Società Triveneta di Chirurgia Aviano, 25 Febbraio 2012
|
|
|
- Maximillian Waters
- 8 years ago
- Views:
Transcription
1 Società Triveneta di Chirurgia Aviano, 25 Febbraio 2012 Carcinoma Gastrico Localmente Avanzato:Terapie Integrate Progetto NEOX-RT Antonino De Paoli UO Oncologia Radioterapica, CRO Aviano
2 Gastric Cancer - Current Issues Changing epidemiology (diagnosis and treatment implications) Curative surgery (mainstay of treatment) Adjuvant chemotherapy (still controversial) Adjuvant chemoradiation (possible benefit) Perioperative chemotherapy (possible benefit)
3 Neo-adjuvant and adjuvant therapy for gastric cancer: different strategies Post-operative Chemoradiotherapy (trend to preoperative CT-RT in academic centers) Peri-operative Chemotherapy (ECF- 5FU/cisplatin) Postoperative CT Post-operative Chemotherapy (S-1 or combination)
4 Ongoing Trials US (Intergroup Trial) Post-op 5FU/LV + RT/5FU vs ECF + RT/5FU (Does ECF improve efficacy of post-op CRT?) EU Periop ECX vs Periop ECX-BEV (Is there a role of biologics?) (MAGIC-B) Preop ECX-Surg-postop ECX vs RT/X-DDP (CRITICS) (What is the role of postop CT-RT?) Preop ECX x3 vs ECX x2-rt/x+postop ECX (EORTC) (What is the role of preop CT-RT?) Japan Adjuvant S1 vs Surgery alone
5 Cosa fare nella pratica clinica T3 N0 T2/3/4 N+ no terapia terapia con 5FU, o ECF o CDDP, de Gramont MitC. Se chirurgia inadeguata (Lfn <15 LN, R1) RT-CT Se chirurgia adeguata, ma elevato N-ratio (>25%) RT-CT Cascinu S - IRST Meldola, 2010
6 Japanese Research Society for Gastric Cancer 1 right paracardium 2 left paracardium 3 lesser curvature 4 greater curvature 5 suprapylorum 6 infrapylorum 7 left gastric artery 8 common hepatic artery 9 celiac artery 10 splenic hilum 11 proximal splenic artery 12 hepatoduodenal ligament (a,b,p) 13 posterior surface of the pancreatic head 14 superior mesenteric vessels 15 middle colic vessels 16 abdominal aorta
7 b+p 5 12 b+p b+p b
8
9 PostOp RT-CT Toxicity Macdonald 281 pts % Korean 544 pts % Italian pool 348 pts % RT-CT compliance G3 Acute Tox G4 Acute Tox Macdonald JS et al NEJM Kim S et al IJROBP 2005 Mattiucci GCet al ESTRO- 2010
10 CENTRI PARTECIPANTI Varese Ivrea Siena Firenze Firenze S.M. Annunziata Arezzo Viterbo Roma UCSC Aviano Trieste Padova Meldola Ancona Perugia Chieti S.G.Rotondo Barletta Rionero in Vulture Taranto AIRO-GI Working Group
11 Ongoing Trials Italy ITACAS-2 Phase III Study Periop vs post-op EOX and assessment of benefit of post-op RT/Cape DOX Phase II randomised Study Periop DOX vs Preop DOX NEOX-RT Phase II Study Preop EOX + RT/OX
12 ITACA-S 2 (Intergroup Trial in Adjuvant Chemotherapy for Adenocarcinoma of the Stomach 2): Comparison of the efficacy of a peri-operative versus a post-operative chemotherapy treatment in patients with operable gastric cancer and assessment of the benefit of a post-operative chemo-radiotherapy Sponsor: Istituto di Ricerche Farmacologiche Mario Negri Supported by: AIFA Medical Oncology: Francesco Di Costanzo (P.Investigator) Radiation Oncology: Vincenzo Valentini Surgery: Donato Nitti STUDIO ITACA-S 2
13 Disegno dello Studio MAGIC ITACA-S1 CRITICS INT-0116
14 Preoperative Chemoradiotherapy in Castric Cancer- The MD Anderson. experience Post-op mortality: 5.6% vs 5.9% Post-op morbility: 46% vs 45% Post-op hosp stay (med): 13 d vs 13 d MAGIC data, NEJM 2006 pcr: 23% - R0 Rate: 95% Post Op Compl: 38% Post Op Death: 2.8% Fujitani K et al Ann Surg Oncol 2007 Reed VK et al IJROBP 2008
15
16
17 Neoadjuv ChemoRT in Gastric Cancer The risk of tumour progression MDACC 9/41 (22%) not resected for PD at surgery Magic trial 37/209 (18%) not resected for PD at surgery German trial 12/119 (10%) not resected for PD at surgery Ajani JA et Al JCO 2005 Cunningham et Al - NEJM 2006 Sthal M et al- JCO-2009
18 The L shape survival curve of Gastric Cancer INT-0116 Magic D2 = 10% D2 = 40% Valentini V et al, Tumori 2008
19 NEOX-RT Study NEOADJUVANT EPIRUBICIN-OXALIPLATIN-XELODA AND OXALIPLATIN-XELODA RADIOTHERAPY IN LOCALLY ADVANCED, RESECTABLE, GASTRIC CANCER A PHASE II COLLABORATIVE STUDY Actived March 2009
20 NEOX-RT Study Patients with locally advanced ut3-4,n0 or any ut,n+m0(lps) potentially resectable, EGJ(II-III)-Gastric Cancer Induction chemotherapy Patients with early metabolic disease progression (CT- PET) will undergo to immediate surgery Chemoradiotherapy Surgery Week 22 EOX x 3 cycles (q 3weeks) for 9 weeks RT 45 Gy + Oxaliplatin-Xeloda for 5 weeks Responding pts CT-PET evaluation after 2 cycles EOX Objective Response (Endoscopy/EUS) after 9 weeks Restaging CT-PET CT abdomen and chest Objective Response (Endoscopy/EUS) after 4 weeks from CT-RT SURGERY +/- IORT 4-6 weeks after chemoradiotherapy Path Response Rate R0 Resection Rate Treat Compliance
21 NEOX-RT Study Pre-Op CT EOX x 3 Pre-Op CT-RT OX + 45Gy (+/-CB) Surgery +/-IORT D2 10 Gy weeks CT-PET CT-PET CT-PET Tissue banking Nutritional monitoring and support Quality of Life Epirubicin 50 mg/m2 d1 3D-CRT 45Gy/25fr +/- 10Gy/10fr, 2 weekly Oxaliplatin 130mg/m2 d1 Oxaliplatin 30mg/m2, weekly Xeloda 625mg/m2 bid d1-21 Xeloda 625mg/m2, bid, d1-35
22 Use the following general planning guidelines for therapy Prerequisite Presumed loco-regional cancer Step N Procedure 1 Clinical staging and Endoscopic Ultrasound, CT-PET Non-metastatic cancer 2 Laparoscopy and peritoneal staging No peritoneal cancer and eligibility criteria fulfilled Completed preoperative chemotherapy (if CT- PET responsive) Completed preoperative chemoradiotherapy 3 Get consent, register and start preoperative Chemotherapy 4 Rest 2 weeks then start preoperative Chemoradiotherapy 5 Rest 4-5 weeks then proceed with preoperative work-up Non-metastatic cancer 6 Attempt Surgery +/-IORT Completed all therapy 7 Follow-up for 5 years or until death
23 NEOX-RT Study - Investigator Study Coordinator Mario Lise Centro di Riferimento Oncologico, Aviano Board Chair Investigators Surgeon Domenico D Ugo Università Cattolica S.Cuore, Roma Francesco De Marchi Centro di Riferimento Oncologico, Aviano Radiation Oncologist Antonino De Paoli Centro di Riferimento Oncologico, Aviano Medical Oncologist Carlo Barone Università Cattolica S.Cuore, Roma Donato Nitti Università di Padova Alberto Marchet Università di Padova, Padova Vincenzo Valentini Università Cattolica S.Cuore, Roma Sergio Frustaci Centro di Riferimento Oncologico, Aviano Data management Clinical Trial Office Centro di Riferimento Oncologico, Aviano
24 NEOX-RT Centri Partecipanti CRO-Aviano Ospedale Pordenone Ospedale S.Vito Ospedale Spilimbergo Ospedale Portogruaro UniversitàPD-IOV UCSC Roma SFN Roma Ospedale Trento Onc Chir, OncMed, OncRad I Chir, II Chir, Onc Med Chir, Onc Med Chir, Onc Med Chir, Onc Med II Clin Chir, OncMed, RadOnc I Clin Chir, OncMed,RadOnc Chir, OncMed, RadOnc I Chir, II Chir, OncMed, RadOnc
25 Statistical considerations and Sample Size Primary end-point: pcr (all entered patients) Sample size: 49 patients pcr difference 15% (p0=5%; p1=20%) I Step 21 patients; if >1pCR, II Step 20 patients. Overall 41 patients; if 85% path asssessed, TOTAL 49 patients Simon s two stage design
26 NEOX-RT Accrual 3-09 to Patients accrued: 18 Completed Preop Program: 13 Ongoing Preop Program: 3 Underwent to Surgery: 14 (2pCR) 1 patient had emergency operation (bleeding) 1 patient drop-out (refusal) 1 patient had postop complication (re-operation) CRO 2008
27
Adiuwantowe i neoadiuwantowe leczenie chorych na zaawansowanego raka żołądka
Adiuwantowe i neoadiuwantowe leczenie chorych na zaawansowanego raka żołądka Neoadiuvant and adiuvant therapy for advanced gastric cancer Franco Roviello, IT Neoadjuvant and adjuvant therapy for advanced
Stomach (Gastric) Cancer. Prof. M K Mahajan ACDT & RC Bathinda
Stomach (Gastric) Cancer Prof. M K Mahajan ACDT & RC Bathinda Gastric Cancer Role of Radiation Layers of the Stomach Mucosa Submucosa Muscularis Serosa Stomach and Regional Lymph Nodes Stomach and Regional
Locally advanced and bordeline forms of pancreatic cancer
19 May 2011 Locally advanced and bordeline forms of pancreatic cancer P r Pascal Hammel Pôle des Maladies de l Appareil Digestif Hôpital Beaujon, 92110 Clichy Université Paris VII, Denis Diderot pascal.hammel@bjn.aphp.fr
Principles of Radiation Therapy A Bapsi Chakravarthy, MD Associate e P rofessor Professor Radiation Oncology
Principles of Radiation Therapy A Bapsi Chakravarthy, MD Associate Professor Radiation Oncology Disclosure Information I have no financial relationships to disclose relevant to the conten of this presentation.
TRATTAMENTO COMBINATO RADIO- CHEMIOTERAPICO NEL III STADIO NSCLC
TRATTAMENTO COMBINATO RADIO- CHEMIOTERAPICO NEL III STADIO NSCLC Dr.ssa Sara Ramella Radioterapia Oncologica Campus Bio-Medico Trimodality therapy offers a promising chance of long-term survival Evidenze
SAKK Lung Cancer Group. Current activities and future projects
SAKK Lung Cancer Group Current activities and future projects SAKK Lung Cancer Group Open group of physicians interested in lung cancer Mostly Medical Oncologists, but also Thoracic Surgeons Radiation
Pancreatic Cancer: FDA Approved Treatments and Clinical Trials
Pancreatic Cancer: FDA Approved Treatments and Clinical Trials Vincent J Picozzi MD MMM Virginia Mason Medical Center Seattle WA 1 Pancreatic cancer is the hardest cancer of all to treat 2 Pancreatic cancer:
Management of stage III A-B of NSCLC. Hamed ALHusaini Medical Oncologist
Management of stage III A-B of NSCLC Hamed ALHusaini Medical Oncologist Global incidence, CA cancer J Clin 2011;61:69-90 Stage III NSCLC Includes heterogeneous group of patients with differences in the
Evaluation of perioperative chemotherapy for operable gastroesophageal and gastric cancer In western Denmark June 2008- August 2010
Evaluation of perioperative chemotherapy for operable gastroesophageal and gastric cancer In western Denmark June 2008- August 2010 Anders Christian Larsen,md. Phd student Department of Surgery and Oncology
Non-Small Cell Lung Cancer Treatment Comparison to NCCN Guidelines
Non-Small Cell Lung Cancer Treatment Comparison to NCCN Guidelines April 2008 (presented at 6/12/08 cancer committee meeting) By Shelly Smits, RHIT, CCS, CTR Conclusions by Dr. Ian Thompson, MD Dr. James
The evolution of rectal cancer therapy. Objectives
The evolution of rectal cancer therapy Hagen Kennecke MD MHA FRCPC Western Canada Consensus Conference September 5, 2014 Objectives Identify standard therapy: stage II/III rectal cancer Update recent adjuvant
Integrating Chemotherapy and Liver Surgery for the Management of Colorectal Metastases
I Congresso de Oncologia D Or July 5-6, 2013 Integrating Chemotherapy and Liver Surgery for the Management of Colorectal Metastases Michael A. Choti, MD, MBA, FACS Department of Surgery Johns Hopkins University
Neoadjuvant therapy are we doing it right? Short course and chemoradiation
Neoadjuvant therapy are we doing it right? Short course and chemoradiation Rob Glynne-Jones Mount Vernon Cancer Centre Relevant Endpoints in rectal cancer Local recurrence Disease-free survival Overall
Approccio multidisciplinare nei tumori del retto
Approccio multidisciplinare nei tumori del retto F. Muñoz Radiation Oncology Department University of Torino, Italy RECENT CHANGES IN RECTAL CANCER DIAGNOSIS AND THERAPY Optimal staging by EUS and MRI
What is the reference cytotoxic regimen in advanced gastric cancer?
What is the reference cytotoxic regimen in advanced gastric cancer? Florian Lordick Professor of Oncology Director of the University Cancer Center Leipzig (UCCL) Germany What we know from clinical research.
Laura Biganzoli Oncologia Medica Nuovo Ospedale di Prato Istituto Toscano Tumori
EFFECT: A randomized phase II study to evaluate the EFficacy and impact on Function of two different doses of nabpaclitaxel in elderly patients with advanced breast cancer Laura Biganzoli Oncologia Medica
Rectal Cancer. To Radiate or not to radiate? Q: Should rectal cancer RT/CRT decisions be based solely on stage? 11/09/2014
Rectal Cancer To Radiate or not to radiate?? Dr. Corinne Doll Radiation Oncologist Tom Baker Cancer Centre Calgary, Alberta Q: Should rectal cancer RT/CRT decisions be based solely on stage? 1 Q: Can RT/CRT
Come è cambiata la storia naturale della malattia
Malattia Metastatica del Carcinoma del Grosso Intestino Tecniche e terapie Innovative Come è cambiata la storia naturale della malattia Antonio Frassoldati Oncologia Clinica - Ferrara 29 ottobre 2011 Colorectal
Table of Contents. Data Supplement 1: Summary of ASTRO Guideline Statements. Data Supplement 2: Definition of Terms
Definitive and Adjuvant Radiotherapy in Locally Advanced Non-Small-Cell Lung Cancer: American Society of Clinical Oncology Clinical Practice Guideline Endorsement of the American Society for Radiation
Radiotherapy in locally advanced & metastatic NSC lung cancer
Radiotherapy in locally advanced & metastatic NSC lung cancer Dr Raj Hegde. MD. FRANZCR Consultant Radiation Oncologist. William Buckland Radiotherapy Centre. Latrobe Regional Hospital. Locally advanced
Carcinoma of the Cervix. Kathleen M. Schmeler, MD Associate Professor Department of Gynecologic Oncology
Carcinoma of the Cervix Kathleen M. Schmeler, MD Associate Professor Department of Gynecologic Oncology Cervical Cancer Treatment Treatment Microinvasive (Stage IA1): Simple (extrafascial) hysterectomy/cone
Chemotherapy in Ovarian Cancer. Dr R Jones Consultant Medical Oncologist South Wales Gynaecological Oncology Group
Chemotherapy in Ovarian Cancer Dr R Jones Consultant Medical Oncologist South Wales Gynaecological Oncology Group Adjuvant chemotherapy for early stage EOC Fewer than 30% women present with FIGO stage
PANCREATIC AND PERIAMPULLARY TUMORS: PANCREATICODUODENECTOMY. Dr. Shailesh V. Shrikhande
PANCREATIC AND PERIAMPULLARY TUMORS: PANCREATICODUODENECTOMY Dr. Shailesh V. Shrikhande Associate Professor & Consultant Surgeon GI and HPB Surgical Oncology Tata Memorial Hospital, Mumbai INDIA HELICAL
Accelerated hemithoracic radiation followed by extrapleural pneumonectomy for malignant pleural mesothelioma
Accelerated hemithoracic radiation followed by extrapleural pneumonectomy for malignant pleural mesothelioma Marc de Perrot, Ronald Feld, Natasha B Leighl, Andrew Hope, Thomas K Waddell, Shaf Keshavjee,
Columbia University Mesothelioma Applied Research Foundation - 2009 - www.curemeso.org. Mesothelioma Center www.mesocenter.org
Columbia University Mesothelioma Center www.mesocenter.org Multimodal clinical trials, treatment (surgery, radiation, chemotherapy) Peritoneal mesothelioma program Immunotherapy translational, experimental
L Lang-Lazdunski, A Bille, S Marshall, R Lal, D Landau, J Spicer
Pleurectomy/decortication, hyperthermic pleural lavage with povidone-iodine and systemic chemotherapy in malignant pleural mesothelioma. A 10-year experience. L Lang-Lazdunski, A Bille, S Marshall, R Lal,
Targeted Therapy What the Surgeon Needs to Know
Targeted Therapy What the Surgeon Needs to Know AATS Focus in Thoracic Surgery 2014 David R. Jones, M.D. Professor & Chief, Thoracic Surgery Memorial Sloan Kettering Cancer Center I have no disclosures
Van Cutsem E et al. Proc ASCO 2009;Abstract LBA4509.
Efficacy Results from the ToGA Trial: A Phase III Study of Trastuzumab Added to Standard Chemotherapy in First-Line HER2- Positive Advanced Gastric Cancer Van Cutsem E et al. Proc ASCO 2009;Abstract LBA4509.
Mesothelioma. Malignant Pleural Mesothelioma
Mesothelioma William G. Richards, PhD Brigham and Women s Hospital Malignant Pleural Mesothelioma 2,000-3,000 cases per year (USA) Increasing incidence Asbestos (50-80%, decreasing) 30-40 year latency
Carcinoma rettale: ruolo della radioterapia
Carcinoma rettale: ruolo della radioterapia M.A.Gambacorta Cattedra di Radioterapia Università Cattolica del Sacro Cuore-Roma Is radiotherapy active? D 10 7 Gy Primary tumour Cells 10 10-12 Positive Nodes
A Practical Guide to Advances in Staging and Treatment of NSCLC
A Practical Guide to Advances in Staging and Treatment of NSCLC Robert J. Korst, M.D. Director, Thoracic Surgery Medical Director, The Blumenthal Cancer Center The Valley Hospital Objectives Revised staging
Corso Integrato di Clinica Medica ONCOLOGIA MEDICA AA 2010-2011 LUNG CANCER. VIII. THERAPY. V. SMALL CELL LUNG CANCER Prof.
Corso Integrato di Clinica Medica ONCOLOGIA MEDICA AA 2010-2011 LUNG CANCER. VIII. THERAPY. V. SMALL CELL LUNG CANCER Prof. Alberto Riccardi SMALL CELL LUNG CARCINOMA Summary of treatment approach * limited
La Chemioterapia Adiuvante Dose-Dense. Lo studio GIM 2. Alessandra Fabi
La Chemioterapia Adiuvante Dose-Dense Lo studio GIM 2 Alessandra Fabi San Antonio Breast Cancer Symposium -December 10-14, 2013 GIM 2 study Epirubicin and Cyclophosphamide (EC) followed by Paclitaxel (T)
Rotation Specific Goals & Objectives: University Health Network-Princess Margaret Hospital/ Sunnybrook Breast/Melanoma
Rotation Specific Goals & Objectives: University Health Network-Princess Margaret Hospital/ Sunnybrook Breast/Melanoma Medical Expert: Breast Rotation Specific Competencies/Objectives 1.0 Medical History
PATIENT INFORMATION ABOUT ADJUVANT THERAPY AFTER THE WHIPPLE OPERATION FOR ADENOCARCINOMA ( CANCER ) OF THE PANCREAS AND RELATED SITES.
PATIENT INFORMATION ABOUT ADJUVANT THERAPY AFTER THE WHIPPLE OPERATION FOR ADENOCARCINOMA ( CANCER ) OF THE PANCREAS AND RELATED SITES. Radiation Oncology Sidney Kimmel Cancer Center at Johns Hopkins Last
Small Cell Lung Cancer
Small Cell Lung Cancer Lung Practice Guideline Dr. Brian Dingle MSc, MD, FRCPC Approval Date: April 2007 Revised: November 2008 This guideline is a statement of consensus of the Thoracic Disease Site Team
The Royal Marsden. Surgery for Gastric and GE Junction Cancer: primary palliative where and when? William Allum
The Royal Marsden Surgery for Gastric and GE Junction Cancer: primary palliative where and when? William Allum Any surgeon can cure Surgeon - dependent No surgeon can cure EMR D2 GASTRECTOMY H N SN. WEDGE
SMALL CELL LUNG CANCER
Protocol for Planning and Treatment The process to be followed in the management of: SMALL CELL LUNG CANCER Patient information given at each stage following agreed information pathway 1. DIAGNOSIS New
Stereotactic Body Radiation Therapy for Locally Advanced and Borderline Resectable Pancreatic Cancer Is Effective and Well Tolerated
International Journal of Radiation Oncology biology physics www.redjournal.org Clinical Investigation: Gastrointestinal Cancer Stereotactic Body Radiation Therapy for Locally Advanced and Borderline Resectable
Evidence tabel Lokaal palliatieve behandelingen
Auteurs, jaartal Mate van bewijs Studie type Follow-up Populatie (incl. steekproef-grootte) Patienten kenmerken Interventie Controle Resultaten Conclusie Opmerkingen, commentaar Hartgrink, 2002 The Netherlands
Long-Term Survival After Multidisciplinary Management of Resected Pancreatic Adenocarcinoma
Ann Surg Oncol DOI 10.1245/s10434-008-0295-2 ORIGINAL ARTICLE HEPATOBILIARY AND PANCREATIC TUMORS Long-Term Survival After Multidisciplinary Management of Resected Pancreatic Adenocarcinoma Matthew H.
E UROPEAN CURRICULUM VITAE FORMAT
E UROPEAN CURRICULUM VITAE FORMAT PERSONAL INFORMATION Name Address VALENTINA GUARNERI University of Padova Dipartimento di Scienze Chirurgiche, Oncologiche e Gastroenterologiche Istituto Oncologico Veneto
Preoperative drainage is always indicated in malignant CBD strictures PRO. Horst Neuhaus Evangelisches Krankenhaus Düsseldorf, Germany
Preoperative drainage is always indicated in malignant CBD strictures PRO Horst Neuhaus Evangelisches Krankenhaus Düsseldorf, Germany Background Jaundice is associated with high perioperative morbidity
The Whipple Operation for Pancreatic Cancer: Optimism vs. Reality. Franklin Wright UCHSC Department of Surgery Grand Rounds September 11, 2006
The Whipple Operation for Pancreatic Cancer: Optimism vs. Reality Franklin Wright UCHSC Department of Surgery Grand Rounds September 11, 2006 Overview Pancreatic ductal adenocarcinoma Pancreaticoduodenectomy
Lung Cancer and Mesothelioma
Lung Cancer and Mesothelioma Robert Kratzke, M.D. John C. Skoglund Professor of Lung Cancer Research Section of Heme/Onc/Transplant Department of Medicine University of Minnesota Medical School Malignant
Gastric or gastroesophageal junction cancer, advanced, as first-line therapy in combination with fluoropyrimidine-based
COMPENDIA TRANSPARENCY TRACKING FORM DRUG: Cetuximab INDICATION: chemotherapy Gastric or gastroesophageal junction cancer, advanced, as first-line therapy in combination with fluoropyrimidine-based COMPENDIA
U.S. Food and Drug Administration
U.S. Food and Drug Administration Notice: Archived Document The content in this document is provided on the FDA s website for reference purposes only. It was current when produced, but is no longer maintained
Mesothelioma. 1. Introduction. 1.1 General Information and Aetiology
Mesothelioma 1. Introduction 1.1 General Information and Aetiology Mesotheliomas are tumours that arise from the mesothelial cells of the pleura, peritoneum, pericardium or tunica vaginalis [1]. Most are
Probe: Could you tell me about when?
PERIODIC ASSESSMENT OF TREATMENT AND VITAL/DISEASE STATUS Periodic Assessment of Cancer Treatment and Disease Status (To be administered to patient at 3 months and reviewed at 6, 9 and 12 months) Instructions:
Protein kinase C alpha expression and resistance to neo-adjuvant gemcitabine-containing chemotherapy in non-small cell lung cancer
Protein kinase C alpha expression and resistance to neo-adjuvant gemcitabine-containing chemotherapy in non-small cell lung cancer Dan Vogl Lay Abstract Early stage non-small cell lung cancer can be cured
Management of Stage III, N2 NSCLC: A Virtual Thoracic Oncology Tumor Board
Management of Stage III, N2 NSCLC: A Virtual Thoracic Oncology Tumor Board Abstract Introduction Management of stage III non small-cell lung cancer (NSCLC) is complex and requires careful work-up, staging,
Medical Billing and Patient Education - The Process
PATIENT EDUCATION AND EMPOWERMENT: THE EXPERIENCE OF AN ENLARGED WORKING GROUP? P. DE PAOLI for the Extending CCCs expertise in Patient Education: the power of partnership with patient representatives
Malignant Mesothelioma State of the Art
Malignant Mesothelioma State of the Art Paul Baas The Netherlands Cancer Institute August 12, 2011, Carlsbad, CA Summary Diagnosis; epithelial type subdivided Pleiomorphic vs other Staging: IASLC-IMIG
La personalizzazione terapeutica: quanto influisce l età
La personalizzazione terapeutica: quanto influisce l età PierFranco Conte University of Padova Department of Surgery, Oncology and Gastroenterology IOV Istituto Oncologico Veneto I.R.C.C.S. Breast Cancer
10 th EADO Congress Vilnius, 7-10 May 2014. Ipilimumab update. Michele Maio
10 th EADO Congress Vilnius, 7-10 May 2014 Ipilimumab update Michele Maio Medical Oncology and Immunotherapy, Department of Oncology University Hospital of Siena, Istituto Toscano Tumori SIENA, ITALY Evolving
Adjuvant Therapy Non Small Cell Lung Cancer. Sunil Nagpal MD Director, Thoracic Oncology Jan 30, 2015
Adjuvant Therapy Non Small Cell Lung Cancer Sunil Nagpal MD Director, Thoracic Oncology Jan 30, 2015 No Disclosures Number of studies Studies Per Month 12 10 8 6 4 2 0 1 2 3 4 5 6 7 8 9 10 11 12 1 2 3
Avastin: Glossary of key terms
Avastin: Glossary of key terms Adenocarcinoma Adenoma Adjuvant therapy Angiogenesis Anti-angiogenics Antibody Antigen Avastin (bevacizumab) Benign A form of carcinoma that originates in glandular tissue.
ALCHEMIST (Adjuvant Lung Cancer Enrichment Marker Identification and Sequencing Trials)
ALCHEMIST (Adjuvant Lung Cancer Enrichment Marker Identification and Sequencing Trials) 3 Integrated Trials Testing Targeted Therapy in Early Stage Lung Cancer Part of NCI s Precision Medicine Effort in
Lung Cancer Treatment Guidelines
Updated June 2014 Derived and updated by consensus of members of the Providence Thoracic Oncology Program with the aid of evidence-based National Comprehensive Cancer Network (NCCN) national guidelines,
Re irradiation Using HDR Interstitial Brachytherapy for Locally Recurrent. Disclosure
Re irradiation Using HDR Interstitial Brachytherapy for Locally Recurrent Cervical lcancer Yasuo Yoshioka, MD Department of Radiation Oncology Osaka University Graduate School of Medicine Osaka, Japan
How TARGIT Intra-operative Radiotherapy can help Older Patients with Breast cancer
How TARGIT Intra-operative Radiotherapy can help Older Patients with Breast cancer Jeffrey S Tobias, Jayant S Vaidya, Frederik Wenz and Michael Baum, University College Hospital, London, UK - on behalf
Vascular resection during pancreaticoduodenectomy. Ryan Turley, MD Research Fellow, Duke University
Vascular resection during pancreaticoduodenectomy. Ryan Turley, MD Research Fellow, Duke University Vascular Resection during PD Outline Review of pancreatic adenocarcinoma Role of PD in treatment of pancreatic
Pancreatic Cancer. The Killer that must be discovered early. Dr Alfred Kow Wei Chieh
Pancreatic Cancer The Killer that must be discovered early 27 th June 2015 Dr Alfred Kow Wei Chieh Consultant Department of Surgery Division of HPB Surgery & Liver Transplantation & Assistant Dean (Education)
BASED ON THE RESULTS of the Radiation Therapy
INT 0123 (Radiation Therapy Oncology Group 94-05) Phase III Trial of Combined-Modality Therapy for Esophageal Cancer: High-Dose Versus Standard-Dose Radiation Therapy By Bruce D. Minsky, Thomas F. Pajak,
Malignant Mesothelioma: an Update
Malignant Mesothelioma: an Update Nico van Zandwijk Asbestos Diseases Research Institute Bernie Banton Centre University of Sydney Australia Physicians Week RACP 19-5-2009 Health Risks of Asbestos Fibers
Locoregional & advanced esophagus or esophagogastric junction cancer
Eloxatin (oxaliplatin) Prior Authorization Request (For Maryland Only) Send completed form to: Case Review Unit CVS/caremark Specialty Programs Fax: 866-249-6155 CVS/caremark administers the prescription
Controversies in Management of. Inoperable NSCLC. Inoperable NSCLC. Introduction:
Inoperable NSCLC Controversies in Management of Inoperable NSCLC Introduction: It is difficult to overemphasize the magnitude of lung cancer as Public Health Problem in our society. - In US, Lung cancer
Extrapleural Pneumonectomy for Malignant Mesothelioma: Pro. Joon H. Lee 9/17/2012
Extrapleural Pneumonectomy for Malignant Mesothelioma: Pro Joon H. Lee 9/17/2012 Malignant Pleural Mesothelioma (Epidemiology) Incidence: 7/mil (Japan) to 40/mil (Australia) Attributed secondary to asbestos
GENERAL SUMMARY AND DISCUSSION
GENERAL SUMMARY AND DISCUSSION In the last 30 years, abdominal surgery has progressed from the standard open approach to less invasive techniques such as laparoscopy and natural orifice translumenal endoscopic
Phase 1 Trial of Preoperative, Short-Course Carbon-Ion Radiotherapy for Patients With Resectable Pancreatic Cancer
Phase 1 Trial of Preoperative, Short-Course Carbon-Ion Radiotherapy for Patients With Resectable Pancreatic Cancer Makoto Shinoto, MD 1,2 ; Shigeru Yamada, MD, PhD 1 ; Shigeo Yasuda, MD, PhD 1 ; Hiroshi
Radiation Therapy in the Treatment of
Lung Cancer Radiation Therapy in the Treatment of Lung Cancer JMAJ 46(12): 537 541, 2003 Kazushige HAYAKAWA Professor and Chairman, Department of Radiology, Kitasato University School of Medicine Abstract:
restricted to certain centers and certain patients, preferably in some sort of experimental trial format.
Managing Pancreatic Cancer, Part 4: Pancreatic Cancer Surgery, Complications, & the Importance of Surgical Volume Dr. Matthew Katz, Surgeon, MD Anderson Cancer Center, Houston, TX I m going to talk a little
REPORT ASCO 1998 LOS ANGELES : LUNG CANCER Johan F. Vansteenkiste, MD, PhD, Univ. Hospital and Leuven Lung Cancer Group
REPORT ASCO 1998 LOS ANGELES : LUNG CANCER Johan F. Vansteenkiste, MD, PhD, Univ. Hospital and Leuven Lung Cancer Group Educational session Treatment of stage III non-small cell lung cancer (NSCLC) in
Intervention(s) Results primary outcome Results secondary and other outcomes
Uitgangsvraag 1: evidence tables Systematic reviews Study ID Method Patient Critical appraisal of review quality Fiorica SR and MA 2004 1 Supported by Universities and a cancer centre Search date until
A pilot study of an individualized comprehensive treatment for advanced gastric cancer with para-aortic lymph node metastasis
1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 A pilot study of an individualized comprehensive treatment for advanced gastric cancer with para-aortic lymph node metastasis Qi He 1,
Concurrent Chemotherapy and Radiotherapy for Head and Neck Cancer
Concurrent Chemotherapy and Radiotherapy for Head and Neck Cancer Ryan J. Burri; Nancy Y. Lee Published: 03/23/2009 Abstract and Introduction Abstract Head and neck cancer is best managed in a multidisciplinary
Multimodal Treatment of Resectable Gastric Cancer with Intensive Neoadjuvant Radiation Therapy: Obninsk Radiological Center Experience
The Open Surgical Oncology Journal, 2011, 3, 1-6 1 Open Access Multimodal Treatment of Resectable Gastric Cancer with Intensive Neoadjuvant Radiation Therapy: Obninsk Radiological Center Experience V.
Cancer of the Pancreas
Cancer of the Pancreas James H. North Jr., M.D., F.A.C.S. It is estimated that in 2007, 37,170 patients will be diagnosed with cancer of the pancreas and 33,370 patients will die of this disease. 1 The
Radioterapia panencefalica. Umberto Ricardi
Radioterapia panencefalica Umberto Ricardi Background Systemic disease to the brain is unfortunately a quite common event Radiotherapy, especially with the great technical development during the past decades,
Management of Postmenopausal Women with T1 ER+ Tumors: Options and Tradeoffs. Case Study. Surgery. Lumpectomy and Radiation
Management of Postmenopausal Women with T1 ER+ Tumors: Options and Tradeoffs Michael Alvarado, MD Associate Professor of Surgery University of California San Francisco Case Study 59 yo woman with new palpable
Hepatocellular Carcinoma Treatment Decision Tree
Treatment Decision Tree Derek DuBay, MD Assistant Professor of Surgery Liver Transplant and Hepatobiliary Surgery UAB Department of Surgery 1 UAB Liver Tumor Clinic Referrals: 205 996 5970 (phone) 205
PRINCESS MARGARET CANCER CENTRE CLINICAL PRACTICE GUIDELINES
PRINCESS MARGARET CANCER CENTRE CLINICAL PRACTICE GUIDELINES GASTROINTESTINAL HEPATOCELLULAR CARCINOMA GI Site Group Hepatocellular Carcinoma Authors: Dr. Jennifer Knox, Dr. Mairead McNamara 1. INTRODUCTION
Sleeve gastrectomy or gastric bypass as revisional bariatric procedures: retrospective evaluation of outcomes. Abstract Background Methods:
Sleeve gastrectomy or gastric bypass as revisional bariatric procedures: retrospective evaluation of outcomes. Mousa Khoursheed, Ibtisam Al-Bader, Ali Mouzannar, Abdulla Al-Haddad, Ali Sayed, Ali Mohammad,
Image. 3.11.3 SW Review the anatomy of the EAC and how this plays a role in the spread of tumors.
Neoplasms of the Ear and Lateral Skull Base Image 3.11.1 SW What are the three most common neoplasms of the auricle? 3.11.2 SW What are the four most common neoplasms of the external auditory canal (EAC)
PRIMARY GLIOMA (oligodendroglioma, astrocytoma, oligodendroglioma, oligoastrocytoma, including anaplastic, gliosarcoma and glioblastoma multiforme)
Protocol for Planning and Treatment The process to be followed when a course of chemotherapy is required to treat: PRIMARY GLIOMA (oligodendroglioma, astrocytoma, oligodendroglioma, oligoastrocytoma, including
THE SECRETS OF OUR SUCCESS
THE SECRETS OF OUR SUCCESS QUALITY OF LIFE STUDIES OF THE NCIC Andrea Bezjak, MDCM, MSc,, FRCPC Chair, NCIC CTG QOL Committee Outline of the Presentation Can we consider NCIC CTG QOL activities a success?
Metastatic breast cancer represents an incurable condition associated with an average survival time of 18 to 24 months.
TACT-2C Trial A phase II randomized, open-label study evaluating the addiction of trastuzumabto (nabtm)-paclitaxel as first line treatment in primary HER2 negative metastatic breast cancer patients with
Cancer - Therapeutic Process of Rapid proliferating Tumors
Workshop Interdisciplinare radiazioni: biologia, clinica, ambiente e protezione Centro Ricerche Casaccia ENEA Roma, 14 maggio 2009 basse dosi in radioterapia Alessio G. Morganti 1,2,3, Mariangela Massaccesi
Clinical case Pleural mesothelioma. Francesco Lucio
Clinical case Pleural mesothelioma Francesco Lucio Malignat Pleural Mesothelioma Mesothelioma is a rare malignant tumour originating from the cells lining the mesothelial surface of the coelomic cavities
Moving forward, where are we with Clinical Trials?
Moving forward, where are we with Clinical Trials? Dennis A. Wigle Division of Thoracic Surgery Mayo Clinic AATS/STS General Thoracic Surgery Symposium Sunday, April 27 th 2014 2012 MFMER slide-1 Where
Challenges in gastric, appendiceal and rectal NETs Leuven, 29.11.2014
Challenges in gastric, appendiceal and rectal NETs Leuven, 29.11.2014 Prof. Dr. Chris Verslype, Leuven Prof. Dr. Aurel Perren, Bern Menue Challenges: 1. Gastric NET 2. Appendiceal NET 3. Rectal NET SEER,
Stage IIIB disease includes patients with T4 tumors,
Guidelines on Treatment of Stage IIIB Non-small Cell Lung Cancer* James R. Jett, MD, FCCP; Walter J. Scott, MD, FCCP; M. Patricia Rivera MD, FCCP; and William T. Sause, MD, FACR Stage IIIB includes patients
NEOPLASMS OF KIDNEY (RENAL CELL CARCINOMA) And RENAL PELVIS (TRANSITIONAL CELL CARCINOMA)
NEOPLASMS OF KIDNEY (RENAL CELL CARCINOMA) And RENAL PELVIS (TRANSITIONAL CELL CARCINOMA) Merat Esfahani, MD Medical Oncologist, Hematologist Cancer Liaison Physician SwedishAmerican Regional Cancer Center
7. Prostate cancer in PSA relapse
7. Prostate cancer in PSA relapse A patient with prostate cancer in PSA relapse is one who, having received a primary treatment with intent to cure, has a raised PSA (prostate-specific antigen) level defined
ATLAS FOR THE DELINEATION OF THE POSTOPERATIVE TREATMENT OF PANCREATIC CANCER
CONSENSUS PANEL CONTOURING ATLAS FOR THE DELINEATION OF THE CLINICAL TARGET VOLUME IN THE POSTOPERATIVE TREATMENT OF PANCREATIC CANCER Collaborators Ross A. Abrams, M.D. 1, William F. Regine, M.D. 2, Karyn
Malignant Pleural Mesothelioma in Singapore
RESEARCH COMMUNICATION C SP Yip 1, HN Koong 2, CM Loo 3, KW Fong 1* Abstract Aim: To examine the clinical characteristics and outcomes of malignant pleural mesothelioma (MPM) in Singapore. Methods and
Mediterranean School of Oncology
Mediterranean School of Oncology Organized and supported by: CINBO Consorzio Interuniversitario Nazionale per la Bioncologia HIGHLIGHTS IN THE MANAGEMENT OF COLORECTAL CANCER, February 1-2, 2007 Domus
CANCER PULMON: ESTADIOS INICIALES POSTMUNDIAL PULMON DENVER 2015. 8-10-2015.Manuel Cobo Dols S. Oncología Médica HU Málaga Regional y VV
CANCER PULMON: ESTADIOS INICIALES POSTMUNDIAL PULMON DENVER 2015 8-10-2015.Manuel Cobo Dols S. Oncología Médica HU Málaga Regional y VV Meta-analisis LACE: adyuvancia vs no adyuvancia Pignon JP, et al.
Objectives. Mylene T. Truong, MD. Malignant Pleural Mesothelioma Background
Imaging of Pleural Tumors Mylene T. Truong, MD Imaging of Pleural Tumours Mylene T. Truong, M. D. University of Texas M.D. Anderson Cancer Center, Houston, TX Objectives To review tumors involving the