out that when a permissible level for exposure (PEL) to a certain carcinogen is set by OSHA, there is no implication that such a level is safe. To the contrary, it is the agency s policy that any occupational exposure to a carcinogen carries with it some risk of disease, even if it cannot be easily or precisely measured. NIOSH, 1986 (page 319): a linear, no threshold, dose-response relationship Any asbestos exposure carries with it some increased risk of asbestos related disease. OSHA, 1994 (page 40978): reducing exposure to 0.1 f/cc would further reduce, but not eliminate, significant risk. The 0.1 f/cc level leaves a remaining significant risk. WHO, 1998 (page 144): Exposure to chrysotile asbestos poses increased risks for asbestosis, lung cancer and mesothelioma in a dose-dependent manner. No threshold has been identified for Page 7 of 51

8 carcinogenic risks. WTO, 2000: the experts confirm the position of the European Communities according to which it has not been possible to identify any threshold below which exposure to chrysotile would have no effect. The experts also agree that the linear relationship model, which does not identify any minimum exposure threshold, is appropriate for assessing the existence of a risk. We find therefore that no minimum threshold level of exposure or duration of exposure has been identified with regard to the risk of pathologies associated with chrysotile, except for asbestosis. IARC Special Report: Policy. A review of human carcinogens-part C: metals, arsenic, dusts, and fibres. Volume 10 May 2009 IARC 2012, Volume 100C. Asbestos (chrysotile, amosite, crocidolite, tremolite, actinolite, and anthophyllite). Joint Policy Committee Societies of Epidemiology. Position statement on asbestos from the Joint Policy Committee of the Societies of Epidemiology (JPC-SE); June 4, se.org/documents/01.jpc-se-position_statement_on_asbestos-june_4_2012- Summary_and_Appendix_A_English.pdf Historical Lynch KM, Smith WA. Pulmonary asbestosis III: Carcinoma of the lung in asbesto-silicosis. Am J Cancer 1935;24: Wedler HW. Uber den Lungenkrebs bei Asbestose. Dtsch Arch Klin Med 1943;191: Mallory TB, Castleman B, Harris EE. Case records of the Massachusetts General Hospital # N Eng J Med 1947;236: Merewether ERA. Annual report of the Chief Inspector of Factories for the year London: His Majesty s Stationery Office 1949: Editorial: Asbestosis and cancer of the lung. JAMA 1949;140: Doll R. Mortality from lung cancer in asbestos workers. Br J Ind Med 1955;12: McCaughey WTE. Primary Tumours of the Pleura. J Path Bact 1958;76: Wagner JC, Sleggs CA, Marchand P. Diffuse pleural mesothelioma and asbestos exposure in the North Western Cape Province. Br J Ind Med 1960;17: Selikoff IJ, Churg J, Hammond EC. The occurrence of asbestosis among insulation workers in the United States. Ann NY Acad Sci 1965;132: IMIG Consensus Statement Guidelines for pathologic diagnosis of malignant mesothelioma: a consensus statement from the International Mesothelioma Interest Group. Arch Lab Path Med 2009;133: Page 8 of 51

9 Guidelines for pathologic diagnosis of malignant mesothelioma: 2012 update of the consensus statement from the International Mesothelioma Interest Group. Arch Pathol Lab Med 2013;137(5): Low Level Exposure Hillerdal G. Mesothelioma: cases associated with non-occupational and low dose exposures. Occup Environ Med 1999;56: Hodgson JT, Darnton A. The quantitative risk of mesothelioma and lung cancer in relation to asbestos exposure. Ann Occup Hyg 2000;44: ; specifically, Table 11, page 585. Hodgson JT, Darnton A. Mesothelioma risk from chrysotile. Occup Environ Med Iwatsubo Y, Pairon JC, Boutin C, et al. Pleural mesothelioma: dose-response relation at low levels of asbestos exposure in a French population-based case-control study. Am J Epidem 1998;148: Rödelsperger K, Jöckel KH, Pohlabein H, et al. Asbestos and man-made vitreous fibers as risk factors for diffuse malignant mesothelioma: Results from a German hospital-based case-control study. Am J Ind Med 2001;39: Rolland P, Ducamp S, Gramond C, et al. Risk of pleural mesothelioma: A French population-based casecontrol study ( ). Lung Cancer 2006;54:S9(35). Sinninghe Damste HE, Siesling S, Burdorf A. Environmental exposure to asbestos in the area around Goor established as a cause of pleural mesothelioma in women. Neth J Med 2007;151: (see page 2456 re 0.11 fiber/cc years). De Matteis S, et al. Impact of occupational carcinogens on lung cancer risk in a general population. Int J Epidemiol 2012;41: PEL Federal Register 1986, Part II: Depart of Labor, Occupational Safety and Health Administration, 29 CFR Parts 1910 and 1926: Occupational exposure to asbestos, tremolite, anthophyllite & actinolite. Final Rules, pages ; specifically, Table 6 on page OSHA asbestos PELs and risk. by Tom Laubenthal and forwarded from Dodson to Hammar Translocation Dodson et al. Asbestos in extrapulmonary sites: omentum and mesentery. Chest 2000;117: Suzuki Y, Kohyama N. Translocation of inhaled asbestos fibers from the lung to other tissues. Am J Ind Med 1991;19: Heller DS et al. Asbestos exposure and ovarian fiber burden. Am J Ind Med 1996;29: Page 9 of 51

10 Tumorigenesis Weinberg RA. Chapter 11 - Multistep Tumorigenesis. In: The Biology of Cancer. New York: Garland Science, Taylor & Francis Group LLC 2007: Alpha by Author Cullen Cullen MR, Baloyi RS. Chrysotile asbestos and health in Zimbabwe: I. Analysis of miners and millers compensated for asbestos-related diseases since independence (1980). Am J Ind Med 1991;19: Cullen MR, et al. Predictors of lung cancer among asbestos-exposed men in the beta-carotene and Retinol efficacy trial. Am J Epidemiol 2005;161: Dodson Dodson RF, Williams MG, Corn CJ, et al. Asbestos content in lung tissue, lymph nodes and pleural plaques from former shipyard workers. Am Rev Respir Dis 1990;142: Dodson RF, Williams MG, Corn CJ et al. A comparison of asbestos burden in lung parenchyma, lymph nodes, and plaques. Ann NY Acad Sci 1991;643; Dodson RF, O Sullivan M, Corn CJ, McLarty JW, Hammar SP. Analysis of asbestos fiber burden in lung tissue from mesothelioma patients. Ultrastruct Pathol 1997;21: Dodson RF et al. Tissue burden of asbestos in nonoccupationally exposed individuals from East Texas. Am J Ind Med 1999;35: Dodson RF et al. Asbestos in extrapulmonary sites: omentum and mesentery. Chest 2000;117: Dodson RF, O Sullivan M, Brooks DR, Bruce JR. Asbestos content of omentum and mesentery in nonoccupationally exposed individuals. Toxicol Ind Health 2001;17: Williams MG, Dodson RF, Dickson EW, Fraire AE. An assessment of asbestos body formation in extrapulmonary sites: liver and spleen. Toxicology and Industrial Health 2001;17:1-6. Dodson RF, Williams MG, Satterley JD. Asbestos burden in two cases of mesothelioma where the work history included manufacturing of cigarette filters. J Toxicol Environ Health 2002;65: Dodson RF, et al. Asbestos fiber length as related to potential pathogenicity: a critical review. Am J Ind Med 2003;44: Dodson RF, et al. Quantitative analysis of asbestos burden in a series of individuals with lung cancer and a history of exposure to asbestos. Inhal Toxicol 2004;16: Dodson RF, Hammar SP. Pleural mesothelioma in a woman whose documented past exposure to asbestos was from smoking asbestos-containing filtered cigarettes. Inhal Toxicol 2006;18: Page 10 of 51

11 Dodson RF. Analysis and relevance of asbestos burden in tissue. In: Asbestos: Risk assessment, epidemiology, and health effects. Dodson RF, Hammar SP (eds). CRC Press/Taylor Francis Dodson RF, et al. Asbestos concentration in lung and lymph nodes as compared to asbestos concentration in various levels of lymph nodes that collect drainage from the lung. Ultrastruct Pathol 2007;31: Dodson RF, Hammar SP, Poye LW. A technical comparison of evaluating asbestos concentration by PCM, SEM, and ATEM as illustrated from data generated from a case report. Inhalation Toxicology 2008;20: Dodson RF, Hammar SP, Poye LW. Mesothelioma in an individual following exposure to crocidolitecontaining gaskets as a teenager. Int J Occup Environ Health 2011;17: Egilman Egilman D, et al. Exposing the myth of ABC, Anything but Chrysotile. Am J Ind Med 2003;44: Letters to the Editor. Egilman s response re Controlled Use of Asbestos. Am J Occup Env Health Egilman DS, Billings MA. Abuse of epidemiology: automobile manufacturers manufacture a defense to asbestos liability. Int J Occup Environ Health 2005;11: Letters to the Editor. Egilman s response re Setting the Record Straight. Int J Occup Environ Health Egilman D, Howe S. Against anti-health epidemiology: corporate obstruction of public health via manipulation of epidemiology. Int J Occup Environ Health 2007;13: Egilman D. Fiber types, asbestos potency, and environmental causation: a peer review of published work and legal and regulatory scientific testimony. Int J Occup Environ Health 2009;15: Egilman D, Menendez LM. A case of occupational peritoneal mesothelioma from exposure to tremolitefree chrysotile in Quebec, Canada: A black swan case. Am J Ind Med 2011;54: (Epub 2010). Hammar (also see CV) Dail and Hammar s Pulmonary Pathology, 3rd Ed. New York: Springer, 2008 Chapter 27 (volume I) Asbestos. Hammar SP, Dodson RF. Pages Chapter 43 (volume II) Neoplasms of the Pleura. Hammar SP, Henderson DW, Klebe S, Dodson RF. Pages Asbestos: Risk Assessment, Epidemiology, and Health Effects, 2nd ed. Boca Raton: CRC Press/Taylor & Francis Group, Page 11 of 51

12 Chapter 7: Asbestos and mesothelioma by Hammar SP. Chapter 8: Asbestos and other cancers by Hammar SP, Lemen RA, Henderson DW, Leigh J. Chapter 9: Asbestosis by Hammar SP. Chapter 10: Asbestos-induced pleural disease by Hammar SP. Chapter 11: Uncommon nonmalignant asbestos- induced conditions by Hammar SP. Hammar Affidavit re asbestos and mesothelioma updated Hammar Affidavit re asbestos and lung cancer updated Hammar Affidavit re asbestos and joint compounds updated Hammar Affidavit re pathologic grading of asbestosis updated Hammar Affidavit re autopsies and fiber burden analysis updated Hammar Affidavit re what is considered significant exposure to asbestos? Updated Heller Heller DS, Gordon RE, Westhoff C, Gerber S. Asbestos exposure and ovarian fiber burden. Am J Ind Med 1996;29: Henderson Henderson DW, et al. Lymphohistiocytoid mesothelioma: a rare lymphomatoid variant of predominantly sarcomatoid mesothelioma. Ultrastructural Pathol 1988;12: Henderson DW, Roggli VL, Shilkin KB, Hammar SP, Leigh J. Is asbestosis an obligate precursor for asbestos-induced lung cancer? Chapter 4. In: Asbestos Health Effects, Treatment and Control. Peters GA, Peters BJ (eds). The Michie Company; 1995; Henderson DW, et al. Asbestos and lung cancer: is it attributable to asbestosis or to asbestos fiber burden? In: Pathology of Lung Tumors. Corrin B (ed). Churchill Linvinstone 1997; WTO March 12, European communities measures affecting asbestos and asbestos-containing products. Henderson DW. Friction products (e.g. brake linings). WT/DS135/AB/R, pages Henderson DW, Rodelsperger K Woitowitz H-J, Leigh J. After Helsinki: a multidisciplinary review of the relationship between asbestos exposure and lung cancer, with emphasis on studies published during Pathology 2004;36: Henderson DW, Leigh J. Chapter 1 - The history of asbestos utilization and recognition of asbestosinduced diseases. In: Asbestos: Risk assessment, epidemiology, and health effects, 2nd ed. Dodson RF, Hammar SP (eds.). Boca Raton/London/New York: CRC Press/Taylor Francis 2011:1-22. Page 12 of 51

13 Klebe S, Henderson DW. Chapter 4 - The molecular pathogenesis of asbestos-related disorders. In: Asbestos risk assessment, epidemiology, and health effects, 2nd ed. Dodson RF, Hammar SP (eds.). Boca Raton/London/New York: CRC Press/Taylor Francis 2011: Henderson DW. Leigh J. Chapter 6 - Asbestos and carcinoma of the lung. In: Asbestos risk assessment, epidemiology, and health effects, 2 nd ed. Dodson RF, Hammar SP (eds.). Boca Raton/London/New York: CRC Press/Taylor Francis 2011: Hammar SP, Lemen RA, Henderson DW, Leigh J. Chapter 8 - Asbestos and other cancers. In: Asbestos risk assessment, epidemiology, and health effects, 2 nd ed. Dodson RF, Hammar SP (eds.). Boca Raton/London/New York: CRC Press/Taylor Francis 2011: Henley Henley SJ, Larson TC, Wu M, et al. Mesothelioma incidence in 50 states and the District of Columbia, United States, Int J Occup Environ Health 2013;19:1-10. Hillerdal Hillerdal G, Henderson DW. Asbestos, asbestosis, pleural plaques and lung cancer. Scand J Work Environ Health 1997;23: Hillerdal G. Mesothelioma: cases associated with non-occupational and low dose exposures. Occup Environ Med 1999;56: Hodgson and Darnton Hodgson JT, Darnton A. The quantitative risks of mesothelioma and lung cancer in relation to asbestos exposure. Ann Occup Hyg 2000;44: Hodgson JT, Darnton A. Mesothelioma risk from chrysotile. Occup Environ Med Iwatsubo Iwatsubo Y, Pairon JC, Boutin C, et al. Pleural mesothelioma: dose-response relation at low levels of asbestos exposure in a French population-based case-control study. Am J Epidemiol 1998;148: Langer and Nolan Langer AM, Nolan RP. Chrysotile biopersistence in the lungs of persons in the general population and exposed workers. Environ Health Perspect 1994;102: Langer AM, Nolan RP. Asbestos in the lungs of persons exposed in the USA. Monaldi Arch Chest Dis 1998;53: Leigh Rogers AJ, Leigh J, Berry G, et al., Relationship between lung asbestos fiber type and concentration and relative risk of mesothelioma, a case-control study. Cancer 1991;67: Leigh J, et al. Malignant mesothelioma in Australia, Am J Ind Med 2002;41: Letter from Dr. James Leigh to the US EPA dated 10/1/03. Page 13 of 51

14 Hammar SP, Lemen RA, Henderson DW, Leigh J. Chapter 8 - Asbestos and other cancers. In: Asbestos risk assessment, epidemiology, and health effects, 2 nd ed. Dodson RF, Hammar SP (eds.). Boca Raton/London/New York: CRC Press/Taylor Francis 2011: Lemen Lemen RA. Dement JM, Wagoner JK. Epidemiology of asbestos-related diseases. Environ Health Perspect 1980;34:1-11. Lemen RA. Asbestos in brakes: Exposure and risk of disease. Am J Ind Med 2004;45: Lemen RA. Chrysotile asbestos as a cause of mesothelioma: application of the Hill causation model. Int J Occup Environ Health 2004;10: Lemen RA. Chapter 5 - Epidemiology of Asbestos-related Diseases and the Knowledge that Led to What is Known Today. In: Dodson RF, Hammar SP (Eds.), Asbestos: Risk Assessment, Epidemiology, and Health Effects, 2nd ed. CRC/Taylor & Francis, 2011: Hammar SP, Lemen RA, Henderson DW, Leigh J. Chapter 8 - Asbestos and other cancers. In: Asbestos risk assessment, epidemiology, and health effects, 2 nd ed. Dodson RF, Hammar SP (eds.). Boca Raton/London/New York: CRC Press/Taylor Francis 2011: Stayner L, Welch LS, Lemen R. The worldwide pandemic of asbestos-related diseases. Annu Rev Public Health 2013;34: Nicholson Nicholson WJ. Comparative dose-response relationships of asbestos fiber types: magnitudes and uncertainties. Ann N Y Acad Sci 1991;643: Nicholson WJ. The carcinogenicity of chrysotile asbestos-a review. Ind Health 2001;39: Ordónez Ordonez NG. Mesothelioma with clear cell features: an ultrastructural and immunohistochemical study of 20 cases. Hum Pathol 2005;36(5): Ordonez NG. D2-40 and podoplanin are highly specific and sensitive immunohistochemical markers of epithelioid malignant mesothelioma. Hum Pathol 2005;36(4): Ordonez NG. Value of immunohistochemistry in distinguishing peritoneal mesothelioma from serous carcinoma of the ovary and peritoneum: a review and update. Adv Anat Pathol 2006;13(1): Ordonez NG. The diagnostic utility of immunohistochemistry in distinguishing between epithelioid mesotheliomas and squamous carcinomas of the lung: a comparative study. Mod Pathol 2006;19(3): Page 14 of 51

15 Ordonez NG. Mesothelioma with rhabdoid features: an ultrastuctural and immunohistochemical study of 10 cases. Mod Pathol 2006;19(3): Ordonez NG. What are the current best immunohistochemical markers for the diagnosis of epithelioid mesothelioma: a review and update. Hum Pathol 2007;38(1):1-16. Ordonez NG. Deciduoid mesothelioma: report of 21 cases with review of the literature. Mod Pathol 2012;25(11): Ordonez NG. Pleomorphic mesothelioma: report of 10 cases. Mod Pathol 2012;25(7): Ordonez NG. Mesotheliomas with small cell features: report of eight cases. Mod Pathol 2012;25(5): Ordonez NG. Mesotheliomas with crystalloid structures: report of nine cases, including one with oncocytic features. Mod Pathol 2012;25(2): Ordonez NG. Value of PAX8, PAX2, napsin A, carbonic anhydrase IX, and claudin-4 immunostaining in distinguishing pleural epithelioid mesothelioma from metastatic renal cell carcinoma. Mod Pathol 2013 March 15. doi: /modpathol Ordonez NG. Mesothelioma with signet-ring cell features: report of 23 cases. Mod Pathol 2013;26: doi: /modpathol ; published online 5 October Ordonez NG. Application of immunohistochemistry in the diagnosis of epithelioid mesothelioma: a review and update. Hum Pathol 2013;44(1):1-19. doi: /j.humpath Ordonez NG. Value of claudin-4 immunostaining in the diagnosis of mesothelioma. Am J Clin Pathol 2013;139: Reid and de Klerk Reid A, de Klerk N, et al. The effect of asbestosis on lung cancer risk beyond the dose related effect of asbestos alone. Occup Environ Med 2005;62: Rodelsperger Rödelsperger K, Jahn H, Bruckel B, et al. Asbestos dust exposure during brake repair. Am J Ind Med 1986;10: Rödelsperger K, Jockel K-H, Pohlabein H, et al. Asbestos and man-made vitreous fibers as risk factors for diffuse malignant mesothelioma: Results from a German hospital-based case-control study. Am J Ind Med 2001;39: Rolland Rolland P, Ducamp S, Gramond C, et al. Risk of pleural mesothelioma: A French population-based casecontrol study ( ). Lung Cancer 2006;54:S9(35). Page 15 of 51

16 Rolland P, Gramond C, Lacourt A, et al. Occupations and industries in France at high risk for pleural mesothelioma: A population-based case-control study ( ). Am J Ind Med Lacourt A, Rolland P, Gramond C, et al. Attributable risk in men in two French case-control studies on mesothelioma and asbestos. Eur J Epidemiol Saracci Saracci R. The interaction of tobacco smoking and other agents in cancer etiology. Epidemiol Rev 1987; 9: Selikoff Selikoff IJ, Hammond EC, Churg J. Asbestos exposure, smoking, and neoplasia. JAMA1968;204: Selikoff IJ, Hammond EC, Seidman H. Mortality experience in insulation workers in the United States and Canada, Ann N Y Acad Sci 1979;330: Selikoff IJ, Lilis R, Levin G. Asbestotic radiological abnormalities among United States merchant marine seamen. Br J Ind Med 1990;47: Suzuki Suzuki Y, Kohyama N. Translocation of inhaled asbestos fibers from the lung to other tissues. Am J Ind Med 1991;19: Kohyama N, Suzuki Y. Analysis of asbestos fibers in lung parenchyma, pleural plaques, and mesothelioma tissues of North American insulation workers. Ann NY Academy of Sciences 1991;643: Suzuki Y, Yuen SR. Asbestos tissue burden study on human malignant mesothelioma. Ind Health 2001;39: Suzuki Y, Yuen SR. Asbestos fibers contributing to the induction of human malignant mesothelioma. Ann N Y Acad Sci 2002;982: Suzuki Y, Yuen SR, Ashley R. Short, thin asbestos fibers contribute to the development of human malignant mesothelioma: pathological evidence. Int J Hyg Environ Health 2005;208: Welch Welch LS, et al. Asbestos and peritoneal mesothelioma among college-educated men. Int J Occup Environ Health 2005;11: Welch LS. Asbestos exposure causes mesothelioma, but not this asbestos exposure: An amicus brief to the Michigan Supreme Court. Int J Occup Environ Health 2007;13: Page 16 of 51

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