BOOSTER System: Development of a Toolbox for Triage of a Large Group of Individuals Exposed to Radioactive Material

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Theme 10: Security Call FP7-SEC-2009-1 Project funded by the European Union BOOSTER System: Development of a Toolbox for Triage of a Large Group of Individuals Exposed to Radioactive Material V.

1 Theme 10: Security Call FP7-SEC Project funded by the European Union BOOSTER System: Development of a Toolbox for Triage of a Large Group of Individuals Exposed to Radioactive Material V. SCHOEPFF (1), I. ALAMSI (2), K. AMGAROU (3), F. BECKER (4), F. CARREL (1), F. CARVAJAL (5), D.C. GABORIAU (6), M. GMAR (1), A. KOVACS (3), H. LEMAIRE (1), N. MENAA (3), L. MORAT (7), C.G. MORRISON (6), I. PEREZ LLOPIS (5), W. RASKOB (4), S. SZABO (2), E. SZELES (2), I. TESTARD (7), D. TRYBUSHNYI (4), N. UGOLIN (7), M. VIAU (7), A. VINCZE (8) vincent.schoepff@cea.fr (1) CEA, LIST, Gif-sur-Yvette CEDEX, France; (2) Center for Energy Research, Hungarian Academy of Sciences, Budapest, Hungary; (3) AREVA CANBERRA, France; (4) Karlsruhe Institute of Technology, Germany; (5) Universidad Politécnica de Valencia, Spain; (6) Centre for Chromosome Biology, National University of Ireland Galway, Ireland; (7) CEA, DSV, Fontenay-aux-Roses Cedex, France; (8) Hungarian Atomic Energy Authority, Hungary

PEREZ LLOPIS (5), W. RASKOB (4), S. SZABO (2), E. SZELES (2), I. TESTARD (7), D. TRYBUSHNYI (4), N. UGOLIN (7), M. VIAU (7), A. VINCZE (8) vincent.schoepff@cea.

2 Content o Context and objectives o Architecture of the system o 1 st phase Red Zone response o 2 nd phase Triage of victims o 3 rd phase Support to medical treatment o Forseen impact and conclusion ANIMMA 2013 Conference, June 27 th 2013, Marseille 1

o 3 rd phase Support to medical treatment o Forseen impact and

3 Content o Context and objectives o Architecture of the system o 1 st phase Red Zone response o 2 nd phase Triage of victims o 3 rd phase Support to medical treatment o Forseen impact and conclusion ANIMMA 2013 Conference, June 27 th 2013, Marseille 2

4 Context and Objectives Mitigation of a radiological event Reality and impact of terrorist threats. Recent nuclear accidents. Events involving the exposure of a large number of people Objectives of the BOOSTER Project: Allowing an effective management of the crisis by providing a mechanism for fast situation assessment and fast triage of exposed individuals ANIMMA 2013 Conference, June 27 th 2013, Marseille 3

Events involving the exposure of a large number of people Objectives of the BOOSTER Project: Allowing

Context and Objectives The BOOSTER Consortium 7 partners from 5 countries Radiological instrumentation Decision support Radiological instrumentation Biological dosimetry Radiological forensic Crisis

5 Context and Objectives The BOOSTER Consortium 7 partners from 5 countries Radiological instrumentation Decision support Radiological instrumentation Biological dosimetry Radiological forensic Crisis management Command & Control Biological dosimetry Project started July 2010, ending in October ,5 M partly funded by the European Union under the 7 th Framework Programme, Security Theme ANIMMA 2013 Conference, June 27 th 2013, Marseille 4

Command & Control Biological dosimetry Project started July 2010, ending in October 2013 4,5 M partly funded

6 Context and Objectives Aims Give First Responders the required information for situation assessment; Provide Triage Teams with the necessary dose and toxicity evaluation for categorization of victims; Allow a potential further follow-up material for medical staff at medium/long term post-event; Provide Local and National Crisis Managers with the overall situation awareness for mitigation of the event and recovery; Integrate all components into a single easy-to-use toolbox. ANIMMA 2013 Conference, June 27 th 2013, Marseille 5

at medium/long term post-event; Provide Local and National Crisis Managers with the overall situation awareness for mitigation of

7 Content o Context and objectives o Architecture of the system o 1 st phase Red Zone response o 2 nd phase Triage of victims o 3 rd phase Support to medical treatment o Forseen impact and conclusion ANIMMA 2013 Conference, June 27 th 2013, Marseille 6

8 Architecture of the System Overall System Design The BOOSTER System architecture encompasses different areas around the event location: - Exclusion area - Decontamination area - Support area - Remote command & control (C2) area ANIMMA 2013 Conference, June 27 th 2013, Marseille 7

Exclusion area - Decontamination area - Support area - Remote command

Environmental radiological measurements and forecasts for Situation assessment (PHASE 1) Architecture of the System Overall System Design Radiological and biological measurements

9 Environmental radiological measurements and forecasts for Situation assessment (PHASE 1) Architecture of the System Overall System Design Radiological and biological measurements on samples for Categorization of victims (PHASE 2) Central storage of all gathered data for Crisis managers In-lab biological measurements for Further treatment elements (PHASE 3) 8

on samples for Categorization of victims (PHASE 2) Central storage of all gathered data

10 Content o Context and objectives o Architecture of the system o 1 st phase Red Zone response o 2 nd phase Triage of victims o 3 rd phase Support to medical treatment o Forseen impact and conclusion ANIMMA 2013 Conference, June 27 th 2013, Marseille 9

11 Red Zone response Informing First Responders Gamma camera (Gampix) for hot spot location; Dose-rate-meters (Colibri & GPS-COM) for real time radiological measurements; Portable HPGe (FALCON 5000) for identification of radionuclides. Allow the cartography of the radiological situation and therefore the assessment of the dose received by irradiation. ANIMMA 2013 Conference, June 27 th 2013, Marseille 10

5000) for identification of radionuclides.

12 Red Zone response Focus on GAMPIX Gamma camera: - Allows seeing the exact location of radioactive hot spots by superimposing a gamma image on a visible picture ; - Results possibly obtain in less than 1 second for plutonium up to 5 minutes for higher energies; - Really compact and light (1kg). - Dose rate response tested on a 137 Cs irradiator: Linearity between 150 ngy.h -1 to 23 Gy.h -1. ANIMMA 2013 Conference, June 27 th 2013, Marseille 11

plutonium up to 5 minutes for higher energies; - Really compact and light (1kg).

13 Red Zone response Focus on - Tested over isotopes stated in the American national standard performance requirements for personal radiation detectors for homeland security. Uranyle Acetate Eu Ir Natural Uranium ANIMMA 2013 Conference, June 27 th 2013, Marseille 12

radiation detectors for homeland security.

14 Red Zone response Informing Crisis Managers All devices are connected to the central C2 (SIMACOP) through different communication means. This allows a real time assessment of the situation. C2 is coupled with a decision support system that gives forecasts of the evolution of contaminated area and assists crisis managers in their decision (based on RODOS system). Focus will be made on interoperability with existing National Systems. ANIMMA 2013 Conference, June 27 th 2013, Marseille 13

C2 is coupled with a decision support system that gives forecasts of the evolution of contaminated area and assists crisis

15 Content o Context and objectives o Architecture of the system o 1 st phase Red Zone response o 2 nd phase Triage of victims o 3 rd phase Support to medical treatment o Forseen impact and conclusion ANIMMA 2013 Conference, June 27 th 2013, Marseille 14

16 Triage of Victims Informing Decontamination Staff Bar code wristband for victims ID and followup; Detection portal system (MiniSentry) for contamination monitoring; Decontamination tent equipment with dedicated measurement probes (CANBERRA Smart Probes). Allows the determination of the dose received by external contamination. ANIMMA 2013 Conference, June 27 th 2013, Marseille 15

tent equipment with dedicated measurement probes (CANBERRA Smart Probes).

17 Triage of Victims Informing Triage Staff A complete kit for a first determination of the dose received by internal contamination and irradiation is installed in the Support area: - Low-Background Spectroscopy on biological samples and environment samples; - Portable LIBS analysis of biological samples; - Retrospective dosimetry using environment samples and SMD resistors from cell phones; - Biodosimetry using γh2ax quantification. All results, obtained in less than 20min, are linked with the victim ID and stored in a database for proceded by DSS for triage instructions and medical care. ANIMMA 2013 Conference, June 27 th 2013, Marseille 16

dosimetry using environment samples and SMD resistors from cell phones; - Biodosimetry using γh2ax quantification.

18 Triage of Victims Focus on Brand new sampling methods using very simple tools for body fluids sampling and pilose follicle sampling. Usable by non experts non invasive! ANIMMA 2013 Conference, June 27 th 2013, Marseille 17

19 TL (a. u.) Triage of Victims Focus on Biodosimetry using the detection of DNA damages: based on the measurement of the phosphorylation of H2AX protein following an irradiation. a mgy 720 mgy 360 mgy 180 mgy 90 mgy zero dose Analyses of samples and SMD for retrospective dosimetry: based on the Thermoluminescence properties of SMD resistors and natural materials temperature C ANIMMA 2013 Conference, June 27 th 2013, Marseille 18

phosphorylation of H2AX protein following an irradiation.

20 Content o Context and objectives o Architecture of the system o 1st phase Red Zone response o 2nd phase Triage of victims o 3rd phase Support to medical treatment o Forseen impact and conclusion ANIMMA 2013 Conference, June 27 th 2013, Marseille 19

3rd phase Support to medical treatment o Forseen impact and

21 Support to Medical Treatment Informing Medical Staff & Hospitals Additional analyses off-site (in-lab) for more precision on the medical impact on the victim : - Liquid scintillation analysis of biological samples and environment samples; - ICP-MS analysis of biological samples; - Diffraction methods on biological samples for granulometry; - Biodosimetry using centrosome quantification; - Confirmation of the dose possible via cytogenetics method. Results, stored in the database, along with previous ones, gives additionnal information (especially toxicity information) for possible medical treatments to be given. ANIMMA 2013 Conference, June 27 th 2013, Marseille 20

22 Support to Medical Treatment Focus on Biodosimetry using the quantification of centrosomes in irradiated cells. Decision aiding component, based on the TMT Handbook, mix up all data for giving necessary information for triage and situation mitigation. ANIMMA 2013 Conference, June 27 th 2013, Marseille 21

23 Content o Context and objectives o Architecture of the system o 1 st phase Red Zone response o 2 nd phase Triage of victims o 3 rd phase Support to medical treatment o Forseen impact and conclusion ANIMMA 2013 Conference, June 27 th 2013, Marseille 22

24 Impact and Conclusion Support local rescue personnel in their activities in the first hours; Securing the first responders from exposure; Significantly improve the mitigation capability; Focusing the effort on the affected area only and thereby, reducing cost of the operation. ANIMMA 2013 Conference, June 27 th 2013, Marseille 23

Impact and Conclusion Propose new efficient biodosimetric tools for in-field use; Monitoring of the actual irradiation level of the victim; Measurement of external contamination and internal

25 Impact and Conclusion Propose new efficient biodosimetric tools for in-field use; Monitoring of the actual irradiation level of the victim; Measurement of external contamination and internal contamination (down to fg); Fast triage into 3 categories: - Individuals requiring urgent hospitalization - Individuals requiring close follow up - Not affected individuals ANIMMA 2013 Conference, June 27 th 2013, Marseille 24

26 Thank You for Your Attention Theme 10: Security Call FP7-SEC Contact: Info: Project funded by the European Union

BiO-dOSimetric Tools for triage to Responders. 14 th International Congress of Radiation Research Warsaw, Poland, August 28 - September 1, 2011

BiO-dOSimetric Tools for triage to Responders mehdi.gmar@cea.fr 14 th International Congress of Radiation Research Warsaw, Poland, August 28 - September 1, 2011 Theme 10: Security Call FP7-SEC-2009-1 5